Pharmacology & Toxicology

Publications 1971 2020

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1997
48 Citations (Scopus)
Folic Acid Antagonists
Pneumocystis carinii
Purines
Trimethoprim
Toxoplasma
15 Citations (Scopus)

Hepatobiliary excretion of bile acids and rose bengal in streptozotocin- induced and genetic diabetic rats

Stone, J. L., Braunstein, J. B., Beaty, T. M., Sanders, R. A. & Watkins, J. B., 1997, In : Journal of Pharmacology and Experimental Therapeutics. 281, 1, p. 412-419 8 p.

Research output: Contribution to journalArticle

Rose Bengal
Streptozocin
Bile Acids and Salts
Bile
Wistar Rats

Identification of vimentin as a primaquine-binding protein from pneumocystis cakinii

Queener, S. & Bolvard, L. A., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

Pneumocystis
Primaquine
vimentin
Vimentin
binding proteins
30 Citations (Scopus)

IMP dehydrogenase from Pneumocystis carinii as a potential drug target

O'Gara, M. J., Lee, C-H., Weinberg, G. A., Nott, J. M. & Queener, S., Jan 1997, In : Antimicrobial Agents and Chemotherapy. 41, 1, p. 40-48 9 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Pneumocystis carinii
Pharmaceutical Preparations
Mycophenolic Acid
Escherichia coli
30 Citations (Scopus)

Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone

Isenberg, J. S., Kolaja, K. L., Ayoubi, S. A., Watkins, J. B. & Klaunig, J. E., Aug 1997, In : Carcinogenesis. 18, 8, p. 1511-1519 9 p.

Research output: Contribution to journalArticle

Rotenone
Liver
Growth
Diet
DNA
4 Citations (Scopus)

In vitro and in vivo models of Pneumocystis carinii

Bartlett, M. S., Queener, S., Shaw, M. M., Durant, P. J., Lee, C-H. & Smith, J. W., Nov 1997, In : Journal of Eukaryotic Microbiology. 44, 6

Research output: Contribution to journalArticle

Pneumocystis
Animal Disease Models
Pneumocystis carinii
Pneumocystis Pneumonia
Antifungal Agents
31 Citations (Scopus)

Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: Activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents

Robson, C., Meek, M. A., Grunwaldt, J. D., Lambert, P. A., Queener, S., Schmidt, D. & Griffin, R. J., 1997, In : Journal of Medicinal Chemistry. 40, 19, p. 3040-3048 9 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
Antineoplastic Agents
106 Citations (Scopus)

Prostaglandins suppress an outward potassium current in embryonic rat sensory neurons

Nicol, G., Vasko, M. & Evans, A. R., 1997, In : Journal of Neurophysiology. 77, 1, p. 167-176 10 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Prostaglandins
Potassium
Dinoprostone
Neurons
36 Citations (Scopus)

Regulation of opioid receptors in rat sensory neurons in culture

Chen, J. J., Dymshitz, J. & Vasko, M., Apr 1997, In : Molecular Pharmacology. 51, 4, p. 666-673 8 p.

Research output: Contribution to journalArticle

Diprenorphine
Opioid Receptors
Sensory Receptor Cells
Ala(2)-MePhe(4)-Gly(5)-enkephalin
Opioid Analgesics
27 Citations (Scopus)

Structural studies on bioactive compounds. 28. Selective activity of triazenyl-substituted pyrimethamine derivatives against Pneumocystis carinii dihydrofolate reductase

Stevens, M. F. G., Phillip, K. S., Rathbone, D. L., O'Shea, D. M., Queener, S., Schwalbe, C. H. & Lambert, P. A., Jun 6 1997, In : Journal of Medicinal Chemistry. 40, 12, p. 1886-1893 8 p.

Research output: Contribution to journalArticle

Triazenes
Pneumocystis carinii
Pyrimethamine
Tetrahydrofolate Dehydrogenase
Inhibitory Concentration 50
32 Citations (Scopus)
Folic Acid Antagonists
Pyrimidines
Tetrahydrofolate Dehydrogenase
Pyrroles
Pneumocystis carinii
10 Citations (Scopus)

Synthesis of 2,4-diaminopteridines with bulky lipophilic groups at the 6-position as inhibitors of Pneumocystis carinii, Toxoplasma gondii, and mammalian dihydrofolate reductase

Rosowsky, A., Forsch, R. A., Queener, S. & Bertino, J. R., Sep 1997, In : Pteridines. 8, 3, p. 173-187 15 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
2-Naphthylamine
Inhibitory Concentration 50
119 Citations (Scopus)

Tumor necrosis factor enhances the capsaicin sensitivity of rat sensory neurons

Nicol, G., Lopshire, J. C. & Pafford, C. M., 1997, In : Journal of Neuroscience. 17, 3, p. 975-982 8 p.

