Pharmacology & Toxicology

Publications 1971 2020

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2008
8 Citations (Scopus)

Analysis of changes in the proteome of HL-60 promyeloid leukemia cells induced by the proteasome inhibitor PSI

Choi, M. R., Najafi, F., Safa, A. & Drexler, H. C. A., Jun 15 2008, In : Biochemical Pharmacology. 75, 12, p. 2276-2288 13 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Proteome
Leukemia
HL-60 Cells
Cells
103 Citations (Scopus)

A new mechanism of drug resistance in breast cancer cells: Fatty acid synthase overexpression-mediated palmitate overproduction

Liu, H., Liu, Y. & Zhang, J-T., Feb 1 2008, In : Molecular Cancer Therapeutics. 7, 2, p. 263-270 8 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Palmitates
Drug Resistance
Breast Neoplasms
Cell Line
10 Citations (Scopus)

Attenuation of TCDD-induced oxidative stress by 670 nm photobiomodulation in developmental chicken kidney

Lim, J., Sanders, R. A., Yeager, R. L., Millsap, D. S., Watkins, J. B., Eells, J. T. & Henshel, D. S., 2008, In : Journal of Biochemical and Molecular Toxicology. 22, 4, p. 230-239 10 p.

Research output: Contribution to journalArticle

Oxidative stress
Chickens
Oxidative Stress
Kidney
Lipid Peroxidation
14 Citations (Scopus)

Azurin-like protein blocks invasion of Toxoplasma gondii through potential interactions with parasite surface antigen SAG1

Naguleswaran, A., Fialho, A. M., Chaudhari, A., Chang, S. H., Chakrabarty, A. M. & Sullivan, W., Feb 2008, In : Antimicrobial Agents and Chemotherapy. 52, 2, p. 402-408 7 p.

Research output: Contribution to journalArticle

Azurin
Toxoplasma
Surface Antigens
Parasites
Proteins
36 Citations (Scopus)
Nerve Growth Factor Receptor
Sphingomyelins
Brain-Derived Neurotrophic Factor
Sensory Receptor Cells
Nerve Growth Factors
30 Citations (Scopus)

Caenorhabditis elegans in Parkinson's disease drug discovery: Addressing an unmet medical need

Nass, R., Merchant, K. M. & Ryan, T., Dec 1 2008, In : Molecular Interventions. 8, 6, p. 284-293 10 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Drug Discovery
Parkinson Disease
Lewy Bodies
Nerve Degeneration
134 Citations (Scopus)

Cellular FLICE-like inhibitory protein (C-FLIP): A novel target for cancer therapy

Safa, A., Day, T. W. & Wu, C. H., Feb 2008, In : Current Cancer Drug Targets. 8, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Staphylococcal Protein A
Neoplasms
Death Domain Receptor Signaling Adaptor Proteins
Caspase 8
56 Citations (Scopus)

c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells

Day, T. W., Huang, S. & Safa, A., Dec 15 2008, In : Biochemical Pharmacology. 76, 12, p. 1694-1704 11 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Caspase 9
Caspase 8
MCF-7 Cells
Cells
140 Citations (Scopus)
Voltage-Gated Sodium Channels
Carbamazepine
Lidocaine
Pain
Nociceptors
29 Citations (Scopus)

Effect of cysteine mutagenesis on the function and disulfide bond formation of human ABCG2

Liu, Y., Yang, Y., Qi, J., Peng, H. & Zhang, J-T., Jul 2008, In : Journal of Pharmacology and Experimental Therapeutics. 326, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

Mutagenesis
Disulfides
Cysteine
ATP-Binding Cassette Transporters
Multiple Drug Resistance
45 Citations (Scopus)

Human DNA polymerase η activity and translocation is regulated by phosphorylation

Chen, Y. W., Cleaver, J. E., Hatahet, Z., Honkanen, R. E., Chang, J. Y., Yen, Y. & Chou, K. M., Oct 28 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16578-16583 6 p.

