Pharmacology & Toxicology

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2010

Augmented sodium currents contribute to the enhanced excitability of small diameter capsaicin-sensitive sensory neurons isolated from Nf1+/- mice

Wang, Y., Duan, J. H., Hingtgen, C. M. & Nicol, G. D., Apr 1 2010, In : Journal of Neurophysiology. 103, 4, p. 2085-2094 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

BAX insertion, oligomerization, and outer membrane permeabilization in brain mitochondria: Role of permeability transition and SH-redox regulation

Brustovetsky, T., Li, T., Yang, Y., Zhang, J. T., Antonsson, B. & Brustovetsky, N., Nov 1 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 11, p. 1795-1806 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
31 Scopus citations
17 Scopus citations
6 Scopus citations

Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens

Bag, S., Tawari, N. R., Degani, M. S. & Queener, S. F., May 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 9, p. 3187-3197 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Dissimilar mechanisms of cytochrome c release induced by octyl glucoside-activated BAX and by BAX activated with truncated BID

Li, T., Brustovetsky, T., Antonsson, B. & Brustovetsky, N., Jan 1 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 1, p. 52-62 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Diversifying biomedical training: A synergistic intervention

Gibau, G. S., Foertsch, J., Blum, J., Brutkiewicz, R., Queener, S., Roman, A., Rhodes, S., Sturek, M., Wilkes, D. & Broxmeyer, H., Dec 1 2010, In : Journal of Women and Minorities in Science and Engineering. 16, 3, p. 215-235 21 p.

Research output: Contribution to journalArticle

10 Scopus citations

Dynamic vs static ABCG2 inhibitors to sensitize drug resistant cancer cells

Peng, H., Qi, J., Dong, Z. & Zhang, J. T., Dec 20 2010, In : PloS one. 5, 12, e15276.

Research output: Contribution to journalArticle

29 Scopus citations

Effects of low-level light therapy on streptozotocin-induced diabetic kidney

Lim, J., Sanders, R. A., Snyder, A. C., Eells, J. T., Henshel, D. S. & Watkins, J. B., May 1 2010, In : Journal of Photochemistry and Photobiology B: Biology. 99, 2, p. 105-110 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Global microRNA expression profiling of caenorhabditis elegans Parkinson's disease models

Asikainen, S., Rudgalvyte, M., Heikkinen, L., Louhiranta, K., Lakso, M., Wong, G. & Nass, R., May 1 2010, In : Journal of Molecular Neuroscience. 41, 1, p. 210-218 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

Jarecki, B. W., Piekarz, A. D., Jackson, J. O. & Cummins, T. R., Jan 4 2010, In : Journal of Clinical Investigation. 120, 1, p. 369-378 10 p.

Research output: Contribution to journalArticle

89 Scopus citations

Identification of novel small molecule inhibitors of the XPA protein using in silico based screening

Neher, T. M., Shuck, S. C., Liu, J. Y., Zhang, J. T. & Turchi, J. J., Oct 15 2010, In : ACS Chemical Biology. 5, 10, p. 953-965 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

In Silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation

Wang, Y., Brittain, J. M., Jarecki, B. W., Park, K. D., Wilson, S. M., Wang, B., Hale, R., Meroueh, S. O., Cummins, T. R. & Khanna, R., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25296-25307 12 p.

Research output: Contribution to journalArticle

60 Scopus citations

Interaction between DNA polymerase λ and anticancer nucleoside analogs

Garcia-Diaz, M., Murray, M. S., Kunkel, T. A. & Chou, K. M., May 28 2010, In : Journal of Biological Chemistry. 285, 22, p. 16874-16879 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

MYST family lysine acetyltransferase facilitates Ataxia Telangiectasia Mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii

Vonlaufen, N., Naguleswaran, A., Coppens, I. & Sullivan, W. J., Apr 9 2010, In : Journal of Biological Chemistry. 285, 15, p. 11154-11161 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Neuroprotective effect of KB-r7943 against glutamate excitotoxicity is related to mild mitochondrial depolarization

Storozhevykh, T. P., Senilova, Y. E., Brustovetsky, T., Pinelis, V. G. & Brustovetsky, N., Feb 1 2010, In : Neurochemical Research. 35, 2, p. 323-335 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
48 Scopus citations

