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2010

Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: Revised and updated results

Hayes, D. F., Skaar, T. C., Rae, J. M., Henry, N. L., Nguyen, A. T., Stearns, V., Li, L., Philips, S., Desta, Z. & Flockhart, D. A., Nov 2010, In : Clinical Pharmacology and Therapeutics. 88, 5, p. 626-629 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors

Ingle, J. N., Schaid, D. J., Goss, P. E., Liu, M., Mushiroda, T., Chapman, J. A. W., Kubo, M., Jenkins, G. D., Batzler, A., Shepherd, L., Pater, J., Wang, L., Ellis, M. J., Stearns, V., Rohrer, D. C., Goetz, M. P., Pritchard, K. I., Flockhart, D. A., Nakamura, Y. & Weinshilboum, R. M., Nov 1 2010, In : Journal of Clinical Oncology. 28, 31, p. 4674-4682 9 p.

Research output: Contribution to journalArticle

152 Scopus citations

Impact of proton pump inhibitors on the effectiveness of clopidogrel after coronary stent placement: The clopidogrel Medco outcomes study

Kreutz, R. P., Stanek, E. J., Aubert, R., Yao, J., Breall, J. A., Desta, Z., Skaar, T. C., Teagarden, J. R., Frueh, F. W., Epstein, R. S. & Flockhart, D. A., Aug 1 2010, In : Pharmacotherapy. 30, 8, p. 787-796 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

Inflammatory cytokines and aromatase inhibitor-associated musculoskeletal syndrome: A case-control study

Henry, N. L., Pchejetski, D., A'Hern, R., Nguyen, A. T., Charles, P., Waxman, J., Li, L., Storniolo, A. M., Hayes, D. F., Flockhart, D. A., Stearns, V. & Stebbing, J., Jul 27 2010, In : British Journal of Cancer. 103, 3, p. 291-296 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole

Kamdem, L. K., Liu, Y., Stearns, V., Kadlubar, S. A., Ramirez, J., Jeter, S., Shahverdi, K., Ward, B. A., Ogburn, E., Ratain, M. J., Flockhart, D. A. & Desta, Z., Dec 2010, In : British Journal of Clinical Pharmacology. 70, 6, p. 854-869 16 p.

Research output: Contribution to journalArticle

56 Scopus citations

Lack of association between oestrogen receptor polymorphisms and change in bone mineral density with tamoxifen therapy

Henry, N. L., Nguyen, A., Azzouz, F., Li, L., Robarge, J., Philips, S., Cao, D., Skaar, T. C., Rae, J. M., Storniolo, A. M., Flockhart, D. A., Hayes, D. F. & Stearns, V., Jan 1 2010, In : British Journal of Cancer. 102, 2, p. 294-300 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Methadone: A substrate and mechanism-based inhibitor of CYP19 (aromatase)

Lu, W. J., Bies, R., Kamden, L. K., Desta, Z. & Flockhart, D. A., Aug 1 2010, In : Drug Metabolism and Disposition. 38, 8, p. 1308-1313 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Pediatricians role in childrens oral health: An Indiana survey

Ditto, M. R., Jones, J. E., Sanders, B., Weddell, J. A., Jackson, R. & Tomlin, A., Jan 1 2010, In : Clinical Pediatrics. 49, 1, p. 12-19 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients

Kiyotani, K., Mushiroda, T., Imamura, C. K., Hosono, N., Tsunoda, T., Kubo, M., Tanigawara, Y., Flockhart, D. A., Desta, Z., Skaar, T. C., Aki, F., Hirata, K., Takatsuka, Y., Okazaki, M., Ohsumi, S., Yamakawa, T., Sasa, M., Nakamura, Y. & Zembutsu, H., Mar 10 2010, In : Journal of Clinical Oncology. 28, 8, p. 1287-1293 7 p.

