Pharmacology & Toxicology

Publications

Filter
Article
2010

The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation

Xiao, Y., Blumenthal, K., Jackson, J. O., Liang, S. & Cummins, T. R., Dec 1 2010, In : Molecular Pharmacology. 78, 6, p. 1124-1134 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

Toxoplasma gondii lysine acetyltransferase GCN5-a functions in the cellular response to alkaline stress and expression of cyst genes

Naguleswaran, A., Elias, E. V., McClintick, J., Edenberg, H. J. & Sullivan, W. J., Dec 1 2010, In : PLoS pathogens. 6, 12, e1001232.

Research output: Contribution to journalArticle

29 Scopus citations
2009

Alternative splicing of NaV1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T

Jarecki, B. W., Sheets, P. L., Xiao, Y., Jackson, J. O. & Cummins, T. R., Jan 1 2009, In : Channels. 3, 4

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels

Brittain, J. M., Piekarz, A. D., Wang, Y., Kondo, T., Cummins, T. R. & Khanna, R., Nov 6 2009, In : Journal of Biological Chemistry. 284, 45, p. 31375-31390 16 p.

Research output: Contribution to journalArticle

136 Scopus citations

A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapy

Peng, H., Dong, Z., Qi, J., Yang, Y., Liu, Y., Li, Z., Xu, J. & Zhang, J. T., May 24 2009, In : PloS one. 4, 5, e5676.

Research output: Contribution to journalArticle

38 Scopus citations

C-FLIP gene silencing eliminates tumor cells in breast cancer xenografts without affecting stromal cells

Day, T. W., Sinn, A. L., Huang, S., Pollok, K. E., Sandusky, G. E. & Safa, A. R., Oct 1 2009, In : Anticancer Research. 29, 10, p. 3883-3886 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population

Yin, J. Y., Huang, Q., Yang, Y., Zhang, J. T., Zhong, M. Z., Zhou, H. H. & Liu, Z. Q., Mar 1 2009, In : Pharmacogenetics and Genomics. 19, 3, p. 206-216 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes

Cody, V., Pace, J., Makin, J., Piraino, J., Queener, S. F. & Rosowsky, A., Mar 3 2009, In : Biochemistry. 48, 8, p. 1702-1711 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors

Gangjee, A., Li, W., Lin, L., Zeng, Y., Ihnat, M., Warnke, L. A., Green, D. W., Cody, V., Pace, J. & Queener, S. F., Oct 15 2009, In : Bioorganic and Medicinal Chemistry. 17, 20, p. 7324-7336 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells

Shen, F., Bailey, B. J., Chu, S., Bence, A. K., Xue, X., Erickson, P., Safa, A. R., Beck, W. T. & Erickson, L. C., Aug 1 2009, In : Journal of Pharmacology and Experimental Therapeutics. 330, 2, p. 423-429 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Early and Late Contributions of Glutamate and CGRP to Mechanical Sensitization by Endothelin-1

Khodorova, A., Richter, J., Vasko, M. R. & Strichartz, G., Jul 1 2009, In : Journal of Pain. 10, 7, p. 740-749 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Effects of low-level light therapy on hepatic antioxidant defense in acute and chronic diabetic rats

Lim, J., Ali, Z. M., Sanders, R. A., Snyder, A. C., Eells, J. T., Henshel, D. S. & Watkins, J. B., Jan 1 2009, In : Journal of Biochemical and Molecular Toxicology. 23, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Etoposide induces protein kinase Cδ- and caspase-3-dependent apoptosis in neuroblastoma cancer cells

Day, T. W., Wu, C. H. & Safa, A. R., Sep 1 2009, In : Molecular pharmacology. 76, 3, p. 632-640 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
18 Scopus citations

Local Antinociception Induced by Endothelin-1 in the Hairy Skin of the Rat's Back

Shrestha, S., Gracias, N. G., Mujenda, F., Khodorova, A., Vasko, M. R. & Strichartz, G. R., Jul 1 2009, In : Journal of Pain. 10, 7, p. 702-714 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

MDMA Pretreatment Leads to Mild Chronic Unpredictable Stress-Induced Impairments in Spatial Learning

Cunningham, J. I., Raudensky, J., Tonkiss, J. & Yamamoto, B. K., Oct 1 2009, In : Behavioral Neuroscience. 123, 5, p. 1076-1084 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons

Chi, X. X., Schmutzler, B. S., Brittain, J. M., Wang, Y., Hingtgen, C. M., Nicol, G. D. & Khanna, R., Dec 1 2009, In : Journal of cell science. 122, 23, p. 4351-4362 12 p.