Research output: Contribution to journalArticle

gemcitabine
DNA-Directed DNA Polymerase
Phosphorylation
Cisplatin
Protein Interaction Domains and Motifs
82 Citations (Scopus)

Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons

Jiang, Y., Guo, C., Vasko, M. & Kelley, M., Aug 1 2008, In : Cancer Research. 68, 15, p. 6425-6434 10 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Spinal Ganglia
Cisplatin
Oxygen
Neurons
87 Citations (Scopus)

Intrinsic disorder in pathogenic and non-pathogenic microbes: Discovering and analyzing the unfoldomes of early-branching eukaryotes

Mohan, A., Sullivan, W., Radivojac, P., Dunker, A. & Uversky, V. N., 2008, In : Molecular BioSystems. 4, 4, p. 328-340 13 p.

Research output: Contribution to journalArticle

Eukaryota
Proteome
Proteins
Genes
Intrinsically Disordered Proteins
4 Citations (Scopus)

L-DOPA-induced activation of striatal p38MAPK and CREB in neonatal dopaminergic denervated rat: Relevance to self-injurious behavior

Sivam, S., Pugazhenthi, S., Pugazhenthi, V. & Brown, H., Feb 1 2008, In : Journal of Neuroscience Research. 86, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Self-Injurious Behavior
Dihydroxyphenylalanine
Dopamine
Serotonin
36 Citations (Scopus)

Measurements of mitochondrial pH in cultured cortical neurons clarify contribution of mitochondrial pore to the mechanism of glutamate-induced delayed Ca2+ deregulation

Bolshakov, A. P., Mikhailova, M. M., Szabadkai, G., Pinelis, V. G., Broustovetski, N., Rizzuto, R. & Khodorov, B. I., Jun 2008, In : Cell Calcium. 43, 6, p. 602-614 13 p.

Research output: Contribution to journalArticle

Glutamic Acid
Calcium
Neurons
Strontium
mitochondrial permeability transition pore
33 Citations (Scopus)
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
Benzaldehydes
Quinazolines
10 Citations (Scopus)

Nerve growth factor, sphingomyelins, and sensitization in sensory neurons

Nicol, G., Oct 25 2008, In : Sheng li xue bao : [Acta physiologica Sinica]. 60, 5, p. 603-604 2 p.

Research output: Contribution to journalArticle

Sphingomyelins
Nerve Growth Factor
Sensory Receptor Cells
Ceramides
Sphingosine
59 Citations (Scopus)

N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons

Rimmerman, N., Bradshaw, H. B., Hughes, H. V., Chen, J. S. C., Hu, S. S. J., McHugh, D., Vefring, E., Jahnsen, J. A., Thompson, E. L., Masuda, K., Cravatt, B. F., Burstein, S., Vasko, M., Prieto, A. L., O'Dell, D. K. & Walker, J. M., Jul 2008, In : Molecular Pharmacology. 74, 1, p. 213-224 12 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Glycine
Nitric Oxide
Lipids
Calcium
16 Citations (Scopus)

Oligomeric BAX induces mitochondrial permeability transition and complete cytochrome c release without oxidative stress

Li, T., Brustovetsky, T., Antonsson, B. & Broustovetski, N., Nov 2008, In : Biochimica et Biophysica Acta - Bioenergetics. 1777, 11, p. 1409-1421 13 p.

Research output: Contribution to journalArticle

Oxidative stress
Cytochromes c
Alamethicin
Permeability
Mitochondrial Swelling
85 Citations (Scopus)

Paroxysmal extreme pain disorder M1627K mutation in human Nav 1.7 renders DRG neurons hyperexcitable

Dib-Hajj, S. D., Estacion, M., Jarecki, B. W., Tyrrell, L., Fischer, T. Z., Lawden, M., Cummins, T. & Waxman, S. G., Sep 19 2008, In : Molecular Pain. 4, 37.

