Pharmacology & Toxicology

Publications 1971 2020

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2014
5 Citations (Scopus)

Characterization of TgPuf1, a member of the Puf family RNA-binding proteins from Toxoplasma gondii

Liu, M., Miao, J., Liu, T., Sullivan, W., Cui, L. & Chen, X., Mar 31 2014, In : Parasites and Vectors. 7, 1, 141.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Toxoplasma
Parasites
RNA
Proteins
36 Citations (Scopus)

Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity

Brustovetsky, T., Pellman, J. J., Yang, X. F., Khanna, R. & Broustovetski, N., Mar 14 2014, In : Journal of Biological Chemistry. 289, 11, p. 7470-7482 13 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Sodium-Calcium Exchanger
Neurons
Glutamic Acid
Proteins
58 Citations (Scopus)

Critical role of NF-κB in pancreatic cancer

Prabhu, L., Mundade, R., Korc, M., Loehrer, P. & Lu, T., 2014, In : Oncotarget. 5, 22, p. 10969-10975 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Mutation Rate
Therapeutics
Mutation
6 Citations (Scopus)

DHA2, a synthesized derivative of bisbibenzyl, exerts antitumor activity against ovarian cancer through inhibition of XIAP and Akt/mTOR pathway

Pang, Y., Si, M., Sun, B., Niu, L., Xu, X., Lu, T., Yuan, H. & Lou, H., 2014, In : Food and Chemical Toxicology. 69, p. 163-174 12 p.

Research output: Contribution to journalArticle

X-Linked Inhibitor of Apoptosis Protein
ovarian neoplasms
Cell death
Ovarian Neoplasms
cell death
16 Citations (Scopus)

EIF3i promotes colon oncogenesis by regulating COX-2 protein synthesis and β-catenin activation

Qi, J., Dong, Z., Liu, J. & Zhang, J-T., Aug 7 2014, In : Oncogene. 33, 32, p. 4156-4163 8 p.

Research output: Contribution to journalArticle

Catenins
Cyclooxygenase 2
Colon
Carcinogenesis
Eukaryotic Initiation Factors
9 Citations (Scopus)

Expression of the essential kinase PFCDPK1 from plasmodium falciparum in toxoplasma gondii facilitates the discovery of novel antimalarial drugs

Gaji, R. Y., Checkley, L., Reese, M. L., Ferdig, M. T. & Arrizabalaga, G., 2014, In : Antimicrobial Agents and Chemotherapy. 58, 5, p. 2598-2607 10 p.

Research output: Contribution to journalArticle

Toxoplasma
Antimalarials
Plasmodium falciparum
Phosphotransferases
Merozoites
8 Citations (Scopus)

Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma

Lakhter, A. J., Hamilton, J., Dagher, P., Mukkamala, S., Hato, T., Dong, X., Mayo, L., Harris, R., Shekhar, A., Ivan, M., Broustovetski, N. & Naidu, S., 2014, In : Oncotarget. 5, 24, p. 12694-12703 10 p.

Research output: Contribution to journalArticle

Vitamin K 3
Oxidative Phosphorylation
Glycolysis
Melanoma
Cell Death
20 Citations (Scopus)

Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel

Chen, X., Sun, W., Gianaris, N. G., Riley, A. M., Cummins, T., Fehrenbacher, J. & Obukhov, A., Apr 4 2014, In : Journal of Biological Chemistry. 289, 14, p. 9600-9610 11 p.

Research output: Contribution to journalArticle

Modulators
Capsaicin
Chemical activation
Eye Pain
Toothache
21 Citations (Scopus)

Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins

Xiao, Y., Blumenthal, K. & Cummins, T., 2014, In : Molecular Pharmacology. 86, 2, p. 159-167 9 p.

Research output: Contribution to journalArticle

Biological Toxins
Sodium Channels
Sea Anemones
Voltage-Gated Sodium Channels
Ion Channels
14 Citations (Scopus)

GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii

Konrad, C., Wek, R. & Sullivan, W., Feb 2014, In : International Journal for Parasitology. 44, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Eukaryotic Initiation Factors
Toxoplasma
Starvation
Parasites
48 Citations (Scopus)

Genetic pathways, prevention, and treatment of sporadic colorectal cancer

Mundade, R., Imperiale, T., Prabhu, L., Loehrer, P. & Lu, T., 2014, In : Oncoscience. 1, 6, p. 400-406 7 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Epigenomics
Colonic Neoplasms
Therapeutics
Neoplasms
7 Citations (Scopus)

Interleukin-driven insulin-like growth factor promotes prostatic inflammatory hyperplasia

Hahn, A. M., Myers, J. D., McFarland, E. K., Lee, S. & Jerde, T., Dec 1 2014, In : Journal of Pharmacology and Experimental Therapeutics. 351, 3, p. 606-615 10 p.

