Pharmacology & Toxicology

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2008

Recombinant bovine dihydrofolate reductase produced by mutagenesis and nested PCR of murine dihydrofolate reductase cDNA

Cody, V., Mao, Q. & Queener, S. F., Nov 1 2008, In : Protein Expression and Purification. 62, 1, p. 104-110 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Silencing S1P1 receptors regulates collagen-V reactive lymphocyte-mediated immunobiology in the transplanted lung

Chiyo, M., Iwata, T., Webb, T. J., Vasko, M. R., Thompson, E. L., Heidler, K. M., Cummings, O. W., Yoshida, S., Fujisawa, T., Brand, D. D. & Wilkes, D. S., Mar 1 2008, In : American Journal of Transplantation. 8, 3, p. 537-546 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Spinal N-methyl-d-aspartate receptors and nociception-evoked release of primary afferent substance P

Nazarian, A., Gu, G., Gracias, N. G., Wilkinson, K., Hua, X. Y., Vasko, M. R. & Yaksh, T. L., Mar 3 2008, In : Neuroscience. 152, 1, p. 119-127 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain II voltage sensor in the closed configuration

Xiao, Y., Bingham, J. P., Zhu, W., Moczydlowski, E., Liang, S. & Cummins, T. R., Oct 3 2008, In : Journal of Biological Chemistry. 283, 40, p. 27300-27313 14 p.

Research output: Contribution to journalArticle

120 Scopus citations
28 Scopus citations

The transcription of bradyzoite genes in Toxoplasma gondii is controlled by autonomous promoter elements

Behnke, M. S., Radke, J. B., Smith, A. T., Sullivan, W. J. & White, M. W., Jun 1 2008, In : Molecular Microbiology. 68, 6, p. 1502-1518 17 p.

Research output: Contribution to journalArticle

71 Scopus citations
26 Scopus citations

TRAIL recombinant adenovirus triggers robust apoptosis in multidrug-resistant HL-60/Vinc cells preferentially through death receptor DR5

Wu, C. H., Kao, C. H. & Safa, A. R., Jul 1 2008, In : Human gene therapy. 19, 7, p. 731-743 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii

Narasimhan, J., Joyce, B. R., Naguleswaran, A., Smith, A. T., Livingston, M. R., Dixon, S. E., Coppens, I., Wek, R. C. & Sullivan, W. J., Jun 13 2008, In : Journal of Biological Chemistry. 283, 24, p. 16591-16601 11 p.

Research output: Contribution to journalArticle

75 Scopus citations

Use of non-mammalian alternative models for neurotoxicological study

Peterson, R. T., Nass, R., Boyd, W. A., Freedman, J. H., Dong, K. & Narahashi, T., May 2008, In : NeuroToxicology. 29, 3, p. 546-555 10 p.

Research output: Contribution to journalArticle

121 Scopus citations
2007

Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I

Zhu, W., Xu, P., Cuascut, F. X., Hall, A. K. & Oxford, G. S., Dec 12 2007, In : Journal of Neuroscience. 27, 50, p. 13770-13780 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

A Nav 1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity

Sheets, P. L., Jackson, J. O., Waxman, S. G., Dib-hajj, S. D. & Cummins, T. R., Jun 1 2007, In : Journal of Physiology. 581, 3, p. 1019-1031 13 p.

Research output: Contribution to journalArticle

126 Scopus citations

A novel comonomer-free light-cured glass-ionomer cement for reduced cytotoxicity and enhanced mechanical strength

Xie, D., Yang, Y., Zhao, J., Park, J. G. & Zhang, J. T., Aug 1 2007, In : Dental Materials. 23, 8, p. 994-1003 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

ATP-sensitive potassium currents reduce the PGE2-mediated enhancement of excitability in adult rat sensory neurons

Chi, X. X., Jiang, X. & Nicol, G. D., May 11 2007, In : Brain research. 1145, 1, p. 28-40 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

c-Jun promotes cellular survival by suppression of PTEN

Hettinger, K., Vikhanskaya, F., Poh, M. K., Lee, M. K., de Belle, I., Zhang, J. T., Reddy, S. A. G. & Sabapathy, K., Feb 1 2007, In : Cell Death and Differentiation. 14, 2, p. 218-229 12 p.

