Pharmacology & Toxicology

Publications 1971 2020

Filter
Article
1995
187 Citations (Scopus)

Prostaglandins facilitate peptide release from rat sensory neurons by activating the adenosine 3′,5′-cyclic monophosphate transduction cascade

Hingtgen, C. M., Waite, K. J. & Vasko, M., Jul 1995, In : Journal of Neuroscience. 15, 7 I, p. 5411-5419 9 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Adenosine
Prostaglandins
Peptides
Calcitonin Gene-Related Peptide

Pteroylpolyglutamate synthesis by lung- and culture-derived Pneumocystis carinii

Hong, Y. L., Bartlett, M. S., Queener, S., Smith, J. W., Shaw, M. & Meshnick, S. R., Dec 15 1995, In : FEMS Microbiology Letters. 134, 2-3, p. 251-254 4 p.

Research output: Contribution to journalArticle

Pteroylpolyglutamic Acids
Pneumocystis carinii
4-Aminobenzoic Acid
Lung
Folic Acid
11 Citations (Scopus)
Corpus Striatum
Dynorphins
Fluoxetine
Serotonin Uptake Inhibitors
Substance P
73 Citations (Scopus)
Trimetrexate
Folic Acid Antagonists
Enzymes
Rats
Trimethoprim
6 Citations (Scopus)

Synthesis and biological activities of tetrahydroquinazoline analogs of aminopterin and methotrexate

Gangjee, A., Zaveri, N., Queener, S. & Kisliuk, R. L., 1995, In : Journal of Heterocyclic Chemistry. 32, 1, p. 243-247 5 p.

Research output: Contribution to journalArticle

Aminopterin
Bioactivity
Aldehydes
Methotrexate
Folic Acid Antagonists
1994
44 Citations (Scopus)

2,4-diamino-5-chloroquinazoline analogues of trimetrexate and piritrexim: Synthesis and antifolate activity

Rosowsky, A., Mota, C. E., Wright, J. E. & Queener, S., 1994, In : Journal of Medicinal Chemistry. 37, 26, p. 4522-4528 7 p.

Research output: Contribution to journalArticle

Trimetrexate
Quinazolines
Folic Acid Antagonists
Toxoplasma
Tetrahydrofolate Dehydrogenase
20 Citations (Scopus)

Albendazole inhibits Pneumocystis carinii proliferation in inoculated immunosuppressed mice

Bartlett, M. S., Edlind, T. D., Lee, C-H., Dean, R., Queener, S., Shaw, M. M. & Smith, J. W., 1994, In : Antimicrobial Agents and Chemotherapy. 38, 8, p. 1834-1837 4 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Albendazole
Pneumocystis Infections
Pneumocystis Pneumonia
Helminths
2 Citations (Scopus)

Carba prostacyclin enhances the capsaicin-induced cobalt-loading of rat sensory neurons grown in culture

Hingtgen, C. M. & Nicol, G., May 23 1994, In : Neuroscience Letters. 173, 1-2, p. 99-102 4 p.

Research output: Contribution to journalArticle

Capsaicin
Sensory Receptor Cells
Cobalt
Neurons
Spinal Ganglia
16 Citations (Scopus)

Chronic voluntary exercise may alter hepatobiliary clearance of endogenous and exogenous chemicals in rats

Watkins, J. B., Crawford, S. T. & Sanders, R. A., 1994, In : Drug Metabolism and Disposition. 22, 4, p. 537-543 7 p.

Research output: Contribution to journalArticle

Rats
Bile Acids and Salts
Acetaminophen
Rose Bengal
Liver
81 Citations (Scopus)

Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: Synthesis and biological activities

Gangjee, A., Devraj, R., McGuire, J. J., Kisliuk, R. L., Queener, S. & Barrows, L. R., 1994, In : Journal of Medicinal Chemistry. 37, 8, p. 1169-1176 8 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pyrimidines
Hydroxymethyl and Formyl Transferases
Bioactivity
Methotrexate
16 Citations (Scopus)

Comparison of corticosteroid- and L3T4+ antibody-immunosuppressed mouse models of Pneumocystis carinii pneumonia for evaluation of drugs and leukocytes

Bartlett, M. S., Current, W. L., Orazi, A., Bauer, N. L., Neiman, R. S., Queener, S. & Smith, J. W., Sep 1994, In : Clinical and Diagnostic Laboratory Immunology. 1, 5, p. 511-516 6 p.

