Pharmacology & Toxicology

Publications 1971 2019

2019

A novel GCN5b lysine acetyltransferase complex associates with distinct transcription factors in the protozoan parasite Toxoplasma gondii

Harris, M. T., Jeffers, V., Martynowicz, J., True, J. D., Mosley, A. & Sullivan, W., Sep 1 2019, In : Molecular and Biochemical Parasitology. 232, 111203.

Research output: Contribution to journalArticle

Toxoplasma
Acetylation
Epigenomics
Proteomics
Parasites

A plasma membrane localized protein phosphatase in Toxoplasma gondii, PPM5C, regulates attachment to host cells

Yang, C., Broncel, M., Dominicus, C., Sampson, E., Blakely, W. J., Treeck, M. & Arrizabalaga, G., Dec 1 2019, In : Scientific Reports. 9, 1, 5924.

Research output: Contribution to journalArticle

Open Access
Phosphoprotein Phosphatases
Toxoplasma
Blood Proteins
Membrane Proteins
Parasites

Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells

VanderWall, K. B., Vij, R., Ohlemacher, S. K., Sridhar, A., Fligor, C. M., Feder, E. M., Edler, M. C., Baucum, A. J., Cummins, T. & Meyer, J. S., Feb 12 2019, In : Stem Cell Reports. 12, 2, p. 201-212 12 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Retinal Ganglion Cells
Stem cells
Astrocytes
Brain

Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii

Liu, M., Li, F. X., Li, C. Y., Li, X. C., Chen, L. F., Wu, K., Yang, P. L., Lai, Z. F., Liu, T. K., Sullivan, W., Cui, L. & Chen, X. G., May 8 2019, In : Parasites and Vectors. 12, 1, 221.

Research output: Contribution to journalArticle

Open Access
Protein-Arginine N-Methyltransferases
Toxoplasma
Methylation
Hemagglutinins
Post Translational Protein Processing

Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection

Shah, K., Queener, S., Cody, V., Pace, J. & Gangjee, A., Aug 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 15, p. 1874-1880 7 p.

Research output: Contribution to journalArticle

Pneumocystis Infections
Folic Acid Antagonists
Pneumocystis Pneumonia
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase

Energy Metabolism and Mitochondrial Superoxide Anion Production in Pre-symptomatic Striatal Neurons Derived from Human-Induced Pluripotent Stem Cells Expressing Mutant Huntingtin

Hamilton, J., Brustovetsky, T., Sridhar, A., Pan, Y., Cummins, T., Meyer, J. S. & Broustovetski, N., Jan 1 2019, (Accepted/In press) In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Corpus Striatum
Induced Pluripotent Stem Cells
Superoxides
Energy Metabolism
Neurons
2 Citations (Scopus)

Evaluation of ATM Kinase Inhibitor KU-55933 as Potential Anti-Toxoplasma gondii Agent

Munera López, J., Ganuza, A., Bogado, S. S., Muñoz, D., Ruiz, D. M., Sullivan, W., Vanagas, L. & Angel, S. O., Jan 1 2019, In : Frontiers in cellular and infection microbiology. 9, 1 p.

Research output: Contribution to journalArticle

Open Access
Toxoplasma
Phosphotransferases
Parasites
Phosphatidylinositol 3-Kinase
Camptothecin

Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons

Wu, B., McDermott, J. S., Krajewski, J. L., Knopp, K. L., Nisenbaum, E. S., Cummins, T. & Tan, Z. Y., Mar 1 2019, In : Molecular Pain. 15

Research output: Contribution to journalArticle

Open Access
Extracellular Signal-Regulated MAP Kinases
Spinal Ganglia
Neurons
Tetrodotoxin
Protein Kinase C

Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding

Reilly, A. M., Zhou, S., Panigrahi, S. K., Yan, S., Conley, J. M., Sheets, P. L., Wardlaw, S. L. & Ren, H., Dec 1 2019, In : Nutrition and Diabetes. 9, 1, 29.

