Pharmacology & Toxicology

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2018
4 Scopus citations

TgDrpC, an atypical dynamin-related protein in Toxoplasma gondii, is associated with vesicular transport factors and parasite division

Heredero-Bermejo, I., Varberg, J. M., Charvat, R., Jacobs, K., Garbuz, T., Sullivan, W. & Arrizabalaga, G., Jan 1 2018, (Accepted/In press) In : Molecular Microbiology.

Research output: Contribution to journalArticle

6 Scopus citations

TgTKL1 is a unique plant-like nuclear kinase that plays an essential role in acute toxoplasmosis

Varberg, J. M., Coppens, I., Arrizabalaga, G. & Gaji, R. Y., Mar 1 2018, In : mBio. 9, 2, e00301-18.

Research output: Contribution to journalArticle

3 Scopus citations
10 Scopus citations

Toxoplasma gondii-positive human sera recognise intracellular tachyzoites and bradyzoites with diverse patterns of immunoreactivity

Roiko, M. S., LaFavers, K., Leland, D. & Arrizabalaga, G., Mar 2018, In : International Journal for Parasitology. 48, 3-4, p. 225-232 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis

Radke, J. B., Worth, D., Hong, D., Huang, S., Sullivan, W. J., Wilson, E. H. & White, M. W., May 2018, In : PLoS pathogens. 14, 5, e1007035.

Research output: Contribution to journalArticle

16 Scopus citations
2017

14-3-3σ contributes to radioresistance by regulating DNA repair and cell cycle via PARP1 and CHK2

Chen, Y., Li, Z., Dong, Z., Beebe, J., Yang, K., Fu, L. & Zhang, J. T., Apr 2017, In : Molecular Cancer Research. 15, 4, p. 418-428 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

A novel dense granule protein, GRA41, regulates timing of egress and calcium sensitivity in Toxoplasma gondii

LaFavers, K. A., Márquez-Nogueras, K. M., Coppens, I., Moreno, S. N. J. & Arrizabalaga, G., Sep 2017, In : Cellular Microbiology. 19, 9, e12749.

Research output: Contribution to journalArticle

11 Scopus citations

APC loss in breast cancer leads to doxorubicin resistance via STAT3 activation

VanKlompenberg, M. K., Leyden, E., Arnason, A. H., Zhang, J. T., Stefanski, C. D. & Prosperi, J. R., Jan 1 2017, In : Oncotarget. 8, 61, p. 102868-102879 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch

Ramsden, C. E., Domenichiello, A. F., Yuan, Z. X., Sapio, M. R., Keyes, G. S., Mishra, S. K., Gross, J. R., Majchrzak-Hong, S., Zamora, D., Horowitz, M. S., Davis, J. M., Sorokin, A. V., Dey, A., LaPaglia, D. M., Wheeler, J. J., Vasko, M. R., Mehta, N. N., Mannes, A. J. & Iadarola, M. J., Aug 22 2017, In : Science Signaling. 10, 493, 5241.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB

Chen, M., Liang, J., Ji, H., Yang, Z., Altilia, S., Hu, B., Schronce, A., McDermott, M. S. J., Schools, G. P., Lim, C. U., Oliver, D., Shtutman, M. S., Lu, T., Stark, G. R., Porter, D. C., Broude, E. V. & Roninson, I. B., Sep 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. 10208-10213 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Chronic-stress-induced behavioral changes associated with subregion-selective serotonin cell death in the dorsal raphe

Natarajan, R., Forrester, L., Chiaia, N. L. & Yamamoto, B., 2017, In : Journal of Neuroscience. 37, 26, p. 6214-6223 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases

Prabhu, L., Chen, L., Wei, H., Demir, Ö., Safa, A., Zeng, L., Amaro, R. E., O'Neil, B. H., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Molecular BioSystems. 13, 12, p. 2509-2520 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model

Ozcelikkale, A., Shin, K., Noe-Kim, V., Elzey, B. D., Dong, Z., Zhang, J. T., Kim, K., Kwon, I. C., Park, K. & Han, B., Nov 28 2017, In : Journal of Controlled Release. 266, p. 129-139 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
3 Scopus citations

FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons

Barbosa, C., Xiao, Y., Johnson, A. J., Xie, W., Strong, J. A., Zhang, J. M. & Cummins, T. R., Feb 1 2017, In : Pflugers Archiv European Journal of Physiology. 469, 2, p. 195-212 18 p.

