Medical & Molecular Genetics

Publications

2019

Nonlinear Z-score modeling for improved detection of cognitive abnormality

ARTFL/LEFFTDS consortium, Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 797-808 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol

Sarkar, D. K., Gangisetty, O., Wozniak, J. R., Eckerle, J. K., Georgieff, M. K., Foroud, T. M., Wetherill, L., Wertelecki, W., Chambers, C. D., Riley, E., Zymak-Zakutnya, N. & Yevtushok, L., Sep 1 2019, In : Alcoholism: Clinical and Experimental Research. 43, 9, p. 1887-1897 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacological management of X-linked hypophosphataemia

Imel, E. A. & White, K. E., Jun 2019, In : British Journal of Clinical Pharmacology. 85, 6, p. 1188-1198 11 p.

Research output: Contribution to journalReview article

4 Scopus citations
1 Scopus citations

Preanalytics and precision pathology: Pathology practices to ensure molecular integrity of cancer patient biospecimens for precision medicine

Compton, C. C., Robb, J. A., Anderson, M. W., Berry, A. B., Birdsong, G. G., Bloom, K. J., Branton, P. A., Crothers, J. W., Cushman-Vokoun, A. M., Hicks, D. G., Khoury, J. D., Laser, J., Marshall, C. B., Misialek, M. J., Natale, K. E., Nowak, J. A., Olson, D., Pfeifer, J. D., Schade, A., Vance, G. H. & 2 others, Walk, E. E. & Yohe, S. L., Jan 1 2019, In : Archives of Pathology and Laboratory Medicine. 143, 11, p. 1346-1363 18 p.

Research output: Contribution to journalReview article

Open Access
8 Scopus citations

Predicting Alzheimer’s disease progression using multi-modal deep learning approach

for Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 1952.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

for the Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 2235.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Preparation and use of a yeast shRNA delivery system for gene silencing in mosquito larvae

Mysore, K., Hapairai, L. K., Wei, N., Realey, J. S., Scheel, N. D., Severson, D. W. & Duman-Scheel, M., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 213-231 19 p. (Methods in Molecular Biology; vol. 1858).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Pretransplant HLA typing revealed loss of heterozygosity in the major histocompatibility complex in a patient with acute myeloid leukemia

Lobashevsky, A. L., Krueger-Sersen, M., Britton, R. M., Littrell, C. A., Singh, S., Cui, C. P., Kashi, Z., Martin, R. K., Breman, A. M., Vance, G. H. & Farag, S. S., Apr 2019, In : Human Immunology. 80, 4, p. 257-262 6 p.

Research output: Contribution to journalArticle

Productive cross-talk with the microenvironment: A critical step in ovarian cancer metastasis

El Aziz, M. A. A., Agarwal, K., Dasari, S. & Mitra, A. K., Oct 2019, In : Cancers. 11, 10, 1608.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Psychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance

Meyers, J. L., Salvatore, J. E., Aliev, F., Johnson, E. C., McCutcheon, V. V., Su, J., Kuo, S. I. C., Lai, D., Wetherill, L., Wang, J. C., Chan, G., Hesselbrock, V., Foroud, T., Bucholz, K. K., Edenberg, H. J., Dick, D. M., Porjesz, B. & Agrawal, A., Dec 1 2019, In : Translational psychiatry. 9, 1, 269.

Research output: Contribution to journalArticle

Open Access

RegSNPs-intron: A computational framework for predicting pathogenic impact of intronic single nucleotide variants

Lin, H., Hargreaves, K. A., Li, R., Reiter, J. L., Wang, Y., Mort, M., Cooper, D. N., Zhou, Y., Zhang, C., Eadon, M. T., Dolan, M. E., Ipe, J., Skaar, T. C. & Liu, Y., Nov 28 2019, In : Genome biology. 20, 1, 254.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Saccharomyces cerevisiae (Baker’s Yeast) as an interfering RNA expression and delivery system

Duman-Scheel, M., Jan 1 2019, In : Current Drug Targets. 20, 9, p. 942-952 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Salmon: Survival analysis learning with multi-omics neural networks on breast cancer

