Pharmacology & Toxicology

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1997

Conformational changes of P-glycoprotein by nucleotide binding

Wang, G., Pincheira, R., Zhang, M. & Zhang, J. T., Dec 15 1997, In : Biochemical Journal. 328, 3, p. 897-904 8 p.

Research output: Contribution to journalArticle

57 Scopus citations
49 Scopus citations

Construction of bivalent vaccine candidate expressing CS3 fimbriae and cholera toxin B subunit

Dong, Z., Li, S. & Zhang, Z., Sep 1 1997, In : Chinese Journal of Microbiology and Immunology. 17, 5, p. 348-351 4 p.

Research output: Contribution to journalArticle

Hepatobiliary excretion of bile acids and rose bengal in streptozotocin- induced and genetic diabetic rats

Stone, J. L., Braunstein, J. B., Beaty, T. M., Sanders, R. A. & Watkins, J. B., May 24 1997, In : Journal of Pharmacology and Experimental Therapeutics. 281, 1, p. 412-419 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Identification of vimentin as a primaquine-binding protein from pneumocystis cakinii

Queener, S. F. & Bolvard, L. A., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1269

Research output: Contribution to journalArticle

IMP dehydrogenase from Pneumocystis carinii as a potential drug target

O'Gara, M. J., Lee, C. H., Weinberg, G. A., Nott, J. M. & Queener, S. F., Jan 1997, In : Antimicrobial Agents and Chemotherapy. 41, 1, p. 40-48 9 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone

Isenberg, J. S., Kolaja, K. L., Ayoubi, S. A., Watkins, J. B. & Klaunig, J. E., Aug 1 1997, In : Carcinogenesis. 18, 8, p. 1511-1519 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

In vitro and in vivo models of Pneumocystis carinii

Bartlett, M. S., Queener, S. F., Shaw, M. M., Durant, P. J., Lee, C. H. & Smith, J. W., Nov 1 1997, In : Journal of Eukaryotic Microbiology. 44, 6, p. 51S

Research output: Contribution to journalArticle

4 Scopus citations

Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: Activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents

Robson, C., Meek, M. A., Grunwaldt, J. D., Lambert, P. A., Queener, S. F., Schmidt, D. & Griffin, R. J., Sep 26 1997, In : Journal of Medicinal Chemistry. 40, 19, p. 3040-3048 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Prostaglandins suppress an outward potassium current in embryonic rat sensory neurons

Nicol, G. D., Vasko, M. R. & Evans, A. R., Jan 1 1997, In : Journal of Neurophysiology. 77, 1, p. 167-176 10 p.

Research output: Contribution to journalArticle

107 Scopus citations

Regulation of opioid receptors in rat sensory neurons in culture

Chen, J. J., Dymshitz, J. & Vasko, M. R., Apr 1997, In : Molecular Pharmacology. 51, 4, p. 666-673 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Role of ribosomes in reinitiation of membrane insertion of internal transmembrane segments in a polytopic membrane protein

Wang, C., Chen, M., Han, E. & Zhang, J. T., Sep 23 1997, In : Biochemistry. 36, 38, p. 11437-11443 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structural studies on bioactive compounds. 28. Selective activity of triazenyl-substituted pyrimethamine derivatives against Pneumocystis carinii dihydrofolate reductase

Stevens, M. F. G., Phillip, K. S., Rathbone, D. L., O'Shea, D. M., Queener, S. F., Schwalbe, C. H. & Lambert, P. A., Jun 6 1997, In : Journal of Medicinal Chemistry. 40, 12, p. 1886-1893 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
33 Scopus citations

Synthesis of 2,4-diaminopteridines with bulky lipophilic groups at the 6-position as inhibitors of Pneumocystis carinii, Toxoplasma gondii, and mammalian dihydrofolate reductase

Rosowsky, A., Forsch, R. A., Queener, S. F. & Bertino, J. R., Sep 1997, In : Pteridines. 8, 3, p. 173-187 15 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons

Koplas, P. A., Rosenberg, R. L. & Oxford, G. S., 1997, In : Journal of Neuroscience. 17, 10, p. 3525-3537 13 p.

