Pharmacology & Toxicology

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2011
6 Citations (Scopus)

Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii

Onyango, D. O., Naguleswaran, A., Delaplane, S., Reed, A., Kelley, M., Georgiadis, M. & Sullivan, W., May 5 2011, In : DNA Repair. 10, 5, p. 466-475 10 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Endonucleases
Toxoplasma
DNA Repair
Parasites
12 Citations (Scopus)

Canonical and variant histones of protozoan parasites

Dalmasso, M. C., Sullivan, W. & Angel, S. O., Jun 1 2011, In : Frontiers in Bioscience. 16, 6, p. 2086-2105 20 p.

Research output: Contribution to journalArticle

Histones
Parasites
Eukaryota
Epigenomics
Genes
35 Citations (Scopus)

Common molecular determinants of tarantula huwentoxin-IV inhibition of Na + channel voltage sensors in domains II and IV

Xiao, Y., Jackson, J. O., Liang, S. & Cummins, T., Aug 5 2011, In : Journal of Biological Chemistry. 286, 31, p. 27301-27310 10 p.

Research output: Contribution to journalArticle

Sodium Channels
Voltage-Gated Sodium Channels
Chemical activation
Sensors
Electric potential
11 Citations (Scopus)

Critical residue that promotes protein dimerization: A story of partially exposed Phe25 in 14-3-3σ

Liu, J. Y., Li, Z., Li, H. & Zhang, J-T., Oct 24 2011, In : Journal of Chemical Information and Modeling. 51, 10, p. 2612-2625 14 p.

Research output: Contribution to journalArticle

Oligomerization
Dimerization
Proteins
Hydrophobicity
interaction
11 Citations (Scopus)

Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase

Cody, V., Pace, J., Piraino, J. & Queener, S., Oct 2011, In : Journal of Structural Biology. 176, 1, p. 52-59 8 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Trimethoprim
Catalytic Domain
Binding Sites
Pneumocystis carinii
23 Citations (Scopus)

Differential gene expression of neonatal and adult DRG neurons correlates with the differential sensitization of TRPV1 responses to nerve growth factor

Zhu, W. & Oxford, G. S., Aug 18 2011, In : Neuroscience Letters. 500, 3, p. 192-196 5 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Nerve Growth Factor
Gene Expression
Neurons
Phosphatidylinositol 3-Kinases
15 Citations (Scopus)

Direct effects of HIV-1 tat on excitability and survival of primary dorsal root ganglion neurons: Possible contribution to HIV-1-associated pain

Chi, X., Amet, T., Byrd, D., Chang, K. H., Shah, K., Hu, N., Grantham, A., Hu, S., Duan, J., Tao, F., Nicol, G. & Yu, A., Sep 2 2011, In : PLoS One. 6, 9, e24412.

Research output: Contribution to journalArticle

Spinal Ganglia
Human immunodeficiency virus 1
Viruses
Neurons
HIV-1
11 Citations (Scopus)

DNA polymerase eta and chemotherapeutic agents

Chou, K. M., Jun 15 2011, In : Antioxidants and Redox Signaling. 14, 12, p. 2521-2529 9 p.

Research output: Contribution to journalArticle

Pyrimidine Dimers
DNA
DNA-Directed DNA Polymerase
DNA Replication
pol Genes
5 Citations (Scopus)

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C. H. A., Chen, L. T. & Chang, J. Y., Oct 1 2011, In : Cancer Letters. 309, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

DNA Repair
Drug Resistance
DNA
KB Cells
Neoplasms
25 Citations (Scopus)

Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells

Koehler, K. R., Tropel, P., Theile, J. W., Kondo, T., Cummins, T., Viville, S. & Hashino, E., Aug 10 2011, In : BMC Neuroscience. 12, 82.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Neurons
Embryoid Bodies
Cell Line
Embryonic Stem Cells
32 Citations (Scopus)

Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex

Wilson, S. M., Brittain, J. M., Piekarz, A. D., Ballard, C. J., Ripsch, M. S., Cummins, T., Hurley, J., Khanna, M., Hammes, N. M., Samuels, B. C., White, F. & Khanna, R., Sep 2011, In : Channels. 5, 5

Research output: Contribution to journalArticle

N-Type Calcium Channels
Chronic Pain
Peptides
Drug therapy
Pain
11 Citations (Scopus)

Hypertension incidence after tap-water implementation: A 13-year follow-up study in the arseniasis-endemic area of southwestern Taiwan

Wang, S. L., Li, W. F., Chen, C. J., Huang, Y. L., Chen, J. W., Chang, K. H., Tsai, L. Y. & Chou, K. M., Oct 1 2011, In : Science of the Total Environment. 409, 21, p. 4528-4535 8 p.

Research output: Contribution to journalArticle

hypertension
Arsenic
artesian well
arsenic
well water
45 Citations (Scopus)

Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide

Theile, J. W. & Cummins, T., Oct 2011, In : Molecular Pharmacology. 80, 4, p. 724-734 11 p.

Research output: Contribution to journalArticle

Riluzole
Carbamazepine
Sodium
Erythromelalgia
Peptides
17 Citations (Scopus)

Isolation and characterization of CvIV4: A pain inducing α- scorpion toxin

Rowe, A. H., Xiao, Y., Scales, J., Linse, K. D., Rowe, M. P., Cummins, T. & Zakon, H. H., Aug 24 2011, In : PLoS One. 6, 8, e23520.

Research output: Contribution to journalArticle

Scorpions
Scorpiones
Venoms
venoms
pain
35 Citations (Scopus)

KB-R7943, an inhibitor of the reverse Na +/Ca 2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex i

Brustovetsky, T., Brittain, M. K., Sheets, P., Cummins, T., Pinelis, V. & Broustovetski, N., Jan 2011, In : British Journal of Pharmacology. 162, 1, p. 255-270 16 p.

Research output: Contribution to journalArticle

Sodium-Calcium Exchanger
N-Methyl-D-Aspartate Receptors
Mitochondria
Neurons
NAD
24 Citations (Scopus)

Lidocaine reduces the transition to slow inactivation in Na v1.7 voltage-gated sodium channels

Sheets, P., Jarecki, B. W. & Cummins, T., Sep 2011, In : British Journal of Pharmacology. 164, 2 B, p. 719-730 12 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Lidocaine
Pain
Mutation
Tetrodotoxin
20 Citations (Scopus)

Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: From discovery to clinical application

Yin, J. & Zhang, J-T., Oct 2011, In : Journal of Central South University (Medical Sciences). 36, 10, p. 927-938 12 p.

Research output: Contribution to journalArticle

Disease Susceptibility
Drug Resistance
ATP-Binding Cassette Transporters
Glucuronides
Heavy Metals
57 Citations (Scopus)

Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navβ4 peptide-mediated resurgent sodium currents

Theile, J. W., Jarecki, B. W., Piekarz, A. D. & Cummins, T., Feb 2011, In : Journal of Physiology. 589, 3, p. 597-608 12 p.

Research output: Contribution to journalArticle

Erythromelalgia
Sodium
Peptides
Mutation
HEK293 Cells
58 Citations (Scopus)

Neuroprotection against traumatic brain Injury by a peptide derived from the Collapsin Response Mediator Protein 2 (CRMP2)

Brittain, J. M., Chen, L., Wilson, S. M., Brustovetsky, T., Gao, X., Ashpole, N. M., Molosh, A. I., You, H., Hudmon, A., Shekhar, A., White, F., Zamponi, G. W., Broustovetski, N., Chen, J. & Khanna, R., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37778-37792 15 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Brain
Peptides
Neurons
Human Immunodeficiency Virus Proteins
8 Citations (Scopus)

Ras signaling pathways mediate NGF-induced enhancement of excitability of small-diameter capsaicin-sensitive sensory neurons from wildtype but not Nf1+/- mice

Duan, J. H., Wang, Y., Duarte, D., Vasko, M., Nicol, G. & Hingtgen, C. M., Jun 1 2011, In : Neuroscience Letters. 496, 2, p. 70-74 5 p.