Research output: Contribution to journalArticle

Interleukins
Prostatic Hyperplasia
Somatomedins
Inflammation
Prostatic Neoplasms
6 Citations (Scopus)

Intraganglionic signaling as a novel nasal-meningeal pathway for TRPA1-dependent trigeminovascular activation by inhaled environmental irritants

Kunkler, P. E., Ballard, C. J., Pellman, J. J., Zhang, L., Oxford, G. S. & Hurley, J., Jul 31 2014, In : PLoS One. 9, 7, e103086.

Research output: Contribution to journalArticle

Irritants
Nose
Intranasal Administration
Trigeminal Ganglion
Neurons
29 Citations (Scopus)

Lysine Acetyltransferase GCN5b Interacts with AP2 Factors and Is Required for Toxoplasma gondii Proliferation

Wang, J., Dixon, S. E., Ting, L. M., Liu, T. K., Jeffers, V., Croken, M. M., Calloway, M., Cannella, D., Ali Hakimi, M., Kim, K. & Sullivan, W., Jan 2014, In : PLoS Pathogens. 10, 1, e1003830.

Research output: Contribution to journalArticle

Toxoplasma
Parasites
Histones
Acetylation
Gene Expression
11 Citations (Scopus)

Mechanism of orlistat hydrolysis by the thioesterase of human fatty acid synthase

Fako, V. E., Zhang, J-T. & Liu, J. Y., Oct 3 2014, In : ACS Catalysis. 4, 10, p. 3444-3453 10 p.

Research output: Contribution to journalArticle

Fatty acids
Hydrolysis
Hydrogen bonds
Chemical activation
Water
33 Citations (Scopus)

Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage

Cleaver, J. E., Brennan-Minnella, A. M., Swanson, R. A., Fong, K. W., Chen, J., Chou, K. M., Chen, Y. W., Revet, I. & Bezrookove, V., Sep 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 37, p. 13487-13492 6 p.

Research output: Contribution to journalArticle

Cockayne Syndrome
DNA Damage
Reactive Oxygen Species
Fibroblasts
Staphylococcal Protein A
30 Citations (Scopus)

Molecular mechanisms of fatty acid synthase (FASN)-mediated resistance to anti-cancer treatments

Wu, X., Qin, L., Fako, V. & Zhang, J-T., 2014, In : Advances in Biological Regulation. 54, 1, p. 214-221 8 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Drug Resistance
Neoplasms
Radiation
Apoptosis Regulatory Proteins
10 Citations (Scopus)

Nerve growth factor mediates a switch in intracellular signaling for PGE<inf>2</inf>-induced sensitization of sensory neurons from protein kinase A to Epac

Vasko, M., Habashy Malty, R., Guo, C., Duarte, D. B., Zhang, Y. & Nicol, G., Aug 15 2014, In : PLoS One. 9, 8, e104529.

Research output: Contribution to journalArticle

nerve growth factor
cAMP-dependent protein kinase
sensory neurons
Nerve Growth Factor
Sensory Receptor Cells
9 Citations (Scopus)

N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1 +/- mice

Duan, J. H., Hodgdon, K. E., Hingtgen, C. M. & Nicol, G., Jun 13 2014, In : Neuroscience. 270, p. 192-202 11 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Calcium
Calcitonin Gene-Related Peptide
Genotype
Substance P
12 Citations (Scopus)

Paclitaxel alters the evoked release of calcitonin gene-related peptide from rat sensory neurons in culture

Pittman, S. K., Gracias, N. G., Vasko, M. & Fehrenbacher, J., Mar 2014, In : Experimental Neurology. 253, p. 146-153 8 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
Sensory Receptor Cells
Paclitaxel
Capsaicin
Peripheral Nervous System Diseases
2 Citations (Scopus)

Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons

Balsara, R. D., Ferreira, A. N., Donahue, D. L., Castellino, F. J. & Sheets, P., Apr 2014, In : Neuropharmacology. 79, p. 542-549 8 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
N-Methyl-D-Aspartate Receptors
Neurons
Pyramidal Cells
Glutamic Acid
22 Citations (Scopus)

Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation

Selvaraj, N., Budka, J. A., Ferris, M. W., Jerde, T. & Hollenhorst, P., Mar 19 2014, In : Molecular Cancer. 13, 1, 61.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Cell Movement
Prostatic Neoplasms
Gene Expression
Mutation
90 Citations (Scopus)

Protein arginine methylation of non-histone proteins and its role in diseases

Wei, H., Mundade, R., Lange, K. C. & Lu, T., Jan 1 2014, In : Cell Cycle. 13, 1, p. 32-41 10 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Methylation
Arginine
Proteins
Post Translational Protein Processing
11 Citations (Scopus)

Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker

Tan, Z. Y., Priest, B. T., Krajewski, J. L., Knopp, K. L., Nisenbaum, E. S. & Cummins, T., Nov 3 2014, In : FEBS Letters. 588, 21, p. 3964-3969 6 p.

Research output: Contribution to journalArticle

Sodium Channels
Phosphorylation
Serine
Protein Kinase C
Sodium
13 Citations (Scopus)

Reversible epigenetic regulation of 14-3-3σ expression in acquired gemcitabine resistance by uhrf1 and DNA methyltransferase 1

Qin, L., Dong, Z. & Zhang, J-T., Nov 1 2014, In : Molecular Pharmacology. 86, 5, p. 561-569 9 p.

Research output: Contribution to journalArticle

gemcitabine
Methyltransferases
Epigenomics
DNA
Pancreatic Neoplasms
49 Citations (Scopus)

Role of ChIP-seq in the discovery of transcription factor binding sites, differential gene regulation mechanism, epigenetic marks and beyond

Mundade, R., Ozer, H. G., Wei, H., Prabhu, L. & Lu, T., Sep 15 2014, In : Cell Cycle. 13, 18, p. 2847-2852 6 p.

Research output: Contribution to journalArticle

Chromatin Immunoprecipitation
Epigenomics
Transcription Factors
Binding Sites
Genes
47 Citations (Scopus)

Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy

Kelley, M., Jiang, Y., Guo, C., Reed, A., Meng, H. & Vasko, M., Sep 4 2014, In : PLoS One. 9, 9, e106485.

Research output: Contribution to journalArticle

oxaliplatin
DNA-(Apurinic or Apyrimidinic Site) Lyase
cisplatin
peripheral nervous system diseases
Carboplatin
6 Citations (Scopus)

Substituted N -(biphenyl-4′-yl)methyl (R)-2-acetamido-3- methoxypropionamides: Potent anticonvulsants that affect frequency (Use) dependence and slow inactivation of sodium channels

Lee, H., Park, K. D., Torregrosa, R., Yang, X. F., Dustrude, E. T., Wang, Y., Wilson, S. M., Barbosa, C., Xiao, Y., Cummins, T., Khanna, R. & Kohn, H., Jul 24 2014, In : Journal of Medicinal Chemistry. 57, 14, p. 6165-6182 18 p.

Research output: Contribution to journalArticle

Sodium Channels
Anticonvulsants
Rodentia
Pharmacology
Pharmaceutical Preparations
12 Citations (Scopus)

Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury

Ploplis, V. A., Donahue, D. L., Sandoval-Cooper, M. J., Morenocaffaro, M., Sheets, P., Thomas, S. G., Walsh, M. & Castellino, F. J., Oct 1 2014, In : Journal of Neurotrauma. 31, 19, p. 1672-1675 4 p.

Research output: Contribution to journalArticle

Platelet Activation
Blood Platelets
Brain
Adenosine Diphosphate
Thrombelastography
29 Citations (Scopus)

Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators

Tan, Z. Y., Piekarz, A. D., Priest, B. T., Knopp, K. L., Krajewski, J. L., McDermott, J. S., Nisenbaum, E. S. & Cummins, T., 2014, In : Journal of Neuroscience. 34, 21, p. 7190-7197 8 p.

