Pharmacology & Toxicology

Publications 1971 2020

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2016
2 Citations (Scopus)

Microarray analysis gene expression profiles in laryngeal muscle after recurrent laryngeal nerve injury

Bijangi-Vishehsaraei, K., Blum, K., Zhang, H., Safa, A. & Halum, S. L., Mar 1 2016, In : Annals of Otology, Rhinology and Laryngology. 125, 3, p. 247-256 10 p.

Research output: Contribution to journalArticle

Recurrent Laryngeal Nerve Injuries
Laryngeal Muscles
Microarray Analysis
Transcriptome
Wallerian Degeneration
7 Citations (Scopus)

Models of Inflammation: Carrageenan Air Pouch

Duarte, D. B., Vasko, M. & Fehrenbacher, J., Mar 18 2016, In : Current Protocols in Pharmacology. 72

Research output: Contribution to journalArticle

Carrageenan
Air
Inflammation
Irritants
Exudates and Transudates
2 Citations (Scopus)

Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons

Pittman, S. K., Gracias, N. G. & Fehrenbacher, J., May 1 2016, In : Experimental Neurology. 279, p. 104-115 12 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Sensory Receptor Cells
Neurites
Microtubules
Paclitaxel
15 Citations (Scopus)

Oxidative metabolism and Ca2+ handling in isolated brain mitochondria and striatal neurons from R6/2 mice, a model of Huntington's disease

Hamilton, J., Pellman, J. J., Brustovetsky, T., Harris, R. & Broustovetski, N., 2016, In : Human Molecular Genetics. 25, 13, p. 2762-2775 14 p.

Research output: Contribution to journalArticle

Corpus Striatum
Huntington Disease
Mitochondria
Neurons
Brain
6 Citations (Scopus)

Oxidative metabolism and Ca2+ handling in striatal mitochondria from YAC128 mice, a model of Huntington's disease

Hamilton, J., Brustovetsky, T. & Broustovetski, N., Nov 21 2016, (Accepted/In press) In : Neurochemistry International.

Research output: Contribution to journalArticle

Corpus Striatum
Huntington Disease
Mitochondria
Respiration
Pathology
14 Citations (Scopus)
Monensin
Toxoplasma
Oxidative Stress
Parasites
Antioxidants
11 Citations (Scopus)

Peripheral ammonia and blood brain barrier structure and function after methamphetamine

Northrop, N. A., Halpin, L. E. & Yamamoto, B., Aug 1 2016, In : Neuropharmacology. 107, p. 18-26 9 p.

Research output: Contribution to journalArticle

Methamphetamine
Blood-Brain Barrier
Ammonia
Matrix Metalloproteinases
Claudin-5
9 Citations (Scopus)

Phosphorylation of Eukaryotic Initiation Factor-2α during Stress and Encystation in Entamoeba Species

Hendrick, H. M., Welter, B. H., Hapstack, M. A., Sykes, S. E., Sullivan, W. & Temesvari, L. A., Dec 8 2016, In : PLoS Pathogens. 12, 12, e1006085.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Entamoeba
Entamoeba histolytica
Phosphorylation
Eukaryotic Initiation Factors
39 Citations (Scopus)

Resistance to cell death and its modulation in cancer stem cells

Safa, A., 2016, In : Critical Reviews in Oncogenesis. 21, 3-4, p. 203-219 17 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Cell Death
Neoplasms
Therapeutics
Radiotherapy
8 Citations (Scopus)

RNA-Seq Reveals Acute Manganese Exposure Increases Endoplasmic Reticulum Related and Lipocalin mRNAs in Caenorhabditis elegans

Rudgalvyte, M., Peltonen, J., Lakso, M., Nass, R. & Wong, G., Feb 1 2016, In : Journal of Biochemical and Molecular Toxicology. 30, 2, p. 97-105 9 p.

Research output: Contribution to journalArticle

Lipocalins
Caenorhabditis elegans
Manganese
Endoplasmic Reticulum
RNA
4 Citations (Scopus)

Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons

Georgiadis, M., Chen, Q., Meng, J., Guo, C., Wireman, R., Reed, A., Vasko, M. & Kelley, M., May 1 2016, In : DNA Repair. 41, p. 32-41 10 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Endonucleases
Sensory Receptor Cells
Nicorandil
Cisplatin
30 Citations (Scopus)

Specific Targeting of the Basolateral Amygdala to Projectionally Defined Pyramidal Neurons in Prelimbic and Infralimbic Cortex

Cheriyan, J., Kaushik, M. K., Ferreira, A. N. & Sheets, P., Mar 1 2016, In : eNeuro. 3, 2

Research output: Contribution to journalArticle

Pyramidal Cells
Neurons
Periaqueductal Gray
Fear
Optogenetics
39 Citations (Scopus)

Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration

Ohlemacher, S. K., Sridhar, A., Xiao, Y., Hochstetler, A. E., Sarfarazi, M., Cummins, T. & Meyer, J. S., 2016, (Accepted/In press) In : Stem Cells.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Retinal Ganglion Cells
Induced Pluripotent Stem Cells
Glaucoma
Forensic Anthropology
3 Citations (Scopus)

t-boc synthesis of huwentoxin-i through native chemical ligation incorporating a trifluoromethanesulfonic acid cleavage strategy

Thapa, P., Cabalteja, C. C., Philips, E. E., Espiritu, M. J., Peigneur, S., Mille, B. G., Tytgat, J., Cummins, T. & Bingham, J. P., Sep 1 2016, In : Biopolymers. p. 737-745 9 p.

Research output: Contribution to journalArticle

Ligation
Hydrofluoric Acid
Acids
Hydrogen
Peptides
6 Citations (Scopus)

TgATAT-mediated α-tubulin acetylation is required for division of the protozoan parasite Toxoplasma gondii

Varberg, J. M., Padgett, L. R., Arrizabalaga, G. & Sullivan, W., Jan 1 2016, In : mSphere. 1, 1, e00088-15.

Research output: Contribution to journalArticle

Toxoplasma
Tubulin
Acetylation
Parasites
Microtubules
11 Citations (Scopus)

The role of prostate inflammation and fibrosis in lower urinary tract symptoms

Bushman, W. A. & Jerde, T., 2016, In : American Journal of Physiology - Renal Physiology. 311, 4, p. F817-F821

Research output: Contribution to journalArticle

Lower Urinary Tract Symptoms
Prostate
Fibrosis
Inflammation
Urinary Bladder Neck Obstruction

Trails of discovery: Unbreak my heart: A short history of the defibrillator and CPR

Sullivan, W., 2016, In : Dialogues in Cardiovascular Medicine. 21, 3, p. 217-221 5 p.

Research output: Contribution to journalArticle

Defibrillators
Cardiopulmonary Resuscitation
Muscles
Electricity
Anura
4 Citations (Scopus)

Unusual Voltage-Gated Sodium Currents as Targets for Pain

Barbosa, C. & Cummins, T., 2016, (Accepted/In press) In : Current Topics in Membranes.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Sodium
Pain
Nociceptors
Sodium Channels
16 Citations (Scopus)

Upregulation of the sodium channel Na v β4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation

Xie, W., Tan, Z. Y., Barbosa, C., Strong, J. A., Cummins, T. & Zhang, J. M., Apr 1 2016, In : Pain. 157, 4, p. 879-891 13 p.

Research output: Contribution to journalArticle

Sodium Channels
Spinal Ganglia
Hypersensitivity
Up-Regulation
Small Interfering RNA
2015
13 Citations (Scopus)

Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities

Chen, Y. W., Harris, R., Hatahet, Z. & Chou, K. M., Aug 18 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 33, p. E4556-E4564

Research output: Contribution to journalArticle

DNA Damage
Adipose Tissue
Adipocytes
Genes
Obesity

Assessing knowledge and perceptions related to preventive methods and treatment of malaria in the local endemic area of Trujillo, Honduras

Campodonico, J., Sevilla-Martir, J., Arrizabalaga, G. & Kochhar, K., 2015, In : Hispanic Health Care International. 13, 2, p. 97-109 13 p.

Research output: Contribution to journalArticle

Honduras
Malaria
Insecticides
Central America
Cross-Sectional Studies
17 Citations (Scopus)

Ca<sup>2+</sup> handling in isolated brain mitochondria and cultured neurons derived from the YAC128 mouse model of Huntington's disease

Pellman, J. J., Hamilton, J., Brustovetsky, T. & Broustovetski, N., Aug 1 2015, In : Journal of Neurochemistry. 134, 4, p. 652-667 16 p., 13165.

Research output: Contribution to journalArticle

Mitochondria
Huntington Disease
Neurons
Brain
Mutant Proteins
6 Citations (Scopus)

Characterization of autoimmune inflammation induced prostate stem cell expansion

Wang, H. H., Wang, L., Jerde, T., Chan, B. D., Savran, C. A., Burcham, G. N., Crist, S. & Ratliff, T. L., Oct 1 2015, In : Prostate. 75, 14, p. 1620-1631 12 p.

Research output: Contribution to journalArticle

Prostate
Stem Cells
Inflammation
Prostatic Neoplasms
Ovalbumin
30 Citations (Scopus)

Chemotherapy-induced peripheral neuropathy

Fehrenbacher, J., 2015, In : Progress in Molecular Biology and Translational Science. 131, p. 471-508 38 p.

Research output: Contribution to journalArticle

Peripheral Nervous System Diseases
Drug Therapy
Pharmacology
Touch
Sensory Receptor Cells
7 Citations (Scopus)
Voltage-Gated Sodium Channels
Sodium Channels
Anticonvulsants
Protein Isoforms
Seizures
12 Citations (Scopus)

Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer

Prabhu, L., Mundade, R., Wang, B., Wei, H., Hartley, A. V., Martin, M., McElyea, K., Temm, C. J., Sandusky, G., Liu, Y. & Lu, T., 2015, In : Oncotarget. 6, 30, p. 29396-29412 17 p.

Research output: Contribution to journalArticle

Y-Box-Binding Protein 1
Colonic Neoplasms
Serine
Phosphorylation
Neoplasms
15 Citations (Scopus)

Dichloroacetate alters Warburg metabolism, inhibits cell growth, and increases the X-ray sensitivity of human A549 and H1299 NSC lung cancer cells

Tan Allen, K., Chin-Sinex, H., DeLuca, T., Pomerening, J. R., Sherer, J., Watkins, J. B., Foley, J., Jesseph, J. M. & Mendonca, M., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 263-273 11 p., 12539.

Research output: Contribution to journalArticle

Cell growth
Metabolism
Lung Neoplasms
Cells
X-Rays
109 Citations (Scopus)

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock

Mantel, C. R., O'Leary, H. A., Chitteti, B. R., Huang, X., Cooper, S., Hangoc, G., Broustovetski, N., Srour, E., Lee, M. R., Messina-Graham, S., Haas, D., Falah, N., Kapur, R., Pelus, L., Bardeesy, N., Fitamant, J., Ivan, M., Kim, K. S. & Broxmeyer, H., Jun 18 2015, In : Cell. 161, 7, p. 1553-1565 13 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Stem cells
Shock
Oxygen
5 Citations (Scopus)

Expansion of prostate epithelial progenitor cells after inflammation of the mouse prostate

Wang, L., Zoetemelk, M., Chitteti, B. R., Ratliff, T. L., Myers, J. D., Srour, E., Broxmeyer, H. & Jerde, T., Jun 15 2015, In : American Journal of Physiology - Renal Physiology. 308, 12, p. F1421-F1430

Research output: Contribution to journalArticle

Prostate
Stem Cells
Epithelial Cells
Inflammation
Hyperplasia
16 Citations (Scopus)

Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis

Benmerzouga, I., Checkley, L. A., Ferdig, M. T., Arrizabalaga, G., Wek, R. & Sullivan, W., Nov 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6939-6945 7 p.

Research output: Contribution to journalArticle

Guanabenz
Antiparasitic Agents
Toxoplasmosis
Toxoplasma
Cysts
14 Citations (Scopus)

Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala

Ferreira, A. N., Yousuf, H., Dalton, S. & Sheets, P., Apr 28 2015, In : Frontiers in Cellular Neuroscience. 9, APR, 161.

Research output: Contribution to journalArticle

Periaqueductal Gray
Pyramidal Cells
Amygdala
Neurons
Fear
10 Citations (Scopus)

Human Nav1.6 channels generate larger resurgent currents than human Nav1.1 channels, but the Navβ4 peptide does not protect either isoform from use-dependent reduction

Patel, R. R., Barbosa, C., Xiao, Y. & Cummins, T., Jul 16 2015, In : PLoS One. 10, 7, e0133485.

Research output: Contribution to journalArticle

action potentials
inactivation
Protein Isoforms
GABAergic Neurons
Action Potentials

Men with acute cholecystitis have higher tissue-based cytokine levels than women: A cross-sectional study

Fehrenbacher, J., Bingener, J., Aho, J. M., Wasky, P. R., Locke, E. E., Schwesinger, W. H., Van Sickle, K. R. & Hargreaves, K. M., Apr 1 2015, In : Chirurgia (Turin). 28, 2, p. 49-53 5 p.

Research output: Contribution to journalArticle

Acute Cholecystitis
Cross-Sectional Studies
Gallbladder
Cytokines
Extracellular Fluid
19 Citations (Scopus)

Mutant Huntingtin and Elusive Defects in Oxidative Metabolism and Mitochondrial Calcium Handling

Broustovetski, N., May 5 2015, (Accepted/In press) In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Huntington Disease
Calcium
Mitochondrial Dynamics
Mutation
Autophagy
17 Citations (Scopus)

Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons

Barbosa, C., Tan, Z. Y., Wang, R., Xie, W., Strong, J. A., Patel, R. R., Vasko, M., Zhang, J. M. & Cummins, T., Sep 25 2015, In : Molecular Pain. 11, 1, 60.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Spinal Ganglia
Sodium
Neurons
Voltage-Gated Sodium Channels
38 Citations (Scopus)

NF-κB: Regulation by methylation

Lu, T. & Stark, G. R., Sep 15 2015, In : Cancer Research. 75, 18, p. 3692-3695 4 p.

Research output: Contribution to journalArticle

Methylation
Lysine
Arginine
Neoplasms
Mutation
22 Citations (Scopus)

Oxidative metabolism in YAC128 mouse model of Huntington's disease

Hamilton, J., Pellman, J. J., Brustovetsky, T., Harris, R. & Broustovetski, N., 2015, In : Human Molecular Genetics. 24, 17, p. 4862-4878 17 p.

Research output: Contribution to journalArticle

Huntington Disease
Corpus Striatum
Neurons
Mitochondria
Respiration
28 Citations (Scopus)

Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egress

Gaji, R. Y., Johnson, D. E., Treeck, M., Wang, M., Hudmon, A. & Arrizabalaga, G., Nov 1 2015, In : PLoS Pathogens. 11, 11, e1005268.

Research output: Contribution to journalArticle

Toxoplasma
Myosins
Parasites
Phosphorylation
Serine
12 Citations (Scopus)

Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model

Tonsing-Carter, E., Bailey, B. J., Saadatzadeh, M. R., Ding, J., Wang, H., Sinn, A. L., Peterman, K. M., Spragins, T. K., Silver, J. M., Sprouse, A. A., Georgiadis, T. M., Gunter, T. Z., Long, E. C., Minto, R. E., Marchal, C. C., Batuello, C. N., Safa, A., Hanenberg, H., Territo, P., Sandusky, G. & 4 others, Mayo, L., Eischen, C. M., Shannon, H. E. & Pollok, K., Dec 1 2015, In : Molecular Cancer Therapeutics. 14, 12, p. 2850-2863 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Carboplatin
DNA Damage
Breast
Lung

Preventing friendly fire in the war on microbes

Sullivan, W. & Gilk, S. D., Oct 28 2015, In : Science Translational Medicine. 7, 311, aad4922.

Research output: Contribution to journalArticle

Pseudomonas Infections
Lung Injury
Pseudomonas aeruginosa
Lung
Warfare
12 Citations (Scopus)

Proteome-wide lysine acetylation in cortical astrocytes and alterations that occur during infection with brain parasite Toxoplasma gondii

Bouchut, A., Chawla, A. R., Jeffers, V., Hudmon, A. & Sullivan, W., Mar 18 2015, In : PLoS One. 10, 3, e0117966.

