Pharmacology & Toxicology

Publications 1971 2020

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2013
91 Citations (Scopus)

PRMT5 dimethylates R30 of the p65 subunit to activate NF-?B

Wei, H., Wang, B., Miyagi, M., She, Y., Gopalan, B., Huang, D. B., Ghosh, G., Stark, G. R. & Lu, T., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13516-13521 6 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Methylation
Arginine
Carcinogenesis
Gene Expression
29 Citations (Scopus)

Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii

Xue, B., Jeffers, V., Sullivan, W. & Uversky, V. N., Apr 2013, In : Molecular BioSystems. 9, 4, p. 645-657 13 p.

Research output: Contribution to journalArticle

Toxoplasma
Parasites
Lysine
Proteins
Acetylation
16 Citations (Scopus)

Spectrin domain of eukaryotic initiation factor 3a is the docking site for formation of the a: b:i:g subcomplex

Dong, Z., Qi, J., Peng, H., Liu, J. & Zhang, J-T., Sep 27 2013, In : Journal of Biological Chemistry. 288, 39, p. 27951-27959 9 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
Spectrin
Protein Transport
Protein Binding
Proteins
20 Citations (Scopus)

Structural basis for the modulation of the neuronal Voltage-gated sodium channel Na v 1.6 by calmodulin

Chichili, V. P. R., Xiao, Y., Seetharaman, J., Cummins, T. & Sivaraman, J., 2013, In : Scientific Reports. 3, 2435.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Calmodulin
Alanine
Action Potentials
Axons
34 Citations (Scopus)

The histone code of Toxoplasma gondii comprises conserved and unique posttranslational modifications

Nardelli, S. C., Che, F. Y., Silmon de Monerri, N. C., Xiao, H., Nieves, E., Madrid-Aliste, C., Angel, S. O., Sullivan, W., Angeletti, R. H., Kim, K. & Weiss, L. M., Dec 10 2013, In : mBio. 4, 6, e00922-13.

Research output: Contribution to journalArticle

Histone Code
Toxoplasma
Post Translational Protein Processing
Histones
Epigenomics
35 Citations (Scopus)

The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration

Vanduyn, N., Settivari, R., Levora, J., Zhou, S., Unrine, J. & Nass, R., Jan 2013, In : Journal of Neurochemistry. 124, 1, p. 147-157 11 p.

Research output: Contribution to journalArticle

Nerve Degeneration
Dopaminergic Neurons
Aluminum
Neurons
Parkinson Disease
26 Citations (Scopus)

The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism

Settivari, R., VanDuyn, N., LeVora, J. & Nass, R., Sep 2013, In : NeuroToxicology. 38, p. 51-60 10 p.

Research output: Contribution to journalArticle

Nerve Degeneration
Dopaminergic Neurons
Caenorhabditis elegans
Glutathione Transferase
Neurons
15 Citations (Scopus)

The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw

Khodorova, A., Nicol, G. & Strichartz, G., Dec 19 2013, In : Neuroscience. 254, p. 312-323 12 p.

Research output: Contribution to journalArticle

Nerve Growth Factor Receptor
Hyperalgesia
Nerve Growth Factor
Sphingomyelins
Sphingomyelin Phosphodiesterase
29 Citations (Scopus)

Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain

Salvemini, D., Doyle, T., Kress, M. & Nicol, G., Feb 2013, In : Trends in Pharmacological Sciences. 34, 2, p. 110-118 9 p.

Research output: Contribution to journalArticle

Ceramides
Opiate Alkaloids
Lysosphingolipid Receptors
Pain Management
Pain
8 Citations (Scopus)

The role of TRP channels in migraine

Oxford, G. S. & Hurley, J., 2013, In : Open Pain Journal. 6, SPEC.ISSUE.1, p. 37-49 13 p.

Research output: Contribution to journalArticle

Migraine Disorders
Amino Acid Sequence Homology
Hyperalgesia
Peripheral Nervous System
Cations
24 Citations (Scopus)

The unfolded protein response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control

Joyce, B. R., Tampaki, Z., Kim, K., Wek, R. & Sullivan, W., Jul 2013, In : Eukaryotic Cell. 12, 7, p. 979-989 11 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Endoplasmic Reticulum Stress
Toxoplasma
Parasites
Eukaryotic Initiation Factor-2
40 Citations (Scopus)

Translational control in Plasmodium and Toxoplasma parasites

Zhang, M., Joyce, B. R., Sullivan, W. & Nussenzweig, V., Feb 2013, In : Eukaryotic Cell. 12, 2, p. 161-167 7 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Eukaryotic Initiation Factors
Plasmodium
Toxoplasma
Parasites
22 Citations (Scopus)

Translational regulation of RPA2 via internal ribosomal entry site and by eIF3a

Yin, J. Y., Dong, Z., Liu, R. Y., Chen, J., Liu, Z. Q. & Zhang, J-T., Jun 2013, In : Carcinogenesis. 34, 6, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

Replication Protein A
DNA Repair
DNA Damage
Post Translational Protein Processing
DNA Replication
25 Citations (Scopus)

Trimethoprim resistance of dihydrofolate reductase variants from clinical isolates of Pneumocystis jirovecii

Queener, S., Cody, V., Pace, J., Torkelson, P. & Gangjee, A., Oct 2013, In : Antimicrobial Agents and Chemotherapy. 57, 10, p. 4990-4998 9 p.

