Pharmacology & Toxicology

Publications 1971 2020

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5 Citations (Scopus)
Clorgyline
Selegiline
Dynorphins
Monoamine Oxidase Inhibitors
Monoamine Oxidase
29 Citations (Scopus)

Influence of treatment of diabetic rats with combinations of pycnogenol, β-carotene, and α-lipoic acid on parameters of oxidative stress

Berryman, A. M., Maritim, A. C., Sanders, R. A. & Watkins, J. B., 2004, In : Journal of Biochemical and Molecular Toxicology. 18, 6, p. 345-352 8 p.

Research output: Contribution to journalArticle

Thioctic Acid
Oxidative stress
Carotenoids
Rats
Oxidative Stress
22 Citations (Scopus)

Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency

Zhang, M., Gallego-Delgado, J., Fernandez-Arias, C., Waters, N. C., Rodriguez, A., Tsuji, M., Wek, R., Nussenzweig, V. & Sullivan, W., Dec 13 2017, In : Cell Host and Microbe. 22, 6, p. 766-776.e4

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Plasmodium
Phosphotransferases
Parasites
Phosphorylation
10 Citations (Scopus)
Pneumocystis carinii
Pyrimethamine
Tetrahydrofolate Dehydrogenase
Toxoplasma
Carbon
13 Citations (Scopus)

Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor

Sheets, P., Gerner, P., Wang, C. F., Wang, S. Y., Ging, K. W. & Cummins, T., Oct 2006, In : Journal of Neurophysiology. 96, 4, p. 1848-1859 12 p.

Research output: Contribution to journalArticle

Trifluoperazine
Sodium Channels
Local Anesthetics
Calmodulin
Inhibition (Psychology)
45 Citations (Scopus)

Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide

Theile, J. W. & Cummins, T., Oct 2011, In : Molecular Pharmacology. 80, 4, p. 724-734 11 p.

Research output: Contribution to journalArticle

Riluzole
Carbamazepine
Sodium
Erythromelalgia
Peptides
43 Citations (Scopus)
Pneumocystis carinii
Mycobacterium avium
Pyrimidines
Tetrahydrofolate Dehydrogenase
Trimethoprim
6 Citations (Scopus)
Trimetrexate
Pneumocystis
Pyrimethamine
Tetrahydrofolate Dehydrogenase
Pneumocystis carinii
16 Citations (Scopus)

Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain

François-Moutal, L., Dustrude, E. T., Wang, Y., Brustovetsky, T., Dorame, A., Ju, W., Moutal, A., Perez-Miller, S., Broustovetski, N., Gokhale, V., Khanna, M. & Khanna, R., Oct 1 2018, In : Pain. 159, 10, p. 2115-2127 13 p.

Research output: Contribution to journalArticle

Sumoylation
Neuralgia
Ubiquitin
Enzymes
Peptides
30 Citations (Scopus)

Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone

Isenberg, J. S., Kolaja, K. L., Ayoubi, S. A., Watkins, J. B. & Klaunig, J. E., Aug 1997, In : Carcinogenesis. 18, 8, p. 1511-1519 9 p.

Research output: Contribution to journalArticle

Rotenone
Liver
Growth
Diet
DNA
19 Citations (Scopus)

Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii

Konrad, C., Queener, S., Wek, R. & Sullivan, W., Apr 2013, In : Antimicrobial Agents and Chemotherapy. 57, 4, p. 1815-1822 8 p.

Research output: Contribution to journalArticle

Guanabenz
Eukaryotic Initiation Factor-2
Toxoplasma
Parasites
Phosphorylation
83 Citations (Scopus)

Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by α-adrenergic receptor antagonists

Ono, H., Mishima, A., Ono, S., Fukuda, H. & Vasko, M., 1991, In : Neuropharmacology. 30, 6, p. 585-589 5 p.

Research output: Contribution to journalArticle

Adrenergic Antagonists
Clonidine
Substance P
Spinal Cord
Piperoxan
110 Citations (Scopus)

Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer

Dong, Z. & Zhang, J-T., Sep 2006, In : Critical Reviews in Oncology/Hematology. 59, 3, p. 169-180 12 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
Protein Biosynthesis
Growth
Neoplasms
Carcinogenesis
23 Citations (Scopus)

Inoculated mouse model of Pneumocystis carinii infection

Bartlett, M. S., Queener, S., Durkin, M. M., Shaw, M. A. & Smith, J. W., 1992, In : Diagnostic Microbiology and Infectious Disease. 15, 2, p. 129-134 6 p.

