Pharmacology & Toxicology

Publications 1970 2020

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9 Citations (Scopus)

An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite toxoplasma gondii

Liu, J., He, Y., Benmerzouga, I., Sullivan, W., Morrissette, N. S., Murray, J. M. & Hu, K., Feb 1 2016, In : Molecular Biology of the Cell. 27, 3, p. 549-571 23 p.

Research output: Contribution to journalArticle

Toxoplasma
Microtubules
Parasites
Proteins
Polymers
5 Citations (Scopus)

An enzyme-linked immunosorbent assay for enumeration of Pneumocystis carinii in vitro and in vivo

Durkin, M. M., Bartlett, M. S., Queener, S. F., Shaw, M. M., Lee, C. H. & Smith, J. W., Jan 1 1992, In : Journal of clinical microbiology. 30, 12, p. 3258-3262 5 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Enzyme-Linked Immunosorbent Assay
Antibodies
Lung
In Vitro Techniques
98 Citations (Scopus)

A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis

Yamamoto, B. K. & Pehek, E. A., Jan 8 1990, In : Brain research. 506, 2, p. 236-242 7 p.

Research output: Contribution to journalArticle

Electrochemistry
Microdialysis
Dopamine
3,4-Dihydroxyphenylacetic Acid
Sulpiride
105 Citations (Scopus)

A new mechanism of drug resistance in breast cancer cells: Fatty acid synthase overexpression-mediated palmitate overproduction

Liu, H., Liu, Y. & Zhang, J. T., Feb 1 2008, In : Molecular cancer therapeutics. 7, 2, p. 263-270 8 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Palmitates
Drug Resistance
Breast Neoplasms
Cell Line
172 Citations (Scopus)

An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3′ mispaired DNA

Chou, K. M. & Cheng, Y. C., Feb 7 2002, In : Nature. 415, 6872, p. 655-659 5 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Human Activities
DNA Repair
DNA
Exodeoxyribonucleases

Animation of intestinal absorption, enterohepatic circulation and intestinal and renal elimination

Watkins, J. B., Dec 1 1997, In : FASEB Journal. 11, 3, p. A221

Research output: Contribution to journalArticle

Enterohepatic Circulation
intestinal absorption
Intestinal Absorption
Animation
students
298 Citations (Scopus)
Microdialysis
Neurotransmitter Agents
Brain
High Pressure Liquid Chromatography
Tissue
1 Citation (Scopus)

An Improved Rat Model to Study Efficacy of Drugs for Treatment or Prophylaxis of Pneumocystis carinii Pneumonia

BARLETT, MARILYN. S., FISHMAN, JAY. A., DURKIN, MICHELLE. M., QUEENER, SHERRY. F. & SMITH, JAMES. W., Jan 1989, In : The Journal of Protozoology. 36, 1, p. 77S-78S

Research output: Contribution to journalArticle

Inbred Strains Rats
Animal Disease Models
Sulfamethoxazole
Drug Evaluation
Trimethoprim
10 Citations (Scopus)

An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer

Kedage, V., Selvaraj, N., Nicholas, T. R., Budka, J. A., Plotnik, J. P., Jerde, T. & Hollenhorst, P., Oct 25 2016, In : Cell Reports. 17, 5, p. 1289-1301 13 p.

Research output: Contribution to journalArticle

RNA-Binding Protein EWS
Ewing's Sarcoma
Prostate
Prostatic Neoplasms
Tumors
102 Citations (Scopus)

A novel action of human apurinic/apyrimidinic endonuclease. Excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA

Chou, K. M., Kukhanova, M. & Cheng, Y. C., Oct 6 2000, In : Journal of Biological Chemistry. 275, 40, p. 31009-31015 7 p.

