Pharmacology & Toxicology

Publications 1971 2020

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2010
58 Citations (Scopus)

In Silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation

Wang, Y., Brittain, J. M., Jarecki, B. W., Park, K. D., Wilson, S. M., Wang, B., Hale, R., Meroueh, S., Cummins, T. & Khanna, R., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25296-25307 12 p.

Research output: Contribution to journalArticle

Sodium Channels
Computer Simulation
Binding Sites
Voltage-Gated Sodium Channels
Alanine
11 Citations (Scopus)

Interaction between DNA polymerase λ and anticancer nucleoside analogs

Garcia-Diaz, M., Murray, M. S., Kunkel, T. A. & Chou, K. M., May 28 2010, In : Journal of Biological Chemistry. 285, 22, p. 16874-16879 6 p.

Research output: Contribution to journalArticle

Cytarabine
DNA-Directed DNA Polymerase
Nucleosides
gemcitabine
Conformations
21 Citations (Scopus)

MYST family lysine acetyltransferase facilitates Ataxia Telangiectasia Mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii

Vonlaufen, N., Naguleswaran, A., Coppens, I. & Sullivan, W., Apr 9 2010, In : Journal of Biological Chemistry. 285, 15, p. 11154-11161 8 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Acetyltransferases
Toxoplasma
Lysine
DNA Damage
9 Citations (Scopus)

Neuroprotective effect of KB-r7943 against glutamate excitotoxicity is related to mild mitochondrial depolarization

Storozhevykh, T. P., Senilova, Y. E., Brustovetsky, T., Pinelis, V. G. & Broustovetski, N., Feb 2010, In : Neurochemical Research. 35, 2, p. 323-335 13 p.

Research output: Contribution to journalArticle

Depolarization
Neuroprotective Agents
Glutamic Acid
Kainic Acid
Neurons
48 Citations (Scopus)
Eukaryotic Initiation Factor-2
Toxoplasma
Parasites
Phosphorylation
Toxoplasmosis
28 Citations (Scopus)

Role of 14-3-3σ in poor prognosis and in radiation and drug resistance of human pancreatic cancers

Li, Z., Dong, Z., Myer, D., Yip-Schneider, M., Liu, J., Cui, P., Schmidt, C. & Zhang, J-T., Nov 1 2010, In : BMC Cancer. 10, 598.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Drug Resistance
Radiation
14-3-3 Proteins
Apoptosis
13 Citations (Scopus)

Role of transmembrane segment 5 and extracellular loop 3 in the homodimerization of human ABCC1

Yang, Y., Mo, W. & Zhang, J-T., Dec 28 2010, In : Biochemistry. 49, 51, p. 10854-10861 8 p.

Research output: Contribution to journalArticle

Dimerization
ATP-Binding Cassette Transporters
Membrane Transport Proteins
Multiple Drug Resistance
Hydrophobicity
16 Citations (Scopus)
Bearings (structural)
TNF-Related Apoptosis-Inducing Ligand Receptors
P-Glycoprotein
Leukemia
Apoptosis
17 Citations (Scopus)

Signaling pathways that mediate nerve growth factor-induced increase in expression and release of calcitonin gene-related peptide from sensory neurons

Park, K. A., Fehrenbacher, J., Thompson, E. L., Duarte, D. B., Hingtgen, C. M. & Vasko, M., Dec 15 2010, In : Neuroscience. 171, 3, p. 910-923 14 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
Nerve Growth Factor
Sensory Receptor Cells
Capsaicin
Farnesyltranstransferase
61 Citations (Scopus)

SKN-1/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity

VanDuyn, N., Settivari, R., Wong, G. & Nass, R., Dec 2010, In : Toxicological Sciences. 118, 2, p. 613-624 12 p., kfq285.

