Pharmacology & Toxicology

Publications

2020

Assessment, Quantification, and Management of Fracture Pain: from Animals to the Clinic

McVeigh, L. G., Perugini, A. J., Fehrenbacher, J. C., White, F. A. & Kacena, M. A., 2020, (Accepted/In press) In : Current osteoporosis reports.

Research output: Contribution to journalReview article

CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability

Zybura, A. S., Baucum, A. J., Rush, A. M., Cummins, T. R. & Hudmon, A., Aug 14 2020, In : The Journal of biological chemistry. 295, 33, p. 11845-11865 21 p.

Research output: Contribution to journalArticle

Open Access

Differential inhibition of human Nav1.2 resurgent and persistent sodium currents by cannabidiol and GS967

Mason, E. R. & Cummins, T. R., Apr 1 2020, In : International journal of molecular sciences. 21, 7, p. 1-21 21 p., 2454.

Research output: Contribution to journalArticle

Open Access

Distinct functional alterations in SCN8A epilepsy mutant channels

Pan, Y. & Cummins, T. R., Jan 1 2020, In : Journal of Physiology. 598, 2, p. 381-401 21 p.

Research output: Contribution to journalArticle

4 Scopus citations

Efficacy of guanabenz combination therapy against chronic toxoplasmosis across multiple mouse strains

Martynowicz, J., Stone Doggett, J. & Sullivan, W. J., Sep 2020, In : Antimicrobial Agents and Chemotherapy. 64, 9, e00535-20.

Research output: Contribution to journalArticle

Emerging Therapeutic Targets Against Toxoplasma gondii: Update on DNA Repair Response Inhibitors and Genotoxic Drugs

Angel, S. O., Vanagas, L., Ruiz, D. M., Cristaldi, C., Saldarriaga Cartagena, A. M. & Sullivan, W. J., Jun 12 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 289.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Evaluating the GCN5b bromodomain as a novel therapeutic target against the parasite Toxoplasma gondii

Hanquier, J., Gimeno, T., Jeffers, V. & Sullivan, W. J., Apr 2020, In : Experimental Parasitology. 211, 107868.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of fis1 interactors in Toxoplasma gondii reveals a novel protein required for peripheral distribution of the mitochondrion

Jacobs, K., Charvat, R. & Arrizabalaga, G., Jan 1 2020, In : mBio. 11, 1, e02732-19.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Mastering Toxoplasma sex and sleep

Sullivan, W. J., Apr 1 2020, In : Nature Microbiology. 5, 4, p. 533-534 2 p.

Research output: Contribution to journalArticle

Modulating the modulators: regulation of protein arginine methyltransferases by post-translational modifications

Hartley, A. V. & Lu, T., 2020, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalReview article

Open Access

No pain, no gain? The effects of pain-promoting neuropeptides and neurotrophins on fracture healing

Sun, S., Diggins, N. H., Gunderson, Z. J., Fehrenbacher, J. C., White, F. A. & Kacena, M. A., Feb 2020, In : Bone. 131, 115109.

Research output: Contribution to journalReview article

4 Scopus citations
Open Access

Regulation of a PRMT5/NF-κB axis by phosphorylation of PRMT5 at serine 15 in colorectal cancer

Hartley, A. V., Wang, B., Jiang, G., Wei, H., Sun, M., Prabhu, L., Martin, M., Safa, A., Sun, S., Liu, Y. & Lu, T., May 2 2020, In : International journal of molecular sciences. 21, 10, 3684.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids

VanderWall, K. B., Huang, K. C., Pan, Y., Lavekar, S. S., Fligor, C. M., Allsop, A. R., Lentsch, K. A., Dang, P., Zhang, C., Tseng, H. C., Cummins, T. R. & Meyer, J. S., Jul 14 2020, In : Stem Cell Reports. 15, 1, p. 52-66 15 p.

Research output: Contribution to journalArticle

Open Access

Sex-Specific Disruption of Distinct mPFC Inhibitory Neurons in Spared-Nerve Injury Model of Neuropathic Pain

Jones, A. F. & Sheets, P. L., Jun 9 2020, In : Cell Reports. 31, 10, 107729.

Research output: Contribution to journalArticle

Open Access

S-Palmitoylation of the sodium channel Nav1.6 regulates its activity and neuronal excitability

Pan, Y., Xiao, Y., Pei, Z. & Cummins, T. R., May 1 2020, In : Journal of Biological Chemistry. 295, 18, p. 6151-6164 14 p.

Research output: Contribution to journalArticle

Open Access
Open Access
2 Scopus citations

The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS

Jara, J. H., Sheets, P. L., Nigro, M. J., Perić, M., Brooks, C., Heller, D. B., Martina, M., Andjus, P. R. & Ozdinler, P. H., May 19 2020, In : Frontiers in Molecular Neuroscience. 13, 73.

Research output: Contribution to journalArticle

Open Access

The secreted acid phosphatase domain-containing GRA44 from Toxoplasma gondii is required for c-Myc induction in infected cells

Blakely, W. J., Holmes, M. J. & Arrizabalaga, G., Jan 1 2020, In : mSphere. 5, 1, e00877.

Research output: Contribution to journalArticle

1 Scopus citations

Toxoplasma gondii co-opts the unfolded protein response to enhance migration and dissemination of infected host cells

Augusto, L., Martynowicz, J., Amin, P. H., Alakhras, N. S., Kaplan, M. H., Wek, R. C. & Sullivan, W. J., Aug 2020, In : mBio. 11, 4, p. 1-13 13 p., e00915-20.

Research output: Contribution to journalArticle

Open Access
2019

A novel GCN5b lysine acetyltransferase complex associates with distinct transcription factors in the protozoan parasite Toxoplasma gondii

Harris, M. T., Jeffers, V., Martynowicz, J., True, J. D., Mosley, A. L. & Sullivan, W. J., Sep 2019, In : Molecular and Biochemical Parasitology. 232, 111203.

Research output: Contribution to journalArticle

2 Scopus citations

Antitumor activity and mechanistic characterization of APE1/ReF-1 inhibitors in bladder cancer

Fishel, M. L., Xia, H., McGeown, J., McIlwain, D. W., Elbanna, M., Craft, A. A., Kaimakliotis, H. Z., Sandusky, G. E., Zhang, C., Pili, R., Kelley, M. R. & Jerde, T. J., 2019, In : Molecular cancer therapeutics. 18, 11, p. 1947-1960 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

A plasma membrane localized protein phosphatase in Toxoplasma gondii, PPM5C, regulates attachment to host cells

Yang, C., Broncel, M., Dominicus, C., Sampson, E., Blakely, W. J., Treeck, M. & Arrizabalaga, G., Dec 1 2019, In : Scientific reports. 9, 1, 5924.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells

VanderWall, K. B., Vij, R., Ohlemacher, S. K., Sridhar, A., Fligor, C. M., Feder, E. M., Edler, M. C., Baucum, A. J., Cummins, T. R. & Meyer, J. S., Feb 12 2019, In : Stem Cell Reports. 12, 2, p. 201-212 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2 Scopus citations

Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii

Liu, M., Li, F. X., Li, C. Y., Li, X. C., Chen, L. F., Wu, K., Yang, P. L., Lai, Z. F., Liu, T. K., Sullivan, W. J., Cui, L. & Chen, X. G., May 8 2019, In : Parasites and Vectors. 12, 1, 221.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection

Shah, K., Queener, S., Cody, V., Pace, J. & Gangjee, A., Aug 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 15, p. 1874-1880 7 p.

Research output: Contribution to journalArticle

Evaluation of ATM Kinase Inhibitor KU-55933 as Potential Anti-Toxoplasma gondii Agent

Munera López, J., Ganuza, A., Bogado, S. S., Muñoz, D., Ruiz, D. M., Sullivan, W. J., Vanagas, L. & Angel, S. O., Jan 1 2019, In : Frontiers in Cellular and Infection Microbiology. 9, 1 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
Open Access

Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons

Wu, B., McDermott, J. S., Krajewski, J. L., Knopp, K. L., Nisenbaum, E. S., Cummins, T. R. & Tan, Z. Y., Mar 1 2019, In : Molecular Pain. 15

Research output: Contribution to journalArticle

Open Access

Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding

Reilly, A. M., Zhou, S., Panigrahi, S. K., Yan, S., Conley, J. M., Sheets, P. L., Wardlaw, S. L. & Ren, H., Dec 1 2019, In : Nutrition and Diabetes. 9, 1, 29.

Research output: Contribution to journalArticle

Open Access

Guanabenz reverses a key behavioral change caused by latent toxoplasmosis in mice by reducing neuroinflammation

Martynowicz, J., Augusto, L., Wek, R. C., Boehm, S. L. & Sullivan, W. J., Mar 1 2019, In : mBio. 10, 2, e00381-19.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Hedgehog pathway activation alters ciliary signaling in primary hypothalamic cultures

Bansal, R., Engle, S. E., Antonellis, P. J., Whitehouse, L. S., Baucum, A. J., Cummins, T. R., Reiter, J. F. & Berbari, N. F., May 14 2019, In : Frontiers in Cellular Neuroscience. 13, 266.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Increased resurgent sodium currents in nav1.8 contribute to nociceptive sensory neuron hyperexcitability associated with peripheral neuropathies

Xiao, Y., Barbosa, C., Pei, Z., Xie, W., Strong, J. A., Zhang, J. M. & Cummins, T. R., Feb 20 2019, In : Journal of Neuroscience. 39, 8, p. 1539-1550 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality

Shao, Y., Wichern, E., Childress, P. J., Adaway, M., Misra, J., Klunk, A., Burr, D. B., Wek, R. C., Mosley, A. L., Liu, Y., Robling, A. G., Brustovetsky, N., Hamilton, J., Jacobs, K., Vashishth, D., Stayrook, K. R., Allen, M. R., Wallace, J. M. & Bidwell, J. P., May 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 316, 5, p. E749-E772

Research output: Contribution to journalArticle

2 Scopus citations

Mutant huntingtin fails to directly impair brain mitochondria

Hamilton, J., Brustovetsky, T. & Brustovetsky, N., Dec 1 2019, In : Journal of Neurochemistry. 151, 6, p. 716-731 16 p.

Research output: Contribution to journalArticle

Open Access

Neurotoxicity to dopamine neurons after the serial exposure to alcohol and methamphetamine: Protection by COX-2 antagonism

Blaker, A. L., Rodriguez, E. A. & Yamamoto, B. K., Oct 2019, In : Brain, Behavior, and Immunity. 81, p. 317-328 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

PRMTs and miRNAs: functional cooperation in cancer and beyond

Jin, J., Martin, M., Hartley, A. V. & Lu, T., Aug 3 2019, In : Cell Cycle. 18, 15, p. 1676-1686 11 p.

Research output: Contribution to journalReview article

2 Scopus citations

Regulation of arginine transport by GCN2 eiF2 kinase is important for replication of the intracellular parasite toxoplasma gondii

Augusto, L., Amin, P. H., Wek, R. C. & Sullivan, W. J., Jun 2019, In : PLoS pathogens. 15, 6, e1007746.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Repositioning of Guanabenz in Conjugation with Gold and Silver Nanoparticles against Pathogenic Amoebae Acanthamoeba castellanii and Naegleria fowleri

Anwar, A., Mungroo, M. R., Anwar, A., Sullivan, W. J., Khan, N. A. & Siddiqui, R., Dec 13 2019, In : ACS Infectious Diseases. 5, 12, p. 2039-2046 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Serial exposure to ethanol drinking and methamphetamine enhances glutamate excitotoxicity

Blaker, A. L., Moore, E. R. & Yamamoto, B. K., Dec 1 2019, In : Journal of Neurochemistry. 151, 6, p. 749-763 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Simultaneous ribosome profiling of human host cells infected with Toxoplasma gondii

Holmes, M. J., Shah, P., Wek, R. C. & Sullivan, W. J., May 1 2019, In : mSphere. 4, 3, e00292-19.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Stat3 in osteocytes mediates osteogenic response to loading

Corry, K. A., Zhou, H., Brustovetsky, T., Himes, E. R., Bivi, N., Horn, M. R., Kitase, Y., Wallace, J. M., Bellido, T., Brustovetsky, N. & Li, J., Dec 2019, In : Bone Reports. 11, 100218.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

TgDrpC, an atypical dynamin-related protein in Toxoplasma gondii, is associated with vesicular transport factors and parasite division

Heredero-Bermejo, I., Varberg, J. M., Charvat, R., Jacobs, K., Garbuz, T., Sullivan, W. J. & Arrizabalaga, G., Jan 2019, In : Molecular Microbiology. 111, 1, p. 46-64 19 p.

Research output: Contribution to journalArticle

7 Scopus citations
Open Access
2 Scopus citations
2018

Absorption, Enterohepatic Circulation, and Fecal Excretion of Toxicants

Watkins, J. B. & Klaassen, C. D., Jan 1 2018, Gastrointestinal Toxicology. Elsevier Inc., Vol. 3-15. p. 99-112 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

A Dose-escalation Study of Recombinant Human Interleukin-18 in Combination with Ofatumumab after Autologous Peripheral Blood Stem Cell Transplantation for Lymphoma

Robertson, M. J., Stamatkin, C. W., Pelloso, D., Weisenbach, J., Prasad, N. K. & Safa, A. R., Jan 1 2018, In : Journal of Immunotherapy. 41, 3, p. 151-157 7 p.

Research output: Contribution to journalArticle

1 Scopus citations