Pharmacology & Toxicology

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2002

cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation

Bhave, G., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S. & Gereau IV, R. W., Aug 15 2002, In : Neuron. 35, 4, p. 721-731 11 p.

Research output: Contribution to journalArticle

417 Scopus citations
130 Scopus citations

Characterization and developmental changes of Na+ currents of petrosal neurons with projections to the carotid body

Cummins, T. R., Dib-Hajj, S. D., Waxman, S. G. & Donnelly, D. F., Dec 1 2002, In : Journal of Neurophysiology. 88, 6, p. 2993-3002 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Characterization of anthracenediones and their photoaffinity analogs

Chou, K. M., Krapcho, A. P., Horn, D. & Hacker, M., Mar 15 2002, In : Biochemical Pharmacology. 63, 6, p. 1143-1147 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
65 Scopus citations

Critical molecular determinants of voltage-gated sodium channel sensitivity to μ-conotoxins GIIIA/B

Cummins, T. R., Aglieco, F. & Dib-Hajj, S. D., May 7 2002, In : Molecular pharmacology. 61, 5, p. 1192-1201 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Cyclooxygenase-2 expression is up-regulated in obstructed human ureter

Nakada, S. Y., Jerde, T. J., Jacobson, L. M., Saban, R., Bjorling, D. E. & Hullett, D. A., Sep 2002, In : Journal of Urology. 168, 3, p. 1226-1229 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

Cytoplasmic retraction of the amino terminus of human multidrug resistance protein 1

Chen, Q., Yang, Y., Liu, Y., Han, B. & Zhang, J. T., Jul 23 2002, In : Biochemistry. 41, 29, p. 9052-9062 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Dimerization of human XPA and formation of XPA2-RPA protein complex

Yang, Z. G., Liu, Y., Mao, L. Y., Zhang, J. T. & Zou, Y., Oct 29 2002, In : Biochemistry. 41, 43, p. 13012-13020 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Effects of combined Quercetin and coenzyme Q10 treatment on oxidative stress in normal and diabetic rats

Coldiron, A. D., Sanders, R. A. & Watkins, J. B., Oct 23 2002, In : Journal of Biochemical and Molecular Toxicology. 16, 4, p. 197-202 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Effects of β-carotene on oxidative stress in normal and diabetic rats

Maritim, A., Dene, B. A., Sanders, R. A. & Watkins, J. B., Oct 23 2002, In : Journal of Biochemical and Molecular Toxicology. 16, 4, p. 203-208 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs

Kilts, J. D., Connery, H. S., Arrington, E. G., Lewis, M. M., Lawler, C. P., Oxford, G. S., O'Malley, K. L., Todd, R. D., Blake, B. L., Nichols, D. E. & Mailman, R. B., Jun 17 2002, In : Journal of Pharmacology and Experimental Therapeutics. 301, 3, p. 1179-1189 11 p.

Research output: Contribution to journalArticle

66 Scopus citations

GDNF and NGF reverse changes in repriming of TTX-sensitive Na + currents following axotomy of dorsal root ganglion neurons

Leffler, A., Cummins, T. R., Dib-Hajj, S. D., Hormuzdiar, W. N., Black, J. A. & Waxman, S. G., Aug 23 2002, In : Journal of Neurophysiology. 88, 2, p. 650-658 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

HSV-1 helper virus 5d11.2 suppresses sodium currents in amplicon-transduced neurons

White, B. H., Cummins, T. R., Wolf, D. H., Waxman, S. G., Russell, D. S. & Kaczmarek, L. K., Jan 1 2002, In : Journal of Neurophysiology. 87, 4, p. 2149-2157 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Impairment of slow inactivation as a common mechanism for periodic paralysis in dIIS4-S5

Bendahhou, S., Cummins, T. R., Kula, R. W., Fu, Y. H. & Ptácek, L. J., Apr 23 2002, In : Neurology. 58, 8, p. 1266-1272 7 p.

Research output: Contribution to journalArticle

59 Scopus citations

Inclusion of a competency-based curriculum in medical pharmacology

Near, J. A., Bosin, T. R. & Watkins, J. B., Jun 26 2002, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 366, 1, p. 26-29 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
44 Scopus citations

Irinotecan and gemcitabine in patients with solid tumors: phase I trial.

