Pharmacology & Toxicology

Publications 1971 2020

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±3H-carazolol binding to rabbit renal cortical membranes

Hollingsead, P. S., Queener, S., Besch, H. R. & Willis, L. R., 1982, In : Clinical Research. 30, 2

Research output: Contribution to journalArticle

Rabbits
Kidney
Membranes
carazolol
41 Citations (Scopus)

14-3-3σ, the double-edged sword of human cancers

Li, Z., Liu, J. Y. & Zhang, J-T., 2009, In : American Journal of Translational Research. 1, 4, p. 326-340 15 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
Molecular Chaperones
DNA
Antineoplastic Agents
Tumors
9 Citations (Scopus)

14-3-3σ contributes to radioresistance by regulating DNA repair and cell cycle via PARP1 and CHK2

Chen, Y., Li, Z., Dong, Z., Beebe, J., Yang, K., Fu, L. & Zhang, J-T., Apr 1 2017, In : Molecular Cancer Research. 15, 4, p. 418-428 11 p.

Research output: Contribution to journalArticle

Ionizing Radiation
DNA Repair
Cell Cycle
DNA
Nonionizing Radiation
3 Citations (Scopus)

14-3-3σ regulation of and interaction with YAP1 in acquired gemcitabine resistance via promoting ribonucleotide reductase expression

Qin, L., Dong, Z. & Zhang, J-T., 2016, In : Oncotarget. 7, 14, p. 17726-17736 11 p.

Research output: Contribution to journalArticle

gemcitabine
Ribonucleotide Reductases
Adenocarcinoma
Up-Regulation
Caspase 8
44 Citations (Scopus)

2,4-diamino-5-chloroquinazoline analogues of trimetrexate and piritrexim: Synthesis and antifolate activity

Rosowsky, A., Mota, C. E., Wright, J. E. & Queener, S., 1994, In : Journal of Medicinal Chemistry. 37, 26, p. 4522-4528 7 p.

Research output: Contribution to journalArticle

Trimetrexate
Quinazolines
Folic Acid Antagonists
Toxoplasma
Tetrahydrofolate Dehydrogenase
115 Citations (Scopus)

2,4-Diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases

Gangjee, A., Vasudevan, A., Queener, S. & Kisliuk, R. L., Mar 29 1996, In : Journal of Medicinal Chemistry. 39, 7, p. 1438-1446 9 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Methylation
Toxoplasma
Benzaldehydes
37 Citations (Scopus)
Folic Acid Antagonists
Pyrimidines
Tetrahydrofolate Dehydrogenase
Thymidylate Synthase
Pathogens
18 Citations (Scopus)
Quinazolines
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
Mutation
28 Citations (Scopus)
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Trimethoprim
Toxoplasma
Liver
35 Citations (Scopus)

2,4-Diaminopyrido[3,2-d]pyrimidine inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii

Rosowsky, A., Forsch, R. A. & Queener, S., 1995, In : Journal of Medicinal Chemistry. 38, 14, p. 2615-2620 6 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Toxoplasma
Thymidine Monophosphate
Liver
68 Citations (Scopus)

2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Rosowsky, A., Mota, C. E., Wright, J. E., Freisheim, J. H., Heusner, J. J., McCormack, J. J. & Queener, S., 1993, In : Journal of Medicinal Chemistry. 36, 21, p. 3103-3112 10 p.

Research output: Contribution to journalArticle

Trimetrexate
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
Liver
42 Citations (Scopus)

2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Rosowsky, A., Papoulis, A. T. & Queener, S., 1997, In : Journal of Medicinal Chemistry. 40, 22, p. 3694-3699 6 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
Inhibitory Concentration 50
42 Citations (Scopus)

2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase

Gangjee, A., Mavandadi, F., Kisliuk, R. L., McGuire, J. J. & Queener, S., 1996, In : Journal of Medicinal Chemistry. 39, 23, p. 4563-4568 6 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Thymidylate Synthase
Liver
Rats
Glutamic Acid
2 Citations (Scopus)

3,4-methylenedioxymethamphetamine increases excitability in the dentate gyrus: Role of 5HT2A receptor-induced PGE2 signaling

Collins, S. A., Huff, C., Chiaia, N., Gudelsky, G. A. & Yamamoto, B., Mar 1 2016, In : Journal of Neurochemistry. 136, 5, p. 1074-1084 11 p.

Research output: Contribution to journalArticle

Prostaglandin E Receptors
N-Methyl-3,4-methylenedioxyamphetamine
Dentate Gyrus
Dinoprostone
Parvalbumins
17 Citations (Scopus)

4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Huang, S., Murphy, M. & Safa, A., Sep 2010, In : Molecular and Cellular Biochemistry. 342, 1-2, p. 133-142 10 p.