Research output: Contribution to journalArticle

6 Scopus citations

Fluorescein isothiocyanate (FITC)-dextran extravasation as a measure of blood-brain barrier permeability

Natarajan, R., Northrop, N. & Yamamoto, B., Apr 1 2017, In : Current Protocols in Neuroscience. 2017, p. 9.58.1-9.58.15

Research output: Contribution to journalArticle

5 Scopus citations

G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans

Wang, J., Luo, J., Aryal, D. K., Wetsel, W. C., Nass, R. & Benovic, J. L., Apr 7 2017, In : Journal of Biological Chemistry. 292, 14, p. 5943-5956 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

HIV and drug abuse mediate astrocyte senescence in a β-catenin-dependent manner leading to neuronal toxicity

Yu, C., Narasipura, S. D., Richards, M. H., Hu, X. T., Yamamoto, B. & Al-Harthi, L., Oct 2017, In : Aging Cell. 16, 5, p. 956-965 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency

Zhang, M., Gallego-Delgado, J., Fernandez-Arias, C., Waters, N. C., Rodriguez, A., Tsuji, M., Wek, R. C., Nussenzweig, V. & Sullivan, W. J., Dec 13 2017, In : Cell Host and Microbe. 22, 6, p. 766-776.e4

Research output: Contribution to journalArticle

27 Scopus citations
3 Scopus citations

Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii

Ovciarikova, J., Lemgruber, L., Stilger, K. L., Sullivan, W. J. & Sheiner, L., Feb 16 2017, In : Scientific reports. 7, 42746.

Research output: Contribution to journalArticle

14 Scopus citations

Novel serine 176 phosphorylation of YBX1 activates NF-κB in colon cancer

Martin, M., Hua, L., Wang, B., Wei, H., Prabhu, L., Hartley, A. V., Jiang, G., Liu, Y. & Lu, T., Feb 24 2017, In : Journal of Biological Chemistry. 292, 8, p. 3433-3444 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Oxidative metabolism and Ca2+ handling in striatal mitochondria from YAC128 mice, a model of Huntington's disease

Hamilton, J., Brustovetsky, T. & Brustovetsky, N., Oct 2017, In : Neurochemistry International. 109, p. 24-33 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2 Scopus citations

Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Wang, H., Nguyen, A., Kamocka, M. M., Cai, W., Cohen-Gadol, A. A., Halum, S. L., Sarkaria, J. N., Pollok, K. E. & Safa, A. R., Dec 2017, In : Journal of neurosurgery. 127, 6, p. 1219-1230 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Targeting of tail-anchored membrane proteins to subcellular organelles in Toxoplasma gondii

Padgett, L. R., Arrizabalaga, G. & Sullivan, W. J., Mar 1 2017, In : Traffic. 18, 3, p. 149-158 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

TgPRELID, a mitochondrial protein linked to multidrug resistance in the parasite Toxoplasma gondii

Jeffers, V., Kamau, E. T., Srinivasan, A. R., Harper, J., Sankaran, P., Post, S. E., Varberg, J. M., Sullivan, W. J. & Boyle, J. P., Jan 1 2017, In : mSphere. 2, 1, e00229-16.

Research output: Contribution to journalArticle

6 Scopus citations

The common parasite Toxoplasma gondii induces prostatic inflammation and microglandular hyperplasia in a mouse model

Colinot, D. L., Garbuz, T., Bosland, M. C., Wang, L., Rice, S. E., Sullivan, W., Arrizabalaga, G. & Jerde, T., 2017, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

4 Scopus citations

The role of charge in the toxicity of polymer-coated cerium oxide nanomaterials to Caenorhabditis elegans

Arndt, D. A., Oostveen, E. K., Triplett, J., Allan Butterfield, D., Tsyusko, O. V., Collin, B., Starnes, D. L., Cai, J., Klein, J. B., Nass, R. & Unrine, J. M., Oct 2017, In : Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 201, p. 1-10 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor

Khodorova, A., Nicol, G. D. & Strichartz, G., Jan 6 2017, In : Neuroscience. 340, p. 384-397 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Toxoplasma gondii AP2IX-4 regulates gene expression during bradyzoite development

Huang, S., Holmes, M. J., Radke, J. B., Hong, D. P., Liu, T. K., White, M. W. & Sullivan, W. J., Mar 1 2017, In : mSphere. 2, 2, e00054-17.

