Pharmacology & Toxicology

Publications 1971 2020

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2017
9 Citations (Scopus)

14-3-3σ contributes to radioresistance by regulating DNA repair and cell cycle via PARP1 and CHK2

Chen, Y., Li, Z., Dong, Z., Beebe, J., Yang, K., Fu, L. & Zhang, J-T., Apr 1 2017, In : Molecular Cancer Research. 15, 4, p. 418-428 11 p.

Research output: Contribution to journalArticle

Ionizing Radiation
DNA Repair
Cell Cycle
DNA
Nonionizing Radiation
8 Citations (Scopus)

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z-Y. & Lu, T., 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Pancreatic Neoplasms
Colorectal Neoplasms
Adenocarcinoma
Neoplasms
10 Citations (Scopus)

A novel dense granule protein, GRA41, regulates timing of egress and calcium sensitivity in Toxoplasma gondii

Lafavers, K. A., Márquez-Nogueras, K. M., Coppens, I., Moreno, S. N. J. & Arrizabalaga, G., 2017, (Accepted/In press) In : Cellular Microbiology.

Research output: Contribution to journalArticle

Toxoplasma
Calcium
Parasites
Vacuoles
Proteins
7 Citations (Scopus)

APC loss in breast cancer leads to doxorubicin resistance via STAT3 activation

VanKlompenberg, M. K., Leyden, E., Arnason, A. H., Zhang, J-T., Stefanski, C. D. & Prosperi, J., Jan 1 2017, In : Oncotarget. 8, 61, p. 102868-102879 12 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Adenomatous Polyposis Coli
Mouse mammary tumor virus
Doxorubicin
Transcriptional Activation
12 Citations (Scopus)

A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch

Ramsden, C. E., Domenichiello, A. F., Yuan, Z. X., Sapio, M. R., Keyes, G. S., Mishra, S. K., Gross, J. R., Majchrzak-Hong, S., Zamora, D., Horowitz, M. S., Davis, J. M., Sorokin, A. V., Dey, A., LaPaglia, D. M., Wheeler, J. J., Vasko, M., Mehta, N. N., Mannes, A. J. & Iadarola, M. J., Aug 22 2017, In : Science Signaling. 10, 493, 5241.

Research output: Contribution to journalArticle

Linoleic Acid
Systems Analysis
Skin
Derivatives
Rats
18 Citations (Scopus)

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB

Chen, M., Liang, J., Ji, H., Yang, Z., Altilia, S., Hu, B., Schronce, A., McDermott, M. S. J., Schools, G. P., Lim, C. U., Oliver, D., Shtutman, M. S., Lu, T., Stark, G. R., Porter, D. C., Broude, E. V. & Roninson, I. B., Sep 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. 10208-10213 6 p.

Research output: Contribution to journalArticle

Transcription Factors
Phosphotransferases
Genes
Mediator Complex
RNA Polymerase III
6 Citations (Scopus)

Chronic-stress-induced behavioral changes associated with subregion-selective serotonin cell death in the dorsal raphe

Natarajan, R., Forrester, L., Chiaia, N. L. & Yamamoto, B., 2017, In : Journal of Neuroscience. 37, 26, p. 6214-6223 10 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
Serotonin
Cell Death
Carisoprodol
Reversal Learning
3 Citations (Scopus)

Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases

Prabhu, L., Chen, L., Wei, H., Demir, Ö., Safa, A., Zeng, L., Amaro, R. E., O'Neil, B. H., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Molecular BioSystems. 13, 12, p. 2509-2520 12 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Histones
Methylation
Arginine
Streptavidin
11 Citations (Scopus)

Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model

Ozcelikkale, A., Shin, K., Noe-Kim, V., Elzey, B. D., Dong, Z., Zhang, J-T., Kim, K., Kwon, I. C., Park, K. & Han, B., Nov 28 2017, In : Journal of Controlled Release. 266, p. 129-139 11 p.