Research output: Contribution to journalArticle

Diagnosis-Related Groups
Neurons
Mutation
Pain
NAV1.7 Voltage-Gated Sodium Channel
58 Citations (Scopus)

Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation

Jarecki, B. W., Sheets, P., Jackson, J. O. & Cummins, T., 2008, In : Journal of Physiology. 586, 17, p. 4137-4153 17 p.

Research output: Contribution to journalArticle

Mutation
NAV1.7 Voltage-Gated Sodium Channel
Paroxysmal Extreme Pain Disorder
Somatoform Disorders
Missense Mutation
4 Citations (Scopus)

Preparation and evaluation of a high-strength biocompatible glass-ionomer cement for improved dental restoratives.

Xie, D., Zhao, J., Yang, Y., Park, J., Chu, T. M. G. & Zhang, J-T., Jun 2008, In : Biomedical Materials (Bristol). 3, 2, p. 25012 1 p.

Research output: Contribution to journalArticle

Glass Ionomer Cements
Ionomers
Compressive Strength
Tooth
Cements
2 Citations (Scopus)

Recombinant bovine dihydrofolate reductase produced by mutagenesis and nested PCR of murine dihydrofolate reductase cDNA

Cody, V., Mao, Q. & Queener, S., Nov 2008, In : Protein Expression and Purification. 62, 1, p. 104-110 7 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Mutagenesis
Complementary DNA
Polymerase Chain Reaction
Liver
4 Citations (Scopus)

Silencing S1P1 receptors regulates collagen-V reactive lymphocyte-mediated immunobiology in the transplanted lung

Chiyo, M., Iwata, T., Webb, T. J., Vasko, M., Thompson, E. L., Heidler, K. M., Cummings, O., Yoshida, S., Fujisawa, T., Brand, D. D. & Wilkes, D. S., Mar 2008, In : American Journal of Transplantation. 8, 3, p. 537-546 10 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Collagen
Lymphocytes
Lung
Small Interfering RNA
33 Citations (Scopus)

Spinal N-methyl-d-aspartate receptors and nociception-evoked release of primary afferent substance P

Nazarian, A., Gu, G., Gracias, N. G., Wilkinson, K., Hua, X. Y., Vasko, M. & Yaksh, T. L., Mar 3 2008, In : Neuroscience. 152, 1, p. 119-127 9 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Nociception
Substance P
Aspartic Acid
Formaldehyde
36 Citations (Scopus)

Stress response pathways in protozoan parasites

Vonlaufen, N., Kanzok, S. M., Wek, R. & Sullivan, W., 2008, In : Cellular Microbiology. 10, 12, p. 2387-2399 13 p.

Research output: Contribution to journalArticle

Life Cycle Stages
Parasites
Apicomplexa
Drug Resistance
Cues
111 Citations (Scopus)

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain II voltage sensor in the closed configuration

Xiao, Y., Bingham, J. P., Zhu, W., Moczydlowski, E., Liang, S. & Cummins, T., Oct 3 2008, In : Journal of Biological Chemistry. 283, 40, p. 27300-27313 14 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Sodium Channels
Depolarization
Sensors
Electric potential
27 Citations (Scopus)
Furans
Folic Acid Antagonists
Toxoplasma
Bioactivity
Inhibitory Concentration 50
68 Citations (Scopus)

The transcription of bradyzoite genes in Toxoplasma gondii is controlled by autonomous promoter elements

Behnke, M. S., Radke, J. B., Smith, A. T., Sullivan, W. & White, M. W., Jun 2008, In : Molecular Microbiology. 68, 6, p. 1502-1518 17 p.