Research output: Contribution to journalArticle

Capsaicin
Sensory Receptor Cells
Tumor Necrosis Factor-alpha
Neurons
Cobalt
1996
115 Citations (Scopus)

2,4-Diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases

Gangjee, A., Vasudevan, A., Queener, S. & Kisliuk, R. L., Mar 29 1996, In : Journal of Medicinal Chemistry. 39, 7, p. 1438-1446 9 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Methylation
Toxoplasma
Benzaldehydes
42 Citations (Scopus)

2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase

Gangjee, A., Mavandadi, F., Kisliuk, R. L., McGuire, J. J. & Queener, S., 1996, In : Journal of Medicinal Chemistry. 39, 23, p. 4563-4568 6 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Thymidylate Synthase
Liver
Rats
Glutamic Acid
14 Citations (Scopus)

6,7-disubstituted 2,4-diaminopteridines: Novel inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Jackson, H. C., Biggadike, K., McKilligin, E., Kinsman, O. S., Queener, S., Lane, A. & Smith, J. E., Jun 1996, In : Antimicrobial Agents and Chemotherapy. 40, 6, p. 1371-1375 5 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Pyrimethamine
Tetrahydrofolate Dehydrogenase
Toxoplasma
Trimethoprim
83 Citations (Scopus)

Activation of protein kinase C augments peptide release from rat sensory neurons

Barber, L. A. & Vasko, M., Jul 1996, In : Journal of Neurochemistry. 67, 1, p. 72-80 9 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Protein Kinase C
Neurons
Rats
Phorbol 12,13-Dibutyrate
21 Citations (Scopus)

Brominated trimetrexate analogues as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Rosowsky, A., Mota, C. E. & Queener, S., Nov 1996, In : Journal of Heterocyclic Chemistry. 33, 6, p. 1959-1966 8 p.

Research output: Contribution to journalArticle

Trimetrexate
Tetrahydrofolate Dehydrogenase
Quinazolines
Substitution reactions
Railroad cars

Demonstration of esterase activity in Pneumocystis carinii by cleavage of 4-methylumbelliferyl substrates

Durant, P. J., Bartlett, M. S., Shaw, M. M., Queener, S. & Smith, J. W., Sep 1996, In : Journal of Eukaryotic Microbiology. 43, 5

Research output: Contribution to journalArticle

Hymecromone
Pneumocystis
Pneumocystis carinii
Esterases
Cell Line
86 Citations (Scopus)

Differential regulation of evoked peptide release by voltage-sensitive calcium channels in rat sensory neurons

Evans, A. R., Nicol, G. & Vasko, M., Mar 18 1996, In : Brain Research. 712, 2, p. 265-273 9 p.

Research output: Contribution to journalArticle

Conotoxins
Sensory Receptor Cells
Calcium Channels
Agatoxins
Dinoprostone
23 Citations (Scopus)

Dopamine, serotonin and tachykinin in self-injurious behavior

Sivam, S., May 24 1996, In : Life Sciences. 58, 26, p. 2367-2375 9 p.

Research output: Contribution to journalArticle

Tachykinins
Self-Injurious Behavior
Dopamine
Serotonin
Biosynthesis
4 Citations (Scopus)

Dopaminergic regulation of postnatal development of dynorphin neurons in rat striatum

Sivam, S., 1996, In : Neuropeptides. 30, 1, p. 103-107 5 p.

Research output: Contribution to journalArticle

Dynorphins
Neurons
Rats
Dopamine
Oxidopamine
7 Citations (Scopus)
Dopamine Uptake Inhibitors
Dynorphins
Tachykinins
Neurokinin A
Gene Expression
2 Citations (Scopus)

Evaluation of sulfa drugs against recombinant Pneumocystis carinii dihydropteroate synthetase and in vivo

Hong, Y. L., Hossler, P., Bartlett, M., Queener, S., Smith, J. & Meshnick, S., Sep 1996, In : Journal of Eukaryotic Microbiology. 43, 5

Research output: Contribution to journalArticle

Sulfanilamides
Sulfamethoxypyridazine
Dihydropteroate Synthase
Pneumocystis
Pneumocystis carinii
1 Citation (Scopus)

Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury

Omar, H. M., Sanders, R. A. & Watkins, J. B., 1996, In : Inflammation Research. 45, 10, p. 519-523 5 p.