Research output: Contribution to journalArticle

Microfluidics
Doxorubicin
Tumor Microenvironment
Breast Neoplasms
Drug Resistance
2 Citations (Scopus)
DNA Repair
DNA Damage
Sensory Receptor Cells
Calcitonin Gene-Related Peptide
Inflammation
4 Citations (Scopus)

FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons

Barbosa, C., Xiao, Y., Johnson, A. J., Xie, W., Strong, J. A., Zhang, J. M. & Cummins, T., Feb 1 2017, In : Pflugers Archiv European Journal of Physiology. 469, 2, p. 195-212 18 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Sensory Receptor Cells
Neurons
Protein Isoforms
Sodium
5 Citations (Scopus)

Fluorescein isothiocyanate (FITC)-dextran extravasation as a measure of blood-brain barrier permeability

Natarajan, R., Northrop, N. & Yamamoto, B., Apr 1 2017, In : Current Protocols in Neuroscience. 2017, p. 9.58.1-9.58.15

Research output: Contribution to journalArticle

Blood-Brain Barrier
Permeability
Brain
Microvessels
fluorescein isothiocyanate dextran
1 Citation (Scopus)

G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans

Wang, J., Luo, J., Aryal, D. K., Wetsel, W. C., Nass, R. & Benovic, J. L., Apr 7 2017, In : Journal of Biological Chemistry. 292, 14, p. 5943-5956 14 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinase 2
Monoamine Oxidase
Caenorhabditis elegans
Metabolism
Serotonin
10 Citations (Scopus)

HIV and drug abuse mediate astrocyte senescence in a β-catenin-dependent manner leading to neuronal toxicity

Yu, C., Narasipura, S. D., Richards, M. H., Hu, X. T., Yamamoto, B. & Al-Harthi, L., 2017, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Catenins
Astrocytes
Substance-Related Disorders
Methamphetamine
HIV
21 Citations (Scopus)

Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency

Zhang, M., Gallego-Delgado, J., Fernandez-Arias, C., Waters, N. C., Rodriguez, A., Tsuji, M., Wek, R., Nussenzweig, V. & Sullivan, W., Dec 13 2017, In : Cell Host and Microbe. 22, 6, p. 766-776.e4

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Plasmodium
Phosphotransferases
Parasites
Phosphorylation
2 Citations (Scopus)
Atovaquone
Toxoplasma
Toxoplasma gondii
Mitochondrial DNA
Plasticity
3 Citations (Scopus)

Methamphetamine-Induced Brain Injury and Alcohol Drinking

Blaker, A. L. & Yamamoto, B., Aug 30 2017, (Accepted/In press) In : Journal of NeuroImmune Pharmacology. p. 1-11 11 p.

Research output: Contribution to journalArticle

Methamphetamine
Alcohol Drinking
Brain Injuries
Drinking
Serotonin
12 Citations (Scopus)

Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii

Ovciarikova, J., Lemgruber, L., Stilger, K. L., Sullivan, W. & Sheiner, L., Feb 16 2017, In : Scientific Reports. 7, 42746.

Research output: Contribution to journalArticle

Toxoplasma
Mitochondria
Parasites
Membranes
Toxoplasmosis
9 Citations (Scopus)

Novel serine 176 phosphorylation of YBX1 activates NF-κB in colon cancer

Martin, M., Hua, L., Wang, B., Wei, H., Prabhu, L., Hartley, A. V., Jiang, G., Liu, Y. & Lu, T., Feb 24 2017, In : Journal of Biological Chemistry. 292, 8, p. 3433-3444 12 p.

