Pharmacology & Toxicology

Publications

Filter
Article
2013
10 Scopus citations

L-dopa-induced dopamine synthesis and oxidative stress in serotonergic cells

Stansley, B. J. & Yamamoto, B. K., Apr 1 2013, In : Neuropharmacology. 67, p. 243-251 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: Role of cyclooxygenase

Anneken, J. H., Cunningham, J. I., Collins, S. A., Yamamoto, B. K. & Gudelsky, G. A., Mar 1 2013, In : Journal of Neuroimmune Pharmacology. 8, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Methamphetamine causes acute hyperthermia-dependent liver damage

Halpin, L. E., Gunning, W. T. & Yamamoto, B. K., Jan 1 2013, In : Pharmacology Research and Perspectives. 1, 1, e00008.

Research output: Contribution to journalArticle

21 Scopus citations

Methylmercury exposure increases lipocalin related (lpr) and decreases activated in blocked unfolded protein response (abu) genes and specific mirnas in caenorhabditis elegans

Rudgalvyte, M., VanDuyn, N., Aarnio, V., Heikkinen, L., Peltonen, J., Lakso, M., Nass, R. & Wong, G., Oct 4 2013, In : Toxicology Letters. 222, 2, p. 189-196 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Nerve growth factor/p75 neurotrophin receptor-mediated sensitization of rat sensory neurons depends on membrane cholesterol

Zhang, Y. H., Khanna, R. & Nicol, G. D., Sep 17 2013, In : Neuroscience. 248, p. 562-570 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

NPY y 1 receptors differentially modulate gaba a and nmda receptors via divergent signal-transduction pathways to reduce excitability of amygdala neurons

Molosh, A. I., Sajdyk, T. J., Truitt, W. A., Zhu, W., Oxford, G. S. & Shekhar, A., Jun 1 2013, In : Neuropsychopharmacology. 38, 7, p. 1352-1364 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Overexpression of asparagine synthetase and matrix metalloproteinase 19 confers cisplatin sensitivity in nasopharyngeal carcinoma cells

Liu, R. Y., Dong, Z., Liu, J., Zhou, L., Huang, W., Khoo, S. K., Zhang, Z., Petillo, D., Teh, B. T., Qian, C. N. & Zhang, J. T., Oct 1 2013, In : Molecular cancer therapeutics. 12, 10, p. 2157-2166 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Perturbations of PlasmodiumPuf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility

Lindner, S. E., Mikolajczak, S. A., Vaughan, A. M., Moon, W., Joyce, B. R., Sullivan, W. J. & Kappe, S. H. I., Jul 1 2013, In : Cellular Microbiology. 15, 7, p. 1266-1283 18 p.

Research output: Contribution to journalArticle

39 Scopus citations

PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65

Zhang, T., Ah Park, K., Li, Y., Sun Byun, H., Jeon, J., Lee, Y., Hee Hong, J., Man Kim, J., Huang, S. M., Choi, S. W., Kim, S. H., Sohn, K. C., Ro, H., Hoon Lee, J., Lu, T., Stark, G. R., Shen, H. M., Liu, Z. G., Park, J. & Min Hur, G., Jun 25 2013, In : Nature communications. 4, 3062.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

PRMT5 dimethylates R30 of the p65 subunit to activate NF-?B

Wei, H., Wang, B., Miyagi, M., She, Y., Gopalan, B., Huang, D. B., Ghosh, G., Stark, G. R. & Lu, T., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13516-13521 6 p.

Research output: Contribution to journalArticle

91 Scopus citations

Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii

Xue, B., Jeffers, V., Sullivan, W. J. & Uversky, V. N., Apr 1 2013, In : Molecular BioSystems. 9, 4, p. 645-657 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Role of lysine methylation of NF-?B in differential gene regulation

Lu, T., Yang, M., Huang, D. B., Wei, H., Ozer, G. H., Ghosh, G. & Stark, G. R., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13510-13515 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Spectrin domain of eukaryotic initiation factor 3a is the docking site for formation of the a:b:i:g subcomplex

Dong, Z., Qi, J., Peng, H., Liu, J. & Zhang, J. T., Sep 27 2013, In : Journal of Biological Chemistry. 288, 39, p. 27951-27959 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Structural basis for the modulation of the neuronal Voltage-gated sodium channel Na v 1.6 by calmodulin

Chichili, V. P. R., Xiao, Y., Seetharaman, J., Cummins, T. R. & Sivaraman, J., Aug 28 2013, In : Scientific reports. 3, 2435.

