Pediatric Pulmonology, Critical Care, & Allergy

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2020

Acute respiratory failure and the kinetics of neutrophil recovery in pediatric hematopoietic cell transplantation: a multicenter study

Investigators of the Pediatric Acute Lung Injury and Sepsis Network, Feb 1 2020, In : Bone marrow transplantation.

Research output: Contribution to journalArticle

1 Scopus citations

Antenatal corticosteriods decrease forced vital capacity in infants born fullterm

Bandyopadhyay, A., Slaven, J. E., Evrard, C., Tiller, C., Haas, D. M. & Tepper, R. S., Oct 1 2020, In : Pediatric pulmonology. 55, 10, p. 2630-2634 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

APS/SPR Virtual Chat: race, racism, and child health equity in academic pediatrics

Coker, T. R., Keller, D., Davis, S. & Abman, S., 2020, (Accepted/In press) In : Pediatric Research.

Research output: Contribution to journalArticle

Bcl6 and Blimp1 reciprocally regulate ST2+ Treg–cell development in the context of allergic airway inflammation

Koh, B., Ulrich, B. J., Nelson, A. S., Panangipalli, G., Kharwadkar, R., Wu, W., Xie, M. M., Fu, Y., Turner, M. J., Paczesny, S., Janga, S. C., Dent, A. L. & Kaplan, M. H., 2020, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Open Access

Calcitriol regulates the differentiation of IL-9-secreting Th9 cells by modulating the transcription factor PU.1

Vyas, S. P., Hansda, A. K., Kaplan, M. H. & Goswami, R., Mar 1 2020, In : Journal of Immunology. 204, 5, p. 1201-1213 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Changes in the parent cystic fibrosis questionnaire-revised (CFQ-R) with respiratory symptoms in preschool children with cystic fibrosis

Perrem, L., Stanojevic, S., Shaw, M., Davis, S., Retsch-Bogart, G. & Ratjen, F., May 2020, In : Journal of Cystic Fibrosis. 19, 3, p. 492-498 7 p.

Research output: Contribution to journalArticle

Open Access

Comparison of Multiple Breath Washout and Spirometry in Children with Primary Ciliary Dyskinesia and Cystic Fibrosis and Healthy Controls

Kinghorn, B. A., McNamara, S., Genatossio, A., Sullivan, E., Siegel, M., Bauer, I., Clem, C., Johnson, R. C., Davis, M., Griffiths, A., Wheeler, W., Johnson, K., Davis, S. D., Leigh, M. W., Rosenfeld, M. & Pittman, J., Sep 1 2020, In : Annals of the American Thoracic Society. 17, 9, p. 1085-1093 9 p.

Research output: Contribution to journalArticle

Ex vivo culture of mouse skin activates an interleukin 1 alpha-dependent inflammatory response

Zhou, H. M., Slominski, R. M., Seymour, L. J., Bell, M. C., Dave, P., Atumonye, J., Wright, W., Dawes, A., Griesenauer, B., Paczesny, S., Kaplan, M. H., Spandau, D. F. & Turner, M. J., Jan 1 2020, In : Experimental Dermatology. 29, 1, p. 102-106 5 p.

Research output: Contribution to journalArticle

Health care resource utilization for children requiring prolonged mechanical ventilation via tracheostomy

Rogerson, C. M., Beardsley, A. L., Nitu, M. E. & Cristea, A. I., Aug 1 2020, In : Respiratory care. 65, 8, p. 1147-1153 7 p.

Research output: Contribution to journalArticle

Influence of aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1 on epithelial differentiation and organization during lung development

Lee, D. D., Hochstetler, A., Sah, E., Xu, H., Lowe, C. W., Santiaguel, S., Thornton, J. L., Pajakowski, A. & Schwarz, M. A., Aug 2020, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 319, 2, p. L369-L379

Research output: Contribution to journalArticle

1 Scopus citations

Inhibition of stearoyl-CoA desaturases suppresses follicular help T- and germinal center B- cell responses

Son, Y. M., Cheon, I. S., Goplen, N. P., Dent, A. L. & Sun, J., Jul 1 2020, In : European Journal of Immunology. 50, 7, p. 1067-1077 11 p.