Research output: Contribution to journalArticle

102 Scopus citations

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

Juang, S. H., Lung, C. C., Hsu, P. C., Hsu, K. S., Li, Y. C., Hong, P. C., Shiah, H. S., Kuo, C. C., Huang, C. W., Wang, Y. C., Huang, L., Chen, T. S., Chen, S. F., Fu, K. C., Hsu, C. L., Lin, M. J., Chang, C. J., Ashendel, C. L., Chan, T. C. K., Chou, K. M. & 1 others, Chang, J. C., Jan 1 2007, In : Molecular cancer therapeutics. 6, 1, p. 193-202 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino- 5-ethylpyrrolo[2,3-d]pyrimidines as antifolates

Gangjee, A., Zeng, Y., Talreja, T., McGuire, J. J., Kisliuk, R. L. & Queener, S. F., Jun 28 2007, In : Journal of Medicinal Chemistry. 50, 13, p. 3046-3053 8 p.

Research output: Contribution to journalArticle

206 Scopus citations
168 Scopus citations

Lithium desensitizes brain mitochondria to calcium, antagonizes permeability transition, and diminishes cytochrome c release

Shalbuyeva, N., Brustovetsky, T. & Brustovetsky, N., Jun 22 2007, In : Journal of Biological Chemistry. 282, 25, p. 18057-18068 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Manipulation of the potassium channel Kv1.1 and its effect on neuronal excitability in rat sensory neurons

Xian, X. C. & Nicol, G. D., Nov 1 2007, In : Journal of Neurophysiology. 98, 5, p. 2683-2692 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Melatonin as a principal component of red light therapy

Yeager, R. L., Oleske, D. A., Sanders, R. A., Watkins, J. B., Eells, J. T. & Henshel, D. S., Jun 1 2007, In : Medical Hypotheses. 69, 2, p. 372-376 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mitochondria-mediated and p53-associated apoptosis induced in human cancer cells by a novel selenophene derivative, D-501036

Shiah, H. S., Lee, W. S., Juang, S. H., Hong, P. C., Lung, C. C., Chang, C. J., Chou, K. M. & Chang, J. Y., Mar 1 2007, In : Biochemical Pharmacology. 73, 5, p. 610-619 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Molecular interactions of the gating modifier toxin ProTx-II with Na v1.5: Implied existence of a novel toxin binding site coupled to activation

Smith, J. J., Cummins, T. R., Alphy, S. & Blumenthal, K. M., Apr 27 2007, In : Journal of Biological Chemistry. 282, 17, p. 12687-12697 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Novel boron-containing, nonclassical antifolates: Synthesis and preliminary biological and structural evaluation

Reynolds, R. C., Campbell, S. R., Fairchild, R. G., Kisliuk, R. L., Micca, P. L., Queener, S. F., Riordan, J. M., Sedwick, W. D., Waud, W. R., Leung, A. K. W., Dixon, R. W., Suling, W. J. & Borhani, D. W., Jul 12 2007, In : Journal of Medicinal Chemistry. 50, 14, p. 3283-3289 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Oligomerization domain of the multidrug resistance-associated transporter ABCG2 and its dominant inhibitory activity

Xu, J., Peng, H., Chen, Q., Liu, Y., Dong, Z. & Zhang, J. T., May 1 2007, In : Cancer Research. 67, 9, p. 4373-4381 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1

Zhu, W. & Oxford, G. S., Apr 1 2007, In : Molecular and Cellular Neuroscience. 34, 4, p. 689-700 12 p.

Research output: Contribution to journalArticle

115 Scopus citations
12 Scopus citations

Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii

Smith, A. T., Livingston, M. R., Mai, A., Filetici, P., Queener, S. F. & Sullivan, W. J., Mar 1 2007, In : Antimicrobial Agents and Chemotherapy. 51, 3, p. 1109-1111 3 p.

Research output: Contribution to journalArticle

27 Scopus citations

Regulation of function by dimerization through the amino-terminal membrane-spanning domain of human ABCC1/MRP1

Yang, Y., Liu, Y., Dong, Z., Xu, J., Peng, H., Liu, Z. & Zhang, J. T., Mar 23 2007, In : Journal of Biological Chemistry. 282, 12, p. 8821-8830 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development

Liu, Z., Dong, Z., Yang, Z., Chen, Q., Pan, Y., Yang, Y., Cui, P., Zhang, X. & Zhang, J. T., Sep 2007, In : Differentiation. 75, 7, p. 652-661 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
26 Scopus citations

Suppression of endogenous antioxidant enzymes by 2,3,7,8- tetrachlorodibenzo-p-dioxin-induced oxidative stress in chicken liver during development