Research output: Contribution to journalArticle

179 Scopus citations

Variation in anastrozole metabolism and pharmacodynamics in women with early breast cancer

Ingle, J. N., Buzdar, A. U., Schaid, D. J., Goetz, M. P., Batzler, A., Robson, M. E., Northfelt, D. W., Olson, J. E., Perez, E. A., Desta, Z., Weintraub, R. A., Williard, C. V., Flockhart, D. A. & Weinshilboum, R. M., Apr 15 2010, In : Cancer Research. 70, 8, p. 3278-3286 9 p.

Research output: Contribution to journalArticle

58 Scopus citations
2009

Assessment of vascular effects of tamoxifen and its metabolites on the rat perfused hindquarter vascular bed

Montenegro, M. F., Pessa, L. R., Gomes, V. A., Desta, Z., Flockhart, D. A. & Tanus-Santos, J. E., May 1 2009, In : Basic and Clinical Pharmacology and Toxicology. 104, 5, p. 400-407 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort

Lynn Henry, N., Rae, J. M., Li, L., Azzouz, F., Skaar, T. C., Desta, Z., Sikora, M. J., Philips, S., Nguyen, A. T., Storniolo, A. M., Hayes, D. F., Flockhart, D. A. & Stearns, V., Jan 21 2009, In : Breast Cancer Research and Treatment. 117, 3, p. 571-575 5 p.

Research output: Contribution to journalArticle

59 Scopus citations

Comparison of subjective and objective hot flash measures over time among breast cancer survivors initiating aromatase inhibitor therapy

Otte, J. L., Flockhart, D., Hayes, D., Storniolo, A. M., Stearns, V., Schneider, B., Henry, N. L., Azzouz, F., Nguyen, A., Lemler, S., Hayden, J., Jeter, S., Wright, L. & Carpenter, J. S., Jul 2009, In : Menopause. 16, 4, p. 653-659 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Contamination of handpieces during pulpotomy therapy on primary teeth

Chin, J. R., Westerman, A. E., Palenik, C. J. & Eckert, S. G. J., Aug 31 2009, In : Pediatric dentistry. 31, 1, p. 71-75 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast cancer patients

Rae, J. M., Sikora, M. J., Henry, N. L., Li, L., Kim, S., Oesterreich, S., Skaar, T. C., Nguyen, A. T., Desta, Z., Storniolo, A. M., Flockhart, D. A., Hayes, D. F. & Stearns, V., 2009, In : Pharmacogenomics Journal. 9, 4, p. 258-264 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Effect on behavior of dental treatment rendered under conscious sedation and general anesthesia in pediatric patients

Fuhrer, C. T., Weddell, J. A., Sanders, B. J., Jones, J. E., Dean, J. A. & Tomlin, A., Nov 1 2009, In : Pediatric dentistry. 31, 7, p. 492-497 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Estrogen receptor genotype is associated with risk of venous thromboembolism during tamoxifen therapy

Onitilo, A. A., McCarty, C. A., Wilke, R. A., Glurich, I., Engel, J. M., Flockhart, D. A., Nguyen, A., Li, L., Mi, D., Skaar, T. C. & Jin, Y., Jun 1 2009, In : Breast Cancer Research and Treatment. 115, 3, p. 643-650 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes

Schneider, B. P., Radovich, M., Flockhart, D. A., Carpenter, J. S., Li, L., Robarge, J. D., Storniolo, A. M., Hancock, B. A., Skaar, T. C. & Sledge, G. W., Aug 2009, In : Breast Cancer Research and Treatment. 116, 3, p. 543-549 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity

Arefayene, M., Philips, S., Cao, D., Mamidipalli, S., Desta, Z., Flockhart, D. A., Wilkes, D. S. & Skaar, T. C., Jun 1 2009, In : Pharmacogenetics and Genomics. 19, 6, p. 464-476 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
30 Scopus citations

Pharmacogenetics of tamoxifen: Who should undergo CYP2D6 genetic testing?