Research output: Contribution to journalArticle

Lung biopsy in children's interstitial and diffuse lung disease: Does it alter management?

Hafezi, N., Heimberger, M. A., Lewellen, K. A., Maatman, T., Montgomery, G. S. & Markel, T. A., Apr 1 2020, In : Pediatric pulmonology. 55, 4, p. 1050-1060 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

NMP4 regulates the innate immune response to influenza A virus infection

Yang, S., Adaway, M., Du, J., Huang, S., Sun, J., Bidwell, J. P. & Zhou, B., Jan 1 2020, (Accepted/In press) In : Mucosal Immunology.

Research output: Contribution to journalArticle

Respiratory pathogens associated with intubated pediatric patients following hematopoietic cell transplant

Gertz, S. J., McArthur, J., Hsing, D. D., Nitu, M. E., Smith, L. S., Loomis, A., Fitzgerald, J. C., Duncan, C. N., Mahadeo, K. M., Moffet, J., Hall, M. W., Pinos, E. L., Cheifetz, I. M. & Rowan, C. M., Aug 1 2020, In : Transplant Infectious Disease. 22, 4, e13297.

Research output: Contribution to journalArticle

T follicular regulatory cells and IL-10 promote food antigen-specific IgE

Xie, M. M., Chen, Q., Liu, H., Yang, K., Koh, B., Wu, H., Maleki, S. J., Hurlburt, B. K., Cook-Mills, J., Kaplan, M. H. & Dent, A. L., Jul 1 2020, In : Journal of Clinical Investigation. 130, 7, p. 3820-3832 13 p.

Research output: Contribution to journalArticle

Open Access

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL

Rodriguez, S., Abundis, C., Boccalatte, F., Mehrotra, P., Chiang, M. Y., Yui, M. A., Wang, L., Zhang, H., Zollman, A., Bonfim-Silva, R., Kloetgen, A., Palmer, J., Sandusky, G., Wunderlich, M., Kaplan, M. H., Mulloy, J. C., Marcucci, G., Aifantis, I., Cardoso, A. A. & Carlesso, N., May 1 2020, In : Leukemia. 34, 5, p. 1241-1252 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome

Hsieh, W. Y., Zhou, Q. D., York, A. G., Williams, K. J., Scumpia, P. O., Kronenberger, E. B., Hoi, X. P., Su, B., Chi, X., Bui, V. L., Khialeeva, E., Kaplan, A., Son, Y. M., Divakaruni, A. S., Sun, J., Smale, S. T., Flavell, R. A. & Bensinger, S. J., Jul 7 2020, In : Cell Metabolism. 32, 1, p. 128-143.e5

Research output: Contribution to journalArticle

1 Scopus citations

Toxoplasma gondii co-opts the unfolded protein response to enhance migration and dissemination of infected host cells

Augusto, L., Martynowicz, J., Amin, P. H., Alakhras, N. S., Kaplan, M. H., Wek, R. C. & Sullivan, W. J., Aug 2020, In : mBio. 11, 4, p. 1-13 13 p., e00915-20.

Research output: Contribution to journalArticle

Open Access

Transcriptomic modifications in developmental cardiopulmonary adaptations to chronic hypoxia using a murine model of simulated high-altitude exposure

Krishnan, S., Stearman, R., Zeng, L., Fisher, A., Mickler, E. A., Rodriguez, B. H., Simpson, E. R., Cook, T., Slaven, J. E., Ivan, M., Geraci, M., Lahm, T. & Tepper, R. S., Sep 1 2020, In : American journal of physiology. Lung cellular and molecular physiology. 319, 3, p. L456-L470

Research output: Contribution to journalArticle

Open Access

TSLP and IL-33 reciprocally promote each other's lung protein expression and ILC2 receptor expression to enhance innate type-2 airway inflammation

