Pharmacology & Toxicology

Publications 1970 2020

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9 Citations (Scopus)
Phosphorylation
Cell death
Islets of Langerhans
Cell Death
Chemical activation
18 Citations (Scopus)

Cytoplasmic retraction of the amino terminus of human multidrug resistance protein 1

Chen, Q., Yang, Y., Liu, Y., Han, B. & Zhang, J. T., Jul 23 2002, In : Biochemistry. 41, 29, p. 9052-9062 11 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Epitopes
MDR Genes
Multiple Drug Resistance
Indirect Fluorescent Antibody Technique
36 Citations (Scopus)
Self-Injurious Behavior
Dopamine D1 Receptors
Denervation
Substance P
Oxidopamine
65 Citations (Scopus)

D2 dopamine receptor activation of potassium channels in identified rat lactotrophs: Whole-cell and single-channel recording

Einhorn, L. C., Gregerson, K. A. & Oxford, G. S., Dec 1 1991, In : Journal of Neuroscience. 11, 12, p. 3727-3737 11 p.

Research output: Contribution to journalArticle

Lactotrophs
Dopamine D2 Receptors
Potassium Channels
Dopamine
Quinine
44 Citations (Scopus)

D2 dopamine receptor activation of potassium channels is selectively decoupled by Gαi-specific GoLoco motif peptides

Webb, C. K., McCudden, C. R., Willard, F. S., Kimple, R. J., Siderovski, D. P. & Oxford, G. S., Mar 1 2005, In : Journal of Neurochemistry. 92, 6, p. 1408-1418 11 p.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Potassium Channels
Chemical activation
Peptides
GTP-Binding Proteins
41 Citations (Scopus)

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

Juang, S. H., Lung, C. C., Hsu, P. C., Hsu, K. S., Li, Y. C., Hong, P. C., Shiah, H. S., Kuo, C. C., Huang, C. W., Wang, Y. C., Huang, L., Chen, T. S., Chen, S. F., Fu, K. C., Hsu, C. L., Lin, M. J., Chang, C. J., Ashendel, C. L., Chan, T. C. K., Chou, K. M. & 1 others, Chang, J. C., Jan 1 2007, In : Molecular cancer therapeutics. 6, 1, p. 193-202 10 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia Mutated Proteins
Nuclear Proteins
Protein Kinases
DNA Damage
DNA Breaks
31 Citations (Scopus)

Decreased apoptosis as a mechanism for hepatomegaly in streptozotocin- induced diabetic rats

Herrman, C. E., Sanders, R. A., Klaunig, J. E., Schwarz, L. R. & Watkins, J. B., Aug 2 1999, In : Toxicological Sciences. 50, 1, p. 146-151 6 p.

Research output: Contribution to journalArticle

Hepatomegaly
Streptozocin
Rats
Medical problems
Liver
21 Citations (Scopus)

Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchanger

Brittain, M. K., Brustovetsky, T., Sheets, P. L., Brittain, J. M., Khanna, R., Cummins, T. R. & Brustovetsky, N., Apr 1 2012, In : Neurobiology of Disease. 46, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Calcium
Neurons
Memantine
Glutamic Acid
3 Citations (Scopus)

Deletion of mitochondrial calcium uniporter incompletely inhibits calcium uptake and induction of the permeability transition pore in brain mitochondria

Hamilton, J., Brustovetsky, T., Rysted, J. E., Lin, Z., Usachev, Y. M. & Broustovetski, N., Jan 1 2018, In : Journal of Biological Chemistry. 293, 40, p. 15652-15663 12 p.

