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2013

Genome-wide discovery of genetic variants affecting tamoxifen sensitivity and their clinical and functional validation

Weng, L., Ziliak, D., Im, H. K., Gamazon, E. R., Philips, S., Nguyen, A. T., Desta, Z., Skaar, T. C., Flockhart, D. A. & Huang, R. S., Jul 1 2013, In : Annals of Oncology. 24, 7, p. 1867-1873 7 p., mdt125.

Research output: Contribution to journalArticle

6 Scopus citations

Gingival evaluation of the pediatric cardiac patient

Nosrati, E., Eckert, G. J., Kowolik, M. J., Ho, J. G., Schamberger, M. S. & Kowolik, J. E., Sep 2013, In : Pediatric dentistry. 35, 5, p. 456-462 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibition of cytochrome P450 enzymes by the E-and Z-isomers of norendoxifen

Liu, J., Flockhart, P. J., Lu, D., Lv, W., Lu, W. J., Han, X., Cushman, M. & Flockhart, D. A., Sep 2013, In : Drug Metabolism and Disposition. 41, 9, p. 1715-1720 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin

Kreutz, R. P., Nystrom, P., Kreutz, Y., Miao, J., Kovacs, R., Desta, Z., Flockhart, D. A. & Jin, Y., Feb 11 2013, In : Platelets. 24, 2, p. 145-150 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Is (+)-[13C]-pantoprazole better than (±)-[ 13C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity?

Thacker, D. L., Modak, A., Flockhart, D. A. & Desta, Z., Mar 2013, In : Journal of Breath Research. 7, 1, 016001.

Research output: Contribution to journalArticle

7 Scopus citations

Knowledge and attitude of dental trauma among mothers in Iraq

Yassen, G. H., Chin, J. R., Younus, M. S. & Eckert, G. J., Aug 1 2013, In : European Archives of Paediatric Dentistry. 14, 4, p. 259-265 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: Genome-wide associations and functional genomics

Ji, Y., Biernacka, J. M., Hebbring, S., Chai, Y., Jenkins, G. D., Batzler, A., Snyder, K. A., Drews, M. S., Desta, Z., Flockhart, D., Mushiroda, T., Kubo, M., Nakamura, Y., Kamatani, N., Schaid, D., Weinshilboum, R. M. & Mrazek, D. A., Oct 1 2013, In : Pharmacogenomics Journal. 13, 5, p. 456-463 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

PharmGKB summary: Tamoxifen pathway, pharmacokinetics

Klein, D. J., Thorn, C. F., Desta, Z., Flockhart, D. A., Altman, R. B. & Klein, T. E., Nov 2013, In : Pharmacogenetics and Genomics. 23, 11, p. 643-647 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Regulation of microRNA expression by rifampin in human hepatocytes

Ramamoorthy, A., Liu, Y., Philips, S., Desta, Z., Lin, H., Goswami, C., Gaedigk, A., Li, L., Flockhart, D. A. & Skaar, T. C., Oct 1 2013, In : Drug Metabolism and Disposition. 41, 10, p. 1763-1768 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Results of an International Randomized Phase III Trial of the Mammalian Target of Rapamycin Inhibitor Ridaforolimus Versus Placebo to Control Metastatic Sarcomas in Patients after Benefit from Prior Chemotherapy

Demetri, G. D., Chawla, S. P., Ray-Coquard, I., Le Cesne, A., Staddon, A. P., Milhem, M. M., Penel, N., Riedel, R. F., Bui-Nguyen, B., Cranmer, L. D., Reichardt, P., Bompas, E., Alcindor, T., Rushing, D., Song, Y., Lee, R. M., Ebbinghaus, S., Eid, J. E., Loewy, J. W., Haluska, F. G. & 2 others, Dodion, P. F. & Blay, J. Y., Jul 1 2013, In : Journal of Clinical Oncology. 31, 19, p. 2485-2492 8 p.

Research output: Contribution to journalArticle

145 Scopus citations

Riga-Fede Disease: A Case Report

Dunlop, R., Barton, D. & Jones, J., Mar 1 2013, In : Journal of Pediatric Health Care. 27, 2, p. 155-157 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression: Individualized breast cancer prevention

Ingle, J. N., Liu, M., Lawrence Wickerham, D., Schaid, D. J., Wang, L., Mushiroda, T., Kubo, M., Costantino, J. P., Vogel, V. G., Paik, S., Goetz, M. P., Ames, M. M., Jenkins, G. D., Batzler, A., Carlson, E. E., Flockhart, D. A., Wolmark, N., Nakamura, Y. & Weinshilboum, R. M., Jul 2013, In : Cancer Discovery. 3, 7, p. 812-825 14 p.