Research output: Contribution to journalArticle

Open Access
DNA-(Apurinic or Apyrimidinic Site) Lyase
Deoxyribonucleosides
Endonucleases
Nucleosides
Zalcitabine
16 Citations (Scopus)

A novel benzodioxole-containing inhibitor of Toxoplasma gondii growth alters the parasite cell cycle

Kamau, E., Meehan, T., Lavine, M. D., Arrizabalaga, G., Wilson, G. M. & Boyle, J., Dec 1 2011, In : Antimicrobial Agents and Chemotherapy. 55, 12, p. 5438-5451 14 p.

Research output: Contribution to journalArticle

Toxoplasma
Cell Cycle
Parasites
Growth
Antiparasitic Agents
29 Citations (Scopus)

A novel comonomer-free light-cured glass-ionomer cement for reduced cytotoxicity and enhanced mechanical strength

Xie, D., Yang, Y., Zhao, J., Park, J. G. & Zhang, J. T., Aug 1 2007, In : Dental Materials. 23, 8, p. 994-1003 10 p.

Research output: Contribution to journalArticle

Glass Ionomer Cements
Ionomers
Cytotoxicity
carbopol 940
Strength of materials
10 Citations (Scopus)

A novel dense granule protein, GRA41, regulates timing of egress and calcium sensitivity in Toxoplasma gondii

Lafavers, K. A., Márquez-Nogueras, K. M., Coppens, I., Moreno, S. N. J. & Arrizabalaga, G., 2017, (Accepted/In press) In : Cellular Microbiology.

Research output: Contribution to journalArticle

Toxoplasma
Calcium
Parasites
Vacuoles
Proteins

A novel GCN5b lysine acetyltransferase complex associates with distinct transcription factors in the protozoan parasite Toxoplasma gondii

Harris, M. T., Jeffers, V., Martynowicz, J., True, J. D., Mosley, A. & Sullivan, W., Sep 1 2019, In : Molecular and Biochemical Parasitology. 232, 111203.

Research output: Contribution to journalArticle

Toxoplasma
Parasites
Transcription Factors
Eukaryota
Epigenomics
318 Citations (Scopus)

A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons.

Cummins, T. R., Dib-Hajj, S. D., Black, J. A., Akopian, A. N., Wood, J. N. & Waxman, S. G., Dec 15 1999, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 19, 24, p. RC43

Research output: Contribution to journalArticle

Tetrodotoxin
Spinal Ganglia
Sensory Receptor Cells
Sodium Channels
Sodium
94 Citations (Scopus)

A novel role of DNA polymerase η in modulating cellular sensitivity to chemotherapeutic agents

Chen, Y. W., Cleaver, J. E., Hanaoka, F., Chang, C. F. & Chou, K. M., Apr 1 2006, In : Molecular Cancer Research. 4, 4, p. 257-265 9 p.

Research output: Contribution to journalArticle

gemcitabine
DNA-Directed DNA Polymerase
Cisplatin
Antineoplastic Agents
pol Genes
38 Citations (Scopus)

A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapy

Peng, H., Dong, Z., Qi, J., Yang, Y., Liu, Y., Li, Z., Xu, J. & Zhang, J. T., May 24 2009, In : PLoS ONE. 4, 5, e5676.

Research output: Contribution to journalArticle

Chemotherapy
multiple drug resistance
Multiple Drug Resistance
Stem cells
drug therapy
77 Citations (Scopus)

An rRNA mutation identifies the apicoplast as the target for clindamycin in Toxoplasma gondii

Camps, M., Arrizabalaga, G. & Boothroyd, J., Apr 23 2002, In : Molecular Microbiology. 43, 5, p. 1309-1318 10 p.

Research output: Contribution to journalArticle

Apicoplasts
Clindamycin
Toxoplasma
Mutation
Macrolides
22 Citations (Scopus)
Open Access
Cyclohexanecarboxylic Acids
Anthranilate Synthase
ortho-Aminobenzoates
Microbial Genetics
Genetic Complementation Test
17 Citations (Scopus)

Anthranilate synthase from Pseudomonas putida. Purification and properties of a two-component enzyme.