Huang, Z., Zhan, X., Xiang, S., Johnson, T. S., Helm, B., Yu, C. Y., Zhang, J., Salama, P., Rizkalla, M., Han, Z. & Huang, K., Jan 1 2019, In : Frontiers in Genetics. 10, MAR, 166.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

Gunner, G., Cheadle, L., Johnson, K. M., Ayata, P., Badimon, A., Mondo, E., Nagy, M. A., Liu, L., Bemiller, S. M., Kim, K. W., Lira, S. A., Lamb, B. T., Tapper, A. R., Ransohoff, R. M., Greenberg, M. E., Schaefer, A. & Schafer, D. P., Jul 1 2019, In : Nature Neuroscience. 22, 7, p. 1075-1088 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Sesn3 deficiency promotes carcinogen-induced hepatocellular carcinoma via regulation of the hedgehog pathway

Liu, Y., Kim, H. G., Dong, E., Dong, C., Huang, M., Liu, Y., Liangpunsakul, S. & Dong, X. C., Oct 1 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 10, p. 2685-2693 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Sleep disturbance and neurocognitive outcomes in older patients with breast cancer: Interaction with genotype

for the Thinking and Living With Cancer Study, Dec 15 2019, In : Cancer. 125, 24, p. 4516-4524 9 p.

Research output: Contribution to journalArticle

Sustained Klotho delivery reduces serum phosphate in a model of diabetic nephropathy

Hum, J. M., O’Bryan, L. M., Tatiparthi, A. K., Clinkenbeard, E. L., Ni, P., Cramer, M. S., Bhaskaran, M., Johnson, R. L., Wilson, J. M., Smith, R. C. & White, K. E., Jan 17 2019, In : Journal of Applied Physiology. 126, 4, p. 854-862 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Telomere length associations with cognition depend on Alzheimer's disease biomarkers

Alzheimer's Disease Neuroimaging Initiative, 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 883-890 8 p.

Research output: Contribution to journalArticle

Open Access

Telomere Shortening in the Alzheimer's Disease Neuroimaging Initiative Cohort

Nudelman, K. N. H., Lin, J., Lane, K. A., Nho, K., Kim, S., Faber, K. M., Risacher, S. L., Foroud, T. M., Gao, S., Davis, J. W., Weiner, M. W. & Saykin, A. J., Jan 1 2019, In : Journal of Alzheimer's Disease. 71, 1, p. 33-43 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2019, In : Nature communications. 10, 1, 1766.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

The emerging role of epigenetic modifiers in repair of DNA damage associated with chronic inflammatory diseases

Ding, N., Maiuri, A. R. & O'Hagan, H. M., Apr 1 2019, In : Mutation Research - Reviews in Mutation Research. 780, p. 69-81 13 p.

Research output: Contribution to journalReview article

2 Scopus citations

The progression of Wiedemann–Steiner syndrome in adulthood and two novel variants in the KMT2A gene

Feldman, H. R., Dlouhy, S. R., Lah, M. D., Payne, K. K. & Weaver, D. D., Feb 1 2019, In : American Journal of Medical Genetics, Part A. 179, 2, p. 300-305 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

The Role and Therapeutic Potential of miRNAs in Colorectal Liver Metastasis

Sahu, S. S., Dey, S., Nabinger, S. C., Jiang, G., Bates, A., Tanaka, H., Liu, Y. & Kota, J., Dec 1 2019, In : Scientific reports. 9, 1, 15803.

Research output: Contribution to journalArticle

Open Access

The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy

Zhong, X., Pons, M., Poirier, C., Jiang, Y., Liu, J., Sandusky, G. E., Shahda, S., Nakeeb, A., Schmidt, C. M., House, M. G., Ceppa, E. P., Zyromski, N. J., Liu, Y., Jiang, G., Couch, M. E., Koniaris, L. G. & Zimmers, T. A., Oct 1 2019, In : Journal of Cachexia, Sarcopenia and Muscle. 10, 5, p. 1083-1101 19 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The tumor microenvironment of high grade serous ovarian cancer

Stack, M. S., Nephew, K. P., Burdette, J. E. & Mitra, A. K., Jan 1 2019, In : Cancers. 11, 1, 21.