Research output: Contribution to journalArticle

22 Scopus citations

The histone code of Toxoplasma gondii comprises conserved and unique posttranslational modifications

Nardelli, S. C., Che, F. Y., Silmon de Monerri, N. C., Xiao, H., Nieves, E., Madrid-Aliste, C., Angel, S. O., Sullivan, W. J., Angeletti, R. H., Kim, K. & Weiss, L. M., Dec 10 2013, In : mBio. 4, 6, e00922-13.

Research output: Contribution to journalArticle

36 Scopus citations

The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration

Vanduyn, N., Settivari, R., Levora, J., Zhou, S., Unrine, J. & Nass, R., Jan 1 2013, In : Journal of Neurochemistry. 124, 1, p. 147-157 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism

Settivari, R., VanDuyn, N., LeVora, J. & Nass, R., Sep 1 2013, In : NeuroToxicology. 38, p. 51-60 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw

Khodorova, A., Nicol, G. D. & Strichartz, G., Dec 19 2013, In : Neuroscience. 254, p. 312-323 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

The unfolded protein response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control

Joyce, B. R., Tampaki, Z., Kim, K., Wek, R. C. & Sullivan, W. J., Jul 1 2013, In : Eukaryotic Cell. 12, 7, p. 979-989 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Translational regulation of RPA2 via internal ribosomal entry site and by eIF3a

Yin, J. Y., Dong, Z. Z., Liu, R. Y., Chen, J., Liu, Z. Q. & Zhang, J. T., Jun 1 2013, In : Carcinogenesis. 34, 6, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Trimethoprim resistance of dihydrofolate reductase variants from clinical isolates of Pneumocystis jirovecii

Queener, S. F., Cody, V., Pace, J., Torkelson, P. & Gangjee, A., Oct 1 2013, In : Antimicrobial Agents and Chemotherapy. 57, 10, p. 4990-4998 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin

Rowe, A. H., Xiao, Y., Rowe, M. P., Cummins, T. R. & Zakon, H. H., Jan 1 2013, In : Science. 342, 6157, p. 441-446 6 p.

Research output: Contribution to journalArticle

69 Scopus citations
2012

Acute bacterial inflammation of the mouse prostate

Boehm, B. J., Colopy, S. A., Jerde, T. J., Loftus, C. J. & Bushman, W., Feb 1 2012, In : Prostate. 72, 3, p. 307-317 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

A Forward Genetic Screen Reveals that Calcium-dependent Protein Kinase 3 Regulates Egress in Toxoplasma

Garrison, E., Treeck, M., Ehret, E., Butz, H., Garbuz, T., Oswald, B. P., Settles, M., Boothroyd, J. & Arrizabalaga, G., Nov 1 2012, In : PLoS pathogens. 8, 11, e1003049.

Research output: Contribution to journalArticle

77 Scopus citations

Analysis of monensin sensitivity in toxoplasma gondii reveals autophagy as a mechanism for drug induced death

Lavine, M. D. & Arrizabalaga, G., Jul 25 2012, In : PLoS ONE. 7, 7, e42107.

Research output: Contribution to journalArticle

35 Scopus citations

C. elegans as a genetic model system to identify Parkinson's disease- associated therapeutic targets

Vistbakka, J., VanDuyn, N., Wong, G. & Nass, R., Dec 1 2012, In : CNS and Neurological Disorders - Drug Targets. 11, 8, p. 957-964 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

Ashpole, N. M., Herren, A. W., Ginsburg, K. S., Brogan, J. D., Johnson, D. E., Cummins, T. R., Bers, D. M. & Hudmon, A., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 19856-19869 14 p.

Research output: Contribution to journalArticle

103 Scopus citations
57 Scopus citations

Chemosensory cue conditioning with stimulants in a Caenorhabditis elegans animal model of addiction

Musselman, H. N., Neal-Beliveau, B., Nass, R. & Engleman, E. A., Jun 1 2012, In : Behavioral Neuroscience. 126, 3, p. 445-456 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
27 Scopus citations
9 Scopus citations

Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchanger

Brittain, M. K., Brustovetsky, T., Sheets, P. L., Brittain, J. M., Khanna, R., Cummins, T. R. & Brustovetsky, N., Apr 1 2012, In : Neurobiology of Disease. 46, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Different roles of TM5, TM6, and ECL3 in the oligomerization and function of human ABCG2

