Pharmacology & Toxicology

Publications 1971 2020

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21 Citations (Scopus)

Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins

Xiao, Y., Blumenthal, K. & Cummins, T., 2014, In : Molecular Pharmacology. 86, 2, p. 159-167 9 p.

Research output: Contribution to journalArticle

Biological Toxins
Sodium Channels
Sea Anemones
Voltage-Gated Sodium Channels
Ion Channels
24 Citations (Scopus)

GBR-12909-induced self-injurious behavior: role of dopamine

Sivam, S., Sep 4 1995, In : Brain Research. 690, 2, p. 259-263 5 p.

Research output: Contribution to journalArticle

Self-Injurious Behavior
Dopamine
Oxidopamine
Corpus Striatum
Spiperone
14 Citations (Scopus)

GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii

Konrad, C., Wek, R. & Sullivan, W., Feb 2014, In : International Journal for Parasitology. 44, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Eukaryotic Initiation Factors
Toxoplasma
Starvation
Parasites
50 Citations (Scopus)

Genetic pathways, prevention, and treatment of sporadic colorectal cancer

Mundade, R., Imperiale, T. F., Prabhu, L., Loehrer, P. J. & Lu, T., 2014, In : Oncoscience. 1, 6, p. 400-406 7 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Epigenomics
Colonic Neoplasms
Therapeutics
Neoplasms
63 Citations (Scopus)

Global microRNA expression profiling of caenorhabditis elegans Parkinson's disease models

Asikainen, S., Rudgalvyte, M., Heikkinen, L., Louhiranta, K., Lakso, M., Wong, G. & Nass, R., May 2010, In : Journal of Molecular Neuroscience. 41, 1, p. 210-218 9 p.

Research output: Contribution to journalArticle

Synucleins
Caenorhabditis elegans
MicroRNAs
Parkinson Disease
Cats
12 Citations (Scopus)

Glucose-independent acetate metabolism promotes melanoma cell survival and tumor growth

Lakhter, A. J., Hamilton, J., Konger, R., Broustovetski, N., Broxmeyer, H. & Naidu, S., Oct 14 2016, In : Journal of Biological Chemistry. 291, 42, p. 21869-21879 11 p.

Research output: Contribution to journalArticle

Metabolism
Tumors
Melanoma
Cell Survival
Acetates

Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding

Reilly, A. M., Zhou, S., Panigrahi, S. K., Yan, S., Conley, J. M., Sheets, P. L., Wardlaw, S. L. & Ren, H., Dec 1 2019, In : Nutrition and Diabetes. 9, 1, 29.

Research output: Contribution to journalArticle

Open Access
Pro-Opiomelanocortin
High Fat Diet
Neurons
Knockout Mice
Homeostasis
1 Citation (Scopus)

G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans

Wang, J., Luo, J., Aryal, D. K., Wetsel, W. C., Nass, R. & Benovic, J. L., Apr 7 2017, In : Journal of Biological Chemistry. 292, 14, p. 5943-5956 14 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinase 2
Monoamine Oxidase
Caenorhabditis elegans
Metabolism
Serotonin
17 Citations (Scopus)

Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis

Benmerzouga, I., Checkley, L. A., Ferdig, M. T., Arrizabalaga, G., Wek, R. & Sullivan, W., Nov 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6939-6945 7 p.

Research output: Contribution to journalArticle

Guanabenz
Antiparasitic Agents
Toxoplasmosis
Toxoplasma
Cysts
2 Citations (Scopus)

Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation

Martynowicz, J., Augusto, L., Wek, R., Boehm, S. L. & Sullivan, W., Apr 30 2019, In : mBio. 10, 2

Research output: Contribution to journalArticle

Open Access
Guanabenz
Toxoplasmosis
Cysts
Parasites
Toxoplasma

Hedgehog pathway activation alters ciliary signaling in primary hypothalamic cultures

Bansal, R., Engle, S. E., Antonellis, P. J., Whitehouse, L. S., Baucum, A. J., Cummins, T., Reiter, J. F. & Berbari, N. F., May 14 2019, In : Frontiers in Cellular Neuroscience. 13, 266.

Research output: Contribution to journalArticle

Open Access
Hedgehogs
Cilia
Neurons
Hyperphagia
Feeding Behavior
5 Citations (Scopus)
Inbred WKY Rats
Streptozocin
Biotransformation
Sprague Dawley Rats
Sulfobromophthalein
3 Citations (Scopus)

Hepatic phase II biotransformation in C57Bl/KsJ db/db mice: comparison to that in swiss webster and 129 REJ mice

Watkins, J. B. & klueber, K. M., 1988, In : Comparative Biochemistry and Physiology. Part C: Comparative. 90, 2, p. 417-421 5 p.

