Pharmacology & Toxicology

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2000

Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons

Evans, A. R., Junger, H., Southall, M. D., Nicol, G. D., Sorkin, L. S., Broome, J. T., Bailey, T. W. & Vasko, M. R., Jun 1 2000, In : Journal of Pharmacology and Experimental Therapeutics. 293, 3, p. 912-920 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Limitations of cyclosporin A inhibition of the permeability transition in CNS mitochondria

Brustovetsky, N. & Dubinsky, J. M., Nov 15 2000, In : Journal of Neuroscience. 20, 22, p. 8229-8237 9 p.

Research output: Contribution to journalArticle

Open Access
142 Scopus citations

Nitric oxide is an autocrine regulator of Na+ currents in axotomized C- type DRG neurons

Renganathan, M., Cummins, T. R., Hormuzdiar, W. N., Black, J. A. & Waxman, S. G., 2000, In : Journal of Neurophysiology. 83, 4, p. 2431-2442 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Prostaglandin E2-mediated sensitization of rat sensory neurons is not altered by nerve growth factor

Southall, M. D. & Vasko, M. R., Jun 16 2000, In : Neuroscience Letters. 287, 1, p. 33-36 4 p.

Research output: Contribution to journalArticle

30 Scopus citations

Role of ribosome in sequence-specific regulation of membrane targeting and translocation of P-glycoprotein signal-anchor transmembrane segments

Zhang, J. T., Han, E. & Liu, Y., Aug 15 2000, In : Journal of cell science. 113, 14, p. 2545-2555 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Selective inhibitors of Pneumocystis carinii dihydrofolate reductase via structure-based design

Chan, D., Stevens, M. F. G., Laughton, C. A., Cody, V., Galitsky, N., Rak, D., Luft, J. R., Pangborn, W. & Queener, S. F., Dec 1 2000, In : Journal of Pharmacy and Pharmacology. 52, 9 SUPPL., 1 p.

Research output: Contribution to journalArticle

Sensitization of rat sensory neurons by chronic exposure to forskolin or 'inflammatory cocktail' does not downregulate and requires continuous exposure

Bolyard, L. A., Van Looy, J. W. & Vasko, M. R., Dec 1 2000, In : Pain. 88, 3, p. 277-285 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Site-specific DNA methylation contributes to neurotensin/neuromedin N expression in colon cancers

Dong, Z., Wang, X. & Evers, B. M., Jan 1 2000, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 279, 6 42-6, p. G1139-G1147

Research output: Contribution to journalArticle

24 Scopus citations

Streptozotocin and insulin-dependent diabetes induce changes in hepatic cytoarchitecture in mice

Watkins, J. B., Gardner, P. A., Feczko, J. D. & Klueber, K. M., Jan 1 2000, In : International Journal of Toxicology. 19, 6, p. 401-405 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate

Cody, V., Chan, D., Galitsky, N., Rak, D., Luft, J. R., Pangborn, W., Queener, S. F., Laughton, C. A. & Stevens, M. F. G., Apr 4 2000, In : Biochemistry. 39, 13, p. 3556-3564 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
14 Scopus citations

Voltage-dependent ion channels in CAD cells: A catecholaminergic neuronal line that exhibits inducible differentiation

Wang, H. & Oxford, G. S., Dec 27 2000, In : Journal of Neurophysiology. 84, 6, p. 2888-2895 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
1999

Activation and inactivation of the voltage-gated sodium channel: Role of segment S5 revealed by a novel hyperkalaemic periodic paralysis mutation

Bendahhou, S., Cummins, T. R., Tawil, R., Waxman, S. G. & Ptácek, L. J., Jun 15 1999, In : Journal of Neuroscience. 19, 12, p. 4762-4771 10 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

Activation of human D3 dopamine receptor inhibits P/Q-type calcium channels and secretory activity in AtT-20 cells

Kuzhikandathil, E. V. & Oxford, G. S., Mar 1 1999, In : Journal of Neuroscience. 19, 5, p. 1698-1707 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Activation of protein kinase C enhances peptide release from rat spinal cord slices

Frayer, S. M., Barber, L. A. & Vasko, M. R., Apr 9 1999, In : Neuroscience Letters. 265, 1, p. 17-20 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons.