Research output: Contribution to journalArticle

Y-Box-Binding Protein 1
Phosphorylation
Colonic Neoplasms
Serine
Neoplasms
1 Citation (Scopus)
Calcitonin Gene-Related Peptide
Sensory Receptor Cells
Paclitaxel
Membranes
Phorbol 12,13-Dibutyrate
5 Citations (Scopus)

Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Wang, H., Nguyen, A., Kamocka, M., Cai, W., Cohen-Gadol, A., Halum, S. L., Sarkaria, J. N., Pollok, K. & Safa, A., Dec 1 2017, In : Journal of Neurosurgery. 127, 6, p. 1219-1230 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
Stem Cells
Growth
Neoplasms
5 Citations (Scopus)

Targeting of tail-anchored membrane proteins to subcellular organelles in Toxoplasma gondii

Padgett, L. R., Arrizabalaga, G. & Sullivan, W., Mar 1 2017, In : Traffic. 18, 3, p. 149-158 10 p.

Research output: Contribution to journalArticle

Toxoplasma
Organelles
Tail
Membrane Proteins
Proteins
3 Citations (Scopus)

TgPRELID, a mitochondrial protein linked to multidrug resistance in the parasite Toxoplasma gondii

Jeffers, V., Kamau, E. T., Srinivasan, A. R., Harper, J., Sankaran, P., Post, S. E., Varberg, J. M., Sullivan, W. & Boyle, J. P., Jan 1 2017, In : mSphere. 2, 1, e00229-16.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Toxoplasma
Multiple Drug Resistance
Parasites
Mutation
3 Citations (Scopus)

The common parasite Toxoplasma gondii induces prostatic inflammation and microglandular hyperplasia in a mouse model

Colinot, D. L., Garbuz, T., Bosland, M. C., Wang, L., Rice, S. E., Sullivan, W., Arrizabalaga, G. & Jerde, T., 2017, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Toxoplasma
Hyperplasia
Parasites
Inflammation
Prostate
8 Citations (Scopus)

The role of charge in the toxicity of polymer-coated cerium oxide nanomaterials to Caenorhabditis elegans

Arndt, D. A., Oostveen, E. K., Triplett, J., Allan Butterfield, D., Tsyusko, O. V., Collin, B., Starnes, D. L., Cai, J., Klein, J. B., Nass, R. & Unrine, J. M., Oct 1 2017, In : Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 201, p. 1-10 10 p.

Research output: Contribution to journalArticle

Nanostructures
Caenorhabditis elegans
Nanostructured materials
Toxicity
Polymers
8 Citations (Scopus)

The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor

Khodorova, A., Nicol, G. & Strichartz, G., Jan 6 2017, In : Neuroscience. 340, p. 384-397 14 p.

Research output: Contribution to journalArticle

Nerve Growth Factor Receptor
Hyperalgesia
Nerve Growth Factor
Sphingomyelin Phosphodiesterase
Injections
12 Citations (Scopus)

Toxoplasma gondii AP2IX-4 regulates gene expression during bradyzoite development

Huang, S., Holmes, M. J., Radke, J. B., Hong, D. P., Liu, T. K., White, M. W. & Sullivan, W., Mar 1 2017, In : mSphere. 2, 2, e00054-17.

Research output: Contribution to journalArticle

Toxoplasma
Cysts
Gene Expression
Parasites
Toxoplasmosis
1 Citation (Scopus)

Toxoplasma gondii-positive human sera recognise intracellular tachyzoites and bradyzoites with diverse patterns of immunoreactivity

Roiko, M. S., LaFavers, K., Leland, D. & Arrizabalaga, G., Jan 1 2017, (Accepted/In press) In : International Journal for Parasitology.

Research output: Contribution to journalArticle

Toxoplasma
Parasites
Antibodies
Immunoglobulin G
Serologic Tests
13 Citations (Scopus)

Translational Control in the Latency of Apicomplexan Parasites

Holmes, M. J., Augusto, L. D. S., Zhang, M., Wek, R. & Sullivan, W., 2017, (Accepted/In press) In : Trends in Parasitology.

Research output: Contribution to journalArticle

Parasites
Eukaryotic Initiation Factor-2
Plasmodium
Toxoplasma
Protein Biosynthesis
2016
3 Citations (Scopus)

14-3-3σ regulation of and interaction with YAP1 in acquired gemcitabine resistance via promoting ribonucleotide reductase expression

Qin, L., Dong, Z. & Zhang, J-T., 2016, In : Oncotarget. 7, 14, p. 17726-17736 11 p.