Research output: Contribution to journalArticle

129 Strain Mouse
Biotransformation
Liver
Ethacrynic Acid
Dinitrochlorobenzene
15 Citations (Scopus)

Hepatobiliary excretion of bile acids and rose bengal in streptozotocin- induced and genetic diabetic rats

Stone, J. L., Braunstein, J. B., Beaty, T. M., Sanders, R. A. & Watkins, J. B., 1997, In : Journal of Pharmacology and Experimental Therapeutics. 281, 1, p. 412-419 8 p.

Research output: Contribution to journalArticle

Rose Bengal
Streptozocin
Bile Acids and Salts
Bile
Wistar Rats
1 Citation (Scopus)

Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury

Omar, H. M., Sanders, R. A. & Watkins, J. B., 1996, In : Inflammation Research. 45, 10, p. 519-523 5 p.

Research output: Contribution to journalArticle

Leukotriene C4
Leukotrienes
Theoretical Models
Liver
Wounds and Injuries
15 Citations (Scopus)

Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala

Ferreira, A. N., Yousuf, H., Dalton, S. & Sheets, P., Apr 28 2015, In : Frontiers in Cellular Neuroscience. 9, APR, 161.

Research output: Contribution to journalArticle

Periaqueductal Gray
Pyramidal Cells
Amygdala
Neurons
Fear
32 Citations (Scopus)

Histone acetylase GCN5 enters the nucleus via importin-α in protozoan parasite Toxoplasma gondii

Bhatti, M. M. & Sullivan, W., Feb 18 2005, In : Journal of Biological Chemistry. 280, 7, p. 5902-5908 7 p.

Research output: Contribution to journalArticle

Karyopherins
Histone Acetyltransferases
Toxoplasma
Nuclear Localization Signals
Parasites
15 Citations (Scopus)
Toxoplasma
Pathogens
Plasmodium falciparum
Histones
Parasites
45 Citations (Scopus)

Histone mediated gene activation in Toxoplasma gondii

Sullivan, W. & Hakimi, M. A., Aug 2006, In : Molecular and Biochemical Parasitology. 148, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

Toxoplasma
Histones
Transcriptional Activation
Parasites
Histone Code
121 Citations (Scopus)

Histone-modifying complexes regulate gene expression pertinent to the differentiation of the protozoan parasite Toxoplasma gondii

Saksouk, N., Bhatti, M. M., Kieffer, S., Smith, A. T., Musset, K., Garin, J., Sullivan, W., Cesbron-Delauw, M. F. & Hakimi, M. A., Dec 2005, In : Molecular and Cellular Biology. 25, 23, p. 10301-10314 14 p.

Research output: Contribution to journalArticle

Toxoplasma
Histones
Parasites
Gene Expression
Histone Deacetylases
59 Citations (Scopus)

Histones and histone modifications in protozoan parasites

Sullivan, W., Naguleswaran, A. & Angel, S. O., Dec 2006, In : Cellular Microbiology. 8, 12, p. 1850-1861 12 p.

Research output: Contribution to journalArticle

Histone Code
Histones
Parasites
Eukaryota
Chromatin
10 Citations (Scopus)

HIV and drug abuse mediate astrocyte senescence in a β-catenin-dependent manner leading to neuronal toxicity

Yu, C., Narasipura, S. D., Richards, M. H., Hu, X. T., Yamamoto, B. & Al-Harthi, L., 2017, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Catenins
Astrocytes
Substance-Related Disorders
Methamphetamine
HIV
9 Citations (Scopus)

Human ABCC1 interacts and colocalizes with ATP synthase α, revealed by interactive proteomics analysis

Yang, Y., Li, Z., Mo, W., Ambadipudi, R., Arnold, R. J., Hrncirova, P., Novotny, M. V., Georges, E. & Zhang, J-T., Feb 3 2012, In : Journal of Proteome Research. 11, 2, p. 1364-1372 9 p.

Research output: Contribution to journalArticle

Proteomics
Adenosine Triphosphate
Phosphorylation
ATP-Binding Cassette Transporters
Multiple Drug Resistance
124 Citations (Scopus)

Human ABCG2: Structure, function, and its role in multidrug resistance

Mo, W. & Zhang, J-T., 2012, In : International Journal of Biochemistry and Molecular Biology. 3, 1, p. 1-27 27 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Multiple Drug Resistance
Chemotherapy
Neoplastic Stem Cells
Endocytosis
46 Citations (Scopus)

Human DNA polymerase η activity and translocation is regulated by phosphorylation

Chen, Y. W., Cleaver, J. E., Hatahet, Z., Honkanen, R. E., Chang, J. Y., Yen, Y. & Chou, K. M., Oct 28 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16578-16583 6 p.

