Publications

Filter
Article
2002

Single isomer versus racemate: Is there a difference? Clinical comparisons in allergy and gastroenterology

Flockhart, D. A. & Nelson, H. S., 2002, In : CNS Spectrums. 7, 4 SUPPL. 1, p. 23-27 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Teaching rational prescribing: A new clinical pharmacology curriculum for medical schools

Flockhart, D. A., Yasuda, S. U., Pezzullo, J. C. & Knollmann, B. C., Jun 26 2002, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 366, 1, p. 33-43 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6

Desta, Z., Wu, G. M., Morocho, A. M. & Flockhart, D. A., 2002, In : Drug Metabolism and Disposition. 30, 3, p. 336-343 8 p.

Research output: Contribution to journalArticle

88 Scopus citations
2001

Appliance for chronic drooling in cerebral palsy patients

Inga, C. J., Reddy, A. K., Richardson, S. A. & Sanders, B., Dec 1 2001, In : Pediatric dentistry. 23, 3, p. 241-242 2 p.

Research output: Contribution to journalArticle

13 Scopus citations

Characterization of tamoxifen metabolism to a novel, putative active metabolite

Morocho, A. M., Desta, Z., Wu, G. M., Soukova, N. V., Rae, J. M. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P68

Research output: Contribution to journalArticle

2 Scopus citations

Cloning and sequencing of 5′-regulatory region of CYP2C19

Zhao, X., Rae, J. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P72

Research output: Contribution to journalArticle

1 Scopus citations

Coprescription of paroxetine with tamoxifen to reduce hot flashes reduced plasma 4-hydroxy-N-desmethyl-tamoxifen plasma concentrations in a CYP2D6-dependent manner

Flockhart, D. A., Hayes, D. F., Rae, J. M., Bhargava, P., Morocho, A. & Stearns, V., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P10

Research output: Contribution to journalArticle

Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants

Tanus-Santos, J. E., Desai, M. & Flockhart, D. A., 2001, In : Pharmacogenetics. 11, 8, p. 719-725 7 p.

Research output: Contribution to journalArticle

248 Scopus citations

Improving the quality of adverse drug reaction reporting by 4th year medical students with a 15-minute intervention

Rosebraugh, C. J., Honig, P. K., Corken, A., Flowers, C., Mease, M., Toyer, D., Chen, M. & Flockhart, D. A., Jan 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P93

Research output: Contribution to journalArticle

1 Scopus citations

Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: Potent inhibition of CYP2C19 and CYP3A

Desta, Z., Soukhova, N. V. & Flockhart, D. A., Feb 8 2001, In : Antimicrobial Agents and Chemotherapy. 45, 2, p. 382-392 11 p.

Research output: Contribution to journalArticle

133 Scopus citations

In vitro inhibition of pimozide N-dealkylation by selective serotonin reuptake inhibitors (SSRIS) antidepressants and azithromycin

Desta, Z., Soukhova, N. V. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P9

Research output: Contribution to journalArticle

In vitro inhibition of tricyclic antidepressants (TCAs) on phenytoin P-hydroxylation: Involvement of CYP2C9 and CYP2C19

Park, J. Y., Shon, J. H., Kim, M. J., Cha, I. J., Flockhart, D. A. & Shin, J. G., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P78

Research output: Contribution to journalArticle

Mechanism-based inactivation of CYP2C19 and CYP2D6 by tamoxifen (TAM) and its metabolite n-desmethyltamoxifen (NDTAM)

Desta, Z., Park, J., Soukhova, N. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P9

Research output: Contribution to journalArticle

1 Scopus citations

Microarray analysis of drug metabolizing enzyme induction in primary hepatocyte cultures

Rae, J. M., Johnson, M. D., Lippman, M. E. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P64

Research output: Contribution to journalArticle

National survey of clinical pharmacology (CP) education in medical schools and internal medicine residency programs

Rosebraugh, C. J., Yasuda, S. U., Pezzullo, J. C., Honig, P. K., Flockhart, D. A. & Woosley, R. L., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P93

Research output: Contribution to journalArticle

Olanzapine-induced rhabdomyolysis

Rosebraugh, C. J., Flockhart, D. A., Yasuda, S. U. & Woosley, R. L., Jan 1 2001, In : Annals of Pharmacotherapy. 35, 9, p. 1020-1023 4 p.

Research output: Contribution to journalArticle

29 Scopus citations

Potent inhibition of CYP2D6 by haloperidol metabolites: Stereoselective inhibition by reduced haloperidol

Shin, J. G., Kane, K. & Flockhart, D. A., Feb 15 2001, In : British Journal of Clinical Pharmacology. 51, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: Studies with cDNA and oligonucleotide expression arrays

Rae, J. M., Johnson, M. D., Lippman, M. E. & Flockhart, D. A., Dec 12 2001, In : Journal of Pharmacology and Experimental Therapeutics. 299, 3, p. 849-857 9 p.