Regulation of NF-κB by NSD1/FBXL11-dependent reversible lysine methylation of p65

Lu, T., Jackson, M. W., Wang, B., Yang, M., Chance, M. R., Miyagi, M., Gudkov, A. V. & Stark, G. R., Feb 15 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle

166 Scopus citations

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

Yang, J., Huang, J., Dasgupta, M., Sears, N., Miyagi, M., Wang, B., Chance, M. R., Chen, X., Du, Y., Wang, Y., An, L., Wang, Q., Lu, T., Zhang, X., Wang, Z. & Stark, G. R., Dec 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21499-21504 6 p.

Research output: Contribution to journalArticle

163 Scopus citations

Role of 14-3-3σ in poor prognosis and in radiation and drug resistance of human pancreatic cancers

Li, Z., Dong, Z., Myer, D., Yip-Schneider, M., Liu, J., Cui, P., Schmidt, C. M. & Zhang, J. T., Nov 1 2010, In : BMC Cancer. 10, 598.

Research output: Contribution to journalArticle

28 Scopus citations

Role of transmembrane segment 5 and extracellular loop 3 in the homodimerization of human ABCC1

Yang, Y., Mo, W. & Zhang, J. T., Dec 28 2010, In : Biochemistry. 49, 51, p. 10854-10861 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
17 Scopus citations
16 Scopus citations

Signaling pathways that mediate nerve growth factor-induced increase in expression and release of calcitonin gene-related peptide from sensory neurons

Park, K. A., Fehrenbacher, J. C., Thompson, E. L., Duarte, D. B., Hingtgen, C. M. & Vasko, M. R., Dec 15 2010, In : Neuroscience. 171, 3, p. 910-923 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

SKN-1/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity

VanDuyn, N., Settivari, R., Wong, G. & Nass, R., Dec 1 2010, In : Toxicological Sciences. 118, 2, p. 613-624 12 p., kfq285.

Research output: Contribution to journalArticle

63 Scopus citations

Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex

Anderson, C. T., Sheets, P. L., Kiritani, T. & Shepherd, G. M. G., Jun 1 2010, In : Nature Neuroscience. 13, 6, p. 739-744 6 p.

Research output: Contribution to journalArticle

139 Scopus citations
12 Scopus citations

The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands

Zhang, M., Fennell, C., Ranford-Cartwright, L., Sakthivel, R., Gueirard, P., Meister, S., Caspi, A., Doerig, C., Nussenzweig, R. S., Tuteja, R., Sullivan, W. J., Roos, D. S., Fontoura, B. M. A., Ménard, R., Winzeler, E. A. & Nussenzweig, V., Jul 5 2010, In : Journal of Experimental Medicine. 207, 7, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

86 Scopus citations
35 Scopus citations

The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation

Xiao, Y., Blumenthal, K., Jackson, J. O., Liang, S. & Cummins, T. R., Dec 1 2010, In : Molecular Pharmacology. 78, 6, p. 1124-1134 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Toxoplasma gondii lysine acetyltransferase GCN5-a functions in the cellular response to alkaline stress and expression of cyst genes

Naguleswaran, A., Elias, E. V., McClintick, J., Edenberg, H. J. & Sullivan, W. J., Dec 1 2010, In : PLoS pathogens. 6, 12, e1001232.

Research output: Contribution to journalArticle

25 Scopus citations
2009

Alternative splicing of NaV1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T

Jarecki, B. W., Sheets, P. L., Xiao, Y., Jackson, J. O. & Cummins, T. R., Jan 1 2009, In : Channels. 3, 4

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels

Brittain, J. M., Piekarz, A. D., Wang, Y., Kondo, T., Cummins, T. R. & Khanna, R., Nov 6 2009, In : Journal of Biological Chemistry. 284, 45, p. 31375-31390 16 p.

Research output: Contribution to journalArticle

130 Scopus citations

A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapy

Peng, H., Dong, Z., Qi, J., Yang, Y., Liu, Y., Li, Z., Xu, J. & Zhang, J. T., May 24 2009, In : PLoS ONE. 4, 5, e5676.

