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1998

Identification and characterization of human cytochrome P450 isoforms interacting with pimozide

Desta, Z., Kerbusch, T., Soukhova, N., Richard, E., Ko, J. W. & Flockhart, D. A., Jan 1 1998, In : Journal of Pharmacology and Experimental Therapeutics. 285, 2, p. 428-437 10 p.

Research output: Contribution to journalArticle

66 Scopus citations

Method for the determination of 5,5-diphenylbarbituric acid and its separation from 1,3-dimethoxymethyl-5,5-diphenylbarbituric acid in plasma by high-performance liquid chromatography

Thacker, D. L., Abernethy, D. R., Raines, A. & Flockhart, D. A., Jun 12 1998, In : Journal of Chromatography B: Biomedical Applications. 710, 1-2, p. 149-155 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Prolongation of QT interval in isolated feline hearts by antipsychotic drugs

Drici, M. D., Wang, W. X., Liu, X. K., Woosley, R. L. & Flockhart, D. A., Dec 1 1998, In : Journal of Clinical Psychopharmacology. 18, 6, p. 477-481 5 p.

Research output: Contribution to journalArticle

133 Scopus citations

Thalidomide does not alter the pharmacokinetics of ethinyl estradiol and norethindrone

Trapnell, C. B., Donahue, S. R., Collins, J. M., Flockhart, D. A., Thacker, D. & Abernethy, D. R., Dec 1 1998, In : Clinical Pharmacology and Therapeutics. 64, 6, p. 597-602 6 p.

Research output: Contribution to journalArticle

22 Scopus citations
1997

Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms

Ko, J. W., Sukhova, N., Thacker, D., Chen, P. & Flockhart, D. A., Dec 1 1997, In : Clinical Pharmacology and Therapeutics. 61, 2, 1 p.

Research output: Contribution to journalArticle

Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms

Ko, J. W., Sukhova, N., Thacker, D., Chen, P. & Flockhart, D. A., Jul 1997, In : Drug Metabolism and Disposition. 25, 7, p. 853-862 10 p.

Research output: Contribution to journalArticle

196 Scopus citations

Inhibition of IL-12 Production by Thalidomide

Moller, D. R., Wysocka, M., Greenlee, B. M., Ma, X., Wahl, L., Flockhart, D. A., Trinchieri, G. & Karp, C. L., Nov 15 1997, In : Journal of Immunology. 159, 10, p. 5157-5161 5 p.

Research output: Contribution to journalArticle

202 Scopus citations

Metabolism of pimozide by CYF3A and CYP2D6 in human liver microsomes

Flockhart, D. A., Richard, E., Soukova, N. & Kerbuscb, T., Dec 1 1997, In : Clinical Pharmacology and Therapeutics. 61, 2, 1 p.

Research output: Contribution to journalArticle

Phase I clinical trial of melphalan and 41.8°C whole-body hyperthermia in cancer patients

Robins, H. I., Rushing, D., Kutz, M., Tutsch, K. D., Tiggelaar, C. L., Paul, D., Spriggs, D., Kraemer, C., Gillis, W., Feierabend, C., Arzoomanian, R. Z., Longo, W., Alberti, D., d'Oleire, F., Qu, R. P., Wilding, G. & Stewart, J. A., Jan 1997, In : Journal of Clinical Oncology. 15, 1, p. 158-164 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Sensitive assay for pimozide in human plasma using high-performance liquid chromatography with fluorescence detection: Application to pharmacokinetic studies

Kerbusch, T., Desta, Z., Soukhova, N. V., Thacker, D. & Flockhart, D. A., Jun 20 1997, In : Journal of Chromatography B: Biomedical Applications. 694, 1, p. 163-168 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Synergistic effects of ketoconazole and pimozide on QT interval in isolated rabbit hearts: Influence of gender and pacing rate

Wang, W. X., Flockhart, D., Drici, M. D. & Woosley, R. L., Dec 1 1997, In : Clinical Pharmacology and Therapeutics. 61, 2, 1 p.

