Pharmacology & Toxicology

Publications 1971 2020

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2003
186 Citations (Scopus)

Effects of α-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats

Maritim, A. C., Sanders, R. A. & Watkins, J. B., May 1 2003, In : Journal of Nutritional Biochemistry. 14, 5, p. 288-294 7 p.

Research output: Contribution to journalArticle

Thioctic Acid
Oxidative stress
Biomarkers
Streptozocin
Rats
80 Citations (Scopus)

EIF3 p170, a mediator of mimosine effect on protein synthesis and cell cycle progression

Dong, Z. & Zhang, J-T., Sep 1 2003, In : Molecular Biology of the Cell. 14, 9, p. 3942-3951 10 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-3
Mimosine
Cell Cycle Proteins
Protein Biosynthesis
Tubulin
35 Citations (Scopus)
Folic Acid Antagonists
Pyrimidines
Tetrahydrofolate Dehydrogenase
Pathogens
Acquired Immunodeficiency Syndrome
15 Citations (Scopus)
Toxoplasma
Pathogens
Plasmodium falciparum
Histones
Parasites
21 Citations (Scopus)

Molecular cloning and characterization of an SRCAP chromatin remodeling homologue in Toxoplasma gondii

Sullivan, W., Monroy, M. A., Bohne, W., Nallani, K. C., Chrivia, J., Yaciuk, P., Smith, C. K. & Queener, S., May 1 2003, In : Parasitology Research. 90, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Toxoplasma
Molecular Cloning
Toxoplasma gondii
chromatin
14 Citations (Scopus)

Oxidative Stress in Rats after 60 Days of Hypergalactosemia or Hyperglycemia

Otsyula, M., King, M. S., Ketcham, T. G., Sanders, R. A. & Watkins, J. B., Nov 2003, In : International Journal of Toxicology. 22, 6, p. 423-427 5 p.

Research output: Contribution to journalArticle

Oxidative stress
Hyperglycemia
Rats
Oxidative Stress
Streptozocin
266 Citations (Scopus)
Substance P
Neuropeptides
Protein Kinase C
Inflammation
Spinal Cord
17 Citations (Scopus)

Prostaglandin E2 inhibits the potassium current in sensory neurons from hyperalgesic Kv1.1 knockout mice

Jiang, X., Zhang, Y. H., Clark, J. D., Tempel, B. L. & Nicol, G., Jun 18 2003, In : Neuroscience. 119, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Dinoprostone
Knockout Mice
Potassium
Hot Temperature
298 Citations (Scopus)

Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)

Bhave, G., Hu, H. J., Glauner, K. S., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S. & Gereau IV, R. W., Oct 14 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 21, p. 12480-12485 6 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Protein Kinase C
Phosphorylation
Acetates
Capsaicin
52 Citations (Scopus)

Regulation of constitutive expression of mouse PTEN by the 5′-untranslated region

Han, B., Dong, Z., Liu, Y., Chen, Q., Hashimoto, K. & Zhang, J-T., Aug 14 2003, In : Oncogene. 22, 34, p. 5325-5337 13 p.

Research output: Contribution to journalArticle

5' Untranslated Regions
Messenger RNA
Firefly Luciferases
Neoplasms
Proto-Oncogene Proteins c-akt
16 Citations (Scopus)

Synaptic and membrane properties of neurons in the dorsomedial hypothalamus

Bailey, T. W., Nicol, G., Schild, J. H. & DiMicco, J. A., Sep 26 2003, In : Brain Research. 985, 2, p. 150-162 13 p.

Research output: Contribution to journalArticle

Synaptic Membranes
Hypothalamus
Paraventricular Hypothalamic Nucleus
Neurons
6-Cyano-7-nitroquinoxaline-2,3-dione
55 Citations (Scopus)
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
Cell culture
Antineoplastic Agents
42 Citations (Scopus)

Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3-d]pyrimidines

Donkor, I. O., Li, H. & Queener, S., Jun 1 2003, In : European Journal of Medicinal Chemistry. 38, 6, p. 605-611 7 p.