Research output: Contribution to journalArticle

Toxoplasma
Parasites
Luciferases
Gene Expression
Nucleoside-Triphosphatase
23 Citations (Scopus)
Embryonic Stem Cells
Neurons
Genes
Sensory Ganglia
T-Cell Leukemia
6 Citations (Scopus)
Death Domain Receptors
HL-60 Cells
Adenoviridae
Apoptosis
Acute Myeloid Leukemia
71 Citations (Scopus)

Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii

Narasimhan, J., Joyce, B. R., Naguleswaran, A., Smith, A. T., Livingston, M. R., Dixon, S. E., Coppens, I., Wek, R. & Sullivan, W., Jun 13 2008, In : Journal of Biological Chemistry. 283, 24, p. 16591-16601 11 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Toxoplasma
Cysts
Phosphotransferases
Apicomplexa
111 Citations (Scopus)

Use of non-mammalian alternative models for neurotoxicological study.

Peterson, R. T., Nass, R., Boyd, W. A., Freedman, J. H., Dong, K. & Narahashi, T., May 2008, In : NeuroToxicology. 29, 3, p. 546-555 10 p.

Research output: Contribution to journalArticle

Toxicology
International Agencies
Government Agencies
Cockroaches
Federal Government
2007
39 Citations (Scopus)

Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I

Zhu, W., Xu, P., Cuascut, F. X., Hall, A. K. & Oxford, G. S., Dec 12 2007, In : Journal of Neuroscience. 27, 50, p. 13770-13780 11 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Activins
Hyperalgesia
Spinal Ganglia
Sensory Receptor Cells
122 Citations (Scopus)

A Nav 1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity

Sheets, P., Jackson, J. O., Waxman, S. G., Dib-hajj, S. D. & Cummins, T., Jun 1 2007, In : Journal of Physiology. 581, 3, p. 1019-1031 13 p.

Research output: Contribution to journalArticle

Erythromelalgia
Lidocaine
Mutation
Local Anesthetics
Binding Sites
28 Citations (Scopus)

A novel comonomer-free light-cured glass-ionomer cement for reduced cytotoxicity and enhanced mechanical strength

Xie, D., Yang, Y., Zhao, J., Park, J. G. & Zhang, J-T., Aug 2007, In : Dental Materials. 23, 8, p. 994-1003 10 p.

Research output: Contribution to journalArticle

Glass Ionomer Cements
Ionomers
Cytotoxicity
carbopol 940
Strength of materials
25 Citations (Scopus)

ATP-sensitive potassium currents reduce the PGE2-mediated enhancement of excitability in adult rat sensory neurons

Chi, X. X., Jiang, X. & Nicol, G., May 11 2007, In : Brain Research. 1145, 1, p. 28-40 13 p.

Research output: Contribution to journalArticle

Diazoxide
Sensory Receptor Cells
Dinoprostone
Potassium
Adenosine Triphosphate
13 Citations (Scopus)

Biochemistry and pharmacology of the human multidrug resistance gene product, ABCG2

Zhang, J-T., Aug 2007, In : Journal of Central South University (Medical Sciences). 32, 4, p. 531-541 11 p.

Research output: Contribution to journalArticle

MDR Genes
Neoplastic Stem Cells
Biochemistry
Pharmacology
ATP-Binding Cassette Transporters
98 Citations (Scopus)

c-Jun promotes cellular survival by suppression of PTEN

Hettinger, K., Vikhanskaya, F., Poh, M. K., Lee, M. K., de Belle, I., Zhang, J-T., Reddy, S. A. G. & Sabapathy, K., Feb 2007, In : Cell Death and Differentiation. 14, 2, p. 218-229 12 p.

Research output: Contribution to journalArticle

Transcription Factor AP-1
Survival
Tumor Cell Line
Small Interfering RNA
Cell Survival
192 Citations (Scopus)

Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino- 5-ethylpyrrolo[2,3-d]pyrimidines as antifolates

Gangjee, A., Zeng, Y., Talreja, T., McGuire, J. J., Kisliuk, R. L. & Queener, S., Jun 28 2007, In : Journal of Medicinal Chemistry. 50, 13, p. 3046-3053 8 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pyrimidines
Sulfhydryl Compounds
Glutamic Acid
Saponification
163 Citations (Scopus)
DNA Repair
Neurons
DNA Damage
Mitochondrial DNA
Reactive Oxygen Species
188 Citations (Scopus)

From genes to pain: Nav1.7 and human pain disorders

Dib-Hajj, S. D., Cummins, T., Black, J. A. & Waxman, S. G., Nov 2007, In : Trends in Neurosciences. 30, 11, p. 555-563 9 p.

