Pharmacology & Toxicology

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2011

Common molecular determinants of tarantula huwentoxin-IV inhibition of Na + channel voltage sensors in domains II and IV

Xiao, Y., Jackson, J. O., Liang, S. & Cummins, T. R., Aug 5 2011, In : Journal of Biological Chemistry. 286, 31, p. 27301-27310 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Corticospinal-specific HCN expression in mouse motor cortex: I h)-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control

Sheets, P. L., Suter, B. A., Kiritani, T., Savio Chan, C. S., James Surmeier, D. & Shepherd, G. M. G., Nov 2011, In : Journal of Neurophysiology. 106, 5, p. 2216-2231 16 p.

Research output: Contribution to journalArticle

72 Scopus citations

Critical residue that promotes protein dimerization: A story of partially exposed Phe25 in 14-3-3σ

Liu, J. Y., Li, Z., Li, H. & Zhang, J. T., Oct 24 2011, In : Journal of Chemical Information and Modeling. 51, 10, p. 2612-2625 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase

Cody, V., Pace, J., Piraino, J. & Queener, S. F., Oct 1 2011, In : Journal of Structural Biology. 176, 1, p. 52-59 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Differential gene expression of neonatal and adult DRG neurons correlates with the differential sensitization of TRPV1 responses to nerve growth factor

Zhu, W. & Oxford, G. S., Aug 18 2011, In : Neuroscience Letters. 500, 3, p. 192-196 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Direct effects of HIV-1 tat on excitability and survival of primary dorsal root ganglion neurons: Possible contribution to HIV-1-associated pain

Chi, X., Amet, T., Byrd, D., Chang, K. H., Shah, K., Hu, N., Grantham, A., Hu, S., Duan, J., Tao, F., Nicol, G. & Yu, Q., Sep 2 2011, In : PloS one. 6, 9, e24412.

Research output: Contribution to journalArticle

16 Scopus citations

DNA lesion bypass polymerases and 4'-thio-β-D-arabinofuranosylcytosine (T-arac)

Chen, Y. W. & Chou, K. M., Dec 1 2011, In : International Journal of Biochemistry and Molecular Biology. 2, 4, p. 340-346 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effect of eIF3a on response of lung cancer patients to platinum-based chemotherapy by regulating DNA repair

Yin, J. Y., Shen, J., Dong, Z. Z., Huang, Q., Zhong, M. Z., Feng, D. Y., Zhou, H. H., Zhang, J. T. & Liu, Z. Q., Jul 1 2011, In : Clinical Cancer Research. 17, 13, p. 4600-4609 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C. H. A., Chen, L. T. & Chang, J. Y., Oct 1 2011, In : Cancer Letters. 309, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells

Koehler, K. R., Tropel, P., Theile, J. W., Kondo, T., Cummins, T. R., Viville, S. & Hashino, E., Aug 10 2011, In : BMC Neuroscience. 12, 82.

Research output: Contribution to journalArticle

27 Scopus citations

Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex

Wilson, S. M., Brittain, J. M., Piekarz, A. D., Ballard, C. J., Ripsch, M. S., Cummins, T. R., Hurley, J. H., Khanna, M., Hammes, N. M., Samuels, B. C., White, F. A. & Khanna, R., Jan 1 2011, In : Channels. 5, 5

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Hypertension incidence after tap-water implementation: A 13-year follow-up study in the arseniasis-endemic area of southwestern Taiwan

Wang, S. L., Li, W. F., Chen, C. J., Huang, Y. L., Chen, J. W., Chang, K. H., Tsai, L. Y. & Chou, K. M., Oct 1 2011, In : Science of the Total Environment. 409, 21, p. 4528-4535 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide

Theile, J. W. & Cummins, T. R., Oct 1 2011, In : Molecular Pharmacology. 80, 4, p. 724-734 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Isolation and characterization of CvIV4: A pain inducing α- scorpion toxin

Rowe, A. H., Xiao, Y., Scales, J., Linse, K. D., Rowe, M. P., Cummins, T. R. & Zakon, H. H., Aug 24 2011, In : PLoS ONE. 6, 8, e23520.

Research output: Contribution to journalArticle

18 Scopus citations

KB-R7943, an inhibitor of the reverse Na +/Ca 2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex i

Brustovetsky, T., Brittain, M. K., Sheets, P. L., Cummins, T. R., Pinelis, V. & Brustovetsky, N., Jan 1 2011, In : British Journal of Pharmacology. 162, 1, p. 255-270 16 p.

