Pharmacology & Toxicology

Publications 1971 2020

Filter
Article
2006
26 Citations (Scopus)

P-glycoprotein enhances TRAIL-triggered apoptosis in multidrug resistant cancer cells by interacting with the death receptor DR5

Park, S. J., Wu, C. H., Choi, M. R., Najafi, F., Emami, A. & Safa, A., Jul 28 2006, In : Biochemical Pharmacology. 72, 3, p. 293-307 15 p.

Research output: Contribution to journalArticle

Death Domain Receptors
P-Glycoprotein
Cells
Apoptosis
Neoplasms
6 Citations (Scopus)
Corpus Striatum
Enkephalins
Oxidopamine
Dopamine Agonists
Substance P
30 Citations (Scopus)

Sensitizing hormone-refractory prostate cancer cells to drug treatment by targeting 14-3-3σ

Han, B., Xie, H., Chen, Q. & Zhang, J-T., Apr 2006, In : Molecular Cancer Therapeutics. 5, 4, p. 903-912 10 p.

Research output: Contribution to journalArticle

Drug Delivery Systems
Prostatic Neoplasms
Androgens
Hormones
Drug Resistance
60 Citations (Scopus)
Sensory Receptor Cells
G-Protein-Coupled Receptors
Architectural Accessibility
GTP-Binding Proteins
Action Potentials
3 Citations (Scopus)

Synthesis of 2,6-diamino-5-[(2-substituted phenylamino)ethyl]pyrimidin- 4(3H)-one as inhibitors of folate metabolizing enzymes

Gangjee, A., Wang, Y., Queener, S. & Kisliuk, R. L., Nov 2006, In : Journal of Heterocyclic Chemistry. 43, 6, p. 1523-1531 9 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Folic Acid
Escherichia coli
Aniline Compounds
Enzymes
19 Citations (Scopus)

The amino terminus of the human multidrug resistance transporter ABCC1 has a U-shaped folding with a gating function

Chen, Q., Yang, Y., Li, L. & Zhang, J-T., Oct 13 2006, In : Journal of Biological Chemistry. 281, 41, p. 31152-31163 12 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Multiple Drug Resistance
Cells
Chemotherapy
Extracellular Space
256 Citations (Scopus)

The Role of Sodium Channels in Chronic Inflammatory and Neuropathic Pain

Amir, R., Argoff, C. E., Bennett, G. J., Cummins, T., Durieux, M. E., Gerner, P., Gold, M. S., Porreca, F. & Strichartz, G. R., May 2006, In : Journal of Pain. 7, 5 SUPPL.

Research output: Contribution to journalArticle

Sodium Channels
Voltage-Gated Sodium Channels
Neuralgia
Chronic Pain
Sodium Channel Blockers
2007
39 Citations (Scopus)

Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I

Zhu, W., Xu, P., Cuascut, F. X., Hall, A. K. & Oxford, G. S., Dec 12 2007, In : Journal of Neuroscience. 27, 50, p. 13770-13780 11 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Activins
Hyperalgesia
Spinal Ganglia
Sensory Receptor Cells
122 Citations (Scopus)

A Nav 1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity

Sheets, P., Jackson, J. O., Waxman, S. G., Dib-hajj, S. D. & Cummins, T., Jun 1 2007, In : Journal of Physiology. 581, 3, p. 1019-1031 13 p.

Research output: Contribution to journalArticle

Erythromelalgia
Lidocaine
Mutation
Local Anesthetics
Binding Sites
29 Citations (Scopus)

A novel comonomer-free light-cured glass-ionomer cement for reduced cytotoxicity and enhanced mechanical strength

Xie, D., Yang, Y., Zhao, J., Park, J. G. & Zhang, J-T., Aug 2007, In : Dental Materials. 23, 8, p. 994-1003 10 p.

Research output: Contribution to journalArticle

Glass Ionomer Cements
Ionomers
Cytotoxicity
carbopol 940
Strength of materials
25 Citations (Scopus)

ATP-sensitive potassium currents reduce the PGE2-mediated enhancement of excitability in adult rat sensory neurons

Chi, X. X., Jiang, X. & Nicol, G., May 11 2007, In : Brain Research. 1145, 1, p. 28-40 13 p.

Research output: Contribution to journalArticle

Diazoxide
Sensory Receptor Cells
Dinoprostone
Potassium
Adenosine Triphosphate
13 Citations (Scopus)

Biochemistry and pharmacology of the human multidrug resistance gene product, ABCG2

Zhang, J-T., Aug 2007, In : Journal of Central South University (Medical Sciences). 32, 4, p. 531-541 11 p.