Research output: Contribution to journalArticle

Pneumocystis Infections
Pneumocystis
Pneumocystis carinii
Sulfamethoxazole Drug Combination Trimethoprim
Costs and Cost Analysis
1 Citation (Scopus)

Inoculated mouse model of Pneumocystis carinii pneumonia.

Bartlett, M. S., Queener, S., Durkin, M. M., Shaw, M. M. & Smith, J. W., Nov 1991, In : Journal of Protozoology. 38, 6

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Pneumocystis Infections
Pneumocystis carinii
Sulfamethoxazole Drug Combination Trimethoprim
Animal Models
60 Citations (Scopus)

In Silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation

Wang, Y., Brittain, J. M., Jarecki, B. W., Park, K. D., Wilson, S. M., Wang, B., Hale, R., Meroueh, S., Cummins, T. & Khanna, R., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25296-25307 12 p.

Research output: Contribution to journalArticle

Sodium Channels
Computer Simulation
Binding Sites
Voltage-Gated Sodium Channels
Alanine
33 Citations (Scopus)

Integration of pharmacology into a problem-based learning curriculum for medical students

Sivam, S., Iatridis, P. G. & Vaughn, S., 1995, In : Medical Education. 29, 4, p. 289-296 8 p.

Research output: Contribution to journalArticle

pharmacology
Problem-Based Learning
Medical Students
medical student
Pharmacology
11 Citations (Scopus)

Interaction between DNA polymerase λ and anticancer nucleoside analogs

Garcia-Diaz, M., Murray, M. S., Kunkel, T. A. & Chou, K. M., May 28 2010, In : Journal of Biological Chemistry. 285, 22, p. 16874-16879 6 p.

Research output: Contribution to journalArticle

Cytarabine
DNA-Directed DNA Polymerase
Nucleosides
gemcitabine
Conformations

Interactions between the clinical laboratory and clinical pharmacologists to optimize drug therapy

Vasko, M., 1990, In : Laboratory Medicine. 21, 7, p. 415-422 8 p.

Research output: Contribution to journalArticle

Clinical laboratories
Drug therapy

Interactions of peripheral endothelin-1 and nerve growth factor as contributors to persistent Cutaneous Pain

Khodorova, A., Zhang, Y., Nicol, G. & Strichartz, G., Jan 1 2018, In : Physiological Research. 67, p. S215-S225

Research output: Contribution to journalArticle

Endothelin-1
Nerve Growth Factor
Pain
Skin
Touch
7 Citations (Scopus)

Interleukin-driven insulin-like growth factor promotes prostatic inflammatory hyperplasia

Hahn, A. M., Myers, J. D., McFarland, E. K., Lee, S. & Jerde, T., Dec 1 2014, In : Journal of Pharmacology and Experimental Therapeutics. 351, 3, p. 606-615 10 p.

Research output: Contribution to journalArticle

Interleukins
Prostatic Hyperplasia
Somatomedins
Inflammation
Prostatic Neoplasms
58 Citations (Scopus)
Sphingosine
Nerve Growth Factor
Sensory Receptor Cells
Ceramides
Action Potentials
6 Citations (Scopus)

Intraganglionic signaling as a novel nasal-meningeal pathway for TRPA1-dependent trigeminovascular activation by inhaled environmental irritants

Kunkler, P. E., Ballard, C. J., Pellman, J. J., Zhang, L., Oxford, G. S. & Hurley, J., Jul 31 2014, In : PLoS One. 9, 7, e103086.

Research output: Contribution to journalArticle

Irritants
Nose
Intranasal Administration
Trigeminal Ganglion
Neurons
72 Citations (Scopus)

Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices

Southall, M. D., Michael, R. L. & Vasko, M., Oct 1998, In : Pain. 78, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

Neuropeptides
Spinal Cord
Anti-Inflammatory Agents
Inflammation
Pharmaceutical Preparations
89 Citations (Scopus)

Intrinsic disorder in pathogenic and non-pathogenic microbes: Discovering and analyzing the unfoldomes of early-branching eukaryotes

Mohan, A., Sullivan, W., Radivojac, P., Dunker, A. & Uversky, V. N., 2008, In : Molecular BioSystems. 4, 4, p. 328-340 13 p.

