Pharmacology & Toxicology

Publications 1971 2020

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2000
11 Citations (Scopus)

Determinant of the extracellular location of the N-terminus of human multidrug-resistance-associated protein

Zhang, J-T., Jun 15 2000, In : Biochemical Journal. 348, 3, p. 597-606 10 p.

Research output: Contribution to journalArticle

Multidrug Resistance-Associated Proteins
Membranes
Protein Folding
Adenosine Triphosphate
Signal Recognition Particle
3 Citations (Scopus)

Effect of melatonin on phase I and II biotransformation enzymes in streptozotocin-induced diabetic rats

Maritim, A. C., Moore, B. H., Sanders, R. A. & Watkins, J. B., 2000, In : International Journal of Toxicology. 19, 4, p. 277-283 7 p.

Research output: Contribution to journalArticle

Melatonin
Streptozocin
Biotransformation
Rats
Liver
11 Citations (Scopus)

Effects of aldose reductase inhibitors on antioxidant defense in rat and rabbit liver

Thomas, T., Rauscher, F., Sanders, R., Veltman, J. & Watkins, J. B., 2000, In : Toxicological Sciences. 53, 1, p. 145-149 5 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Liver
Rats
Antioxidants
Glutathione Reductase
22 Citations (Scopus)

Effects of new antioxidant compounds PNU-104067F and PNU-74389G on antioxidant defense in normal and diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., 2000, In : Journal of Biochemical and Molecular Toxicology. 14, 4, p. 189-194 6 p.

Research output: Contribution to journalArticle

Rats
Medical problems
Antioxidants
Glutathione Peroxidase
Lipid Peroxidation
72 Citations (Scopus)

Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., 2000, In : Journal of Biochemical and Molecular Toxicology. 14, 6, p. 329-334 6 p.

Research output: Contribution to journalArticle

piperine
Streptozocin
Glutathione Disulfide
Rats
Medical problems
46 Citations (Scopus)
Videocassette recorders
HL-60 Cells
Myeloid Cells
Acute Myeloid Leukemia
Luciferases
18 Citations (Scopus)
Multidrug Resistance-Associated Proteins
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Messenger RNA
Acute Myeloid Leukemia
Biphenotypic Acute Leukemia
49 Citations (Scopus)

Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons

Evans, A. R., Junger, H., Southall, M. D., Nicol, G., Sorkin, L. S., Broome, J. T., Bailey, T. W. & Vasko, M., Jun 2000, In : Journal of Pharmacology and Experimental Therapeutics. 293, 3, p. 912-920 9 p.

Research output: Contribution to journalArticle

Isoprostanes
Nociception
Eicosanoids
Sensory Receptor Cells
Dinoprostone
30 Citations (Scopus)

Prostaglandin E2-mediated sensitization of rat sensory neurons is not altered by nerve growth factor

Southall, M. D. & Vasko, M., Jun 16 2000, In : Neuroscience Letters. 287, 1, p. 33-36 4 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Sensory Receptor Cells
Dinoprostone
Calcitonin Gene-Related Peptide
Neurons
4 Citations (Scopus)

Role of ribosome in sequence-specific regulation of membrane targeting and translocation of P-glycoprotein signal-anchor transmembrane segments

Zhang, J-T., Han, E. & Liu, Y., 2000, In : Journal of Cell Science. 113, 14, p. 2545-2555 11 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Ribosomes
Membranes
Reticulocytes
Triticum

Selective inhibitors of Pneumocystis carinii dihydrofolate reductase via structure-based design

Chan, D., Stevens, M. F. G., Laughton, C. A., Cody, V., Galitsky, N., Rak, D., Luft, J. R., Pangborn, W. & Queener, S., 2000, In : Journal of Pharmacy and Pharmacology. 52, 9 SUPPL., p. 226 1 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
23 Citations (Scopus)

Sensitization of rat sensory neurons by chronic exposure to forskolin or 'inflammatory cocktail' does not downregulate and requires continuous exposure

Bolyard, L. A., Van Looy, J. W. & Vasko, M., Dec 1 2000, In : Pain. 88, 3, p. 277-285 9 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Colforsin
Down-Regulation
Bradykinin
Potassium
4 Citations (Scopus)

Streptozotocin and insulin-dependent diabetes induce changes in hepatic cytoarchitecture in mice

Watkins, J. B., Gardner, P. A., Feczko, J. D. & Klueber, K. M., 2000, In : International Journal of Toxicology. 19, 6, p. 401-405 5 p.