Rocha Lima, C. M., Leong, S. S., Sherman, C. A., Perkel, J. A., Putman, T., Safa, A. R. & Green, M. R., May 2002, In : Oncology (Williston Park, N.Y.). 16, 5 Suppl 5, p. 19-24 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mechanism of β2- microglobulin-induced apoptosis in the K562 leukemia cell line, defective in major histocompatibility class 1

Wu, C. H., Gordon, J. D., Zhong, X. & Safa, A. R., Sep 1 2002, In : Anticancer Research. 22, 5, p. 2613-2621 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mechanisms of the release of anterogradely transported neurotrophin-3 from axon terminals

Wang, X., Butowt, R., Vasko, M. R. & Von Bartheld, C. S., Feb 1 2002, In : Journal of Neuroscience. 22, 3, p. 931-945 15 p.

Research output: Contribution to journalArticle

53 Scopus citations

Molecular determinant of Nav1.8 sodium channel resistance to the venom from the scorpion Leiurus quinquestriatus hebraeus

Saab, C. Y., Cummins, T. R., Dib-Hajj, S. D. & Waxman, S. G., Oct 11 2002, In : Neuroscience Letters. 331, 2, p. 79-82 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

Nass, R., Hall, D. H., Miller, D. M. & Blakely, R. D., Mar 5 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 5, p. 3264-3269 6 p.

Research output: Contribution to journalArticle

244 Scopus citations

Nitric oxide blocks fast, slow, and persistent Na+ channels in C-type DRG neurons by S-nitrosylation

Renganathan, M., Cummins, T. R. & Waxman, S. G., Jan 1 2002, In : Journal of Neurophysiology. 87, 2, p. 761-775 15 p.

Research output: Contribution to journalArticle

86 Scopus citations

Participation of the conventional calpains in apoptosis

Lu, T., Xu, Y., Mericle, M. T. & Mellgren, R. L., Jun 12 2002, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1590, 1-3, p. 16-26 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant

Wu, C. H., Gordon, J., Rastegar, M., Ogretmen, B. & Safa, A. R., Jan 1 2002, In : Oncogene. 21, 33, p. 5160-5174 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regulation of gene expression by internal ribosome entry sites or cryptic promoters: The eIF4G story

Han, B. & Zhang, J. T., Nov 1 2002, In : Molecular and cellular biology. 22, 21, p. 7372-7384 13 p.

Research output: Contribution to journalArticle

95 Scopus citations

Sodium channel expression in hypothalamic osmosensitive neurons in experimental diabetes

Klein, J. P., Craner, M. J., Cummins, T. R., Black, J. A. & Waxman, S. G., Aug 7 2002, In : NeuroReport. 13, 11, p. 1481-1484 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1

Yang, Y., Chen, Q. & Zhang, J. T., Nov 15 2002, In : Journal of Biological Chemistry. 277, 46, p. 44268-44277 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Structural studies on bioactive compounds. Part 36: Design, synthesis and biological evaluation of pyrimethamine-based antifolates against Pneumocystis carinii

Chan, D. C. M., Laughton, C. A., Queener, S. F. & Stevens, M. F. G., Jul 23 2002, In : Bioorganic and Medicinal Chemistry. 10, 9, p. 3001-3010 10 p.

Research output: Contribution to journalArticle

32 Scopus citations
22 Scopus citations

Twenty-four hour exposure to prostaglandin downregulates prostanoid receptor binding but does not alter PGE2-mediated sensitization of rat sensory neurons

Southall, M. D., Bolyard, L. A. & Vasko, M. R., Apr 27 2002, In : Pain. 96, 3, p. 285-296 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2001

A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities

Kearney, J. A., Plummer, N. W., Smith, M. R., Kapur, J., Cummins, T. R., Waxman, S. G., Goldin, A. L. & Meisler, M. H., Jan 15 2001, In : Neuroscience. 102, 2, p. 307-317 11 p.

Research output: Contribution to journalArticle

171 Scopus citations
86 Scopus citations

C. elegans: A novel pharmacogenetic model to study Parkinson's disease

Nass, R., Miller, D. M. & Blakely, R. D., May 7 2001, In : Parkinsonism and Related Disorders. 7, 3, p. 185-191 7 p.

