Pharmacology & Toxicology

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1995

GBR-12909-induced self-injurious behavior: role of dopamine

Sivam, S. P., Sep 4 1995, In : Brain research. 690, 2, p. 259-263 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Integration of pharmacology into a problem–based learning curriculum for medical students

Sivam, S. P., Iatridis, P. G. & Vaughn, S., Jul 1995, In : Medical Education. 29, 4, p. 289-296 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Involvement of Cytoplasmic Factors Regulating the Membrane Orientation of P-Glycoprotein Sequences

Zhang, J. T. & Ling, V., Jul 1995, In : Biochemistry. 34, 28, p. 9159-9165 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Minimal effects of two aldose reductase inhibitors, AL-1576 and AL-4114, after subacute topical-ocular dosing on xenobiotic biotransformation in rabbits

Sastry, S. G., Sanders, R. A., Veltman, J. C. & Watkins, J. B., Jan 1 1995, In : Drug Metabolism and Disposition. 23, 10, p. 1094-1098 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

New Drug Developments for Opportunistic Infections in Immunosuppressed Patients: Pneumocystis carnii

Queener, S. F., Nov 1 1995, In : Journal of Medicinal Chemistry. 38, 24, p. 4739-4759 21 p.

Research output: Contribution to journalArticle

73 Scopus citations

Nonclassical 2,4-Diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline Antifolates: Synthesis and Biological Activities

Gangjee, A., Zaveri, N., Kothare, M. & Queener, S. F., Sep 1 1995, In : Journal of Medicinal Chemistry. 38, 18, p. 3660-3668 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Novel 2, 4-Diamino-5-Substituted-pyrrolo[2, 3-d]pyrimidines as Classical and Nonclassical Antifolate Inhibitors of Dihydrofolate Reductases

Gangjee, A., Mavandadi, F., Queener, S. F. & McGuire, J. J., Jun 1 1995, In : Journal of Medicinal Chemistry. 38, 12, p. 2158-2165 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Prostaglandin-induced neuropeptide release from spinal cord

Vasko, M. R., Jan 1 1995, In : Progress in Brain Research. 104, C, p. 367-380 14 p.

Research output: Contribution to journalArticle

95 Scopus citations

Prostaglandins facilitate peptide release from rat sensory neurons by activating the adenosine 3',5'-cyclic monophosphate transduction cascade

Hingtgen, C. M., Waite, K. J. & Vasko, M. R., 1995, In : Journal of Neuroscience. 15, 7 II, p. 5411-5419 9 p.

Research output: Contribution to journalArticle

Open Access
186 Scopus citations

Pteroylpolyglutamate synthesis by lung- and culture-derived Pneumocystis carinii

Hong, Y. L., Bartlett, M. S., Queener, S., Smith, J. W., Shaw, M. & Meshnick, S. R., Dec 15 1995, In : FEMS Microbiology Letters. 134, 2-3, p. 251-254 4 p.

Research output: Contribution to journalArticle

Serine-1321-independent regulation of the μ1 adult skeletal muscle Na+ channel by protein kinase C

Bendahhou, S., Cummins, T. R., Potts, J. F., Tong, J. & Agnew, W. S., Dec 19 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 26, p. 12003-12007 5 p.

Research output: Contribution to journalArticle

53 Scopus citations
11 Scopus citations
79 Scopus citations

Synthesis and biological activities of tetrahydroquinazoline analogs of aminopterin and methotrexate

Gangjee, A., Zaveri, N., Queener, S. F. & Kisliuk, R. L., Jan 1 1995, In : Journal of Heterocyclic Chemistry. 32, 1, p. 243-247 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Topological determinants of internal transmembrane segments in P- glycoprotein sequences

Zhang, J. T., Chow Hwee Lee, H. L., Duthie, M. & Ling, V., Jan 1 1995, In : Journal of Biological Chemistry. 270, 4, p. 1742-1746 5 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations
1994

2,4-Diamino-5-chloroquinazoline Analogs of Trimetrexate and Piritrexim: Synthesis and Antifolate Activity

Rosowsky, A., Mota, C. E., Wright, J. E. & Queener, S. F., Dec 1 1994, In : Journal of Medicinal Chemistry. 37, 26, p. 4522-4528 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Absence of coupling between D2 dopamine receptors and calcium channels in lactotrophs from cycling female rats

Rendt, J. & Oxford, G. S., Aug 1994, In : Endocrinology. 135, 2, p. 501-508 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Albendazole inhibits Pneumocystis carinii proliferation in inoculated immunosuppressed mice

Bartlett, M. S., Edlind, T. D., Lee, C. H., Dean, R., Queener, S. F., Shaw, M. M. & Smith, J. W., Jan 1 1994, In : Antimicrobial Agents and Chemotherapy. 38, 8, p. 1834-1837 4 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Carba prostacyclin enhances the capsaicin-induced cobalt-loading of rat sensory neurons grown in culture

