Pharmacology & Toxicology

Publications 1970 2020

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1991
83 Citations (Scopus)

Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by α-adrenergic receptor antagonists

Ono, H., Mishima, A., Ono, S., Fukuda, H. & Vasko, M. R., Jun 1991, In : Neuropharmacology. 30, 6, p. 585-589 5 p.

Research output: Contribution to journalArticle

Adrenergic Antagonists
Clonidine
Substance P
Spinal Cord
Piperoxan
1 Citation (Scopus)

Inoculated mouse model of Pneumocystis carinii pneumonia.

Bartlett, M. S., Queener, S. F., Durkin, M. M., Shaw, M. M. & Smith, J. W., Jan 1 1991, In : The Journal of protozoology. 38, 6, p. 130S-131S

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Pneumocystis Infections
Pneumocystis carinii
Sulfamethoxazole Drug Combination Trimethoprim
Animal Models
32 Citations (Scopus)

In vitro activities of acridone alkaloids against Pneumocystis carinii

Queener, S. F., Fujioka, H., Nishiyama, Y., Furukawa, H., Bartlett, M. S. & Smith, J. W., Jan 1 1991, In : Antimicrobial Agents and Chemotherapy. 35, 2, p. 377-379 3 p.

Research output: Contribution to journalArticle

Open Access
Pneumocystis carinii
Alkaloids
Primaquine
Rutaceae
Chloroquine
12 Citations (Scopus)

In Vitro Release of Endogenous Dopamine from the Striatum of the Weaver Mutant Mouse

Simon, J. R., Yu, H., Richter, J. A., Vasko, M. R. & Ghetti, B., Nov 1991, In : Journal of Neurochemistry. 57, 5, p. 1478-1482 5 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopamine
Corpus Striatum
Amphetamine
Potassium
8 Citations (Scopus)

Isolation and characterization of rat lung Pneumocystis carinii gp120.

Paulsrud, J. R., Queener, S. F., Bartlett, M. S. & Smith, J. W., Jan 1 1991, In : The Journal of Protozoology. 38, 6, p. 10S-11S

Research output: Contribution to journalArticle

Pneumocystis carinii
Lung
Peptides
Glycoproteins
Cyanogen Bromide
71 Citations (Scopus)

Modulation of ATP and drug binding by monoclonal antibodies against P‐glycoprotein

Georges, E., Zhang, JT. T. & Ling, V., Sep 1991, In : Journal of cellular physiology. 148, 3, p. 479-484 6 p.

Research output: Contribution to journalArticle

Adenosine Triphosphate
Monoclonal Antibodies
Modulation
Pharmaceutical Preparations
Molecules
101 Citations (Scopus)

Pneumocystis carinii dihydrofolate reductase used to screen potential antipneumocystis drugs

Broughton, M. C. & Queener, S. F., Jan 1 1991, In : Antimicrobial Agents and Chemotherapy. 35, 7, p. 1348-1355 8 p.

Research output: Contribution to journalArticle

Open Access
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Trimetrexate
Trimethoprim
Pharmaceutical Preparations
105 Citations (Scopus)

Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation

Zhang, J. T. & Ling, V., Nov 8 1991, In : Journal of Biological Chemistry. 266, 27, p. 18224-18232 9 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Membranes
Signal Recognition Particle
Topology
Glycosylation
2 Citations (Scopus)

The effect of primaquine on the ultrastructural morphology of Pneumocystis carinii.

Goheen, M. P., Bartlett, M. S., Queener, S. F. & Smith, J. W., Jan 1 1991, In : The Journal of Protozoology. 38, 6, p. 164S-165S

Research output: Contribution to journalArticle

Primaquine
Pneumocystis carinii
Pneumocystis
Fibroblasts
Lung
101 Citations (Scopus)

Tissue-Specific Distribution of Differentially Phosphorylated Forms of Cx43

Kadle, R., Zhang, J. T. & Nicholson, B. J., Jan 1991, In : Molecular and cellular biology. 11, 1, p. 363-369 7 p.

