Pharmacology & Toxicology

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Discovery of potent and selective inhibitors of toxoplasma gondii thymidylate synthase for opportunistic infections

Zaware, N., Sharma, H., Yang, J., Devambatla, R. K. V., Queener, S. F., Anderson, K. S. & Gangjee, A., Dec 12 2013, In : ACS Medicinal Chemistry Letters. 4, 12, p. 1148-1151 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Disruption of a mitochondrial MutS DNA repair enzyme homologue confers drug resistance in the parasite Toxoplasma gondii

Garrison, E. M. & Arrizabalaga, G., Apr 2009, In : Molecular Microbiology. 72, 2, p. 425-441 17 p.

Research output: Contribution to journalArticle

29 Scopus citations

Disruption of NMDAR-CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model

Brittain, J. M., Pan, R., You, H., Brustovetsky, T., Brustovetsky, N., Zamponi, G. W., Lee, W. H. & Khanna, R., 2012, In : Channels. 6, 1

Research output: Contribution to journalArticle

20 Scopus citations

Disruption of the glutamate–glutamine cycle involving astrocytes in an animal model of depression for males and females

Rappeneau, V., Blaker, A., Petro, J. R., Yamamoto, B. & Shimamoto, A., Dec 6 2016, In : Frontiers in Behavioral Neuroscience. 10, DEC, 231.

Research output: Contribution to journalArticle

12 Scopus citations
23 Scopus citations

Dissection of drug-binding-induced conformational changes in P-glycoprotein

Wang, G., Pincheira, R. & Zhang, J. T., Jul 15 1998, In : European Journal of Biochemistry. 255, 2, p. 383-390 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Dissimilar mechanisms of cytochrome c release induced by octyl glucoside-activated BAX and by BAX activated with truncated BID

Li, T., Brustovetsky, T., Antonsson, B. & Brustovetsky, N., Jan 1 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 1, p. 52-62 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Distinct functional alterations in SCN8A epilepsy mutant channels

Pan, Y. & Cummins, T. R., Jan 1 2020, In : Journal of Physiology. 598, 2, p. 381-401 21 p.

Research output: Contribution to journalArticle

4 Scopus citations

Diversifying biomedical training: A synergistic intervention

Gibau, G. S., Foertsch, J., Blum, J., Brutkiewicz, R., Queener, S., Roman, A., Rhodes, S., Sturek, M., Wilkes, D. & Broxmeyer, H., 2010, In : Journal of Women and Minorities in Science and Engineering. 16, 3, p. 215-235 21 p.

Research output: Contribution to journalArticle

10 Scopus citations
3 Scopus citations

DNA lesion bypass polymerases and 4'-thio-β-D-arabinofuranosylcytosine (T-arac)

Chen, Y. W. & Chou, K. M., Dec 1 2011, In : International Journal of Biochemistry and Molecular Biology. 2, 4, p. 340-346 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

DNA methylation contributes to expression of the human neurotensin/neuromedin N gene

Dong, Z., Wang, X., Zhao, Q., Townsend, C. M. & Evers, B. M., Mar 1 1998, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 274, 3 37-3, p. G535-G543

Research output: Contribution to journalArticle

24 Scopus citations
168 Scopus citations

Dominant-negative mutants identify a role for GIRK channels in D3 dopamine receptor-mediated regulation of spontaneous secretory activity

Kuzhikandathil, E. V. & Oxford, G. S., Jun 1 2000, In : Journal of General Physiology. 115, 6, p. 697-706 10 p.

Research output: Contribution to journalArticle

41 Scopus citations
39 Scopus citations

Dopamine‐Dependent Postnatal Development of Enkephalin and Tachykinin Neurons of Rat Basal Ganglia

Sivam, S. P., Krause, J. E., Breese, G. R. & Hong, J. S., May 1991, In : Journal of Neurochemistry. 56, 5, p. 1499-1508 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Dopaminergic modulation of serotonin metabolism in rat striatum: A study with dopamine uptake inhibitor GBR-12909

Sivam, S. P., May 19 1995, In : Life Sciences. 56, 26, p. 467-472 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Dopaminergic regulation of postnatal development of dynorphin neurons in rat striatum

Sivam, S. P., Jan 1 1996, In : Neuropeptides. 30, 1, p. 103-107 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
7 Scopus citations

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels

Hodgdon, K. E., Hingtgen, C. M. & Nicol, G. D., Mar 29 2012, In : Neuroscience. 206, p. 237-244 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Dose-dependent cross-talk between the transforming growth factor-β and interleukin-1 signaling pathways

Lu, T., Tian, L., Han, Y., Vogelbaum, M. & Stark, G. R., Mar 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4365-4370 6 p.