Research output: Contribution to journalArticle

Nerve Degeneration
Dopaminergic Neurons
Caenorhabditis elegans
Neurons
Toxicity
381 Citations (Scopus)

Sodium channels in normal and pathological pain

Dib-Hajj, S. D., Cummins, T., Black, J. A. & Waxman, S. G., 2010, In : Annual Review of Neuroscience. 33, p. 325-347 23 p.

Research output: Contribution to journalArticle

Sodium Channels
Pain
Voltage-Gated Sodium Channels
Nervous System Trauma
Somatoform Disorders
12 Citations (Scopus)
Trimetrexate
Biguanides
Folic Acid Antagonists
Pneumocystis carinii
Mycobacterium avium
11 Citations (Scopus)

The deorphanization of TRPV1 and the emergence of octadecadienoids as a new class of lipid transmitters

Flores, C. M. & Vasko, M., Jun 2010, In : Molecular Interventions. 10, 3, p. 137-140 4 p.

Research output: Contribution to journalArticle

Lipids
Pain
Nociceptors
Eicosanoids
Capsaicin

The launch of international journal of biochemistry and molecular biology

Zhang, J-T., Turchi, J., Kumar, R., Hong, W., Shaw, G. & Wang, D., 2010, In : International Journal of Biochemistry and Molecular Biology. 1, 1, p. 1 1 p.

Research output: Contribution to journalArticle

Biochemistry
Molecular biology
78 Citations (Scopus)

The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands

Zhang, M., Fennell, C., Ranford-Cartwright, L., Sakthivel, R., Gueirard, P., Meister, S., Caspi, A., Doerig, C., Nussenzweig, R. S., Tuteja, R., Sullivan, W., Roos, D. S., Fontoura, B. M. A., Ménard, R., Winzeler, E. A. & Nussenzweig, V., Jul 5 2010, In : Journal of Experimental Medicine. 207, 7, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Sporozoites
Plasmodium
Salivary Glands
Culicidae
35 Citations (Scopus)
Lysosphingolipid Receptors
Sensory Receptor Cells
Neurons
Small Interfering RNA
Messenger RNA
72 Citations (Scopus)

The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation

Xiao, Y., Blumenthal, K., Jackson, J. O., Liang, S. & Cummins, T., Dec 2010, In : Molecular Pharmacology. 78, 6, p. 1124-1134 11 p.

Research output: Contribution to journalArticle

Sodium Channels
Inhibitory Concentration 50
Mutation
NAV1.7 Voltage-Gated Sodium Channel
Spider Venoms
24 Citations (Scopus)

Toxoplasma gondii lysine acetyltransferase GCN5-a functions in the cellular response to alkaline stress and expression of cyst genes

Naguleswaran, A., Elias, E. V., McClintick, J., Edenberg, H. & Sullivan, W., 2010, In : PLoS Pathogens. 6, 12, e1001232.

Research output: Contribution to journalArticle

Toxoplasma
Cysts
Gene Expression
Genes
Genome
2009
41 Citations (Scopus)

14-3-3σ, the double-edged sword of human cancers

Li, Z., Liu, J. Y. & Zhang, J-T., 2009, In : American Journal of Translational Research. 1, 4, p. 326-340 15 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
Molecular Chaperones
DNA
Antineoplastic Agents
Tumors
16 Citations (Scopus)

Alternative splicing of NaV1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T

Jarecki, B. W., Sheets, P., Xiao, Y., Jackson, J. O. & Cummins, T., Jul 2009, In : Channels. 3, 4

Research output: Contribution to journalArticle

Alternative Splicing
Architectural Accessibility
Exons
Erythromelalgia
Chemical activation
127 Citations (Scopus)

An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels

Brittain, J. M., Piekarz, A. D., Wang, Y., Kondo, T., Cummins, T. & Khanna, R., Nov 6 2009, In : Journal of Biological Chemistry. 284, 45, p. 31375-31390 16 p.