Research output: Contribution to journalArticle

Trimethoprim Resistance
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Trimethoprim
NADP
67 Citations (Scopus)

Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin

Rowe, A. H., Xiao, Y., Rowe, M. P., Cummins, T. & Zakon, H. H., 2013, In : Science. 342, 6157, p. 441-446 6 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Scorpions
Grasshoppers
Pain
Venoms
2012
46 Citations (Scopus)

Acute bacterial inflammation of the mouse prostate

Boehm, B. J., Colopy, S. A., Jerde, T., Loftus, C. J. & Bushman, W., Feb 2012, In : Prostate. 72, 3, p. 307-317 11 p.

Research output: Contribution to journalArticle

Prostate
Inflammation
Interleukin-1
Uropathogenic Escherichia coli
Hyperplasia
75 Citations (Scopus)

A Forward Genetic Screen Reveals that Calcium-dependent Protein Kinase 3 Regulates Egress in Toxoplasma

Garrison, E., Treeck, M., Ehret, E., Butz, H., Garbuz, T., Oswald, B. P., Settles, M., Boothroyd, J. & Arrizabalaga, G., Nov 2012, In : PLoS Pathogens. 8, 11, e1003049.

Research output: Contribution to journalArticle

Toxoplasma
Parasites
Ionophores
Mutation
Brain
35 Citations (Scopus)

Analysis of monensin sensitivity in toxoplasma gondii reveals autophagy as a mechanism for drug induced death

Lavine, M. D. & Arrizabalaga, G., Jul 25 2012, In : PLoS One. 7, 7, e42107.

Research output: Contribution to journalArticle

Monensin
autophagy
monensin
Autophagy
Toxoplasma
11 Citations (Scopus)

C. elegans as a genetic model system to identify Parkinson's disease- associated therapeutic targets

Vistbakka, J., VanDuyn, N., Wong, G. & Nass, R., 2012, In : CNS and Neurological Disorders - Drug Targets. 11, 8, p. 957-964 8 p.

Research output: Contribution to journalArticle

Genetic Models
Caenorhabditis elegans
Parkinson Disease
Dopaminergic Neurons
Therapeutics
103 Citations (Scopus)

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

Ashpole, N. M., Herren, A. W., Ginsburg, K. S., Brogan, J. D., Johnson, D. E., Cummins, T., Bers, D. M. & Hudmon, A., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 19856-19869 14 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Phosphorylation
Sodium Channels
Brugada Syndrome
Heart Failure
55 Citations (Scopus)
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Calcium Signaling
Glutamic Acid
Calcium
149 Citations (Scopus)

c-FLIP, a master anti-apoptotic regulator

Safa, A., Sep 2012, In : Experimental Oncology. 34, 3, p. 176-184 9 p.

Research output: Contribution to journalArticle

Apoptosis
Death Domain Receptor Signaling Adaptor Proteins
Neoplasms
Tumor Necrosis Factor-alpha
Effector Caspases
10 Citations (Scopus)

Chemosensory cue conditioning with stimulants in a Caenorhabditis elegans animal model of addiction

Musselman, H. N., Neal-Beliveau, B., Nass, R. & Engleman, E., Jun 2012, In : Behavioral Neuroscience. 126, 3, p. 445-456 12 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Cues
Animal Models
Pharmaceutical Preparations
Street Drugs
24 Citations (Scopus)

CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy

Piekarz, A. D., Due, M. R., Khanna, M., Wang, B., Ripsch, M. S., Wang, R., Meroueh, S., Vasko, M., White, F. & Khanna, R., Jul 24 2012, In : Molecular Pain. 8, 54.

Research output: Contribution to journalArticle

Nociceptors
Nociception
Peripheral Nervous System Diseases
Calcium Channels
Acquired Immunodeficiency Syndrome
9 Citations (Scopus)
Phosphorylation
Cell death
Islets of Langerhans
Cell Death
Chemical activation
21 Citations (Scopus)

Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchanger

Brittain, M. K., Brustovetsky, T., Sheets, P., Brittain, J. M., Khanna, R., Cummins, T. & Broustovetski, N., Apr 2012, In : Neurobiology of Disease. 46, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Calcium
Neurons
Memantine
Glutamic Acid
6 Citations (Scopus)

Different roles of TM5, TM6, and ECL3 in the oligomerization and function of human ABCG2

Mo, W., Qi, J. & Zhang, J-T., May 1 2012, In : Biochemistry. 51, 17, p. 3634-3641 8 p.