Queener, S. W., Queener, S. F., Meeks, J. R. & Gunsalus, I. C., Jan 10 1973, In : Journal of Biological Chemistry. 248, 1, p. 151-161 11 p.

Research output: Contribution to journalArticle

Anticholinesterase effect of sotalol

Alkondon, M., Sivam, S. P., Bhatia, S. & Sen, P., Jan 1 1981, In : Indian Journal of Medical Research. 73, 5, p. 796-800 5 p.

Research output: Contribution to journalArticle

Practolol
Ranidae
Sotalol
Abdominal Muscles
Physostigmine
30 Citations (Scopus)

Antimicrotubule benzimidazoles inhibit in vitro growth of Pneumocystis carinii

Bartlett, M. S., Edlind, T. D., Durkin, M. M., Shaw, M. M., Queener, S. F. & Smith, J. W., Jan 1 1992, In : Antimicrobial Agents and Chemotherapy. 36, 4, p. 779-782 4 p.

Research output: Contribution to journalArticle

Open Access
Benzimidazoles
Pneumocystis carinii
Thiabendazole
Structure-Activity Relationship
Growth
2 Citations (Scopus)
Opiate Alkaloids
delta Opioid Receptor
mu Opioid Receptor
Analgesia
Morphine

Antitumor activity and mechanistic characterization of APE1/ReF-1 inhibitors in bladder cancer

Fishel, M. L., Xia, H., McGeown, J., McIlwain, D. W., Elbanna, M., Craft, A. A., Kaimakliotis, H. Z., Sandusky, G. E., Zhang, C., Pili, R., Kelley, M. R. & Jerde, T. J., Jan 1 2019, In : Molecular cancer therapeutics. 18, 11, p. 1947-1960 14 p.

Research output: Contribution to journalArticle

Endonucleases
Urinary Bladder Neoplasms
Oxidation-Reduction
Cisplatin
Cell Proliferation
8 Citations (Scopus)

APC loss in breast cancer leads to doxorubicin resistance via STAT3 activation

VanKlompenberg, M. K., Leyden, E., Arnason, A. H., Zhang, J-T., Stefanski, C. D. & Prosperi, J., Jan 1 2017, In : Oncotarget. 8, 61, p. 102868-102879 12 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Adenomatous Polyposis Coli
Mouse mammary tumor virus
Doxorubicin
Transcriptional Activation
15 Citations (Scopus)

APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER

Kim, H. S., Guo, C., Thompson, E. L., Jiang, Y., Kelley, M. R., Vasko, M. R. & Lee, S. H., Sep 1 2015, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 779, p. 96-104 9 p.

Research output: Contribution to journalArticle

Platinum
DNA Repair
Cisplatin
DNA
Proteins
4 Citations (Scopus)

APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells

McIlwain, D. W., Fishel, M., Boos, A., Kelley, M. & Jerde, T., Jan 1 2018, In : Oncotarget. 9, 13, p. 10962-10977 16 p.

Research output: Contribution to journalArticle

Endonucleases
Cell Cycle Checkpoints
Oxidation-Reduction
Prostatic Neoplasms
Proteins
21 Citations (Scopus)
Caspase 6
Caspase 7
P-Glycoprotein
Doxorubicin
Breast Neoplasms
48 Citations (Scopus)

ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst

Radke, J. B., Lucas, O., De Silva, E. K., Ma, Y., Sullivan, W. J., Weiss, L. M., Llinas, M. & White, M. W., Apr 23 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6871-6876 6 p.

Research output: Contribution to journalArticle

Transcription Factor AP-2
Toxoplasma
Cysts
Antigens
Messenger RNA

A plasma membrane localized protein phosphatase in Toxoplasma gondii, PPM5C, regulates attachment to host cells

Yang, C., Broncel, M., Dominicus, C., Sampson, E., Blakely, W. J., Treeck, M. & Arrizabalaga, G., Dec 1 2019, In : Scientific Reports. 9, 1, 5924.

