Pharmacology & Toxicology

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2016

FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1

Wu, X., Dong, Z., Wang, C. J., Barlow, L. J., Fako, V., Serrano, M. A., Zou, Y., Liu, J. Y. & Zhang, J. T., Nov 8 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 45, p. E6965-E6973

Research output: Contribution to journalArticle

18 Scopus citations

Garcinol inhibits GCN5-mediated lysine acetyltransferase activity and prevents replication of the parasite Toxoplasma gondii

Jeffers, V., Gao, H., Checkley, L. A., Liu, Y., Ferdig, M. T. & Sullivan, W. J., Apr 2016, In : Antimicrobial Agents and Chemotherapy. 60, 4, p. 2164-2170 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Glucose-independent acetate metabolism promotes melanoma cell survival and tumor growth

Lakhter, A. J., Hamilton, J., Konger, R., Broustovetski, N., Broxmeyer, H. & Naidu, S., Oct 14 2016, In : Journal of Biological Chemistry. 291, 42, p. 21869-21879 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
22 Scopus citations
3 Scopus citations

MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate

Huff, C. L., Morano, R. L., Herman, J. P., Yamamoto, B. K. & Gudelsky, G. A., Dec 1 2016, In : NeuroToxicology. 57, p. 282-290 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Meet our editorial board member

Sheets, P., 2016, In : Current Drug Targets. 17, 3, p. 253 1 p.

Research output: Contribution to journalArticle

Membrane patches as ion channel probes for scanning ion conductance microscopy

Shi, W., Zeng, Y., Zhou, L., Xiao, Y., Cummins, T. R. & Baker, L. A., Jan 1 2016, In : Faraday Discussions. 193, p. 81-97 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Microarray analysis gene expression profiles in laryngeal muscle after recurrent laryngeal nerve injury

Bijangi-Vishehsaraei, K., Blum, K., Zhang, H., Safa, A. R. & Halum, S. L., Mar 2016, In : Annals of Otology, Rhinology and Laryngology. 125, 3, p. 247-256 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Models of inflammation: Carrageenan air pouch

Duarte, D. B., Vasko, M. R. & Fehrenbacher, J. C., Mar 1 2016, In : Current Protocols in Pharmacology. 2016, p. 5.6.1-5.6.9

Research output: Contribution to journalArticle

7 Scopus citations

Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons

Pittman, S. K., Gracias, N. G. & Fehrenbacher, J. C., May 1 2016, In : Experimental Neurology. 279, p. 104-115 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Oxidative metabolism and Ca2+ handling in isolated brain mitochondria and striatal neurons from R6/2 mice, a model of Huntington's disease

Hamilton, J., Pellman, J. J., Brustovetsky, T., Harris, R. A. & Brustovetsky, N., Jan 1 2016, In : Human molecular genetics. 25, 13, p. 2762-2775 14 p.

Research output: Contribution to journalArticle

15 Scopus citations
18 Scopus citations

Peripheral ammonia and blood brain barrier structure and function after methamphetamine

Northrop, N. A., Halpin, L. E. & Yamamoto, B., Aug 1 2016, In : Neuropharmacology. 107, p. 18-26 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Phosphorylation of Eukaryotic Initiation Factor-2α during Stress and Encystation in Entamoeba Species

Hendrick, H. M., Welter, B. H., Hapstack, M. A., Sykes, S. E., Sullivan, W. & Temesvari, L. A., Dec 8 2016, In : PLoS Pathogens. 12, 12, e1006085.

Research output: Contribution to journalArticle

10 Scopus citations

Resistance to cell death and its modulation in cancer stem cells

Safa, A. R., 2016, In : Critical Reviews in Oncogenesis. 21, 3-4, p. 203-219 17 p.

Research output: Contribution to journalArticle

42 Scopus citations

RNA-Seq Reveals Acute Manganese Exposure Increases Endoplasmic Reticulum Related and Lipocalin mRNAs in Caenorhabditis elegans

Rudgalvyte, M., Peltonen, J., Lakso, M., Nass, R. & Wong, G., Feb 1 2016, In : Journal of Biochemical and Molecular Toxicology. 30, 2, p. 97-105 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons

Georgiadis, M. M., Chen, Q., Meng, J., Guo, C., Wireman, R., Reed, A., Vasko, M. R. & Kelley, M. R., May 1 2016, In : DNA Repair. 41, p. 32-41 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H. E., Zhang, Z. Y., Liu, J. Y. & Zhang, J. T., Feb 11 2016, In : Oncogene. 35, 6, p. 783-792 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Specific targeting of the basolateral amygdala to projectionally defined pyramidal neurons in prelimbic and infralimbic cortex