Research output: Contribution to journalArticle

Open Access
245 Scopus citations

Tumor necrosis factor enhances the capsaicin sensitivity of rat sensory neurons

Nicol, G. D., Lopshire, J. C. & Pafford, C. M., Feb 1 1997, In : Journal of Neuroscience. 17, 3, p. 975-982 8 p.

Research output: Contribution to journalArticle

121 Scopus citations
1996

2,4-Diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases

Gangjee, A., Vasudevan, A., Queener, S. F. & Kisliuk, R. L., Mar 29 1996, In : Journal of Medicinal Chemistry. 39, 7, p. 1438-1446 9 p.

Research output: Contribution to journalArticle

117 Scopus citations

2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase

Gangjee, A., Mavandadi, F., Kisliuk, R. L., McGuire, J. J. & Queener, S. F., Nov 26 1996, In : Journal of Medicinal Chemistry. 39, 23, p. 4563-4568 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

6,7-disubstituted 2,4-diaminopteridines: Novel inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Jackson, H. C., Biggadike, K., McKilligin, E., Kinsman, O. S., Queener, S. F., Lane, A. & Smith, J. E., Jun 1 1996, In : Antimicrobial Agents and Chemotherapy. 40, 6, p. 1371-1375 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Activation of protein kinase C augments peptide release from rat sensory neurons

Barber, L. A. & Vasko, M. R., Jul 1996, In : Journal of Neurochemistry. 67, 1, p. 72-80 9 p.

Research output: Contribution to journalArticle

83 Scopus citations

Brominated trimetrexate analogues as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Rosowsky, A., Mota, C. E. & Queener, S. F., Jan 1 1996, In : Journal of Heterocyclic Chemistry. 33, 6, p. 1959-1966 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Co-translational effects of temperature on membrane insertion and orientation of P-glycoprotein sequences

Zhang, J. T. & Chong, C. H., Jan 1 1996, In : Molecular and Cellular Biochemistry. 159, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Demonstration of esterase activity in Pneumocystis carinii by cleavage of 4-methylumbelliferyl substrates

Durant, P. J., Bartlett, M. S., Shaw, M. M., Queener, S. F. & Smith, J. W., Sep 1 1996, In : Journal of Eukaryotic Microbiology. 43, 5, p. 45S

Research output: Contribution to journalArticle

Differential regulation of evoked peptide release by voltage-sensitive calcium channels in rat sensory neurons

Evans, A. R., Nicol, G. D. & Vasko, M. R., Mar 18 1996, In : Brain research. 712, 2, p. 265-273 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

Dopaminergic regulation of postnatal development of dynorphin neurons in rat striatum

Sivam, S. P., Jan 1 1996, In : Neuropeptides. 30, 1, p. 103-107 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
7 Scopus citations

Evaluation of sulfa drugs against recombinant Pneumocystis carinii dihydropteroate synthetase and in vivo

Hong, Y. L., Hossler, P., Bartlett, M., Queener, S., Smith, J. & Meshnick, S., 1996, In : Journal of Eukaryotic Microbiology. 43, 5, p. 40S

Research output: Contribution to journalArticle

2 Scopus citations

Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury

Omar, H. M., Sanders, R. A. & Watkins, J. B., Nov 7 1996, In : Inflammation Research. 45, 10, p. 519-523 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
30 Scopus citations

Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes

Chen, M. & Zhang, J. T., Jan 1 1996, In : Molecular Membrane Biology. 13, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Membrane integration of in vitro-translated gap junctional proteins: Co- and post-translational mechanisms

Zhang, J. T., Chen, M., Foote, C. I. & Nicholson, B. J., Mar 1996, In : Molecular Biology of the Cell. 7, 3, p. 471-482 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

Minimal effect of acute experimental hepatitis induced by lipopolysaccharide/D-galactosamine on biotransformation in rats

Omar, H. E. D. M., Sanders, R. A. & Watkins, J. B., Dec 24 1996, In : Biochemical Pharmacology. 52, 12, p. 1921-1924 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii

Gangjee, A., Zhu, Y., Queener, S. F., Francom, P. & Broom, A. D., Apr 26 1996, In : Journal of Medicinal Chemistry. 39, 9, p. 1836-1845 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Peptidase inhibitors improve recovery of substance P and calcitonin gene-related peptide release from rat spinal cord slices

Chen, J. J., Barber, L. A., Dymshitz, J. & Vasko, M. R., Jan 1 1996, In : Peptides. 17, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Semisynthetic echinocandins affect cell wall deposition of Pneumocystis carinii in vitro and in vivo

Bartlett, M. S., Current, W. L., Goheen, M. P., Boylan, C. J., Lee, C. H., Shaw, M. M., Queener, S. F. & Smith, J. W., Aug 1996, In : Antimicrobial Agents and Chemotherapy. 40, 8, p. 1811-1816 6 p.