Research output: Contribution to journalEditorial

Open Access
1 Scopus citations

Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers

LEFFTDS Consortium, Nov 2019, In : Neurobiology of Aging. 83, p. 54-62 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Transcriptome profiling reveals matrisome alteration as a key feature of ovarian cancer progression

Mitra, S., Tiwari, K., Podicheti, R., Pandhiri, T., Rusch, D. B., Bonetto, A., Zhang, C. & Mitra, A. K., Oct 2019, In : Cancers. 11, 10, 1513.

Research output: Contribution to journalArticle

Open Access

TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment

Jay, T. R., von Saucken, V. E., Muñoz, B., Codocedo, J. F., Atwood, B. K., Lamb, B. T. & Landreth, G. E., Jan 1 2019, In : Glia. 67, 10, p. 1873-1892 20 p.

Research output: Contribution to journalArticle

4 Scopus citations
Open Access

Type 2 diabetes mellitus, brain atrophy, and cognitive decline

Moran, C., Beare, R., Wang, W., Callisaya, M., Srikanth, V., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Liu, E., Montine, T., Gamst, A., Thomas, R. G. & 234 others, Donohue, M., Walter, S., Gessert, D., Sather, T., Harvey, D., Kornak, J., Dale, A., Bernstein, M., Felmlee, J., Fox, N., Thompson, P., Schuff, N., Alexander, G., Decarli, C., Bandy, D., Koeppe, R. A., Foster, N., Reiman, E. M., Chen, K., Mathis, C., Cairns, N. J., Taylor-Reinwald, L., Trojanowki, J. Q., Shaw, L., Lee, V. M. Y., Korecka, M., Crawford, K., Neu, S., Foroud, T. M., Potkin, S., Shen, L., Kachaturian, Z., Frank, R., Snyder, P. J., Molchan, S., Kaye, J., Quinn, J., Lind, B., Dolen, S., Schneider, L. S., Pawluczyk, S., Spann, B. M., Brewer, J., Vanderswag, H., Heidebrink, J. L., Lord, J. L., Johnson, K., Doody, R. S., Villanueva-Meyer, J., Chowdhury, M., Stern, Y., Honig, L. S., Bell, K. L., Morris, J. C., Ances, B., Carroll, M., Leon, S., Mintun, M. A., Schneider, S., Marson, D., Griffith, R., Clark, D., Grossman, H., Mitsis, E., Romirowsky, A., Detoledo-Morrell, L., Shah, R. C., Duara, R., Varon, D., Roberts, P., Albert, M., Onyike, C., Kielb, S., Rusinek, H., De Leon, M. J., Glodzik, L., De Santi, S., Doraiswamy, P. M., Petrella, J. R., Coleman, R. E., Arnold, S. E., Karlawish, J. H., Wolk, D., Smith, C. D., Jicha, G., Hardy, P., Lopez, O. L., Oakley, M., Simpson, D. M., Porsteinsson, A. P., Goldstein, B. S., Martin, K., Makino, K. M., Ismail, M. S., Brand, C., Mulnard, R. A., Thai, G., McAdams-Ortiz, C., Womack, K., Mathews, D., Quiceno, M., Diaz-Arrastia, R., King, R., Weiner, M., Martin-Cook, K., Devous, M., Levey, A. I., Lah, J. J., Cellar, J. S., Burns, J. M., Anderson, H. S., Swerdlow, R. H., Apostolova, L., Lu, P. H., Bartzokis, G., Silverman, D. H. S., Graff-Radford, N. R., Parfitt, F., Johnson, H., Farlow, M. R., Hake, A. M., Matthews, B. R., Herring, S., Van Dyck, C. H., Carson, R. E., Macavoy, M. G., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Robin Hsiung, G. Y., Feldman, H., Mudge, B., Assaly, M., Kertesz, A., Rogers, J., Trost, D., Bernick, C., Munic, D., Kerwin, D., Mesulam, M. M., Lipowski, K., Wu, C. K., Johnson, N., Sadowsky, C., Martinez, W., Villena, T., Turner, R. S., Johnson, K., Reynolds, B., Sperling, R. A., Johnson, K. A., Marshall, G., Frey, M., Yesavage, J., Taylor, J. L., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M., Belden, C., Jacobson, S., Kowall, N., Killiany, R., Budson, A. E., Norbash, A., Johnson, P. L., Obisesan, T. O., Wolday, S., Bwayo, S. K., Lerner, A., Hudson, L., Ogrocki, P., Fletcher, E., Carmichael, O., Olichney, J., Kittur, S., Borrie, M., Bartha, D. R., Johnson, S., Asthana, S., Carlsson, C. M., Potkin, S. G., Preda, A., Nguyen, D., Tariot, P., Fleisher, A., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D. W., Kataki, M., Zimmerman, E. A., Celmins, D., Brown, A. D., Pearlson, G. D., Blank, K., Anderson, K., Santulli, R. B., Schwartz, E. S., Sink, K. M., Williamson, J. D., Garg, P., Watkins, F., Ott, B. R., Querfurth, H., Tremont, G., Salloway, S., Malloy, P., Correia, S., Rosen, H. J., Miller, B. L., Mintzer, J., Longmire, C. F., Spicer, K., Finger, E., Rachinsky, I., Drost, D., Pomara, N., Hernando, R., Sarrael, A., Schultz, S. K., Boles Ponto, L. L., Shim, H., Smith, K. E., Relkin, N., Chaing, G., Raudin, L., Smith, A., Fargher, K. & Raj, B. A., Feb 19 2019, In : Neurology. 92, 8, p. E823-E830