Research output: Contribution to journalArticle

92 Scopus citations

RNA interference in cancer: Targeting the anti-apoptotic protein c-FLIP for drug discovery

Day, T. W. & Safa, A. R., Sep 21 2009, In : Mini-Reviews in Medicinal Chemistry. 9, 6, p. 741-748 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
45 Scopus citations

Role of cyclophilin D-dependent mitochondrial permeability transition in glutamate-induced calcium deregulation and excitotoxic neuronal death

Li, V., Brustovetsky, T. & Brustovetsky, N., Aug 1 2009, In : Experimental Neurology. 218, 2, p. 171-182 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Role of eIF3a in regulating cell cycle progression

Dong, Z., Liu, Z., Cui, P., Pincheira, R., Yang, Y., Liu, J. & Zhang, J. T., Jul 1 2009, In : Experimental Cell Research. 315, 11, p. 1889-1894 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Selective antifolates for chemically labeling proteins in mammalian cells

Rosa, L. P. E., Reddy, D. R., Queener, S. F. & Miller, L. W., Jun 15 2009, In : ChemBioChem. 10, 9, p. 1462-1464 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Stimulation of glutamate receptors in cultured hippocampal neurons causes Ca2+-dependent mitochondrial contraction

Brustovetsky, T., Li, V. & Brustovetsky, N., Jul 2009, In : Cell Calcium. 46, 1, p. 18-29 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

The c-kit signaling pathway is involved in the development of persistent pain

Sun, Y. G., Gracias, N. G., Drobish, J. K., Vasko, M. R., Gereau, R. W. & Chen, Z. F., Jul 1 2009, In : Pain. 144, 1-2, p. 178-186 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

The divalent metal transporter homologues SMF-1/2 mediate dopamine neuron sensitivity in Caenorhabditis elegans models of manganism and Parkinson disease

Settivari, R., LeVora, J. & Nass, R., Dec 18 2009, In : Journal of Biological Chemistry. 284, 51, p. 35758-35768 11 p.

Research output: Contribution to journalArticle

70 Scopus citations

The Xpc gene markedly affects cell survival in mouse bone marrow

Fischer, J. L., Kumar, M. A. S., Day, T. W., Hardy, T. M., Hamilton, S., Besch-Williford, C., Safa, A. R., Pollok, K. E. & Smith, M. L., Jul 1 2009, In : Mutagenesis. 24, 4, p. 309-316 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Toxoplasma H2A Variants Reveal Novel Insights into Nucleosome Composition and Functions for this Histone Family

Dalmasso, M. C., Onyango, D. O., Naguleswaran, A., Sullivan, W. J. & Angel, S. O., Sep 11 2009, In : Journal of molecular biology. 392, 1, p. 33-47 15 p.

Research output: Contribution to journalArticle

33 Scopus citations

Transfection of rat or mouse neurons by biolistics or electroporation

Dib-Hajj, S. D., Choi, J. S., Macala, L. J., Tyrrell, L., Black, J. A., Cummins, T. R. & Waxman, S. G., Aug 17 2009, In : Nature protocols. 4, 8, p. 1118-1126 9 p.

Research output: Contribution to journalArticle

86 Scopus citations

Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii - A Review

Sullivan, W. J., Smith, A. T. & Joyce, B. R., Mar 2009, In : Memorias do Instituto Oswaldo Cruz. 104, 2, p. 155-161 7 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Voltage-clamp and current-clamp recordings from mammalian DRG neurons

Cummins, T. R., Rush, A. M., Estacion, M., Dib-Hajj, S. D. & Waxman, S. G., Aug 17 2009, In : Nature protocols. 4, 8, p. 1103-1112 10 p.

Research output: Contribution to journalArticle

66 Scopus citations
2008

Analysis of changes in the proteome of HL-60 promyeloid leukemia cells induced by the proteasome inhibitor PSI

Choi, M. R., Najafi, F., Safa, A. R. & Drexler, H. C. A., Jun 15 2008, In : Biochemical Pharmacology. 75, 12, p. 2276-2288 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

A new mechanism of drug resistance in breast cancer cells: Fatty acid synthase overexpression-mediated palmitate overproduction

Liu, H., Liu, Y. & Zhang, J. T., Feb 1 2008, In : Molecular cancer therapeutics. 7, 2, p. 263-270 8 p.