Research output: Contribution to journalArticle

Thalidomide pharmacokinetics do not change with chronic administration

Donahue, S. R., Collins, J. M., Flockhart, D. A., Abernethy, D. R. & Trapnell, C. B., Dec 1 1997, In : Clinical Pharmacology and Therapeutics. 61, 2, 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

The effect of sleep on conscious sedation: A follow-up study

Sanders, B. J., Dec 1 1997, In : Journal of Clinical Pediatric Dentistry. 21, 2, p. 131-134 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

The incidence of genetic polymorphisms of CYP 2C in a Korean population

Ko, J. W., Macpherson, A. S., Jang, I. J., Shin, S. G. & Flockhart, D. A., Dec 1 1997, In : Clinical Pharmacology and Therapeutics. 61, 2, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

The use of sealants by Indiana dentists.

Sanders, B. J. & Smith, C. E., Jan 1 1997, In : Journal (Indiana Dental Association). 76, 1, p. 11-12, 14

Research output: Contribution to journalArticle

1 Scopus citations

Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19

Donahue, S. K., Flockhart, D. A., Abernethy, D. R. & Ko, J. W., Nov 1 1997, In : Clinical Pharmacology and Therapeutics. 62, 5, p. 572-577 6 p.

Research output: Contribution to journalArticle

62 Scopus citations
1996

Bioavailability and efficacy of omeprazole given orally and by nasogastric tube

Larson, C., Cavuto, N. J., Flockhart, D. A. & Weinberg, R. B., Apr 15 1996, In : Digestive diseases and sciences. 41, 3, p. 475-479 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Conversion of dimethoxymethyl-diphenylbarbituric acid (DMMDPB) to diphenylbarbituric acid (DPB) in the rat

Raines, A., Flockhart, D., Dretchen, K. L., Singh, A., Thacker, D., Yacobi, A., Moros, D., Levitt, B. H. & Abernethy, D., Dec 1 1996, In : FASEB Journal. 10, 3, p. A155

Research output: Contribution to journalArticle

Determination of CYP2C19 phenotype in black Americans with omeprazole: Correlation with genotype

Marinac, J. S., Balian, J. D., Foxworth, J. W., Willsie, S. K., Daus, J. C., Owen, R. & Flockhart, D. A., Aug 1 1996, In : Clinical Pharmacology and Therapeutics. 60, 2, p. 138-144 7 p.

Research output: Contribution to journalArticle

54 Scopus citations
1995

A multicenter, multiple dose, open label study of the initiation of sustained-release morphine sulfate (SRMS) in chronic pain

Ritch, P., Plezia, P., Rushing, D., Heilman, R., Finn, J., Andresen, S., Schobelock, M., Mosdell, K. & Shepard, K., Jul 1995, In : American Journal of Hospice and Palliative Medicine. 12, 4, p. 18-23 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Drug Interactions and the Cytochrome P450 System: The Role of Cytochrome P450 2C19

Flockhart, D. A., Nov 1995, In : Clinical Pharmacokinetics. 29, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

79 Scopus citations

Managing patients who have seizure disorders: dental and medical issues.

Sanders, B. J., Weddell, J. A. & Dodge, N. N., Dec 1995, In : Journal of the American Dental Association (1939). 126, 12, p. 1641-1647 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

P450 metabolism in fibromyalgia

Clauw, D. J., Hewett, J., Blank, C. A., Katz, P. & Flockhart, D. A., Jan 1 1995, In : Journal of Musculoskeletal Pain. 3, 4, p. 25-32 8 p.

Research output: Contribution to journalArticle

S-Mephenytoin hydroxylation phenotypes in a Jordanian population

Hadidi, H. F., Irshaid, Y. M., Woosley, R. L., Idle, J. R. & Flockhart, D. A., Nov 1995, In : Clinical Pharmacology and Therapeutics. 58, 5, p. 542-547 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: A population study

Balian, J. D., Sukhova, N., Harris, J. W., Hewett, J., Pickle, L., Goldstein, J. A., Woosley, R. L. & Flockhart, D. A., Jun 1995, In : Clinical Pharmacology and Therapeutics. 57, 6, p. 662-669 8 p.