Research output: Contribution to journalArticle

Oligomerization
ATP-Binding Cassette Transporters
Neoplastic Stem Cells
Multiple Drug Resistance
Site-Directed Mutagenesis
15 Citations (Scopus)

Disruption of NMDAR-CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model

Brittain, J. M., Pan, R., You, H., Brustovetsky, T., Broustovetski, N., Zamponi, G. W., Lee, W. H. & Khanna, R., Jan 2012, In : Channels. 6, 1

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Rats
Human Immunodeficiency Virus Proteins
Post-Synaptic Density
Peptides
10 Citations (Scopus)

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels

Hodgdon, K. E., Hingtgen, C. M. & Nicol, G., Mar 29 2012, In : Neuroscience. 206, p. 237-244 8 p.

Research output: Contribution to journalArticle

Sodium Channels
Spinal Ganglia
Messenger RNA
Sensory Receptor Cells
Neurofibromatosis 1 Genes
17 Citations (Scopus)

Expression of sphingosine 1-phosphate receptors in the rat dorsal root ganglia and defined single isolated sensory neurons

Kays, J. S., Li, C. & Nicol, G., Sep 1 2012, In : Physiological Genomics. 44, 18, p. 889-901 13 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Spinal Ganglia
Sensory Receptor Cells
Neurons
Messenger RNA
8 Citations (Scopus)

Human ABCC1 interacts and colocalizes with ATP synthase α, revealed by interactive proteomics analysis

Yang, Y., Li, Z., Mo, W., Ambadipudi, R., Arnold, R. J., Hrncirova, P., Novotny, M. V., Georges, E. & Zhang, J-T., Feb 3 2012, In : Journal of Proteome Research. 11, 2, p. 1364-1372 9 p.

Research output: Contribution to journalArticle

Proteomics
Adenosine Triphosphate
Phosphorylation
ATP-Binding Cassette Transporters
Multiple Drug Resistance
119 Citations (Scopus)

Human ABCG2: Structure, function, and its role in multidrug resistance

Mo, W. & Zhang, J-T., 2012, In : International Journal of Biochemistry and Molecular Biology. 3, 1, p. 1-27 27 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Multiple Drug Resistance
Chemotherapy
Neoplastic Stem Cells
Endocytosis
8 Citations (Scopus)

Identification of the benzyloxyphenyl pharmacophore: A structural unit that promotes sodium channel slow inactivation

King, A. M., Yang, X. F., Wang, Y., Dustrude, E. T., Barbosa, C., Due, M. R., Piekarz, A. D., Wilson, S. M., White, F., Salomé, C., Cummins, T., Khanna, R. & Kohn, H., Dec 19 2012, In : ACS Chemical Neuroscience. 3, 12, p. 1037-1049 13 p.

Research output: Contribution to journalArticle

Electrophysiology
Stereoselectivity
Acetylation
Sodium Channels
Clamping devices
17 Citations (Scopus)

Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons

Brittain, M. K., Brustovetsky, T., Brittain, J. M., Khanna, R., Cummins, T. & Broustovetski, N., Nov 2012, In : Neuropharmacology. 63, 6, p. 974-982 9 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
N-Methylaspartate
Calcium
Neurons
Glutamate Receptors
21 Citations (Scopus)

Knockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory ganglion

Xie, W., Strong, J. A., Kays, J., Nicol, G. & Zhang, J. M., Apr 25 2012, In : Neuroscience Letters. 515, 1, p. 61-65 5 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Sensory Ganglia
Inflammation
Pain
Small Interfering RNA
63 Citations (Scopus)

Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii

Jeffers, V. & Sullivan, W., Jun 2012, In : Eukaryotic Cell. 11, 6, p. 735-742 8 p.

Research output: Contribution to journalArticle

Toxoplasma
Acetylation
Lysine
Parasites
Proteins
19 Citations (Scopus)

Mechanisms controlling neurite outgrowth in a pheochromocytoma cell line: The role of TRPC channels

Kumar, S., Chakraborty, S., Barbosa, C., Brustovetsky, T., Broustovetski, N. & Obukhov, A., Apr 2012, In : Journal of Cellular Physiology. 227, 4, p. 1408-1419 12 p.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
PC12 Cells
Nerve Growth Factor
Cells
Pheochromocytoma
108 Citations (Scopus)

Mechanisms of Toxoplasma gondii persistence and latency

Sullivan, W. & Jeffers, V., May 2012, In : FEMS Microbiology Reviews. 36, 3, p. 717-733 17 p.