Research output: Contribution to journalArticle

Caspase 10
Cells
Apoptosis
Breast Neoplasms
Messenger RNA
13 Citations (Scopus)

6,7-disubstituted 2,4-diaminopteridines: Novel inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Jackson, H. C., Biggadike, K., McKilligin, E., Kinsman, O. S., Queener, S., Lane, A. & Smith, J. E., Jun 1996, In : Antimicrobial Agents and Chemotherapy. 40, 6, p. 1371-1375 5 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Pyrimethamine
Tetrahydrofolate Dehydrogenase
Toxoplasma
Trimethoprim
14 Citations (Scopus)

670 Nanometer light treatment attenuates dioxin toxicity in the developing chick embryo

Yeager, R. L., Lim, J., Millsap, D. S., Jasevicius, A. V., Sanders, R. A., Whelan, H. T., Watkins, J. B., Eells, J. T. & Henshel, D. S., 2006, In : Journal of Biochemical and Molecular Toxicology. 20, 6, p. 271-278 8 p.

Research output: Contribution to journalArticle

Dioxins
Chick Embryo
Toxicity
Light
Light emitting diodes
65 Citations (Scopus)
Folic Acid Antagonists
Pneumocystis carinii
Pyrimidines
Tetrahydrofolate Dehydrogenase
Toxoplasma
43 Citations (Scopus)
Bridged-Ring Compounds
Folic Acid Antagonists
Pneumocystis carinii
Toxoplasma
Tetrahydrofolate Dehydrogenase
4 Citations (Scopus)

7-Methyl trimethoprim analogues as inhibitors of the folate metabolizing enzymes

Gangjee, A., Lin, X. & Queener, S., May 2003, In : Journal of Heterocyclic Chemistry. 40, 3, p. 507-512 6 p.

Research output: Contribution to journalArticle

Pyrimidines
Tetrahydrofolate Dehydrogenase
Trimethoprim
Folic Acid
Benzaldehydes
30 Citations (Scopus)

8-Aminoquinolines effective against Pneumocystis carinii in vitro and in vivo

Queener, S., Bartlett, M. S., Nasr, M. & Smith, J. W., 1993, In : Antimicrobial Agents and Chemotherapy. 37, 10, p. 2166-2172 7 p.

Research output: Contribution to journalArticle

Primaquine
Pneumocystis carinii
Pneumocystis Pneumonia
Drinking Water
Nitrogen
32 Citations (Scopus)

8-Aminoquinolines from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystis pneumonia in rat models

Bartlett, M. S., Queener, S., Tidwell, R. R., Milhous, W. K., Berman, J. D., Ellis, W. Y. & Smith, J. W., 1991, In : Antimicrobial Agents and Chemotherapy. 35, 2, p. 277-282 6 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Primaquine
Pneumocystis carinii
Sulfamethoxazole Drug Combination Trimethoprim
8-aminoquinoline
32 Citations (Scopus)

Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol

Patel, R. R., Barbosa, C., Brustovetsky, T., Broustovetski, N. & Cummins, T., Aug 1 2016, In : Brain. 139, 8, p. 2164-2181 18 p.

Research output: Contribution to journalArticle

Cannabidiol
Sodium Channels
Epilepsy
Voltage-Gated Sodium Channels
Sodium
13 Citations (Scopus)

Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities

Chen, Y. W., Harris, R., Hatahet, Z. & Chou, K. M., Aug 18 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 33, p. E4556-E4564

Research output: Contribution to journalArticle

DNA Damage
Adipose Tissue
Adipocytes
Genes
Obesity
70 Citations (Scopus)

A controlled trial of the cost benefit of computerized bayesian aminoglycosde administration

Burton, M. E., Ash, C. L., Hill, D. P., Handy, T., Shepherd, M. D. & Vasko, M., Jun 1991, In : Clinical Pharmacology and Therapeutics. 49, 6, p. 685-694 10 p.

Research output: Contribution to journalArticle

Cost-Benefit Analysis
Length of Stay
Control Groups
Cost Savings
Multivariate Analysis
67 Citations (Scopus)

Activation and recovery of the PGE2-mediated sensitization of the capsaicin response in rat sensory neurons

Lopshire, J. C. & Nicol, G., Dec 1997, In : Journal of Neurophysiology. 78, 6, p. 3154-3164 11 p.