Research output: Contribution to journalArticle

258 Scopus citations

Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: Major role of CYP3A

Desta, Z., Soukhova, N., Morocho, A. M. & Flockhart, D. A., Aug 2 2001, In : Journal of Pharmacology and Experimental Therapeutics. 298, 2, p. 508-520 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice

Desta, Z., Kivistö, K. T., Lilja, J. J., Backman, J. T., Soukhova, N., Neuvonen, P. J. & Flockhart, D. A., 2001, In : British Journal of Clinical Pharmacology. 52, 4, p. 399-407 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

The effect of tamoxifen and its metabolites on platelet function and nitric oxide release

Deak, L. R., Burack, V., Flockhart, D. & Freedman, J. E., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P32

Research output: Contribution to journalArticle

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6

Wu, G. M., Desta, Z., Morocho, A. M. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P71

Research output: Contribution to journalArticle

Visual hallucination and tremor induced by sertraline and oxycodone in a bone marrow transplant patient

Rosebraugh, C. J., Flockhart, D. A., Yasuda, S. U. & Woosley, R. L., Feb 8 2001, In : Journal of clinical pharmacology. 41, 2, p. 224-227 4 p.

Research output: Contribution to journalArticle

34 Scopus citations
2000

A discordance of the cytochrome P450 2C19 genotype and phenotype patients with advanced cancer

Williams, M. L., Bhargava, P., Cherrouk, I., Marshall, J. L., Flockhart, D. A. & Wainer, I. W., May 10 2000, In : British Journal of Clinical Pharmacology. 49, 5, p. 485-488 4 p.

Research output: Contribution to journalArticle

64 Scopus citations

Greater quinidine-induced QTc interval prolongation in women

Benton, R. E., Sale, M., Flockhart, D. A. & Woosley, R. L., Jan 1 2000, In : Clinical Pharmacology and Therapeutics. 67, 4, p. 413-418 6 p.

Research output: Contribution to journalArticle

123 Scopus citations

Interaction of cisapride with the human cytochrome P450 system: Metabolism and inhibition studies

Desta, Z., Soukhova, N., Mahal, S. K. & Flockhart, D. A., Aug 2 2000, In : Drug Metabolism and Disposition. 28, 7, p. 789-800 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: Potent effect on CYP2C19 and CYP2D6

Ko, J. W., Desta, Z., Soukhova, N. V., Tracy, T. & Flockhart, D. A., Apr 20 2000, In : British Journal of Clinical Pharmacology. 49, 4, p. 343-351 9 p.

Research output: Contribution to journalArticle

92 Scopus citations

In vitro metabolism and interaction of cilostazol with human hepatic cytochrome P450 isoforms

Abbas, R., Chow, C. P., Browder, N. J., Thacker, D., Bramer, S. L., Fu, C. J., Forbes, W., Odomi, M. & Flockhart, D. A., Jan 1 2000, In : Human and Experimental Toxicology. 19, 3, p. 178-184 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Molecular basis of cardiovascular drug metabolism: Implications for predicting clinically important drug interactions

Abernethy, D. R. & Flockhart, D. A., Apr 11 2000, In : Circulation. 101, 14, p. 1749-1753 5 p.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations

Phase I/II study of weekly irinotecan and paclitaxel in patients with SCLC

Rushing, D. A., Dec 1 2000, In : ONCOLOGY. 14, 7 SUPPL. 5, p. 63-66 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Phase II evaluation of thalidomide in patients with metastatic breast cancer

Baidas, S. M., Winer, E. P., Fleming, G. F., Harris, L., Pluda, J. M., Crawford, J. G., Yamauchi, H., Isaacs, C., Hanfelt, J., Tefft, M., Flockhart, D., Johnson, M. D., Hawkins, M. J., Lippman, M. E. & Hayes, D. F., Jul 2000, In : Journal of Clinical Oncology. 18, 14, p. 2710-2717 8 p.

Research output: Contribution to journalArticle

109 Scopus citations

Relationship of paroxetine disposition to metoprolol metabolic ratio and CYP2D6*10 genotype of Korean subjects

Yoon, Y. R., Cha, I. J., Shon, J. H., Kim, K. A., Cha, Y. N., Jang, I. J., Park, C. W., Shin, S. G., Flockhart, D. A. & Shin, J. G., Jan 1 2000, In : Clinical Pharmacology and Therapeutics. 67, 5, p. 567-576 10 p.

Research output: Contribution to journalArticle

56 Scopus citations
15 Scopus citations

Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with Tourette syndrome

Flockhart, D. A., Drici, M. D., Kerbusch, T., Soukhova, N., Richard, E., Pearle, P. L., Mahal, S. K. & Babb, V. J., Jun 1 2000, In : Journal of Clinical Psychopharmacology. 20, 3, p. 317-324 8 p.

Research output: Contribution to journalArticle

66 Scopus citations
1999

Allelic, genotypic and phenotypic distributions of S-mephenytoin 4'-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world

Xie, H. G., Stein, C. M., Kim, R. B., Wilkinson, G. R., Flockhart, D. A. & Wood, A. J. J., Dec 14 1999, In : Pharmacogenetics. 9, 5, p. 539-549 11 p.

Research output: Contribution to journalArticle

161 Scopus citations

A pilot study of melphalan, tumor necrosis factor-α and 41.8 °C whole- body hyperthermia

Robins, H. I., Katschinski, D. M., Longo, W., Grosen, E., Wilding, G., Gillis, W., Kraemer, C., Tiggelaar, C. L., Rushing, D., Stewart, J. A., Spriggs, D., Love, R., Arzoomanian, R. Z., Feierabend, C., Alberti, D., Morgan, K., Simon, K. & D'Oleire, F., Mar 18 1999, In : Cancer Chemotherapy and Pharmacology. 43, 5, p. 409-414 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: Preferential inhibition of CYP2D6

Shin, J. G., Soukhova, N. & Flockhart, D. A., Sep 7 1999, In : Drug Metabolism and Disposition. 27, 9, p. 1078-1084 7 p.

Research output: Contribution to journalArticle

140 Scopus citations
99 Scopus citations

Haloperidol metabolites inhibit CYP2D6 catalyzed dextromethorphan O-demethylation in vitro

Shin, J. G., Kane, K. & Flockhart, D. A., Jan 1 1999, In : Clinical Pharmacology and Therapeutics. 65, 2, 1 p.

Research output: Contribution to journalArticle

Identification and characterization of human cytchrome P450 (CYP) isoforms interacting with cisapride

Desta, Z., Thacker, D., Soukhova, N., Shin, J. G. & Flockhart, D. A., Jan 1 1999, In : Clinical Pharmacology and Therapeutics. 65, 2, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Metabolism of an anabolic androgenic steroid, oxymetholone by human cytochrome P450s

Thacker, D. L., Wainer, I., Lerch, C., Fried, K. & Flockhart, D. A., Jan 1 1999, In : Clinical Pharmacology and Therapeutics. 65, 2, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Multi-drug resistance in chronic lymphocytic leukemia

Friedenberg, W. R., Spencer, S. K., Musser, C., Hogan, T. F., Rodvold, K. A., Rushing, D. A., Mazza, J. J., Tewksbury, D. A. & Marx, J. J., 1999, In : Leukemia and Lymphoma. 34, 1-2, p. 171-178 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Reduced CYP2C19 activity in cancer patients

Williams, M. L., Bhargava, P., Marshall, J. L., Flockhart, D. A. & Wainer, I. W., Jan 1 1999, In : Clinical Pharmacology and Therapeutics. 65, 2, 1 p.

Research output: Contribution to journalArticle

Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers

Ko, J. W., Jang, I. J., Shin, J. G., Nam, S. K., Shin, S. G. & Flockhart, D. A., Jul 5 1999, In : Clinical Pharmacology and Therapeutics. 65, 6, p. 606-614 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Ticlopidine inhibits phenytoin clearance

Donahue, S., Flockhart, D. A. & Abernethy, D. R., 1999, In : Clinical Pharmacology and Therapeutics. 66, 6, p. 563-568 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
1998

Blue-chip technology

Flockhart, D. A. & Webb, D. J., 1998, In : Lancet. 352, SUPPL.4, p. SIV2

Research output: Contribution to journalArticle

3 Scopus citations

Effect of CYP3A inhibition on vesnarinone metabolism in humans

Wandel, C., Lang, C. C., Cowart, D. C., Girard, A. F., Bramer, S., Flockhart, D. A. & Wood, A. J. J., May 1 1998, In : Clinical Pharmacology and Therapeutics. 63, 5, p. 506-511 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
5 Scopus citations

Human N-demethylation of (S)-mephenytoin by cytochrome P450S 2C9 and 2B6

Ko, J. W., Desta, Z. & Flockhart, D. A., Aug 1 1998, In : Drug Metabolism and Disposition. 26, 8, p. 775-778 4 p.

Research output: Contribution to journalArticle

60 Scopus citations