Research output: Contribution to journalArticle

83 Scopus citations
58 Scopus citations

Downregulation of mitogen-activated protein kinases in human colon cancers

Wang, Q., Ding, Q., Dong, Z., Ehlers, R. A. & Evers, B. M., Apr 18 2000, In : Anticancer Research. 20, 1 A, p. 75-83 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Dual modulation of K channels by thyrotropin-releasing hormone in clonal pituitary cells

Dubinsky, J. M. & Oxford, G. S., Jan 1 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 12, p. 4282-4286 5 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations

Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells

Shen, F., Bailey, B. J., Chu, S., Bence, A. K., Xue, X., Erickson, P., Safa, A. R., Beck, W. T. & Erickson, L. C., Aug 2009, In : Journal of Pharmacology and Experimental Therapeutics. 330, 2, p. 423-429 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release

Mark, K. A., Quinton, M. S., Russek, S. J. & Yamamoto, B. K., Jun 20 2007, In : Journal of Neuroscience. 27, 25, p. 6823-6831 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Dynamics of aminopyridine block of potassium channels in squid axon membrane

Yeh, J. Z., Oxford, G. S., Wu, C. H. & Narahashi, T., Nov 1 1976, In : Journal of General Physiology. 68, 5, p. 519-535 17 p.

Research output: Contribution to journalArticle

Open Access
209 Scopus citations

Dynamics of aminopyridine block of potassium channels of squid axon membrane

Yeh, J. Z., Oxford, G. S., Wu, C. H. & Narahashi, T., 1976, In : Biophysical journal. 16, 2 II, p. 188a

Research output: Contribution to journalArticle

3 Scopus citations

Dynamic vs static ABCG2 inhibitors to sensitize drug resistant cancer cells

Peng, H., Qi, J., Dong, Z. & Zhang, J. T., 2010, In : PloS one. 5, 12, e15276.

Research output: Contribution to journalArticle

29 Scopus citations

Early and Late Contributions of Glutamate and CGRP to Mechanical Sensitization by Endothelin-1

Khodorova, A., Richter, J., Vasko, M. R. & Strichartz, G., Jul 1 2009, In : Journal of Pain. 10, 7, p. 740-749 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Effective targeting of the survivin dimerization interface with small-molecule inhibitors

Qi, J., Dong, Z., Liu, J., Peery, R. C., Zhang, S., Liu, J. Y. & Zhang, J. T., Jan 15 2016, In : Cancer Research. 76, 2, p. 453-462 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Effect of cysteine mutagenesis on the function and disulfide bond formation of human ABCG2

Liu, Y., Yang, Y., Qi, J., Peng, H. & Zhang, J. T., Jul 2008, In : Journal of Pharmacology and Experimental Therapeutics. 326, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Effect of Diethyl Ether on the Biliary Excretion of Acetaminophen

Watkins, J. B., Siegers, C. P. & Klaassen, C. D., Oct 1984, In : Proceedings of the Society for Experimental Biology and Medicine. 177, 1, p. 168-175 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Effect of eIF3a on response of lung cancer patients to platinum-based chemotherapy by regulating DNA repair

Yin, J. Y., Shen, J., Dong, Z. Z., Huang, Q., Zhong, M. Z., Feng, D. Y., Zhou, H. H., Zhang, J. T. & Liu, Z. Q., Jul 1 2011, In : Clinical Cancer Research. 17, 13, p. 4600-4609 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Effect of gentamicin treatment on adenylate cyclase and Na+,K+-ATPase activities in renal tissues of rats