Research output: Contribution to journalArticle

Capsaicin
Sensory Receptor Cells
Dinoprostone
Cyclic GMP
Protein Kinases
47 Citations (Scopus)

Activation of calcium-independent phospholipase a2 (iPLA 2) in brain mitochondria and release of apoptogenic factors by BAX and truncated BID

Brustovetsky, T., Antonsson, B., Jemmerson, R., Dubinsky, J. M. & Broustovetski, N., Aug 2005, In : Journal of Neurochemistry. 94, 4, p. 980-994 15 p.

Research output: Contribution to journalArticle

Calcium-Independent Phospholipase A2
Mitochondria
Cytochromes c
Phospholipases A2
Brain
234 Citations (Scopus)

Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes

Southall, M. D., Li, T., Gharibova, L. S., Pei, Y., Nicol, G. & Travers, J., Jan 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 304, 1, p. 217-222 6 p.

Research output: Contribution to journalArticle

Keratinocytes
Capsaicin
Cyclooxygenase 2
Skin
vanilloid receptor subtype 1
83 Citations (Scopus)

Activation of protein kinase C augments peptide release from rat sensory neurons

Barber, L. A. & Vasko, M., Jul 1996, In : Journal of Neurochemistry. 67, 1, p. 72-80 9 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Protein Kinase C
Neurons
Rats
Phorbol 12,13-Dibutyrate
17 Citations (Scopus)

Activation of protein kinase C enhances peptide release from rat spinal cord slices

Frayer, S. M., Barber, L. A. & Vasko, M., Apr 9 1999, In : Neuroscience Letters. 265, 1, p. 17-20 4 p.

Research output: Contribution to journalArticle

Phorbol 12,13-Dibutyrate
Protein Kinase C
Spinal Cord
Peptides
Capsaicin
39 Citations (Scopus)

Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I

Zhu, W., Xu, P., Cuascut, F. X., Hall, A. K. & Oxford, G. S., Dec 12 2007, In : Journal of Neuroscience. 27, 50, p. 13770-13780 11 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Activins
Hyperalgesia
Spinal Ganglia
Sensory Receptor Cells
64 Citations (Scopus)

Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo

Queener, S., Bartlett, M. S., Richardson, J. D., Durkin, M. M., Jay, M. A. & Smith, J. W., 1988, In : Antimicrobial Agents and Chemotherapy. 32, 6, p. 807-813 7 p.

Research output: Contribution to journalArticle

Primaquine
Pneumocystis carinii
Clindamycin
Pneumocystis Infections
Pneumocystis Pneumonia
12 Citations (Scopus)

Activity of inosine analogs against Pneumocystis carinii in culture

Bartlett, M. S., Marr, J. J., Queener, S., Klein, R. S. & Smith, J. W., 1986, In : Antimicrobial Agents and Chemotherapy. 30, 1, p. 181-183 3 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Inosine
allopurinol riboside
9-deazainosine
formycin B
56 Citations (Scopus)

Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection

Queener, S., Bartlett, M. S., Jay, M. A., Durkin, M. M. & Smith, J. W., 1987, In : Antimicrobial Agents and Chemotherapy. 31, 9, p. 1323-1327 5 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Trimetrexate
Lipids
Infection
5 Citations (Scopus)

A culture method allowing production of relatively pure Pneumocystis carinii trophozoites

Durkin, M. M., Bartlett, M. S., Queener, S., Shaw, M. M. & Smith, J. W., 1989, In : Journal of Protozoology. 36, 1

Research output: Contribution to journalArticle

Pneumocystis carinii
Trophozoites
Dextrans
Microspheres
Culture Media
46 Citations (Scopus)

Acute bacterial inflammation of the mouse prostate

Boehm, B. J., Colopy, S. A., Jerde, T., Loftus, C. J. & Bushman, W., Feb 2012, In : Prostate. 72, 3, p. 307-317 11 p.

Research output: Contribution to journalArticle

Prostate
Inflammation
Interleukin-1
Uropathogenic Escherichia coli
Hyperplasia
8 Citations (Scopus)

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z-Y. & Lu, T., 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Pancreatic Neoplasms
Colorectal Neoplasms
Adenocarcinoma
Neoplasms
39 Citations (Scopus)

A decade of epigenetic research in Toxoplasma gondii

Dixon, S. E., Stilger, K. L., Elias, E. V., Naguleswaran, A. & Sullivan, W., Sep 2010, In : Molecular and Biochemical Parasitology. 173, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Parasitology
Explosions
Toxoplasma
Eukaryota
Epigenomics
15 Citations (Scopus)
Substance P
Adenosine
Spinal Cord
Potassium
Morphine
55 Citations (Scopus)

A developmental switch in acute sensitization of small dorsal root ganglion (DRG) neurons to capsaicin or noxious heating by NGF

Zhu, W., Galoyan, S. M., Petruska, J. C., Oxford, G. S. & Mendell, L. M., Nov 2004, In : Journal of Neurophysiology. 92, 5, p. 3148-3152 5 p.