Research output: Contribution to journalArticle

38 Scopus citations

Capsaicin-evoked iCGRP release from human dental pulp: A model system for the study of peripheral neuropeptide secretion in normal healthy tissue

Fehrenbacher, J. C., Sun, X. X., Locke, E. E., Henry, M. A. & Hargreaves, K. M., Aug 1 2009, In : Pain. 144, 3, p. 253-261 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

C-FLIP gene silencing eliminates tumor cells in breast cancer xenografts without affecting stromal cells

Day, T. W., Sinn, A. L., Huang, S., Pollok, K. E., Sandusky, G. E. & Safa, A. R., Oct 1 2009, In : Anticancer Research. 29, 10, p. 3883-3886 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population

Yin, J. Y., Huang, Q., Yang, Y., Zhang, J. T., Zhong, M. Z., Zhou, H. H. & Liu, Z. Q., Mar 1 2009, In : Pharmacogenetics and Genomics. 19, 3, p. 206-216 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Chronic unpredictable stress augments +3,4-methylenedioxymethamphetamine-induced monoamine depletions: The role of corticosterone

Johnson, B. N. & Yamamoto, B. K., Apr 10 2009, In : Neuroscience. 159, 4, p. 1233-1243 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes

Cody, V., Pace, J., Makin, J., Piraino, J., Queener, S. F. & Rosowsky, A., Mar 3 2009, In : Biochemistry. 48, 8, p. 1702-1711 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors

Gangjee, A., Li, W., Lin, L., Zeng, Y., Ihnat, M., Warnke, L. A., Green, D. W., Cody, V., Pace, J. & Queener, S. F., Oct 15 2009, In : Bioorganic and Medicinal Chemistry. 17, 20, p. 7324-7336 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Disruption of a mitochondrial MutS DNA repair enzyme homologue confers drug resistance in the parasite Toxoplasma gondii

Garrison, E. M. & Arrizabalaga, G., Apr 1 2009, In : Molecular Microbiology. 72, 2, p. 425-441 17 p.

Research output: Contribution to journalArticle

26 Scopus citations

Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells

Shen, F., Bailey, B. J., Chu, S., Bence, A. K., Xue, X., Erickson, P., Safa, A. R., Beck, W. T. & Erickson, L. C., Aug 1 2009, In : Journal of Pharmacology and Experimental Therapeutics. 330, 2, p. 423-429 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Early and Late Contributions of Glutamate and CGRP to Mechanical Sensitization by Endothelin-1

Khodorova, A., Richter, J., Vasko, M. R. & Strichartz, G., Jul 1 2009, In : Journal of Pain. 10, 7, p. 740-749 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Effects of low-level light therapy on hepatic antioxidant defense in acute and chronic diabetic rats

Lim, J., Ali, Z. M., Sanders, R. A., Snyder, A. C., Eells, J. T., Henshel, D. S. & Watkins, J. B., Jan 1 2009, In : Journal of Biochemical and Molecular Toxicology. 23, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Etoposide induces protein kinase Cδ- and caspase-3-dependent apoptosis in neuroblastoma cancer cells

Day, T. W., Wu, C. H. & Safa, A. R., Sep 1 2009, In : Molecular pharmacology. 76, 3, p. 632-640 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Evaluation of urothelial stretch-induced cyclooxygenase-2 expression in a mouse ureteral obstruction model

Sterrett, S. P., Wilkinson, E. R., Jerde, T. J., Mellon, W. S. & Nakada, S. Y., Mar 1 2009, In : Journal of Endourology. 23, 3, p. 541-544 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
17 Scopus citations

IL-1 induces IGF-dependent epithelial proliferation in prostate development and reactive hyperplasia

Jerde, T. J. & Bushman, W., Sep 1 2009, In : Science Signaling. 2, 86, p. ra49

Research output: Contribution to journalArticle

34 Scopus citations

Induction of mitotic S-phase of host and neighboring cells by Toxoplasma gondii enhances parasite invasion

Lavine, M. D. & Arrizabalaga, G., Mar 1 2009, In : Molecular and Biochemical Parasitology. 164, 1, p. 95-99 5 p.

Research output: Contribution to journalArticle

23 Scopus citations