Research output: Contribution to journalArticle

Open Access
Connexin 43
Tissue Distribution
RNA
Crystallins
Connexins
30 Citations (Scopus)

Voltage-dependent gating and block of the cyclic-GMP-dependent current in bovine rod outer segments

Quandt, F. N., Nicol, G. D. & Schnetkamp, P. P. M., 1991, In : Neuroscience. 42, 3, p. 629-638 10 p.

Research output: Contribution to journalArticle

Rod Cell Outer Segment
Cyclic GMP
Diltiazem
Tetracaine
Divalent Cations
1992
6 Citations (Scopus)
Gophers
Sciuridae
Mitochondria
Liver Mitochondrion
Oxidative Phosphorylation
5 Citations (Scopus)

An enzyme-linked immunosorbent assay for enumeration of Pneumocystis carinii in vitro and in vivo

Durkin, M. M., Bartlett, M. S., Queener, S. F., Shaw, M. M., Lee, C. H. & Smith, J. W., Jan 1 1992, In : Journal of clinical microbiology. 30, 12, p. 3258-3262 5 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Enzyme-Linked Immunosorbent Assay
Antibodies
Lung
In Vitro Techniques
30 Citations (Scopus)

Antimicrotubule benzimidazoles inhibit in vitro growth of Pneumocystis carinii

Bartlett, M. S., Edlind, T. D., Durkin, M. M., Shaw, M. M., Queener, S. F. & Smith, J. W., Jan 1 1992, In : Antimicrobial Agents and Chemotherapy. 36, 4, p. 779-782 4 p.

Research output: Contribution to journalArticle

Open Access
Benzimidazoles
Pneumocystis carinii
Thiabendazole
Structure-Activity Relationship
Growth
3 Citations (Scopus)

Biotransformation in Carcinogen-induced Separated by Centrifugal Elutriation

Watkins, J. B., Thierau, D. & Schwarz, L. R., Mar 1992, In : Cancer Research. 52, 5, p. 1149-1154 6 p.

Research output: Contribution to journalArticle

Biotransformation
Carcinogens
Hepatocytes
Diploidy
Polyploidy
13 Citations (Scopus)

Chronic physical activity: Hepatic hypertrophy and increased total biotransformation enzyme activity

Yiamouyiannis, C. A., Sanders, R. A., Watkins, J. B. & Martin, B. J., Jul 7 1992, In : Biochemical Pharmacology. 44, 1, p. 121-127 7 p.

Research output: Contribution to journalArticle

Enzyme activity
Biotransformation
Liver
Hypertrophy
Rats
16 Citations (Scopus)

Differential responses of Ca-activated K channels to bradykinin in sensory neurons and F-11 cells

Naruse, K., McGehee, D. S. & Oxford, G. S., Apr 6 1992, In : American Journal of Physiology - Cell Physiology. 262, 2 31-2, p. C453-C460

Research output: Contribution to journalArticle

Spinal Ganglia
Bradykinin
Sensory Receptor Cells
Neurons
Chemical activation
212 Citations (Scopus)

Dopaminergic Modulation of Glutamate Release in Striatum as Measured by Microdialysis

Yamamoto, B. K. & Davy, S., May 1992, In : Journal of Neurochemistry. 58, 5, p. 1736-1742 7 p.

Research output: Contribution to journalArticle

Microdialysis
Glutamic Acid
Modulation
Aspartic Acid
Taurine
18 Citations (Scopus)

Efficacy of Intermittent Dosage of 8-Aminoquinolines for Therapy or Prophylaxis of Pneumocystis Pneumonia in Rats

Queener, S. F., Dean, R. A., Bartlett, M. S., Milhous, W. K., Berman, J. D., Ellis, W. Y. & Smith, J. W., Apr 1 1992, In : Journal of Infectious Diseases. 165, 4, p. 764-768 5 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Primaquine
Therapeutics
Sulfamethoxazole Drug Combination Trimethoprim
8-aminoquinoline
23 Citations (Scopus)

Inoculated mouse model of Pneumocystis carinii infection

Bartlett, M. S., Queener, S. F., Durkin, M. M., Shaw, M. A. & Smith, J. W., Feb 1992, In : Diagnostic Microbiology and Infectious Disease. 15, 2, p. 129-134 6 p.