Research output: Contribution to journalArticle

Capsaicin
Spinal Ganglia
Nerve Growth Factor
Heating
Neurons
1 Citation (Scopus)

A Dose-escalation Study of Recombinant Human Interleukin-18 in Combination with Ofatumumab after Autologous Peripheral Blood Stem Cell Transplantation for Lymphoma

Robertson, M., Stamatkin, C. W., Pelloso, D., Weisenbach, J., Prasad, N. K. & Safa, A., Jan 1 2018, In : Journal of Immunotherapy. 41, 3, p. 151-157 7 p.

Research output: Contribution to journalArticle

Peripheral Blood Stem Cell Transplantation
Interleukin-18
Lymphoma
Intravenous Infusions
Natural Killer Cells
3 Citations (Scopus)

Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells

Thompson, K., Chen, J., Luo, Q., Xiao, Y., Cummins, T. & Bhatwadekar, A., Feb 1 2018, In : PLoS One. 13, 2, e0193280.

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
laminin
Laminin
glycation
Down-Regulation
75 Citations (Scopus)

A Forward Genetic Screen Reveals that Calcium-dependent Protein Kinase 3 Regulates Egress in Toxoplasma

Garrison, E., Treeck, M., Ehret, E., Butz, H., Garbuz, T., Oswald, B. P., Settles, M., Boothroyd, J. & Arrizabalaga, G., Nov 2012, In : PLoS Pathogens. 8, 11, e1003049.

Research output: Contribution to journalArticle

Toxoplasma
Parasites
Ionophores
Mutation
Brain
28 Citations (Scopus)

A GCN2-Like eukaryotic initiation factor 2 kinase increases the viability of extracellular toxoplasma gondii parasites

Konrad, C., Wek, R. & Sullivan, W., Nov 2011, In : Eukaryotic Cell. 10, 11, p. 1403-1412 10 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Toxoplasma
Parasites
Phosphotransferases
Phosphorylation
79 Citations (Scopus)

Age-dependent changes in the calcium sensitivity of striatal mitochondria in mouse models of Huntington's disease

Broustovetski, N., LaFrance, R., Purl, K. J., Brustovetsky, T., Keene, C. D., Low, W. C. & Dubinsky, J. M., Jun 2005, In : Journal of Neurochemistry. 93, 6, p. 1361-1370 10 p.

Research output: Contribution to journalArticle

Corpus Striatum
Mitochondria
Huntington Disease
Calcium
Permeability
34 Citations (Scopus)

Age-related changes in regional brain mitochondria from Fischer 344 rats

LaFrance, R., Broustovetski, N., Sherburne, C., DeLong, D. & Dubinsky, J. M., Jun 2005, In : Aging Cell. 4, 3, p. 139-145 7 p.

Research output: Contribution to journalArticle

Inbred F344 Rats
Corpus Striatum
Mitochondria
Brain
Calcium
12 Citations (Scopus)

A latent ability to persist: differentiation in Toxoplasma gondii

Jeffers, V., Tampaki, Z., Kim, K. & Sullivan, W., Mar 30 2018, (Accepted/In press) In : Cellular and Molecular Life Sciences. p. 1-19 19 p.

Research output: Contribution to journalArticle

Toxoplasma
Acute Disease
Vacuoles
Vertebrates
Cysts
20 Citations (Scopus)

Albendazole inhibits Pneumocystis carinii proliferation in inoculated immunosuppressed mice

Bartlett, M. S., Edlind, T. D., Lee, C-H., Dean, R., Queener, S., Shaw, M. M. & Smith, J. W., 1994, In : Antimicrobial Agents and Chemotherapy. 38, 8, p. 1834-1837 4 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Albendazole
Pneumocystis Infections
Pneumocystis Pneumonia
Helminths
26 Citations (Scopus)

Alcohol-induced inhibition of alveolar macrophage oxidant release in vivo and in vitro

Antony, V. B., Godbey, S. W., Hott, J. W. & Queener, S., 1993, In : Alcoholism: Clinical and Experimental Research. 17, 2, p. 389-393 5 p.

Research output: Contribution to journalArticle

Alveolar Macrophages
Oxidants
Alcohols
Superoxides
Rats
36 Citations (Scopus)

Alterations in biliary excretory function by streptozotocin-induced diabetes

Watkins, J. B. & Dykstra, T. P., 1987, In : Drug Metabolism and Disposition. 15, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

Experimental Diabetes Mellitus
Streptozocin
Medical problems
Rats
Phenolsulfonphthalein