Research output: Contribution to journalArticle

37 Scopus citations

Synthesis of mixed (E, Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities

Lv, W., Liu, J., Lu, D., Flockhart, D. A. & Cushman, M., Jun 13 2013, In : Journal of Medicinal Chemistry. 56, 11, p. 4611-4618 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Traumatic injuries of permanent teeth among 6- to 12-year-old iraqi children: A 4-year retrospective study

Yassen, G. H., Chin, J. R., Al-Rawi, B. A. O., Mohammedsharif, A. G., Alsoufy, S. S., Hassan, L. A. R., Salim, L. H. & Eckert, G., Jan 1 2013, In : Journal of Dentistry for Children. 80, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2012

A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese

Kiyotani, K., Mushiroda, T., Tsunoda, T., Morizono, T., Hosono, N., Kubo, M., Tanigawara, Y., Imamura, C. K., Flockhart, D. A., Aki, F., Hirata, K., Takatsuka, Y., Okazaki, M., Ohsumi, S., Yamakawa, T., Sasa, M., Nakamura, Y. & Zembutsu, H., Apr 1 2012, In : Human molecular genetics. 21, 7, p. 1665-1672 8 p., ddr597.

Research output: Contribution to journalArticle

43 Scopus citations

Comparison of breast cancer recurrence risk and cardiovascular disease incidence risk among postmenopausal women with breast cancer

Bardia, A., Arieas, E. T., Zhang, Z., Defilippis, A., Tarpinian, K., Jeter, S., Nguyen, A., Henry, N. L., Flockhart, D. A., Hayes, D. F., Hayden, J., Storniolo, A. M., Armstrong, D. K., Davidson, N. E., Fetting, J., Ouyang, P., Wolff, A. C., Blumenthal, R. S., Ashen, M. D. & Stearns, V., Feb 1 2012, In : Breast Cancer Research and Treatment. 131, 3, p. 907-914 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Enhanced sensitivity to drug-induced QT interval lengthening in patients with heart failure due to left ventricular systolic dysfunction

Tisdale, J. E., Overholser, B. R., Wroblewski, H. A., Sowinski, K. M., Amankwa, K., Borzak, S., Kingery, J. R., Coram, R., Zipes, D. P., Flockhart, D. A. & Kovacs, R. J., Sep 2012, In : Journal of clinical pharmacology. 52, 9, p. 1296-1305 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Functional Characterization of a Genetic Polymorphism in the Promoter of the ESR2 Gene

Philips, S., Richter, A., Oesterreich, S., Rae, J. M., Flockhart, D. A., Perumal, N. B. & Skaar, T. C., Apr 1 2012, In : Hormones and Cancer. 3, 1-2, p. 37-43 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Impact of the interaction between 3′-UTR SNPs and microRNA on the expression of human xenobiotic metabolism enzyme and transporter genes

Wei, R., Yang, F., Urban, T. J., Li, L., Chalasani, N., Flockhart, D. A. & Liu, W., 2012, In : Frontiers in Genetics. 3, NOV, Article 248.

Research output: Contribution to journalArticle

26 Scopus citations

Induction of CYP2C19 and CYP3A activity following repeated administration of efavirenz in healthy volunteers

Michaud, V., Ogburn, E., Thong, N., Aregbe, A. O., Quigg, T. C., Flockhart, D. A. & Desta, Z., Mar 2012, In : Clinical Pharmacology and Therapeutics. 91, 3, p. 475-482 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response

Kreutz, R. P., Nystrom, P., Kreutz, Y., Miao, J., Desta, Z., Breall, J. A., Li, L., Chiang, C. W., Kovacs, R., Flockhart, D. A. & Jin, Y., 2012, In : Clinical Pharmacology: Advances and Applications. 4, 1, p. 13-20 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Literature Based Drug Interaction Prediction with Clinical Assessment Using Electronic Medical Records: Novel Myopathy Associated Drug Interactions

Duke, J. D., Han, X., Wang, Z., Subhadarshini, A., Karnik, S. D., Li, X., Hall, S. D., Jin, Y., Callaghan, J. T., Overhage, M. J., Flockhart, D. A., Strother, R. M., Quinney, S. K. & Li, L., Aug 2012, In : PLoS computational biology. 8, 8, e1002614.

Research output: Contribution to journalArticle

69 Scopus citations

Pharmacogenetics and healthcare outcomes in patients with chronic heart failure

Kim, K. M., Murray, M. D., Tu, W., Robarge, J., Ding, Y., Brater, D. C. & Flockhart, D. A., Nov 1 2012, In : European Journal of Clinical Pharmacology. 68, 11, p. 1483-1491 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Predictors of aromatase inhibitor discontinuation as a result of treatment-emergent symptoms in early-stage breast cancer

Henry, N. L., Azzouz, F., Desta, Z., Li, L., Nguyen, A. T., Lemler, S., Hayden, J., Tarpinian, K., Yakim, E., Flockhart, D. A., Stearns, V., Hayes, D. F. & Storniolo, A. M., Mar 20 2012, In : Journal of Clinical Oncology. 30, 9, p. 936-942 7 p.