Toki, S., Goleniewska, K., Zhang, J., Zhou, W., Newcomb, D. C., Zhou, B., Kita, H., Boyd, K. L. & Peebles, R. S., Jul 1 2020, In : Allergy: European Journal of Allergy and Clinical Immunology. 75, 7, p. 1606-1617 12 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Urine gastrin-releasing peptide in the first week correlates with bronchopulmonary dysplasia and post-prematurity respiratory disease

Voynow, J. A., Fisher, K., Sunday, M. E., Cotten, C. M., Hamvas, A., Hendricks-Muñoz, K. D., Poindexter, B. B., Pryhuber, G. S., Ren, C. L., Ryan, R. M., Sharp, J. K., Young, S. P., Zhang, H., Greenberg, R. G., Herring, A. H. & Davis, S. D., Apr 1 2020, In : Pediatric pulmonology. 55, 4, p. 899-908 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

BAtF-interacting proteins dictate specificity in th subset activity

Fu, Y., Koh, B., Kuwahara, M., Ulrich, B. J., Kharwadkar, R., Yamashita, M. & Kaplan, M. H., Oct 1 2019, In : Journal of Immunology. 203, 7, p. 1989-1998 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection

Zhu, B., Zhang, R., Li, C., Jiang, L., Xiang, M., Ye, Z., Kita, H., Melnick, A. M., Dent, A. L. & Sun, J., Jun 11 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 24, p. 11888-11893 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia

Prematurity and Respiratory Outcome Program (PROP) Investigators, Apr 2019, In : Journal of Pediatrics. 207, p. 130-135.e2

Research output: Contribution to journalArticle

9 Scopus citations

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Garg, G., Muschaweckh, A., Moreno, H., Vasanthakumar, A., Floess, S., Lepennetier, G., Oellinger, R., Zhan, Y., Regen, T., Hiltensperger, M., Peter, C., Aly, L., Knier, B., Palam, L. R., Kapur, R., Kaplan, M. H., Waisman, A., Rad, R., Schotta, G., Huehn, J. & 2 others, Kallies, A. & Korn, T., Feb 12 2019, In : Cell Reports. 26, 7, p. 1854-1868.e5

Research output: Contribution to journalArticle

20 Scopus citations

Combination therapy for severe portopulmonary hypertension in a child allows for liver transplantation

Serrano, R. M., Subbarao, G. C., Mangus, R. S., Montgomery, G. & Johansen, M., 2019, In : Pediatric Transplantation. 23, 5, e13461.

Research output: Contribution to journalArticle

1 Scopus citations

Covalent heterobivalent inhibitor design for inhibition of IgE-dependent penicillin allergy in a murine model

Deak, P. E., Kim, B., Koh, B., Qayum, A. A., Kiziltepe, T., Kaplan, M. H. & Bilgicer, B., 2019, In : Journal of Immunology. 203, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry

Wallmeier, J., Frank, D., Shoemark, A., Nöthe-Menchen, T., Cindric, S., Olbrich, H., Loges, N. T., Aprea, I., Dougherty, G. W., Pennekamp, P., Kaiser, T., Mitchison, H. M., Hogg, C., Carr, S. B., Zariwala, M. A., Ferkol, T., Leigh, M. W., Davis, S. D., Atkinson, J., Dutcher, S. K. & 10 others, Knowles, M. R., Thiele, H., Altmüller, J., Krenz, H., Wöste, M., Brentrup, A., Ahrens, F., Vogelberg, C., Morris-Rosendahl, D. J. & Omran, H., Nov 7 2019, In : American Journal of Human Genetics. 105, 5, p. 1030-1039 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen

Deak, P. E., Kim, B., Qayum, A. A., Shin, J., Vitalpur, G., Kloepfer, K. M., Turner, M. J., Smith, N., Shreffler, W. G., Kiziltepe, T., Kaplan, M. H. & Bilgicer, B., Apr 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 18, p. 8966-8974 9 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Differences in the lower airway microbiota of infants with and without cystic fibrosis