Research output: Contribution to journalArticle

Streptozocin
Medical problems
Liver
Insulin
Microvilli
23 Citations (Scopus)

Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate

Cody, V., Chan, D., Galitsky, N., Rak, D., Luft, J. R., Pangborn, W., Queener, S., Laughton, C. A. & Stevens, M. F. G., Apr 4 2000, In : Biochemistry. 39, 13, p. 3556-3564 9 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Molecular modeling
Molecular Structure
14 Citations (Scopus)
Folic Acid Antagonists
Pyrimidines
Tetrahydrofolate Dehydrogenase
Substitution reactions
Liver
1999
17 Citations (Scopus)

Activation of protein kinase C enhances peptide release from rat spinal cord slices

Frayer, S. M., Barber, L. A. & Vasko, M., Apr 9 1999, In : Neuroscience Letters. 265, 1, p. 17-20 4 p.

Research output: Contribution to journalArticle

Phorbol 12,13-Dibutyrate
Protein Kinase C
Spinal Cord
Peptides
Capsaicin
31 Citations (Scopus)

Decreased apoptosis as a mechanism for hepatomegaly in streptozotocin- induced diabetic rats

Herrman, C. E., Sanders, R. A., Klaunig, J. E., Schwarz, L. R. & Watkins, J. B., 1999, In : Toxicological Sciences. 50, 1, p. 146-151 6 p.

Research output: Contribution to journalArticle

Hepatomegaly
Streptozocin
Rats
Medical problems
Liver
28 Citations (Scopus)

Effects of melatonin on oxidative stress in streptozotocin-induced diabetic rats

Maritim, A. C., Moore, B. H., Sanders, R. A. & Watkins, J. B., May 1999, In : International Journal of Toxicology. 18, 3, p. 161-166 6 p.

Research output: Contribution to journalArticle

Oxidative stress
Melatonin
Streptozocin
Rats
Oxidative Stress
10 Citations (Scopus)
Pneumocystis carinii
Pyrimethamine
Tetrahydrofolate Dehydrogenase
Toxoplasma
Carbon
65 Citations (Scopus)

Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+

Cody, V., Galitsky, N., Rak, D., Luft, J. R., Pangborn, W. & Queener, S., Apr 6 1999, In : Biochemistry. 38, 14, p. 4303-4312 10 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
NADP
Folic Acid
Crystal structure
2 Citations (Scopus)

Membrane orientation of carboxyl-terminal half P-glycoprotein: Topogenesis of transmembrane segments

Han, E. S. & Zhang, J-T., 1999, In : European Journal of Cell Biology. 78, 9, p. 624-631 8 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Protein Sorting Signals
Membranes
Cell-Free System
Endoplasmic Reticulum
14 Citations (Scopus)

One-step synthesis of novel 2,4-diaminopyrimidine antifolates from bridged alicyclic ketones and cyanoguanidine

Rosowsky, A., Papoulis, A. T. & Queener, S., May 1999, In : Journal of Heterocyclic Chemistry. 36, 3, p. 723-728 6 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Ketones
Carbon
Tetrahydrofolate Dehydrogenase
Trimethoprim
9 Citations (Scopus)
Multiple Drug Resistance
P-Glycoprotein
Binding Sites
P-Glycoproteins
Pharmaceutical Preparations
101 Citations (Scopus)
Folic Acid Antagonists
Pneumocystis carinii
Methylation
Toxoplasma
Bioactivity
50 Citations (Scopus)

Structure-based design of selective inhibitors of dihydrofolate reductase: Synthesis and antiparasitic activity of 2,4-diaminopteridine analogues with a bridged diarylamine side chain

Rosowsky, A., Cody, V., Galitsky, N., Fu, H., Papoulis, A. T. & Queener, S., 1999, In : Journal of Medicinal Chemistry. 42, 23, p. 4853-4860 8 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Antiparasitic Agents
Pneumocystis carinii
Inhibitory Concentration 50
Toxoplasma
43 Citations (Scopus)

Synergistic effect of gemcitabine and irinotecan (CPT-11) on breast and small cell lung cancer cell lines

Bahadori, H. R., Rocha Lima, C. M. S., Green, M. R. & Safa, A., Nov 1999, In : Anticancer Research. 19, 6 B, p. 5423-5428 6 p.