Research output: Contribution to journalArticle

Sodium Channels
Tetrodotoxin
Spinal Ganglia
Sensory Receptor Cells
Neurons
31 Citations (Scopus)

The Calcium-Dependent Protein Kinase 3 of Toxoplasma Influences Basal Calcium Levels and Functions beyond Egress as Revealed by Quantitative Phosphoproteome Analysis

Treeck, M., Sanders, J. L., Gaji, R. Y., LaFavers, K. A., Child, M. A., Arrizabalaga, G., Elias, J. E. & Boothroyd, J. C., 2014, In : PLoS Pathogens. 10, 6, e1004197.

Research output: Contribution to journalArticle

Toxoplasma
Parasites
Calcium
Phosphotransferases
Phosphorylation
9 Citations (Scopus)
P-Glycoproteins
Dopaminergic Neurons
Caenorhabditis elegans
Neurons
Toxicity
2013
48 Citations (Scopus)

ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst

Radke, J. B., Lucas, O., De Silva, E. K., Ma, Y., Sullivan, W., Weiss, L. M., Llinas, M. & White, M. W., Apr 23 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6871-6876 6 p.

Research output: Contribution to journalArticle

Transcription Factor AP-2
Toxoplasma
Cysts
Antigens
Messenger RNA
32 Citations (Scopus)

Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; Application of buchwald-hartwig aminations of heterocycles

Gangjee, A., Namjoshi, O. A., Raghavan, S., Queener, S., Kisliuk, R. L. & Cody, V., Jun 13 2013, In : Journal of Medicinal Chemistry. 56, 11, p. 4422-4441 20 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Amination
Pneumocystis carinii
Mycobacterium avium
Opportunistic Infections
8 Citations (Scopus)

Determinants of 14-3-3σ protein dimerization and function in drug and radiation resistance

Li, Z., Peng, H., Qin, L., Qi, J., Zuo, X., Liu, J. Y. & Zhang, J-T., Nov 1 2013, In : Journal of Biological Chemistry. 288, 44, p. 31447-31457 11 p.

Research output: Contribution to journalArticle

Protein Multimerization
14-3-3 Proteins
Dimerization
Drug Resistance
Radiation
14 Citations (Scopus)

Discovery of potent and selective inhibitors of toxoplasma gondii thymidylate synthase for opportunistic infections

Zaware, N., Sharma, H., Yang, J., Devambatla, R. K. V., Queener, S., Anderson, K. S. & Gangjee, A., Dec 12 2013, In : ACS Medicinal Chemistry Letters. 4, 12, p. 1148-1151 4 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Toxoplasmosis
Opportunistic Infections
Toxoplasma
Indoles
27 Citations (Scopus)

eGFP expression under UCHL1 promoter genetically labels corticospinal motor neurons and a subpopulation of degeneration-resistant spinal motor neurons in an ALS mouse model

Yasvoina, M. V., Genç, B., Jara, J. H., Sheets, P., Quinlan, K. A., Milosevic, A., Shepherd, G. M. G., Heckman, C. J. & Özdinler, P. H., 2013, In : Journal of Neuroscience. 33, 18, p. 7890-7904 15 p.

Research output: Contribution to journalArticle

Motor Neurons
Dendrites
Motor Cortex
Neurons
Genetic Hybridization
15 Citations (Scopus)

Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in toxoplasma gondii

Stilger, K. L. & Sullivan, W., Aug 30 2013, In : Journal of Biological Chemistry. 288, 35, p. 25318-25329 12 p.

Research output: Contribution to journalArticle

Acetyltransferases
Mitochondrial Proteins
Toxoplasma
Lysine
Mitochondria
27 Citations (Scopus)

Expression of DNA translesion synthesis polymerase η in head and neck squamous cell cancer predicts resistance to gemcitabine and cisplatin-based chemotherapy

Zhou, W., Chen, Y. W., Liu, X., Chu, P., Loria, S., Wang, Y., Yen, Y. & Chou, K. M., Dec 20 2013, In : PLoS One. 8, 12, e83978.

Research output: Contribution to journalArticle

gemcitabine
Squamous Cell Neoplasms
cisplatin
Chemotherapy
Head and Neck Neoplasms
46 Citations (Scopus)

Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development

Miao, J., Lawrence, M., Jeffers, V., Zhao, F., Parker, D., Ge, Y., Sullivan, W. & Cui, L., Aug 2013, In : Molecular Microbiology. 89, 4, p. 660-675 16 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Acetylation
Metabolic Networks and Pathways
Lysine
Parasites
29 Citations (Scopus)

Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production

Liu, H., Wu, X., Dong, Z., Luo, Z., Zhao, Z., Xu, Y. & Zhang, J-T., Mar 2013, In : Journal of Lipid Research. 54, 3, p. 776-785 10 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Ceramides
Drug Resistance
Pharmaceutical Preparations
Chemical activation
18 Citations (Scopus)

Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii

Konrad, C., Queener, S., Wek, R. & Sullivan, W., Apr 2013, In : Antimicrobial Agents and Chemotherapy. 57, 4, p. 1815-1822 8 p.

