Pharmacology & Toxicology

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2015

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

Herman, J. D., Pepper, L. R., Cortese, J. F., Estiu, G., Galinsky, K., Zuzarte-Luis, V., Derbyshire, E. R., Ribacke, U., Lukens, A. K., Santos, S. A., Patel, V., Clish, C. B., Sullivan, W. J., Zhou, H., Bopp, S. E., Schimmel, P., Lindquist, S., Clardy, J., Mota, M. M., Keller, T. L. & 4 others, Whitman, M., Wiest, O., Wirth, D. F. & Mazitschek, R., May 20 2015, In : Science translational medicine. 7, 288

Research output: Contribution to journalArticle

28 Scopus citations

Using Sequential Immunoprecipitation and Mass Spectrometry to Identify Methylation of NF-κB

Lu, T. & Stark, G. R., Jan 1 2015, In : Methods in Molecular Biology. 1280, p. 383-393 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Ammonia mediates methamphetamine-induced increases in glutamate and excitotoxicity

Halpin, L. E., Northrop, N. A. & Yamamoto, B. K., Mar 1 2014, In : Neuropsychopharmacology. 39, 4, p. 1031-1038 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

A small molecule compound targeting STAT3 DNA-binding domain inhibits cancer cell proliferation, migration, and invasion

Huang, W., Dong, Z., Wang, F., Peng, H., Liu, J. Y. & Zhang, J. T., May 16 2014, In : ACS chemical biology. 9, 5, p. 1188-1196 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Canonical histone H2Ba and H2A.X dimerize in an opposite genomic localization to H2A.Z/H2B.Z dimers in Toxoplasma gondii

Bogado, S. S., Dalmasso, M. C., Ganuza, A., Kim, K., Sullivan, W. J., Angel, S. O. & Vanagas, L., Oct 2014, In : Molecular and Biochemical Parasitology. 197, 1-2, p. 36-42 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Characterization of TgPuf1, a member of the Puf family RNA-binding proteins from Toxoplasma gondii

Liu, M., Miao, J., Liu, T., Sullivan, W. J., Cui, L. & Chen, X., Mar 31 2014, In : Parasites and Vectors. 7, 1, 141.

Research output: Contribution to journalArticle

5 Scopus citations

Chronic L-Dopa decreases serotonin neurons in a subregion of the dorsal raphe nucleus

Stansley, B. J. & Yamamoto, B. K., Nov 1 2014, In : Journal of Pharmacology and Experimental Therapeutics. 351, 2, p. 440-447 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity

Brustovetsky, T., Pellman, J. J., Yang, X. F., Khanna, R. & Brustovetsky, N., Mar 14 2014, In : Journal of Biological Chemistry. 289, 11, p. 7470-7482 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

DHA2, a synthesized derivative of bisbibenzyl, exerts antitumor activity against ovarian cancer through inhibition of XIAP and Akt/mTOR pathway

Pang, Y., Si, M., Sun, B., Niu, L., Xu, X., Lu, T., Yuan, H. & Lou, H., Jul 2014, In : Food and Chemical Toxicology. 69, p. 163-174 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effects of stress and MDMA on hippocampal gene expression

Weber, G. F., Johnson, B. N., Yamamoto, B. K. & Gudelsky, G. A., Feb 5 2014, In : BioMed research international. 2014, 141396.

Research output: Contribution to journalArticle

10 Scopus citations

EIF3i promotes colon oncogenesis by regulating COX-2 protein synthesis and β-catenin activation

Qi, J., Dong, Z., Liu, J. & Zhang, J. T., Aug 7 2014, In : Oncogene. 33, 32, p. 4156-4163 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Enhanced brain distribution of modified aspartoacylase

Poddar, N. K., Zano, S., Natarajan, R., Yamamoto, B. & Viola, R. E., Nov 1 2014, In : Molecular Genetics and Metabolism. 113, 3, p. 219-224 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Expression of the essential kinase PFCDPK1 from plasmodium falciparum in toxoplasma gondii facilitates the discovery of novel antimalarial drugs

Gaji, R. Y., Checkley, L., Reese, M. L., Ferdig, M. T. & Arrizabalaga, G., May 2014, In : Antimicrobial Agents and Chemotherapy. 58, 5, p. 2598-2607 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma

Lakhter, A. J., Hamilton, J., Dagher, P. C., Mukkamala, S., Hato, T., Dong, X. C., Mayo, L. D., Harris, R. A., Shekhar, A., Ivan, M., Brustovetsky, N. & Naidu, S. R., Jan 1 2014, In : Oncotarget. 5, 24, p. 12694-12703 10 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel

Chen, X., Sun, W., Gianaris, N. G., Riley, A. M., Cummins, T. R., Fehrenbacher, J. C. & Obukhov, A. G., Apr 4 2014, In : Journal of Biological Chemistry. 289, 14, p. 9600-9610 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins

Xiao, Y., Blumenthal, K. & Cummins, T. R., Aug 2014, In : Molecular pharmacology. 86, 2, p. 159-167 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii

Konrad, C., Wek, R. C. & Sullivan, W. J., Feb 1 2014, In : International Journal for Parasitology. 44, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Genetic pathways, prevention, and treatment of sporadic colorectal cancer

Mundade, R., Imperiale, T. F., Prabhu, L., Loehrer, P. J. & Lu, T., Jan 1 2014, In : Oncoscience. 1, 6, p. 400-406 7 p.

