Pharmacology & Toxicology

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2000

Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate

Cody, V., Chan, D., Galitsky, N., Rak, D., Luft, J. R., Pangborn, W., Queener, S. F., Laughton, C. A. & Stevens, M. F. G., Apr 4 2000, In : Biochemistry. 39, 13, p. 3556-3564 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
14 Scopus citations

Voltage-dependent ion channels in CAD cells: A catecholaminergic neuronal line that exhibits inducible differentiation

Wang, H. & Oxford, G. S., Dec 27 2000, In : Journal of Neurophysiology. 84, 6, p. 2888-2895 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
2001

Changes in the kinetic parameters of hepatic γ-glutamyltransferase from streptozotocin-induced diabetic rats

Cornwell, P. D. & Watkins, J. B., Feb 9 2001, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1545, 1-2, p. 184-191 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Characterization of oxidative stress in various tissues of diabetic and galactose-fed rats

Strother, R. M., Thomas, T. G., Otsyula, M., Sanders, R. A. & Watkins, J. B., Jan 1 2001, In : International Journal of Experimental Diabetes Research. 2, 3, p. 211-216 6 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Conformationally restricted tricyclic analogues of lipophilic pyrido[2, 3-d]pyrimidine antifolates [1a, b]

Gangjee, A., Mavandadi, F. & Queener, S. F., Jan 1 2001, In : Journal of Heterocyclic Chemistry. 38, 1, p. 213-220 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from pneumocystis carinii

Graffner-Nordberg, M., Kolmodin, K., Åqvist, J., Queener, S. F. & Hallberg, A., Jul 19 2001, In : Journal of Medicinal Chemistry. 44, 15, p. 2391-2402 12 p.

Research output: Contribution to journalArticle

84 Scopus citations

Differential splicing of Pneumocystis carinii f. sp. carinii inosine 5′-monophosphate dehydrogenase pre-mRNA

Ye, D., Lee, C. H. & Queener, S. F., Jan 24 2001, In : Gene. 263, 1-2, p. 151-158 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Effects of coenzyme Q10 treatment on antioxidant pathways in normal and streptozotocin-induced diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., Feb 19 2001, In : Journal of Biochemical and Molecular Toxicology. 15, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

85 Scopus citations

Effects of isoeugenol on oxidative stress pathways in normal and streptozotocin-induced diabetic rats

Rauscher, F. M., Sanders, R. A. & Watkins, J. B., Jun 19 2001, In : Journal of Biochemical and Molecular Toxicology. 15, 3, p. 159-164 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Effects of Quercetin on antioxidant defense in streptozotocin-induced diabetic rats

Sanders, R. A., Rauscher, F. M. & Watkins, J. B., Jun 19 2001, In : Journal of Biochemical and Molecular Toxicology. 15, 3, p. 143-149 7 p.

Research output: Contribution to journalArticle

122 Scopus citations

Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation

Kuzhikandathil, E. V., Wang, H., Szabo, T., Morozova, N., Blumberg, P. M. & Oxford, G. S., Nov 15 2001, In : Journal of Neuroscience. 21, 22, p. 8697-8706 10 p.

Research output: Contribution to journalArticle

103 Scopus citations

Identification of a 170-kDa protein over-expressed in lung cancers

Pincheira, R., Chen, Q. & Zhang, J. T., Jun 1 2001, In : British Journal of Cancer. 84, 11, p. 1520-1527 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Impact of the basic amine on the biological activity and intracellular distribution of an aza-anthrapyrazole: BBR 3422

Chou, K. M., Paul Krapcho, A. & Hacker, M. P., Dec 15 2001, In : Biochemical Pharmacology. 62, 10, p. 1337-1343 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

N,N′-Bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents

Huang, T. L., Tao, B., Quarshie, Y., Queener, S. F. & Donkor, I. O., Oct 22 2001, In : Bioorganic and Medicinal Chemistry Letters. 11, 20, p. 2679-2681 3 p.