Research output: Contribution to journalArticle

Leukotriene C4
Leukotrienes
Theoretical Models
Liver
Wounds and Injuries
30 Citations (Scopus)
Dihydropteroate Synthase
Sulfamethoxazole
Pneumocystis carinii
Mycobacterium avium
Sulfonamides
55 Citations (Scopus)

Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations

Piper, J. R., Johnson, C. A., Krauth, C. A., Carter, R. L., Hosmer, C. A., Queener, S., Borotz, S. E. & Pfefferkorn, E. R., Mar 15 1996, In : Journal of Medicinal Chemistry. 39, 6, p. 1271-1280 10 p.

Research output: Contribution to journalArticle

Trimetrexate
Folic Acid Antagonists
Pneumocystis carinii
Opportunistic Infections
Toxoplasma
12 Citations (Scopus)

Minimal effect of acute experimental hepatitis induced by lipopolysaccharide/D-galactosamine on biotransformation in rats

Omar, H. E. D. M., Sanders, R. A. & Watkins, J. B., Dec 24 1996, In : Biochemical Pharmacology. 52, 12, p. 1921-1924 4 p.

Research output: Contribution to journalArticle

Galactosamine
Biotransformation
Hepatitis
Lipopolysaccharides
Rats
30 Citations (Scopus)

Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii

Gangjee, A., Zhu, Y., Queener, S., Francom, P. & Broom, A. D., Apr 26 1996, In : Journal of Medicinal Chemistry. 39, 9, p. 1836-1845 10 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Toxoplasma
Liver
Rats
33 Citations (Scopus)

Peptidase inhibitors improve recovery of substance P and calcitonin gene-related peptide release from rat spinal cord slices

Chen, J. J., Barber, L. A., Dymshitz, J. & Vasko, M., 1996, In : Peptides. 17, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
phenylalanylalanine
Substance P
Protease Inhibitors
Rats
50 Citations (Scopus)

Semisynthetic echinocandins affect cell wall deposition of Pneumocystis carinii in vitro and in vivo

Bartlett, M. S., Current, W. L., Goheen, M. P., Boylan, C. J., Lee, C-H., Shaw, M. M., Queener, S. & Smith, J. W., Aug 1996, In : Antimicrobial Agents and Chemotherapy. 40, 8, p. 1811-1816 6 p.

Research output: Contribution to journalArticle

Echinocandins
Pneumocystis carinii
Cell Wall
anidulafungin
Pneumocystis Pneumonia
5 Citations (Scopus)

Sulfa resistance in mouse-derived Pneumocystis carinii

Lane, B., Hossler, P., Bartlett, M., Queener, S., O'Reelly, T., Smith, J. & Meshnick, S., Sep 1996, In : Journal of Eukaryotic Microbiology. 43, 5

Research output: Contribution to journalArticle

Molecular Sequence Data
Dihydropteroate Synthase
Pneumocystis
Sulfamethoxazole
Pneumocystis carinii
17 Citations (Scopus)

Synthesis and anti-Pneumocystis carinii activity of piperidine-linked aromatic diimidazolines

Huang, T. L., Zhang, Q., White, A. T., Queener, S., Bartlett, M. S., Smith, J. W. & Donkor, I. O., Sep 3 1996, In : Bioorganic and Medicinal Chemistry Letters. 6, 17, p. 2087-2090 4 p.

Research output: Contribution to journalArticle

Pentamidine
Pneumocystis carinii
Pharmaceutical Preparations
Growth
piperidine
10 Citations (Scopus)

Synthesis of a series of diaminobenzo[f]- and diaminobenzo[h]pyrimido[4,5-b]quinolines as 5-daza tetracyclic nonclassical antifolates

Donkor, I. O., Devraj, R., Queener, S., Barrows, L. R. & Gangjee, A., 1996, In : Journal of Heterocyclic Chemistry. 33, 6, p. 1653-1661 9 p.

Research output: Contribution to journalArticle

Quinolines
Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Liver
Rats
17 Citations (Scopus)

Types of Pneumocystis carinii detected in air samples

Bartlett, M. S., Lu, J. J., Lee, C-H., Durant, P. J., Queener, S. & Smith, J. W., Sep 1996, In : Journal of Eukaryotic Microbiology. 43, 5

Research output: Contribution to journalArticle

Mycological Typing Techniques
Air Microbiology
Pneumocystis
Pneumocystis carinii
Patients' Rooms
1995
18 Citations (Scopus)
Quinazolines
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
Mutation
35 Citations (Scopus)

2,4-Diaminopyrido[3,2-d]pyrimidine inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii

Rosowsky, A., Forsch, R. A. & Queener, S., 1995, In : Journal of Medicinal Chemistry. 38, 14, p. 2615-2620 6 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Toxoplasma
Thymidine Monophosphate
Liver
65 Citations (Scopus)
Folic Acid Antagonists
Pneumocystis carinii
Pyrimidines
Tetrahydrofolate Dehydrogenase
Toxoplasma
1 Citation (Scopus)

Biotransformation in Egyptian spiny mouse Acomys cahirinus

Watkins, J. B., LaFollette, J. W. & Sanders, R. A., 1995, In : Comparative Biochemistry and Physiology. Part C: Comparative. 110, 1, p. 101-107 7 p.