Research output: Contribution to journalArticle

Pneumocystis Infections
Pneumocystis
Pneumocystis carinii
Sulfamethoxazole Drug Combination Trimethoprim
Costs and Cost Analysis
64 Citations (Scopus)

Involvement of the nitric oxide-cyclic GMP pathway in the desensitization of bradykinin responses of cultured rat sensory neurons

McGehee, D. S., Goy, M. F. & Oxford, G. S., Aug 1992, In : Neuron. 9, 2, p. 315-324 10 p.

Research output: Contribution to journalArticle

Cyclic GMP
Bradykinin
Sensory Receptor Cells
Nitric Oxide Synthase
Nitric Oxide
95 Citations (Scopus)

Liposome-mediated modulation of multidrug resistance in human HL-60 leukemia cells

Rahman, A., Husain, S. R., Siddiqui, J., Verma, M., Agresti, M., Center, M., Safa, A. R. & Glazer, R. I., Dec 16 1992, In : Journal of the National Cancer Institute. 84, 24, p. 1909-1915 7 p.

Research output: Contribution to journalArticle

HL-60 Cells
Multiple Drug Resistance
Liposomes
Doxorubicin
Leukemia
46 Citations (Scopus)

Long-term diabetes alters the hepatobiliary clearance of acetaminophen, bilirubin and digoxin

Watkins, J. B. & Sherman, S. E., Jan 1 1992, In : Journal of Pharmacology and Experimental Therapeutics. 260, 3, p. 1337-1343 7 p.

Research output: Contribution to journalArticle

Digoxin
Acetaminophen
Bilirubin
Insulin
Half-Life
56 Citations (Scopus)

Megestrol acetate reverses multidrug resistance and interacts with P-glycoprotein

Fleming, G. F., Amato, J. M., Agresti, M. & Safa, A. R., Nov 1 1992, In : Cancer Chemotherapy and Pharmacology. 29, 6, p. 445-449 5 p.

Research output: Contribution to journalArticle

Megestrol Acetate
Multiple Drug Resistance
P-Glycoprotein
Vincristine
Progesterone
270 Citations (Scopus)

Methamphetamine neurotoxicity and striatal glutamate release: comparison to 3,4-methylenedioxymethamphetamine

Nash, J. F. & Yamamoto, B. K., May 29 1992, In : Brain research. 581, 2, p. 237-243 7 p.

Research output: Contribution to journalArticle

Corpus Striatum
N-Methyl-3,4-methylenedioxyamphetamine
Methamphetamine
Glutamic Acid
Dopamine
143 Citations (Scopus)

Modulation of P-glycoprotein-mediated drug transport by alterations in lipid fluidity of rat liver canalicular membrane vesicles

Sinicrope, F. A., Dudeja, P. K., Bissonnette, B. M., Safa, A. R. & Brasitus, T. A., Jan 1 1992, In : Journal of Biological Chemistry. 267, 35, p. 24995-25002 8 p.

Research output: Contribution to journalArticle

Fluidity
P-Glycoprotein
Liver
Rats
Daunorubicin
Neuropeptides
Cysteine
Neurotransmitter Agents
Rats
dynorphin (1-8)
46 Citations (Scopus)

Photoaffinity labeling of p-glycoprotein in multidrug-resistant cells: New drugs

Safa, A. R., Jan 1 1992, In : Cancer Investigation. 10, 4, p. 295-305 11 p.