Hingtgen, C. M. & Nicol, G. D., May 23 1994, In : Neuroscience Letters. 173, 1-2, p. 99-102 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Chronic voluntary exercise may alter hepatobiliary clearance of endogenous and exogenous chemicals in rats

Watkins, J. B., Crawford, S. T. & Sanders, R. A., Jan 1 1994, In : Drug Metabolism and Disposition. 22, 4, p. 537-543 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Classical and Nonclassical Furo[2,3-d]pyrimidines as Novel Antifolates: Synthesis and Biological Activities

Gangjee, A., Devraj, R., McGuire, J. J., Kisliuk, R. L., Queener, S. F. & Barrows, L. R., Apr 1 1994, In : Journal of Medicinal Chemistry. 37, 8, p. 1169-1176 8 p.

Research output: Contribution to journalArticle

81 Scopus citations

Comparison of corticosteroid- and L3T4+ antibody-immunosuppressed mouse models of Pneumocystis carinii pneumonia for evaluation of drugs and leukocytes

Bartlett, M. S., Current, W. L., Orazi, A., Bauer, N. L., Neiman, R. S., Queener, S. F. & Smith, J. W., Sep 1 1994, In : Clinical and Diagnostic Laboratory Immunology. 1, 5, p. 511-516 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Endothelin-1 enhances capsaicin-induced peptide release and cGMP accumulation in cultures of rat sensory neurons

Dymshitz, J. & Vasko, M. R., Feb 14 1994, In : Neuroscience Letters. 167, 1-2, p. 128-132 5 p.

Research output: Contribution to journalArticle

45 Scopus citations

Enhancement by prostaglandin E2 of bradykinin activation of embryonic rat sensory neurones.

Nicol, G. D. & Cui, M., Nov 1 1994, In : The Journal of Physiology. 480, 3, p. 485-492 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Incorporation of Fatty Acids and Amino Acids by Cultured Pneumocystis carinii

PAULSRUD, JOHN. R. & QUEENER, SHERRY. F., Nov 1994, In : Journal of Eukaryotic Microbiology. 41, 6, p. 633-638 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mechanisms of Assembly of the Enzyme‐ssDNA Complexes Required for Recombination‐Dependent DNA Synthesis and Repair in Bacteriophage T4

MORRICAL, SCOTT., HEMPSTEAD, KEN., MORRICAL, MILA., CHOU, KAIMING. M., ANDO, RICK. & GRIGORIEVA, OLGA., Jul 1994, In : Annals of the New York Academy of Sciences. 726, 1, p. 349-350 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

Modulation of P-Glycoprotein by Protein Kinase Cα in a Baculovirus Expression System

Ahmad, S., Glazer, R. I. & Safa, A. R., Aug 1 1994, In : Biochemistry. 33, 34, p. 10313-10318 6 p.

Research output: Contribution to journalArticle

66 Scopus citations

Nitric oxide and cyclic guanosine 3',5'-monophosphate do not alter neuropeptide release from rat sensory neurons grown in culture

Dymshitz, J. & Vasko, M. R., Oct 1994, In : Neuroscience. 62, 4, p. 1279-1286 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Paracetamol Pharmacokinetics are Independent of Caloric Intake and Physical Activity

Yiamouyiannis, C. A., Harris, A., Sanders, R. A., Martin, B. J. & Watkins, J. B., Dec 1994, In : Drug Investigation. 8, 6, p. 361-368 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Prostacyclin enhances the evoked-release of substance P and calcitonin gene-related peptide from rat sensory neurons

Hingtgen, C. M. & Vasko, M. R., Aug 29 1994, In : Brain research. 655, 1-2, p. 51-60 10 p.

Research output: Contribution to journalArticle

92 Scopus citations

Prostaglandin E2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture

Vasko, M. R., Campbell, W. B. & Waite, K. J., Aug 1994, In : Journal of Neuroscience. 14, 8, p. 4987-4997 11 p.

Research output: Contribution to journalArticle

Open Access
190 Scopus citations

Simultaneous determination of primaquine and carboxyprimaquine in plasma using high-performance liquid chromatography with electrochemical detection

Dean, R. A., Ochieng, W., Black, J., Queener, S. F., Bartlett, M. S. & Dumaual, N. G., Apr 22 1994, In : Journal of Chromatography B: Biomedical Sciences and Applications. 655, 1, p. 89-96 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

The phosphatase inhibitor, okadaic acid, increases peptide release from rat sensory neurons in culture

Hingtgen, C. M. & Vasko, M. R., Aug 29 1994, In : Neuroscience Letters. 178, 1, p. 135-138 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

The topological structure of connexin 26 and its distribution compared to connexin 32 in hepatic gap junctions

Zhang, J. T. & Nicholson, B. J., Apr 1 1994, In : The Journal of Membrane Biology. 139, 1, p. 15-29 15 p.

