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2007

Tooth loss, dementia and neuropathology in the Nun Study

Stein, P. S., Desrosiers, M., Donegan, S. J., Yepes, J. F. & Kryscio, R. J., Oct 2007, In : Journal of the American Dental Association. 138, 10, p. 1314-1322 9 p.

Research output: Contribution to journalArticle

218 Scopus citations

Topiramate in the treatment of neuropathic pain in patients with cancer

Bendaly, E. A., Jordan, C. A., Staehler, S. S. & Rushing, D. A., Sep 2007, In : Supportive Cancer Therapy. 4, 4, p. 241-246 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Upper and lower system nasolacrimal duct stenosis secondary to paclitaxel

McCartney, E., Valluri, S., Rushing, D. & Burgett, R., Mar 1 2007, In : Ophthalmic Plastic and Reconstructive Surgery. 23, 2, p. 170-171 2 p.

Research output: Contribution to journalArticle

25 Scopus citations

Utilization of stainless steel crowns by general dentists and pediatric dental specialists in Indiana.

Kowolik, J., Kozlowski, D. & Jones, J. E., Jan 1 2007, In : Journal (Indiana Dental Association). 86, 2, p. 16-21 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
2006

Analysis of angiogenesis genes from paraffin-embedded breast tumor and lymph nodes

Schneider, B. P., Skaar, T. C., Sledge, G. W., Badve, S., Li, L. & Flockhart, D. A., Apr 2006, In : Breast Cancer Research and Treatment. 96, 3, p. 209-215 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Endothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy

Sandrim, V. C., Yugar-Toledo, J. C., Desta, Z., Flockhart, D. A., Moreno, H. & Tanus-Santos, J. E., Dec 2006, In : Journal of Hypertension. 24, 12, p. 2393-2397 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells

Young, C. L., Li, L., Desta, Z., Zhao, Q., Rae, J. M., Flockhart, D. A. & Skaar, T. C., Jul 20 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 2, p. 503-512 10 p.

Research output: Contribution to journalArticle

121 Scopus citations

Internal contamination of air-driven low-speed handpieces and attached prophy angles

Chin, J. R., Miller, C. H. & Palenik, C. J., Sep 2006, In : Journal of the American Dental Association. 137, 9, p. 1275-1280 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Phase II study of intravenous TZT-1027 in patients with advanced or metastatic soft-tissue sarcomas with prior exposure to anthracycline-based chemotherapy

Patel, S., Keohan, M. L., Saif, M. W., Rushing, D., Baez, L., Feit, K., DeJager, R. & Anderson, S., Dec 15 2006, In : Cancer. 107, 12, p. 2881-2887 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment

Borges, S., Desta, Z., Li, L., Skaar, T. C., Ward, B. A., Nguyen, A., Jin, Y., Storniolo, A. M., Nikoloff, D. M., Wu, L., Hillman, G., Hayes, D. F., Stearns, V. & Flockhart, D. A., Jul 1 2006, In : Clinical Pharmacology and Therapeutics. 80, 1, p. 61-74 14 p.

Research output: Contribution to journalArticle

400 Scopus citations

The disposition of reduced haloperidol and HPP,+ metabolites of haloperidol, is not influenced by P-glycoprotein

Shin, J. G., Lee, K. H., Leonessa, F., Clarke, R. & Flockhart, D. A., Dec 1 2006, In : Journal of Korean Society for Clinical Pharmacology and Therapeutics. 14, 1, p. 42-50 9 p.

Research output: Contribution to journalArticle

2005

Association between the CYP3A5 genotype and blood pressure

Ho, H., Pinto, A., Hall, S. D., Flockhart, D. A., Li, L., Skaar, T. C., Cadman, P., O'Connor, D. T., Wagner, U., Fineberg, N. S. & Weinberger, M. H., Feb 2005, In : Hypertension. 45, 2, p. 294-298 5 p.