Research output: Contribution to journalArticle

T Lymphocyte Differentiation Antigens
Inbred BALB C Mouse
Animal Disease Models
Pneumocystis carinii
Drug Evaluation
44 Citations (Scopus)

Endothelin-1 enhances capsaicin-induced peptide release and cGMP accumulation in cultures of rat sensory neurons

Dymshitz, J. & Vasko, M., Feb 14 1994, In : Neuroscience Letters. 167, 1-2, p. 128-132 5 p.

Research output: Contribution to journalArticle

Capsaicin
Endothelin-1
Sensory Receptor Cells
Peptides
Calcitonin Gene-Related Peptide
71 Citations (Scopus)

Enhancement by prostaglandin E2 of bradykinin activation of embryonic rat sensory neurones

Nicol, G. & Cui, M., 1994, In : Journal of Physiology. 480, 3, p. 485-492 8 p.

Research output: Contribution to journalArticle

Bradykinin
Sensory Receptor Cells
Dinoprostone
Action Potentials
Membrane Potentials
17 Citations (Scopus)

Incorporation of fatty acids and amino acids by cultured Pneumocystis carinii

Paulsrud, J. R. & Queener, S., Nov 1994, In : Journal of Eukaryotic Microbiology. 41, 6, p. 633-638 6 p.

Research output: Contribution to journalArticle

Biological Transport
Primaquine
Pneumocystis carinii
Fungal Proteins
Membrane Glycoproteins
19 Citations (Scopus)

Nitric oxide and cyclic guanosine 3',5'-monophosphate do not alter neuropeptide release from rat sensory neurons grown in culture

Dymshitz, J. & Vasko, M., 1994, In : Neuroscience. 62, 4, p. 1279-1286 8 p.

Research output: Contribution to journalArticle

Guanosine Monophosphate
Cyclic GMP
Sensory Receptor Cells
Neuropeptides
Capsaicin
3 Citations (Scopus)

Paracetamol pharmacokinetics are independent of caloric intake and physical activity

Yiamouyiannis, C. A., Harris, A., Sanders, R. A., Martin, B. J. & Watkins, J. B., 1994, In : Drug Investigation. 8, 6, p. 361-368 8 p.

Research output: Contribution to journalArticle

Acetaminophen
Energy Intake
Pharmacokinetics
Exercise
Volunteers
36 Citations (Scopus)

Pneumocystis carinii is resistant to imidazole antifungal agents

Bartlett, M. S., Queener, S., Shaw, M. M., Richardson, J. D. & Smith, J. W., 1994, In : Antimicrobial Agents and Chemotherapy. 38, 8, p. 1859-1861 3 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Antifungal Agents
Imidazoles
Miconazole
Ergosterol
91 Citations (Scopus)

Prostacyclin enhances the evoked-release of substance P and calcitonin gene-related peptide from rat sensory neurons

Hingtgen, C. M. & Vasko, M., Aug 29 1994, In : Brain Research. 655, 1-2, p. 51-60 10 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
Sensory Receptor Cells
Epoprostenol
Substance P
Capsaicin
189 Citations (Scopus)

Prostaglandin E2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture

Vasko, M., Campbell, W. B. & Waite, K. J., Aug 1994, In : Journal of Neuroscience. 14, 8, p. 4987-4997 11 p.

Research output: Contribution to journalArticle

Bradykinin
Sensory Receptor Cells
Neuropeptides
Dinoprostone
Prostaglandins
94 Citations (Scopus)

Prostaglandin-induced neuropeptide release from spinal cord

Vasko, M., 1994, In : Progress in Brain Research. 104, p. 367-380 14 p.