Research output: Contribution to journalArticle

113 Scopus citations

Attenuation of TCDD-induced oxidative stress by 670 nm photobiomodulation in developmental chicken kidney

Lim, J., Sanders, R. A., Yeager, R. L., Millsap, D. S., Watkins, J. B., Eells, J. T. & Henshel, D. S., Sep 9 2008, In : Journal of Biochemical and Molecular Toxicology. 22, 4, p. 230-239 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Azurin-like protein blocks invasion of Toxoplasma gondii through potential interactions with parasite surface antigen SAG1

Naguleswaran, A., Fialho, A. M., Chaudhari, A., Chang, S. H., Chakrabarty, A. M. & Sullivan, W. J., Feb 1 2008, In : Antimicrobial Agents and Chemotherapy. 52, 2, p. 402-408 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
38 Scopus citations

c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells

Day, T. W., Huang, S. & Safa, A. R., Dec 15 2008, In : Biochemical Pharmacology. 76, 12, p. 1694-1704 11 p.

Research output: Contribution to journalArticle

62 Scopus citations
143 Scopus citations

Effect of cysteine mutagenesis on the function and disulfide bond formation of human ABCG2

Liu, Y., Yang, Y., Qi, J., Peng, H. & Zhang, J. T., Jul 1 2008, In : Journal of Pharmacology and Experimental Therapeutics. 326, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Human DNA polymerase η activity and translocation is regulated by phosphorylation

Chen, Y. W., Cleaver, J. E., Hatahet, Z., Honkanen, R. E., Chang, J. Y., Yen, Y. & Chou, K. M., Oct 28 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16578-16583 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
90 Scopus citations

Intrinsic disorder in pathogenic and non-pathogenic microbes: Discovering and analyzing the unfoldomes of early-branching eukaryotes

Mohan, A., Sullivan, W. J., Radivojac, P., Dunker, A. K. & Uversky, V. N., Mar 28 2008, In : Molecular BioSystems. 4, 4, p. 328-340 13 p.

Research output: Contribution to journalArticle

92 Scopus citations

L-DOPA-induced activation of striatal p38MAPK and CREB in neonatal dopaminergic denervated rat: Relevance to self-injurious behavior

Sivam, S. P., Pugazhenthi, S., Pugazhenthi, V. & Brown, H., Feb 1 2008, In : Journal of Neuroscience Research. 86, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Measurements of mitochondrial pH in cultured cortical neurons clarify contribution of mitochondrial pore to the mechanism of glutamate-induced delayed Ca2+ deregulation

Bolshakov, A. P., Mikhailova, M. M., Szabadkai, G., Pinelis, V. G., Brustovetsky, N., Rizzuto, R. & Khodorov, B. I., Jun 2008, In : Cell Calcium. 43, 6, p. 602-614 13 p.

Research output: Contribution to journalArticle

37 Scopus citations
33 Scopus citations

Nerve growth factor, sphingomyelins, and sensitization in sensory neurons

Nicol, G. D., Oct 25 2008, In : Sheng li xue bao : [Acta physiologica Sinica]. 60, 5, p. 603-604 2 p.

Research output: Contribution to journalArticle

11 Scopus citations

N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons

Rimmerman, N., Bradshaw, H. B., Hughes, H. V., Chen, J. S. C., Hu, S. S. J., McHugh, D., Vefring, E., Jahnsen, J. A., Thompson, E. L., Masuda, K., Cravatt, B. F., Burstein, S., Vasko, M. R., Prieto, A. L., O'Dell, D. K. & Walker, J. M., Jul 1 2008, In : Molecular pharmacology. 74, 1, p. 213-224 12 p.

Research output: Contribution to journalArticle

60 Scopus citations

Oligomeric BAX induces mitochondrial permeability transition and complete cytochrome c release without oxidative stress

Li, T., Brustovetsky, T., Antonsson, B. & Brustovetsky, N., Nov 1 2008, In : Biochimica et Biophysica Acta - Bioenergetics. 1777, 11, p. 1409-1421 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Paroxysmal extreme pain disorder M1627K mutation in human Nav 1.7 renders DRG neurons hyperexcitable

Dib-Hajj, S. D., Estacion, M., Jarecki, B. W., Tyrrell, L., Fischer, T. Z., Lawden, M., Cummins, T. R. & Waxman, S. G., Sep 19 2008, In : Molecular Pain. 4, 37.

Research output: Contribution to journalArticle

87 Scopus citations

Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation

Jarecki, B. W., Sheets, P. L., Jackson, J. O. & Cummins, T. R., Jan 1 2008, In : Journal of Physiology. 586, 17, p. 4137-4153 17 p.

Research output: Contribution to journalArticle

61 Scopus citations

Preparation and evaluation of a high-strength biocompatible glass-ionomer cement for improved dental restoratives.

Xie, D., Zhao, J., Yang, Y., Park, J., Chu, T. M. & Zhang, J. T., Jun 2008, In : Biomedical materials (Bristol, England). 3, 2, 1 p.

Research output: Contribution to journalArticle

4 Scopus citations