Mo, W., Qi, J. & Zhang, J. T., May 1 2012, In : Biochemistry. 51, 17, p. 3634-3641 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Disruption of NMDAR-CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model

Brittain, J. M., Pan, R., You, H., Brustovetsky, T., Brustovetsky, N., Zamponi, G. W., Lee, W. H. & Khanna, R., Jan 1 2012, In : Channels. 6, 1

Research output: Contribution to journalArticle

18 Scopus citations

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels

Hodgdon, K. E., Hingtgen, C. M. & Nicol, G. D., Mar 29 2012, In : Neuroscience. 206, p. 237-244 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Expression of sphingosine 1-phosphate receptors in the rat dorsal root ganglia and defined single isolated sensory neurons

Kays, J. S., Li, C. & Nicol, G. D., Sep 1 2012, In : Physiological Genomics. 44, 18, p. 889-901 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Human ABCC1 interacts and colocalizes with ATP synthase α, revealed by interactive proteomics analysis

Yang, Y., Li, Z., Mo, W., Ambadipudi, R., Arnold, R. J., Hrncirova, P., Novotny, M. V., Georges, E. & Zhang, J. T., Feb 3 2012, In : Journal of Proteome Research. 11, 2, p. 1364-1372 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Identification of the benzyloxyphenyl pharmacophore: A structural unit that promotes sodium channel slow inactivation

King, A. M., Yang, X. F., Wang, Y., Dustrude, E. T., Barbosa, C., Due, M. R., Piekarz, A. D., Wilson, S. M., White, F. A., Salomé, C., Cummins, T. R., Khanna, R. & Kohn, H., Dec 19 2012, In : ACS Chemical Neuroscience. 3, 12, p. 1037-1049 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons

Brittain, M. K., Brustovetsky, T., Brittain, J. M., Khanna, R., Cummins, T. R. & Brustovetsky, N., Nov 1 2012, In : Neuropharmacology. 63, 6, p. 974-982 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Knockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory ganglion

Xie, W., Strong, J. A., Kays, J., Nicol, G. D. & Zhang, J. M., Apr 25 2012, In : Neuroscience Letters. 515, 1, p. 61-65 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii

Jeffers, V. & Sullivan, W. J., Jun 1 2012, In : Eukaryotic Cell. 11, 6, p. 735-742 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

Mechanisms controlling neurite outgrowth in a pheochromocytoma cell line: The role of TRPC channels

Kumar, S., Chakraborty, S., Barbosa, C., Brustovetsky, T., Brustovetsky, N. & Obukhov, A. G., Apr 1 2012, In : Journal of cellular physiology. 227, 4, p. 1408-1419 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Models of inflammation: Carrageenan air pouch

Duarte, D. B., Vasko, M. R. & Fehrenbacher, J. C., Mar 1 2012, In : Current Protocols in Pharmacology. SUPPL.56, 5.6.

Research output: Contribution to journalArticle

17 Scopus citations
36 Scopus citations

Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKMζ

Zhang, Y. H., Kays, J., Hodgdon, K. E., Sacktor, T. C. & Nicol, G. D., Jan 1 2012, In : Journal of Neurophysiology. 107, 1, p. 315-335 21 p.

Research output: Contribution to journalArticle

24 Scopus citations

Peripheral ammonia as a mediator of methamphetamine neurotoxicity

Halpin, L. E. & Yamamoto, B. K., Sep 19 2012, In : Journal of Neuroscience. 32, 38, p. 13155-13163 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Persistent neuroinflammatory effects of serial exposure to stress and methamphetamine on the blood-brain barrier

Northrop, N. A. & Yamamoto, B. K., Dec 1 2012, In : Journal of Neuroimmune Pharmacology. 7, 4, p. 951-968 18 p.

Research output: Contribution to journalArticle

43 Scopus citations

PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium

Zhang, M., Mishra, S., Sakthivel, R., Rojas, M., Ranjan, R., Sullivan, W. J., Fontoura, B. M. A., Ménard, R., Dever, T. E. & Nussenzweig, V., Mar 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 10, p. 3956-3961 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Profibrotic effect of interleukin-18 in HK-2 cells is dependent on stimulation of the toll-like receptor 4 (TLR4) promoter and increased TLR4 expression

Meldrum, K. K., Zhang, H., Hile, K. L., Moldower, L. L., Dong, Z. & Meldrum, D. R., Nov 23 2012, In : Journal of Biological Chemistry. 287, 48, p. 40391-40399 9 p.

Research output: Contribution to journalArticle

14 Scopus citations