Pharmacology & Toxicology

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2010

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

Jarecki, B. W., Piekarz, A. D., Jackson, J. O. & Cummins, T. R., Jan 4 2010, In : Journal of Clinical Investigation. 120, 1, p. 369-378 10 p.

Research output: Contribution to journalArticle

94 Scopus citations

Identification of novel small molecule inhibitors of the XPA protein using in silico based screening

Neher, T. M., Shuck, S. C., Liu, J. Y., Zhang, J. T. & Turchi, J. J., Oct 15 2010, In : ACS chemical biology. 5, 10, p. 953-965 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

In Silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation

Wang, Y., Brittain, J. M., Jarecki, B. W., Park, K. D., Wilson, S. M., Wang, B., Hale, R., Meroueh, S. O., Cummins, T. R. & Khanna, R., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25296-25307 12 p.

Research output: Contribution to journalArticle

61 Scopus citations

Interaction between DNA polymerase λ and anticancer nucleoside analogs

Garcia-Diaz, M., Murray, M. S., Kunkel, T. A. & Chou, K. M., May 28 2010, In : Journal of Biological Chemistry. 285, 22, p. 16874-16879 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

MYST family lysine acetyltransferase facilitates Ataxia Telangiectasia Mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii

Vonlaufen, N., Naguleswaran, A., Coppens, I. & Sullivan, W. J., Apr 9 2010, In : Journal of Biological Chemistry. 285, 15, p. 11154-11161 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Neuroprotective effect of KB-r7943 against glutamate excitotoxicity is related to mild mitochondrial depolarization

Storozhevykh, T. P., Senilova, Y. E., Brustovetsky, T., Pinelis, V. G. & Brustovetsky, N., Feb 1 2010, In : Neurochemical Research. 35, 2, p. 323-335 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
50 Scopus citations

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

Yang, J., Huang, J., Dasgupta, M., Sears, N., Miyagi, M., Wang, B., Chance, M. R., Chen, X., Du, Y., Wang, Y., An, L., Wang, Q., Lu, T., Zhang, X., Wang, Z. & Stark, G. R., Dec 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21499-21504 6 p.

Research output: Contribution to journalArticle

173 Scopus citations

Role of 14-3-3σ in poor prognosis and in radiation and drug resistance of human pancreatic cancers

Li, Z., Dong, Z., Myer, D., Yip-Schneider, M., Liu, J., Cui, P., Schmidt, C. M. & Zhang, J. T., Nov 1 2010, In : BMC Cancer. 10, 598.

Research output: Contribution to journalArticle

29 Scopus citations

Role of transmembrane segment 5 and extracellular loop 3 in the homodimerization of human ABCC1

Yang, Y., Mo, W. & Zhang, J. T., Dec 28 2010, In : Biochemistry. 49, 51, p. 10854-10861 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
17 Scopus citations

Signaling pathways that mediate nerve growth factor-induced increase in expression and release of calcitonin gene-related peptide from sensory neurons

Park, K. A., Fehrenbacher, J. C., Thompson, E. L., Duarte, D. B., Hingtgen, C. M. & Vasko, M. R., Dec 15 2010, In : Neuroscience. 171, 3, p. 910-923 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

SKN-1/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity

VanDuyn, N., Settivari, R., Wong, G. & Nass, R., Dec 2010, In : Toxicological Sciences. 118, 2, p. 613-624 12 p., kfq285.

Research output: Contribution to journalArticle

67 Scopus citations
12 Scopus citations

The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands

Zhang, M., Fennell, C., Ranford-Cartwright, L., Sakthivel, R., Gueirard, P., Meister, S., Caspi, A., Doerig, C., Nussenzweig, R. S., Tuteja, R., Sullivan, W. J., Roos, D. S., Fontoura, B. M. A., Ménard, R., Winzeler, E. A. & Nussenzweig, V., Jul 5 2010, In : Journal of Experimental Medicine. 207, 7, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

86 Scopus citations
38 Scopus citations

The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation

Xiao, Y., Blumenthal, K., Jackson, J. O., Liang, S. & Cummins, T. R., Dec 1 2010, In : Molecular Pharmacology. 78, 6, p. 1124-1134 11 p.

Research output: Contribution to journalArticle

81 Scopus citations

Toxoplasma gondii lysine acetyltransferase GCN5-a functions in the cellular response to alkaline stress and expression of cyst genes

Naguleswaran, A., Elias, E. V., McClintick, J., Edenberg, H. J. & Sullivan, W. J., 2010, In : PLoS pathogens. 6, 12, e1001232.

