Pharmacology & Toxicology

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2013

Overexpression of asparagine synthetase and matrix metalloproteinase 19 confers cisplatin sensitivity in nasopharyngeal carcinoma cells

Liu, R. Y., Dong, Z., Liu, J., Zhou, L., Huang, W., Khoo, S. K., Zhang, Z., Petillo, D., Teh, B. T., Qian, C. N. & Zhang, J. T., Oct 1 2013, In : Molecular cancer therapeutics. 12, 10, p. 2157-2166 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Perturbations of PlasmodiumPuf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility

Lindner, S. E., Mikolajczak, S. A., Vaughan, A. M., Moon, W., Joyce, B. R., Sullivan, W. J. & Kappe, S. H. I., Jul 1 2013, In : Cellular Microbiology. 15, 7, p. 1266-1283 18 p.

Research output: Contribution to journalArticle

40 Scopus citations

PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65

Zhang, T., Ah Park, K., Li, Y., Sun Byun, H., Jeon, J., Lee, Y., Hee Hong, J., Man Kim, J., Huang, S. M., Choi, S. W., Kim, S. H., Sohn, K. C., Ro, H., Hoon Lee, J., Lu, T., Stark, G. R., Shen, H. M., Liu, Z. G., Park, J. & Min Hur, G., Jun 25 2013, In : Nature communications. 4, 2062.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

PRMT5 dimethylates R30 of the p65 subunit to activate NF-?B

Wei, H., Wang, B., Miyagi, M., She, Y., Gopalan, B., Huang, D. B., Ghosh, G., Stark, G. R. & Lu, T., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13516-13521 6 p.

Research output: Contribution to journalArticle

99 Scopus citations

Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii

Xue, B., Jeffers, V., Sullivan, W. J. & Uversky, V. N., Apr 1 2013, In : Molecular BioSystems. 9, 4, p. 645-657 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Role of lysine methylation of NF-?B in differential gene regulation

Lu, T., Yang, M., Huang, D. B., Wei, H., Ozer, G. H., Ghosh, G. & Stark, G. R., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13510-13515 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Spectrin domain of eukaryotic initiation factor 3a is the docking site for formation of the a:b:i:g subcomplex

Dong, Z., Qi, J., Peng, H., Liu, J. & Zhang, J. T., Sep 27 2013, In : Journal of Biological Chemistry. 288, 39, p. 27951-27959 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Structural basis for the modulation of the neuronal Voltage-gated sodium channel Na v 1.6 by calmodulin

Chichili, V. P. R., Xiao, Y., Seetharaman, J., Cummins, T. R. & Sivaraman, J., Aug 28 2013, In : Scientific reports. 3, 2435.

Research output: Contribution to journalArticle

23 Scopus citations

The histone code of Toxoplasma gondii comprises conserved and unique posttranslational modifications

Nardelli, S. C., Che, F. Y., Silmon de Monerri, N. C., Xiao, H., Nieves, E., Madrid-Aliste, C., Angel, S. O., Sullivan, W. J., Angeletti, R. H., Kim, K. & Weiss, L. M., Dec 10 2013, In : mBio. 4, 6, e00922-13.

Research output: Contribution to journalArticle

38 Scopus citations

The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration

Vanduyn, N., Settivari, R., Levora, J., Zhou, S., Unrine, J. & Nass, R., Jan 1 2013, In : Journal of Neurochemistry. 124, 1, p. 147-157 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism

Settivari, R., VanDuyn, N., LeVora, J. & Nass, R., Sep 1 2013, In : NeuroToxicology. 38, p. 51-60 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw

Khodorova, A., Nicol, G. D. & Strichartz, G., Dec 19 2013, In : Neuroscience. 254, p. 312-323 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

The unfolded protein response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control

Joyce, B. R., Tampaki, Z., Kim, K., Wek, R. C. & Sullivan, W. J., Jul 1 2013, In : Eukaryotic Cell. 12, 7, p. 979-989 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Translational regulation of RPA2 via internal ribosomal entry site and by eIF3a

Yin, J. Y., Dong, Z. Z., Liu, R. Y., Chen, J., Liu, Z. Q. & Zhang, J. T., Jun 1 2013, In : Carcinogenesis. 34, 6, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Trimethoprim resistance of dihydrofolate reductase variants from clinical isolates of Pneumocystis jirovecii

Queener, S. F., Cody, V., Pace, J., Torkelson, P. & Gangjee, A., Oct 1 2013, In : Antimicrobial Agents and Chemotherapy. 57, 10, p. 4990-4998 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin

Rowe, A. H., Xiao, Y., Rowe, M. P., Cummins, T. R. & Zakon, H. H., Jan 1 2013, In : Science. 342, 6157, p. 441-446 6 p.