Research output: Contribution to journalArticle

Calcium Channels
Neurons
Neurotransmitter Agents
Electric potential
Proteins
37 Citations (Scopus)

A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapy

Peng, H., Dong, Z., Qi, J., Yang, Y., Liu, Y., Li, Z., Xu, J. & Zhang, J-T., May 24 2009, In : PLoS One. 4, 5, e5676.

Research output: Contribution to journalArticle

Chemotherapy
multiple drug resistance
Multiple Drug Resistance
Stem cells
drug therapy
13 Citations (Scopus)

C-FLIP gene silencing eliminates tumor cells in breast cancer xenografts without affecting stromal cells

Day, T. W., Sinn, A. L., Huang, S., Pollok, K., Sandusky, G. & Safa, A., Oct 2009, In : Anticancer Research. 29, 10, p. 3883-3886 4 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Gene Silencing
Stromal Cells
Heterografts
Breast Neoplasms
44 Citations (Scopus)

Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population

Yin, J. Y., Huang, Q., Yang, Y., Zhang, J-T., Zhong, M. Z., Zhou, H. H. & Liu, Z. Q., Mar 2009, In : Pharmacogenetics and Genomics. 19, 3, p. 206-216 11 p.

Research output: Contribution to journalArticle

Mutation
Single Nucleotide Polymorphism
CHO Cells
Population
Etoposide
16 Citations (Scopus)

Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes

Cody, V., Pace, J., Makin, J., Piraino, J., Queener, S. & Rosowsky, A., Mar 3 2009, In : Biochemistry. 48, 8, p. 1702-1711 10 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Mutant Proteins
Catalytic Domain
Kinetics
29 Citations (Scopus)

Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors

Gangjee, A., Li, W., Lin, L., Zeng, Y., Ihnat, M., Warnke, L. A., Green, D. W., Cody, V., Pace, J. & Queener, S., Oct 15 2009, In : Bioorganic and Medicinal Chemistry. 17, 20, p. 7324-7336 13 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pyrimidines
Tetrahydrofolate Dehydrogenase
Protein-Tyrosine Kinases
Crystal structure
28 Citations (Scopus)

Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells

Shen, F., Bailey, B. J., Chu, S., Bence, A. K., Xue, X., Erickson, P., Safa, A., Beck, W. T. & Erickson, L. C., Aug 2009, In : Journal of Pharmacology and Experimental Therapeutics. 330, 2, p. 423-429 7 p.

Research output: Contribution to journalArticle

Mitoxantrone
Multiple Drug Resistance
P-Glycoprotein
Neoplasms
valspodar
15 Citations (Scopus)

Early and Late Contributions of Glutamate and CGRP to Mechanical Sensitization by Endothelin-1

Khodorova, A., Richter, J., Vasko, M. & Strichartz, G., Jul 2009, In : Journal of Pain. 10, 7, p. 740-749 10 p.

Research output: Contribution to journalArticle

Endothelin-1
Glutamic Acid
Hyperalgesia
Capsaicin
Injections
22 Citations (Scopus)

Effects of low-level light therapy on hepatic antioxidant defense in acute and chronic diabetic rats

Lim, J., Ali, Z. M., Sanders, R. A., Snyder, A. C., Eells, J. T., Henshel, D. S. & Watkins, J. B., Jan 2009, In : Journal of Biochemical and Molecular Toxicology. 23, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Oxidative stress
Rats
Antioxidants
Oxidative Stress
Medical problems
23 Citations (Scopus)

Etoposide induces protein kinase Cδ- and caspase-3-dependent apoptosis in neuroblastoma cancer cells

Day, T. W., Wu, C. H. & Safa, A., Sep 2009, In : Molecular Pharmacology. 76, 3, p. 632-640 9 p.