Research output: Contribution to journalArticle

65 Scopus citations

Typing of Pneumocystis carinii strains that infect humans based on nucleotide sequence variations of internal transcribed spacers of rRNA genes

Lu, J. J., Bartlett, M. S., Shaw, M. M., Queener, S. F., Smith, J. W., Rivera, M. O., Leibowitz, M. J. & Chao Hung Lee, H. L., 1994, In : Journal of clinical microbiology. 32, 12, p. 2904-2912 9 p.

Research output: Contribution to journalArticle

Open Access
104 Scopus citations
1993

2,4-Diaminothieno[2,3-d]pyrimidine Analogues of Trimetrexate and Piritrexim as Potential Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase

Rosowsky, A., Mota, C. E., Wright, J. E., Freisheim, J. H., Heusner, J. J., McCormack, J. J. & Queener, S. F., Jan 1 1993, In : Journal of Medicinal Chemistry. 36, 21, p. 3103-3112 10 p.

Research output: Contribution to journalArticle

68 Scopus citations

8-Aminoquinolines effective against Pneumocystis carinii in vitro and in vivo

Queener, S. F., Bartlett, M. S., Nasr, M. & Smith, J. W., Jan 1 1993, In : Antimicrobial Agents and Chemotherapy. 37, 10, p. 2166-2172 7 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Alcohol‐Induced Inhibition of Alveolar Macrophage Oxidant Release in Vivo and in Vitro

Antony, V. B., Godbey, S. W., Hott, J. W. & Queener, S. F., Apr 1993, In : Alcoholism: Clinical and Experimental Research. 17, 2, p. 389-393 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Amylin modulates β-cell glucose sensing via effects on stimulus-secretion coupling

Wagoner, P. K., Chen, C., Worley, J. F., Dukes, I. D. & Oxford, G. S., Oct 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 19, p. 9145-9149 5 p.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations

Chronic physical activity alters hepatobiliary excretory function in rats

Yiamouyiannis, C. A., Martin, B. J. & Watkins, J. B., Jan 1 1993, In : Journal of Pharmacology and Experimental Therapeutics. 265, 1, p. 321-327 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Differential expression of P‐glycoprotein genes in primary rat hepatocyte culture

Lee, C. H., Bradley, G., Zhang, JT. T. & Ling, V., Nov 1993, In : Journal of cellular physiology. 157, 2, p. 392-402 11 p.

Research output: Contribution to journalArticle

75 Scopus citations

Effect of sodium orthovanadate on the hepatobiliary clearance of rose bengal in streptozotocin-induced diabetic rats

Watkins, J. B., Bauman, M. E. & Beaty, T. M., Dec 14 1993, In : Biochemical Pharmacology. 46, 12, p. 2269-2276 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effects of 8-aminoquinolines on the ultrastructural morphology of Pneumocystis carinii

Goheen, M. P., Bartlett, M. S., Shaw, M. M., Queener, S. F. & Smith, J. W., Aug 31 1993, In : International Journal of Experimental Pathology. 74, 4, p. 379-387 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Guanine nucleotide binding proteins mediate D2 dopamine receptor activation of a potassium channel in rat lactotrophs.

Einhorn, L. C. & Oxford, G. S., Mar 1 1993, In : The Journal of Physiology. 462, 1, p. 563-578 16 p.

Research output: Contribution to journalArticle

34 Scopus citations

Identification of highly potent and selective inhibitors of Toxoplasma gondii dihydrofolate reductase

Chio, L. C. & Queener, S. F., 1993, In : Antimicrobial Agents and Chemotherapy. 37, 9, p. 1914-1923 10 p.

Research output: Contribution to journalArticle

Open Access
92 Scopus citations
5 Scopus citations

Membrane orientation of transmembrane segments 11 and 12 of MDR- and non-MDR-associated P-glycoproteins

Zhang, J. T. & Ling, V., Dec 12 1993, In : BBA - Biomembranes. 1153, 2, p. 191-202 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Membrane topology of the N-terminal half of the hamster P-glycoprotein molecule

Zhang, J. T., Duthie, M. & Ling, V., Jul 29 1993, In : Journal of Biological Chemistry. 268, 20, p. 15101-15110 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

Modulation of ion channels underlying excitation-secretion coupling in identified lactotrophs and gonadotrophs

Oxford, G. S. & Tse, A., Jan 5 1993, In : Biology of Reproduction. 48, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Synthesis of 5-Methyl-5-deaza Nonclassical Antifolates as Inhibitors of Dihydrofolate Reductases and as Potential Antipneumocystis, Antitoxoplasma, and Antitumor Agents

Gangjee, A., Shi, J., Queener, S. F., Barrows, L. R. & Kisliuk, R. L., Jan 1 1993, In : Journal of Medicinal Chemistry. 36, 22, p. 3437-3443 7 p.

Research output: Contribution to journalArticle

42 Scopus citations