Research output: Contribution to journalArticle

165 Scopus citations
1994

Eosinophilia-myalgia syndrome not associated with the ingestion of nutritional supplements

Clauw, D. J., Flockhart, D. A., Mullins, W., Katz, P. & Medsger, T. A., Dec 1 1994, In : Journal of Rheumatology. 21, 12, p. 2385-2387 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Pharmacogenetic characteristics of the eosinophilia‐myalgia syndrome

Flockhart, D. A., Clauw, D. J., Sale, E. B., Hewett, J. & Woosley, R. L., Oct 1994, In : Clinical Pharmacology & Therapeutics. 56, 4, p. 398-405 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

The effect of sleep on conscious sedation.

Sanders, B. J., Potter, R. H. & Avery, D. R., Mar 1 1994, In : The Journal of clinical pediatric dentistry. 18, 3, p. 211-214 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

The effects of cyclosporine on the pharmacokinetics of doxorubicin in patients with small cell lung cancer

Rushing, D. A., Raber, S. R., Rodvold, K. A., Piscitelli, S. C., Plank, G. S. & Tewksbury, D. A., Aug 1 1994, In : Cancer. 74, 3, p. 834-841 8 p.

Research output: Contribution to journalArticle

67 Scopus citations
1993

Pharmacokinetics and pharmacodynamics of doxorubicin in patients with small cell lung cancer

Piscitelli, S. C., Rodvold, K. A., Rushing, D. A. & Tewksbury, D. A., May 1993, In : Clinical Pharmacology & Therapeutics. 53, 5, p. 555-561 7 p.

Research output: Contribution to journalArticle

106 Scopus citations

Phase I clinical trial of carboplatin and 41.8°C whole-body hyperthermia in cancer patients

Robins, H. I., Cohen, J. D., Schmitt, C. L., Tutsch, K. D., Feierabend, C., Arzoomanian, R. Z., Alberti, D., D'Oleire, F., Longo, W., Heiss, C., Rushing, D., Love, R. & Spriggs, D., 1993, In : Journal of Clinical Oncology. 11, 9, p. 1787-1794 8 p.

Research output: Contribution to journalArticle

78 Scopus citations

The Disposition of Doxorubicin on Repeated Dosing

Rushing, D. A., Piscitelli, S. C., Rodvold, K. A. & Tewksbury, D. A., Aug 1993, In : The Journal of Clinical Pharmacology. 33, 8, p. 698-702 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
1992

Alternative use of the electrical burn appliance.

Sanders, B. J., Hennon, D. K., Eppley, B. L., Sadove, A. M. & Zuker, R., Sep 1 1992, In : Pediatric dentistry. 14, 5, p. 345-346 2 p.

Research output: Contribution to journalArticle

1991

High‐dose carmustine and autologous bone marrow reinfusion in the treatment of refractory or relapsed small cell lung carcinoma

Rushing, D. A., Friedenberg, W. R., Baldauf, M. C., Broste, S., Gehlsen, J. A., Kriesel, D. H., Koontz, D. P. & Rodvold, K. A., Aug 15 1991, In : Cancer. 68, 4, p. 720-724 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
1990

Establishing special needs car seat loan program

Bull, M. J., Bruner Stroup, K., Stout, J., Doll, J. P., Jones, J. & Feller, N., Jan 1 1990, In : Pediatrics. 85, 4, p. 540-547 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
1988

Appliance therapy for perioral electrical burns: A conservative approach

Sadove, M. A., Jones, J. E., Lynch, T. R. & Sheets, P. W., Jul 1988, In : Journal of Burn Care and Rehabilitation. 9, 4, p. 391-395 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Doxorubicin clearance in the obese

Rodvold, K. A., Rushing, D. A. & Tewksbury, D. A., Jan 1 1988, In : Journal of Clinical Oncology. 6, 8, p. 1321-1327 7 p.