Research output: Contribution to journalArticle

Capsaicin
Nerve Growth Factor
Sensory Receptor Cells
Neurofibromatosis 1 Genes
Neurofibromin 1
70 Citations (Scopus)
Voltage-Gated Sodium Channel Blockers
Neuralgia
Sodium Channels
Pain
Sodium Channel Blockers
4 Citations (Scopus)

Reduced expression of SynGAP, a neuronal GTPase-activating protein, enhances capsaicin-induced peripheral sensitization

Duarte, D. B., Jian-Hong, D., Nicol, G., Vasko, M. & Hingtgen, C. M., Jul 2011, In : Journal of Neurophysiology. 106, 1, p. 309-318 10 p.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
Capsaicin
Calcitonin Gene-Related Peptide
Sensory Receptor Cells
Neuropeptides
14 Citations (Scopus)

Regions of intrinsic disorder help identify a novel nuclear localization signal in Toxoplasma gondii histone acetyltransferase TgGCN5-B

Dixon, S. E., Bhatti, M. M., Uversky, V. N., Dunker, A. & Sullivan, W., Feb 2011, In : Molecular and Biochemical Parasitology. 175, 2, p. 192-195 4 p.

Research output: Contribution to journalArticle

Histone Acetyltransferases
Nuclear Localization Signals
Toxoplasma
Parasites
Proteins
5 Citations (Scopus)

Regulation of phosphatase homologue of tensin protein expression by bone morphogenetic proteins in prostate epithelial cells

Jerde, T., Wu, Z., Theodorescu, D. & Bushman, W., Jun 1 2011, In : Prostate. 71, 8, p. 791-800 10 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Phosphoric Monoester Hydrolases
Prostate
Epithelial Cells
Bone Morphogenetic Protein 4
45 Citations (Scopus)

Role of eIF3a in regulating cisplatin sensitivity and in translational control of nucleotide excision repair of nasopharyngeal carcinoma

Liu, R. Y., Dong, Z., Liu, J., Yin, J. Y., Zhou, L., Wu, X., Yang, Y., Mo, W., Huang, W., Khoo, S. K., Chen, J., Petillo, D., Teh, B. T., Qian, C. N. & Zhang, J-T., Dec 1 2011, In : Oncogene. 30, 48, p. 4814-4823 10 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
DNA Repair
Cisplatin
Xeroderma Pigmentosum Group A Protein
Cell Line
47 Citations (Scopus)

Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers

Yang, Y., Liu, H., Li, Z., Zhao, Z., Yip-Schneider, M., Fan, Q., Schmidt, C., Gabriela Chiorean, E., Xie, J., Cheng, L., Chen, J. H. & Zhang, J-T., 2011, In : International Journal of Biochemistry and Molecular Biology. 2, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

gemcitabine
Fatty Acid Synthases
Pancreatic Neoplasms
Radiation
Chemotherapy
30 Citations (Scopus)

Role of interleukins, IGF and stem cells in BPH

McLaren, I. D., Jerde, T. & Bushman, W., Nov 2011, In : Differentiation. 82, 4-5, p. 237-243 7 p.

Research output: Contribution to journalArticle

Interleukins
Prostate
Stem Cells
Lower Urinary Tract Symptoms
Urinary Bladder
123 Citations (Scopus)

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

Brittain, J. M., Duarte, D. B., Wilson, S. M., Zhu, W., Ballard, C., Johnson, P., Liu, N., Xiong, W., Ripsch, M. S., Wang, Y., Fehrenbacher, J., Fitz, S. D., Khanna, M., Park, C. K., Schmutzler, B. S., Cheon, B. M., Due, M. R., Brustovetsky, T., Ashpole, N. M., Hudmon, A. & 12 others, Meroueh, S., Hingtgen, C. M., Broustovetski, N., Ji, R. R., Hurley, J., Jin, X., Shekhar, A., Xu, X-M., Oxford, G. S., Vasko, M., White, F. & Khanna, R., Jul 2011, In : Nature Medicine. 17, 7, p. 822-829 8 p.