Research output: Contribution to journalArticle

39 Scopus citations

Lidocaine reduces the transition to slow inactivation in Na v1.7 voltage-gated sodium channels

Sheets, P. L., Jarecki, B. W. & Cummins, T. R., Sep 1 2011, In : British Journal of Pharmacology. 164, 2 B, p. 719-730 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navβ4 peptide-mediated resurgent sodium currents

Theile, J. W., Jarecki, B. W., Piekarz, A. D. & Cummins, T. R., Feb 1 2011, In : Journal of Physiology. 589, 3, p. 597-608 12 p.

Research output: Contribution to journalArticle

60 Scopus citations

Neuroprotection against traumatic brain Injury by a peptide derived from the Collapsin Response Mediator Protein 2 (CRMP2)

Brittain, J. M., Chen, L., Wilson, S. M., Brustovetsky, T., Gao, X., Ashpole, N. M., Molosh, A. I., You, H., Hudmon, A., Shekhar, A., White, F. A., Zamponi, G. W., Brustovetsky, N., Chen, J. & Khanna, R., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37778-37792 15 p.

Research output: Contribution to journalArticle

62 Scopus citations
8 Scopus citations
74 Scopus citations

Reduced expression of SynGAP, a neuronal GTPase-activating protein, enhances capsaicin-induced peripheral sensitization

Duarte, D. B., Jian-Hong, D., Nicol, G. D., Vasko, M. R. & Hingtgen, C. M., Jul 1 2011, In : Journal of Neurophysiology. 106, 1, p. 309-318 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Regions of intrinsic disorder help identify a novel nuclear localization signal in Toxoplasma gondii histone acetyltransferase TgGCN5-B

Dixon, S. E., Bhatti, M. M., Uversky, V. N., Dunker, A. K. & Sullivan, W. J., Feb 1 2011, In : Molecular and Biochemical Parasitology. 175, 2, p. 192-195 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regulation of phosphatase homologue of tensin protein expression by bone morphogenetic proteins in prostate epithelial cells

Jerde, T. J., Wu, Z., Theodorescu, D. & Bushman, W., Jun 1 2011, In : Prostate. 71, 8, p. 791-800 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Role of eIF3a in regulating cisplatin sensitivity and in translational control of nucleotide excision repair of nasopharyngeal carcinoma

Liu, R. Y., Dong, Z., Liu, J., Yin, J. Y., Zhou, L., Wu, X., Yang, Y., Mo, W., Huang, W., Khoo, S. K., Chen, J., Petillo, D., Teh, B. T., Qian, C. N. & Zhang, J. T., Dec 1 2011, In : Oncogene. 30, 48, p. 4814-4823 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers

Yang, Y., Liu, H., Li, Z., Zhao, Z., Yip-Schneider, M., Fan, Q., Max Schmidt, C., Gabriela Chiorean, E., Xie, J., Cheng, L., Chen, J. H. & Zhang, J. T., Mar 7 2011, In : International Journal of Biochemistry and Molecular Biology. 2, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

Brittain, J. M., Duarte, D. B., Wilson, S. M., Zhu, W., Ballard, C., Johnson, P. L., Liu, N., Xiong, W., Ripsch, M. S., Wang, Y., Fehrenbacher, J. C., Fitz, S. D., Khanna, M., Park, C. K., Schmutzler, B. S., Cheon, B. M., Due, M. R., Brustovetsky, T., Ashpole, N. M., Hudmon, A. & 12 others, Meroueh, S. O., Hingtgen, C. M., Brustovetsky, N., Ji, R. R., Hurley, J. H., Jin, X., Shekhar, A., Xu, X. M., Oxford, G. S., Vasko, M. R., White, F. A. & Khanna, R., Jul 1 2011, In : Nature Medicine. 17, 7, p. 822-829 8 p.

Research output: Contribution to journalArticle

140 Scopus citations

The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation

Vasko, M. R., Guo, C., Thompson, E. L. & Kelley, M. R., Sep 5 2011, In : DNA Repair. 10, 9, p. 942-952 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation

Kunkler, P. E., Ballard, C. J., Oxford, G. S. & Hurley, J. H., Jan 1 2011, In : Pain. 152, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

87 Scopus citations

Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by paclitaxel

Gracias, N. G., Cummins, T. R., Kelley, M. R., Basile, D. P., Iqbal, T. & Vasko, M. R., Jan 1 2011, In : NeuroToxicology. 32, 1, p. 140-149 10 p.