Research output: Contribution to journalArticle

10 Scopus citations

Using global team science to identify genetic parkinson's disease worldwide

MJFF Global Genetic Parkinson's Disease Study Group, Aug 2019, In : Annals of neurology. 86, 2, p. 153-157 5 p.

Research output: Contribution to journalEditorial

2 Scopus citations
2018

Absence of Replication-Competent Lentivirus in the Clinic: Analysis of Infused T Cell Products

Cornetta, K., Duffy, L., Turtle, C. J., Jensen, M., Forman, S., Binder-Scholl, G., Fry, T., Chew, A., Maloney, D. G. & June, C. H., Jan 3 2018, In : Molecular Therapy. 26, 1, p. 280-288 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework

Schizophrenia and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Jun 25 2018, In : BMC genomics. 19, 1, 494.

Research output: Contribution to journalArticle

3 Scopus citations

Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections

Mlodzianoski, M. J., Cheng-Hathaway, P. J., Bemiller, S. M., McCray, T. J., Liu, S., Miller, D. A., Lamb, B. T., Landreth, G. E. & Huang, F., Aug 1 2018, In : Nature Methods. 15, 8, p. 583-586 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Altered expression of telomere-associated genes in leukocytes among BRCA1 and BRCA2 carriers

Tanaka, H., Phipps, E. A., Wei, T., Wu, X., Goswami, C., Liu, Y., Sledge, G. W., Mina, L. & Herbert, B. S., Apr 2018, In : Molecular Carcinogenesis. 57, 4, p. 567-575 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

A plasma telomeric cell-free DNA level in unaffected women with BRCA1 or/and BRCA2 mutations: A pilot study

Dey, S., Marino, N., Bishop, K., Dahlgren, P. N., Shendre, A., Storniolo, A. M., He, C. & Tanaka, H., Jan 1 2018, In : Oncotarget. 9, 3, p. 4214-4222 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Dec 1 2018, In : Communications Biology. 1, 1, 163.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

A proximal culture method to study paracrine signaling between cells

Dasari, S., Pandhiri, T., Haley, J., Lenz, D. & Mitra, A. K., Aug 28 2018, In : Journal of Visualized Experiments. 2018, 138, e58144.