Research output: Contribution to journalArticle

Mitochondria
Permeability
Brain
Calcium
mitochondrial calcium uniporter

Demonstration of esterase activity in Pneumocystis carinii by cleavage of 4-methylumbelliferyl substrates

Durant, P. J., Bartlett, M. S., Shaw, M. M., Queener, S. F. & Smith, J. W., Sep 1 1996, In : Journal of Eukaryotic Microbiology. 43, 5, p. 45S

Research output: Contribution to journalArticle

Hymecromone
Pneumocystis
Pneumocystis carinii
Esterases
Cell Line
3 Citations (Scopus)

Demonstration that cyclic adenosine 3',5' monophosphate mediates the lipolytic action of parathyroid hormone

Thajchayapong, P., Queener, S. F., McClintock, R., Allen, D. O. & Bell, N. H., Jan 1 1976, In : Unknown Journal. 8, 3, p. 190-195 6 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Cyclic AMP
Lipolysis
Demonstrations
Hormones

Depletion of hepatic UDP-glucuronic acid (UDPGA) decreases the biliary excretion of drugs

Watkins, J. B., Gregus, Z., Thompson, T. B. & Klaassen, C. D., Jan 1 1982, In : Hepatology. 2, 5, p. No. 119

Research output: Contribution to journalArticle

Uridine Diphosphate Glucuronic Acid
Liver
Pharmaceutical Preparations
Hepatobiliary Elimination
30 Citations (Scopus)

Depletion of hepatic uridine diphosphoglucuronic acid decreases the biliary excretion of drugs

Gregus, Z., Watkins, J. B., Thompson, T. N. & Klaassen, C. D., Jan 1 1983, In : Journal of Pharmacology and Experimental Therapeutics. 225, 2, p. 256-262 7 p.

Research output: Contribution to journalArticle

Uridine Diphosphate Glucuronic Acid
Galactosamine
Ether
Liver
Iopanoic Acid
50 Citations (Scopus)
Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Substitution reactions
Pneumocystis carinii
Mycobacterium avium
36 Citations (Scopus)
Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Toxoplasma
Mycobacterium avium
Pyrimidines
20 Citations (Scopus)

Design, synthesis, and computational affinity prediction of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii

Graffner-Nordberg, M., Kolmodin, K., Åqvist, J., Queener, S. F. & Hallberg, A., May 2004, In : European Journal of Pharmaceutical Sciences. 22, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Esters
Inhalation Administration
32 Citations (Scopus)

Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; Application of buchwald-hartwig aminations of heterocycles

Gangjee, A., Namjoshi, O. A., Raghavan, S., Queener, S. F., Kisliuk, R. L. & Cody, V., Jun 13 2013, In : Journal of Medicinal Chemistry. 56, 11, p. 4422-4441 20 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Amination
Pneumocystis carinii
Mycobacterium avium
Opportunistic Infections
71 Citations (Scopus)

Design, synthesis, and x-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent

Gangjee, A., Yu, J., McGuire, J. J., Cody, V., Galitsky, N., Kisliuk, R. L. & Queener, S. F., Oct 19 2000, In : Journal of Medicinal Chemistry. 43, 21, p. 3837-3851 15 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Methotrexate
Antineoplastic Agents
Crystal structure
Cells
29 Citations (Scopus)

Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors

Gangjee, A., Li, W., Lin, L., Zeng, Y., Ihnat, M., Warnke, L. A., Green, D. W., Cody, V., Pace, J. & Queener, S. F., Oct 15 2009, In : Bioorganic and Medicinal Chemistry. 17, 20, p. 7324-7336 13 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pyrimidines
Tetrahydrofolate Dehydrogenase
Protein-Tyrosine Kinases
Crystal structure
23 Citations (Scopus)

Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens

Bag, S., Tawari, N. R., Degani, M. S. & Queener, S. F., May 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 9, p. 3187-3197 11 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Pathogens
Pneumocystis carinii
Mycobacterium avium
84 Citations (Scopus)

Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from pneumocystis carinii

Graffner-Nordberg, M., Kolmodin, K., Åqvist, J., Queener, S. F. & Hallberg, A., Jul 19 2001, In : Journal of Medicinal Chemistry. 44, 15, p. 2391-2402 12 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Esters
Trimetrexate
8 Citations (Scopus)
Folic Acid Antagonists
Pyrimidines
Tetrahydrofolate Dehydrogenase
Rats
Addition reactions
192 Citations (Scopus)

Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino- 5-ethylpyrrolo[2,3-d]pyrimidines as antifolates

Gangjee, A., Zeng, Y., Talreja, T., McGuire, J. J., Kisliuk, R. L. & Queener, S. F., Jun 28 2007, In : Journal of Medicinal Chemistry. 50, 13, p. 3046-3053 8 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pyrimidines
Sulfhydryl Compounds
Glutamic Acid
Saponification
11 Citations (Scopus)

Determinant of the extracellular location of the N-terminus of human multidrug-resistance-associated protein

Zhang, J. T., Jun 15 2000, In : Biochemical Journal. 348, 3, p. 597-606 10 p.

Research output: Contribution to journalArticle

Multidrug Resistance-Associated Proteins
Membranes
Protein Folding
Adenosine Triphosphate
Signal Recognition Particle
8 Citations (Scopus)

Determinants of 14-3-3σ protein dimerization and function in drug and radiation resistance

Li, Z., Peng, H., Qin, L., Qi, J., Zuo, X., Liu, J. Y. & Zhang, J. T., Nov 1 2013, In : Journal of Biological Chemistry. 288, 44, p. 31447-31457 11 p.

Research output: Contribution to journalArticle

Protein Multimerization
14-3-3 Proteins
Dimerization
Drug Resistance
Radiation

Determination of hepatic uridine 5'-diphosphoglucuronic acid (UDPGA) by conjugation with dimethylstilbestrol (DES)

Watkins, J. B. & Klaassen, C. D., Jan 1 1981, In : Pharmacologist. 23, 3, p. No. 237

Research output: Contribution to journalArticle

Uridine Diphosphate Glucuronic Acid
Liver
dimethylstilbestrol
33 Citations (Scopus)

Determination of hepatic uridine 5′-diphosphoglucuronic acid concentration by conjugation with diethylstilbestrol

Watkins, J. B. & Klaassen, C. D., Mar 1982, In : Journal of Pharmacological Methods. 7, 2, p. 145-151 7 p.

Research output: Contribution to journalArticle

Uridine Diphosphate Glucuronic Acid
Diethylstilbestrol
Uridine
Acids
Liver
24 Citations (Scopus)

Determination of mouse bladder inflammatory response to E. coli lipopolysaccharide

Jerde, T. J., Bjorling, D. E., Steinberg, H., Warner, T. & Saban, R., Jan 1 2000, In : Urological Research. 28, 4, p. 269-273 5 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Urinary Bladder
Escherichia coli
Inflammation
Cystitis
14 Citations (Scopus)

Developmental changes in neuromuscular transmission in the rat diaphragm

Feldman, J. D., Bazzy, A. R., Cummins, T. R. & Haddad, G. G., Jan 1 1991, In : Journal of Applied Physiology. 71, 1, p. 280-286 7 p.

Research output: Contribution to journalArticle

Diaphragm
Phrenic Nerve
Muscles
Neuromuscular Junction
Muscle Cells
3 Citations (Scopus)

Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases

Prabhu, L., Chen, L., Wei, H., Demir, Ö., Safa, A., Zeng, L., Amaro, R. E., O'Neil, B. H., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Molecular BioSystems. 13, 12, p. 2509-2520 12 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Histones
Methylation
Arginine
Streptavidin
23 Citations (Scopus)

Development of dispositional tolerance to phencyclidine by osmotic minipump in the mouse

Toshitaka, N., Sivam, S. P., Tai, C. Y. & Ho, I. K., May 1982, In : Journal of Pharmacological Methods. 7, 3, p. 239-253 15 p.