Research output: Contribution to journalArticle

Glycoproteins
Pharmaceutical Preparations
173 Citations (Scopus)

Prostaglandin E2 increases calcium conductance and stimulates release of substance P in avian sensory neurons

Nicol, G. D., Klingberg, D. K. & Vasko, M. R., Jan 1 1992, In : Journal of Neuroscience. 12, 5, p. 1917-1927 11 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Substance P
Dinoprostone
Calcium
Prostaglandins
7 Citations (Scopus)
Gophers
Mitochondria
Liver Mitochondrion
Phospholipases A2
Liver
11 Citations (Scopus)

Selective subregional dopamine depletions in the rat caudate‐putamen following nigrostriatal lesions

Pehek, E. A., Crock, R. & Yamamoto, B. K., Apr 1992, In : Synapse. 10, 4, p. 317-325 9 p.

Research output: Contribution to journalArticle

Dopamine
Substantia Nigra
Corpus Striatum
Injections
Dopaminergic Neurons
27 Citations (Scopus)
Neurokinin-1 Receptors
Tachykinins
Capsaicin
Spinal Ganglia
Basal Ganglia
16 Citations (Scopus)
Corpus Striatum
Antipsychotic Agents
Dopamine
Amphetamine
Dopamine Plasma Membrane Transport Proteins
32 Citations (Scopus)

Thermoregulatory, carboxyatractylate-sensitive uncoupling in heart and skeletal muscle mitochondria of the ground squirrel correlates with the level of free fatty acids

Brustovetsky, N. N., Egorova, M. V., Gnutov, D. Y., Gogvadze, V. G., Mokhova, E. N. & Skulachev, V. P., Jun 22 1992, In : FEBS Letters. 305, 1, p. 15-17 3 p.

Research output: Contribution to journalArticle

Muscle Mitochondrion
Sciuridae
Mitochondria
Nonesterified Fatty Acids
Muscle
12 Citations (Scopus)
Vecuronium Bromide
Taurocholic Acid
Polyploidy
Ouabain
Diploidy
1993
68 Citations (Scopus)

2,4-Diaminothieno[2,3-d]pyrimidine Analogues of Trimetrexate and Piritrexim as Potential Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase

Rosowsky, A., Mota, C. E., Wright, J. E., Freisheim, J. H., Heusner, J. J., McCormack, J. J. & Queener, S. F., Jan 1 1993, In : Journal of Medicinal Chemistry. 36, 21, p. 3103-3112 10 p.

Research output: Contribution to journalArticle

Trimetrexate
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
Folic Acid Antagonists
30 Citations (Scopus)

8-Aminoquinolines effective against Pneumocystis carinii in vitro and in vivo

Queener, S. F., Bartlett, M. S., Nasr, M. & Smith, J. W., Jan 1 1993, In : Antimicrobial Agents and Chemotherapy. 37, 10, p. 2166-2172 7 p.

Research output: Contribution to journalArticle

Open Access
Primaquine
Pneumocystis carinii
Pneumocystis Pneumonia
Drinking Water
Nitrogen
26 Citations (Scopus)

Alcohol‐Induced Inhibition of Alveolar Macrophage Oxidant Release in Vivo and in Vitro

Antony, V. B., Godbey, S. W., Hott, J. W. & Queener, S. F., Apr 1993, In : Alcoholism: Clinical and Experimental Research. 17, 2, p. 389-393 5 p.

Research output: Contribution to journalArticle

Alveolar Macrophages
Oxidants
Alcohols
Superoxides
Rats
58 Citations (Scopus)

Amylin modulates β-cell glucose sensing via effects on stimulus-secretion coupling

Wagoner, P. K., Chen, C., Worley, J. F., Dukes, I. D. & Oxford, G. S., Oct 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 19, p. 9145-9149 5 p.

