Pharmacology & Toxicology

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2009

Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii - A Review

Sullivan, W. J., Smith, A. T. & Joyce, B. R., Mar 2009, In : Memorias do Instituto Oswaldo Cruz. 104, 2, p. 155-161 7 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFκB

Lu, T., Jackson, M. W., Singhi, A. D., Kandel, E. S., Yang, M., Zhang, Y., Gudkov, A. V. & Stark, G. R., Sep 22 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 38, p. 16339-16344 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Voltage-clamp and current-clamp recordings from mammalian DRG neurons

Cummins, T. R., Rush, A. M., Estacion, M., Dib-Hajj, S. D. & Waxman, S. G., Aug 17 2009, In : Nature protocols. 4, 8, p. 1103-1112 10 p.

Research output: Contribution to journalArticle

69 Scopus citations
2008

A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence

Saeij, J. P. J., Arrizabalaga, G. & Boothroyd, J. C., Jun 2008, In : Infection and immunity. 76, 6, p. 2402-2410 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1

Jeske, N. A., Diogenes, A., Ruparel, N. B., Fehrenbacher, J. C., Henry, M., Akopian, A. N. & Hargreaves, K. M., Sep 15 2008, In : Pain. 138, 3, p. 604-616 13 p.

Research output: Contribution to journalArticle

78 Scopus citations

Analysis of changes in the proteome of HL-60 promyeloid leukemia cells induced by the proteasome inhibitor PSI

Choi, M. R., Najafi, F., Safa, A. R. & Drexler, H. C. A., Jun 15 2008, In : Biochemical Pharmacology. 75, 12, p. 2276-2288 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

A new mechanism of drug resistance in breast cancer cells: Fatty acid synthase overexpression-mediated palmitate overproduction

Liu, H., Liu, Y. & Zhang, J. T., Feb 1 2008, In : Molecular cancer therapeutics. 7, 2, p. 263-270 8 p.

Research output: Contribution to journalArticle

115 Scopus citations

Attenuation of TCDD-induced oxidative stress by 670 nm photobiomodulation in developmental chicken kidney

Lim, J., Sanders, R. A., Yeager, R. L., Millsap, D. S., Watkins, J. B., Eells, J. T. & Henshel, D. S., Sep 9 2008, In : Journal of Biochemical and Molecular Toxicology. 22, 4, p. 230-239 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Azurin-like protein blocks invasion of Toxoplasma gondii through potential interactions with parasite surface antigen SAG1

Naguleswaran, A., Fialho, A. M., Chaudhari, A., Chang, S. H., Chakrabarty, A. M. & Sullivan, W. J., Feb 1 2008, In : Antimicrobial Agents and Chemotherapy. 52, 2, p. 402-408 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
38 Scopus citations

c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells

Day, T. W., Huang, S. & Safa, A. R., Dec 15 2008, In : Biochemical Pharmacology. 76, 12, p. 1694-1704 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

Chronic stress enhances methamphetamine-induced extracellular glutamate and excitotoxicity in the rat striatum

Tata, D. A. & Yamamoto, B. K., May 2008, In : Synapse. 62, 5, p. 325-336 12 p.

Research output: Contribution to journalArticle

39 Scopus citations
144 Scopus citations

Effect of cysteine mutagenesis on the function and disulfide bond formation of human ABCG2

Liu, Y., Yang, Y., Qi, J., Peng, H. & Zhang, J. T., Jul 2008, In : Journal of Pharmacology and Experimental Therapeutics. 326, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Exit from host cells by the pathogenic parasite Toxoplasma gondii does not require motility

Lavine, M. D. & Arrizabalaga, G., Jan 2008, In : Eukaryotic Cell. 7, 1, p. 131-140 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Gender differences in zebrafish responses to cocaine withdrawal

López Patiño, M. A., Yu, L., Yamamoto, B. K. & Zhdanova, I. V., Sep 3 2008, In : Physiology and Behavior. 95, 1-2, p. 36-47 12 p.

Research output: Contribution to journalArticle

71 Scopus citations

Human DNA polymerase η activity and translocation is regulated by phosphorylation

Chen, Y. W., Cleaver, J. E., Hatahet, Z., Honkanen, R. E., Chang, J. Y., Yen, Y. & Chou, K. M., Oct 28 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16578-16583 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
90 Scopus citations

Intrinsic disorder in pathogenic and non-pathogenic microbes: Discovering and analyzing the unfoldomes of early-branching eukaryotes

Mohan, A., Sullivan, W. J., Radivojac, P., Dunker, A. K. & Uversky, V. N., Mar 28 2008, In : Molecular BioSystems. 4, 4, p. 328-340 13 p.

