Pharmacology & Toxicology

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2001

N,N′-Bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents

Huang, T. L., Tao, B., Quarshie, Y., Queener, S. F. & Donkor, I. O., Oct 22 2001, In : Bioorganic and Medicinal Chemistry Letters. 11, 20, p. 2679-2681 3 p.

Research output: Contribution to journalArticle

17 Scopus citations

Nav1.3 sodium channels: Rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons

Cummins, T. R., Aglieco, F., Renganathan, M., Herzog, R. I., Dib-Hajj, S. D. & Waxman, S. G., Aug 15 2001, In : Journal of Neuroscience. 21, 16, p. 5952-5961 10 p.

Research output: Contribution to journalArticle

234 Scopus citations

On the mechanisms of neuroprotection by creatine and phosphocreatine

Brustovetsky, N., Brustovetsky, T. & Dubinsky, J. M., Feb 5 2001, In : Journal of Neurochemistry. 76, 2, p. 425-434 10 p.

Research output: Contribution to journalArticle

104 Scopus citations

Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons

Herzog, R. I., Cummins, T. R. & Waxman, S. G., Sep 26 2001, In : Journal of Neurophysiology. 86, 3, p. 1351-1364 14 p.

Research output: Contribution to journalArticle

222 Scopus citations

Phorbol ester-induced inhibition of potassium currents in rat sensory neurons requires voltage-dependent entry of calcium

Zhang, Y. H., Kenyon, J. L. & Nicol, G. D., Jan 31 2001, In : Journal of Neurophysiology. 85, 1, p. 362-373 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
153 Scopus citations

Seizure activity and hyperthermia potentiate the increases in dopamine and serotonin extracellular levels in the amygdala during exposure to d-amphetamine

Tor-Agbidye, J., Yamamoto, B. & Bowyer, J. F., Apr 2 2001, In : Toxicological Sciences. 60, 1, p. 103-111 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Sodium channel inactivation defects are associated with acetazolamide-exacerbated hypokalemic periodic paralysis

Bendahhou, S., Cummins, T. R., Griggs, R. C., Fu, Y. H. & Ptáek, L. J., Sep 26 2001, In : Annals of Neurology. 50, 3, p. 417-420 4 p.

Research output: Contribution to journalArticle

64 Scopus citations

Sodium currents of large (Aβ-type) adult cutaneous afferent dorsal root ganglion neurons display rapid recovery from inactivation before and after axotomy

Everill, B., Cummins, T. R., Waxman, S. G. & Kocsis, J. D., Sep 3 2001, In : Neuroscience. 106, 1, p. 161-169 9 p.

Research output: Contribution to journalArticle

46 Scopus citations
20 Scopus citations

Sucrase-isomaltase: An epithelial chloride channel? [1] (multiple letters)

Danielsen, E. M., Sjöström, H., Norén, O., Danielsen, G. M., Finn, A. L. & Oxford, G. S., Jan 1 2001, In : Gastroenterology. 121, 3, p. 741-742 2 p.

Research output: Contribution to journalArticle

Sucrase-isomaltase is and adenosine 3′, 5′-cyclic monophosphate-dependent epithelial chloride channel

Finn, A. L., Kuzhikandathil, E. V., Oxford, G. S. & Itoh-Lindstrom, Y., Jan 2001, In : Gastroenterology. 120, 1, p. 117-125 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines

Gangjee, A., Vidwans, A., Elzein, E., McGuire, J. J., Queener, S. F. & Kisliuk, R. L., Jun 7 2001, In : Journal of Medicinal Chemistry. 44, 12, p. 1993-2003 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

Synthesis of 2,4-Diamino-6-(thioarylmethyl)pyrido[2,3-d]pyrimidines as dihydrofolate reductase inhibitors

Gangjee, A., Adair, O. & Queener, S. F., Oct 9 2001, In : Bioorganic and Medicinal Chemistry. 9, 11, p. 2929-2935 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Synthesis of new 2, 4-diamino-7H-pyrrolo[2, 3-d]pyrimidines via the Taylor ring transformation/ring annulation strategy

Rosowsky, A., Fu, H. & Queener, S. F., Jan 1 2001, In : Journal of Heterocyclic Chemistry. 38, 5, p. 1197-1202 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
13 Scopus citations

Two subcellular localizations of eIF3 p170 and its interaction with membrane-bound microfilaments: Implications for alternative functions of p170

Pincheira, R., Chen, Q., Huang, Z. & Zhang, J. T., Jan 1 2001, In : European Journal of Cell Biology. 80, 6, p. 410-418 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Tyrosine augments acute clozapine- but not haloperidol-induced dopamine release in the Medial Prefrontal Cortex of the rat: An in vivo microdialysis study