Research output: Contribution to journalArticle

196 Scopus citations

Protease activated receptor-1 (PAR-1) mediated platelet aggregation is dependant on clopidogrel response

Kreutz, R. P., Breall, J. A., Kreutz, Y., Owens, J., Lu, D., Bolad, I., Von Der Lohe, E., Sinha, A. & Flockhart, D. A., Aug 2012, In : Thrombosis Research. 130, 2, p. 198-202 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Reduced methadone clearance during aromatase inhibition

Lu, W. J., Thong, N. & Flockhart, D. A., Aug 1 2012, In : Journal of Clinical Psychopharmacology. 32, 4, p. 511-517 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Tamoxifen metabolites as active inhibitors of aromatase in the treatment of breast cancer

Lu, W. J., Desta, Z. & Flockhart, D. A., Jan 1 2012, In : Breast Cancer Research and Treatment. 131, 2, p. 473-481 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

The effect of frequency of calcium hydroxide dressing change and various pre- and inter-operative factors on the endodontic treatment of traumatized immature permanent incisors

Yassen, G. H., Chin, J., Mohammedsharif, A. G., Alsoufy, S. S., Othman, S. S. & Eckert, G., Aug 1 2012, In : Dental Traumatology. 28, 4, p. 296-301 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents

Lu, W. J., Xu, C., Pei, Z., Mayhoub, A. S., Cushman, M. & Flockhart, D. A., May 1 2012, In : Breast Cancer Research and Treatment. 133, 1, p. 99-109 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Whole genome amplification of DNA for genotyping pharmacogenetics candidate genes

Philips, S., Rae, J. M., Oesterreich, S., Hayes, D. F., Stearns, V., Henry, N. L., Storniolo, A. M., Flockhart, D. A. & Skaar, T. C., Sep 13 2012, In : Frontiers in Pharmacology. 3 MAR, 54.

Research output: Contribution to journalArticle

1 Scopus citations
2011

A modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer

Shen, C., Huang, Y., Liu, Y., Wang, G., Zhao, Y., Wang, Z., Teng, M., Wang, Y., Flockhart, D. A., Skaar, T. C., Yan, P., Nephew, K. P., Huang, T. H. M. & Li, L., May 9 2011, In : BMC Systems Biology. 5, 67.

Research output: Contribution to journalArticle

24 Scopus citations

A phase i study of the safety and pharmacokinetics of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma

Ganjoo, K. N., Cranmer, L. D., Butrynski, J. E., Rushing, D., Adkins, D., Okuno, S. H., Lorente, G., Kroll, S., Langmuir, V. K. & Chawla, S. P., Jun 1 2011, In : ONCOLOGY. 80, 1-2, p. 50-56 7 p.

Research output: Contribution to journalArticle

52 Scopus citations

Caries prevalence and its association with brushing habits, water availability, and the intake of sugared beverages

Guido, J. A., Martinez Mier, E. A., Soto, A., Eggertsson, H., Sanders, B. J., Jones, J. E., Weddell, J. A., Villanueva Cruz, I. & Anton de la Concha, J. L., Nov 1 2011, In : International Journal of Paediatric Dentistry. 21, 6, p. 432-440 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Enantiomers of naringenin as pleiotropic, stereoselective inhibitors of cytochrome P450 isoforms

Lu, W. J., Ferlito, V., Xu, C., Flockhart, D. A. & Caccamese, S., Nov 1 2011, In : Chirality. 23, 10, p. 891-896 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: Results from the NSABP P1 and P2 clinical trials

Goetz, M. P., Schaid, D. J., Wickerham, D. L., Safgren, S., Mushiroda, T., Kubo, M., Batzler, A., Costantino, J. P., Vogel, V. G., Paik, S., Carlson, E. E., Flockhart, D. A., Wolmark, N., Nakamura, Y., Weinshilboum, R. M., Ingle, J. N. & Ames, M. M., Nov 1 2011, In : Clinical Cancer Research. 17, 21, p. 6944-6951 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Fluoride content of water used to reconstitute infant formula

Steinmetz, J. E. A., Martinez-Mier, E. A., Jones, J. E., Sanders, B. J., Weddell, J. A., Soto-Rojas, A. E., Tomlin, A. M. & Eckert, G. J., Feb 1 2011, In : Clinical Pediatrics. 50, 2, p. 100-105 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Fracture resistance of 3 types of primary esthetic stainless steel crowns

Beattie, S., Taskonak, B., Jones, J., Chin, J., Sanders, B., Tomlin, A. & Weddell, J., 2011, In : Journal of the Canadian Dental Association. 77, b90.