Research output: Contribution to journalArticle

MDR Genes
Neoplastic Stem Cells
Biochemistry
Pharmacology
ATP-Binding Cassette Transporters
98 Citations (Scopus)

c-Jun promotes cellular survival by suppression of PTEN

Hettinger, K., Vikhanskaya, F., Poh, M. K., Lee, M. K., de Belle, I., Zhang, J-T., Reddy, S. A. G. & Sabapathy, K., Feb 2007, In : Cell Death and Differentiation. 14, 2, p. 218-229 12 p.

Research output: Contribution to journalArticle

Transcription Factor AP-1
Survival
Tumor Cell Line
Small Interfering RNA
Cell Survival
192 Citations (Scopus)

Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino- 5-ethylpyrrolo[2,3-d]pyrimidines as antifolates

Gangjee, A., Zeng, Y., Talreja, T., McGuire, J. J., Kisliuk, R. L. & Queener, S., Jun 28 2007, In : Journal of Medicinal Chemistry. 50, 13, p. 3046-3053 8 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pyrimidines
Sulfhydryl Compounds
Glutamic Acid
Saponification
163 Citations (Scopus)
DNA Repair
Neurons
DNA Damage
Mitochondrial DNA
Reactive Oxygen Species
188 Citations (Scopus)

From genes to pain: Nav1.7 and human pain disorders

Dib-Hajj, S. D., Cummins, T., Black, J. A. & Waxman, S. G., Nov 2007, In : Trends in Neurosciences. 30, 11, p. 555-563 9 p.

Research output: Contribution to journalArticle

Somatoform Disorders
Pain
Genes
Voltage-Gated Sodium Channels
Neurons
33 Citations (Scopus)

Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy

Xu, J., Peng, H. & Zhang, J-T., Mar 2007, In : Current Medicinal Chemistry. 14, 6, p. 689-701 13 p.

Research output: Contribution to journalArticle

Chemotherapy
Drug Resistance
Drug Therapy
Multiple Drug Resistance
Pharmaceutical Preparations
41 Citations (Scopus)

Lithium desensitizes brain mitochondria to calcium, antagonizes permeability transition, and diminishes cytochrome c release

Shalbuyeva, N., Brustovetsky, T. & Broustovetski, N., Jun 22 2007, In : Journal of Biological Chemistry. 282, 25, p. 18057-18068 12 p.

Research output: Contribution to journalArticle

Mitochondria
Cytochromes c
Lithium
Permeability
Brain
40 Citations (Scopus)

Manipulation of the potassium channel Kv1.1 and its effect on neuronal excitability in rat sensory neurons

Xian, X. C. & Nicol, G., Nov 2007, In : Journal of Neurophysiology. 98, 5, p. 2683-2692 10 p.

Research output: Contribution to journalArticle

Kv1.1 Potassium Channel
Sensory Receptor Cells
Small Interfering RNA
Action Potentials
Architectural Accessibility
12 Citations (Scopus)

Melatonin as a principal component of red light therapy

Yeager, R. L., Oleske, D. A., Sanders, R. A., Watkins, J. B., Eells, J. T. & Henshel, D. S., 2007, In : Medical Hypotheses. 69, 2, p. 372-376 5 p.

Research output: Contribution to journalArticle

Phototherapy
Melatonin
Free Radicals
Immune System
Research Personnel
74 Citations (Scopus)

Molecular interactions of the gating modifier toxin ProTx-II with Na v1.5: Implied existence of a novel toxin binding site coupled to activation

Smith, J. J., Cummins, T., Alphy, S. & Blumenthal, K. M., Apr 27 2007, In : Journal of Biological Chemistry. 282, 17, p. 12687-12697 11 p.

Research output: Contribution to journalArticle

Molecular interactions
Neurotoxins
Cystine Knot Motifs
Chemical activation
Binding Sites
25 Citations (Scopus)

Molecular tools for analysis of gene function in parasitic microorganisms

Meissner, M., Agop-Nersesian, C. & Sullivan, W., Jul 2007, In : Applied Microbiology and Biotechnology. 75, 5, p. 963-975 13 p.