Research output: Contribution to journalArticle

Open Access
54 Scopus citations
30 Scopus citations

Sulfa resistance in mouse-derived Pneumocystis carinii

Lane, B., Hossler, P., Bartlett, M., Queener, S., O'Reelly, T., Smith, J. & Meshnick, S., 1996, In : Journal of Eukaryotic Microbiology. 43, 5, p. 39S

Research output: Contribution to journalArticle

5 Scopus citations

Synthesis and anti-Pneumocystis carinii activity of piperidine-linked aromatic diimidazolines

Huang, T. L., Zhang, Q., White, A. T., Queener, S. F., Bartlett, M. S., Smith, J. W. & Donkor, I. O., Sep 3 1996, In : Bioorganic and Medicinal Chemistry Letters. 6, 17, p. 2087-2090 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Synthesis of a Series of Diaminobenzo[f]- And Diaminobenzo[h]pyrimido[4,5-b]quinolines as 5-Deaza Tetracyclic Nonclassical Antifolates

Donkor, I. O., Devraj, R., Queener, S. F., Barrows, L. R. & Gangjee, A., Jan 1 1996, In : Journal of Heterocyclic Chemistry. 33, 6, p. 1653-1661 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Topological folding and proteolysis profile of P-glycoprotein in membranes of multidrug-resistant cells: Implications for the drug-transport mechanism

Zhang, M., Wang, G., Shapiro, A. & Zhang, J. T., Sep 25 1996, In : Biochemistry. 35, 30, p. 9728-9736 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Types of Pneumocystis carinii detected in air samples

Bartlett, M. S., Lu, J. J., Lee, C. H., Durant, P. J., Queener, S. F. & Smith, J. W., 1996, In : Journal of Eukaryotic Microbiology. 43, 5, p. 44S

Research output: Contribution to journalArticle

17 Scopus citations
1995
18 Scopus citations

2,4- Diaminopyrido[3,2-d]pyrimidine Inhibitors of Dihydrofolate Reductase from Pneumocystis carinii and Toxoplasma gondii

Rosowsky, A., Forsch, R. A. & Queener, S. F., Jul 1 1995, In : Journal of Medicinal Chemistry. 38, 14, p. 2615-2620 6 p.

Research output: Contribution to journalArticle

35 Scopus citations
66 Scopus citations

Biotransformation in Egyptian spiny mouse Acomys cahirinus

Watkins, J. B., LaFollette, J. W. & Sanders, R. A., Jan 1995, In : Comparative Biochemistry and Physiology. Part C: Comparative. 110, 1, p. 101-107 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cyclic AMP mediates the prostaglandin E2-induced potentiation of bradykinin excitation in rat sensory neurons

Cui, M. & Nicol, G. D., May 1995, In : Neuroscience. 66, 2, p. 459-466 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Diagnosis of pneumocystis carinii pneumonia in aids patients by using polymerase chain reactions on serum specimens

Atzori, C., Lu, J. J., Jiang, B., Bartlett, M. S., Orlando, G., Queener, S. F., Smith, J. W., Cargnel, A. & Lee, C. H., Dec 1995, In : Journal of Infectious Diseases. 172, 6, p. 1623-1626 4 p.

Research output: Contribution to journalArticle

38 Scopus citations

Dopaminergic modulation of serotonin metabolism in rat striatum: A study with dopamine uptake inhibitor GBR-12909

Sivam, S. P., May 19 1995, In : Life Sciences. 56, 26, p. 467-472 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Evaluation of potent inhibitors of dihydrofolate reductase in a culture model for growth of Pneumocystis carinii

Bartlett, M. S., Shaw, M., Navaran, P., Smith, J. W. & Queener, S. F., Jan 1 1995, In : Antimicrobial Agents and Chemotherapy. 39, 11, p. 2436-2441 6 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations