Pharmacology & Toxicology

Publications 1971 2019

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2018

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

Rush, A. M., Dib-Hajj, S. D., Liu, S., Cummins, T., Black, J. A. & Waxman, S. G., Jan 1 2018, Chasing Men on Fire: The Story of the Search for a Pain Gene. The MIT Press, p. 89-101 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sodium Channels
Neurons
Mutation

Electrophysiological properties of mutant NaV1.7 sodium channels in a painful inherited neuropathy

Cummins, T., Dib-Hajj, S. D. & Waxman, S. G., Jan 1 2018, Chasing Men on Fire: The Story of the Search for a Pain Gene. The MIT Press, p. 35-43 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sodium Channels
Painful Neuropathy

Gain-of-function mutation in NaV1.7 in familial erythromelalgia induces bursting of sensory neurons

Dib-Hajj, S. D., Rush, A. M., Cummins, T., Hisama, F. M., Novella, S., Tyrrell, L., Marshall, L. & Waxman, S. G., Jan 1 2018, Chasing Men on Fire: The Story of the Search for a Pain Gene. The MIT Press, p. 44-55 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Erythromelalgia
Sensory Receptor Cells
Mutation

NF-κB: Its role in colorectal cancer

Hartley, A., Wei, H., Prabhu, L., Martin, M. & Lu, T., Jan 1 2018, Role of Transcription Factors in Gastrointestinal Malignancies. Springer Singapore, p. 247-260 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tumors
Colorectal Neoplasms
Genes
Cells
Cell proliferation

Posttranslational modification of sodium channels

Pei, Z., Pan, Y. & Cummins, T., Jan 1 2018, Handbook of Experimental Pharmacology. Springer New York LLC, p. 101-124 24 p. (Handbook of Experimental Pharmacology; vol. 246).

Research output: Chapter in Book/Report/Conference proceedingChapter

Voltage-Gated Sodium Channels
Sodium Channels
Post Translational Protein Processing
Protein Isoforms
Lipoylation
2017

Absorption, Enterohepatic Circulation, and Fecal Excretion of Toxicants

Watkins, J. B. & Klaassen, C. D., Dec 15 2017, Gastrointestinal Toxicology. Elsevier Inc., Vol. 3-15. p. 99-112 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Enterohepatic Circulation
Xenobiotics
Enterocytes
Drug and Narcotic Control
Liver
2 Citations (Scopus)

EIF3 regulation of protein synthesis, tumorigenesis, and therapeutic response

Yin, J. Y., Dong, Z. & Zhang, J-T., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1507. p. 113-127 15 p. (Methods in Molecular Biology; vol. 1507).

Research output: Chapter in Book/Report/Conference proceedingChapter

Eukaryotic Initiation Factor-3
Carcinogenesis
Proteins
Peptide Initiation Factors
Therapeutics
1 Citation (Scopus)

Monitoring of permeability transition pore openings in isolated individual brain mitochondria

Broustovetski, N. & Brustovetsky, T., 2017, Neuromethods. Humana Press Inc., Vol. 123. p. 199-210 12 p. (Neuromethods; vol. 123).

Research output: Chapter in Book/Report/Conference proceedingChapter

Mitochondria
Permeability
Brain
Monitoring
Membranes
1 Citation (Scopus)

Monitoring of permeability transition pore openings in mitochondria of cultured neurons

Brustovetsky, T. & Broustovetski, N., 2017, Neuromethods. Humana Press Inc., Vol. 123. p. 239-248 10 p. (Neuromethods; vol. 123).

Research output: Chapter in Book/Report/Conference proceedingChapter

Mitochondria
Neurons
Permeability
Membranes
Monitoring
2016
2 Citations (Scopus)

The role of DNA damage and repair in toxicity to postmitotic cells caused by cancer therapies

Vasko, M., Shariati, B. & Zanville, N., Jun 21 2016, DNA Repair in Cancer Therapy: Molecular Targets and Clinical Applications: Second Edition. Elsevier Inc., p. 383-428 46 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA Repair
DNA Damage
Neoplasms
Skeletal Muscle
Poisons
2015
1 Citation (Scopus)

Mitochondrial Permeability Transition: A Look from a Different Angle

Broustovetski, N., Sep 25 2015, The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria. wiley, p. 3-30 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mitochondria
Permeability
Membranes
Mitochondrial Swelling
Cell Physiological Phenomena

Sodium channels in pain pharmacology

Cummins, T. & Waxman, S. G., Jun 1 2015, Pharmacology of Pain. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

Sodium Channels
Pharmacology
Pain
2013
2 Citations (Scopus)

Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii

Sullivan, W., Radke, J. B., Kim, K. & White, M. W., Sep 2013, Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition. Elsevier Ltd., p. 613-645 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Toxoplasma
Epigenomics
Life Cycle Stages
Gene Expression
Transcriptome

Novel developmental pathway regulation mechanisms of pten expression: Implications for human disease

Jerde, T., 2013, PTEN: Structure, Mechanisms-of-Action, Role in Cell Signaling and Regulation. Nova Science Publishers, Inc., p. 79-99 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Phosphoric Monoester Hydrolases
Cells
Biological Phenomena
Tensins
Signal transduction
1 Citation (Scopus)

The Role of Host- and Parasite-Encoded Kinases in Toxoplasma-Host Interactions

Blader, I. J., Arrizabalaga, G. & Sullivan, W., Oct 11 2013, Protein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention. wiley, p. 199-216 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Toxoplasma
Parasites
Phosphotransferases
Virulence Factors
Growth
2012
3 Citations (Scopus)