Research output: Contribution to journalArticle

Trans-Activators
Neuralgia
Transcription
Hypersensitivity
Human Immunodeficiency Virus rev Gene Products
90 Citations (Scopus)

Targeting the anti-apoptotic protein c-FLIP for cancer therapy

Safa, A. & Pollok, K., Jun 2011, In : Cancers. 3, 2, p. 1639-1671 33 p.

Research output: Contribution to journalArticle

Apoptosis Regulatory Proteins
Apoptosis
Death Domain Receptor Signaling Adaptor Proteins
TNF-Related Apoptosis-Inducing Ligand
Neoplasms
26 Citations (Scopus)

The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation

Vasko, M., Guo, C., Thompson, E. L. & Kelley, M., Sep 5 2011, In : DNA Repair. 10, 9, p. 942-952 11 p.

Research output: Contribution to journalArticle

Ionizing radiation
Ionizing Radiation
DNA Repair
Oxidation-Reduction
Repair
29 Citations (Scopus)

Translational control gone awry: A new mechanism of tumorigenesis and novel targets of cancer treatments

Yin, J. Y., Dong, Z., Liu, Z. Q. & Zhang, J-T., Feb 2011, In : Bioscience Reports. 31, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

Oncology
Carcinogenesis
Gene Expression Regulation
Gene expression regulation
Eukaryotic Initiation Factors
10 Citations (Scopus)

Translation control is critical during acute and chronic stages of toxoplasmosis infection

Joyce, B. R., Konrad, C., Wek, R. & Sullivan, W., Jan 2011, In : Expert Review of Anti-Infective Therapy. 9, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Apicomplexa
Heat-Shock Response
Toxoplasmosis
Toxoplasma
84 Citations (Scopus)

TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation

Kunkler, P. E., Ballard, C. J., Oxford, G. S. & Hurley, J., Jan 2011, In : Pain. 152, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

Irritants
Vasodilation
Neurogenic Inflammation
Headache
Mustard Compounds
16 Citations (Scopus)

Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by paclitaxel

Gracias, N. G., Cummins, T., Kelley, M., Basile, D., Iqbal, T. & Vasko, M., Jan 2011, In : NeuroToxicology. 32, 1, p. 140-149 10 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Paclitaxel
Vasodilation
Neurons
Rats
2010
37 Citations (Scopus)
Folic Acid Antagonists
Pyrimidines
Tetrahydrofolate Dehydrogenase
Thymidylate Synthase
Pathogens
17 Citations (Scopus)

4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Huang, S., Murphy, M. & Safa, A., Sep 2010, In : Molecular and Cellular Biochemistry. 342, 1-2, p. 133-142 10 p.

Research output: Contribution to journalArticle

Caspase 10
Cells
Apoptosis
Breast Neoplasms
Messenger RNA
39 Citations (Scopus)

A decade of epigenetic research in Toxoplasma gondii

Dixon, S. E., Stilger, K. L., Elias, E. V., Naguleswaran, A. & Sullivan, W., Sep 2010, In : Molecular and Biochemical Parasitology. 173, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Parasitology
Explosions
Toxoplasma
Eukaryota
Epigenomics
14 Citations (Scopus)

Augmented sodium currents contribute to the enhanced excitability of small diameter capsaicin-sensitive sensory neurons isolated from Nf1+/- mice

Wang, Y., Duan, J. H., Hingtgen, C. M. & Nicol, G., Apr 2010, In : Journal of Neurophysiology. 103, 4, p. 2085-2094 10 p.