Research output: Contribution to journalArticle

Neuropeptides
Prostaglandins
Spinal Cord
Sensory Receptor Cells
Eicosanoids
14 Citations (Scopus)

Simultaneous determination of primaquine and carboxyprimaquine in plasma using high-performance liquid chromatography with electrochemical detection

Dean, R. A., Ochieng, W., Black, J., Queener, S., Bartlett, M. S. & Dumaual, N. G., Apr 22 1994, In : Journal of Chromatography B: Biomedical Sciences and Applications. 655, 1, p. 89-96 8 p.

Research output: Contribution to journalArticle

Primaquine
High performance liquid chromatography
Plasmas
Pharmacokinetics
Metabolites
20 Citations (Scopus)

The phosphatase inhibitor, okadaic acid, increases peptide release from rat sensory neurons in culture

Hingtgen, C. M. & Vasko, M., Aug 29 1994, In : Neuroscience Letters. 178, 1, p. 135-138 4 p.

Research output: Contribution to journalArticle

Okadaic Acid
Sensory Receptor Cells
Phosphoric Monoester Hydrolases
Peptides
Calcitonin Gene-Related Peptide
103 Citations (Scopus)

Typing of Pneumocystis carinii strains that infect humans based on nucleotide sequence variations of internal transcribed spacers of rRNA genes

Lu, J. J., Bartlett, M. S., Shaw, M. M., Queener, S., Smith, J. W., Rivera, M. O., Leibowitz, M. J. & Chao Hung Lee, H. L., 1994, In : Journal of Clinical Microbiology. 32, 12, p. 2904-2912 9 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
rRNA Genes
Coinfection
1993
68 Citations (Scopus)

2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Rosowsky, A., Mota, C. E., Wright, J. E., Freisheim, J. H., Heusner, J. J., McCormack, J. J. & Queener, S., 1993, In : Journal of Medicinal Chemistry. 36, 21, p. 3103-3112 10 p.

Research output: Contribution to journalArticle

Trimetrexate
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
Liver
30 Citations (Scopus)

8-Aminoquinolines effective against Pneumocystis carinii in vitro and in vivo

Queener, S., Bartlett, M. S., Nasr, M. & Smith, J. W., 1993, In : Antimicrobial Agents and Chemotherapy. 37, 10, p. 2166-2172 7 p.

Research output: Contribution to journalArticle

Primaquine
Pneumocystis carinii
Pneumocystis Pneumonia
Drinking Water
Nitrogen
26 Citations (Scopus)

Alcohol-induced inhibition of alveolar macrophage oxidant release in vivo and in vitro

Antony, V. B., Godbey, S. W., Hott, J. W. & Queener, S., 1993, In : Alcoholism: Clinical and Experimental Research. 17, 2, p. 389-393 5 p.

Research output: Contribution to journalArticle

Alveolar Macrophages
Oxidants
Alcohols
Superoxides
Rats
19 Citations (Scopus)

Chronic physical activity alters hepatobiliary excretory function in rats

Yiamouyiannis, C. A., Martin, B. J. & Watkins, J. B., 1993, In : Journal of Pharmacology and Experimental Therapeutics. 265, 1, p. 321-327 7 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Anions
Cations
Antipyrine
Aminopyrine
3 Citations (Scopus)

Effect of sodium orthovanadate on the hepatobiliary clearance of rose bengal in streptozotocin-induced diabetic rats

Watkins, J. B., Bauman, M. E. & Beaty, T. M., Dec 14 1993, In : Biochemical Pharmacology. 46, 12, p. 2269-2276 8 p.