Research output: Contribution to journalArticle

Somatoform Disorders
Pain
Genes
Voltage-Gated Sodium Channels
Neurons
33 Citations (Scopus)

Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy

Xu, J., Peng, H. & Zhang, J-T., Mar 2007, In : Current Medicinal Chemistry. 14, 6, p. 689-701 13 p.

Research output: Contribution to journalArticle

Chemotherapy
Drug Resistance
Drug Therapy
Multiple Drug Resistance
Pharmaceutical Preparations
40 Citations (Scopus)

Lithium desensitizes brain mitochondria to calcium, antagonizes permeability transition, and diminishes cytochrome c release

Shalbuyeva, N., Brustovetsky, T. & Broustovetski, N., Jun 22 2007, In : Journal of Biological Chemistry. 282, 25, p. 18057-18068 12 p.

Research output: Contribution to journalArticle

Mitochondria
Cytochromes c
Lithium
Permeability
Brain
40 Citations (Scopus)

Manipulation of the potassium channel Kv1.1 and its effect on neuronal excitability in rat sensory neurons

Xian, X. C. & Nicol, G., Nov 2007, In : Journal of Neurophysiology. 98, 5, p. 2683-2692 10 p.

Research output: Contribution to journalArticle

Kv1.1 Potassium Channel
Sensory Receptor Cells
Small Interfering RNA
Action Potentials
Architectural Accessibility
12 Citations (Scopus)

Melatonin as a principal component of red light therapy

Yeager, R. L., Oleske, D. A., Sanders, R. A., Watkins, J. B., Eells, J. T. & Henshel, D. S., 2007, In : Medical Hypotheses. 69, 2, p. 372-376 5 p.

Research output: Contribution to journalArticle

Phototherapy
Melatonin
Free Radicals
Immune System
Research Personnel
72 Citations (Scopus)

Molecular interactions of the gating modifier toxin ProTx-II with Na v1.5: Implied existence of a novel toxin binding site coupled to activation

Smith, J. J., Cummins, T., Alphy, S. & Blumenthal, K. M., Apr 27 2007, In : Journal of Biological Chemistry. 282, 17, p. 12687-12697 11 p.

Research output: Contribution to journalArticle

Molecular interactions
Neurotoxins
Cystine Knot Motifs
Chemical activation
Binding Sites
25 Citations (Scopus)

Molecular tools for analysis of gene function in parasitic microorganisms

Meissner, M., Agop-Nersesian, C. & Sullivan, W., Jul 2007, In : Applied Microbiology and Biotechnology. 75, 5, p. 963-975 13 p.

Research output: Contribution to journalArticle

Microorganisms
Parasites
Genes
Protozoa
Parasitology
253 Citations (Scopus)

Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons

Rush, A. M., Cummins, T. & Waxman, S. G., Feb 15 2007, In : Journal of Physiology. 579, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

Sodium Channels
Spinal Ganglia
Protein Isoforms
Neurons
Diagnosis-Related Groups
49 Citations (Scopus)

Novel boron-containing, nonclassical antifolates: Synthesis and preliminary biological and structural evaluation

Reynolds, R. C., Campbell, S. R., Fairchild, R. G., Kisliuk, R. L., Micca, P. L., Queener, S., Riordan, J. M., Sedwick, W. D., Waud, W. R., Leung, A. K. W., Dixon, R. W., Suling, W. J. & Borhani, D. W., Jul 12 2007, In : Journal of Medicinal Chemistry. 50, 14, p. 3283-3289 7 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Boron
Lactobacillus casei
Tumors
Mycobacterium avium