Queener, S. F., Luft, F. C. & Hamel, F. G., Jan 1 1983, In : Antimicrobial Agents and Chemotherapy. 24, 5, p. 815-818 4 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Effect of inducers and inhibitors of glucuronidation on the biliary excretion and choleretic action of valproic acid in the rat

Watkins, J. B. & Klaassen, C. D., Jan 1 1982, In : Journal of Pharmacology and Experimental Therapeutics. 220, 2, p. 305-310 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Effect of inducers and inhibitors of glucuronidation on the choleretic action of valproic acid in the rat

Watkins, J. B. & Klaassen, C. D., Jan 1 1981, In : Federation Proceedings. 40, 6, 1 p.

Research output: Contribution to journalArticle

Effect of insulin-dependent diabetes on hepatocyte ploidization

Watkins, J. B. & Schwarz, L. R., Jan 1 1990, In : European Journal of Pharmacology. 183, 6, p. 2096-2097 2 p.

Research output: Contribution to journalArticle

Effect of melatonin on phase I and II biotransformation enzymes in streptozotocin-induced diabetic rats

Maritim, A. C., Moore, B. H., Sanders, R. A. & Watkins, J. B., Jan 1 2000, In : International Journal of Toxicology. 19, 4, p. 277-283 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effect of metabolic inhibition on the excitability of isolated hippocampal CA1 neurons: Developmental aspects

Cummins, T. R., Donnelly, D. F. & Haddad, G. G., 1991, In : Journal of Neurophysiology. 66, 5, p. 1471-1482 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Effect of microsomal enzyme inducers on the soluble enzymes of hepatic phase II biotransformation

Thompson, T. N., Watkins, J. B., Gregus, Z. & Klaassen, C. D., Dec 1982, In : Toxicology and Applied Pharmacology. 66, 3, p. 400-408 9 p.

Research output: Contribution to journalArticle

64 Scopus citations
7 Scopus citations

Effect of repeated oral administration of taurocholate on hepatic excretory function in the rat

Watkins, J. B. & Klaasen, C. D., Jan 1 1980, In : Pharmacologist. 22, 3, 1 p.

Research output: Contribution to journalArticle

Effect of repeated oral administration of taurocholate on hepatic excretory function in the rat

Watkins, J. B. & Klaassen, C. D., Jan 1 1981, In : Journal of Pharmacology and Experimental Therapeutics. 218, 1, p. 182-187 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Effect of sodium orthovanadate on the hepatobiliary clearance of rose bengal in streptozotocin-induced diabetic rats

Watkins, J. B., Bauman, M. E. & Beaty, T. M., Dec 14 1993, In : Biochemical Pharmacology. 46, 12, p. 2269-2276 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effect of volatile anesthetics on the hepatic UDP-glucuronic acid pathway in mice

Watkins, J. B., Engles, D. R. & Beck, L. V., Aug 15 1990, In : Biochemical Pharmacology. 40, 4, p. 731-735 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents

Dolan, M. E., Frydman, B., Thompson, C. B., Diamond, A. M., Garbiras, B. J., Safa, A. R., Beck, W. T. & Marton, L. J., 1998, In : Anti-Cancer Drugs. 9, 5, p. 437-448 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Effects of 8-aminoquinolines on the ultrastructural morphology of Pneumocystis carinii

Goheen, M. P., Bartlett, M. S., Shaw, M. M., Queener, S. F. & Smith, J. W., 1993, In : International Journal of Experimental Pathology. 74, 4, p. 379-387 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Effects of acetazolamide on the renal excretion of phosphate in hypoparathyroidism and pseudohypoparathyroidism

Sinha, T. K., Allen, D. O., Queener, S. F. & Bell, N. H., Jun 1977, In : The Journal of Laboratory and Clinical Medicine. 89, 6, p. 1188-1197 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effects of aldose reductase inhibitors on antioxidant defense in rat and rabbit liver

Thomas, T., Rauscher, F., Sanders, R., Veltman, J. & Watkins, J. B., Jan 1 2000, In : Toxicological Sciences. 53, 1, p. 145-149 5 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations