Pharmacology & Toxicology

Publications 1970 2020

Filter
Article
1982
29 Citations (Scopus)

An Analysis of GABA Receptor Changes in the Discrete Regions of Mouse Brain After Acute and Chronic Treatments with Morphine

Sivam, S. P., Nabeshima, T. & Ho, I. K., Oct 1982, In : Journal of Neurochemistry. 39, 4, p. 933-939 7 p.

Research output: Contribution to journalArticle

GABA Receptors
Morphine
Brain
Diencephalon
Cerebellum
2 Citations (Scopus)

A simple method for scanning electron microscope preparation of cells grown in multiwell culture plates

Safa, A. R. & Tseng, M. T., Jan 1 1982, In : Biotechnic and Histochemistry. 57, 2, p. 107-112 6 p.

Research output: Contribution to journalArticle

Electrons
Artifacts
Plastics
Electron Scanning Microscopy
Buffers
5 Citations (Scopus)

Azidoacridines as photoaffinity probes for ionic channels in excitable membranes

Oxford, G. S. & Hudson, R. A., Feb 26 1982, In : Biochemical and Biophysical Research Communications. 104, 4, p. 1579-1584 6 p.

Research output: Contribution to journalArticle

Ion Channels
Quinacrine
Sodium Channels
Membranes
Electric potential

Colony forming capacity of cells derived from 7,12-dimethylbenz(a)anthracene induced mammary tumors in rat

Tseng, M. T., Safa, A. R., Halbig, T. & Bertoloir, S., Jan 1 1982, In : Journal of Cell Biology. 95, 2 II, p. no.9073

Research output: Contribution to journalArticle

Breast Neoplasms
anthracene

Depletion of hepatic UDP-glucuronic acid (UDPGA) decreases the biliary excretion of drugs

Watkins, J. B., Gregus, Z., Thompson, T. B. & Klaassen, C. D., Jan 1 1982, In : Hepatology. 2, 5, p. No. 119

Research output: Contribution to journalArticle

Uridine Diphosphate Glucuronic Acid
Liver
Pharmaceutical Preparations
Hepatobiliary Elimination
33 Citations (Scopus)

Determination of hepatic uridine 5′-diphosphoglucuronic acid concentration by conjugation with diethylstilbestrol

Watkins, J. B. & Klaassen, C. D., Mar 1982, In : Journal of Pharmacological Methods. 7, 2, p. 145-151 7 p.

Research output: Contribution to journalArticle

Uridine Diphosphate Glucuronic Acid
Diethylstilbestrol
Uridine
Acids
Liver
23 Citations (Scopus)

Development of dispositional tolerance to phencyclidine by osmotic minipump in the mouse

Toshitaka, N., Sivam, S. P., Tai, C. Y. & Ho, I. K., May 1982, In : Journal of Pharmacological Methods. 7, 3, p. 239-253 15 p.

Research output: Contribution to journalArticle

Phencyclidine
Ataxia
Cytochromes b5
Inbred ICR Mouse
Phosphoric Monoester Hydrolases
45 Citations (Scopus)

Effect of inducers and inhibitors of glucuronidation on the biliary excretion and choleretic action of valproic acid in the rat

Watkins, J. B. & Klaassen, C. D., Jan 1 1982, In : Journal of Pharmacology and Experimental Therapeutics. 220, 2, p. 305-310 6 p.

Research output: Contribution to journalArticle

Cholagogues and Choleretics
Valproic Acid
Bile
Galactosamine
Glucuronic Acid
64 Citations (Scopus)

Effect of microsomal enzyme inducers on the soluble enzymes of hepatic phase II biotransformation

Thompson, T. N., Watkins, J. B., Gregus, Z. & Klaassen, C. D., Dec 1982, In : Toxicology and Applied Pharmacology. 66, 3, p. 400-408 9 p.

Research output: Contribution to journalArticle

Biotransformation
Pregnenolone Carbonitrile
Liver
Enzymes
Butylated Hydroxyanisole
44 Citations (Scopus)

Induction of UDP-glucuronosyltransferase activities in Gunn, heterozygous, and Wistar rat livers by pregnenolone-16α-carbonitrile

Watkins, J. B. & Klaassen, C. D., Dec 1 1982, In : Drug Metabolism and Disposition. 10, 6, p. 590-594 5 p.

Research output: Contribution to journalArticle

Gunn Rats
Pregnenolone Carbonitrile
Glucuronosyltransferase
Liver
Wistar Rats
95 Citations (Scopus)

Induction studies on the functional heterogeneity of rat liver UDP-glucuronosyltransferases

Watkins, J. B., Gregus, Z., Thompson, T. N. & Klaassen, C. D., Jul 1982, In : Toxicology and Applied Pharmacology. 64, 3, p. 439-446 8 p.

Research output: Contribution to journalArticle

Glucuronosyltransferase
Pregnenolone Carbonitrile
Phenobarbital
Liver
Rats

Influence of inhibitors of plant cell division and wall formation on mammary tumor cells in primary culture

Safa, A. R. & Tseng, M. T., Jan 1 1982, In : Federation Proceedings. 41, 4, p. No. 6090

Research output: Contribution to journalArticle

Primary Cell Culture
Plant Cells
Cell Division
Cell Wall
Breast Neoplasms
21 Citations (Scopus)

Influence of morphine dependence on GABA-stimulated benzodiazepine binding to mouse brain synaptic membranes

Sivam, S. P. & Ho, I. K., Apr 23 1982, In : European Journal of Pharmacology. 79, 3-4, p. 335-336 2 p.

Research output: Contribution to journalArticle

Morphine Dependence
Drug Receptors
Flunitrazepam
Synaptic Membranes
Inbred ICR Mouse
4 Citations (Scopus)

Interaction of ouabain and propranolol in the central nervous system. Neurally-mediated effects on the cardiovascular system

Sivam, S. P., Seth, S. D., Nayar, U. & Manchanda, S. C., Jan 1 1982, In : Pharmacology. 25, 5, p. 286-293 8 p.

Research output: Contribution to journalArticle

Ouabain
Cardiovascular System
Propranolol
Central Nervous System
Local Anesthetics
63 Citations (Scopus)

Normal rats trained to circle show asymmetric caudate dopamine release

Yamamoto, B. K., Lane, R. F. & Freed, C. R., Jun 21 1982, In : Life Sciences. 30, 25, p. 2155-2162 8 p.

Research output: Contribution to journalArticle

Rats
Dopamine
3,4-Dihydroxyphenylacetic Acid
Catecholamines
Electrochemical electrodes
5 Citations (Scopus)

Preparing autoradiographs of monolayer cell culture grown in polystyrene multiwell plates for scoring labeling indices

Safa, A. R. & Tseng, M. T., Jan 1 1982, In : Biotechnic and Histochemistry. 57, 5, p. 319-321 3 p.

Research output: Contribution to journalArticle

Polystyrenes
Cell Culture Techniques

Resistance of some biotransformation pathways to hepatotoxins

Watkins, J. B., Gregus, Z., Thompson, T. N. & Klaassen, C. D., Jan 1 1982, In : Federation Proceedings. 41, 5, 1 p.

Research output: Contribution to journalArticle

Biotransformation
42 Citations (Scopus)

Resistance of some phase II biotransformation pathways to hepatotoxins

Gregus, Z., Watkins, J. B., Thompson, T. N. & Klaassen, C. D., Jan 1 1982, In : Journal of Pharmacology and Experimental Therapeutics. 222, 2, p. 471-479 9 p.

Research output: Contribution to journalArticle

Biotransformation
Epoxide Hydrolases
Liver
Cytochrome P-450 Enzyme System
Ethylmorphine
1 Citation (Scopus)

Solubilization of hormone-responsive adenylate cyclase from human renal cortex

Hamel, F. G. & Queener, S. F., Sep 30 1982, In : Biochemical and Biophysical Research Communications. 108, 2, p. 567-575 9 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Calcitonin
Hormones
Glucagon
Kidney

The trained circling rat: A model for studying asymmetric caudate dopamine metabolism in normal animals

Yamamoto, B. K. & Freed, C. R., Jan 1 1982, In : Federation Proceedings. 41, 5, p. No. 7399

Research output: Contribution to journalArticle

Dopamine
63 Citations (Scopus)

The trained circling rat: A model for inducing unilateral caudate dopamine metabolism

Yamamoto, B. K. & Freed, C. R., Dec 1 1982, In : Nature. 298, 5873, p. 467-468 2 p.

Research output: Contribution to journalArticle

Dopamine
Brain
Acids
Dopamine Agents
Dopaminergic Neurons
Opioid Receptors
Morphine
1983
33 Citations (Scopus)

Changes in renal phospholipid fatty acids in diabetes mellitus: Correlation with changes in adenylate cyclase activity

Clark, D. L., Hamel, F. G. & Queener, S. F., Oct 1 1983, In : Lipids. 18, 10, p. 696-705 10 p.

Research output: Contribution to journalArticle

adenylate cyclase
Medical problems
diabetes mellitus
Adenylyl Cyclases
Cell membranes
56 Citations (Scopus)

Chemically-induced alteration of UDP-glucuronic acid concentration in rat liver

Watkins, J. B. & Klaassen, C. D., Jan 1 1983, In : Drug Metabolism and Disposition. 11, 1, p. 37-40 4 p.

Research output: Contribution to journalArticle

Uridine Diphosphate Glucuronic Acid
Liver
Rats
Pregnenolone Carbonitrile
Galactosamine
3 Citations (Scopus)

Choleretic effect of structural analogs of valproic acid in the rat

Watkins, J. B. & Klaassen, C. D., Jan 1 1983, In : Research Communications in Chemical Pathology and Pharmacology. 39, 3, p. 355-366 12 p.

Research output: Contribution to journalArticle

Cholagogues and Choleretics
Valproic Acid
Rats
Bile
2,2-dimethylbutyric acid
30 Citations (Scopus)

Depletion of hepatic uridine diphosphoglucuronic acid decreases the biliary excretion of drugs

Gregus, Z., Watkins, J. B., Thompson, T. N. & Klaassen, C. D., Jan 1 1983, In : Journal of Pharmacology and Experimental Therapeutics. 225, 2, p. 256-262 7 p.

Research output: Contribution to journalArticle

Uridine Diphosphate Glucuronic Acid
Galactosamine
Ether
Liver
Iopanoic Acid
17 Citations (Scopus)

Diisopropylfluorophosphate and GABA synaptic function: Effect on levels, enzymes, release and uptake in the rat striatum

Sivam, S. P., Nabeshima, T., Lim, D. K., Hoskins, B. & Ho, I. K., Dec 1 1983, In : Research Communications in Chemical Pathology and Pharmacology. 42, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

Isoflurophate
gamma-Aminobutyric Acid
Rats
Enzymes
4-Aminobutyrate Transaminase
12 Citations (Scopus)
Doxorubicin
Breast Neoplasms
Growth
Antimitotic Agents
Myelin Sheath
90 Citations (Scopus)

Effect of Acute and Chronic Cholinesterase Inhibition with Diisopropylfluorophosphate on Muscarinic, Dopamine, and GABA Receptors of the Rat Striatum

Sivam, S. P., Norris, J. C., Lim, D. K., Hoskins, B. & Ho, I. K., May 1983, In : Journal of Neurochemistry. 40, 5, p. 1414-1422 9 p.

Research output: Contribution to journalArticle

Isoflurophate
GABA Receptors
Cholinesterases
Dopamine Receptors
Muscarinic Receptors
6 Citations (Scopus)

Effect of gentamicin treatment on adenylate cyclase and Na+,K+-ATPase activities in renal tissues of rats

Queener, S. F., Luft, F. C. & Hamel, F. G., Jan 1 1983, In : Antimicrobial Agents and Chemotherapy. 24, 5, p. 815-818 4 p.

Research output: Contribution to journalArticle

Open Access
Gentamicins
Adenylyl Cyclases
Kidney
Cell Membrane
Isoproterenol
17 Citations (Scopus)
Phencyclidine
Morphine
Opiate Alkaloids
Liver
Aniline Hydroxylase
36 Citations (Scopus)

Gabaergic drugs, morphine and morphine tolerance: A study in relation to nociception and gastrointestinal transit in mice

Sivam, S. P. & Ho, I. K., Jun 1983, In : Neuropharmacology. 22, 6, p. 767-774 8 p.

Research output: Contribution to journalArticle

Gastrointestinal Transit
Nociception
Morphine
Pharmaceutical Preparations
Muscimol
95 Citations (Scopus)

Hepatic phase I and phase II biotransformations in quail and trout: Comparison to other species commonly used in toxicity testing

Gregus, Z., Watkins, J. B., Thompson, T. N., Harvey, M. J., Rozman, K. & Klaassen, C. D., Mar 15 1983, In : Toxicology and Applied Pharmacology. 67, 3, p. 430-441 12 p.

Research output: Contribution to journalArticle

Quail
Trout
Biotransformation
Toxicity
Liver

Improved visualization of cell nuclei in unstained cultured cells

Ballou, R. J., Safa, A. R. & Tseng, M. T., Jan 1 1983, In : Biotechnic and Histochemistry. 58, 4, p. 233-235 3 p.

Research output: Contribution to journalArticle

Cell Nucleus
Cultured Cells
Population Characteristics
15 Citations (Scopus)

Influence of mitoxantrone on nucleic acid synthesis on the T‐47D breast tumor cell line

Safa, A. R., Chegini, N. & Tseng, M. T., 1983, In : Journal of Cellular Biochemistry. 22, 2, p. 111-120 10 p.

Research output: Contribution to journalArticle

Mitoxantrone
Tumor Cell Line
Nucleic Acids
Drug therapy
Tumors
20 Citations (Scopus)

Interaction of internal anions with potassium channels of the squid giant axon

Adams, D. J. & Oxford, G. S., Oct 1 1983, In : Journal of General Physiology. 82, 4, p. 429-448 20 p.

Research output: Contribution to journalArticle

Open Access
Decapodiformes
Potassium Channels
Anions
Axons
Fluorides
3 Citations (Scopus)

In vitro drug screening and individualized treatment planning for cancer patients.

Tseng, M. T. & Safa, A. R., Jan 1 1983, In : Cancer detection and prevention. 6, 3, p. 371-379 9 p.

Research output: Contribution to journalArticle

Preclinical Drug Evaluations
Doxorubicin
Thiotepa
Neoplasms
9,10-Dimethyl-1,2-benzanthracene

Isolation and preparation of colonies grown on soft agar for ultrastructural investigation

Safa, A. R. & Tseng, M. T., Apr 1983, In : Journal of Microscopy. 130, 1, p. 119-122 4 p.

Research output: Contribution to journalArticle

Agar
Electrons
2 Citations (Scopus)

Lactate dehydrogenase activity in cell subpopulations of 7,12-dimethylbenz(a)anthracene-induced mammary tumors

Safa, A. R. & Tseng, M. T., Mar 1983, In : Experientia. 39, 3, p. 283-285 3 p.

Research output: Contribution to journalArticle

L-Lactate Dehydrogenase
Tumors
Breast Neoplasms
Enzyme activity
Ovariectomy
6 Citations (Scopus)
bisantrene
Cultured Tumor Cells
Electrons
Breast Neoplasms
Light

Mechanism of tolerance development to pentobarbital in relation to GABA-ergic neuronal and dispositional functions in mice

Nabeshima, T., Kameyama, T., Sivam, S. & Ho, I. K., Jan 1 1983, In : Journal of Pharmacobio-Dynamics. 6, 3, p. s-61

Research output: Contribution to journalArticle

43 Citations (Scopus)

Minimal role of metallothionein in decreased chelator efficacy for cadmium

Waalkes, M. P., Watkins, J. B. & Klaassen, C. D., May 1983, In : Toxicology and Applied Pharmacology. 68, 3, p. 392-398 7 p.

Research output: Contribution to journalArticle

Metallothionein
Chelating Agents
Cadmium
Pentetic Acid
Poisoning
3 Citations (Scopus)

Response of 7,12-Dimethylbenz(a)anthracene-Induced Rat Mammary Tumor Cells to Tamoxifen, in Vitro

Ballou, R. J., Safa, A. R. & Tseng, M. T., Jun 1983, In : Proceedings of the Society for Experimental Biology and Medicine. 173, 2, p. 256-263 8 p.

Research output: Contribution to journalArticle

Tamoxifen
Rats
Tumors
9,10-Dimethyl-1,2-benzanthracene
Cells
1 Citation (Scopus)

Selective maintenance of cultured epithelial cells from DMBA-induced mammary tumours by bovine colostrum supplement

Tseng, M. T., Safa, A. R. & Ballou, R., Jan 1 1983, In : Cell and Tissue Kinetics. 16, 1, p. 85-92 8 p.

Research output: Contribution to journalArticle

9,10-Dimethyl-1,2-benzanthracene
Colostrum
Cultured Cells
Epithelial Cells
Maintenance
3 Citations (Scopus)
Cultured Tumor Cells
Cell proliferation
Doxorubicin
Tumors
Cells
1984
5 Citations (Scopus)

Acute effects of mitoxantrone on the template activity of isolated nuclei from the T-47D human breast tumor cell line

Chegini, N., Safa, A. R. & Tseng, M. T., Jan 1984, In : Cancer Letters. 21, 3, p. 329-336 8 p.

Research output: Contribution to journalArticle

Mitoxantrone
Tumor Cell Line
Breast Neoplasms
RNA
Amanitins

Acute toxicity of Soman, Sarin and Tabun: Neurochemical evaluations related to cholinergic, GABAergic and dopamine systems

Sivam, S. P., Lim, D. K., Hoskins, B. & Ho, I. K., Jan 1 1984, In : Federation Proceedings. 43, 3, p. no. 1635

Research output: Contribution to journalArticle

Sarin
Soman
Cholinergic Agents
Dopamine
tabun
9 Citations (Scopus)

Analgesic cross-tolerance between morphine and opioid peptides

Sivam, S. P. & Ho, I. K., Sep 1 1984, In : Psychopharmacology. 84, 1, p. 64-65 2 p.

Research output: Contribution to journalArticle

Opioid Peptides
Morphine
Analgesics
Endorphins
Leucine-2-Alanine Enkephalin
46 Citations (Scopus)
Sarin
Soman
Isoflurophate
Enzyme activity
Acetylcholinesterase
2 Citations (Scopus)
Opiate Alkaloids
delta Opioid Receptor
mu Opioid Receptor
Analgesia
Morphine