Higgins, M. J., Rae, J. M., Flockhart, D. A., Hayes, D. F. & Stearns, V., Feb 2009, In : JNCCN Journal of the National Comprehensive Cancer Network. 7, 2, p. 203-213 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

Pharmacotherapy and pregnancy: Highlights from the second international conference for individualized pharmacotherapy in pregnancy

Haas, D. M., Hebert, M. F., Soldin, O. P., Flockhart, D. A., Madadi, P., Nocon, J. J., Chambers, C. D., Hankins, G. D., Clark, S., Wisner, K. L., Li, L., Renbarger, J. L. & Learman, L. A., Dec 1 2009, In : Clinical and translational science. 2, 6, p. 439-443 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Pharmacotherapy and pregnancy: Highlights from the first International Conference for Individualized Pharmacotherapy in Pregnancy.

Haas, D. M., Renbarger, J. L., Denne, S., Ahmed, M. S., Easterling, T., Feibus, K., Meslin, E. M., Koren, G., Zajicek, A., Snodgrass, W. R. & Flockhart, D. A., Feb 2009, In : Clinical and translational science. 2, 1, p. 11-14 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [ 13C]pantoprazole breath test

Desta, Z., Modak, A., Nguyen, P. D., Lemler, S. M., Kurogi, Y., Li, L. & Flockhart, D. A., Apr 2009, In : Journal of Pharmacology and Experimental Therapeutics. 329, 1, p. 297-305 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Xylitol: Effects on the acquisition of cariogenic species in infants

Fontana, M., Catt, D., Eckert, G. J., Ofner, S., Toro, M., Gregory, R. L., Zandona, A. F., Eggertsson, H., Jackson, R., Chin, J., Zero, D. & Sissons, C. H., Aug 27 2009, In : Pediatric dentistry. 31, 3, p. 257-266 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2008

A mixture model approach in gene-gene and gene-environmental interactions for binary phenotypes

Li, L., Yu, M., Jason, R. D., Shen, C., Azzouz, F., McLeod, H. L., Borges-Gonzales, S., Nguyen, A., Skaar, T., Desta, Z., Sweeney, C. J. & Flockhart, D. A., Nov 2008, In : Journal of biopharmaceutical statistics. 18, 6, p. 1150-1177 28 p.

Research output: Contribution to journalArticle

3 Scopus citations

Association of polymorphisms of angiogenesis genes with breast cancer

Schneider, B. P., Radovich, M., Sledge, G. W., Robarge, J. D., Li, L., Storniolo, A. M., Lemler, S., Nguyen, A. T., Hancock, B. A., Stout, M., Skaar, T. & Flockhart, D. A., Sep 2008, In : Breast Cancer Research and Treatment. 111, 1, p. 157-163 7 p.

Research output: Contribution to journalArticle

84 Scopus citations

Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100

Schneider, B. P., Wang, M., Radovich, M., Sledge, G. W., Badve, S., Thor, A., Flockhart, D. A., Hancock, B., Davidson, N., Gralow, J., Dickler, M., Perez, E. A., Cobleigh, M., Shenkier, T., Edgerton, S. & Miller, K. D., Oct 1 2008, In : Journal of Clinical Oncology. 26, 28, p. 4672-4678 7 p.

Research output: Contribution to journalArticle

522 Scopus citations

Creating and evaluating genetic tests predictive of drug response

Weiss, S. T., McLeod, H. L., Flockhart, D. A., Dolan, M. E., Benowitz, N. L., Johnson, J. A., Ratain, M. J. & Giacomini, K. M., Jul 2008, In : Nature Reviews Drug Discovery. 7, 7, p. 568-574 7 p.

Research output: Contribution to journalArticle

47 Scopus citations

CYP2D6 genotyping and the pharmacogenetics of tamoxifen

Flockhart, D., Jul 1 2008, In : Clinical Advances in Hematology and Oncology. 6, 7, p. 493-494 2 p.