Research output: Contribution to journalArticle

Etoposide
Neuroblastoma
Caspase 3
Protein Kinase C
Caspase 8
17 Citations (Scopus)
beta-galactoside alpha-2,3-sialyltransferase
Sialyltransferases
Galactosides
Caspase 8
Paclitaxel
4 Citations (Scopus)

Local anesthetics: A new hydrophilic pathway for the drug-receptor reaction

Butterworth, J. & Oxford, G. S., Jul 2009, In : Anesthesiology. 111, 1, p. 12-14 3 p.

Research output: Contribution to journalArticle

Drug Receptors
Local Anesthetics
9 Citations (Scopus)

Local Antinociception Induced by Endothelin-1 in the Hairy Skin of the Rat's Back

Shrestha, S., Gracias, N. G., Mujenda, F., Khodorova, A., Vasko, M. & Strichartz, G. R., Jul 2009, In : Journal of Pain. 10, 7, p. 702-714 13 p.

Research output: Contribution to journalArticle

Endothelin-1
Skin
Nimodipine
Subcutaneous Injections
Epinephrine
15 Citations (Scopus)

Oligomerization of human ATP-binding cassette transporters and its potential significance in human disease

Mo, W. & Zhang, J-T., Sep 2009, In : Expert Opinion on Drug Metabolism and Toxicology. 5, 9, p. 1049-1063 15 p.

Research output: Contribution to journalArticle

Oligomerization
ATP-Binding Cassette Transporters
Chemotherapy
Multiple Drug Resistance
Pharmaceutical Preparations
162 Citations (Scopus)

Peripheral mechanisms of pain and analgesia

Stein, C., Clark, J. D., Oh, U., Vasko, M., Wilcox, G. L., Overland, A. C., Vanderah, T. W. & Spencer, R. H., Apr 2009, In : Brain Research Reviews. 60, 1, p. 90-113 24 p.

Research output: Contribution to journalArticle

Afferent Neurons
Analgesia
Opioid Analgesics
Pain
Nerve Growth Factor
82 Citations (Scopus)

Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons

Chi, X. X., Schmutzler, B. S., Brittain, J. M., Wang, Y., Hingtgen, C. M., Nicol, G. & Khanna, R., Dec 1 2009, In : Journal of Cell Science. 122, 23, p. 4351-4362 12 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Calcium Channels
Spinal Ganglia
Semaphorin-3A
Calcitonin Gene-Related Peptide
15 Citations (Scopus)

RNA interference in cancer: Targeting the anti-apoptotic protein c-FLIP for drug discovery

Day, T. W. & Safa, A., 2009, In : Mini-Reviews in Medicinal Chemistry. 9, 6, p. 741-748 8 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Apoptosis Regulatory Proteins
Drug Discovery
RNA Interference
Gene Silencing
45 Citations (Scopus)

Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: Use of APE1 small molecule inhibitors to delineate APE1 functions

Jiang, Y., Guo, C., Fishel, M., Wang, Z. Y., Vasko, M. & Kelley, M., Nov 2 2009, In : DNA Repair. 8, 11, p. 1273-1282 10 p.

Research output: Contribution to journalArticle

Oxidative stress
Neuroblastoma
Oxidative Stress
Repair
Molecules
37 Citations (Scopus)
Glutamic Acid
Permeability
Calcium
Neurons
cyclophilin D
54 Citations (Scopus)

Role of eIF3a in regulating cell cycle progression

Dong, Z., Liu, Z., Cui, P., Pincheira, R., Yang, Y., Liu, J. & Zhang, J-T., Jul 1 2009, In : Experimental Cell Research. 315, 11, p. 1889-1894 6 p.