Biochemistry and Pharmacology of Human ABCC1/MRP1 and its Role in Detoxification and in Multidrug Resistance of Cancer Chemotherapy

Mo, W., Liu, J. Y. & Zhang, J-T., 2012, Recent Advances in Cancer Research and Therapy. Elsevier Inc., p. 371-404 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Multiple Drug Resistance
Biochemistry
Pharmacology
Drug Therapy
Neoplasms
6 Citations (Scopus)

The Role of DNA Damage and Repair in Neurotoxicity Caused by Cancer Therapies

Duarte, D. B. & Vasko, M., 2012, DNA Repair in Cancer Therapy. Elsevier Inc., p. 283-299 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Platinum Compounds
DNA Repair
DNA Damage
Alkylating Agents
temozolomide
2010
1 Citation (Scopus)

Absorption, Enterohepatic Circulation, and Fecal Excretion of Toxicants

Watkins, J. B. & Klaassen, C. D., Aug 12 2010, Gastrointestinal Toxicology. Elsevier Inc., Vol. 10. p. 77-91 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Enterohepatic Circulation
Enterocytes
Intestinal Absorption
Xenobiotics
Hepatocytes
2009
1 Citation (Scopus)

Voltage-Gated Sodium Channels in Peripheral Nociceptive Neurons as Targets for the Treatment of Pain

Cummins, T., Aug 5 2009, Peripheral Receptor Targets for Analgesia: Novel Approaches to Pain Management. John Wiley and Sons, p. 41-91 51 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Voltage-Gated Sodium Channels
Nociceptors
Pain
Therapeutics
2008
1 Citation (Scopus)

C. Elegans Genetic Strategies to Identify Novel Parkinson's Disease-associated Therapeutic Targets and Leads

Nass, R., 2008, Parkinson's Disease. Elsevier Inc., p. 361-368 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Parkinson Disease
Quinpirole
Cholinergic Agonists
Bromocriptine
Cholinesterase Inhibitors
5 Citations (Scopus)

Caenorhabditis Elegans Models of Parkinson's Disease. A Robust Genetic System to Identify and Characterize Endogenous and Environmental Components Involved in Dopamine Neuron Degeneration

Nass, R. & Settivari, R. S., 2008, Parkinson's Disease. Elsevier Inc., p. 347-360 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nerve Degeneration
Dopaminergic Neurons
Caenorhabditis elegans
Parkinson Disease
Synucleins
33 Citations (Scopus)

Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo

Mui, E. J., Schiehser, G. A., Milhous, W. K., Hsu, H., Roberts, C. W., Kirisits, M., Muench, S., Rice, D., Dubey, J. P., Fowble, J. W., Rathod, P. K., Queener, S., Liu, S. R., Jacobus, D. P. & McLeod, R., Mar 2008, PLoS Neglected Tropical Diseases. 3 ed. Vol. 2. e190

Research output: Chapter in Book/Report/Conference proceedingChapter

Triazines
Toxoplasma
Tetrahydrofolate Dehydrogenase
Prodrugs
Inhibitory Concentration 50

Organ Toxicology

Schwenk, M., Schwarz, L., Watkins, J. B., Pauluhn, J., Eckert, G. P., Müller, W. E., Seeber, A., Rozman, T. A., Straube, M., Rozman, K. K., Greim, H., Snyder, R., Gardner, C. R., Laskin, D. L. & Lanzl, I. M., Feb 8 2008, Toxicology and Risk Assessment: A Comprehensive Introduction. John Wiley & Sons, Ltd, p. 205-352 148 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Xenobiotics
Toxicology
Gastrointestinal Tract
Large Intestine
Small Intestine
1 Citation (Scopus)

Principles

Filser, J. G., Buters, J. T. M., Schwarz, L., Watkins, J. B., Stanley, L., Schlossmann, J., Hofmann, F., Feron, V. J., Jonker, D., Efferth, T., Kaina, B., Spielmann, H., Calow, P. & Forbes, V. E., Feb 8 2008, Toxicology and Risk Assessment: A Comprehensive Introduction. John Wiley & Sons, Ltd, p. 19-203 185 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Metabolites
Toxicokinetics
2007
3 Citations (Scopus)

Gene Regulation

White, M. W., Sullivan, W., Behnke, M. S. & Radke, J. R., 2007, Toxoplasma Gondii. Elsevier Ltd, p. 419-443 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Toxoplasma
sporozoites
Sporozoites
toxoplasmosis
bradyzoites
2005

Inherited Channelopathies of Muscle. Implications for Therapy

Cummins, T. & Ruff, R. L., 2005, From NEUROSCIENCE To NEUROLOGY. Elsevier Inc., p. 303-318 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Channelopathies
Ion Channels
Muscles
Mutation
Muscular Diseases

Neuronal Blocking Factors in Demyelinating Diseases

Cummins, T. & Waxman, S. G., 2005, Multiple Sclerosis as A Neuronal Disease. Elsevier Inc., p. 317-326 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Demyelinating Diseases
Voltage-Gated Sodium Channels
Multiple Sclerosis
Biological Toxins
Sodium
2004

DHFR and IMPDH: Enzymes exploitable as drug targets in pneumocystis

Queener, S., Jan 1 2004, Pneumocystis Pneumonia: Third Edition, Revised and Expanded. CRC Press, p. 607-630 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pneumocystis
Pentamidine
Enzymes
Pneumocystis Infections
Pharmaceutical Preparations