Cummins, T. R., Dib-Hajj, S. D., Black, J. A., Akopian, A. N., Wood, J. N. & Waxman, S. G., Dec 15 1999, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 19, 24, p. RC43

Research output: Contribution to journalArticle

Open Access
321 Scopus citations

Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein

Smith, F. D., Oxford, G. S. & Milgram, S. L., Jul 9 1999, In : Journal of Biological Chemistry. 274, 28, p. 19894-19900 7 p.

Research output: Contribution to journalArticle

167 Scopus citations

CS3 fimbriae of enterotoxigenic Escherichia coli as chimeric expression carriers of heterologous antigenic determinants

Dong, Z., Zhang, Z., Li, S., Zhang, P. & Huang, C., Jan 1 1999, In : Science in China, Series C: Life Sciences. 42, 2, p. 128-135 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Decreased apoptosis as a mechanism for hepatomegaly in streptozotocin- induced diabetic rats

Herrman, C. E., Sanders, R. A., Klaunig, J. E., Schwarz, L. R. & Watkins, J. B., Aug 2 1999, In : Toxicological Sciences. 50, 1, p. 146-151 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Effects of melatonin on oxidative stress in streptozotocin-induced diabetic rats

Maritim, A. C., Moore, B. H., Sanders, R. A. & Watkins, J. B., May 1 1999, In : International Journal of Toxicology. 18, 3, p. 161-166 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Gonadal steroids in the treatment of mood disorders

Epperson, C. N., Wisner, K. L. & Yamamoto, B., 1999, In : Psychosomatic Medicine. 61, 5, p. 676-697 22 p.

Research output: Contribution to journalArticle

105 Scopus citations
10 Scopus citations

Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+

Cody, V., Galitsky, N., Rak, D., Luft, J. R., Pangborn, W. & Queener, S. F., Apr 6 1999, In : Biochemistry. 38, 14, p. 4303-4312 10 p.

Research output: Contribution to journalArticle

65 Scopus citations

Mast cells mediate the severity of experimental cystitis in mice

Bjorling, D. E., Jerde, T. J., Zine, M. J., Busser, B. W., Saban, M. R. & Saban, R., 1999, In : Journal of Urology. 162, 1, p. 231-236 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

Membrane orientation of carboxyl-terminal half P-glycoprotein: Topogenesis of transmembrane segments

Han, E. S. & Zhang, J. T., Sep 1999, In : European Journal of Cell Biology. 78, 9, p. 624-631 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

One-step synthesis of novel 2,4-diaminopyrimidine antifolates from bridged alicyclic ketones and cyanoguanidine

Rosowsky, A., Papoulis, A. T. & Queener, S. F., Jan 1 1999, In : Journal of Heterocyclic Chemistry. 36, 3, p. 723-728 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
9 Scopus citations
101 Scopus citations

Regulation of cell movement is mediated by stretch-activated calcium channels

Lee, J., Ishihara, A., Oxford, G., Johnson, B. & Jacobson, K., Jul 22 1999, In : Nature. 400, 6742, p. 382-386 5 p.

Research output: Contribution to journalArticle

295 Scopus citations

Structure-based design of selective inhibitors of dihydrofolate reductase: Synthesis and antiparasitic activity of 2,4-diaminopteridine analogues with a bridged diarylamine side chain

Rosowsky, A., Cody, V., Galitsky, N., Fu, H., Papoulis, A. T. & Queener, S. F., Dec 8 1999, In : Journal of Medicinal Chemistry. 42, 23, p. 4853-4860 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Synergistic effect of gemcitabine and irinotecan (CPT-11) on breast and small cell lung cancer cell lines

Bahadori, H. R., Rocha Lima, C. M. S., Green, M. R. & Safa, A. R., Nov 1 1999, In : Anticancer Research. 19, 6 B, p. 5423-5428 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Synthesis and antiparasitic and antitumor activity of 2,4-diamino-6- (arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim

Rosowsky, A., Papoulis, A. T., Forsch, R. A. & Queener, S. F., Mar 25 1999, In : Journal of Medicinal Chemistry. 42, 6, p. 1007-1017 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Synthesis and anti-Pneumocystis carinii activity of conformationally restricted analogues of pentamidine

Tao, B., Huang, T. L., Zhang, Q., Jackson, L., Queener, S. F. & Donkor, I. O., Jun 1999, In : European Journal of Medicinal Chemistry. 34, 6, p. 531-538 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5- substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase

Gangjee, A., Mavandadi, F., Kisliuk, R. L. & Queener, S. F., Jun 17 1999, In : Journal of Medicinal Chemistry. 42, 12, p. 2272-2279 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

The cAMP transduction cascade mediates the PGE2-induced inhibition of potassium currents in rat sensory neurones

Evans, A. R., Vasko, M. R. & Nicol, G. D., Apr 1 1999, In : Journal of Physiology. 516, 1, p. 163-178 16 p.

Research output: Contribution to journalArticle

87 Scopus citations

Topogenesis of cystic fibrosis transmembrane conductance regulator (CFTR): Regulation by the amino terminal transmembrane sequences

Chen, M. & Zhang, J. T., Apr 27 1999, In : Biochemistry. 38, 17, p. 5471-5477 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons

Black, J. A., Cummins, T. R., Plumpton, C., Chen, Y. H., Hormuzdiar, W., Clare, J. J. & Waxman, S. G., Jan 1 1999, In : Journal of Neurophysiology. 82, 5, p. 2776-2785 10 p.

Research output: Contribution to journalArticle

248 Scopus citations
1998
28 Scopus citations
45 Scopus citations

A chromosomal integration system for development of polyvalent vaccine strains

Tu, H. L., Li, S. Q., Dong, Z. Z. & Zhang, Z. S., Dec 1 1998, In : Acta Genetica Sinica. 25, 6, p. 557-558 2 p.

Research output: Contribution to journalArticle

Dihydropyridine receptor isoform expression in adult rat skeletal muscle

Péréon, Y., Dettbarn, C., Lu, Y., Westlund, K. N., Zhang, J. T. & Palade, P., 1998, In : Pflugers Archiv European Journal of Physiology. 436, 3, p. 309-314 6 p.

Research output: Contribution to journalArticle

21 Scopus citations
23 Scopus citations

Dissection of drug-binding-induced conformational changes in P-glycoprotein

Wang, G., Pincheira, R. & Zhang, J. T., Jul 15 1998, In : European Journal of Biochemistry. 255, 2, p. 383-390 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

DNA methylation contributes to expression of the human neurotensin/neuromedin N gene

Dong, Z., Wang, X., Zhao, Q., Townsend, C. M. & Evers, B. M., Mar 1 1998, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 274, 3 37-3, p. G535-G543

Research output: Contribution to journalArticle

24 Scopus citations

Enterocyte-like differentiation of the Caco-2 intestinal cell line is associated with increases in AP-1 protein binding

Ding, Q., Dong, Z. & Evers, B. M., Dec 11 1998, In : Life Sciences. 64, 3, p. 175-182 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Human dopamine D3 and D2L receptors couple to inward rectifier potassium channels in mammalian cell lines

Kuzhikandathil, E. V., Yu, W. & Oxford, G. S., Dec 1998, In : Molecular and Cellular Neurosciences. 12, 6, p. 390-402 13 p.

Research output: Contribution to journalArticle

84 Scopus citations

Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices

Southall, M. D., Michael, R. L. & Vasko, M. R., Oct 1 1998, In : Pain. 78, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

72 Scopus citations

Mechanism involved in generating the carboxyl-terminal half topology of P-glycoprotein

Han, E. S. & Zhang, J. T., Aug 25 1998, In : Biochemistry. 37, 34, p. 11996-12004 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Regulation of extracellular dopamine by the norepinephrine transporter

Yamamoto, B. K. & Novotney, S., Jul 1998, In : Journal of Neurochemistry. 71, 1, p. 274-280 7 p.

Research output: Contribution to journalArticle

205 Scopus citations