Research output: Contribution to journalArticle

15 Scopus citations
2016

14-3-3σ regulation of and interaction with YAP1 in acquired gemcitabine resistance via promoting ribonucleotide reductase expression

Qin, L., Dong, Z. & Zhang, J. T., Jan 1 2016, In : Oncotarget. 7, 14, p. 17726-17736 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

3,4-methylenedioxymethamphetamine increases excitability in the dentate gyrus: Role of 5HT2A receptor-induced PGE2 signaling

Collins, S. A., Huff, C., Chiaia, N., Gudelsky, G. A. & Yamamoto, B. K., Mar 1 2016, In : Journal of Neurochemistry. 136, 5, p. 1074-1084 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol

Patel, R. R., Barbosa, C., Brustovetsky, T., Brustovetsky, N. & Cummins, T. R., Aug 1 2016, In : Brain. 139, 8, p. 2164-2181 18 p.

Research output: Contribution to journalArticle

42 Scopus citations

An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite toxoplasma gondii

Liu, J., He, Y., Benmerzouga, I., Sullivan, W. J., Morrissette, N. S., Murray, J. M. & Hu, K., Feb 1 2016, In : Molecular Biology of the Cell. 27, 3, p. 549-571 23 p.

Research output: Contribution to journalArticle

9 Scopus citations

An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer

Kedage, V., Selvaraj, N., Nicholas, T. R., Budka, J. A., Plotnik, J. P., Jerde, T. J. & Hollenhorst, P. C., Oct 25 2016, In : Cell Reports. 17, 5, p. 1289-1301 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Aromatase inhibitors augment nociceptive behaviors in rats and enhance the excitability of sensory neurons

Robarge, J. D., Duarte, D. B., Shariati, B., Wang, R., Flockhart, D. A. & Vasko, M., Jul 1 2016, In : Experimental Neurology. 281, p. 53-65 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
15 Scopus citations

Coordinated induction of cell survival signaling in the inflamed microenvironment of the prostate

McIlwain, D. W., Zoetemelk, M., Myers, J. D., Edwards, M. T., Snider, B. M. & Jerde, T. J., Jun 1 2016, In : Prostate. 76, 8, p. 722-734 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Disruption of the glutamate–glutamine cycle involving astrocytes in an animal model of depression for males and females

Rappeneau, V., Blaker, A., Petro, J. R., Yamamoto, B. & Shimamoto, A., Dec 6 2016, In : Frontiers in Behavioral Neuroscience. 10, DEC, 231.

Research output: Contribution to journalArticle

9 Scopus citations

Effective targeting of the survivin dimerization interface with small-molecule inhibitors

Qi, J., Dong, Z., Liu, J., Peery, R. C., Zhang, S., Liu, J. Y. & Zhang, J. T., Jan 15 2016, In : Cancer Research. 76, 2, p. 453-462 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Epac activation sensitizes rat sensory neurons through activation of Ras

Shariati, B., Thompson, E. L., Nicol, G. & Vasko, M., Jan 1 2016, In : Molecular and Cellular Neuroscience. 70, p. 54-67 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1

Wu, X., Dong, Z., Wang, C. J., Barlow, L. J., Fako, V., Serrano, M. A., Zou, Y., Liu, J. Y. & Zhang, J. T., Nov 8 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 45, p. E6965-E6973

Research output: Contribution to journalArticle

18 Scopus citations

Garcinol inhibits GCN5-mediated lysine acetyltransferase activity and prevents replication of the parasite Toxoplasma gondii

Jeffers, V., Gao, H., Checkley, L. A., Liu, Y., Ferdig, M. T. & Sullivan, W. J., Apr 2016, In : Antimicrobial Agents and Chemotherapy. 60, 4, p. 2164-2170 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Glucose-independent acetate metabolism promotes melanoma cell survival and tumor growth

Lakhter, A. J., Hamilton, J., Konger, R., Broustovetski, N., Broxmeyer, H. & Naidu, S., Oct 14 2016, In : Journal of Biological Chemistry. 291, 42, p. 21869-21879 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
21 Scopus citations
3 Scopus citations

MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate

Huff, C. L., Morano, R. L., Herman, J. P., Yamamoto, B. K. & Gudelsky, G. A., Dec 1 2016, In : NeuroToxicology. 57, p. 282-290 9 p.

Research output: Contribution to journalArticle

2 Scopus citations