Research output: Contribution to journalArticle

29 Scopus citations
2009

Alternative splicing of NaV1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T

Jarecki, B. W., Sheets, P. L., Xiao, Y., Jackson, J. O. & Cummins, T. R., Jan 1 2009, In : Channels. 3, 4

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels

Brittain, J. M., Piekarz, A. D., Wang, Y., Kondo, T., Cummins, T. R. & Khanna, R., Nov 6 2009, In : Journal of Biological Chemistry. 284, 45, p. 31375-31390 16 p.

Research output: Contribution to journalArticle

138 Scopus citations

A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapy

Peng, H., Dong, Z., Qi, J., Yang, Y., Liu, Y., Li, Z., Xu, J. & Zhang, J. T., May 24 2009, In : PloS one. 4, 5, e5676.

Research output: Contribution to journalArticle

38 Scopus citations

C-FLIP gene silencing eliminates tumor cells in breast cancer xenografts without affecting stromal cells

Day, T. W., Sinn, A. L., Huang, S., Pollok, K. E., Sandusky, G. E. & Safa, A. R., Oct 1 2009, In : Anticancer Research. 29, 10, p. 3883-3886 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population

Yin, J. Y., Huang, Q., Yang, Y., Zhang, J. T., Zhong, M. Z., Zhou, H. H. & Liu, Z. Q., Mar 2009, In : Pharmacogenetics and Genomics. 19, 3, p. 206-216 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes

Cody, V., Pace, J., Makin, J., Piraino, J., Queener, S. F. & Rosowsky, A., Mar 3 2009, In : Biochemistry. 48, 8, p. 1702-1711 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors

Gangjee, A., Li, W., Lin, L., Zeng, Y., Ihnat, M., Warnke, L. A., Green, D. W., Cody, V., Pace, J. & Queener, S. F., Oct 15 2009, In : Bioorganic and Medicinal Chemistry. 17, 20, p. 7324-7336 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Disruption of a mitochondrial MutS DNA repair enzyme homologue confers drug resistance in the parasite Toxoplasma gondii

Garrison, E. M. & Arrizabalaga, G., Apr 2009, In : Molecular Microbiology. 72, 2, p. 425-441 17 p.

Research output: Contribution to journalArticle

29 Scopus citations

Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells

Shen, F., Bailey, B. J., Chu, S., Bence, A. K., Xue, X., Erickson, P., Safa, A. R., Beck, W. T. & Erickson, L. C., Aug 2009, In : Journal of Pharmacology and Experimental Therapeutics. 330, 2, p. 423-429 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Early and Late Contributions of Glutamate and CGRP to Mechanical Sensitization by Endothelin-1

Khodorova, A., Richter, J., Vasko, M. R. & Strichartz, G., Jul 1 2009, In : Journal of Pain. 10, 7, p. 740-749 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Effects of low-level light therapy on hepatic antioxidant defense in acute and chronic diabetic rats

Lim, J., Ali, Z. M., Sanders, R. A., Snyder, A. C., Eells, J. T., Henshel, D. S. & Watkins, J. B., Jan 1 2009, In : Journal of Biochemical and Molecular Toxicology. 23, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Etoposide induces protein kinase Cδ- and caspase-3-dependent apoptosis in neuroblastoma cancer cells

Day, T. W., Wu, C. H. & Safa, A. R., Sep 1 2009, In : Molecular pharmacology. 76, 3, p. 632-640 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
19 Scopus citations

Local Antinociception Induced by Endothelin-1 in the Hairy Skin of the Rat's Back

Shrestha, S., Gracias, N. G., Mujenda, F., Khodorova, A., Vasko, M. R. & Strichartz, G. R., Jul 1 2009, In : Journal of Pain. 10, 7, p. 702-714 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

MDMA Pretreatment Leads to Mild Chronic Unpredictable Stress-Induced Impairments in Spatial Learning

Cunningham, J. I., Raudensky, J., Tonkiss, J. & Yamamoto, B. K., Oct 2009, In : Behavioral Neuroscience. 123, 5, p. 1076-1084 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons

Chi, X. X., Schmutzler, B. S., Brittain, J. M., Wang, Y., Hingtgen, C. M., Nicol, G. D. & Khanna, R., Dec 1 2009, In : Journal of cell science. 122, 23, p. 4351-4362 12 p.