Research output: Contribution to journalArticle

74 Scopus citations

Consensus statement: Expedition Inspiration 2004 Breast Cancer Symposium 'Breast Cancer - The Development and Validation of New Therapeutics'

Lippman, M. E., Benz, C., Chinnaiyan, A., Flockhart, D., Harris, A., Hudis, C., Osborne, C. K., Press, M. F., Rae, J., Sledge, G. W., Veer, L. V. T. & Wicha, M., Mar 2005, In : Breast Cancer Research and Treatment. 90, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

Jin, Y., Desta, Z., Stearns, V., Ward, B., Ho, H., Lee, K. H., Skaar, T., Storniolo, A. M., Li, L., Araba, A., Blanchard, R., Nguyen, A., Ullmer, L., Hayden, J., Lemler, S., Weinshilboum, R. M., Rae, J. M., Hayes, D. F. & Flockhart, D. A., Jan 5 2005, In : Journal of the National Cancer Institute. 97, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

782 Scopus citations

Endothelial nitric oxide synthase gene haplotypes associated with circulating concentrations of nitric oxide products in healthy men

Metzger, I. F., Souza-Costa, D. C., Marroni, A. S., Nagassaki, S., Desta, Z., Flockhart, D. A. & Tanus-Santos, J. E., Aug 2005, In : Pharmacogenetics and Genomics. 15, 8, p. 565-570 6 p.

Research output: Contribution to journalArticle

92 Scopus citations
221 Scopus citations

Gastrointestinal stromal tumors: CT and MRI findings

Sandrasegaran, K., Rajesh, A., Rushing, D. A., Rydberg, J., Akisik, F. M. & Henley, J. D., Jul 2005, In : European Radiology. 15, 7, p. 1407-1414 8 p.

Research output: Contribution to journalArticle

143 Scopus citations

Gastrointestinal stromal tumors: Clinical, radiologic, and pathologic features

Sandrasegaran, K., Rajesh, A., Rydberg, J., Rushing, D. A., Akisik, F. M. & Henley, J. D., Jan 1 2005, In : American Journal of Roentgenology. 184, 3, p. 803-811 9 p.

Research output: Contribution to journalArticle

86 Scopus citations

Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes

Goetz, M. P., Rae, J. M., Suman, V. J., Safgren, S. L., Ames, M. M., Visscher, D. W., Reynolds, C., Couch, F. J., Lingle, W. L., Flockhart, D. A., Desta, Z., Perez, E. A. & Ingle, J. N., 2005, In : Journal of Clinical Oncology. 23, 36, p. 9312-9318 7 p.

Research output: Contribution to journalArticle

661 Scopus citations

The effects of tamoxifen and its metabolites on platelet function and release of reactive oxygen intermediates

Vitseva, O., Flockhart, D. A., Jin, Y., Varghese, S. & Freedman, J. E., Mar 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 3, p. 1144-1150 7 p.

Research output: Contribution to journalArticle

32 Scopus citations
2004

Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro

Ward, B. A., Morocho, A., Kandil, A., Galinsky, R. E., Flockhart, D. A. & Desta, Z., Sep 2004, In : British Journal of Clinical Pharmacology. 58, 3, p. 277-287 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6

Desta, Z., Ward, B. A., Soukhova, N. V. & Flockhart, D. A., Sep 2004, In : Journal of Pharmacology and Experimental Therapeutics. 310, 3, p. 1062-1075 14 p.

Research output: Contribution to journalArticle

478 Scopus citations

CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes

Ramírez, J., Innocenti, F., Schuetz, E. G., Flockhart, D. A., Relling, M. V., Santucci, R. & Ratain, M. J., Sep 1 2004, In : Drug Metabolism and Disposition. 32, 9, p. 930-936 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis

Takada, K., Arefayene, M., Desta, Z., Yarboro, C. H., Boumpas, D. T., Balow, J. E., Flockhart, D. A. & Illei, G. G., Jul 1 2004, In : Arthritis and Rheumatism. 50, 7, p. 2202-2210 9 p.

Research output: Contribution to journalArticle

134 Scopus citations

Human sympathetic activation by α 2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism

Le Corre, P., Parmer, R. J., Kailasam, M. T., Kennedy, B. P., Skaar, T. P., Ho, H., Leverge, R., Smith, D. W., Ziegler, M. G., Insel, P. A., Schork, N. J., Flockhart, D. A. & O'Connor, D. T., Aug 1 2004, In : Clinical Pharmacology and Therapeutics. 76, 2, p. 139-153 15 p.