Research output: Contribution to journalArticle

52 Scopus citations

Interleukin-driven insulin-like growth factor promotes prostatic inflammatory hyperplasia

Hahn, A. M., Myers, J. D., McFarland, E. K., Lee, S. & Jerde, T. J., Dec 1 2014, In : Journal of Pharmacology and Experimental Therapeutics. 351, 3, p. 606-615 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Intraganglionic signaling as a novel nasal-meningeal pathway for TRPA1-dependent trigeminovascular activation by inhaled environmental irritants

Kunkler, P. E., Ballard, C. J., Pellman, J. J., Zhang, L. J., Oxford, G. S. & Hurley, J. H., Jul 31 2014, In : PLoS ONE. 9, 7, e103086.

Research output: Contribution to journalArticle

6 Scopus citations

Lysine Acetyltransferase GCN5b Interacts with AP2 Factors and Is Required for Toxoplasma gondii Proliferation

Wang, J., Dixon, S. E., Ting, L. M., Liu, T. K., Jeffers, V., Croken, M. M., Calloway, M., Cannella, D., Ali Hakimi, M., Kim, K. & Sullivan, W. J., Jan 1 2014, In : PLoS pathogens. 10, 1, e1003830.

Research output: Contribution to journalArticle

29 Scopus citations

Mechanism of orlistat hydrolysis by the thioesterase of human fatty acid synthase

Fako, V. E., Zhang, J. T. & Liu, J. Y., Oct 3 2014, In : ACS Catalysis. 4, 10, p. 3444-3453 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage

Cleaver, J. E., Brennan-Minnella, A. M., Swanson, R. A., Fong, K. W., Chen, J., Chou, K. M., Chen, Y. W., Revet, I. & Bezrookove, V., Sep 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 37, p. 13487-13492 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Nerve growth factor mediates a switch in intracellular signaling for PGE2-induced sensitization of sensory neurons from protein kinase A to Epac

Vasko, M. R., Habashy Malty, R., Guo, C., Duarte, D. B., Zhang, Y. & Nicol, G. D., Aug 15 2014, In : PLoS ONE. 9, 8, e104529.

Research output: Contribution to journalArticle

12 Scopus citations

N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1 +/- mice

Duan, J. H., Hodgdon, K. E., Hingtgen, C. M. & Nicol, G. D., Jun 13 2014, In : Neuroscience. 270, p. 192-202 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Paclitaxel alters the evoked release of calcitonin gene-related peptide from rat sensory neurons in culture

Pittman, S. K., Gracias, N. G., Vasko, M. R. & Fehrenbacher, J. C., Mar 1 2014, In : Experimental Neurology. 253, p. 146-153 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons

Balsara, R. D., Ferreira, A. N., Donahue, D. L., Castellino, F. J. & Sheets, P. L., Apr 1 2014, In : Neuropharmacology. 79, p. 542-549 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation

Selvaraj, N., Budka, J. A., Ferris, M. W., Jerde, T. J. & Hollenhorst, P. C., Mar 19 2014, In : Molecular Cancer. 13, 1, 61.

Research output: Contribution to journalArticle

23 Scopus citations

Protein arginine methylation of non-histone proteins and its role in diseases

Wei, H., Mundade, R., Lange, K. C. & Lu, T., Jan 1 2014, In : Cell Cycle. 13, 1, p. 32-41 10 p.

Research output: Contribution to journalArticle

95 Scopus citations

Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker

Tan, Z. Y., Priest, B. T., Krajewski, J. L., Knopp, K. L., Nisenbaum, E. S. & Cummins, T. R., Nov 3 2014, In : FEBS Letters. 588, 21, p. 3964-3969 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Reversible epigenetic regulation of 14-3-3σ expression in acquired gemcitabine resistance by Uhrf1 and DNA methyltransferase 1

Qin, L., Dong, Z. & Zhang, J. T., Jan 1 2014, In : Molecular pharmacology. 86, 5, p. 561-569 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy

Kelley, M. R., Jiang, Y., Guo, C., Reed, A., Meng, H. & Vasko, M. R., Sep 4 2014, In : PLoS ONE. 9, 9, e106485.

Research output: Contribution to journalArticle

51 Scopus citations

Substituted N -(biphenyl-4′-yl)methyl (R)-2-acetamido-3- methoxypropionamides: Potent anticonvulsants that affect frequency (Use) dependence and slow inactivation of sodium channels

Lee, H., Park, K. D., Torregrosa, R., Yang, X. F., Dustrude, E. T., Wang, Y., Wilson, S. M., Barbosa, C., Xiao, Y., Cummins, T. R., Khanna, R. & Kohn, H., Jul 24 2014, In : Journal of Medicinal Chemistry. 57, 14, p. 6165-6182 18 p.