Research output: Contribution to journalArticle

169 Scopus citations

Hypoglycemia due to inadvertent dispensing of chlorpropamide

Gordon, M. R., Flockhart, D., Zawadzki, J. K., Taylor, T., Ramey, J. N. & Eastman, R. C., Aug 1988, In : The American Journal of Medicine. 85, 2, p. 271-272 2 p.

Research output: Contribution to journalArticle

17 Scopus citations
1987

Birooted primary canines

Jones, J. E. & Hazelrigg, C. O., Apr 1987, In : Oral Surgery, Oral Medicine, Oral Pathology. 63, 4, p. 499-500 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

General anesthesia in a malignant hyperthermia susceptible patient

Jones, J. E., Dierdorf, S. F. & Clapp, D. W., Jan 1 1987, In : Journal of Oral Medicine. 42, 1, p. 22-24+66

Research output: Contribution to journalArticle

1 Scopus citations
1986

Minimal-Change Nephrotic Syndrome Associated With Malignant Mesothelioma

Schroeter, N. J., Rushing, D. A., Parker, J. P. & Beltaos, E., Sep 1986, In : Archives of Internal Medicine. 146, 9, p. 1834-1836 3 p.

Research output: Contribution to journalArticle

19 Scopus citations
1985

Sublingual emphysema complicating dental anesthesia

Means, L. J., Jones, J. E. & Rao, C. C., 1985, In : Anesthesia and Analgesia. 64, 7, p. 737-738 2 p.

Research output: Contribution to journalArticle

3 Scopus citations
1984

ATP analog specificity of cAMP‐dependent protein kinase, cGMP‐dependent protein kinase, and phosphorylase kinase

FLOCKHART, D. A., FREIST, W., HOPPE, J., LINCOLN, T. M. & CORBIN, J. D., Apr 1984, In : European Journal of Biochemistry. 140, 2, p. 289-295 7 p.

Research output: Contribution to journalArticle

41 Scopus citations
1983

Removal of phosphate from proteins by the reverse reaction

Flockhart, D. A., Jan 1 1983, In : Methods in Enzymology. 99, C, p. 14-20 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
1982

Hydroxyurea versus busulfan in the treatment of chronic myelogenous leukemia

Rushing, D., Goldman, A., Gibbs, G., Howe, R. & Kennedy, B. J., Dec 1 1982, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 5, 3, p. 307-313 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Regulatory mechanisms in the control of protein kinase

Flockhart, D. A. & Corbin, J. D., Jan 1 1982, In : Critical Reviews in Biochemistry and Molecular Biology. 12, 2, p. 133-186 54 p.

Research output: Contribution to journalArticle

243 Scopus citations

Use of a feeding obturator for infants with severe cleft lip and palate

JONES, JAMES. E., HENDERSON, LORINE. & AVERY, DAVID. R., May 1982, In : Special Care in Dentistry. 2, 3, p. 116-120 5 p.

Research output: Contribution to journalArticle

21 Scopus citations
1981

Comparison of hydroxyurea (HYD) and busulfan (BUS) in chronic myelogenous leukemia (CML)

Rushing, D. A., Gibbs, G. E. & Howe, R. B., Jan 1 1981, In : Proceedings of the American Association for Cancer Research. Vol. 22, p. C-682

Research output: Contribution to journalArticle

1980

Studies on functional domains of the regulatory subunit of bovine heart adenosine 3':5'-monophosphate-dependent protein kinase.

Flockhart, D. A., Watterson, D. M. & Corbin, J. D., May 25 1980, In : Journal of Biological Chemistry. 255, 10, p. 4435-4440 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Studies on the phosphorylation and dephosphorylation of L-type pyruvate kinase by the catalytic subunit of cyclic AMP-dependent protein kinase

El-Maghrabi, M. R., Haston, W. S., Flockhart, D. A., Claus, T. H. & Pilkis, S. J., Jul 18 1980, In : Journal of Biological Chemistry. 255, 2, p. 668-675 8 p.

Research output: Contribution to journalArticle

64 Scopus citations