Research output: Contribution to journalArticle

Rose Bengal
Vanadates
Streptozocin
Rats
Sodium
8 Citations (Scopus)

Effects of 8-aminoquinolines on the ultrastructural morphology of Pneumocystis carinii

Goheen, M. P., Bartlett, M. S., Shaw, M. M., Queener, S. & Smith, J. W., 1993, In : International Journal of Experimental Pathology. 74, 4, p. 379-387 9 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Primaquine
Trophozoites
Nuclear Envelope
8-aminoquinoline
92 Citations (Scopus)

Identification of highly potent and selective inhibitors of Toxoplasma gondii dihydrofolate reductase

Chio, L. C. & Queener, S., 1993, In : Antimicrobial Agents and Chemotherapy. 37, 9, p. 1914-1923 10 p.

Research output: Contribution to journalArticle

Pyrimethamine
Tetrahydrofolate Dehydrogenase
Toxoplasma
Trimetrexate
Inhibitory Concentration 50
5 Citations (Scopus)
Clorgyline
Selegiline
Dynorphins
Monoamine Oxidase Inhibitors
Monoamine Oxidase
31 Citations (Scopus)

Proliferation of rat Pneumocystis carinii on cells sheeted on microcarrier beads in spinner flasks

Lee, C-H., Bauer, N. L., Shaw, M. M., Durkin, M. M., Bartlett, M. S., Queener, S. & Smith, J. W., 1993, In : Journal of Clinical Microbiology. 31, 6, p. 1659-1662 4 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Trophozoites
Fibroblasts
Antigens
Lung
30 Citations (Scopus)

Prostaglandins stimulate the release of substance P from rat spinal cord slices

Vasko, M., Zirkelbach, S. L. & Waite, K. J., 1993, In : Progress in Pharmacology and Clinical Pharmacology. 10, 1, p. 69-89 21 p.

Research output: Contribution to journalArticle

Substance P
Prostaglandins
Spinal Cord
42 Citations (Scopus)

Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents

Gangjee, A., Shi, J., Queener, S., Barrows, L. R. & Kisliuk, R. L., 1993, In : Journal of Medicinal Chemistry. 36, 22, p. 3437-3443 7 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Toxoplasma
Antineoplastic Agents
Pneumocystis carinii
22 Citations (Scopus)
Pimozide
Retinal Rod Photoreceptor Cells
Cyclic GMP
Calcium Channel Blockers
Pharmacology
11 Citations (Scopus)

Total cellular fatty acid composition of cultured Pneumocystis carinii

Paulsrud, J. R., Queener, S., Bartlett, M. S. & Smith, J. W., 1993, In : Journal of Clinical Microbiology. 31, 7, p. 1899-1902 4 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Oleic Acid
Fatty Acids
Trophozoites
Surface-Active Agents
1992
5 Citations (Scopus)

An enzyme-linked immunosorbent assay for enumeration of Pneumocystis carinii in vitro and in vivo

Durkin, M. M., Bartlett, M. S., Queener, S., Shaw, M. M., Lee, C-H. & Smith, J. W., 1992, In : Journal of Clinical Microbiology. 30, 12, p. 3258-3262 5 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Enzyme-Linked Immunosorbent Assay
Antibodies
Lung
In Vitro Techniques
30 Citations (Scopus)

Antimicrotubule benzimidazoles inhibit in vitro growth of Pneumocystis carinii

Bartlett, M. S., Edlind, T. D., Durkin, M. M., Shaw, M. M., Queener, S. & Smith, J. W., 1992, In : Antimicrobial Agents and Chemotherapy. 36, 4, p. 779-782 4 p.

Research output: Contribution to journalArticle

Benzimidazoles
Pneumocystis carinii
Thiabendazole
Structure-Activity Relationship
Growth
3 Citations (Scopus)

Biotransformation in carcinogen-induced diploid and polyploid hepatocytes separated by centrifugal elutriation

Watkins, J. B., Thierau, D. & Schwarz, L. R., 1992, In : Cancer Research. 52, 5, p. 1149-1154 6 p.