Research output: Contribution to journalArticle

14 Scopus citations

Genotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: A multicenter study

Irvin, W. J., Walko, C. M., Weck, K. E., Ibrahim, J. G., Chiu, W. K., Dees, E. C., Moore, S. G., Olajide, O. A., Graham, M. L., Canale, S. T., Raab, R. E., Corso, S. W., Peppercorn, J. M., Anderson, S. M., Friedman, K. J., Ogburn, E. T., Desta, Z., Flockhart, D. A., McLeod, H. L., Evans, J. P. & 1 others, Carey, L. A., Aug 20 2011, In : Journal of Clinical Oncology. 29, 24, p. 3232-3239 8 p.

Research output: Contribution to journalArticle

147 Scopus citations

Identification of caries risk factors in toddlers

Fontana, M., Jackson, R., Eckert, G., Swigonski, N., Chin, J., Ferreira Zandona, A., Ando, M., Stookey, G. K., Downs, S. & Zero, D. T., Feb 1 2011, In : Journal of dental research. 90, 2, p. 209-214 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

In vitro cytochrome P450-mediated metabolism of exemestane

Kamdem, L. K., Flockhart, D. A. & Desta, Z., Jan 1 2011, In : Drug Metabolism and Disposition. 39, 1, p. 98-105 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Methadone adverse reaction presenting with large increase in plasma methadone binding: A case series

Lu, W. J., Zhou, W., Kreutz, Y. & Flockhart, D. A., Oct 11 2011, In : Journal of Medical Case Reports. 5, 513.

Research output: Contribution to journalArticle

3 Scopus citations

Modeling hot flushes and quality of life in breast cancer survivors

Rand, K. L., Otte, J. L., Flockhart, D., Hayes, D., Storniolo, A. M., Stearns, V., Henry, N. L., Nguyen, A., Lemler, S., Hayden, J., Jeter, S. & Carpenter, J. S., Feb 2011, In : Climacteric. 14, 1, p. 171-180 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Morbid obesity and metabolic syndrome in Ossabaw miniature swine are associated with increased platelet reactivity

Kreutz, R. P., Alloosh, M., Mansour, K., Neeb, Z., Kreutz, Y., Flockhart, D. A. & Sturek, M., Jan 1 2011, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 4, p. 99-105 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age

Desta, Z., Kreutz, Y., Nguyen, A. T., Li, L., Skaar, T., Kamdem, L. K., Henry, N. L., Hayes, D. F., Storniolo, A. M., Stearns, V., Hoffmann, E., Tyndale, R. F. & Flockhart, D. A., Nov 2011, In : Clinical Pharmacology and Therapeutics. 90, 5, p. 693-700 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Stereoselective pharmacokinetics of stable isotope (+/-)-[ 13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity

Thacker, D. L., Modak, A., Nguyen, P. D., Flockhart, D. A. & Desta, Z., Nov 2011, In : Chirality. 23, 10, p. 904-909 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Tamoxifen and its metabolites cause acute vasorelaxation of aortic rings by inducing vasodilator prostanoid synthesis

Montenegro, M. F., Ceron, C. S., Salgado, M. C. O., Desta, Z., Flockhart, D. A. & Tanus-Santos, J. E., Dec 1 2011, In : Journal of cardiovascular pharmacology. 58, 6, p. 647-653 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Tamoxifen downregulates Ets oncogene family members ETV4 and ETV5 in benign breast tissue: Implications for durable risk reduction

Euhus, D., Bu, D., Xie, X. J., Sarode, V., Ashfaq, R., Hunt, K., Xia, W., O'Shaughnessy, J., Grant, M., Arun, B., Dooley, W., Miller, A., Flockhart, D. & Lewis, C., Nov 1 2011, In : Cancer Prevention Research. 4, 11, p. 1852-1862 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2010

A penalized mixture model approach in genotype/phenotype association analysis for quantitative phenotypes

Li, L., Borges, S., Jason, R. D., Shen, C., Desta, Z. & Flockhart, D., Jun 4 2010, In : Cancer Informatics. 9, p. 93-103 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients.

Borges, S., Desta, Z., Jin, Y., Faouzi, A., Robarge, J. D., Philips, S., Nguyen, A., Stearns, V., Hayes, D., Rae, J. M., Skaar, T. C., Flockhart, D. A. & Li, L., Apr 2010, In : Journal of clinical pharmacology. 50, 4, p. 450-458 9 p.

Research output: Contribution to journalArticle

87 Scopus citations

Differential quantification of CYP2D6 gene copy number by four different quantitative real-time PCR assays

Ramamoorthy, A., Flockhart, D. A., Hosono, N., Kubo, M., Nakamura, Y. & Skaar, T. C., Jul 2010, In : Pharmacogenetics and Genomics. 20, 7, p. 451-454 4 p.

Research output: Contribution to journalArticle

25 Scopus citations