Research output: Contribution to journalArticle

6 Scopus citations

Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury

Ploplis, V. A., Donahue, D. L., Sandoval-Cooper, M. J., Morenocaffaro, M., Sheets, P., Thomas, S. G., Walsh, M. & Castellino, F. J., Oct 1 2014, In : Journal of neurotrauma. 31, 19, p. 1672-1675 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators

Tan, Z. Y., Piekarz, A. D., Priest, B. T., Knopp, K. L., Krajewski, J. L., McDermott, J. S., Nisenbaum, E. S. & Cummins, T. R., Jan 1 2014, In : Journal of Neuroscience. 34, 21, p. 7190-7197 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

The Calcium-Dependent Protein Kinase 3 of Toxoplasma Influences Basal Calcium Levels and Functions beyond Egress as Revealed by Quantitative Phosphoproteome Analysis

Treeck, M., Sanders, J. L., Gaji, R. Y., LaFavers, K. A., Child, M. A., Arrizabalaga, G., Elias, J. E. & Boothroyd, J. C., Jun 2014, In : PLoS pathogens. 10, 6, e1004197.

Research output: Contribution to journalArticle

33 Scopus citations

The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1

Janes, K., Little, J. W., Li, C., Bryant, L., Chen, C., Chen, Z., Kamocki, K., Doyle, T., Snider, A., Esposito, E., Cuzzocrea, S., Bieberich, E., Obeid, L., Petrache, I., Nicol, G., Neumann, W. L. & Salvemini, D., Jul 25 2014, In : Journal of Biological Chemistry. 289, 30, p. 21082-21097 16 p.

Research output: Contribution to journalArticle

56 Scopus citations
9 Scopus citations
2013

ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst

Radke, J. B., Lucas, O., De Silva, E. K., Ma, Y., Sullivan, W. J., Weiss, L. M., Llinas, M. & White, M. W., Apr 23 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6871-6876 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Cyclooxygenase activity contributes to the monoaminergic damage caused by serial exposure to stress and methamphetamine

Northrop, N. A. & Yamamoto, B. K., Jan 1 2013, In : Neuropharmacology. 72, p. 96-105 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; Application of buchwald-hartwig aminations of heterocycles

Gangjee, A., Namjoshi, O. A., Raghavan, S., Queener, S. F., Kisliuk, R. L. & Cody, V., Jun 13 2013, In : Journal of Medicinal Chemistry. 56, 11, p. 4422-4441 20 p.

Research output: Contribution to journalArticle

32 Scopus citations

Determinants of 14-3-3σ protein dimerization and function in drug and radiation resistance

Li, Z., Peng, H., Qin, L., Qi, J., Zuo, X., Liu, J. Y. & Zhang, J. T., Nov 1 2013, In : Journal of Biological Chemistry. 288, 44, p. 31447-31457 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Discovery of potent and selective inhibitors of toxoplasma gondii thymidylate synthase for opportunistic infections

Zaware, N., Sharma, H., Yang, J., Devambatla, R. K. V., Queener, S. F., Anderson, K. S. & Gangjee, A., Dec 12 2013, In : ACS Medicinal Chemistry Letters. 4, 12, p. 1148-1151 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Effect of repeated exposure to MDMA on the function of the 5-HT transporter as assessed by synaptosomal 5-HT uptake

Huff, C., Bhide, N., Schroering, A., Yamamoto, B. K. & Gudelsky, G. A., Feb 1 2013, In : Brain Research Bulletin. 91, p. 52-57 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

eGFP expression under UCHL1 promoter genetically labels corticospinal motor neurons and a subpopulation of degeneration-resistant spinal motor neurons in an ALS mouse model

Yasvoina, M. V., Genç, B., Jara, J. H., Sheets, P. L., Quinlan, K. A., Milosevic, A., Shepherd, G. M. G., Heckman, C. J. & Özdinler, P. H., May 10 2013, In : Journal of Neuroscience. 33, 18, p. 7890-7904 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in toxoplasma gondii

Stilger, K. L. & Sullivan, W. J., Aug 30 2013, In : Journal of Biological Chemistry. 288, 35, p. 25318-25329 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Expression of DNA translesion synthesis polymerase η in head and neck squamous cell cancer predicts resistance to gemcitabine and cisplatin-based chemotherapy

Zhou, W., Chen, Y. W., Liu, X., Chu, P., Loria, S., Wang, Y., Yen, Y. & Chou, K. M., Dec 20 2013, In : PLoS ONE. 8, 12, e83978.

Research output: Contribution to journalArticle

28 Scopus citations

Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development

Miao, J., Lawrence, M., Jeffers, V., Zhao, F., Parker, D., Ge, Y., Sullivan, W. J. & Cui, L., Aug 1 2013, In : Molecular Microbiology. 89, 4, p. 660-675 16 p.

Research output: Contribution to journalArticle

48 Scopus citations

Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production

Liu, H., Wu, X., Dong, Z., Luo, Z., Zhao, Z., Xu, Y. & Zhang, J. T., Mar 1 2013, In : Journal of Lipid Research. 54, 3, p. 776-785 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
19 Scopus citations