Research output: Contribution to journalArticle

93 Scopus citations

L-DOPA-induced activation of striatal p38MAPK and CREB in neonatal dopaminergic denervated rat: Relevance to self-injurious behavior

Sivam, S. P., Pugazhenthi, S., Pugazhenthi, V. & Brown, H., Feb 1 2008, In : Journal of Neuroscience Research. 86, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Measurements of mitochondrial pH in cultured cortical neurons clarify contribution of mitochondrial pore to the mechanism of glutamate-induced delayed Ca2+ deregulation

Bolshakov, A. P., Mikhailova, M. M., Szabadkai, G., Pinelis, V. G., Brustovetsky, N., Rizzuto, R. & Khodorov, B. I., Jun 2008, In : Cell Calcium. 43, 6, p. 602-614 13 p.

Research output: Contribution to journalArticle

37 Scopus citations
34 Scopus citations

Nerve growth factor, sphingomyelins, and sensitization in sensory neurons

Nicol, G. D., Oct 25 2008, In : Sheng li xue bao : [Acta physiologica Sinica]. 60, 5, p. 603-604 2 p.

Research output: Contribution to journalArticle

11 Scopus citations

N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons

Rimmerman, N., Bradshaw, H. B., Hughes, H. V., Chen, J. S. C., Hu, S. S. J., McHugh, D., Vefring, E., Jahnsen, J. A., Thompson, E. L., Masuda, K., Cravatt, B. F., Burstein, S., Vasko, M. R., Prieto, A. L., O'Dell, D. K. & Walker, J. M., Jul 2008, In : Molecular pharmacology. 74, 1, p. 213-224 12 p.

Research output: Contribution to journalArticle

61 Scopus citations

Oligomeric BAX induces mitochondrial permeability transition and complete cytochrome c release without oxidative stress

Li, T., Brustovetsky, T., Antonsson, B. & Brustovetsky, N., Nov 1 2008, In : Biochimica et Biophysica Acta - Bioenergetics. 1777, 11, p. 1409-1421 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Paroxysmal extreme pain disorder M1627K mutation in human Nav 1.7 renders DRG neurons hyperexcitable

Dib-Hajj, S. D., Estacion, M., Jarecki, B. W., Tyrrell, L., Fischer, T. Z., Lawden, M., Cummins, T. R. & Waxman, S. G., Sep 19 2008, In : Molecular Pain. 4, 37.

Research output: Contribution to journalArticle

87 Scopus citations

Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation

Jarecki, B. W., Sheets, P. L., Jackson, J. O. & Cummins, T. R., 2008, In : Journal of Physiology. 586, 17, p. 4137-4153 17 p.

Research output: Contribution to journalArticle

61 Scopus citations

Preparation and evaluation of a high-strength biocompatible glass-ionomer cement for improved dental restoratives.

Xie, D., Zhao, J., Yang, Y., Park, J., Chu, T. M. & Zhang, J. T., Jun 2008, In : Biomedical materials (Bristol, England). 3, 2, 1 p.

Research output: Contribution to journalArticle

4 Scopus citations
2 Scopus citations

Silencing S1P1 receptors regulates collagen-V reactive lymphocyte-mediated immunobiology in the transplanted lung

Chiyo, M., Iwata, T., Webb, T. J., Vasko, M. R., Thompson, E. L., Heidler, K. M., Cummings, O. W., Yoshida, S., Fujisawa, T., Brand, D. D. & Wilkes, D. S., Mar 2008, In : American Journal of Transplantation. 8, 3, p. 537-546 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Spinal N-methyl-d-aspartate receptors and nociception-evoked release of primary afferent substance P

Nazarian, A., Gu, G., Gracias, N. G., Wilkinson, K., Hua, X. Y., Vasko, M. R. & Yaksh, T. L., Mar 3 2008, In : Neuroscience. 152, 1, p. 119-127 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain II voltage sensor in the closed configuration

Xiao, Y., Bingham, J. P., Zhu, W., Moczydlowski, E., Liang, S. & Cummins, T. R., Oct 3 2008, In : Journal of Biological Chemistry. 283, 40, p. 27300-27313 14 p.

Research output: Contribution to journalArticle

123 Scopus citations
28 Scopus citations

The transcription of bradyzoite genes in Toxoplasma gondii is controlled by autonomous promoter elements

Behnke, M. S., Radke, J. B., Smith, A. T., Sullivan, W. J. & White, M. W., Jun 2008, In : Molecular Microbiology. 68, 6, p. 1502-1518 17 p.