Research output: Contribution to journalArticle

12 Scopus citations

Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: Combining inherited and tumor gene markers for prediction of tamoxifen resistance

Goetz, M. P., Suman, V. J., Couch, F. J., Ames, M. M., Rae, J. M., Erlander, M. G., Ma, X. J., Sgroi, D. C., Reynolds, C. A., Lingle, W. L., Weinshilboum, R. M., Flockhart, D. A., Desta, Z., Perez, E. A. & Ingle, J. N., Sep 15 2008, In : Clinical Cancer Research. 14, 18, p. 5864-5868 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Dental caries experience and association to risk indicators of remote rural populations

Cook, S. L., Martinez-Mier, E. A., Dean, J. A., Weddell, J. A., Sanders, B. J., Eggertsson, H., Ofner, S. & Yoder, K., Jul 1 2008, In : International Journal of Paediatric Dentistry. 18, 4, p. 275-283 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Drug interactions and pharmacogenomics in the treatment of breast cancer and depression

Henry, N. L., Stearns, V., Flockhart, D. A., Hayes, D. F. & Riba, M., Oct 2008, In : American Journal of Psychiatry. 165, 10, p. 1251-1255 5 p.

Research output: Contribution to journalArticle

76 Scopus citations

Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen

Ntukidem, N. I., Nguyen, A. T., Stearns, V., Rehman, M., Schott, A., Skaar, T., Jin, Y., Blanche, P., Li, L., Lemler, S., Hayden, J., Krauss, R. M., Desta, Z., Flockhart, D. A. & Hayes, D. F., May 30 2008, In : Clinical Pharmacology and Therapeutics. 83, 5, p. 702-710 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Estrogen receptor genotypes influence hot flash prevalence and composite score before and after tamoxifen therapy

Jin, Y., Hayes, D. F., Li, L., Robarge, J. D., Skaar, T. C., Philips, S., Nguyen, A., Schott, A., Hayden, J., Lemler, S., Storniolo, A. M., Flockhart, D. A. & Stearns, V., Dec 20 2008, In : Journal of Clinical Oncology. 26, 36, p. 5849-5854 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Pharmacokinetics of ibutilide in patients with heart failure due to left ventricular systolic dysfunction

Tisdale, J. E., Overholser, B. R., Sowinski, K. M., Wroblewski, H. A., Amankwa, K., Borzak, S., Kingery, J. R., Coram, R., Zipes, D. P., Flockhart, D. A. & Kovacs, R. J., Dec 2008, In : Pharmacotherapy. 28, 12, p. 1461-1470 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Prospective characterization of musculoskeletal symptoms in early stage breast cancer patients treated with aromatase inhibitors

Henry, N. L., Giles, J. T., Ang, D., Mohan, M., Dadabhoy, D., Robarge, J., Hayden, J., Lemler, S., Shahverdi, K., Powers, P., Li, L., Flockhart, D., Stearns, V., Hayes, D. F., Storniolo, A. M. & Clauw, D. J., Sep 1 2008, In : Breast Cancer Research and Treatment. 111, 2, p. 365-372 8 p.

Research output: Contribution to journalArticle

149 Scopus citations

Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients

Tavares, M., Goodson, J. M., Studen-Pavlovich, D., Yagiela, J. A., Navalta, L. A., Rogy, S., Rutherford, B., Gordon, S., Papas, A. S., Soncini, J., Chin, J. R., Dean, J., Jarrett, J. L., Mau, M. S., Moore, P. A., Boynes, S. G., Lemak, A. L., Abdulwahab, M., Elliott, M., Zovko, J. G. & 17 others, Rosenberg, M., Singh, M., Pradhan, N. S., Raybould, T. P., Mailhot, J. M., Rockman, R. A., Akins, H. T., Turner, J. B., Pfail, J. L., Vaulari, D. V., Ivanova, Y. K., Kleven, J., Pulgar-Vidal, O., Chan, J., Minnick, D. L., Martinez, G. & Henegar, A., Aug 2008, In : Journal of the American Dental Association. 139, 8, p. 1095-1104 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Scientific article the relationship between Acute otitis media and the anatomic form of the hard palate

Kim, J. S., Donovan, D. M., Blanchard, S. B., Kowolik, J. E. & Eckert, G. J., Dec 1 2008, In : Pediatric dentistry. 30, 1, p. 9-14 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

The development of pediatric dentistry in Indiana: a tradition of excellence.