Jaskiw, G. E., Collins, K. A., Pehek, E. A. & Yamamoto, B. K., Jun 11 2001, In : Neuropsychopharmacology. 25, 1, p. 149-156 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

β2-microglobulin induces apoptosis in HL-60 human leukemia cell line and its multidrug resistant variants overexpressing MRP1 but lacking Bax or overexpressing P-glycoprotein

Wu, C. H., Rastegar, M., Gordon, J. & Safa, A. R., Oct 25 2001, In : Oncogene. 20, 48, p. 7006-7020 15 p.

Research output: Contribution to journalArticle

24 Scopus citations
2000

A double mutation in families with periodic paralysis defines new aspects of sodium channel slow inactivation

Bendahhou, S., Cummins, T. R., Hahn, A. F., Langlois, S., Waxman, S. G. & Ptácek, L. J., Jan 1 2000, In : Journal of Clinical Investigation. 106, 3, p. 431-438 8 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Alterations in respiratory behavior, brain neurochemistry and receptor density induced by pharmacologic suppression of sleep in the neonatal period

Thomas, A. J., Erokwu, B. O., Yamamoto, B. K., Ernsberger, P., Bishara, O. & Strohl, K. P., Apr 14 2000, In : Developmental Brain Research. 120, 2, p. 181-189 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

A novel action of human apurinic/apyrimidinic endonuclease. Excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA

Chou, K. M., Kukhanova, M. & Cheng, Y. C., Oct 6 2000, In : Journal of Biological Chemistry. 275, 40, p. 31009-31015 7 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

Central administration of methamphetamine synergizes with metabolic inhibition to deplete striatal monoamines

Burrows, K. B., Nixdorf, W. L. & Yamamoto, B. K., Mar 1 2000, In : Journal of Pharmacology and Experimental Therapeutics. 292, 3, p. 853-860 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy

Sleeper, A. A., Cummins, T. R., Dib-Hajj, S. D., Hormuzdiar, W., Tyrrell, L., Waxman, S. G. & Black, J. A., Oct 1 2000, In : Journal of Neuroscience. 20, 19, p. 7279-7289 11 p.

Research output: Contribution to journalArticle

171 Scopus citations

Characterization and regulation of E2F activity during Caco-2 cell differentiation

Ding, Q., Wang, Q., Dong, Z. & Evers, B. M., Feb 29 2000, In : American Journal of Physiology - Cell Physiology. 278, 1 47-1, p. C110-C117

Research output: Contribution to journalArticle

7 Scopus citations
25 Scopus citations

Design, synthesis, and x-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent

Gangjee, A., Yu, J., McGuire, J. J., Cody, V., Galitsky, N., Kisliuk, R. L. & Queener, S. F., Oct 19 2000, In : Journal of Medicinal Chemistry. 43, 21, p. 3837-3851 15 p.

Research output: Contribution to journalArticle

72 Scopus citations

Determinant of the extracellular location of the N-terminus of human multidrug-resistance-associated protein

Zhang, J. T., Jun 15 2000, In : Biochemical Journal. 348, 3, p. 597-606 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Determination of mouse bladder inflammatory response to E. coli lipopolysaccharide

Jerde, T. J., Bjorling, D. E., Steinberg, H., Warner, T. & Saban, R., Jan 1 2000, In : Urological Research. 28, 4, p. 269-273 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Distribution of neuropeptides, histamine content, and inflammatory cells in the ureter

Jerde, T. J., Saban, R., Bjorling, D. E., Steinberg, H. & Nakada, S. Y., Jul 1 2000, In : Urology. 56, 1, p. 173-178 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Dominant-negative mutants identify a role for GIRK channels in D3 dopamine receptor-mediated regulation of spontaneous secretory activity

Kuzhikandathil, E. V. & Oxford, G. S., Jun 1 2000, In : Journal of General Physiology. 115, 6, p. 697-706 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Downregulation of mitogen-activated protein kinases in human colon cancers

Wang, Q., Ding, Q., Dong, Z., Ehlers, R. A. & Evers, B. M., Apr 18 2000, In : Anticancer Research. 20, 1 A, p. 75-83 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Dual responses of CNS mitochondria to elevated calcium

Brustovetsky, N. & Dubinsky, J. M., Jan 1 2000, In : Journal of Neuroscience. 20, 1, p. 103-113 11 p.