Research output: Contribution to journalArticle

Open Access
Phosphoprotein Phosphatases
Toxoplasma
Blood Proteins
Membrane Proteins
Parasites
4 Citations (Scopus)

A Radioimmunoassay for Serum Calcitonin in the Rat (39430)

Bell, N. H. & Queener, S. F., Sep 1976, In : Proceedings of the Society for Experimental Biology and Medicine. 152, 4, p. 516-519 4 p.

Research output: Contribution to journalArticle

Calcitonin
Radioimmunoassay
Rats
Serum
Assays
18 Citations (Scopus)

A rapid and simple HPLC microassay for biogenic amines in discrete brain regions

Donzanti, B. A. & Yamamoto, B. K., Jul 1988, In : Pharmacology, Biochemistry and Behavior. 30, 3, p. 795-799 5 p.

Research output: Contribution to journalArticle

Biogenic Amines
Metabolites
Assays
Brain
Particle size
60 Citations (Scopus)

A rapid oxidation and persistent decrease in the vesicular monoamine transporter 2 after methamphetamine

Eyerman, D. J. & Yamamoto, B. K., Nov 1 2007, In : Journal of Neurochemistry. 103, 3, p. 1219-1227 9 p.

Research output: Contribution to journalArticle

Vesicular Monoamine Transport Proteins
Methamphetamine
Oxidation
Dopamine
Nitric Oxide Synthase Type I
42 Citations (Scopus)

Arginine-specific reagents remove sodium channel inactivation

Eaton, D. C., Brodwick, M. S., Oxford, G. S. & Rudy, B., Dec 1 1978, In : Nature. 271, 5644, p. 473-476 4 p.

Research output: Contribution to journalArticle

Sodium Channels
Arginine
Sodium
Phenylglyoxal
Glyoxal
4 Citations (Scopus)

Aromatase inhibitors augment nociceptive behaviors in rats and enhance the excitability of sensory neurons

Robarge, J. D., Duarte, D. B., Shariati, B., Wang, R., Flockhart, D. A. & Vasko, M., Jul 1 2016, In : Experimental Neurology. 281, p. 53-65 13 p.

Research output: Contribution to journalArticle

letrozole
Aromatase Inhibitors
Sensory Receptor Cells
Hypersensitivity
exemestane
86 Citations (Scopus)
N-Methyl-3,4-methylenedioxyamphetamine
Hydroxyl Radical
Ascorbic Acid
Serotonin
Brain
33 Citations (Scopus)

A selective screen reveals discrete functional domains in Drosophila Nanos

Arrizabalaga, G. & Lehmann, R., Dec 1 1999, In : Genetics. 153, 4, p. 1825-1838 14 p.

Research output: Contribution to journalArticle

Drosophila
Germ Cells
Oogenesis
Zinc Fingers
Proteins
2 Citations (Scopus)

A simple method for scanning electron microscope preparation of cells grown in multiwell culture plates

Safa, A. R. & Tseng, M. T., Jan 1 1982, In : Biotechnic and Histochemistry. 57, 2, p. 107-112 6 p.

Research output: Contribution to journalArticle

Electrons
Artifacts
Plastics
Electron Scanning Microscopy
Buffers
284 Citations (Scopus)

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

Rush, A. M., Dib-Hajj, S. D., Liu, S., Cummins, T. R., Black, J. A. & Waxman, S. G., May 23 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 21, p. 8245-8250 6 p.