Research output: Contribution to journalArticle

Cell Cycle
Cell Proliferation
Peptide Initiation Factors
Gene Expression Regulation
S Phase
1 Citation (Scopus)

Selective antifolates for chemically labeling proteins in mammalian cells

Rosa, L. P. E., Reddy, D. R., Queener, S. & Miller, L. W., Jun 15 2009, In : ChemBioChem. 10, 9, p. 1462-1464 3 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
NIH 3T3 Cells
Tetrahydrofolate Dehydrogenase
Biotechnology
Microscopy
29 Citations (Scopus)

Stimulation of glutamate receptors in cultured hippocampal neurons causes Ca2+-dependent mitochondrial contraction

Brustovetsky, T., Li, V. & Broustovetski, N., Jul 2009, In : Cell Calcium. 46, 1, p. 18-29 12 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Glutamic Acid
Mitochondria
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
Neurons
13 Citations (Scopus)

The c-kit signaling pathway is involved in the development of persistent pain

Sun, Y. G., Gracias, N. G., Drobish, J. K., Vasko, M., Gereau, R. W. & Chen, Z. F., Jul 2009, In : Pain. 144, 1-2, p. 178-186 9 p.

Research output: Contribution to journalArticle

Substantia Gelatinosa
Pain
Signal Transduction
Mutation
Nociception
67 Citations (Scopus)

The divalent metal transporter homologues SMF-1/2 mediate dopamine neuron sensitivity in Caenorhabditis elegans models of manganism and Parkinson disease

Settivari, R., LeVora, J. & Nass, R., Dec 18 2009, In : Journal of Biological Chemistry. 284, 51, p. 35758-35768 11 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Caenorhabditis elegans
Neurons
Parkinson Disease
Dopamine
6 Citations (Scopus)

The Xpc gene markedly affects cell survival in mouse bone marrow

Fischer, J. L., Kumar, M. A. S., Day, T. W., Hardy, T. M., Hamilton, S., Besch-Williford, C., Safa, A., Pollok, K. & Smith, M. L., Jul 2009, In : Mutagenesis. 24, 4, p. 309-316 8 p.

Research output: Contribution to journalArticle

Cell Survival
Bone
Repair
DNA Repair
Nucleotides
33 Citations (Scopus)

Toxoplasma H2A Variants Reveal Novel Insights into Nucleosome Composition and Functions for this Histone Family

Dalmasso, M. C., Onyango, D. O., Naguleswaran, A., Sullivan, W. & Angel, S. O., Sep 11 2009, In : Journal of Molecular Biology. 392, 1, p. 33-47 15 p.

Research output: Contribution to journalArticle

Nucleosomes
Toxoplasma
Histones
Parasites
DNA Damage
85 Citations (Scopus)

Transfection of rat or mouse neurons by biolistics or electroporation

Dib-Hajj, S. D., Choi, J. S., Macala, L. J., Tyrrell, L., Black, J. A., Cummins, T. & Waxman, S. G., 2009, In : Nature Protocols. 4, 8, p. 1118-1126 9 p.

Research output: Contribution to journalArticle

Biolistics
Electroporation
Neurons
Transfection
Rats
26 Citations (Scopus)

Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii - A Review

Sullivan, W., Smith, A. T. & Joyce, B. R., Mar 2009, In : Memorias do Instituto Oswaldo Cruz. 104, 2, p. 155-161 7 p.

Research output: Contribution to journalArticle

Toxoplasma
Cysts
Parasites
Eukaryotic Initiation Factor-2
Zoonoses
61 Citations (Scopus)

Voltage-clamp and current-clamp recordings from mammalian DRG neurons

Cummins, T., Rush, A. M., Estacion, M., Dib-Hajj, S. D. & Waxman, S. G., 2009, In : Nature Protocols. 4, 8, p. 1103-1112 10 p.

Research output: Contribution to journalArticle

Clamping devices
Spinal Ganglia
Neurons
Electric potential
Voltage-Gated Sodium Channels
98 Citations (Scopus)

Voltage-gated sodium channels in pain states: Role in pathophysiology and targets for treatment

Dib-Hajj, S. D., Binshtok, A. M., Cummins, T., Jarvis, M. F., Samad, T. & Zimmermann, K., Apr 2009, In : Brain Research Reviews. 60, 1, p. 65-83 19 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Sodium Channels
Pain
Protein Isoforms
Neurons