Research output: Contribution to journalArticle

Phencyclidine
Ataxia
Cytochromes b5
Inbred ICR Mouse
Phosphoric Monoester Hydrolases

Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection

Shah, K., Queener, S., Cody, V., Pace, J. & Gangjee, A., Aug 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 15, p. 1874-1880 7 p.

Research output: Contribution to journalArticle

Pneumocystis Infections
Folic Acid Antagonists
Pneumocystis Pneumonia
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
21 Citations (Scopus)

Development of UDP-glucuronosyltransferase activity toward digitoxigenin-monodigitoxoside in neonatal rats

Watkins, J. B. & Klaassen, C. D., Jan 1 1985, In : Drug Metabolism and Disposition. 13, 2, p. 186-191 6 p.

Research output: Contribution to journalArticle

Glucuronosyltransferase
Rats
Morphine
Diethylstilbestrol
Valproic Acid
8 Citations (Scopus)

DHA2, a synthesized derivative of bisbibenzyl, exerts antitumor activity against ovarian cancer through inhibition of XIAP and Akt/mTOR pathway

Pang, Y., Si, M., Sun, B., Niu, L., Xu, X., Lu, T., Yuan, H. & Lou, H., Jul 2014, In : Food and Chemical Toxicology. 69, p. 163-174 12 p.

Research output: Contribution to journalArticle

X-Linked Inhibitor of Apoptosis Protein
ovarian neoplasms
Cell death
Ovarian Neoplasms
cell death
20 Citations (Scopus)

Diacylglycerol modulates action potential frequency in GH3 pituitary cells: correlative biochemical and electrophysiological studies

Gammon, C. M., Oxford, G. S., Allen, A. C., McCarthy, K. D. & Morell, P., Feb 13 1989, In : Brain research. 479, 2, p. 217-224 8 p.

Research output: Contribution to journalArticle

Diglycerides
Prolactin
Action Potentials
Calcium
Phorbol Esters
38 Citations (Scopus)

Diagnosis of pneumocystis carinii pneumonia in aids patients by using polymerase chain reactions on serum specimens

Atzori, C., Lu, J. J., Jiang, B., Bartlett, M. S., Orlando, G., Queener, S. F., Smith, J. W., Cargnel, A. & Lee, C. H., Dec 1995, In : Journal of Infectious Diseases. 172, 6, p. 1623-1626 4 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Polymerase Chain Reaction
Serum
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
16 Citations (Scopus)

Dichloroacetate alters Warburg metabolism, inhibits cell growth, and increases the X-ray sensitivity of human A549 and H1299 NSC lung cancer cells

Tan Allen, K., Chin-Sinex, H., DeLuca, T., Pomerening, J. R., Sherer, J., Watkins, J. B., Foley, J., Jesseph, J. M. & Mendonca, M., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 263-273 11 p., 12539.

Research output: Contribution to journalArticle

Cell growth
Metabolism
Lung Neoplasms
Cells
X-Rays
142 Citations (Scopus)
Voltage-Gated Sodium Channels
Carbamazepine
Lidocaine
Pain
Nociceptors
203 Citations (Scopus)

Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations

Yamamoto, B. K. & Cooperman, M. A., Jul 1 1994, In : Journal of Neuroscience. 14, 7, p. 4159-4166 8 p.

Research output: Contribution to journalArticle

Clozapine
Antipsychotic Agents
Glutamic Acid
Dopamine
Nucleus Accumbens
7 Citations (Scopus)

Differential effects of d-amphetamine on brain acetylcholine in young, adult and geriatric rats

Vasko, M. R., Domino, L. E. & Domino, E. F., Jun 1974, In : European Journal of Pharmacology. 27, 1, p. 145-147 3 p.

Research output: Contribution to journalArticle

Dextroamphetamine
Geriatrics
Acetylcholine
Young Adult
Brain
76 Citations (Scopus)
Clozapine
Haloperidol
Prefrontal Cortex
Rats
Dopamine
75 Citations (Scopus)

Differential expression of P‐glycoprotein genes in primary rat hepatocyte culture

Lee, C. H., Bradley, G., Zhang, JT. T. & Ling, V., Nov 1993, In : Journal of cellular physiology. 157, 2, p. 392-402 11 p.

