Pharmacology & Toxicology

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Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs

Kilts, J. D., Connery, H. S., Arrington, E. G., Lewis, M. M., Lawler, C. P., Oxford, G. S., O'Malley, K. L., Todd, R. D., Blake, B. L., Nichols, D. E. & Mailman, R. B., Jun 17 2002, In : Journal of Pharmacology and Experimental Therapeutics. 301, 3, p. 1179-1189 11 p.

Research output: Contribution to journalArticle

66 Scopus citations

Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel

Chen, X., Sun, W., Gianaris, N. G., Riley, A. M., Cummins, T. R., Fehrenbacher, J. C. & Obukhov, A. G., Apr 4 2014, In : Journal of Biological Chemistry. 289, 14, p. 9600-9610 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex

Wilson, S. M., Brittain, J. M., Piekarz, A. D., Ballard, C. J., Ripsch, M. S., Cummins, T. R., Hurley, J. H., Khanna, M., Hammes, N. M., Samuels, B. C., White, F. A. & Khanna, R., Jan 1 2011, In : Channels. 5, 5

Research output: Contribution to journalArticle

Open Access
33 Scopus citations
36 Scopus citations

Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons

Dib-Hajj, S. D., Rush, A. M., Cummins, T. R., Hisama, F. M., Novella, S., Tyrrell, L., Marshall, L. & Waxman, S. G., Aug 1 2005, In : Brain. 128, 8, p. 1847-1854 8 p.

Research output: Contribution to journalArticle

312 Scopus citations

Garcinol inhibits GCN5-mediated lysine acetyltransferase activity and prevents replication of the parasite Toxoplasma gondii

Jeffers, V., Gao, H., Checkley, L. A., Liu, Y., Ferdig, M. T. & Sullivan, W. J., Apr 2016, In : Antimicrobial Agents and Chemotherapy. 60, 4, p. 2164-2170 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins

Xiao, Y., Blumenthal, K. & Cummins, T. R., Aug 2014, In : Molecular pharmacology. 86, 2, p. 159-167 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

GBR-12909-induced self-injurious behavior: role of dopamine

Sivam, S. P., Sep 4 1995, In : Brain research. 690, 2, p. 259-263 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii

Konrad, C., Wek, R. C. & Sullivan, W. J., Feb 1 2014, In : International Journal for Parasitology. 44, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Genetic pathways, prevention, and treatment of sporadic colorectal cancer

Mundade, R., Imperiale, T. F., Prabhu, L., Loehrer, P. J. & Lu, T., Jan 1 2014, In : Oncoscience. 1, 6, p. 400-406 7 p.

Research output: Contribution to journalArticle

57 Scopus citations

Glial-derived neurotrophic factor upregulates expression of functional SNS and NaN sodium channels and their currents in axotomized dorsal root ganglion neurons

Cummins, T. R., Black, J. A., Dib-Hajj, S. D. & Waxman, S. G., Dec 1 2000, In : Journal of Neuroscience. 20, 23, p. 8754-8761 8 p.

Research output: Contribution to journalArticle

Open Access
125 Scopus citations

Global microRNA expression profiling of caenorhabditis elegans Parkinson's disease models

Asikainen, S., Rudgalvyte, M., Heikkinen, L., Louhiranta, K., Lakso, M., Wong, G. & Nass, R., May 1 2010, In : Journal of Molecular Neuroscience. 41, 1, p. 210-218 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

Glucose-independent acetate metabolism promotes melanoma cell survival and tumor growth

Lakhter, A. J., Hamilton, J., Konger, R., Broustovetski, N., Broxmeyer, H. & Naidu, S., Oct 14 2016, In : Journal of Biological Chemistry. 291, 42, p. 21869-21879 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Gonadal steroids in the treatment of mood disorders

Epperson, C. N., Wisner, K. L. & Yamamoto, B., 1999, In : Psychosomatic Medicine. 61, 5, p. 676-697 22 p.

Research output: Contribution to journalArticle

105 Scopus citations

Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding

Reilly, A. M., Zhou, S., Panigrahi, S. K., Yan, S., Conley, J. M., Sheets, P. L., Wardlaw, S. L. & Ren, H., Dec 1 2019, In : Nutrition and Diabetes. 9, 1, 29.

Research output: Contribution to journalArticle

Open Access

G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans

Wang, J., Luo, J., Aryal, D. K., Wetsel, W. C., Nass, R. & Benovic, J. L., Apr 7 2017, In : Journal of Biological Chemistry. 292, 14, p. 5943-5956 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis

Benmerzouga, I., Checkley, L. A., Ferdig, M. T., Arrizabalaga, G., Wek, R. C. & Sullivan, W. J., Nov 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6939-6945 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Guanabenz reverses a key behavioral change caused by latent toxoplasmosis in mice by reducing neuroinflammation

Martynowicz, J., Augusto, L., Wek, R. C., Boehm, S. L. & Sullivan, W. J., Mar 1 2019, In : mBio. 10, 2, e00381-19.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Guanine nucleotide binding proteins mediate D2 dopamine receptor activation of a potassium channel in rat lactotrophs.

Einhorn, L. C. & Oxford, G. S., Mar 1 1993, In : The Journal of Physiology. 462, 1, p. 563-578 16 p.

Research output: Contribution to journalArticle

34 Scopus citations

Heart rate control in normal and aborted-SIDS infants

Pincus, S. M., Cummins, T. R. & Haddad, G. G., 1993, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 264, 3 33-3, p. R638-R646

Research output: Contribution to journalArticle

196 Scopus citations

Hedgehog pathway activation alters ciliary signaling in primary hypothalamic cultures

Bansal, R., Engle, S. E., Antonellis, P. J., Whitehouse, L. S., Baucum, A. J., Cummins, T. R., Reiter, J. F. & Berbari, N. F., May 14 2019, In : Frontiers in Cellular Neuroscience. 13, 266.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
5 Scopus citations

Hepatic phase I and phase II biotransformations in quail and trout: Comparison to other species commonly used in toxicity testing

Gregus, Z., Watkins, J. B., Thompson, T. N., Harvey, M. J., Rozman, K. & Klaassen, C. D., Mar 15 1983, In : Toxicology and Applied Pharmacology. 67, 3, p. 430-441 12 p.

Research output: Contribution to journalArticle

95 Scopus citations

Hepatic phase II biotransformation in C57Bl/KsJ db/db mice: comparison to that in swiss webster and 129 REJ mice

Watkins, J. B. & klueber, K. M., 1988, In : Comparative Biochemistry and Physiology. Part C, Comparative. 90, 2, p. 417-421 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Hepatobiliary excretion of bile acids and rose bengal in streptozotocin- induced and genetic diabetic rats

Stone, J. L., Braunstein, J. B., Beaty, T. M., Sanders, R. A. & Watkins, J. B., May 24 1997, In : Journal of Pharmacology and Experimental Therapeutics. 281, 1, p. 412-419 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury

Omar, H. M., Sanders, R. A. & Watkins, J. B., Nov 7 1996, In : Inflammation Research. 45, 10, p. 519-523 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

High-dose methamphetamine acutely-activates the striatonigral pathway to increase striatal glutamate and mediate long-term dopamine toxicity

Mark, K. A., Soghomonian, J. J. & Yamamoto, B. K., Dec 15 2004, In : Journal of Neuroscience. 24, 50, p. 11449-11456 8 p.

Research output: Contribution to journalArticle

132 Scopus citations

Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala

Ferreira, A. N., Yousuf, H., Dalton, S. & Sheets, P. L., Apr 28 2015, In : Frontiers in Cellular Neuroscience. 9, APR, 161.

Research output: Contribution to journalArticle

16 Scopus citations

Histone acetylase GCN5 enters the nucleus via importin-α in protozoan parasite Toxoplasma gondii

Bhatti, M. M. & Sullivan, W. J., Feb 18 2005, In : Journal of Biological Chemistry. 280, 7, p. 5902-5908 7 p.

Research output: Contribution to journalArticle

33 Scopus citations
15 Scopus citations

Histone-modifying complexes regulate gene expression pertinent to the differentiation of the protozoan parasite Toxoplasma gondii

Saksouk, N., Bhatti, M. M., Kieffer, S., Smith, A. T., Musset, K., Garin, J., Sullivan, W. J., Cesbron-Delauw, M. F. & Hakimi, M. A., Dec 2005, In : Molecular and cellular biology. 25, 23, p. 10301-10314 14 p.

Research output: Contribution to journalArticle

124 Scopus citations

HIV and drug abuse mediate astrocyte senescence in a β-catenin-dependent manner leading to neuronal toxicity

Yu, C., Narasipura, S. D., Richards, M. H., Hu, X. T., Yamamoto, B. & Al-Harthi, L., Oct 2017, In : Aging Cell. 16, 5, p. 956-965 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Human ABCC1 interacts and colocalizes with ATP synthase α, revealed by interactive proteomics analysis

Yang, Y., Li, Z., Mo, W., Ambadipudi, R., Arnold, R. J., Hrncirova, P., Novotny, M. V., Georges, E. & Zhang, J. T., Feb 3 2012, In : Journal of Proteome Research. 11, 2, p. 1364-1372 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Human DNA polymerase η activity and translocation is regulated by phosphorylation

Chen, Y. W., Cleaver, J. E., Hatahet, Z., Honkanen, R. E., Chang, J. Y., Yen, Y. & Chou, K. M., Oct 28 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16578-16583 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Human dopamine D3 and D2L receptors couple to inward rectifier potassium channels in mammalian cell lines

Kuzhikandathil, E. V., Yu, W. & Oxford, G. S., Dec 1998, In : Molecular and Cellular Neurosciences. 12, 6, p. 390-402 13 p.

Research output: Contribution to journalArticle

84 Scopus citations
11 Scopus citations

Human neocortical excitability is decreased during anoxia via sodium channel modulation

Cummins, T. R., Jiang, C. & Haddad, G. G., Feb 1993, In : Journal of Clinical Investigation. 91, 2, p. 608-615 8 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

Jarecki, B. W., Piekarz, A. D., Jackson, J. O. & Cummins, T. R., Jan 4 2010, In : Journal of Clinical Investigation. 120, 1, p. 369-378 10 p.

Research output: Contribution to journalArticle

93 Scopus citations
18 Scopus citations

Hypertension incidence after tap-water implementation: A 13-year follow-up study in the arseniasis-endemic area of southwestern Taiwan

Wang, S. L., Li, W. F., Chen, C. J., Huang, Y. L., Chen, J. W., Chang, K. H., Tsai, L. Y. & Chou, K. M., Oct 1 2011, In : Science of the Total Environment. 409, 21, p. 4528-4535 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
22 Scopus citations
46 Scopus citations

Identification of 14-3-3σ as a contributor to drug resistance in human breast cancer cells using functional proteomic analysis

Liu, Y., Liu, H., Han, B. & Zhang, J. T., Mar 15 2006, In : Cancer Research. 66, 6, p. 3248-3255 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Identification of a 170-kDa protein over-expressed in lung cancers

Pincheira, R., Chen, Q. & Zhang, J. T., Jun 1 2001, In : British Journal of Cancer. 84, 11, p. 1520-1527 8 p.

Research output: Contribution to journalArticle

83 Scopus citations
Open Access
30 Scopus citations

Identification of fis1 interactors in Toxoplasma gondii reveals a novel protein required for peripheral distribution of the mitochondrion

Jacobs, K., Charvat, R. & Arrizabalaga, G., Jan 1 2020, In : mBio. 11, 1, e02732-19.

Research output: Contribution to journalArticle

Open Access

Identification of highly potent and selective inhibitors of Toxoplasma gondii dihydrofolate reductase

Chio, L. C. & Queener, S. F., 1993, In : Antimicrobial Agents and Chemotherapy. 37, 9, p. 1914-1923 10 p.

Research output: Contribution to journalArticle

Open Access
92 Scopus citations

Identification of novel small molecule inhibitors of the XPA protein using in silico based screening

Neher, T. M., Shuck, S. C., Liu, J. Y., Zhang, J. T. & Turchi, J. J., Oct 15 2010, In : ACS chemical biology. 5, 10, p. 953-965 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Identification of proteins interacting with Toxoplasma SRCAP by yeast two-hybrid screening

Nallani, K. C. & Sullivan, W. J., Mar 1 2005, In : Parasitology Research. 95, 4, p. 236-242 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Identification of the benzyloxyphenyl pharmacophore: A structural unit that promotes sodium channel slow inactivation

King, A. M., Yang, X. F., Wang, Y., Dustrude, E. T., Barbosa, C., Due, M. R., Piekarz, A. D., Wilson, S. M., White, F. A., Salomé, C., Cummins, T. R., Khanna, R. & Kohn, H., Dec 19 2012, In : ACS Chemical Neuroscience. 3, 12, p. 1037-1049 13 p.

Research output: Contribution to journalArticle

8 Scopus citations