Research output: Contribution to journalArticle

93 Scopus citations

RNA interference in cancer: Targeting the anti-apoptotic protein c-FLIP for drug discovery

Day, T. W. & Safa, A. R., Sep 21 2009, In : Mini-Reviews in Medicinal Chemistry. 9, 6, p. 741-748 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
46 Scopus citations

Role of cyclophilin D-dependent mitochondrial permeability transition in glutamate-induced calcium deregulation and excitotoxic neuronal death

Li, V., Brustovetsky, T. & Brustovetsky, N., Aug 1 2009, In : Experimental Neurology. 218, 2, p. 171-182 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Role of eIF3a in regulating cell cycle progression

Dong, Z., Liu, Z., Cui, P., Pincheira, R., Yang, Y., Liu, J. & Zhang, J. T., Jul 1 2009, In : Experimental Cell Research. 315, 11, p. 1889-1894 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Selective antifolates for chemically labeling proteins in mammalian cells

Rosa, L. P. E., Reddy, D. R., Queener, S. F. & Miller, L. W., Jun 15 2009, In : ChemBioChem. 10, 9, p. 1462-1464 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Stimulation of glutamate receptors in cultured hippocampal neurons causes Ca2+-dependent mitochondrial contraction

Brustovetsky, T., Li, V. & Brustovetsky, N., Jul 2009, In : Cell Calcium. 46, 1, p. 18-29 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

The c-kit signaling pathway is involved in the development of persistent pain

Sun, Y. G., Gracias, N. G., Drobish, J. K., Vasko, M. R., Gereau, R. W. & Chen, Z. F., Jul 1 2009, In : Pain. 144, 1-2, p. 178-186 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

The divalent metal transporter homologues SMF-1/2 mediate dopamine neuron sensitivity in Caenorhabditis elegans models of manganism and Parkinson disease

Settivari, R., LeVora, J. & Nass, R., Dec 18 2009, In : Journal of Biological Chemistry. 284, 51, p. 35758-35768 11 p.

Research output: Contribution to journalArticle

70 Scopus citations

The Xpc gene markedly affects cell survival in mouse bone marrow

Fischer, J. L., Kumar, M. A. S., Day, T. W., Hardy, T. M., Hamilton, S., Besch-Williford, C., Safa, A. R., Pollok, K. E. & Smith, M. L., Jul 2009, In : Mutagenesis. 24, 4, p. 309-316 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Toxoplasma H2A Variants Reveal Novel Insights into Nucleosome Composition and Functions for this Histone Family

Dalmasso, M. C., Onyango, D. O., Naguleswaran, A., Sullivan, W. J. & Angel, S. O., Sep 11 2009, In : Journal of molecular biology. 392, 1, p. 33-47 15 p.

Research output: Contribution to journalArticle

34 Scopus citations

Transfection of rat or mouse neurons by biolistics or electroporation

Dib-Hajj, S. D., Choi, J. S., Macala, L. J., Tyrrell, L., Black, J. A., Cummins, T. R. & Waxman, S. G., Aug 17 2009, In : Nature protocols. 4, 8, p. 1118-1126 9 p.

Research output: Contribution to journalArticle

87 Scopus citations

Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii - A Review

Sullivan, W. J., Smith, A. T. & Joyce, B. R., Mar 2009, In : Memorias do Instituto Oswaldo Cruz. 104, 2, p. 155-161 7 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFκB

Lu, T., Jackson, M. W., Singhi, A. D., Kandel, E. S., Yang, M., Zhang, Y., Gudkov, A. V. & Stark, G. R., Sep 22 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 38, p. 16339-16344 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Voltage-clamp and current-clamp recordings from mammalian DRG neurons

Cummins, T. R., Rush, A. M., Estacion, M., Dib-Hajj, S. D. & Waxman, S. G., Aug 17 2009, In : Nature protocols. 4, 8, p. 1103-1112 10 p.

Research output: Contribution to journalArticle

69 Scopus citations
2008

A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence

Saeij, J. P. J., Arrizabalaga, G. & Boothroyd, J. C., Jun 2008, In : Infection and immunity. 76, 6, p. 2402-2410 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1

Jeske, N. A., Diogenes, A., Ruparel, N. B., Fehrenbacher, J. C., Henry, M., Akopian, A. N. & Hargreaves, K. M., Sep 15 2008, In : Pain. 138, 3, p. 604-616 13 p.

Research output: Contribution to journalArticle

78 Scopus citations