Research output: Contribution to journalArticle

Open Access
Pro-Opiomelanocortin
High Fat Diet
Neurons
Knockout Mice
Homeostasis

Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation

Martynowicz, J., Augusto, L., Wek, R., Boehm, S. L. & Sullivan, W., Apr 30 2019, In : mBio. 10, 2

Research output: Contribution to journalArticle

Open Access
Guanabenz
Toxoplasmosis
Cysts
Parasites
Toxoplasma

Hedgehog pathway activation alters ciliary signaling in primary hypothalamic cultures

Bansal, R., Engle, S. E., Antonellis, P. J., Whitehouse, L. S., Baucum, A. J., Cummins, T., Reiter, J. F. & Berbari, N. F., May 14 2019, In : Frontiers in Cellular Neuroscience. 13, 266.

Research output: Contribution to journalArticle

Open Access
Hedgehogs
Cilia
Neurons
Hyperphagia
Feeding Behavior
1 Citation (Scopus)

Increased Resurgent Sodium Currents in Nav1.8 Contribute to Nociceptive Sensory Neuron Hyperexcitability Associated with Peripheral Neuropathies

Xiao, Y., Barbosa, C., Pei, Z., Xie, W., Strong, J. A., Zhang, J. M. & Cummins, T., Feb 20 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 8, p. 1539-1550 12 p.

Research output: Contribution to journalArticle

Nociceptors
Peripheral Nervous System Diseases
Sensory Receptor Cells
Sodium
Diagnosis-Related Groups

Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality

Shao, Y., Wichern, E., Childress, P. J., Adaway, M., Misra, J., Klunk, A., Burr, D., Wek, R., Mosley, A., Liu, Y., Robling, A., Broustovetski, N., Hamilton, J., Jacobs, K., Vashishth, D., Stayrook, K. R., Allen, M., Wallace, J. M. & Bidwell, J., May 1 2019, In : American journal of physiology. Endocrinology and metabolism. 316, 5, p. E749-E772

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Bone and Bones
Osteoblasts
Osteogenesis
Osteoporosis
Open Access
Toxoplasma
Protein Transport
Phosphotransferases
Vacuoles
Proteins
Methamphetamine
Dopaminergic Neurons
Alcohols
Drinking
Dopamine Plasma Membrane Transport Proteins
Eukaryotic Initiation Factors
Entamoeba histolytica
Endoplasmic Reticulum Stress
Parasites
Phosphorylation

PRMTs and miRNAs: functional cooperation in cancer and beyond

Jin, J., Martin, M., Hartley, A. V. & Lu, T., Aug 3 2019, In : Cell Cycle. 18, 15, p. 1676-1686 11 p.

Research output: Contribution to journalReview article

Protein-Arginine N-Methyltransferases
MicroRNAs
Epigenomics
Neoplasms
Gene Expression

Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii

Augusto, L., Amin, P. H., Wek, R. & Sullivan, W., Jun 1 2019, In : PLoS pathogens. 15, 6, p. e1007746

Research output: Contribution to journalArticle

Open Access
Toxoplasma
Arginine
Parasites
Phosphotransferases
Food

Resurgent and Gating Pore Currents Induced by De Novo SCN2A Epilepsy Mutations

Mason, E. R., Wu, F., Patel, R. R., Xiao, Y., Cannon, S. C. & Cummins, T. R., Sep 1 2019, In : eNeuro. 6, 5

Research output: Contribution to journalArticle

Open Access
Epilepsy
Mutation
Electrophysiology
Xenopus
Point Mutation

Simultaneous ribosome profiling of human host cells infected with Toxoplasma gondii

Holmes, M. J., Shah, P., Wek, R. & Sullivan, W., May 1 2019, In : mSphere. 4, 3, e00292-19.

Research output: Contribution to journalArticle

Open Access
Toxoplasma
Ribosomes
Parasites
Gene Expression
Foreskin

Stat3 in osteocytes mediates osteogenic response to loading

Corry, K. A., Zhou, H., Brustovetsky, T., Himes, E. R., Bivi, N., Horn, M. R., Kitase, Y., Wallace, J. M., Bellido, T., Broustovetski, N. & Li, J., Dec 1 2019, In : Bone Reports. 11, 100218.