Research output: Contribution to journalArticle

irinotecan
gemcitabine
Small Cell Lung Carcinoma
Breast
Cell Line
49 Citations (Scopus)

Synthesis and antiparasitic and antitumor activity of 2,4-diamino-6- (arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim

Rosowsky, A., Papoulis, A. T., Forsch, R. A. & Queener, S., Mar 25 1999, In : Journal of Medicinal Chemistry. 42, 6, p. 1007-1017 11 p.

Research output: Contribution to journalArticle

Antiparasitic Agents
Tetrahydrofolate Dehydrogenase
Inhibitory Concentration 50
Rats
Cells
36 Citations (Scopus)

Synthesis and anti-Pneumocystis carinii activity of conformationally restricted analogues of pentamidine

Tao, B., Huang, T. L., Zhang, Q., Jackson, L., Queener, S. & Donkor, I. O., Jun 1999, In : European Journal of Medicinal Chemistry. 34, 6, p. 531-538 8 p.

Research output: Contribution to journalArticle

Pentamidine
Pneumocystis carinii
Poly dA-dT
Denaturation
DNA
19 Citations (Scopus)

Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5- substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase

Gangjee, A., Mavandadi, F., Kisliuk, R. L. & Queener, S., Jun 17 1999, In : Journal of Medicinal Chemistry. 42, 12, p. 2272-2279 8 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Thymidylate Synthase
Quinazolines
Amines
Mannich Bases
87 Citations (Scopus)

The cAMP transduction cascade mediates the PGE2-induced inhibition of potassium currents in rat sensory neurones

Evans, A. R., Vasko, M. & Nicol, G., Apr 1 1999, In : Journal of Physiology. 516, 1, p. 163-178 16 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Dinoprostone
Cyclic AMP
Potassium
4-Aminopyridine
20 Citations (Scopus)

Topogenesis of cystic fibrosis transmembrane conductance regulator (CFTR): Regulation by the amino terminal transmembrane sequences

Chen, M. & Zhang, J-T., Apr 27 1999, In : Biochemistry. 38, 17, p. 5471-5477 7 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Membranes
Die casting inserts
Cell-Free System
Cystic Fibrosis
1998
28 Citations (Scopus)
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Trimethoprim
Toxoplasma
Liver
43 Citations (Scopus)
Bridged-Ring Compounds
Folic Acid Antagonists
Pneumocystis carinii
Toxoplasma
Tetrahydrofolate Dehydrogenase
57 Citations (Scopus)

Dissection of drug-binding-induced conformational changes in P-glycoprotein

Wang, G., Pincheira, R. & Zhang, J-T., Jul 15 1998, In : European Journal of Biochemistry. 255, 2, p. 383-390 8 p.

Research output: Contribution to journalArticle

Dissection
P-Glycoprotein
Pharmaceutical Preparations
Vinblastine
Conformations
1 Citation (Scopus)

Effects of aldose reductase inhibitors, AL-4114 and AL-1576, on hepatic biotransformation in rabbit and rat

Veltman, J. C., Kumar, A., Sanders, R. A. & Watkins, J. B., Nov 1998, In : International Journal of Toxicology. 17, 6, p. 603-617 15 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Biotransformation
Rats
Glucuronosyltransferase
Rabbits
72 Citations (Scopus)

Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices

Southall, M. D., Michael, R. L. & Vasko, M., Oct 1998, In : Pain. 78, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

Neuropeptides
Spinal Cord
Anti-Inflammatory Agents
Inflammation
Pharmaceutical Preparations
12 Citations (Scopus)

Mechanism involved in generating the carboxyl-terminal half topology of P-glycoprotein

Han, E. S. & Zhang, J-T., Aug 25 1998, In : Biochemistry. 37, 34, p. 11996-12004 9 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Anchors
Protein Sorting Signals
Topology
Membranes
49 Citations (Scopus)