Research output: Contribution to journalArticle

Acetylation
astrocytes
Toxoplasma
acetylation
Proteome
19 Citations (Scopus)

Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase

Fako, V. E., Wu, X., Pflug, B., Liu, J. Y. & Zhang, J-T., Jan 22 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 778-784 7 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Proton Pump Inhibitors
Drug Delivery Systems
Neoplasms
Pharmaceutical Databases
8 Citations (Scopus)

Role of novel serine 316 phosphorylation of the p65 subunit of NF-κB in differential gene regulation

Wang, B., Wei, H., Prabhu, L., Zhao, W., Martin, M., Hartley, A. V. & Lu, T., Aug 14 2015, In : Journal of Biological Chemistry. 290, 33, p. 20336-20347 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Gene expression
Serine
Genes
Alanine
15 Citations (Scopus)

Sensitization of the trigeminovascular system following environmental irritant exposure

Kunkler, P. E., Zhang, L., Pellman, J. J., Oxford, G. S. & Hurley, J., Nov 1 2015, In : Cephalalgia. 35, 13, p. 1192-1201 10 p.

Research output: Contribution to journalArticle

Acrolein
Irritants
Environmental Exposure
Headache
Inhalation Exposure
41 Citations (Scopus)

Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H., Zhang, Z-Y., Liu, J. Y. & Zhang, J-T., Jun 15 2015, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Neoplasm Metastasis
Gene Expression
DNA
Growth
18 Citations (Scopus)

Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3

Li, C., Li, J. N., Kays, J., Guerrero, M. & Nicol, G., Apr 12 2015, In : Journal of Neuroinflammation. 12, 1, 70.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Sensory Receptor Cells
Small Interfering RNA
sphingosine 1-phosphate
Organophosphonates
17 Citations (Scopus)

Systemic and cerebral iron homeostasis in ferritin knock-out Mice

Li, W., Garringer, H., Goodwin, C. B., Richine, B., Acton, A., VanDuyn, N., Muhoberac, B. B., Irimia-Dominguez, J., Chan, R., Peacock, M., Nass, R., Ghetti, B. & Vidal, R., Jan 28 2015, In : PLoS One. 10, 1, e0117435.

Research output: Contribution to journalArticle

ferritin
Ferritins
Knockout Mice
homeostasis
Homeostasis
26 Citations (Scopus)

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

Herman, J. D., Pepper, L. R., Cortese, J. F., Estiu, G., Galinsky, K., Zuzarte-Luis, V., Derbyshire, E. R., Ribacke, U., Lukens, A. K., Santos, S. A., Patel, V., Clish, C. B., Sullivan, W., Zhou, H., Bopp, S. E., Schimmel, P., Lindquist, S., Clardy, J., Mota, M. M., Keller, T. L. & 4 others, Whitman, M., Wiest, O., Wirth, D. F. & Mazitschek, R., May 20 2015, In : Science Translational Medicine. 7, 288

Research output: Contribution to journalArticle

Malaria
Antimalarials
Parasites
Drug Resistance
Yeasts
2014
55 Citations (Scopus)

A small molecule compound targeting STAT3 DNA-binding domain inhibits cancer cell proliferation, migration, and invasion

Huang, W., Dong, Z., Wang, F., Peng, H., Liu, J. Y. & Zhang, J-T., May 16 2014, In : ACS Chemical Biology. 9, 5, p. 1188-1196 9 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Cell proliferation
Cell Movement
Cell Proliferation
Molecules
2 Citations (Scopus)

Canonical histone H2Ba and H2A.X dimerize in an opposite genomic localization to H2A.Z/H2B.Z dimers in Toxoplasma gondii

Bogado, S. S., Dalmasso, M. C., Ganuza, A., Kim, K., Sullivan, W., Angel, S. O. & Vanagas, L., 2014, In : Molecular and Biochemical Parasitology. 197, 1-2, p. 36-42 7 p.

Research output: Contribution to journalArticle

Toxoplasma
Histones
Nucleosomes
Antibodies
Chromatin Immunoprecipitation