Research output: Contribution to journalArticle

59 Scopus citations

Changes in the kinetic parameters of hepatic γ-glutamyltransferase from streptozotocin-induced diabetic rats

Cornwell, P. D. & Watkins, J. B., Feb 9 2001, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1545, 1-2, p. 184-191 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Characterization of oxidative stress in various tissues of diabetic and galactose-fed rats

Strother, R. M., Thomas, T. G., Otsyula, M., Sanders, R. A. & Watkins, J. B., Jan 1 2001, In : International Journal of Experimental Diabetes Research. 2, 3, p. 211-216 6 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Conformationally restricted tricyclic analogues of lipophilic pyrido[2, 3-d]pyrimidine antifolates [1a, b]

Gangjee, A., Mavandadi, F. & Queener, S. F., Jan 1 2001, In : Journal of Heterocyclic Chemistry. 38, 1, p. 213-220 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Contribution of Nav 1.8 sodium channels to action potential electrogenesis in DRG neurons

Renganathan, M., Cummins, T. R. & Waxman, S. G., Aug 22 2001, In : Journal of Neurophysiology. 86, 2, p. 629-640 12 p.

Research output: Contribution to journalArticle

389 Scopus citations

Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from pneumocystis carinii

Graffner-Nordberg, M., Kolmodin, K., Åqvist, J., Queener, S. F. & Hallberg, A., Jul 19 2001, In : Journal of Medicinal Chemistry. 44, 15, p. 2391-2402 12 p.

Research output: Contribution to journalArticle

84 Scopus citations

Differential splicing of Pneumocystis carinii f. sp. carinii inosine 5′-monophosphate dehydrogenase pre-mRNA

Ye, D., Lee, C. H. & Queener, S. F., Jan 24 2001, In : Gene. 263, 1-2, p. 151-158 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Effects of coenzyme Q10 treatment on antioxidant pathways in normal and streptozotocin-induced diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., Feb 19 2001, In : Journal of Biochemical and Molecular Toxicology. 15, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

85 Scopus citations

Effects of isoeugenol on oxidative stress pathways in normal and streptozotocin-induced diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., Jun 19 2001, In : Journal of Biochemical and Molecular Toxicology. 15, 3, p. 159-164 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Effects of Quercetin on antioxidant defense in streptozotocin-induced diabetic rats

Sanders, R. A., Rauscher, F. M. & Watkins, J. B., Jun 19 2001, In : Journal of Biochemical and Molecular Toxicology. 15, 3, p. 143-149 7 p.

Research output: Contribution to journalArticle

122 Scopus citations

Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate

Nixdorf, W. L., Burrows, K. B., Gudelsky, G. A. & Yamamoto, B. K., Apr 25 2001, In : Journal of Neurochemistry. 77, 2, p. 647-654 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation

Kuzhikandathil, E. V., Wang, H., Szabo, T., Morozova, N., Blumberg, P. M. & Oxford, G. S., Nov 15 2001, In : Journal of Neuroscience. 21, 22, p. 8697-8706 10 p.

Research output: Contribution to journalArticle

103 Scopus citations

Identification of a 170-kDa protein over-expressed in lung cancers

Pincheira, R., Chen, Q. & Zhang, J. T., Jun 1 2001, In : British Journal of Cancer. 84, 11, p. 1520-1527 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Impact of the basic amine on the biological activity and intracellular distribution of an aza-anthrapyrazole: BBR 3422

Chou, K. M., Paul Krapcho, A. & Hacker, M. P., Dec 15 2001, In : Biochemical Pharmacology. 62, 10, p. 1337-1343 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Improved method for the measurement of large neutral amino acids in biological matrices

Bongiovanni, R., Yamamoto, B. K. & Jaskiw, G. E., Apr 25 2001, In : Journal of Chromatography B: Biomedical Sciences and Applications. 754, 2, p. 369-376 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

In vitro contractile effects of neurokinin receptor blockade in the human ureter

Nakada, S. Y., Jerde, T. J., Bjorling, D. E. & Saban, R., Jan 1 2001, In : Journal of Urology. 166, 4, p. 1534-1538 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Isolation of rat dihydrofolate reductase gene and characterization of recombinant enzyme

Wang, Y., Bruenn, J. A., Queener, S. F. & Cody, V., Sep 12 2001, In : Antimicrobial Agents and Chemotherapy. 45, 9, p. 2517-2523 7 p.

Research output: Contribution to journalArticle

17 Scopus citations