Research output: Contribution to journalArticle

gemcitabine
DNA-Directed DNA Polymerase
Phosphorylation
Cisplatin
Protein Interaction Domains and Motifs
33 Citations (Scopus)

Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy

Xu, J., Peng, H. & Zhang, J-T., Mar 2007, In : Current Medicinal Chemistry. 14, 6, p. 689-701 13 p.

Research output: Contribution to journalArticle

Chemotherapy
Drug Resistance
Drug Therapy
Multiple Drug Resistance
Pharmaceutical Preparations
11 Citations (Scopus)

Human Nav1.6 channels generate larger resurgent currents than human Nav1.1 channels, but the Navβ4 peptide does not protect either isoform from use-dependent reduction

Patel, R. R., Barbosa, C., Xiao, Y. & Cummins, T., Jul 16 2015, In : PLoS One. 10, 7, e0133485.

Research output: Contribution to journalArticle

action potentials
inactivation
Protein Isoforms
GABAergic Neurons
Action Potentials
89 Citations (Scopus)

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

Jarecki, B. W., Piekarz, A. D., Jackson, J. O. & Cummins, T., Jan 4 2010, In : Journal of Clinical Investigation. 120, 1, p. 369-378 10 p.

Research output: Contribution to journalArticle

Channelopathies
Voltage-Gated Sodium Channels
Sodium
Muscles
Mutation
17 Citations (Scopus)
beta-galactoside alpha-2,3-sialyltransferase
Sialyltransferases
Galactosides
Caspase 8
Paclitaxel
11 Citations (Scopus)

Hypertension incidence after tap-water implementation: A 13-year follow-up study in the arseniasis-endemic area of southwestern Taiwan

Wang, S. L., Li, W. F., Chen, C. J., Huang, Y. L., Chen, J. W., Chang, K. H., Tsai, L. Y. & Chou, K. M., Oct 1 2011, In : Science of the Total Environment. 409, 21, p. 4528-4535 8 p.

Research output: Contribution to journalArticle

hypertension
Arsenic
artesian well
arsenic
well water
20 Citations (Scopus)
DNA-(Apurinic or Apyrimidinic Site) Lyase
Peripheral Nervous System Diseases
oxaliplatin
Drug Therapy
Sensory Receptor Cells
76 Citations (Scopus)
Multiple Drug Resistance
P-Glycoprotein
Binding Sites
Pharmaceutical Preparations
Carrier Proteins
46 Citations (Scopus)
Videocassette recorders
HL-60 Cells
Myeloid Cells
Acute Myeloid Leukemia
Luciferases
88 Citations (Scopus)

Identification of 14-3-3σ as a contributor to drug resistance in human breast cancer cells using functional proteomic analysis

Liu, Y., Liu, H., Han, B. & Zhang, J-T., Mar 15 2006, In : Cancer Research. 66, 6, p. 3248-3255 8 p.

Research output: Contribution to journalArticle

MCF-7 Cells
Drug Resistance
Proteomics
Breast Neoplasms
Multiple Drug Resistance
82 Citations (Scopus)

Identification of a 170-kDa protein over-expressed in lung cancers

Pincheira, R., Chen, Q. & Zhang, J-T., Jun 1 2001, In : British Journal of Cancer. 84, 11, p. 1520-1527 8 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Peptide Initiation Factors
Proteins
Growth and Development
Early Detection of Cancer
30 Citations (Scopus)
Dihydropteroate Synthase
Sulfamethoxazole
Pneumocystis carinii
Mycobacterium avium
Sulfonamides
92 Citations (Scopus)

Identification of highly potent and selective inhibitors of Toxoplasma gondii dihydrofolate reductase

Chio, L. C. & Queener, S., 1993, In : Antimicrobial Agents and Chemotherapy. 37, 9, p. 1914-1923 10 p.

Research output: Contribution to journalArticle

Pyrimethamine
Tetrahydrofolate Dehydrogenase
Toxoplasma
Trimetrexate
Inhibitory Concentration 50
21 Citations (Scopus)

Identification of novel small molecule inhibitors of the XPA protein using in silico based screening

Neher, T. M., Shuck, S. C., Liu, J. Y., Zhang, J-T. & Turchi, J., Oct 15 2010, In : ACS Chemical Biology. 5, 10, p. 953-965 13 p.