Research output: Contribution to journalArticle

Toxoplasma
Parasites
Cysts
Toxoplasmosis
Immunity
17 Citations (Scopus)

Models of inflammation: Carrageenan air pouch

Duarte, D. B., Vasko, M. & Fehrenbacher, J., Mar 2012, In : Current Protocols in Pharmacology. SUPPL.56, 5.6.

Research output: Contribution to journalArticle

Carrageenan
Air
Inflammation
Irritants
Exudates and Transudates
30 Citations (Scopus)
Freund's Adjuvant
Carrageenan
Edema
Hypersensitivity
Inflammation
23 Citations (Scopus)

Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKMζ

Zhang, Y. H., Kays, J., Hodgdon, K. E., Sacktor, T. C. & Nicol, G., Jan 2012, In : Journal of Neurophysiology. 107, 1, p. 315-335 21 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Sensory Receptor Cells
Protein Isoforms
Phosphatidylinositol 3-Kinase
Small Interfering RNA
52 Citations (Scopus)

PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium

Zhang, M., Mishra, S., Sakthivel, R., Rojas, M., Ranjan, R., Sullivan, W., Fontoura, B. M. A., Ménard, R., Dever, T. E. & Nussenzweig, V., Mar 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 10, p. 3956-3961 6 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Plasmodium
Malaria
Phosphotransferases
Culicidae
13 Citations (Scopus)

Profibrotic effect of interleukin-18 in HK-2 cells is dependent on stimulation of the toll-like receptor 4 (TLR4) promoter and increased TLR4 expression

Meldrum, K. K., Zhang, H., Hile, K. L., Moldower, L. L., Dong, Z. & Meldrum, D. R., Nov 23 2012, In : Journal of Biological Chemistry. 287, 48, p. 40391-40399 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Interleukin-18
Transcription Factor AP-1
Ureteral Obstruction
Epithelial Cells
24 Citations (Scopus)

Retigeric Acid b exhibits antitumor activity through suppression of nuclear factor-κB signaling in prostate cancer cells in vitro and in vivo

Liu, Y. Q., Hu, X. Y., Lu, T., Cheng, Y. N., Young, C. Y. F., Yuan, H. Q. & Lou, H. X., May 29 2012, In : PLoS One. 7, 5, e38000.

Research output: Contribution to journalArticle

prostatic neoplasms
Prostatic Neoplasms
Cells
Acids
acids
6 Citations (Scopus)
Voltage-Gated Sodium Channels
Polyamines
Muscle
Myocardium
Modulation
11 Citations (Scopus)

Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor

Li, C., Chi, X. X., Xie, W., Strong, J. A., Zhang, J. M. & Nicol, G., Sep 1 2012, In : Journal of Neurophysiology. 108, 5, p. 1473-1483 11 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Sensory Receptor Cells
G-Protein-Coupled Receptors
Neurons
JTE 013
13 Citations (Scopus)

The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity

Song, W., Xiao, Y., Chen, H., Ashpole, N. M., Piekarz, A. D., Ma, P., Hudmon, A., Cummins, T. & Shou, W., Oct 2012, In : Journal of Physiology. 590, 20, p. 5123-5139 17 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Sodium Channels
Lidocaine
Action Potentials
Cardiac Myocytes
8 Citations (Scopus)

Toxoplasma gondii Sis1-like J-domain protein is a cytosolic chaperone associated to HSP90/HSP70 complex

Figueras, M. J., Martin, O. A., Echeverria, P. C., de Miguel, N., Naguleswaran, A., Sullivan, W., Corvi, M. M. & Angel, S. O., Apr 1 2012, In : International Journal of Biological Macromolecules. 50, 3, p. 725-733 9 p.

Research output: Contribution to journalArticle

Toxoplasma
Genes
Microarrays
Yeast
Electrostatics
16 Citations (Scopus)

Toxoplasma histone acetylation remodelers as novel drug targets

Vanagas, L., Jeffers, V., Bogado, S. S., Dalmasso, M. C., Sullivan, W. & Angel, S. O., Oct 2012, In : Expert Review of Anti-Infective Therapy. 10, 10, p. 1189-1201 13 p.

Research output: Contribution to journalArticle

Toxoplasma
Acetylation
Histones
Histone Acetyltransferases
Histone Deacetylases
2011
28 Citations (Scopus)

A GCN2-Like eukaryotic initiation factor 2 kinase increases the viability of extracellular toxoplasma gondii parasites

Konrad, C., Wek, R. & Sullivan, W., Nov 2011, In : Eukaryotic Cell. 10, 11, p. 1403-1412 10 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Toxoplasma
Parasites
Phosphotransferases
Phosphorylation