Research output: Contribution to journalArticle

36 Scopus citations

Induction of testosterone metabolism by esomeprazole in a CYP2C19*2 heterozygote

Rosenshein, B., Flockhart, D. A. & Ho, H., May 2004, In : American Journal of the Medical Sciences. 327, 5, p. 289-293 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Intramuscular haloperidol or lorazepam and QT intervals in schizophrenia

Harvey, A. T., Flockhart, D., Gorski, J. C., Greenblatt, D. J., Burke, M., Werder, S. & Preskorn, S. H., Oct 1 2004, In : Journal of Clinical Pharmacology. 44, 10, p. 1173-1184 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen

Johnson, M. D., Zuo, H., Lee, K. H., Trebley, J. P., Rae, J. M., Weatherman, R. V., Desta, Z., Flockhart, D. A. & Skaar, T. C., May 1 2004, In : Breast Cancer Research and Treatment. 85, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

358 Scopus citations

QT analysis: A complex answer to a 'simple' problem

Li, L., Desai, M., Desta, Z. & Flockhart, D., Sep 15 2004, In : Statistics in Medicine. 23, 17, p. 2625-2643 19 p.

Research output: Contribution to journalArticle

16 Scopus citations

Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine (multiple letters) [1]

Ratliff, B., Dietze, E. C., Bean, G. R., Moore, C., Wanko, S., Seewaldt, V. L., Ponzone, R., Biglia, N., Sismondi, P., Lien, E. A., Ueland, P. M., Løonning, P. E., Stearns, V., Johnson, M. D., Rae, J. M., Novielli, A., Bhargava, P., Hayes, D. F., Desta, Z. & Flockhart, D. A., Jun 2 2004, In : Journal of the National Cancer Institute. 96, 11, p. 883-885 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

The effect of glove contamination on the bond strength of resin to enamel

Sanders, B. J., Pollock, A., Weddell, J. A. & Moore, K., Jan 1 2004, In : Journal of Clinical Pediatric Dentistry. 28, 4, p. 339-341 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2003

Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine

Stearns, V., Johnson, M. D., Rae, J., Morocho, A., Novielli, A., Bhargava, P., Hayes, D. F., Desta, Z. & Flockhart, D. A., Dec 3 2003, In : Journal of the National Cancer Institute. 95, 23, p. 1758-1764 7 p.

Research output: Contribution to journalArticle

717 Scopus citations

Cytochrome P450 3A pharmacogenetics: The road that needs traveled

Flockhart, D. A. & Rae, J. M., Apr 24 2003, In : Pharmacogenomics Journal. 3, 1, p. 3-5 3 p.

Research output: Contribution to journalArticle

36 Scopus citations

Genotyping for polymorphic drug metabolizing enzymes from paraffin-embedded and immunohistochemically stained tumor samples

Rae, J. M., Cordero, K. E., Scheys, J. O., Lippman, M. E., Flockhart, D. A. & Johnson, M. D., Aug 1 2003, In : Pharmacogenetics. 13, 8, p. 501-507 7 p.

Research output: Contribution to journalArticle

54 Scopus citations

High-Level Expression of EphA2 Receptor Tyrosine Kinase in Prostatic Intraepithelial Neoplasia

Zeng, G., Hu, Z., Kinch, M. S., Pan, C. X., Flockhart, D. A., Kao, C., Gardner, T. A., Zhang, S., Li, L., Baldridge, L. A., Koch, M. O., Ulbright, T. M., Eble, J. N. & Cheng, L., Dec 2003, In : American Journal of Pathology. 163, 6, p. 2271-2276 6 p.

Research output: Contribution to journalArticle

92 Scopus citations

Improving the quality of adverse drug reaction reporting by 4th-year medical students

Rosebraugh, C. J., Tsong, Y., Zhou, F., Chen, M., Mackey, A. C., Flowers, C., Toyer, D., Flockhart, D. A. & Honig, P. K., Mar 2003, In : Pharmacoepidemiology and Drug Safety. 12, 2, p. 97-101 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pharmacokinetics and QT interval pharmacodynamics of oral haloperidol in poor and extensive metabolizers of CYP2D6

Desai, M., Tanus-Santos, J. E., Li, L., Gorski, J. C., Arefayene, M., Liu, Y., Desta, Z. & Flockhart, D. A., Jun 17 2003, In : Pharmacogenomics Journal. 3, 2, p. 105-113 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Private practice pediatric dentists in Indiana: location and longevity.