Research output: Contribution to journalArticle

Xeroderma Pigmentosum Group A Protein
Computer Simulation
Screening
Molecules
DNA
9 Citations (Scopus)

Identification of proteins interacting with Toxoplasma SRCAP by yeast two-hybrid screening

Nallani, K. C. & Sullivan, W., Mar 2005, In : Parasitology Research. 95, 4, p. 236-242 7 p.

Research output: Contribution to journalArticle

two hybrid system techniques
Toxoplasma
Toxoplasma gondii
Yeasts
yeasts
8 Citations (Scopus)

Identification of the benzyloxyphenyl pharmacophore: A structural unit that promotes sodium channel slow inactivation

King, A. M., Yang, X. F., Wang, Y., Dustrude, E. T., Barbosa, C., Due, M. R., Piekarz, A. D., Wilson, S. M., White, F., Salomé, C., Cummins, T., Khanna, R. & Kohn, H., Dec 19 2012, In : ACS Chemical Neuroscience. 3, 12, p. 1037-1049 13 p.

Research output: Contribution to journalArticle

Electrophysiology
Stereoselectivity
Acetylation
Sodium Channels
Clamping devices

Identification of vimentin as a primaquine-binding protein from pneumocystis cakinii

Queener, S. & Bolvard, L. A., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

Pneumocystis
Primaquine
vimentin
Vimentin
binding proteins
17 Citations (Scopus)

Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons

Brittain, M. K., Brustovetsky, T., Brittain, J. M., Khanna, R., Cummins, T. & Broustovetski, N., Nov 2012, In : Neuropharmacology. 63, 6, p. 974-982 9 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
N-Methylaspartate
Calcium
Neurons
Glutamate Receptors
39 Citations (Scopus)

Imbalance in ornithine metabolism in hepatomas of different growth rates as expressed in behavior of L-ornithine carbamyl transferase activity.

Weber, G., Queener, S. & Morris, H. P., Sep 1972, In : Cancer Research. 32, 9, p. 1933-1940 8 p.

Research output: Contribution to journalArticle

Experimental Neoplasms
Ornithine Carbamoyltransferase
Inbred Strains Rats
Liver Regeneration
Ornithine
30 Citations (Scopus)

IMP dehydrogenase from Pneumocystis carinii as a potential drug target

O'Gara, M. J., Lee, C-H., Weinberg, G. A., Nott, J. M. & Queener, S., Jan 1997, In : Antimicrobial Agents and Chemotherapy. 41, 1, p. 40-48 9 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Pneumocystis carinii
Pharmaceutical Preparations
Mycophenolic Acid
Escherichia coli
28 Citations (Scopus)

IMP dehydrogenase from the protozoan parasite Toxoplasma gondii

Sullivan, W., Dixon, S. E., Li, C., Striepen, B. & Queener, S., Jun 2005, In : Antimicrobial Agents and Chemotherapy. 49, 6, p. 2172-2179 8 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Toxoplasma
Parasites
Mycophenolic Acid
Inosine Monophosphate
86 Citations (Scopus)

Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons

Jiang, Y., Guo, C., Vasko, M. & Kelley, M., Aug 1 2008, In : Cancer Research. 68, 15, p. 6425-6434 10 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Spinal Ganglia
Cisplatin
Oxygen
Neurons
18 Citations (Scopus)

Improved rat model for studying Pneumocystis carinii pneumonia

Bartlett, M. S., Queener, S., Jay, M. A., Durkin, M. M. & Smith, J. W., 1987, In : Journal of Clinical Microbiology. 25, 3, p. 480-484 5 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Pneumocystis Infections
T-Lymphocytes
Immunosuppression
Hydrocortisone
2 Citations (Scopus)

Inclusion of a competency-based curriculum in medical pharmacology

Near, J. A., Bosin, T. R. & Watkins, J. B., 2002, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 366, 1, p. 26-29 4 p.

Research output: Contribution to journalArticle

Curriculum
Pharmacology
Students
Educational Models
Foster Home Care
17 Citations (Scopus)

Incorporation of fatty acids and amino acids by cultured Pneumocystis carinii

Paulsrud, J. R. & Queener, S., Nov 1994, In : Journal of Eukaryotic Microbiology. 41, 6, p. 633-638 6 p.

Research output: Contribution to journalArticle

Biological Transport
Primaquine
Pneumocystis carinii
Fungal Proteins
Membrane Glycoproteins
18 Citations (Scopus)
Multidrug Resistance-Associated Proteins
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Messenger RNA
Acute Myeloid Leukemia
Biphenotypic Acute Leukemia