Research output: Contribution to journalArticle

74 Scopus citations
2012

Acute bacterial inflammation of the mouse prostate

Boehm, B. J., Colopy, S. A., Jerde, T. J., Loftus, C. J. & Bushman, W., Feb 1 2012, In : Prostate. 72, 3, p. 307-317 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

A Forward Genetic Screen Reveals that Calcium-dependent Protein Kinase 3 Regulates Egress in Toxoplasma

Garrison, E., Treeck, M., Ehret, E., Butz, H., Garbuz, T., Oswald, B. P., Settles, M., Boothroyd, J. & Arrizabalaga, G., Nov 1 2012, In : PLoS pathogens. 8, 11, e1003049.

Research output: Contribution to journalArticle

77 Scopus citations

Analysis of monensin sensitivity in toxoplasma gondii reveals autophagy as a mechanism for drug induced death

Lavine, M. D. & Arrizabalaga, G., Jul 25 2012, In : PloS one. 7, 7, e42107.

Research output: Contribution to journalArticle

38 Scopus citations

C. elegans as a genetic model system to identify Parkinson's disease- associated therapeutic targets

Vistbakka, J., VanDuyn, N., Wong, G. & Nass, R., Dec 1 2012, In : CNS and Neurological Disorders - Drug Targets. 11, 8, p. 957-964 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

Ashpole, N. M., Herren, A. W., Ginsburg, K. S., Brogan, J. D., Johnson, D. E., Cummins, T. R., Bers, D. M. & Hudmon, A., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 19856-19869 14 p.

Research output: Contribution to journalArticle

108 Scopus citations
61 Scopus citations

Chemosensory cue conditioning with stimulants in a Caenorhabditis elegans animal model of addiction

Musselman, H. N., Neal-Beliveau, B., Nass, R. & Engleman, E. A., Jun 1 2012, In : Behavioral Neuroscience. 126, 3, p. 445-456 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
28 Scopus citations
9 Scopus citations

Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchanger

Brittain, M. K., Brustovetsky, T., Sheets, P. L., Brittain, J. M., Khanna, R., Cummins, T. R. & Brustovetsky, N., Apr 1 2012, In : Neurobiology of Disease. 46, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Different roles of TM5, TM6, and ECL3 in the oligomerization and function of human ABCG2

Mo, W., Qi, J. & Zhang, J. T., May 1 2012, In : Biochemistry. 51, 17, p. 3634-3641 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Disruption of NMDAR-CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model

Brittain, J. M., Pan, R., You, H., Brustovetsky, T., Brustovetsky, N., Zamponi, G. W., Lee, W. H. & Khanna, R., Jan 1 2012, In : Channels. 6, 1

Research output: Contribution to journalArticle

19 Scopus citations

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels

Hodgdon, K. E., Hingtgen, C. M. & Nicol, G. D., Mar 29 2012, In : Neuroscience. 206, p. 237-244 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Expression of sphingosine 1-phosphate receptors in the rat dorsal root ganglia and defined single isolated sensory neurons

Kays, J. S., Li, C. & Nicol, G. D., Sep 1 2012, In : Physiological Genomics. 44, 18, p. 889-901 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Human ABCC1 interacts and colocalizes with ATP synthase α, revealed by interactive proteomics analysis

Yang, Y., Li, Z., Mo, W., Ambadipudi, R., Arnold, R. J., Hrncirova, P., Novotny, M. V., Georges, E. & Zhang, J. T., Feb 3 2012, In : Journal of Proteome Research. 11, 2, p. 1364-1372 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Identification of the benzyloxyphenyl pharmacophore: A structural unit that promotes sodium channel slow inactivation

King, A. M., Yang, X. F., Wang, Y., Dustrude, E. T., Barbosa, C., Due, M. R., Piekarz, A. D., Wilson, S. M., White, F. A., Salomé, C., Cummins, T. R., Khanna, R. & Kohn, H., Dec 19 2012, In : ACS Chemical Neuroscience. 3, 12, p. 1037-1049 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons

Brittain, M. K., Brustovetsky, T., Brittain, J. M., Khanna, R., Cummins, T. R. & Brustovetsky, N., Nov 1 2012, In : Neuropharmacology. 63, 6, p. 974-982 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Knockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory ganglion

Xie, W., Strong, J. A., Kays, J., Nicol, G. D. & Zhang, J. M., Apr 25 2012, In : Neuroscience Letters. 515, 1, p. 61-65 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii

Jeffers, V. & Sullivan, W. J., Jun 1 2012, In : Eukaryotic Cell. 11, 6, p. 735-742 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

Mechanisms controlling neurite outgrowth in a pheochromocytoma cell line: The role of TRPC channels

Kumar, S., Chakraborty, S., Barbosa, C., Brustovetsky, T., Brustovetsky, N. & Obukhov, A. G., Apr 1 2012, In : Journal of cellular physiology. 227, 4, p. 1408-1419 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Models of inflammation: Carrageenan air pouch

Duarte, D. B., Vasko, M. R. & Fehrenbacher, J. C., Mar 1 2012, In : Current Protocols in Pharmacology. SUPPL.56, 5.6.

Research output: Contribution to journalArticle

20 Scopus citations
39 Scopus citations

Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKMζ

Zhang, Y. H., Kays, J., Hodgdon, K. E., Sacktor, T. C. & Nicol, G. D., Jan 1 2012, In : Journal of Neurophysiology. 107, 1, p. 315-335 21 p.

Research output: Contribution to journalArticle

24 Scopus citations

PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium

Zhang, M., Mishra, S., Sakthivel, R., Rojas, M., Ranjan, R., Sullivan, W. J., Fontoura, B. M. A., Ménard, R., Dever, T. E. & Nussenzweig, V., Mar 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 10, p. 3956-3961 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Profibrotic effect of interleukin-18 in HK-2 cells is dependent on stimulation of the toll-like receptor 4 (TLR4) promoter and increased TLR4 expression

Meldrum, K. K., Zhang, H., Hile, K. L., Moldower, L. L., Dong, Z. & Meldrum, D. R., Nov 23 2012, In : Journal of Biological Chemistry. 287, 48, p. 40391-40399 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Retigeric Acid b exhibits antitumor activity through suppression of nuclear factor-κB signaling in prostate cancer cells in vitro and in vivo

Liu, Y. Q., Hu, X. Y., Lu, T., Cheng, Y. N., Young, C. Y. F., Yuan, H. Q. & Lou, H. X., May 29 2012, In : PloS one. 7, 5, e38000.

Research output: Contribution to journalArticle

25 Scopus citations
8 Scopus citations

Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor

Li, C., Chi, X. X., Xie, W., Strong, J. A., Zhang, J. M. & Nicol, G. D., Jan 1 2012, In : Journal of Neurophysiology. 108, 5, p. 1473-1483 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity

Song, W., Xiao, Y., Chen, H., Ashpole, N. M., Piekarz, A. D., Ma, P., Hudmon, A., Cummins, T. R. & Shou, W., Oct 1 2012, In : Journal of Physiology. 590, 20, p. 5123-5139 17 p.

Research output: Contribution to journalArticle

13 Scopus citations

Toxoplasma gondii Sis1-like J-domain protein is a cytosolic chaperone associated to HSP90/HSP70 complex

Figueras, M. J., Martin, O. A., Echeverria, P. C., de Miguel, N., Naguleswaran, A., Sullivan, W. J., Corvi, M. M. & Angel, S. O., Apr 1 2012, In : International Journal of Biological Macromolecules. 50, 3, p. 725-733 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

A GCN2-Like eukaryotic initiation factor 2 kinase increases the viability of extracellular toxoplasma gondii parasites

Konrad, C., Wek, R. C. & Sullivan, W. J., Nov 1 2011, In : Eukaryotic Cell. 10, 11, p. 1403-1412 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii

Onyango, D. O., Naguleswaran, A., Delaplane, S., Reed, A., Kelley, M. R., Georgiadis, M. M. & Sullivan, W. J., May 5 2011, In : DNA Repair. 10, 5, p. 466-475 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Canonical and variant histones of protozoan parasites

Dalmasso, M. C., Sullivan, W. J. & Angel, S. O., Jun 1 2011, In : Frontiers in Bioscience. 16, 6, p. 2086-2105 20 p.

Research output: Contribution to journalArticle

15 Scopus citations