Research output: Contribution to journalArticle

18 Scopus citations
2010
37 Scopus citations

4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Huang, S., Murphy, M. P. & Safa, A. R., Sep 1 2010, In : Molecular and Cellular Biochemistry. 342, 1-2, p. 133-142 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Augmented sodium currents contribute to the enhanced excitability of small diameter capsaicin-sensitive sensory neurons isolated from Nf1+/- mice

Wang, Y., Duan, J. H., Hingtgen, C. M. & Nicol, G. D., Apr 2010, In : Journal of Neurophysiology. 103, 4, p. 2085-2094 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

BAX insertion, oligomerization, and outer membrane permeabilization in brain mitochondria: Role of permeability transition and SH-redox regulation

Brustovetsky, T., Li, T., Yang, Y., Zhang, J. T., Antonsson, B. & Brustovetsky, N., Nov 1 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 11, p. 1795-1806 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
31 Scopus citations
6 Scopus citations

Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens

Bag, S., Tawari, N. R., Degani, M. S. & Queener, S. F., May 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 9, p. 3187-3197 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Dissimilar mechanisms of cytochrome c release induced by octyl glucoside-activated BAX and by BAX activated with truncated BID

Li, T., Brustovetsky, T., Antonsson, B. & Brustovetsky, N., Jan 1 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 1, p. 52-62 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Diversifying biomedical training: A synergistic intervention

Gibau, G. S., Foertsch, J., Blum, J., Brutkiewicz, R., Queener, S., Roman, A., Rhodes, S., Sturek, M., Wilkes, D. & Broxmeyer, H., 2010, In : Journal of Women and Minorities in Science and Engineering. 16, 3, p. 215-235 21 p.

Research output: Contribution to journalArticle

10 Scopus citations

Dynamic vs static ABCG2 inhibitors to sensitize drug resistant cancer cells

Peng, H., Qi, J., Dong, Z. & Zhang, J. T., Dec 20 2010, In : PloS one. 5, 12, e15276.

Research output: Contribution to journalArticle

29 Scopus citations

Effects of low-level light therapy on streptozotocin-induced diabetic kidney

Lim, J., Sanders, R. A., Snyder, A. C., Eells, J. T., Henshel, D. S. & Watkins, J. B., May 1 2010, In : Journal of Photochemistry and Photobiology B: Biology. 99, 2, p. 105-110 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Global microRNA expression profiling of caenorhabditis elegans Parkinson's disease models

Asikainen, S., Rudgalvyte, M., Heikkinen, L., Louhiranta, K., Lakso, M., Wong, G. & Nass, R., May 1 2010, In : Journal of Molecular Neuroscience. 41, 1, p. 210-218 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

Jarecki, B. W., Piekarz, A. D., Jackson, J. O. & Cummins, T. R., Jan 4 2010, In : Journal of Clinical Investigation. 120, 1, p. 369-378 10 p.

Research output: Contribution to journalArticle

93 Scopus citations

Identification of novel small molecule inhibitors of the XPA protein using in silico based screening

Neher, T. M., Shuck, S. C., Liu, J. Y., Zhang, J. T. & Turchi, J. J., Oct 15 2010, In : ACS chemical biology. 5, 10, p. 953-965 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

In Silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation

Wang, Y., Brittain, J. M., Jarecki, B. W., Park, K. D., Wilson, S. M., Wang, B., Hale, R., Meroueh, S. O., Cummins, T. R. & Khanna, R., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25296-25307 12 p.

Research output: Contribution to journalArticle

61 Scopus citations

Interaction between DNA polymerase λ and anticancer nucleoside analogs

Garcia-Diaz, M., Murray, M. S., Kunkel, T. A. & Chou, K. M., May 28 2010, In : Journal of Biological Chemistry. 285, 22, p. 16874-16879 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

MYST family lysine acetyltransferase facilitates Ataxia Telangiectasia Mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii

Vonlaufen, N., Naguleswaran, A., Coppens, I. & Sullivan, W. J., Apr 9 2010, In : Journal of Biological Chemistry. 285, 15, p. 11154-11161 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Neuroprotective effect of KB-r7943 against glutamate excitotoxicity is related to mild mitochondrial depolarization

Storozhevykh, T. P., Senilova, Y. E., Brustovetsky, T., Pinelis, V. G. & Brustovetsky, N., Feb 1 2010, In : Neurochemical Research. 35, 2, p. 323-335 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
48 Scopus citations

Regulation of NF-κB by NSD1/FBXL11-dependent reversible lysine methylation of p65

Lu, T., Jackson, M. W., Wang, B., Yang, M., Chance, M. R., Miyagi, M., Gudkov, A. V. & Stark, G. R., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle

170 Scopus citations

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

Yang, J., Huang, J., Dasgupta, M., Sears, N., Miyagi, M., Wang, B., Chance, M. R., Chen, X., Du, Y., Wang, Y., An, L., Wang, Q., Lu, T., Zhang, X., Wang, Z. & Stark, G. R., Dec 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21499-21504 6 p.

Research output: Contribution to journalArticle

171 Scopus citations