Research output: Contribution to journalArticle

Open Access
Islet Amyloid Polypeptide
Glucose
Insulin
Pancreas
Peptides
7 Citations (Scopus)
Dopamine
Electrodes
Corpus Striatum
Dextroamphetamine
In Vitro Techniques
3 Citations (Scopus)
Folic Acid Antagonists
Molecular Conformation
Pneumocystis carinii
Pyrimidines
Toxoplasma
19 Citations (Scopus)

Chronic physical activity alters hepatobiliary excretory function in rats

Yiamouyiannis, C. A., Martin, B. J. & Watkins, J. B., Jan 1 1993, In : Journal of Pharmacology and Experimental Therapeutics. 265, 1, p. 321-327 7 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Anions
Cations
Antipyrine
Aminopyrine
21 Citations (Scopus)

Cyclosporin A suppression of uncoupling in liver mitochondria of ground squirrel during arousal from hibernation

Brustovetsky, N. N., Egorova, M. V., Gnutov, D. Y., Mokhova, E. N. & Skulachev, V. P., Jan 11 1993, In : FEBS Letters. 315, 3, p. 233-236 4 p.

Research output: Contribution to journalArticle

Hibernation
Sciuridae
Mitochondria
Liver Mitochondrion
Arousal
75 Citations (Scopus)

Differential expression of P‐glycoprotein genes in primary rat hepatocyte culture

Lee, C. H., Bradley, G., Zhang, JT. T. & Ling, V., Nov 1993, In : Journal of cellular physiology. 157, 2, p. 392-402 11 p.

Research output: Contribution to journalArticle

Cell culture
MHC Class II Genes
Rats
Hepatocytes
Genes
53 Citations (Scopus)

Effect of D-amphetamine on the extracellular concentrations of glutamate and dopamine in iprindole-treated rats

Frank Nash, J. & Yamamoto, B. K., Nov 5 1993, In : Brain research. 627, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Iprindole
Amphetamine
Dextroamphetamine
Glutamic Acid
Dopamine
3 Citations (Scopus)

Effect of sodium orthovanadate on the hepatobiliary clearance of rose bengal in streptozotocin-induced diabetic rats

Watkins, J. B., Bauman, M. E. & Beaty, T. M., Dec 14 1993, In : Biochemical Pharmacology. 46, 12, p. 2269-2276 8 p.

Research output: Contribution to journalArticle

Rose Bengal
Vanadates
Streptozocin
Rats
Sodium
8 Citations (Scopus)

Effects of 8-aminoquinolines on the ultrastructural morphology of Pneumocystis carinii

Goheen, M. P., Bartlett, M. S., Shaw, M. M., Queener, S. F. & Smith, J. W., Aug 31 1993, In : International Journal of Experimental Pathology. 74, 4, p. 379-387 9 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Primaquine
Trophozoites
Nuclear Envelope
8-aminoquinoline
36 Citations (Scopus)

Extracellular glutamate levels increase with age in the lateral striatum: Potential involvement of presynaptic D‐2 receptors

Donzanti, B. A., Hite, J. F. & Yamamoto, B. K., Apr 1993, In : Synapse. 13, 4, p. 376-382 7 p.

Research output: Contribution to journalArticle

Presynaptic Receptors
Glutamic Acid
quinelorane
Corpus Striatum
Sulpiride
88 Citations (Scopus)

Functional Analysis of P-Glycoprotein Mutants Identifies Predicted Transmembrane Domain 11 as a Putative Drug Binding Site

Kajiji, S., Talbot, F., Grizzuti, K., Van Dyke-Phillips, V., Agresti, M., Safa, A. R. & Gros, P., Apr 1 1993, In : Biochemistry. 32, 16, p. 4185-4194 10 p.

Research output: Contribution to journalArticle

Functional analysis
P-Glycoprotein
Binding Sites
P-Glycoproteins
Doxorubicin
121 Citations (Scopus)

Functional consequences of a Na+ channel mutation causing hyperkalemic periodic paralysis

Cummins, T. R., Zhou, J., Sigworth, F. J., Ukomadu, C., Stephan, M., Ptáčk, L. J. & Agnew, W. S., Apr 1993, In : Neuron. 10, 4, p. 667-678 12 p.

Research output: Contribution to journalArticle

Hyperkalemic Periodic Paralysis
Mutation
Muscles
Inborn Genetic Diseases
Pedigree