Jones, J. E., Mar 1 2008, In : Journal (Indiana Dental Association). 87, 1, p. 76-77 2 p.

Research output: Contribution to journalArticle

VKORC1 polymorphims, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans

Limdi, N. A., Beasley, T. M., Crowley, M. R., Goldstein, J. A., Rieder, M. J., Flockhart, D. A., Arnett, D. K., Acton, R. T. & Liu, N., 2008, In : Pharmacogenomics. 9, 10, p. 1445-1458 14 p.

Research output: Contribution to journalArticle

87 Scopus citations
2007

Comparison of duloxetine, escitalopram, and sertraline effects on cytochrome P450 2D6 function in healthy volunteers

Preskorn, S. H., Greenblatt, D. J., Flockhart, D., Luo, Y., Perloff, E. S., Harmatz, J. S., Baker, B., Klick-Davis, A., Desta, Z. & Burt, T., Feb 1 2007, In : Journal of Clinical Psychopharmacology. 27, 1, p. 28-34 7 p.

Research output: Contribution to journalArticle

72 Scopus citations

Drug-drug interaction prediction: A Bayesian meta-analysis approach

Li, L., Yu, M., Chin, R., Lucksiri, A., Flockhart, D. A. & Hall, S. D., Sep 10 2007, In : Statistics in Medicine. 26, 20, p. 3700-3721 22 p.

Research output: Contribution to journalArticle

18 Scopus citations

Estimating a positive false discovery rate for variable selection in pharmacogenetic studies

Li, L., Hui, S., Pennello, G., Desta, Z., Todd, S., Nguyen, A. & Flockhart, D., Sep 1 2007, In : Journal of biopharmaceutical statistics. 17, 5, p. 883-902 20 p.

Research output: Contribution to journalArticle

1 Scopus citations

Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro

Destra, Z., Saussele, T., Ward, B., Blievernicht, J., Li, L., Klein, K., Flockhart, D. A. & Zanger, U. M., Jun 1 2007, In : Pharmacogenomics. 8, 6, p. 547-558 12 p.

Research output: Contribution to journalArticle

154 Scopus citations

Possible interethnic differences in quinidine-induced QT prolongation between healthy Caucasian and Korean subjects

Shin, J. G., Kang, W. K., Shon, J. H., Arefayene, M., Yoon, Y. R., Kim, K. A., Kim, D. I., Kim, D. S., Cho, K. H., Woosley, R. L. & Flockhart, D. A., Feb 1 2007, In : British Journal of Clinical Pharmacology. 63, 2, p. 206-215 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Predicting asparaginase-associated pancreatitis

Knoderer, H. M., Robarge, J. & Flockhart, D. A., Oct 15 2007, In : Pediatric Blood and Cancer. 49, 5, p. 634-639 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Qualifications of a pediatric dentist

Sanders, B., Jan 1 2007, In : Journal of Pediatric Rehabilitation Medicine. 1, 1, p. 35-36 2 p.

Research output: Contribution to journalArticle

The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

Goetz, M. P., Knox, S. K., Suman, V. J., Rae, J. M., Safgren, S. L., Ames, M. M., Visscher, D. W., Reynolds, C., Couch, F. J., Lingle, W. L., Weinshilboum, R. M., Fritcher, E. G. B., Nibbe, A. M., Desta, Z., Nguyen, A., Flockhart, D. A., Perez, E. A. & Ingle, J. N., Jan 1 2007, In : Breast Cancer Research and Treatment. 101, 1, p. 113-121 9 p.

Research output: Contribution to journalArticle

478 Scopus citations

The in vivo contamination of air-driven low-speed handpieces with prophylaxis angles

Herd, S., Chin, J., Palenik, C. J. & Ofner, S., Oct 2007, In : Journal of the American Dental Association. 138, 10, p. 1360-1365 6 p.

Research output: Contribution to journalArticle

11 Scopus citations