Research output: Contribution to journalArticle

17 Scopus citations

Nav1.3 sodium channels: Rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons

Cummins, T. R., Aglieco, F., Renganathan, M., Herzog, R. I., Dib-Hajj, S. D. & Waxman, S. G., Aug 15 2001, In : Journal of Neuroscience. 21, 16, p. 5952-5961 10 p.

Research output: Contribution to journalArticle

Open Access
235 Scopus citations

Phorbol ester-induced inhibition of potassium currents in rat sensory neurons requires voltage-dependent entry of calcium

Zhang, Y. H., Kenyon, J. L. & Nicol, G. D., Jan 31 2001, In : Journal of Neurophysiology. 85, 1, p. 362-373 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
154 Scopus citations
20 Scopus citations

Sucrase-isomaltase: An epithelial chloride channel? [1] (multiple letters)

Danielsen, E. M., Sjöström, H., Norén, O., Danielsen, G. M., Finn, A. L. & Oxford, G. S., Jan 1 2001, In : Gastroenterology. 121, 3, p. 741-742 2 p.

Research output: Contribution to journalArticle

Sucrase-isomaltase is and adenosine 3′, 5′-cyclic monophosphate-dependent epithelial chloride channel

Finn, A. L., Kuzhikandathil, E. V., Oxford, G. S. & Itoh-Lindstrom, Y., Jan 2001, In : Gastroenterology. 120, 1, p. 117-125 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines

Gangjee, A., Vidwans, A., Elzein, E., McGuire, J. J., Queener, S. F. & Kisliuk, R. L., Jun 7 2001, In : Journal of Medicinal Chemistry. 44, 12, p. 1993-2003 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

Synthesis of 2,4-Diamino-6-(thioarylmethyl)pyrido[2,3-d]pyrimidines as dihydrofolate reductase inhibitors

Gangjee, A., Adair, O. & Queener, S. F., Oct 9 2001, In : Bioorganic and Medicinal Chemistry. 9, 11, p. 2929-2935 7 p.

Research output: Contribution to journalArticle

38 Scopus citations
13 Scopus citations

Two subcellular localizations of eIF3 p170 and its interaction with membrane-bound microfilaments: Implications for alternative functions of p170

Pincheira, R., Chen, Q., Huang, Z. & Zhang, J. T., Jan 1 2001, In : European Journal of Cell Biology. 80, 6, p. 410-418 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

β2-microglobulin induces apoptosis in HL-60 human leukemia cell line and its multidrug resistant variants overexpressing MRP1 but lacking Bax or overexpressing P-glycoprotein

Wu, C. H., Rastegar, M., Gordon, J. & Safa, A. R., Oct 25 2001, In : Oncogene. 20, 48, p. 7006-7020 15 p.

Research output: Contribution to journalArticle

24 Scopus citations
2002

An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3′ mispaired DNA

Chou, K. M. & Cheng, Y. C., Feb 7 2002, In : Nature. 415, 6872, p. 655-659 5 p.

Research output: Contribution to journalArticle

175 Scopus citations

cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation

Bhave, G., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S. & Gereau IV, R. W., Aug 15 2002, In : Neuron. 35, 4, p. 721-731 11 p.

Research output: Contribution to journalArticle

418 Scopus citations
132 Scopus citations

Characterization of anthracenediones and their photoaffinity analogs

Chou, K. M., Krapcho, A. P., Horn, D. & Hacker, M., Mar 15 2002, In : Biochemical Pharmacology. 63, 6, p. 1143-1147 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
66 Scopus citations

Cytoplasmic retraction of the amino terminus of human multidrug resistance protein 1

Chen, Q., Yang, Y., Liu, Y., Han, B. & Zhang, J. T., Jul 23 2002, In : Biochemistry. 41, 29, p. 9052-9062 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Dimerization of human XPA and formation of XPA2-RPA protein complex

Yang, Z. G., Liu, Y., Mao, L. Y., Zhang, J. T. & Zou, Y., Oct 29 2002, In : Biochemistry. 41, 43, p. 13012-13020 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Effects of combined Quercetin and coenzyme Q10 treatment on oxidative stress in normal and diabetic rats