Cheriyan, J., Kaushik, M. K., Ferreira, A. N. & Sheets, P. L., Jan 1 2016, In : eNeuro. 3, 2, p. 489-494 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration

Ohlemacher, S. K., Sridhar, A., Xiao, Y., Hochstetler, A. E., Sarfarazi, M., Cummins, T. R. & Meyer, J. S., Jun 1 2016, In : STEM CELLS. 34, 6, p. 1553-1562 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

t-boc synthesis of huwentoxin-i through native chemical ligation incorporating a trifluoromethanesulfonic acid cleavage strategy

Thapa, P., Cabalteja, C. C., Philips, E. E., Espiritu, M. J., Peigneur, S., Mille, B. G., Tytgat, J., Cummins, T. R. & Bingham, J. P., Sep 1 2016, In : Biopolymers. p. 737-745 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

TgATAT-mediated α-tubulin acetylation is required for division of the protozoan parasite Toxoplasma gondii

Varberg, J. M., Padgett, L. R., Arrizabalaga, G. & Sullivan, W. J., Jan 1 2016, In : mSphere. 1, 1, e00088-15.

Research output: Contribution to journalArticle

6 Scopus citations

The role of prostate inflammation and fibrosis in lower urinary tract symptoms

Bushman, W. A. & Jerde, T. J., Jan 1 2016, In : American Journal of Physiology - Renal Physiology. 311, 4, p. F817-F821

Research output: Contribution to journalArticle

16 Scopus citations

Trails of discovery: Unbreak my heart: A short history of the defibrillator and CPR

Sullivan, W., 2016, In : Dialogues in Cardiovascular Medicine. 21, 3, p. 217-221 5 p.

Research output: Contribution to journalArticle

Unusual Voltage-Gated Sodium Currents as Targets for Pain

Barbosa, C. & Cummins, T., 2016, (Accepted/In press) In : Current Topics in Membranes.

Research output: Contribution to journalArticle

4 Scopus citations

Upregulation of the sodium channel Na v β4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation

Xie, W., Tan, Z. Y., Barbosa, C., Strong, J. A., Cummins, T. R. & Zhang, J. M., Apr 1 2016, In : Pain. 157, 4, p. 879-891 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

ZLM-7 exhibits anti-angiogenic effects via impaired endothelial cell function and blockade of VEGF/VEGFR-2 signaling

Su, M., Huang, J., Li, J., Qin, X., Tang, X., Jin, F., Chen, S., Jiang, C., Zou, Z., Peng, K., Nuruzzaman, M., Zhang, J., Luo, J., Liu, S. & Luo, Z., Jan 1 2016, In : Oncotarget. 7, 14, p. 19018-19030 13 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities

Chen, Y. W., Harris, R. A., Hatahet, Z. & Chou, K. M., Aug 18 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 33, p. E4556-E4564

Research output: Contribution to journalArticle

15 Scopus citations

Ca2+ handling in isolated brain mitochondria and cultured neurons derived from the YAC128 mouse model of Huntington's disease

Pellman, J. J., Hamilton, J., Brustovetsky, T. & Brustovetsky, N., Aug 1 2015, In : Journal of Neurochemistry. 134, 4, p. 652-667 16 p., 13165.

Research output: Contribution to journalArticle

17 Scopus citations

Characterization of autoimmune inflammation induced prostate stem cell expansion

Wang, H. H., Wang, L., Jerde, T. J., Chan, B. D., Savran, C. A., Burcham, G. N., Crist, S. & Ratliff, T. L., Oct 1 2015, In : Prostate. 75, 14, p. 1620-1631 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Chemotherapy-induced peripheral neuropathy

Fehrenbacher, J., 2015, In : Progress in Molecular Biology and Translational Science. 131, p. 471-508 38 p.

Research output: Contribution to journalArticle

33 Scopus citations
7 Scopus citations

Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer

Prabhu, L., Mundade, R., Wang, B., Wei, H., Hartley, A. V., Martin, M., McElyea, K., Temm, C. J., Sandusky, G., Liu, Y. & Lu, T., Jan 1 2015, In : Oncotarget. 6, 30, p. 29396-29412 17 p.

Research output: Contribution to journalArticle

17 Scopus citations

Dichloroacetate alters Warburg metabolism, inhibits cell growth, and increases the X-ray sensitivity of human A549 and H1299 NSC lung cancer cells

Tan Allen, K., Chin-Sinex, H., DeLuca, T., Pomerening, J. R., Sherer, J., Watkins, J. B., Foley, J., Jesseph, J. M. & Mendonca, M. S., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 263-273 11 p., 12539.