Research output: Contribution to journalArticle

Guanabenz
Eukaryotic Initiation Factor-2
Toxoplasma
Parasites
Phosphorylation
10 Citations (Scopus)
Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Catalytic Domain
Trimethoprim
8 Citations (Scopus)

Methylmercury exposure increases lipocalin related (lpr) and decreases activated in blocked unfolded protein response (abu) genes and specific mirnas in caenorhabditis elegans

Rudgalvyte, M., VanDuyn, N., Aarnio, V., Heikkinen, L., Peltonen, J., Lakso, M., Nass, R. & Wong, G., Oct 4 2013, In : Toxicology Letters. 222, 2, p. 189-196 8 p.

Research output: Contribution to journalArticle

Lipocalins
Unfolded Protein Response
Caenorhabditis elegans
MicroRNAs
Genes
8 Citations (Scopus)

MirNAS and their putative roles in the development and progression of Parkinson's disease

Wong, G. & Nass, R., 2013, In : Frontiers in Genetics. 3, JAN, Article 315.

Research output: Contribution to journalArticle

MicroRNAs
Parkinson Disease
Disease Progression
Untranslated RNA
Data Mining
5 Citations (Scopus)

Nerve growth factor/p75 neurotrophin receptor-mediated sensitization of rat sensory neurons depends on membrane cholesterol

Zhang, Y. H., Khanna, R. & Nicol, G., Sep 17 2013, In : Neuroscience. 248, p. 562-570 9 p.

Research output: Contribution to journalArticle

Nerve Growth Factor Receptor
Nerve Growth Factor
Sensory Receptor Cells
Cholesterol
Membranes
26 Citations (Scopus)

NPY y 1 receptors differentially modulate gaba a and nmda receptors via divergent signal-transduction pathways to reduce excitability of amygdala neurons

Molosh, A. I., Sajdyk, T. J., Truitt, W., Zhu, W., Oxford, G. S. & Shekhar, A., Jun 2013, In : Neuropsychopharmacology. 38, 7, p. 1352-1364 13 p.

Research output: Contribution to journalArticle

N-Methylaspartate
Amygdala
Signal Transduction
gamma-Aminobutyric Acid
Inhibitory Postsynaptic Potentials
13 Citations (Scopus)

Overexpression of asparagine synthetase and matrix metalloproteinase 19 confers cisplatin sensitivity in nasopharyngeal carcinoma cells

Liu, R. Y., Dong, Z., Liu, J., Zhou, L., Huang, W., Khoo, S. K., Zhang, Z., Petillo, D., Teh, B. T., Qian, C. N. & Zhang, J-T., Oct 2013, In : Molecular Cancer Therapeutics. 12, 10, p. 2157-2166 10 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
Cisplatin
Chorionic Gonadotropin
Platinum
Gene Expression Profiling
38 Citations (Scopus)

Perturbations of PlasmodiumPuf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility

Lindner, S. E., Mikolajczak, S. A., Vaughan, A. M., Moon, W., Joyce, B. R., Sullivan, W. & Kappe, S. H. I., Jul 2013, In : Cellular Microbiology. 15, 7, p. 1266-1283 18 p.

Research output: Contribution to journalArticle

Sporozoites
Parasites
Homeostasis
RNA
Salivary Glands
35 Citations (Scopus)

PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.

Zhang, T., Park, K. A., Li, Y., Byun, H. S., Jeon, J., Lee, Y., Hong, J. H., Kim, J. M., Huang, S. M., Choi, S. W., Kim, S. H., Sohn, K. C., Ro, H., Lee, J. H., Lu, T., Stark, G. R., Shen, H. M., Liu, Z. G., Park, J. & Hur, G. M., 2013, In : Nature Communications. 4, 2062.

Research output: Contribution to journalArticle

Homeodomain Proteins
disrupting
Plant Proteins
proteins
Proteins