Pharmacology & Toxicology

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2001

Changes in the kinetic parameters of hepatic γ-glutamyltransferase from streptozotocin-induced diabetic rats

Cornwell, P. D. & Watkins, J. B., Feb 9 2001, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1545, 1-2, p. 184-191 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Characterization of oxidative stress in various tissues of diabetic and galactose-fed rats

Strother, R. M., Thomas, T. G., Otsyula, M., Sanders, R. A. & Watkins, J. B., Jan 1 2001, In : International Journal of Experimental Diabetes Research. 2, 3, p. 211-216 6 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Conformationally restricted tricyclic analogues of lipophilic pyrido[2, 3-d]pyrimidine antifolates [1a, b]

Gangjee, A., Mavandadi, F. & Queener, S. F., Jan 1 2001, In : Journal of Heterocyclic Chemistry. 38, 1, p. 213-220 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from pneumocystis carinii

Graffner-Nordberg, M., Kolmodin, K., Åqvist, J., Queener, S. F. & Hallberg, A., Jul 19 2001, In : Journal of Medicinal Chemistry. 44, 15, p. 2391-2402 12 p.

Research output: Contribution to journalArticle

84 Scopus citations

Differential splicing of Pneumocystis carinii f. sp. carinii inosine 5′-monophosphate dehydrogenase pre-mRNA

Ye, D., Lee, C. H. & Queener, S. F., Jan 24 2001, In : Gene. 263, 1-2, p. 151-158 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Effects of coenzyme Q10 treatment on antioxidant pathways in normal and streptozotocin-induced diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., Feb 19 2001, In : Journal of Biochemical and Molecular Toxicology. 15, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

85 Scopus citations

Effects of isoeugenol on oxidative stress pathways in normal and streptozotocin-induced diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., Jun 19 2001, In : Journal of Biochemical and Molecular Toxicology. 15, 3, p. 159-164 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Effects of Quercetin on antioxidant defense in streptozotocin-induced diabetic rats

Sanders, R. A., Rauscher, F. M. & Watkins, J. B., Jun 19 2001, In : Journal of Biochemical and Molecular Toxicology. 15, 3, p. 143-149 7 p.

Research output: Contribution to journalArticle

122 Scopus citations

Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation

Kuzhikandathil, E. V., Wang, H., Szabo, T., Morozova, N., Blumberg, P. M. & Oxford, G. S., Nov 15 2001, In : Journal of Neuroscience. 21, 22, p. 8697-8706 10 p.

Research output: Contribution to journalArticle

103 Scopus citations

Identification of a 170-kDa protein over-expressed in lung cancers

Pincheira, R., Chen, Q. & Zhang, J. T., Jun 1 2001, In : British Journal of Cancer. 84, 11, p. 1520-1527 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Impact of the basic amine on the biological activity and intracellular distribution of an aza-anthrapyrazole: BBR 3422

Chou, K. M., Paul Krapcho, A. & Hacker, M. P., Dec 15 2001, In : Biochemical Pharmacology. 62, 10, p. 1337-1343 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

N,N′-Bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents

Huang, T. L., Tao, B., Quarshie, Y., Queener, S. F. & Donkor, I. O., Oct 22 2001, In : Bioorganic and Medicinal Chemistry Letters. 11, 20, p. 2679-2681 3 p.

Research output: Contribution to journalArticle

17 Scopus citations

Phorbol ester-induced inhibition of potassium currents in rat sensory neurons requires voltage-dependent entry of calcium

Zhang, Y. H., Kenyon, J. L. & Nicol, G. D., Jan 31 2001, In : Journal of Neurophysiology. 85, 1, p. 362-373 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
154 Scopus citations
20 Scopus citations

Sucrase-isomaltase: An epithelial chloride channel? [1] (multiple letters)

Danielsen, E. M., Sjöström, H., Norén, O., Danielsen, G. M., Finn, A. L. & Oxford, G. S., Jan 1 2001, In : Gastroenterology. 121, 3, p. 741-742 2 p.

Research output: Contribution to journalArticle

Sucrase-isomaltase is and adenosine 3′, 5′-cyclic monophosphate-dependent epithelial chloride channel

Finn, A. L., Kuzhikandathil, E. V., Oxford, G. S. & Itoh-Lindstrom, Y., Jan 2001, In : Gastroenterology. 120, 1, p. 117-125 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines

Gangjee, A., Vidwans, A., Elzein, E., McGuire, J. J., Queener, S. F. & Kisliuk, R. L., Jun 7 2001, In : Journal of Medicinal Chemistry. 44, 12, p. 1993-2003 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

Synthesis of 2,4-Diamino-6-(thioarylmethyl)pyrido[2,3-d]pyrimidines as dihydrofolate reductase inhibitors

Gangjee, A., Adair, O. & Queener, S. F., Oct 9 2001, In : Bioorganic and Medicinal Chemistry. 9, 11, p. 2929-2935 7 p.

Research output: Contribution to journalArticle

38 Scopus citations
13 Scopus citations

Two subcellular localizations of eIF3 p170 and its interaction with membrane-bound microfilaments: Implications for alternative functions of p170

Pincheira, R., Chen, Q., Huang, Z. & Zhang, J. T., Jan 1 2001, In : European Journal of Cell Biology. 80, 6, p. 410-418 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

β2-microglobulin induces apoptosis in HL-60 human leukemia cell line and its multidrug resistant variants overexpressing MRP1 but lacking Bax or overexpressing P-glycoprotein

Wu, C. H., Rastegar, M., Gordon, J. & Safa, A. R., Oct 25 2001, In : Oncogene. 20, 48, p. 7006-7020 15 p.

Research output: Contribution to journalArticle

24 Scopus citations
2000

A double mutation in families with periodic paralysis defines new aspects of sodium channel slow inactivation

Bendahhou, S., Cummins, T. R., Hahn, A. F., Langlois, S., Waxman, S. G. & Ptácek, L. J., Jan 1 2000, In : Journal of Clinical Investigation. 106, 3, p. 431-438 8 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

A novel action of human apurinic/apyrimidinic endonuclease. Excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA

Chou, K. M., Kukhanova, M. & Cheng, Y. C., Oct 6 2000, In : Journal of Biological Chemistry. 275, 40, p. 31009-31015 7 p.

Research output: Contribution to journalArticle

Open Access
103 Scopus citations

Characterization and regulation of E2F activity during Caco-2 cell differentiation

Ding, Q., Wang, Q., Dong, Z. & Evers, B. M., Feb 29 2000, In : American Journal of Physiology - Cell Physiology. 278, 1 47-1, p. C110-C117

Research output: Contribution to journalArticle

7 Scopus citations

Design, synthesis, and x-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent

Gangjee, A., Yu, J., McGuire, J. J., Cody, V., Galitsky, N., Kisliuk, R. L. & Queener, S. F., Oct 19 2000, In : Journal of Medicinal Chemistry. 43, 21, p. 3837-3851 15 p.

Research output: Contribution to journalArticle

73 Scopus citations

Determinant of the extracellular location of the N-terminus of human multidrug-resistance-associated protein

Zhang, J. T., Jun 15 2000, In : Biochemical Journal. 348, 3, p. 597-606 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Dominant-negative mutants identify a role for GIRK channels in D3 dopamine receptor-mediated regulation of spontaneous secretory activity

Kuzhikandathil, E. V. & Oxford, G. S., Jun 1 2000, In : Journal of General Physiology. 115, 6, p. 697-706 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Downregulation of mitogen-activated protein kinases in human colon cancers

Wang, Q., Ding, Q., Dong, Z., Ehlers, R. A. & Evers, B. M., Apr 18 2000, In : Anticancer Research. 20, 1 A, p. 75-83 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Dual responses of CNS mitochondria to elevated calcium

Brustovetsky, N. & Dubinsky, J. M., Jan 1 2000, In : Journal of Neuroscience. 20, 1, p. 103-113 11 p.

Research output: Contribution to journalArticle

Open Access
115 Scopus citations

Effect of melatonin on phase I and II biotransformation enzymes in streptozotocin-induced diabetic rats

Maritim, A. C., Moore, B. H., Sanders, R. A. & Watkins, J. B., Jan 1 2000, In : International Journal of Toxicology. 19, 4, p. 277-283 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effects of aldose reductase inhibitors on antioxidant defense in rat and rabbit liver

Thomas, T., Rauscher, F., Sanders, R., Veltman, J. & Watkins, J. B., Jan 1 2000, In : Toxicological Sciences. 53, 1, p. 145-149 5 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Effects of new antioxidant compounds PNU-104067F and PNU-74389G on antioxidant defense in normal and diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., Dec 1 2000, In : Journal of Biochemical and Molecular Toxicology. 14, 4, p. 189-194 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., Jan 1 2000, In : Journal of Biochemical and Molecular Toxicology. 14, 6, p. 329-334 6 p.

Research output: Contribution to journalArticle

73 Scopus citations
46 Scopus citations
18 Scopus citations

Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons

Evans, A. R., Junger, H., Southall, M. D., Nicol, G. D., Sorkin, L. S., Broome, J. T., Bailey, T. W. & Vasko, M. R., Jun 1 2000, In : Journal of Pharmacology and Experimental Therapeutics. 293, 3, p. 912-920 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Prostaglandin E2-mediated sensitization of rat sensory neurons is not altered by nerve growth factor

Southall, M. D. & Vasko, M. R., Jun 16 2000, In : Neuroscience Letters. 287, 1, p. 33-36 4 p.

Research output: Contribution to journalArticle

30 Scopus citations

Role of ribosome in sequence-specific regulation of membrane targeting and translocation of P-glycoprotein signal-anchor transmembrane segments

Zhang, J. T., Han, E. & Liu, Y., Aug 15 2000, In : Journal of cell science. 113, 14, p. 2545-2555 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Selective inhibitors of Pneumocystis carinii dihydrofolate reductase via structure-based design

Chan, D., Stevens, M. F. G., Laughton, C. A., Cody, V., Galitsky, N., Rak, D., Luft, J. R., Pangborn, W. & Queener, S. F., Dec 1 2000, In : Journal of Pharmacy and Pharmacology. 52, 9 SUPPL., 1 p.

Research output: Contribution to journalArticle

Sensitization of rat sensory neurons by chronic exposure to forskolin or 'inflammatory cocktail' does not downregulate and requires continuous exposure

Bolyard, L. A., Van Looy, J. W. & Vasko, M. R., Dec 1 2000, In : Pain. 88, 3, p. 277-285 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Site-specific DNA methylation contributes to neurotensin/neuromedin N expression in colon cancers

Dong, Z., Wang, X. & Evers, B. M., Jan 1 2000, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 279, 6 42-6, p. G1139-G1147

Research output: Contribution to journalArticle

24 Scopus citations

Streptozotocin and insulin-dependent diabetes induce changes in hepatic cytoarchitecture in mice

Watkins, J. B., Gardner, P. A., Feczko, J. D. & Klueber, K. M., Jan 1 2000, In : International Journal of Toxicology. 19, 6, p. 401-405 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate

Cody, V., Chan, D., Galitsky, N., Rak, D., Luft, J. R., Pangborn, W., Queener, S. F., Laughton, C. A. & Stevens, M. F. G., Apr 4 2000, In : Biochemistry. 39, 13, p. 3556-3564 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
14 Scopus citations

Voltage-dependent ion channels in CAD cells: A catecholaminergic neuronal line that exhibits inducible differentiation

Wang, H. & Oxford, G. S., Dec 27 2000, In : Journal of Neurophysiology. 84, 6, p. 2888-2895 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
1999

Activation and inactivation of the voltage-gated sodium channel: Role of segment S5 revealed by a novel hyperkalaemic periodic paralysis mutation

Bendahhou, S., Cummins, T. R., Tawil, R., Waxman, S. G. & Ptácek, L. J., Jun 15 1999, In : Journal of Neuroscience. 19, 12, p. 4762-4771 10 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

Activation of human D3 dopamine receptor inhibits P/Q-type calcium channels and secretory activity in AtT-20 cells

Kuzhikandathil, E. V. & Oxford, G. S., Mar 1 1999, In : Journal of Neuroscience. 19, 5, p. 1698-1707 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Activation of protein kinase C enhances peptide release from rat spinal cord slices

Frayer, S. M., Barber, L. A. & Vasko, M. R., Apr 9 1999, In : Neuroscience Letters. 265, 1, p. 17-20 4 p.

Research output: Contribution to journalArticle

17 Scopus citations