Research output: Contribution to journalArticle

16 Scopus citations

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock

Mantel, C. R., O'Leary, H. A., Chitteti, B. R., Huang, X., Cooper, S., Hangoc, G., Brustovetsky, N., Srour, E. F., Lee, M. R., Messina-Graham, S., Haas, D. M., Falah, N., Kapur, R., Pelus, L. M., Bardeesy, N., Fitamant, J., Ivan, M., Kim, K. S. & Broxmeyer, H. E., Jun 18 2015, In : Cell. 161, 7, p. 1553-1565 13 p.

Research output: Contribution to journalArticle

123 Scopus citations

Expansion of prostate epithelial progenitor cells after inflammation of the mouse prostate

Wang, L., Zoetemelk, M., Chitteti, B. R., Ratliff, T. L., Myers, J. D., Srour, E. F., Broxmeyer, H. & Jerde, T. J., Jun 15 2015, In : American Journal of Physiology - Renal Physiology. 308, 12, p. F1421-F1430

Research output: Contribution to journalArticle

8 Scopus citations

Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis

Benmerzouga, I., Checkley, L. A., Ferdig, M. T., Arrizabalaga, G., Wek, R. C. & Sullivan, W. J., Nov 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6939-6945 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala

Ferreira, A. N., Yousuf, H., Dalton, S. & Sheets, P. L., Apr 28 2015, In : Frontiers in Cellular Neuroscience. 9, APR, 161.

Research output: Contribution to journalArticle

16 Scopus citations
11 Scopus citations

Men with acute cholecystitis have higher tissue-based cytokine levels than women: A cross-sectional study

Fehrenbacher, J., Bingener, J., Aho, J. M., Wasky, P. R., Locke, E. E., Schwesinger, W. H., Van Sickle, K. R. & Hargreaves, K. M., Apr 1 2015, In : Chirurgia (Turin). 28, 2, p. 49-53 5 p.

Research output: Contribution to journalArticle

Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons

Barbosa, C., Tan, Z. Y., Wang, R., Xie, W., Strong, J. A., Patel, R. R., Vasko, M. R., Zhang, J. M. & Cummins, T. R., Sep 25 2015, In : Molecular Pain. 11, 1, 60.

Research output: Contribution to journalArticle

21 Scopus citations

NF-κB: Regulation by methylation

Lu, T. & Stark, G. R., Sep 15 2015, In : Cancer Research. 75, 18, p. 3692-3695 4 p.

Research output: Contribution to journalArticle

40 Scopus citations

Oxidative metabolism in YAC128 mouse model of Huntington's disease

Hamilton, J., Pellman, J. J., Brustovetsky, T., Harris, R. A. & Brustovetsky, N., Jan 1 2015, In : Human molecular genetics. 24, 17, p. 4862-4878 17 p.

Research output: Contribution to journalArticle

23 Scopus citations

Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egress

Gaji, R. Y., Johnson, D. E., Treeck, M., Wang, M., Hudmon, A. & Arrizabalaga, G., Nov 1 2015, In : PLoS Pathogens. 11, 11, e1005268.

Research output: Contribution to journalArticle

30 Scopus citations

Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model

Tonsing-Carter, E., Bailey, B. J., Saadatzadeh, M. R., Ding, J., Wang, H., Sinn, A. L., Peterman, K. M., Spragins, T. K., Silver, J. M., Sprouse, A. A., Georgiadis, T. M., Gunter, T. Z., Long, E. C., Minto, R. E., Marchal, C. C., Batuello, C. N., Safa, A. R., Hanenberg, H., Territo, P. R., Sandusky, G. E. & 4 others, Mayo, L. D., Eischen, C. M., Shannon, H. E. & Pollok, K. E., Dec 1 2015, In : Molecular cancer therapeutics. 14, 12, p. 2850-2863 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Preventing friendly fire in the war on microbes

Sullivan, W. & Gilk, S. D., Oct 28 2015, In : Science Translational Medicine. 7, 311, aad4922.

Research output: Contribution to journalArticle

Proteome-wide lysine acetylation in cortical astrocytes and alterations that occur during infection with brain parasite Toxoplasma gondii

Bouchut, A., Chawla, A. R., Jeffers, V., Hudmon, A. & Sullivan, W. J., Mar 18 2015, In : PloS one. 10, 3, e0117966.

Research output: Contribution to journalArticle

12 Scopus citations

Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase

Fako, V. E., Wu, X., Pflug, B., Liu, J. Y. & Zhang, J. T., Jan 22 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 778-784 7 p.

Research output: Contribution to journalArticle

24 Scopus citations