Research output: Contribution to journalArticle

Capsaicin
Sensory Receptor Cells
Sodium
Neurons
Neurofibromatosis 1 Genes
23 Citations (Scopus)

BAX insertion, oligomerization, and outer membrane permeabilization in brain mitochondria: Role of permeability transition and SH-redox regulation

Brustovetsky, T., Li, T., Yang, Y., Zhang, J-T., Antonsson, B. & Broustovetski, N., Nov 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 11, p. 1795-1806 12 p.

Research output: Contribution to journalArticle

Oligomerization
Mitochondria
Mitochondrial Membranes
Oxidation-Reduction
Permeability
79 Citations (Scopus)
Fatty Acid Synthases
Biochemistry
Molecular biology
Molecular Biology
Pharmacology
29 Citations (Scopus)
Calpain
Glutamic Acid
Calcium
Neurons
Protein Isoforms
6 Citations (Scopus)
Folic Acid Antagonists
Salts
Toxoplasmosis
Solubility
Enzymes
23 Citations (Scopus)

Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens

Bag, S., Tawari, N. R., Degani, M. S. & Queener, S., May 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 9, p. 3187-3197 11 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Pathogens
Pneumocystis carinii
Mycobacterium avium
10 Citations (Scopus)

Dissimilar mechanisms of cytochrome c release induced by octyl glucoside-activated BAX and by BAX activated with truncated BID

Li, T., Brustovetsky, T., Antonsson, B. & Broustovetski, N., Jan 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 1, p. 52-62 11 p.

Research output: Contribution to journalArticle

Cytochromes c
Mitochondria
Depolarization
Mitochondrial Membranes
Membranes
9 Citations (Scopus)

Diversifying biomedical training: A synergistic intervention

Gibau, G. S., Foertsch, J., Blum, J., Brutkiewicz, R., Queener, S., Roman, A., Rhodes, S., Sturek, M., Wilkes, D. & Broxmeyer, H., 2010, In : Journal of Women and Minorities in Science and Engineering. 16, 3, p. 215-235 21 p.

Research output: Contribution to journalArticle

minority
Students
grant
Pipelines
program diversity
28 Citations (Scopus)

Dynamic vs static ABCG2 inhibitors to sensitize drug resistant cancer cells

Peng, H., Qi, J., Dong, Z. & Zhang, J-T., 2010, In : PLoS One. 5, 12, e15276.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Corrosion inhibitors
Cells
Degradation
drugs
19 Citations (Scopus)

Effects of low-level light therapy on streptozotocin-induced diabetic kidney

Lim, J., Sanders, R. A., Snyder, A. C., Eells, J. T., Henshel, D. S. & Watkins, J. B., May 2010, In : Journal of Photochemistry and Photobiology B: Biology. 99, 2, p. 105-110 6 p.

Research output: Contribution to journalArticle

kidneys
Streptozocin
therapy
Kidney
rats
63 Citations (Scopus)

Global microRNA expression profiling of caenorhabditis elegans Parkinson's disease models

Asikainen, S., Rudgalvyte, M., Heikkinen, L., Louhiranta, K., Lakso, M., Wong, G. & Nass, R., May 2010, In : Journal of Molecular Neuroscience. 41, 1, p. 210-218 9 p.

Research output: Contribution to journalArticle

Synucleins
Caenorhabditis elegans
MicroRNAs
Parkinson Disease
Cats
87 Citations (Scopus)

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

Jarecki, B. W., Piekarz, A. D., Jackson, J. O. & Cummins, T., Jan 4 2010, In : Journal of Clinical Investigation. 120, 1, p. 369-378 10 p.

Research output: Contribution to journalArticle

Channelopathies
Voltage-Gated Sodium Channels
Sodium
Muscles
Mutation
21 Citations (Scopus)

Identification of novel small molecule inhibitors of the XPA protein using in silico based screening

Neher, T. M., Shuck, S. C., Liu, J. Y., Zhang, J-T. & Turchi, J., Oct 15 2010, In : ACS Chemical Biology. 5, 10, p. 953-965 13 p.

Research output: Contribution to journalArticle

Xeroderma Pigmentosum Group A Protein
Computer Simulation
Screening
Molecules
DNA