De Ball, S., Baumgartner, M. & Kowolik, J. E., Jan 1 2003, In : Journal (Indiana Dental Association). 82, 4, p. 16-20 5 p.

Research output: Contribution to journalArticle

85 Scopus citations

Sequence diversity and functional characterization of the 5′-regulatory region of human CYP2C19

Arefayene, M., Skaar, T. C., Zhao, X., Rae, J. M., Tanus-Santos, J. E., Brinkmann, U., Brehm, I., Salat, U., Nguyen, A., Desta, Z. & Flockhart, D. A., Apr 1 2003, In : Pharmacogenetics. 13, 4, p. 199-206 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
469 Scopus citations

Variability of heart rate correction methods for the QT interval

Desai, M., Li, L., Desta, Z., Malik, M. & Flockhart, D., Jun 1 2003, In : British Journal of Clinical Pharmacology. 55, 6, p. 511-517 7 p.

Research output: Contribution to journalArticle

74 Scopus citations
2002

Antibacterial and physical properties of resin modified glass-ionomers combined with chlorhexidine

Sanders, B. J., Gregory, R. L., Moore, K. & Avery, D. R., Jun 1 2002, In : Journal of Oral Rehabilitation. 29, 6, p. 553-558 6 p.

Research output: Contribution to journalArticle

60 Scopus citations

Association between CYP2D6 genotype and tardive dyskinesia in Korean schizophrenics

Nikoloff, D., Shim, J. C., Fairchild, M., Patten, N., Fijal, B. A., Koch, W. H., MacPherson, A., Flockhart, D., Yoon, Y. R., Yoon, J. S., Kim, Y. H. & Shin, J. G., Dec 1 2002, In : Pharmacogenomics Journal. 2, 6, p. 400-407 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Comparison of electrosurgical and formocresol pulpotomy procedures in children

Dean, J. A., Mack, R. B., Fulkerson, B. T. & Sanders, B. J., May 1 2002, In : International Journal of Paediatric Dentistry. 12, 3, p. 177-182 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol

Tanus-Santos, J. E., Desai, M., Deak, L. R., Pezzullo, J. C., Abernethy, D. R., Flockhart, D. A. & Freedman, J. E., 2002, In : Pharmacogenetics. 12, 5, p. 407-413 7 p.

Research output: Contribution to journalArticle

90 Scopus citations

Inhibitory effects of tricyclic antidepressants (TCAs) on human cytochrome P450 enzymes in vitro: Mechanism of drug interaction between TCAs and phenytoin

Shin, J. G., Park, J. Y., Kim, M. J., Shon, J. H., Yoon, Y. R., Cha, I. J., Lee, S. S., Oh, S. W., Kim, S. W. & Flockhart, D. A., Oct 1 2002, In : Drug Metabolism and Disposition. 30, 10, p. 1102-1107 6 p.

Research output: Contribution to journalArticle

65 Scopus citations

In vitro inhibition of pimozide N-dealkylation by selective serotonin reuptake inhibitors and azithromycin

Desta, Z., Soukhova, N. & Flockhart, D. A., 2002, In : Journal of Clinical Psychopharmacology. 22, 2, p. 162-168 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pharmacokinetics and biochemical effects of hepapoietin in patients with chronic liver disease

Marino, G., Rustgi, V. K., Salzberg, G., Johnson, L. B., Kuo, P. C., Plotkin, J. S. & Flockhart, D. A., Feb 26 2002, In : Alimentary Pharmacology and Therapeutics. 16, 2, p. 235-242 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Pharmacokinetics of fluvoxamine in relation to CYP2C19 phenotype and genotype

Jann, M. W., ZumBrunnen, T. L., Kazmi, Y. R., VanDenBerg, C. M., Desai, H. D., Weidler, D. J. & Flockhart, D. A., Oct 9 2002, In : Drug Metabolism and Drug Interactions. 19, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

12 Scopus citations