Research output: Contribution to journalArticle

Open Access
Osteocytes
STAT3 Transcription Factor
Osteoclasts
Osteoblasts
Osteogenesis

The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1

Luo, Q., Xiao, Y., Alex, A., Cummins, T. & Bhatwadekar, A., May 1 2019, In : Investigative ophthalmology & visual science. 60, 6, p. 1928-1936 9 p.

Research output: Contribution to journalArticle

Open Access
Insulin Receptor Substrate Proteins
Circadian Rhythm
Genes
Insulin
Patch-Clamp Techniques
2018
1 Citation (Scopus)

A Dose-escalation Study of Recombinant Human Interleukin-18 in Combination with Ofatumumab after Autologous Peripheral Blood Stem Cell Transplantation for Lymphoma

Robertson, M., Stamatkin, C. W., Pelloso, D., Weisenbach, J., Prasad, N. K. & Safa, A., Jan 1 2018, In : Journal of Immunotherapy. 41, 3, p. 151-157 7 p.

Research output: Contribution to journalArticle

Peripheral Blood Stem Cell Transplantation
Interleukin-18
Lymphoma
Intravenous Infusions
Natural Killer Cells
2 Citations (Scopus)

Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells

Thompson, K., Chen, J., Luo, Q., Xiao, Y., Cummins, T. & Bhatwadekar, A., Feb 1 2018, In : PLoS One. 13, 2, e0193280.

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
laminin
Laminin
glycation
Down-Regulation
12 Citations (Scopus)

A latent ability to persist: differentiation in Toxoplasma gondii

Jeffers, V., Tampaki, Z., Kim, K. & Sullivan, W., Mar 30 2018, (Accepted/In press) In : Cellular and Molecular Life Sciences. p. 1-19 19 p.

Research output: Contribution to journalArticle

Toxoplasma
Acute Disease
Vacuoles
Vertebrates
Cysts
11 Citations (Scopus)

Altered excitability and local connectivity of mPFC-PAG neurons in a mouse model of neuropathic pain

Cheriyan, J. & Sheets, P., May 16 2018, In : Journal of Neuroscience. 38, 20, p. 4829-4839 11 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Neuralgia
Prefrontal Cortex
Constriction
Neurons
2 Citations (Scopus)

A minimalistic approach to develop new anti-apicomplexa polyamines analogs

Panozzo-Zénere, E. A., Porta, E. O. J., Arrizabalaga, G., Fargnoli, L., Khan, S. I., Tekwani, B. L. & Labadie, G. R., Jan 1 2018, In : European Journal of Medicinal Chemistry. 143, p. 866-880 15 p.

Research output: Contribution to journalArticle

Apicomplexa
Diamines
Polyamines
Parasites
Toxoplasma
3 Citations (Scopus)

APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells

McIlwain, D. W., Fishel, M., Boos, A., Kelley, M. & Jerde, T., Jan 1 2018, In : Oncotarget. 9, 13, p. 10962-10977 16 p.

Research output: Contribution to journalArticle

Endonucleases
Cell Cycle Checkpoints
Oxidation-Reduction
Prostatic Neoplasms
Proteins

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

Rush, A. M., Dib-Hajj, S. D., Liu, S., Cummins, T., Black, J. A. & Waxman, S. G., Jan 1 2018, Chasing Men on Fire: The Story of the Search for a Pain Gene. The MIT Press, p. 89-101 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sodium Channels
Neurons
Mutation
2 Citations (Scopus)

Calcium/calmodulin-dependent protein kinase II regulation of IKs during sustained β-adrenergic receptor stimulation

Shugg, T., Johnson, D. E., Shao, M., Lai, X., Witzmann, F., Cummins, T., Rubart-von der Lohe, M., Hudmon, A. & Overholser, B. R., Jun 1 2018, In : Heart Rhythm. 15, 6, p. 895-904 10 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Adrenergic Receptors
Isoproterenol
Phosphorylation

Cerebrovascular Injury after Serial Exposure to Chronic Stress and Abstinence from Methamphetamine Self-Administration

Natarajan, R., Mitchell, C. M., Harless, N. & Yamamoto, B., Dec 1 2018, In : Scientific Reports. 8, 1, 10558.