Lim, J., DeWitt, J. C., Sanders, R. A., Watkins, J. B. & Henshel, D. S., May 1 2007, In : Archives of Environmental Contamination and Toxicology. 52, 4, p. 590-595 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
35 Scopus citations
2006

670 Nanometer light treatment attenuates dioxin toxicity in the developing chick embryo

Yeager, R. L., Lim, J., Millsap, D. S., Jasevicius, A. V., Sanders, R. A., Whelan, H. T., Watkins, J. B., Eells, J. T. & Henshel, D. S., Dec 1 2006, In : Journal of Biochemical and Molecular Toxicology. 20, 6, p. 271-278 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

A novel role of DNA polymerase η in modulating cellular sensitivity to chemotherapeutic agents

Chen, Y. W., Cleaver, J. E., Hanaoka, F., Chang, C. F. & Chou, K. M., Apr 1 2006, In : Molecular Cancer Research. 4, 4, p. 257-265 9 p.

Research output: Contribution to journalArticle

96 Scopus citations

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

Rush, A. M., Dib-Hajj, S. D., Liu, S., Cummins, T. R., Black, J. A. & Waxman, S. G., May 23 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 21, p. 8245-8250 6 p.

Research output: Contribution to journalArticle

291 Scopus citations

Calcium-dependent spontaneously reversible remodeling of brain mitochondria

Shalbuyeva, N., Brustovetsky, T., Bolshakov, A. & Brustovetsky, N., Dec 8 2006, In : Journal of Biological Chemistry. 281, 49, p. 37547-37558 12 p.

Research output: Contribution to journalArticle

55 Scopus citations

Cellular FLICE-like inhibitory protein (c-FLIP): A novel target for Taxol-induced apoptosis

Day, T. W., Najafi, F., Wu, C. H. & Safa, A. R., May 28 2006, In : Biochemical Pharmacology. 71, 11, p. 1551-1561 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Effects of low-carbohydrate diet and Pycnogenol® treatment on retinal antioxidant enzymes in normal and diabetic rats

Kamuren, Z. T., McPeek, C. G., Sanders, R. A. & Watkins, J. B., Feb 1 2006, In : Journal of Ocular Pharmacology and Therapeutics. 22, 1, p. 10-18 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Identification of 14-3-3σ as a contributor to drug resistance in human breast cancer cells using functional proteomic analysis

Liu, Y., Liu, H., Han, B. & Zhang, J. T., Mar 15 2006, In : Cancer Research. 66, 6, p. 3248-3255 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor

Sheets, P. L., Gerner, P., Wang, C. F., Wang, S. Y., Ging, K. W. & Cummins, T. R., Oct 1 2006, In : Journal of Neurophysiology. 96, 4, p. 1848-1859 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
59 Scopus citations

Low-carbohydrate diet and oxidative stress in diabetic and nondiabetic rats

Kamuren, Z. T., Sanders, R. & Watkins, J. B., Oct 20 2006, In : Journal of Biochemical and Molecular Toxicology. 20, 5, p. 259-269 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

L-tyrosine contributes to (+)-3,4-methylenedioxymethamphetamine-induced serotonin depletions

Breier, J. M., Bankson, M. G. & Yamamoto, B. K., Jan 4 2006, In : Journal of Neuroscience. 26, 1, p. 290-299 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
14 Scopus citations

Pair of unusual GCN5 histone acetyltransferases and ADA2 homologues in the protozoan parasite Toxoplasma gondii

Bhatti, M. M., Livingston, M., Mullapudi, N. & Sullivan, W. J., Jan 1 2006, In : Eukaryotic Cell. 5, 1, p. 62-76 15 p.

Research output: Contribution to journalArticle

39 Scopus citations

P-glycoprotein enhances TRAIL-triggered apoptosis in multidrug resistant cancer cells by interacting with the death receptor DR5

Park, S. J., Wu, C. H., Choi, M. R., Najafi, F., Emami, A. & Safa, A. R., Jul 28 2006, In : Biochemical Pharmacology. 72, 3, p. 293-307 15 p.

Research output: Contribution to journalArticle

25 Scopus citations
6 Scopus citations

Sensitizing hormone-refractory prostate cancer cells to drug treatment by targeting 14-3-3σ

Han, B., Xie, H., Chen, Q. & Zhang, J. T., Apr 1 2006, In : Molecular cancer therapeutics. 5, 4, p. 903-912 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
63 Scopus citations