Research output: Contribution to journalArticle

Polyploidy
Biotransformation
Diploidy
Carcinogens
Hepatocytes
13 Citations (Scopus)

Chronic physical activity: Hepatic hypertrophy and increased total biotransformation enzyme activity

Yiamouyiannis, C. A., Sanders, R. A., Watkins, J. B. & Martin, B. J., Jul 7 1992, In : Biochemical Pharmacology. 44, 1, p. 121-127 7 p.

Research output: Contribution to journalArticle

Enzyme activity
Biotransformation
Liver
Hypertrophy
Rats
18 Citations (Scopus)

Efficacy of intermittent dosage of 8-aminoquinolines for therapy or prophylaxis of Pneumocystis pneumonia in rats

Queener, S., Dean, R. A., Bartlett, M. S., Milhous, W. K., Berman, J. D., Ellis, W. Y. & Smith, J. W., Apr 1992, In : Journal of Infectious Diseases. 165, 4, p. 764-768 5 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Primaquine
Therapeutics
Sulfamethoxazole Drug Combination Trimethoprim
8-aminoquinoline
23 Citations (Scopus)

Inoculated mouse model of Pneumocystis carinii infection

Bartlett, M. S., Queener, S., Durkin, M. M., Shaw, M. A. & Smith, J. W., 1992, In : Diagnostic Microbiology and Infectious Disease. 15, 2, p. 129-134 6 p.

Research output: Contribution to journalArticle

Pneumocystis Infections
Pneumocystis
Pneumocystis carinii
Sulfamethoxazole Drug Combination Trimethoprim
Costs and Cost Analysis
46 Citations (Scopus)

Long-term diabetes alters the hepatobiliary clearance of acetaminophen, bilirubin and digoxin

Watkins, J. B. & Sherman, S. E., 1992, In : Journal of Pharmacology and Experimental Therapeutics. 260, 3, p. 1337-1343 7 p.

Research output: Contribution to journalArticle

Digoxin
Acetaminophen
Bilirubin
Insulin
Half-Life
Neuropeptides
Cysteine
Neurotransmitter Agents
Rats
dynorphin (1-8)
173 Citations (Scopus)

Prostaglandin E2 increases calcium conductance and stimulates release of substance P in avian sensory neurons

Nicol, G., Klingberg, D. K. & Vasko, M., 1992, In : Journal of Neuroscience. 12, 5, p. 1917-1927 11 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Substance P
Dinoprostone
Calcium
Prostaglandins
27 Citations (Scopus)
Neurokinin-1 Receptors
Tachykinins
Capsaicin
Spinal Ganglia
Substance P
12 Citations (Scopus)
Vecuronium Bromide
Taurocholic Acid
Polyploidy
Ouabain
Diploidy
1991
32 Citations (Scopus)

8-Aminoquinolines from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystis pneumonia in rat models

Bartlett, M. S., Queener, S., Tidwell, R. R., Milhous, W. K., Berman, J. D., Ellis, W. Y. & Smith, J. W., 1991, In : Antimicrobial Agents and Chemotherapy. 35, 2, p. 277-282 6 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Primaquine
Pneumocystis carinii
Sulfamethoxazole Drug Combination Trimethoprim
8-aminoquinoline
70 Citations (Scopus)

A controlled trial of the cost benefit of computerized bayesian aminoglycosde administration

Burton, M. E., Ash, C. L., Hill, D. P., Handy, T., Shepherd, M. D. & Vasko, M., Jun 1991, In : Clinical Pharmacology and Therapeutics. 49, 6, p. 685-694 10 p.

Research output: Contribution to journalArticle

Cost-Benefit Analysis
Length of Stay
Control Groups
Cost Savings
Multivariate Analysis
1 Citation (Scopus)

An ELISA method for quantitation of Pneumocystis carinii in culture and lung.

Durkin, M. M., Bartlett, M. S., Queener, S., Shaw, M. M., Lee, C-H. & Smith, J. W., Nov 1991, In : Journal of Protozoology. 38, 6

Research output: Contribution to journalArticle

Pneumocystis carinii
Enzyme-Linked Immunosorbent Assay
Lung
Azure Stains
Goats