Frayman, K. B., Wylie, K. M., Armstrong, D. S., Carzino, R., Davis, S. D., Ferkol, T. W., Grimwood, K., Storch, G. A. & Ranganathan, S. C., Sep 2019, In : Journal of Cystic Fibrosis. 18, 5, p. 646-652 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Dual inhibition of the PI3K and MAPK pathways enhances nab-paclitaxel/gemcitabine chemotherapy response in preclinical models of pancreatic cancer

Awasthi, N., Kronenberger, D., Stefaniak, A., Hassan, M. S., von Holzen, U., Schwarz, M. A. & Schwarz, R. E., Sep 10 2019, In : Cancer Letters. 459, p. 41-49 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Early respiratory viral infections in infants with cystic fibrosis

Deschamp, A. R., Hatch, J. E., Slaven, J. E., Gebregziabher, N., Storch, G., Hall, G. L., Stick, S., Ranganathan, S., Ferkol, T. W. & Davis, S. D., Nov 2019, In : Journal of Cystic Fibrosis. 18, 6, p. 844-850 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Effect of CPAP on airway reactivity and airway inflammation in children with moderate–severe asthma

Praca, E., Jalou, H., Krupp, N., Delecaris, A., Hatch, J., Slaven, J., Gunst, S. J. & Tepper, R. S., Apr 2019, In : Respirology. 24, 4, p. 338-344 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination

Frossi, B., Antoniali, G., Yu, K., Akhtar, N., Kaplan, M. H., Kelley, M. R., Tell, G. & Pucillo, C. E. M., Mar 29 2019, In : Journal of Biological Chemistry. 294, 13, p. 5198-5207 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Expired Tidal Volume Variation in Extremely Low Birth Weight and Very Low Birth Weight Infants on Volume-Targeted Ventilation

Wong, S., Wang, H., Tepper, R., Sokol, G. M. & Rose, R., Jan 1 2019, In : Journal of Pediatrics.

Research output: Contribution to journalArticle

2 Scopus citations
10 Scopus citations

Macrophage PPAR-γ suppresses long-term lung fibrotic sequelae following acute influenza infection

Huang, S., Goplen, N. P., Zhu, B., Cheon, I. S., Son, Y., Wang, Z., Li, C., Dai, Q., Jiang, L., Xiang, M., Carmona, E. M., Vassallo, R., Limper, A. H. & Sun, J., Oct 1 2019, In : PloS one. 14, 10, e0223430.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Novel early life risk factors for adult pulmonary hypertension

Goss, K. N., Austin, E. D., Battiola, T. J., Tepper, R. S. & Lahm, T., Apr 1 2019, In : Pulmonary Circulation. 9, 2

Research output: Contribution to journalArticle

Open Access

Oral Vitamin C (500 mg/d) to pregnant smokers improves infant airway function at 3 months (VCSIP) a randomized trial

McEvoy, C. T., Shorey-Kendrick, L. E., Milner, K., Schilling, D., Tiller, C., Vuylsteke, B., Scherman, A., Jackson, K., Haas, D. M., Harris, J., Schuff, R., Park, B. S., Vu, A., Kraemer, D. F., Mitchell, J., Metz, J., Gonzales, D., Bunten, C., Spindel, E. R., Tepper, R. S. & 1 others, Morris, C. D., May 1 2019, In : American journal of respiratory and critical care medicine. 199, 9, p. 1139-1147 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

PD-1hi CD8+ resident memory T cells balance immunity and fibrotic sequelae

Wang, Z., Wang, S., Goplen, N. P., Li, C., Cheon, I. S., Dai, Q., Huang, S., Shan, J., Ma, C., Ye, Z., Xiang, M., Limper, A. H., Porquera, E. C., Kohlmeier, J. E., Kaplan, M., Zhang, N., Johnson, A. J., Vassallo, R. & Sun, J., Jan 1 2019, In : Science Immunology. 4, 36, eaaw1217.

Research output: Contribution to journalArticle

7 Scopus citations

PPAR-γ in macrophages limits pulmonary inflammation and promotes host recovery following respiratory viral infection

Huang, S., Zhu, B., Cheon, I. S., Goplen, N. P., Jiang, L., Zhang, R., Stokes Peebles, R., Mack, M., Kaplan, M. H., Limper, A. H. & Sun, J., May 1 2019, In : Journal of virology. 93, 9, e00030-19.

Research output: Contribution to journalArticle

10 Scopus citations

Primary ciliary dyskinesia: Longitudinal study of lung disease by ultrastructure defect and genotype

and the Genetic Disorders of Mucociliary Clearance Consortium, Jan 15 2019, In : American journal of respiratory and critical care medicine. 199, 2, p. 190-198 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

PU.1 controls fibroblast polarization and tissue fibrosis

Wohlfahrt, T., Rauber, S., Uebe, S., Luber, M., Soare, A., Ekici, A., Weber, S., Matei, A. E., Chen, C. W., Maier, C., Karouzakis, E., Kiener, H. P., Pachera, E., Dees, C., Beyer, C., Daniel, C., Gelse, K., Kremer, A. E., Naschberger, E., Stürzl, M. & 14 others, Butter, F., Sticherling, M., Finotto, S., Kreuter, A., Kaplan, M. H., Jüngel, A., Gay, S., Nutt, S. L., Boykin, D. W., Poon, G. M. K., Distler, O., Schett, G., Distler, J. H. W. & Ramming, A., Feb 21 2019, In : Nature. 566, 7744, p. 344-349 6 p.

Research output: Contribution to journalArticle

26 Scopus citations
5 Scopus citations

Targeting Peroxisome Proliferator-Activated Receptor-Gamma Decreases Host Mortality After Influenza Infection in Obese Mice

Huang, S., Jiang, L., Cheon, I. S. & Sun, J., May 2019, In : Viral Immunology. 32, 4, p. 161-169 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

The Il9 CNS-25 regulatory element controls mast cell and basophil IL-9 production

Qayum, A. A., Koh, B., Martin, R. K., Kenworthy, B. T., Kharwadkar, R., Fu, Y., Wu, W., Conrad, D. H. & Kaplan, M. H., Sep 1 2019, In : Journal of Immunology. 203, 5, p. 1111-1121 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Therapeutic efficacy of anti-MMP9 antibody in combination with nab-paclitaxel-based chemotherapy in pre-clinical models of pancreatic cancer

Awasthi, N., Mikels-Vigdal, A. J., Stefanutti, E., Schwarz, M. A., Monahan, S., Smith, V. & Schwarz, R. E., Jun 2019, In : Journal of Cellular and Molecular Medicine. 23, 6, p. 3878-3887 10 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., Ye, Z., Beckermann, K. E., Wu, Y., Jenkins, J. W., Siska, P. J., Vincent, B. G., Prakash, Y. S., Peikert, T., Edelson, B. T., Taneja, R., Kaplan, M. H., Rathmell, J. C., Dong, H., Hitosugi, T. & 1 others, Sun, J., Sep 17 2019, In : Immunity. 51, 3, p. 491-507.e7

Research output: Contribution to journalArticle

12 Scopus citations

The use of computer decision support for pediatric obstructive sleep apnea detection in primary care

Honaker, S. M., Street, A., Daftary, A. S. & Downs, S. M., 2019, In : Journal of Clinical Sleep Medicine. 15, 3, p. 453-462 10 p.

Research output: Contribution to journalArticle

2018

Absorption and safety with sustained use of RELiZORB evaluation (ASSURE) study in patients with cystic fibrosis receiving enteral feeding

Stevens, J., Wyatt, C., Brown, P., Patel, D., Grujic, D. & Freedman, S. D., Oct 2018, In : Journal of pediatric gastroenterology and nutrition. 67, 4, p. 527-532 6 p.

Research output: Contribution to journalArticle

10 Scopus citations