Research output: Contribution to journalArticle

115 Scopus citations

Effect of melatonin on phase I and II biotransformation enzymes in streptozotocin-induced diabetic rats

Maritim, A. C., Moore, B. H., Sanders, R. A. & Watkins, J. B., Jan 1 2000, In : International Journal of Toxicology. 19, 4, p. 277-283 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effects of aldose reductase inhibitors on antioxidant defense in rat and rabbit liver

Thomas, T., Rauscher, F., Sanders, R., Veltman, J. & Watkins, J. B., Jan 1 2000, In : Toxicological Sciences. 53, 1, p. 145-149 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effects of new antioxidant compounds PNU-104067F and PNU-74389G on antioxidant defense in normal and diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., Dec 1 2000, In : Journal of Biochemical and Molecular Toxicology. 14, 4, p. 189-194 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., Jan 1 2000, In : Journal of Biochemical and Molecular Toxicology. 14, 6, p. 329-334 6 p.

Research output: Contribution to journalArticle

72 Scopus citations

Genetic heterogeneity and molecular epidemiology of GB virus C/hepatitis G virus in China

An, P., Luo, H., Lu, T., O'Brien, S. J. & Winkler, C., Nov 25 2000, In : Journal of Human Virology. 3, 6, p. 299-305 7 p.

Research output: Contribution to journalArticle

Glial-derived neurotrophic factor upregulates expression of functional SNS and NaN sodium channels and their currents in axotomized dorsal root ganglion neurons

Cummins, T. R., Black, J. A., Dib-Hajj, S. D. & Waxman, S. G., Dec 1 2000, In : Journal of Neuroscience. 20, 23, p. 8754-8761 8 p.

Research output: Contribution to journalArticle

124 Scopus citations
46 Scopus citations
18 Scopus citations

Involvement of glutamate in transmission of afferent constrictive inputs from the airways to the nucleus tractus solitarius in ferrets

Haxhiu, M. A., Yamamoto, B., Dreshaj, I. A., Bedol, D. & Ferguson, D. G., Apr 12 2000, In : Journal of the Autonomic Nervous System. 80, 1-2, p. 22-30 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Ionophore-resistant mutants of Toxoplasma gondii reveal host cell permeabilization as an early event in egress

Black, M. W., Arrizabalaga, G. & Boothroyd, J. C., Dec 1 2000, In : Molecular and cellular biology. 20, 24, p. 9399-9408 10 p.

Research output: Contribution to journalArticle

100 Scopus citations

Irinotecan in the management of patients with pancreatic cancer

Green, M. R., Harper, M., Safa, A., Sherman, C. A., Mushtaq, C. M., Bahadori, H., Brescia, F. J. & Rocha Lima, C. M. S. P., Dec 1 2000, In : ONCOLOGY. 14, 12 SUPPL. 14, p. 31-33 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons

Evans, A. R., Junger, H., Southall, M. D., Nicol, G. D., Sorkin, L. S., Broome, J. T., Bailey, T. W. & Vasko, M. R., Jun 1 2000, In : Journal of Pharmacology and Experimental Therapeutics. 293, 3, p. 912-920 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Limitations of cyclosporin A inhibition of the permeability transition in CNS mitochondria

Brustovetsky, N. & Dubinsky, J. M., Nov 15 2000, In : Journal of Neuroscience. 20, 22, p. 8229-8237 9 p.

Research output: Contribution to journalArticle

141 Scopus citations

Methamphetamine selectively alters brain glutathione

Harold, C., Wallace, T., Friedman, R., Gudelsky, G. & Yamamoto, B., Jul 14 2000, In : European Journal of Pharmacology. 400, 1, p. 99-102 4 p.

Research output: Contribution to journalArticle

44 Scopus citations

Nitric oxide is an autocrine regulator of Na+ currents in axotomized C- type DRG neurons

Renganathan, M., Cummins, T. R., Hormuzdiar, W. N., Black, J. A. & Waxman, S. G., Apr 20 2000, In : Journal of Neurophysiology. 83, 4, p. 2431-2442 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Prostaglandin E2-mediated sensitization of rat sensory neurons is not altered by nerve growth factor

Southall, M. D. & Vasko, M. R., Jun 16 2000, In : Neuroscience Letters. 287, 1, p. 33-36 4 p.

Research output: Contribution to journalArticle

30 Scopus citations

Rapid and transient inhibition of mitochondrial function following methamphetamine or 3,4-methylenedioxymethamphetamine administration

Burrows, K. B., Gudelsky, G. & Yamamoto, B. K., Jun 9 2000, In : European Journal of Pharmacology. 398, 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

112 Scopus citations