Research output: Contribution to journalArticle

Microorganisms
Parasites
Genes
Protozoa
Parasitology
254 Citations (Scopus)

Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons

Rush, A. M., Cummins, T. & Waxman, S. G., Feb 15 2007, In : Journal of Physiology. 579, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

Sodium Channels
Spinal Ganglia
Protein Isoforms
Neurons
Diagnosis-Related Groups
49 Citations (Scopus)

Novel boron-containing, nonclassical antifolates: Synthesis and preliminary biological and structural evaluation

Reynolds, R. C., Campbell, S. R., Fairchild, R. G., Kisliuk, R. L., Micca, P. L., Queener, S., Riordan, J. M., Sedwick, W. D., Waud, W. R., Leung, A. K. W., Dixon, R. W., Suling, W. J. & Borhani, D. W., Jul 12 2007, In : Journal of Medicinal Chemistry. 50, 14, p. 3283-3289 7 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Boron
Lactobacillus casei
Tumors
Mycobacterium avium
50 Citations (Scopus)

Oligomerization domain of the multidrug resistance-associated transporter ABCG2 and its dominant inhibitory activity

Xu, J., Peng, H., Chen, Q., Liu, Y., Dong, Z. & Zhang, J-T., May 1 2007, In : Cancer Research. 67, 9, p. 4373-4381 9 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Drug Resistance
ATP-Binding Cassette Transporters
HEK293 Cells
Neoplasms
9 Citations (Scopus)

Painful research: Identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels

Rush, A. M. & Cummins, T., Aug 2007, In : Molecular Interventions. 7, 4, p. 192-195 4 p.

Research output: Contribution to journalArticle

Aniline Compounds
Sodium Channel Blockers
Furans
Sodium Channels
Neurons
114 Citations (Scopus)

Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1

Zhu, W. & Oxford, G. S., Apr 2007, In : Molecular and Cellular Neuroscience. 34, 4, p. 689-700 12 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Nerve Growth Factor
Mitogen-Activated Protein Kinases
Diagnosis-Related Groups
Capsaicin
11 Citations (Scopus)
DNA-Activated Protein Kinase
RNA Helicases
Phosphorylation
Multiple Drug Resistance
P-Glycoprotein
27 Citations (Scopus)

Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii

Smith, A. T., Livingston, M. R., Mai, A., Filetici, P., Queener, S. & Sullivan, W., Mar 2007, In : Antimicrobial Agents and Chemotherapy. 51, 3, p. 1109-1111 3 p.

Research output: Contribution to journalArticle

Histone Acetyltransferases
Toxoplasma
Apicoplasts
Plastids
Organelles
38 Citations (Scopus)

Regulation of function by dimerization through the amino-terminal membrane-spanning domain of human ABCC1/MRP1

Yang, Y., Liu, Y., Dong, Z., Xu, J., Peng, H., Liu, Z. & Zhang, J-T., Mar 23 2007, In : Journal of Biological Chemistry. 282, 12, p. 8821-8830 10 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Dimerization
Membranes
Chemotherapy
Nucleotides
15 Citations (Scopus)

Role of calcium in volume-activated chloride currents in a mouse cholangiocyte cell line

Chen, B., Nicol, G. & Cho, W. K., Jan 2007, In : Journal of Membrane Biology. 215, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Chlorides
Calcium
Cell Line
Bile Ducts
Chloride Channels
36 Citations (Scopus)

Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development

Liu, Z., Dong, Z., Yang, Z., Chen, Q., Pan, Y., Yang, Y., Cui, P., Zhang, X. & Zhang, J-T., Sep 2007, In : Differentiation. 75, 7, p. 652-661 10 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
Cell Differentiation
Epithelial Cells
Protein Biosynthesis
RNA Interference
24 Citations (Scopus)
Ion Channel Gating
Sodium Channel Blockers
Protein Conformation
Muscle Proteins
Sodium Channels
14 Citations (Scopus)

Suppression of endogenous antioxidant enzymes by 2,3,7,8- tetrachlorodibenzo-p-dioxin-induced oxidative stress in chicken liver during development

Lim, J., DeWitt, J. C., Sanders, R. A., Watkins, J. B. & Henshel, D. S., May 2007, In : Archives of Environmental Contamination and Toxicology. 52, 4, p. 590-595 6 p.

Research output: Contribution to journalArticle

Oxidative stress
Antioxidants
Liver
dioxin
antioxidant
323 Citations (Scopus)

The roles of sodium channels in nociception: Implications for mechanisms of pain

Cummins, T., Sheets, P. & Waxman, S. G., Oct 2007, In : Pain. 131, 3, p. 243-257 15 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Nociception
Sodium Channels
Pain
Sensory Receptor Cells
113 Citations (Scopus)
Nociceptors
Nerve Growth Factor
Sensory Receptor Cells
Neurons
Nerve Growth Factor Receptors
32 Citations (Scopus)
ATP-Binding Cassette Transporters
Drug Resistance
Drug Therapy
Multiple Drug Resistance
Neoplasms
42 Citations (Scopus)

Use of comparative proteomics to identify potential resistance mechanisms in cancer treatment

Zhang, J-T. & Liu, Y., Dec 2007, In : Cancer Treatment Reviews. 33, 8, p. 741-756 16 p.