Coldiron, A. D., Sanders, R. A. & Watkins, J. B., Oct 23 2002, In : Journal of Biochemical and Molecular Toxicology. 16, 4, p. 197-202 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Effects of β-carotene on oxidative stress in normal and diabetic rats

Maritim, A., Dene, B. A., Sanders, R. A. & Watkins, J. B., Oct 23 2002, In : Journal of Biochemical and Molecular Toxicology. 16, 4, p. 203-208 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs

Kilts, J. D., Connery, H. S., Arrington, E. G., Lewis, M. M., Lawler, C. P., Oxford, G. S., O'Malley, K. L., Todd, R. D., Blake, B. L., Nichols, D. E. & Mailman, R. B., Jun 17 2002, In : Journal of Pharmacology and Experimental Therapeutics. 301, 3, p. 1179-1189 11 p.

Research output: Contribution to journalArticle

66 Scopus citations

Impairment of slow inactivation as a common mechanism for periodic paralysis in dIIS4-S5

Bendahhou, S., Cummins, T. R., Kula, R. W., Fu, Y. H. & Ptácek, L. J., Apr 23 2002, In : Neurology. 58, 8, p. 1266-1272 7 p.

Research output: Contribution to journalArticle

59 Scopus citations

Inclusion of a competency-based curriculum in medical pharmacology

Near, J. A., Bosin, T. R. & Watkins, J. B., Jun 26 2002, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 366, 1, p. 26-29 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
44 Scopus citations

Mechanism of β2- microglobulin-induced apoptosis in the K562 leukemia cell line, defective in major histocompatibility class 1

Wu, C. H., Gordon, J. D., Zhong, X. & Safa, A. R., Sep 1 2002, In : Anticancer Research. 22, 5, p. 2613-2621 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mechanisms of the release of anterogradely transported neurotrophin-3 from axon terminals

Wang, X., Butowt, R., Vasko, M. R. & Von Bartheld, C. S., Feb 1 2002, In : Journal of Neuroscience. 22, 3, p. 931-945 15 p.

Research output: Contribution to journalArticle

53 Scopus citations

Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

Nass, R., Hall, D. H., Miller, D. M. & Blakely, R. D., Mar 5 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 5, p. 3264-3269 6 p.

Research output: Contribution to journalArticle

245 Scopus citations

Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant

Wu, C. H., Gordon, J., Rastegar, M., Ogretmen, B. & Safa, A. R., Jan 1 2002, In : Oncogene. 21, 33, p. 5160-5174 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

Regulation of gene expression by internal ribosome entry sites or cryptic promoters: The eIF4G story

Han, B. & Zhang, J. T., Nov 1 2002, In : Molecular and cellular biology. 22, 21, p. 7372-7384 13 p.

Research output: Contribution to journalArticle

95 Scopus citations

Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1

Yang, Y., Chen, Q. & Zhang, J. T., Nov 15 2002, In : Journal of Biological Chemistry. 277, 46, p. 44268-44277 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Structural studies on bioactive compounds. Part 36: Design, synthesis and biological evaluation of pyrimethamine-based antifolates against Pneumocystis carinii

Chan, D. C. M., Laughton, C. A., Queener, S. F. & Stevens, M. F. G., Jul 23 2002, In : Bioorganic and Medicinal Chemistry. 10, 9, p. 3001-3010 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Twenty-four hour exposure to prostaglandin downregulates prostanoid receptor binding but does not alter PGE2-mediated sensitization of rat sensory neurons

Southall, M. D., Bolyard, L. A. & Vasko, M. R., Apr 27 2002, In : Pain. 96, 3, p. 285-296 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2003

7-Methyl trimethoprim analogues as inhibitors of the folate metabolizing enzymes

Gangjee, A., Lin, X. & Queener, S. F., Jan 1 2003, In : Journal of Heterocyclic Chemistry. 40, 3, p. 507-512 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes

Southall, M. D., Li, T., Gharibova, L. S., Pei, Y., Nicol, G. D. & Travers, J. B., Jan 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 304, 1, p. 217-222 6 p.

Research output: Contribution to journalArticle

238 Scopus citations