Research output: Contribution to journalArticle

Sodium Channels
Neurons
Mutation
Erythromelalgia
Ion Channels
59 Citations (Scopus)

A small molecule compound targeting STAT3 DNA-binding domain inhibits cancer cell proliferation, migration, and invasion

Huang, W., Dong, Z., Wang, F., Peng, H., Liu, J. Y. & Zhang, J. T., May 16 2014, In : ACS chemical biology. 9, 5, p. 1188-1196 9 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Cell proliferation
Cell Movement
Cell Proliferation
Molecules
Honduras
Malaria
Insecticides
Central America
Cross-Sectional Studies
167 Citations (Scopus)

Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein

Smith, F. D., Oxford, G. S. & Milgram, S. L., Jul 9 1999, In : Journal of Biological Chemistry. 274, 28, p. 19894-19900 7 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Dopamine D2 Receptors
Proteins
PDZ Domains
Actins
1 Citation (Scopus)

Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells

VanderWall, K. B., Vij, R., Ohlemacher, S. K., Sridhar, A., Fligor, C. M., Feder, E. M., Edler, M. C., Baucum, A. J., Cummins, T. R. & Meyer, J. S., Feb 12 2019, In : Stem Cell Reports. 12, 2, p. 201-212 12 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Retinal Ganglion Cells
Stem cells
Astrocytes
Brain
55 Citations (Scopus)

Asymmetric dopamine and serotonin metabolism in nigrostriatal and limbic structures of the trained circling rat

Yamamoto, B. K. & Freed, C. R., Apr 9 1984, In : Brain research. 297, 1, p. 115-119 5 p.

Research output: Contribution to journalArticle

Dopamine
Serotonin
Substantia Nigra
Amygdala
Nucleus Accumbens
7 Citations (Scopus)
Dopamine
Electrodes
Corpus Striatum
Dextroamphetamine
In Vitro Techniques
15 Citations (Scopus)

A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch

Ramsden, C. E., Domenichiello, A. F., Yuan, Z. X., Sapio, M. R., Keyes, G. S., Mishra, S. K., Gross, J. R., Majchrzak-Hong, S., Zamora, D., Horowitz, M. S., Davis, J. M., Sorokin, A. V., Dey, A., LaPaglia, D. M., Wheeler, J. J., Vasko, M., Mehta, N. N., Mannes, A. J. & Iadarola, M. J., Aug 22 2017, In : Science Signaling. 10, 493, 5241.

Research output: Contribution to journalArticle

Linoleic Acid
Systems Analysis
Skin
Derivatives
Rats
16 Citations (Scopus)

A Toxoplasma gondii mutant defective in responding to calcium fluxes shows reduced in vivo pathogenicity

Lavine, M. D., Knoll, L. J., Rooney, P. J. & Arrizabalaga, G., Oct 1 2007, In : Molecular and Biochemical Parasitology. 155, 2, p. 113-122 10 p.

Research output: Contribution to journalArticle

Toxoplasma
Virulence
Parasites
Calcium
Ionophores
18 Citations (Scopus)

A Toxoplasma gondii protein with homology to intracellular type Na+/H+ exchangers is important for osmoregulation and invasion

Francia, M. E., Wicher, S., Pace, D. A., Sullivan, J., Moreno, S. N. J. & Arrizabalaga, G., Jun 10 2011, In : Experimental Cell Research. 317, 10, p. 1382-1396 15 p.

Research output: Contribution to journalArticle

Osmoregulation
Sodium-Hydrogen Antiporter
Toxoplasma
Vacuoles
Proteins
35 Citations (Scopus)

ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors

Huang, H., Wu, X., Nicol, G. D., Meller, S. & Vasko, M. R., Sep 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 3, p. 1137-1144 8 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Adenosine Triphosphate
Peptides
Capsaicin
Protein Kinase C
25 Citations (Scopus)

ATP-sensitive potassium currents reduce the PGE2-mediated enhancement of excitability in adult rat sensory neurons

Chi, X. X., Jiang, X. & Nicol, G. D., May 11 2007, In : Brain research. 1145, 1, p. 28-40 13 p.

Research output: Contribution to journalArticle

Diazoxide
Sensory Receptor Cells
Dinoprostone
Potassium
Adenosine Triphosphate