Research output: Contribution to journalArticle

gemcitabine
Ribonucleotide Reductases
Adenocarcinoma
Up-Regulation
Caspase 8
2 Citations (Scopus)

3,4-methylenedioxymethamphetamine increases excitability in the dentate gyrus: Role of 5HT2A receptor-induced PGE2 signaling

Collins, S. A., Huff, C., Chiaia, N., Gudelsky, G. A. & Yamamoto, B., Mar 1 2016, In : Journal of Neurochemistry. 136, 5, p. 1074-1084 11 p.

Research output: Contribution to journalArticle

Prostaglandin E Receptors
N-Methyl-3,4-methylenedioxyamphetamine
Dentate Gyrus
Dinoprostone
Parvalbumins
32 Citations (Scopus)

Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol

Patel, R. R., Barbosa, C., Brustovetsky, T., Broustovetski, N. & Cummins, T., Aug 1 2016, In : Brain. 139, 8, p. 2164-2181 18 p.

Research output: Contribution to journalArticle

Cannabidiol
Sodium Channels
Epilepsy
Voltage-Gated Sodium Channels
Sodium
9 Citations (Scopus)

An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite toxoplasma gondii

Liu, J., He, Y., Benmerzouga, I., Sullivan, W., Morrissette, N. S., Murray, J. M. & Hu, K., Feb 1 2016, In : Molecular Biology of the Cell. 27, 3, p. 549-571 23 p.

Research output: Contribution to journalArticle

Toxoplasma
Microtubules
Parasites
Proteins
Polymers
8 Citations (Scopus)

An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer

Kedage, V., Selvaraj, N., Nicholas, T. R., Budka, J. A., Plotnik, J. P., Jerde, T. & Hollenhorst, P., Oct 25 2016, In : Cell Reports. 17, 5, p. 1289-1301 13 p.

Research output: Contribution to journalArticle

RNA-Binding Protein EWS
Ewing's Sarcoma
Prostate
Prostatic Neoplasms
Tumors
4 Citations (Scopus)

Aromatase inhibitors augment nociceptive behaviors in rats and enhance the excitability of sensory neurons

Robarge, J. D., Duarte, D. B., Shariati, B., Wang, R., Flockhart, D. A. & Vasko, M., Jul 1 2016, In : Experimental Neurology. 281, p. 53-65 13 p.

Research output: Contribution to journalArticle

letrozole
Aromatase Inhibitors
Sensory Receptor Cells
Hypersensitivity
exemestane
12 Citations (Scopus)
Lipoylation
arrhythmia
muscle cells
Sodium Channels
NAV1.5 Voltage-Gated Sodium Channel
4 Citations (Scopus)

Coordinated induction of cell survival signaling in the inflamed microenvironment of the prostate

Mcilwain, D. W., Zoetemelk, M., Myers, J. D., Edwards, M. T., Snider, B. M. & Jerde, T., 2016, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Prostate
Cell Survival
Inflammation
Autophagy
Immunoblotting
7 Citations (Scopus)

Disruption of the glutamate–glutamine cycle involving astrocytes in an animal model of depression for males and females

Rappeneau, V., Blaker, A., Petro, J. R., Yamamoto, B. & Shimamoto, A., Dec 6 2016, In : Frontiers in Behavioral Neuroscience. 10, DEC, 231.

Research output: Contribution to journalArticle

Astrocytes
Animal Models
Glutamic Acid
Depression
Glutamine
17 Citations (Scopus)

Effective targeting of the survivin dimerization interface with small-molecule inhibitors

Qi, J., Dong, Z., Liu, J., Peery, R. C., Zhang, S., Liu, J. Y. & Zhang, J-T., Jan 15 2016, In : Cancer Research. 76, 2, p. 453-462 10 p.