Research output: Contribution to journalArticle

Self Administration
Methamphetamine
Wounds and Injuries
Occludin
Cyclooxygenase 2
3 Citations (Scopus)

Characterization of Membrane Patch-Ion Channel Probes for Scanning Ion Conductance Microscopy

Shi, W., Zeng, Y., Zhu, C., Xiao, Y., Cummins, T., Hou, J. & Baker, L. A., May 3 2018, In : Small. 14, 18, 1702945.

Research output: Contribution to journalArticle

Ion Channels
Microscopy
Microscopic examination
Ions
Membranes
3 Citations (Scopus)
Plasmodium
Toxoplasma
Plasmodium falciparum
Parasites
Malaria
1 Citation (Scopus)

Cholesterol esterification inhibition and gemcitabine synergistically suppress pancreatic ductal adenocarcinoma proliferation

Li, J., Qu, X., Tian, J., Zhang, J-T. & Cheng, J. X., Feb 1 2018, In : PLoS One. 13, 2, e0193318.

Research output: Contribution to journalArticle

gemcitabine
Esterification
esterification
adenocarcinoma
Adenocarcinoma

Correction: Effective targeting of the survivin dimerization interface with small-molecule inhibitors (Cancer Research (2016)76 (453-462) DOI: 10.1158/0008-5472.CAN-15-1874)

Qi, J., Dong, Z., Liu, J., Peery, R. C., Zhang, S., Liu, J. Y. & Zhang, J. T., Dec 15 2018, In : Cancer Research. 78, 24, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Dimerization
Western Blotting
Research
Neoplasms
Emotions
1 Citation (Scopus)

Deletion of mitochondrial calcium uniporter incompletely inhibits calcium uptake and induction of the permeability transition pore in brain mitochondria

Hamilton, J., Brustovetsky, T., Rysted, J. E., Lin, Z., Usachev, Y. M. & Broustovetski, N., Jan 1 2018, In : Journal of Biological Chemistry. 293, 40, p. 15652-15663 12 p.

Research output: Contribution to journalArticle

Mitochondria
Permeability
Brain
Calcium
mitochondrial calcium uniporter
1 Citation (Scopus)

Effects of PERK eIF2α Kinase Inhibitor against Toxoplasma gondii

Augusto, L., Martynowicz, J., Staschke, K. A., Wek, R. & Sullivan, W., Nov 1 2018, In : Antimicrobial Agents and Chemotherapy. 62, 11

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Toxoplasma
Parasites
Phosphotransferases
Endoplasmic Reticulum Stress
5 Citations (Scopus)

eIF3a: A new anticancer drug target in the eIF family

Yin, J. Y., Zhang, J-T., Zhang, W., Zhou, H. H. & Liu, Z. Q., Jan 1 2018, In : Cancer Letters. 412, p. 81-87 7 p.

Research output: Contribution to journalShort survey

Physiological Phenomena
Proto-Oncogenes
Pathologic Processes
Pharmaceutical Preparations
Neoplasms

Electrophysiological properties of mutant NaV1.7 sodium channels in a painful inherited neuropathy

Cummins, T., Dib-Hajj, S. D. & Waxman, S. G., Jan 1 2018, Chasing Men on Fire: The Story of the Search for a Pain Gene. The MIT Press, p. 35-43 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sodium Channels
Painful Neuropathy
1 Citation (Scopus)

Elp3 and RlmN: A tale of two mitochondrial tail-anchored radical SAM enzymes in Toxoplasma gondii

Padgett, L. R., Lentini, J. M., Holmes, M. J., Stilger, K. L., Fu, D. & Sullivan, W., Jan 1 2018, In : PLoS One. 13, 1, e0189688.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Toxoplasma
Toxoplasma gondii
S-adenosylmethionine
Tail