Research output: Contribution to journalArticle

Proteomics
Drug Resistance
Neoplasms
Cell Line
Therapeutics
42 Citations (Scopus)

Voltage-gated sodium channel blockers for the treatment of neuropathic pain

Cummins, T. & Rush, A. M., Nov 2007, In : Expert Review of Neurotherapeutics. 7, 11, p. 1597-1612 16 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channel Blockers
Neuralgia
Sodium Channel Blockers
Sodium Channels
Pain
2008
8 Citations (Scopus)

Analysis of changes in the proteome of HL-60 promyeloid leukemia cells induced by the proteasome inhibitor PSI

Choi, M. R., Najafi, F., Safa, A. & Drexler, H. C. A., Jun 15 2008, In : Biochemical Pharmacology. 75, 12, p. 2276-2288 13 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Proteome
Leukemia
HL-60 Cells
Cells
105 Citations (Scopus)

A new mechanism of drug resistance in breast cancer cells: Fatty acid synthase overexpression-mediated palmitate overproduction

Liu, H., Liu, Y. & Zhang, J-T., Feb 1 2008, In : Molecular Cancer Therapeutics. 7, 2, p. 263-270 8 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Palmitates
Drug Resistance
Breast Neoplasms
Cell Line
10 Citations (Scopus)

Attenuation of TCDD-induced oxidative stress by 670 nm photobiomodulation in developmental chicken kidney

Lim, J., Sanders, R. A., Yeager, R. L., Millsap, D. S., Watkins, J. B., Eells, J. T. & Henshel, D. S., 2008, In : Journal of Biochemical and Molecular Toxicology. 22, 4, p. 230-239 10 p.

Research output: Contribution to journalArticle

Oxidative stress
Chickens
Oxidative Stress
Kidney
Lipid Peroxidation
14 Citations (Scopus)

Azurin-like protein blocks invasion of Toxoplasma gondii through potential interactions with parasite surface antigen SAG1

Naguleswaran, A., Fialho, A. M., Chaudhari, A., Chang, S. H., Chakrabarty, A. M. & Sullivan, W., Feb 2008, In : Antimicrobial Agents and Chemotherapy. 52, 2, p. 402-408 7 p.

Research output: Contribution to journalArticle

Azurin
Toxoplasma
Surface Antigens
Parasites
Proteins
36 Citations (Scopus)
Nerve Growth Factor Receptor
Sphingomyelins
Brain-Derived Neurotrophic Factor
Sensory Receptor Cells
Nerve Growth Factors
30 Citations (Scopus)

Caenorhabditis elegans in Parkinson's disease drug discovery: Addressing an unmet medical need

Nass, R., Merchant, K. M. & Ryan, T., Dec 1 2008, In : Molecular Interventions. 8, 6, p. 284-293 10 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Drug Discovery
Parkinson Disease
Lewy Bodies
Nerve Degeneration
134 Citations (Scopus)

Cellular FLICE-like inhibitory protein (C-FLIP): A novel target for cancer therapy

Safa, A., Day, T. W. & Wu, C. H., Feb 2008, In : Current Cancer Drug Targets. 8, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Staphylococcal Protein A
Neoplasms
Death Domain Receptor Signaling Adaptor Proteins
Caspase 8
57 Citations (Scopus)

c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells

Day, T. W., Huang, S. & Safa, A., Dec 15 2008, In : Biochemical Pharmacology. 76, 12, p. 1694-1704 11 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Caspase 9
Caspase 8
MCF-7 Cells
Cells
141 Citations (Scopus)
Voltage-Gated Sodium Channels
Carbamazepine
Lidocaine
Pain
Nociceptors
29 Citations (Scopus)

Effect of cysteine mutagenesis on the function and disulfide bond formation of human ABCG2

Liu, Y., Yang, Y., Qi, J., Peng, H. & Zhang, J-T., Jul 2008, In : Journal of Pharmacology and Experimental Therapeutics. 326, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

Mutagenesis
Disulfides
Cysteine
ATP-Binding Cassette Transporters
Multiple Drug Resistance
45 Citations (Scopus)

Human DNA polymerase η activity and translocation is regulated by phosphorylation

Chen, Y. W., Cleaver, J. E., Hatahet, Z., Honkanen, R. E., Chang, J. Y., Yen, Y. & Chou, K. M., Oct 28 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16578-16583 6 p.

Research output: Contribution to journalArticle

gemcitabine
DNA-Directed DNA Polymerase
Phosphorylation
Cisplatin
Protein Interaction Domains and Motifs