Research output: Contribution to journalArticle

2 Scopus citations

A system for detecting high impact-low frequency mutations in primary tumors and metastases

Anjanappa, M., Hao, Y., Simpson, E. R., Bhat-Nakshatri, P., Nelson, J. B., Tersey, S. A., Mirmira, R. G., Cohen-Gadol, A. A., Saadatzadeh, M. R., Li, L., Fang, F., Nephew, K. P., Miller, K. D., Liu, Y. & Nakshatri, H., Jan 11 2018, In : Oncogene. 37, 2, p. 185-196 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Attraction and Compaction of Migratory Breast Cancer Cells by Bone Matrix Proteins through Tumor-Osteocyte Interactions

Chen, A., Wang, L., Liu, S., Wang, Y., Liu, Y., Wang, M., Nakshatri, H., Li, B. Y. & Yokota, H., Dec 1 2018, In : Scientific reports. 8, 1, 5420.

Research output: Contribution to journalArticle

4 Scopus citations

Cancer associated fibroblasts: Naughty neighbors that drive ovarian cancer progression

Dasari, S., Fang, Y. & Mitra, A. K., Nov 2018, In : Cancers. 10, 11, 406.

Research output: Contribution to journalReview article

17 Scopus citations

Cancer-related cognitive outcomes among older breast cancer survivors in the thinking and living with cancer study

Mandelblatt, J. S., Small, B. J., Luta, G., Hurria, A., Jim, H., McDonald, B. C., Graham, D., Zhou, X., Clapp, J., Zhai, W., Breen, E., Carroll, J. E., Denduluri, N., Dilawari, A., Extermann, M., Isaacs, C., Jacobsen, P. B., Kobayashi, L. C., Holohan Nudelman, K., Root, J. & 6 others, Stern, R. A., Tometich, D., Turner, R., VanMeter, J. W., Saykin, A. J. & Ahles, T., Nov 10 2018, In : Journal of Clinical Oncology. 36, 32, p. 3211-3222 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Cellular players that shape evolving pathology and neurodegeneration following traumatic brain injury

Puntambekar, S. S., Saber, M., Lamb, B. T. & Kokiko-Cochran, O. N., Jul 2018, In : Brain, Behavior, and Immunity. 71, p. 9-17 9 p.

Research output: Contribution to journalReview article

8 Scopus citations

Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

for the Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2018, In : Scientific reports. 8, 1, 13807.

Research output: Contribution to journalArticle

4 Scopus citations

Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1

Hankey, W., Chen, Z., Bergman, M. J., Fernandez, M. O., Hancioglu, B., Lan, X., Jegga, A. G., Zhang, J., Jin, V. X., Aronow, B. J., Wang, Q. & Groden, J., Jul 27 2018, In : Oncotarget. 9, 58, p. 31214-31230 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Collagen COL22A1 maintains vascular stability and mutations in COL22A1 are potentially associated with intracranial aneurysms

Ton, Q. V., Leino, D., Mowery, S. A., Bredemeier, N. O., Lafontant, P. J., Lubert, A., Gurung, S., Farlow, J. L., Foroud, T., Broderick, J. & Sumanas, S., Dec 12 2018, In : Disease models & mechanisms. 11, 12

Research output: Contribution to journalArticle

4 Scopus citations

Combined Face–Brain Morphology and Associated Neurocognitive Correlates in Fetal Alcohol Spectrum Disorders

the CIFASD, Sep 2018, In : Alcoholism: Clinical and Experimental Research. 42, 9, p. 1769-1782 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Combined neuropathological pathways account for age-related risk of dementia

Power, M. C., Mormino, E., Soldan, A., James, B. D., Yu, L., Armstrong, N. M., Bangen, K. J., Delano-Wood, L., Lamar, M., Lim, Y. Y., Nudelman, K., Zahodne, L., Gross, A. L., Mungas, D., Widaman, K. F. & Schneider, J., Jul 2018, In : Annals of neurology. 84, 1, p. 10-22 13 p.

Research output: Contribution to journalArticle

19 Scopus citations