Research output: Contribution to journalArticle

Murinae
Biotransformation
Intestines
Kidney
Liver
97 Citations (Scopus)

Cyclic AMP mediates the prostaglandin E2-induced potentiation of bradykinin excitation in rat sensory neurons

Cui, M. & Nicol, G., 1995, In : Neuroscience. 66, 2, p. 459-466 8 p.

Research output: Contribution to journalArticle

Bradykinin
Sensory Receptor Cells
Dinoprostone
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases
47 Citations (Scopus)

Diabetes mellitus-induced alterations of hepatobiliary function

Watkins, J. B. & Sanders, R. A., 1995, In : Pharmacological Reviews. 47, 1, p. 1-23 23 p.

Research output: Contribution to journalArticle

Alloxan
Experimental Diabetes Mellitus
Streptozocin
Biotransformation
Bile Acids and Salts
38 Citations (Scopus)

Diagnosis of Pneumocystis carinii pneumonia in AIDS patients by using polymerase chain reactions on serum specimens

Atzori, C., Lu, J. J., Jiang, B., Bartlett, M. S., Orlando, G., Queener, S., Smith, J. W., Cargnel, A. & Lee, C-H., Dec 1995, In : Journal of Infectious Diseases. 172, 6, p. 1623-1626 4 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Acquired Immunodeficiency Syndrome
Polymerase Chain Reaction
Serum
Pneumocystis carinii
18 Citations (Scopus)

Dopaminergic modulation of serotonin metabolism in rat striatum: A study with dopamine uptake inhibitor GBR-12909

Sivam, S., May 19 1995, In : Life Sciences. 56, 26, p. 467-472 6 p.

Research output: Contribution to journalArticle

Dopamine Uptake Inhibitors
Metabolism
3,4-Dihydroxyphenylacetic Acid
Rats
Dopamine
28 Citations (Scopus)

Evaluation of potent inhibitors of dihydrofolate reductase in a culture model for growth of Pneumocystis carinii

Bartlett, M. S., Shaw, M., Navaran, P., Smith, J. W. & Queener, S., 1995, In : Antimicrobial Agents and Chemotherapy. 39, 11, p. 2436-2441 6 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Trimetrexate
Tetrahydrofolate Dehydrogenase
Growth
24 Citations (Scopus)

GBR-12909-induced self-injurious behavior: role of dopamine

Sivam, S., Sep 4 1995, In : Brain Research. 690, 2, p. 259-263 5 p.

Research output: Contribution to journalArticle

Self-Injurious Behavior
Dopamine
Oxidopamine
Corpus Striatum
Spiperone
33 Citations (Scopus)

Integration of pharmacology into a problem-based learning curriculum for medical students

Sivam, S., Iatridis, P. G. & Vaughn, S., 1995, In : Medical Education. 29, 4, p. 289-296 8 p.

Research output: Contribution to journalArticle

pharmacology
Problem-Based Learning
Medical Students
medical student
Pharmacology
7 Citations (Scopus)

Minimal effects of two aldose reductase inhibitors, AL-1576 and AL-4114, after subacute topical-ocular dosing on xenobiotic biotransformation in rabbits

Sastry, S. G., Sanders, R. A., Veltman, J. C. & Watkins, J. B., 1995, In : Drug Metabolism and Disposition. 23, 10, p. 1094-1098 5 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Xenobiotics
Biotransformation
Rabbits
Tissue
73 Citations (Scopus)
Pneumocystis
Pneumocystis Pneumonia
Drug Design
Opportunistic Infections
Structure-Activity Relationship
22 Citations (Scopus)

Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: Synthesis and biological activities

Gangjee, A., Zaveri, N., Kothare, M. & Queener, S., 1995, In : Journal of Medicinal Chemistry. 38, 18, p. 3660-3668 9 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Toxoplasma
Bioactivity
Tumors
55 Citations (Scopus)

Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases

Gangjee, A., Mavandadi, F., Queener, S. & McGuire, J. J., 1995, In : Journal of Medicinal Chemistry. 38, 12, p. 2158-2165 8 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Methotrexate
Liver
Rats