Research output: Contribution to journalArticle

Pyrimidines
Folic Acid Antagonists
Pneumocystis carinii
Mycobacterium avium
Toxoplasma
89 Citations (Scopus)
Pneumocystis carinii
Mycobacterium avium
Tetrahydrofolate Dehydrogenase
Toxoplasma
Quinazolines
18 Citations (Scopus)

Tight Control of Platelet-derived Growth Factor B/c-sis Expression by Interplay between the 5′-Untranslated Region Sequence and the Major Upstream Promoter

Han, B., Dong, Z. & Zhang, J-T., Nov 21 2003, In : Journal of Biological Chemistry. 278, 47, p. 46983-46993 11 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-sis
5' Untranslated Regions
Messenger RNA
Cells
Leukemia, Erythroblastic, Acute
28 Citations (Scopus)
Caspase 8
Caspases
Caspase 3
Reactive Oxygen Species
Leukemia
2002
356 Citations (Scopus)

Cellular mechanisms of neurogenic inflammation

Richardson, J. D. & Vasko, M., Sep 2002, In : Journal of Pharmacology and Experimental Therapeutics. 302, 3, p. 839-845 7 p.

Research output: Contribution to journalArticle

Neurogenic Inflammation
Sensory Receptor Cells
Critical Pathways
Calcitonin Gene-Related Peptide
Wounds and Injuries
130 Citations (Scopus)
Ceramides
Second Messenger Systems
Nerve Growth Factor
Sensory Receptor Cells
Sphingomyelin Phosphodiesterase
18 Citations (Scopus)

Cytoplasmic retraction of the amino terminus of human multidrug resistance protein 1

Chen, Q., Yang, Y., Liu, Y., Han, B. & Zhang, J-T., Jul 23 2002, In : Biochemistry. 41, 29, p. 9052-9062 11 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Epitopes
MDR Genes
Multiple Drug Resistance
Indirect Fluorescent Antibody Technique
49 Citations (Scopus)

Dimerization of human XPA and formation of XPA2-RPA protein complex

Yang, Z. G., Liu, Y., Mao, L. Y., Zhang, J-T. & Zou, Y., Oct 29 2002, In : Biochemistry. 41, 43, p. 13012-13020 9 p.

Research output: Contribution to journalArticle

Dimerization
Molecular mass
Dimers
Repair
Nucleotides
43 Citations (Scopus)

Effects of combined Quercetin and coenzyme Q10 treatment on oxidative stress in normal and diabetic rats

Coldiron, A. D., Sanders, R. A. & Watkins, J. B., 2002, In : Journal of Biochemical and Molecular Toxicology. 16, 4, p. 197-202 6 p.

Research output: Contribution to journalArticle

coenzyme Q10
Oxidative stress
Quercetin
Rats
Oxidative Stress
23 Citations (Scopus)

Effects of β-carotene on oxidative stress in normal and diabetic rats

Maritim, A., Dene, B. A., Sanders, R. A. & Watkins, J. B., 2002, In : Journal of Biochemical and Molecular Toxicology. 16, 4, p. 203-208 6 p.

Research output: Contribution to journalArticle

Oxidative stress
Carotenoids
Rats
Oxidative Stress
Medical problems
2 Citations (Scopus)

Inclusion of a competency-based curriculum in medical pharmacology

Near, J. A., Bosin, T. R. & Watkins, J. B., 2002, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 366, 1, p. 26-29 4 p.

Research output: Contribution to journalArticle

Curriculum
Pharmacology
Students
Educational Models
Foster Home Care
43 Citations (Scopus)
Pneumocystis carinii
Mycobacterium avium
Pyrimidines
Tetrahydrofolate Dehydrogenase
Trimethoprim
6 Citations (Scopus)

Mechanism of β2- microglobulin-induced apoptosis in the K562 leukemia cell line, defective in major histocompatibility class 1

Wu, C. H., Gordon, J. D., Zhong, X. & Safa, A., Sep 2002, In : Anticancer Research. 22, 5, p. 2613-2621 9 p.

Research output: Contribution to journalArticle

Histocompatibility
K562 Cells
Leukemia
Apoptosis
Cell Line
53 Citations (Scopus)

Mechanisms of the release of anterogradely transported neurotrophin-3 from axon terminals

Wang, X., Butowt, R., Vasko, M. & Von Bartheld, C. S., Feb 1 2002, In : Journal of Neuroscience. 22, 3, p. 931-945 15 p.

Research output: Contribution to journalArticle

Neurotrophin 3
Presynaptic Terminals
Nerve Growth Factors
R-SNARE Proteins
Calcium
14 Citations (Scopus)

Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant

Wu, C. H., Gordon, J., Rastegar, M., Ogretmen, B. & Safa, A., Aug 1 2002, In : Oncogene. 21, 33, p. 5160-5174 15 p.

Research output: Contribution to journalArticle

Myeloblastin
HL-60 Cells
Serine Proteases
Doxorubicin
Leukemia
94 Citations (Scopus)

Regulation of gene expression by internal ribosome entry sites or cryptic promoters: The eIF4G story

Han, B. & Zhang, J-T., Nov 2002, In : Molecular and Cellular Biology. 22, 21, p. 7372-7384 13 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
5' Untranslated Regions
Messenger RNA
Northern Blotting
Proto-Oncogene Proteins c-ets
44 Citations (Scopus)

Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1

Yang, Y., Chen, Q. & Zhang, J-T., Nov 15 2002, In : Journal of Biological Chemistry. 277, 46, p. 44268-44277 10 p.

Research output: Contribution to journalArticle

Cysteine
Leukotriene C4
Mutation
Membranes
multidrug resistance-associated protein 1
32 Citations (Scopus)

Structural studies on bioactive compounds. Part 36: Design, synthesis and biological evaluation of pyrimethamine-based antifolates against Pneumocystis carinii

Chan, D. C. M., Laughton, C. A., Queener, S. & Stevens, M. F. G., 2002, In : Bioorganic and Medicinal Chemistry. 10, 9, p. 3001-3010 10 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Pyrimethamine
Inhibitory Concentration 50
Derivatives
13 Citations (Scopus)

Twenty-four hour exposure to prostaglandin downregulates prostanoid receptor binding but does not alter PGE2-mediated sensitization of rat sensory neurons

Southall, M. D., Bolyard, L. A. & Vasko, M., 2002, In : Pain. 96, 3, p. 285-296 12 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Dinoprostone
Prostaglandins
Down-Regulation
Inflammation
2001
7 Citations (Scopus)

Changes in the kinetic parameters of hepatic γ-glutamyltransferase from streptozotocin-induced diabetic rats

Cornwell, P. D. & Watkins, J. B., Feb 9 2001, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1545, 1-2, p. 184-191 8 p.

Research output: Contribution to journalArticle

Streptozocin
Kinetic parameters
Rats
Rat control
Liver
8 Citations (Scopus)

Characterization of oxidative stress in various tissues of diabetic and galactose-fed rats

Strother, R. M., Thomas, T. G., Otsyula, M., Sanders, R. A. & Watkins, J. B., 2001, In : International Journal of Experimental Diabetes Research. 2, 3, p. 211-216 6 p.

Research output: Contribution to journalArticle

Galactose
Oxidative Stress
Liver
Kidney
Catalase
1 Citation (Scopus)

Conformationally restricted tricyclic analogues of lipophilic pyrido[2,3-d]pyrimidine antifolates [1a,b]

Gangjee, A., Mavandadi, F. & Queener, S., 2001, In : Journal of Heterocyclic Chemistry. 38, 1, p. 213-220 8 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Trimetrexate
Rats
Boranes
84 Citations (Scopus)

Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from pneumocystis carinii

Graffner-Nordberg, M., Kolmodin, K., Åqvist, J., Queener, S. & Hallberg, A., Jul 19 2001, In : Journal of Medicinal Chemistry. 44, 15, p. 2391-2402 12 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Esters
Trimetrexate
16 Citations (Scopus)

Differential splicing of Pneumocystis carinii f. sp. carinii inosine 5′-monophosphate dehydrogenase pre-mRNA

Ye, D., Lee, C-H. & Queener, S., Jan 24 2001, In : Gene. 263, 1-2, p. 151-158 8 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Pneumocystis carinii
RNA Precursors
Enzymes
Amino Acids
83 Citations (Scopus)

Effects of coenzyme Q10 treatment on antioxidant pathways in normal and streptozotocin-induced diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., 2001, In : Journal of Biochemical and Molecular Toxicology. 15, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

coenzyme Q10
Streptozocin
Rats
Medical problems
Antioxidants
41 Citations (Scopus)

Effects of isoeugenol on oxidative stress pathways in normal and streptozotocin-induced diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., 2001, In : Journal of Biochemical and Molecular Toxicology. 15, 3, p. 159-164 6 p.

Research output: Contribution to journalArticle

isoeugenol
Oxidative stress
Streptozocin
Rats
Oxidative Stress
121 Citations (Scopus)

Effects of Quercetin on antioxidant defense in streptozotocin-induced diabetic rats

Sanders, R. A., Rauscher, F. M. & Watkins, J. B., 2001, In : Journal of Biochemical and Molecular Toxicology. 15, 3, p. 143-149 7 p.

Research output: Contribution to journalArticle

Quercetin
Streptozocin
Rats
Antioxidants
Glutathione Disulfide
80 Citations (Scopus)

Identification of a 170-kDa protein over-expressed in lung cancers

Pincheira, R., Chen, Q. & Zhang, J-T., Jun 1 2001, In : British Journal of Cancer. 84, 11, p. 1520-1527 8 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Peptide Initiation Factors
Proteins
Growth and Development
Early Detection of Cancer
16 Citations (Scopus)

N,N′-Bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents

Huang, T. L., Tao, B., Quarshie, Y., Queener, S. & Donkor, I. O., Oct 22 2001, In : Bioorganic and Medicinal Chemistry Letters. 11, 20, p. 2679-2681 3 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Cell culture
DNA
Cell Culture Techniques
Growth
26 Citations (Scopus)

Phorbol ester-induced inhibition of potassium currents in rat sensory neurons requires voltage-dependent entry of calcium

Zhang, Y. H., Kenyon, J. L. & Nicol, G., 2001, In : Journal of Neurophysiology. 85, 1, p. 362-373 12 p.

Research output: Contribution to journalArticle

Phorbol Esters
Sensory Receptor Cells
Protein Kinase C
Potassium
Calcium
152 Citations (Scopus)

Prostaglandin Receptor Subtypes, EP3C and EP4, Mediate the Prostaglandin E2-induced cAMP Production and Sensitization of Sensory Neurons

Southall, M. D. & Vasko, M., May 11 2001, In : Journal of Biological Chemistry. 276, 19, p. 16083-16091 9 p.

Research output: Contribution to journalArticle

Receptors, Prostaglandin E, EP4 Subtype
Prostaglandin Receptors
Sensory Receptor Cells
Dinoprostone
Neurons
20 Citations (Scopus)
Pneumocystis carinii
Pyrimethamine
Tetrahydrofolate Dehydrogenase
Triazenes
Liver
68 Citations (Scopus)

Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines

Gangjee, A., Vidwans, A., Elzein, E., McGuire, J. J., Queener, S. & Kisliuk, R. L., Jun 7 2001, In : Journal of Medicinal Chemistry. 44, 12, p. 1993-2003 11 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Thymidylate Synthase
Pemetrexed
Inhibitory Concentration 50
38 Citations (Scopus)

Synthesis of 2,4-Diamino-6-(thioarylmethyl)pyrido[2,3-d]pyrimidines as dihydrofolate reductase inhibitors

Gangjee, A., Adair, O. & Queener, S., 2001, In : Bioorganic and Medicinal Chemistry. 9, 11, p. 2929-2935 7 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Pneumocystis carinii
Pyrimidines
Toxoplasma
13 Citations (Scopus)
MDR Genes
P-Glycoprotein
Glycoproteins
Multiple Drug Resistance
Adenosine Triphosphate
29 Citations (Scopus)

Two subcellular localizations of eIF3 p170 and its interaction with membrane-bound microfilaments: Implications for alternative functions of p170

Pincheira, R., Chen, Q., Huang, Z. & Zhang, J-T., 2001, In : European Journal of Cell Biology. 80, 6, p. 410-418 9 p.

Research output: Contribution to journalArticle

Prokaryotic Initiation Factor-3
Eukaryotic Initiation Factor-3
Eukaryotic Initiation Factors
Actin Cytoskeleton
Membranes
23 Citations (Scopus)

β2-microglobulin induces apoptosis in HL-60 human leukemia cell line and its multidrug resistant variants overexpressing MRP1 but lacking Bax or overexpressing P-glycoprotein

Wu, C. H., Rastegar, M., Gordon, J. & Safa, A., Oct 25 2001, In : Oncogene. 20, 48, p. 7006-7020 15 p.

Research output: Contribution to journalArticle

HL-60 Cells
P-Glycoprotein
Leukemia
Apoptosis
Cell Line
2000
70 Citations (Scopus)

Design, synthesis, and x-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent

Gangjee, A., Yu, J., McGuire, J. J., Cody, V., Galitsky, N., Kisliuk, R. L. & Queener, S., Oct 19 2000, In : Journal of Medicinal Chemistry. 43, 21, p. 3837-3851 15 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Methotrexate
Antineoplastic Agents
Crystal structure
Cells