Research output: Contribution to journalArticle

72 Scopus citations
26 Scopus citations

TRAIL recombinant adenovirus triggers robust apoptosis in multidrug-resistant HL-60/Vinc cells preferentially through death receptor DR5

Wu, C. H., Kao, C. H. & Safa, A. R., Jul 1 2008, In : Human gene therapy. 19, 7, p. 731-743 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii

Narasimhan, J., Joyce, B. R., Naguleswaran, A., Smith, A. T., Livingston, M. R., Dixon, S. E., Coppens, I., Wek, R. C. & Sullivan, W. J., Jun 13 2008, In : Journal of Biological Chemistry. 283, 24, p. 16591-16601 11 p.

Research output: Contribution to journalArticle

75 Scopus citations

Use of non-mammalian alternative models for neurotoxicological study

Peterson, R. T., Nass, R., Boyd, W. A., Freedman, J. H., Dong, K. & Narahashi, T., May 2008, In : NeuroToxicology. 29, 3, p. 546-555 10 p.

Research output: Contribution to journalArticle

122 Scopus citations
2007

Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I

Zhu, W., Xu, P., Cuascut, F. X., Hall, A. K. & Oxford, G. S., Dec 12 2007, In : Journal of Neuroscience. 27, 50, p. 13770-13780 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

A Nav 1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity

Sheets, P. L., Jackson, J. O., Waxman, S. G., Dib-hajj, S. D. & Cummins, T. R., Jun 1 2007, In : Journal of Physiology. 581, 3, p. 1019-1031 13 p.

Research output: Contribution to journalArticle

127 Scopus citations

A novel comonomer-free light-cured glass-ionomer cement for reduced cytotoxicity and enhanced mechanical strength

Xie, D., Yang, Y., Zhao, J., Park, J. G. & Zhang, J. T., Aug 1 2007, In : Dental Materials. 23, 8, p. 994-1003 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

A rapid oxidation and persistent decrease in the vesicular monoamine transporter 2 after methamphetamine

Eyerman, D. J. & Yamamoto, B. K., Nov 2007, In : Journal of Neurochemistry. 103, 3, p. 1219-1227 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

ATP-sensitive potassium currents reduce the PGE2-mediated enhancement of excitability in adult rat sensory neurons

Chi, X. X., Jiang, X. & Nicol, G. D., May 11 2007, In : Brain research. 1145, 1, p. 28-40 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Augmentation of methamphetamine-induced toxicity in the rat striatum by unpredictable stress: Contribution of enhanced hyperthermia

Tata, D. A., Raudensky, J. & Yamamoto, B. K., Aug 2007, In : European Journal of Neuroscience. 26, 3, p. 739-748 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

c-Jun promotes cellular survival by suppression of PTEN

Hettinger, K., Vikhanskaya, F., Poh, M. K., Lee, M. K., de Belle, I., Zhang, J. T., Reddy, S. A. G. & Sabapathy, K., Feb 1 2007, In : Cell Death and Differentiation. 14, 2, p. 218-229 12 p.

Research output: Contribution to journalArticle

103 Scopus citations

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

Juang, S. H., Lung, C. C., Hsu, P. C., Hsu, K. S., Li, Y. C., Hong, P. C., Shiah, H. S., Kuo, C. C., Huang, C. W., Wang, Y. C., Huang, L., Chen, T. S., Chen, S. F., Fu, K. C., Hsu, C. L., Lin, M. J., Chang, C. J., Ashendel, C. L., Chan, T. C. K., Chou, K. M. & 1 others, Chang, J. C., Jan 1 2007, In : Molecular cancer therapeutics. 6, 1, p. 193-202 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino- 5-ethylpyrrolo[2,3-d]pyrimidines as antifolates

Gangjee, A., Zeng, Y., Talreja, T., McGuire, J. J., Kisliuk, R. L. & Queener, S. F., Jun 28 2007, In : Journal of Medicinal Chemistry. 50, 13, p. 3046-3053 8 p.

Research output: Contribution to journalArticle

207 Scopus citations
168 Scopus citations

Dose-dependent cross-talk between the transforming growth factor-β and interleukin-1 signaling pathways

Lu, T., Tian, L., Han, Y., Vogelbaum, M. & Stark, G. R., Mar 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4365-4370 6 p.

Research output: Contribution to journalArticle

83 Scopus citations

Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release

Mark, K. A., Quinton, M. S., Russek, S. J. & Yamamoto, B. K., Jun 20 2007, In : Journal of Neuroscience. 27, 25, p. 6823-6831 9 p.

Research output: Contribution to journalArticle

50 Scopus citations