Research output: Contribution to journalArticle

Cell culture
MHC Class II Genes
Rats
Hepatocytes
Genes
24 Citations (Scopus)

Differential gene expression of neonatal and adult DRG neurons correlates with the differential sensitization of TRPV1 responses to nerve growth factor

Zhu, W. & Oxford, G. S., Aug 18 2011, In : Neuroscience Letters. 500, 3, p. 192-196 5 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Nerve Growth Factor
Gene Expression
Neurons
Phosphatidylinositol 3-Kinases
86 Citations (Scopus)

Differential regulation of evoked peptide release by voltage-sensitive calcium channels in rat sensory neurons

Evans, A. R., Nicol, G. D. & Vasko, M. R., Mar 18 1996, In : Brain research. 712, 2, p. 265-273 9 p.

Research output: Contribution to journalArticle

Conotoxins
Sensory Receptor Cells
Calcium Channels
Agatoxins
Dinoprostone
16 Citations (Scopus)

Differential responses of Ca-activated K channels to bradykinin in sensory neurons and F-11 cells

Naruse, K., McGehee, D. S. & Oxford, G. S., Apr 6 1992, In : American Journal of Physiology - Cell Physiology. 262, 2 31-2, p. C453-C460

Research output: Contribution to journalArticle

Spinal Ganglia
Bradykinin
Sensory Receptor Cells
Neurons
Chemical activation
11 Citations (Scopus)

Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model

Ozcelikkale, A., Shin, K., Noe-Kim, V., Elzey, B. D., Dong, Z., Zhang, J-T., Kim, K., Kwon, I. C., Park, K. & Han, B., Nov 28 2017, In : Journal of Controlled Release. 266, p. 129-139 11 p.

Research output: Contribution to journalArticle

Microfluidics
Doxorubicin
Tumor Microenvironment
Breast Neoplasms
Drug Resistance
175 Citations (Scopus)

Differential role of GDNF and NGF in the maintenance of two TTX- resistant sodium channels in adult DRG neurons

Fjell, J., Cummins, T. R., Dib-Hajj, S. D., Fried, K., Black, J. A. & Waxman, S. G., Apr 20 1999, In : Molecular Brain Research. 67, 2, p. 267-282 16 p.

Research output: Contribution to journalArticle

Glial Cell Line-Derived Neurotrophic Factor
Sodium Channels
Spinal Ganglia
Nerve Growth Factor
Maintenance
16 Citations (Scopus)

Differential splicing of Pneumocystis carinii f. sp. carinii inosine 5′-monophosphate dehydrogenase pre-mRNA

Ye, D., Lee, C. H. & Queener, S. F., Jan 24 2001, In : Gene. 263, 1-2, p. 151-158 8 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Pneumocystis carinii
RNA Precursors
Enzymes
Amino Acids
7 Citations (Scopus)

Different roles of TM5, TM6, and ECL3 in the oligomerization and function of human ABCG2

Mo, W., Qi, J. & Zhang, J. T., May 1 2012, In : Biochemistry. 51, 17, p. 3634-3641 8 p.

Research output: Contribution to journalArticle

Oligomerization
ATP-Binding Cassette Transporters
Neoplastic Stem Cells
Multiple Drug Resistance
Site-Directed Mutagenesis
21 Citations (Scopus)

Dihydropyridine receptor isoform expression in adult rat skeletal muscle

Péréon, Y., Dettbarn, C., Lu, Y., Westlund, K. N., Zhang, J. T. & Palade, P., Jul 27 1998, In : Pflugers Archiv European Journal of Physiology. 436, 3, p. 309-314 6 p.

Research output: Contribution to journalArticle

L-Type Calcium Channels
Muscle
Rats
Protein Isoforms
Skeletal Muscle