Gain-of-function mutation in NaV1.7 in familial erythromelalgia induces bursting of sensory neurons

Dib-Hajj, S. D., Rush, A. M., Cummins, T., Hisama, F. M., Novella, S., Tyrrell, L., Marshall, L. & Waxman, S. G., Jan 1 2018, Chasing Men on Fire: The Story of the Search for a Pain Gene. The MIT Press, p. 44-55 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Erythromelalgia
Sensory Receptor Cells
Mutation
7 Citations (Scopus)

Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain

François-Moutal, L., Dustrude, E. T., Wang, Y., Brustovetsky, T., Dorame, A., Ju, W., Moutal, A., Perez-Miller, S., Broustovetski, N., Gokhale, V., Khanna, M. & Khanna, R., Oct 1 2018, In : Pain. 159, 10, p. 2115-2127 13 p.

Research output: Contribution to journalArticle

Sumoylation
Neuralgia
Ubiquitin
Enzymes
Peptides

Interactions of peripheral endothelin-1 and nerve growth factor as contributors to persistent Cutaneous Pain

Khodorova, A., Zhang, Y., Nicol, G. & Strichartz, G., Jan 1 2018, In : Physiological Research. 67, p. S215-S225

Research output: Contribution to journalArticle

Endothelin-1
Nerve Growth Factor
Pain
Skin
Touch
3 Citations (Scopus)

Mechanisms regulating the association of protein phosphatase 1 with spinophilin and neurabin.

Edler, M. C., Salek, A. B., Watkins, D. S., Kaur, H., Morris, C. W., Yamamoto, B. & Baucum, A. J., Mar 28 2018, (Accepted/In press) In : ACS Chemical Neuroscience.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Association reactions
Methamphetamine
Dopamine
Phosphorylation

NF-κB: Its role in colorectal cancer

Hartley, A., Wei, H., Prabhu, L., Martin, M. & Lu, T., Jan 1 2018, Role of Transcription Factors in Gastrointestinal Malignancies. Springer Singapore, p. 247-260 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tumors
Colorectal Neoplasms
Genes
Cells
Cell proliferation
3 Citations (Scopus)

Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth

Li, X., Ma, H., Li, L., Chen, Y., Sun, X., Dong, Z., Liu, J. Y., Zhu, W. & Zhang, J-T., May 1 2018, In : Oncogene. 37, 18, p. 2469-2480 12 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
src Homology Domains
Alkaloids
Heterografts
Transcriptional Activation
2 Citations (Scopus)

Peripheral Synthesis of an Atypical Protein Kinase C Mediates the Enhancement of Excitability and the Development of Mechanical Hyperalgesia Produced by Nerve Growth Factor

Kays, J., Zhang, Y. H., Khorodova, A., Strichartz, G. & Nicol, G., Feb 10 2018, In : Neuroscience. 371, p. 420-432 13 p.

Research output: Contribution to journalArticle

Hyperalgesia
Nerve Growth Factor
PKC-3 protein
Injections
Long-Term Potentiation

Posttranslational modification of sodium channels

Pei, Z., Pan, Y. & Cummins, T., Jan 1 2018, Handbook of Experimental Pharmacology. Springer New York LLC, p. 101-124 24 p. (Handbook of Experimental Pharmacology; vol. 246).

Research output: Chapter in Book/Report/Conference proceedingChapter

Voltage-Gated Sodium Channels
Sodium Channels
Post Translational Protein Processing
Protein Isoforms
Lipoylation
4 Citations (Scopus)

Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis

Huang, W., Liu, Y., Wang, J., Yuan, X., Jin, H. W., Zhang, L. R., Zhang, J-T., Liu, Z. M. & Cui, J. R., Sep 5 2018, In : European Journal of Medicinal Chemistry. 157, p. 887-897 11 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Ovarian Neoplasms
Cisplatin
Cells
Apoptosis
3 Citations (Scopus)
Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Opportunistic Infections
Amino Acids