Research output: Contribution to journalArticle

Dimerization
Oncogene Proteins
Proteasome Endopeptidase Complex
Computer Simulation
Antineoplastic Agents
18 Citations (Scopus)

Emerging targets for glioblastoma stem cell therapy

Safa, A., Saadatzadeh, M. R., Cohen-Gadol, A., Pollok, K. & Bijangi-Vishehsaraei, K., 2016, In : Journal of Biomedical Research. 30, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell- and Tissue-Based Therapy
Stem cells
Stem Cells
Tumors
6 Citations (Scopus)

Epac activation sensitizes rat sensory neurons through activation of Ras

Shariati, B., Thompson, E. L., Nicol, G. & Vasko, M., Jan 1 2016, In : Molecular and Cellular Neuroscience. 70, p. 54-67 14 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Action Potentials
Calcitonin Gene-Related Peptide
Perfusion
Capsaicin
1 Citation (Scopus)

Erratum: Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo (Oncogene (2016) 35 (783-792) DOI:10.1038/onc.2015.215)

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H. E., Zhang, Z. Y., Liu, J. Y. & Zhang, J-T., Feb 11 2016, In : Oncogene. 35, 6, p. 802 1 p.

Research output: Contribution to journalArticle

Oncogenes
Neoplasm Metastasis
Gene Expression
DNA
Growth
12 Citations (Scopus)

FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1

Wu, X., Dong, Z., Wang, C. J., Barlow, L. J., Fako, V., Serrano, M. A., Zou, Y., Liu, J. Y. & Zhang, J-T., Nov 8 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 45, p. E6965-E6973

Research output: Contribution to journalArticle

Fatty Acid Synthases
DNA Repair
Palmitates
Lipids
Poly (ADP-Ribose) Polymerase-1
12 Citations (Scopus)

Garcinol inhibits GCN5-mediated lysine acetyltransferase activity and prevents replication of the parasite Toxoplasma gondii

Jeffers, V., Gao, H., Checkley, L. A., Liu, Y., Ferdig, M. T. & Sullivan, W., Apr 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 4, p. 2164-2170 7 p.

Research output: Contribution to journalArticle

Toxoplasma
Parasites
Acetylation
Gene Expression
Histones
11 Citations (Scopus)

Glucose-independent acetate metabolism promotes melanoma cell survival and tumor growth

Lakhter, A. J., Hamilton, J., Konger, R., Broustovetski, N., Broxmeyer, H. & Naidu, S., Oct 14 2016, In : Journal of Biological Chemistry. 291, 42, p. 21869-21879 11 p.

Research output: Contribution to journalArticle

Metabolism
Tumors
Melanoma
Cell Survival
Acetates
18 Citations (Scopus)
DNA-(Apurinic or Apyrimidinic Site) Lyase
Peripheral Nervous System Diseases
oxaliplatin
Drug Therapy
Sensory Receptor Cells
3 Citations (Scopus)
Cyclic AMP-Dependent Protein Kinases
Dinoprostone
Eicosanoids
Calcitonin Gene-Related Peptide
Capsaicin
1 Citation (Scopus)

MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate

Huff, C. L., Morano, R. L., Herman, J. P., Yamamoto, B. & Gudelsky, G. A., Dec 1 2016, In : NeuroToxicology. 57, p. 282-290 9 p.

Research output: Contribution to journalArticle

Glutamate Decarboxylase
Methamphetamine
Neurons
Glutamic Acid
Hippocampus

Meet our editorial board member

Sheets, P., 2016, In : Current Drug Targets. 17, 3, p. 253 1 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Membrane patches as ion channel probes for scanning ion conductance microscopy

Shi, W., Zeng, Y., Zhou, L., Xiao, Y., Cummins, T. & Baker, L. A., 2016, In : Faraday Discussions. 193, p. 81-97 17 p.

Research output: Contribution to journalArticle

Ion Channels
Microscopy
Microscopic examination
Ions
membranes