Selective Pneumocystis carinii dihydrofolate reductase inhibitors: Design, synthesis, and biological evaluation of new 2,4-diamino-5- substituted-furo[2,3-d]pyrimidines

Gangjee, A., Guo, X., Queener, S., Cody, V., Galitsky, N., Luft, J. R. & Pangborn, W., Apr 9 1998, In : Journal of Medicinal Chemistry. 41, 8, p. 1263-1271 9 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Pyrimidines
Tetrahydrofolate Dehydrogenase
Naphthols
11 Citations (Scopus)

Streptozotocin-Induced Diabetes Increases γ-Glutamyltranspeptidase Activity but not Expression in Rat Liver

Watkins, J. B., Klaunig, J. E., Smith, H. M., Cornwell, P. & Sanders, R. A., 1998, In : Journal of Biochemical and Molecular Toxicology. 12, 4, p. 219-225 7 p.

Research output: Contribution to journalArticle

Experimental Diabetes Mellitus
Streptozocin
Medical problems
Liver
Rats
3 Citations (Scopus)

Streptozotocin May Provide Protection against Subsequent Oxidative Stress of Endotoxin or Streptozotocin in Rats

Omar, H. M., Rosenblum, J. K., Sanders, R. A. & Watkins, J. B., 1998, In : Journal of Biochemical and Molecular Toxicology. 12, 3, p. 143-149 7 p.

Research output: Contribution to journalArticle

Oxidative stress
Streptozocin
Endotoxins
Rats
Oxidative Stress
54 Citations (Scopus)

Structure-based design and synthesis of lipophilic 2,4-diamino-6- substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents

Gangjee, A., Vidwans, A. P., Vasudevan, A., Queener, S., Kisliuk, R. L., Cody, V., Li, R., Galitsky, N., Luft, J. R. & Pangborn, W., Aug 27 1998, In : Journal of Medicinal Chemistry. 41, 18, p. 3426-3434 9 p.

Research output: Contribution to journalArticle

Quinazolines
Folic Acid Antagonists
Growth Inhibitors
Tetrahydrofolate Dehydrogenase
Toxoplasma
32 Citations (Scopus)
Folic Acid Antagonists
Pyrimidines
Bioactivity
Tetrahydrofolate Dehydrogenase
Mycobacterium avium
240 Citations (Scopus)
Capsaicin
Sensory Receptor Cells
Dinoprostone
Colforsin
Cyclic AMP-Dependent Protein Kinases
3 Citations (Scopus)

Venipuncture in the medical physiology laboratory

Martin, B. J., Watkins, J. B. & Ramsey, J., 1998, In : The American journal of physiology. 274, 6 PART 2

Research output: Contribution to journalArticle

Phlebotomy
Students
Medical Education
Nutritional Physiological Phenomena
Medical Students
1997
42 Citations (Scopus)

2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Rosowsky, A., Papoulis, A. T. & Queener, S., 1997, In : Journal of Medicinal Chemistry. 40, 22, p. 3694-3699 6 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
Inhibitory Concentration 50
67 Citations (Scopus)

Activation and recovery of the PGE2-mediated sensitization of the capsaicin response in rat sensory neurons

Lopshire, J. C. & Nicol, G., Dec 1997, In : Journal of Neurophysiology. 78, 6, p. 3154-3164 11 p.

Research output: Contribution to journalArticle

Capsaicin
Sensory Receptor Cells
Dinoprostone
Cyclic GMP
Protein Kinases

Animation of intestinal absorption, enterohepatic circulation and intestinal and renal elimination

Watkins, J. B., 1997, In : FASEB Journal. 11, 3

Research output: Contribution to journalArticle

Enterohepatic Circulation
intestinal absorption
Intestinal Absorption
Animation
students
44 Citations (Scopus)

Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate

Cody, V., Galitsky, N., Luft, J. R., Pangborn, W., Gangjee, A., Devraj, R., Queener, S. & Blakley, R. L., 1997, In : Acta Crystallographica Section D: Biological Crystallography. 53, 6, p. 638-649 12 p.

Research output: Contribution to journalArticle

coenzymes
Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Coenzymes
48 Citations (Scopus)
Folic Acid Antagonists
Pneumocystis carinii
Purines
Trimethoprim
Toxoplasma