Research output: Contribution to journalArticle

Eukaryota
Proteome
Proteins
Genes
Intrinsically Disordered Proteins
32 Citations (Scopus)

In vitro activities of acridone alkaloids against Pneumocystis carinii

Queener, S., Fujioka, H., Nishiyama, Y., Furukawa, H., Bartlett, M. S. & Smith, J. W., 1991, In : Antimicrobial Agents and Chemotherapy. 35, 2, p. 377-379 3 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Alkaloids
Primaquine
Rutaceae
Chloroquine
4 Citations (Scopus)

In vitro and in vivo models of Pneumocystis carinii

Bartlett, M. S., Queener, S., Shaw, M. M., Durant, P. J., Lee, C-H. & Smith, J. W., Nov 1997, In : Journal of Eukaryotic Microbiology. 44, 6

Research output: Contribution to journalArticle

Pneumocystis
Animal Disease Models
Pneumocystis carinii
Pneumocystis Pneumonia
Antifungal Agents
12 Citations (Scopus)

In vitro release of endogenous dopamine from the striatum of the weaver mutant mouse

Simon, J. R., Yu, H., Richter, J. A., Vasko, M. & Ghetti, B., Nov 1991, In : Journal of Neurochemistry. 57, 5, p. 1478-1482 5 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopamine
Corpus Striatum
Amphetamine
Potassium
17 Citations (Scopus)

Isolation and characterization of CvIV4: A pain inducing α- scorpion toxin

Rowe, A. H., Xiao, Y., Scales, J., Linse, K. D., Rowe, M. P., Cummins, T. & Zakon, H. H., Aug 24 2011, In : PLoS One. 6, 8, e23520.

Research output: Contribution to journalArticle

Scorpions
Scorpiones
Venoms
venoms
pain
8 Citations (Scopus)

Isolation and characterization of rat lung Pneumocystis carinii gp120.

Paulsrud, J. R., Queener, S., Bartlett, M. S. & Smith, J. W., Nov 1991, In : Journal of Protozoology. 38, 6

Research output: Contribution to journalArticle

Pneumocystis carinii
Lung
Peptides
Glycoproteins
Cyanogen Bromide
31 Citations (Scopus)

Isolation and culture of sensory neurons from the dorsal-root ganglia of embryonic or adult rats.

Burkey, T. H., Hingtgen, C. M. & Vasko, M., 2004, In : Methods in molecular medicine. 99, p. 189-202 14 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Sensory Receptor Cells
Physiological Phenomena
Pathologic Processes
Neurons
49 Citations (Scopus)

Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons

Evans, A. R., Junger, H., Southall, M. D., Nicol, G., Sorkin, L. S., Broome, J. T., Bailey, T. W. & Vasko, M., Jun 2000, In : Journal of Pharmacology and Experimental Therapeutics. 293, 3, p. 912-920 9 p.

Research output: Contribution to journalArticle

Isoprostanes
Nociception
Eicosanoids
Sensory Receptor Cells
Dinoprostone
35 Citations (Scopus)

KB-R7943, an inhibitor of the reverse Na +/Ca 2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex i

Brustovetsky, T., Brittain, M. K., Sheets, P., Cummins, T., Pinelis, V. & Broustovetski, N., Jan 2011, In : British Journal of Pharmacology. 162, 1, p. 255-270 16 p.

Research output: Contribution to journalArticle

Sodium-Calcium Exchanger
N-Methyl-D-Aspartate Receptors
Mitochondria
Neurons
NAD
10 Citations (Scopus)
Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Catalytic Domain
Trimethoprim
21 Citations (Scopus)

Knockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory ganglion

Xie, W., Strong, J. A., Kays, J., Nicol, G. & Zhang, J. M., Apr 25 2012, In : Neuroscience Letters. 515, 1, p. 61-65 5 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Sensory Ganglia
Inflammation
Pain
Small Interfering RNA
40 Citations (Scopus)

Lack of manifestations of diazoxide/5-hydroxydecanoate-sensitive KATP channel in rat brain nonsynaptosomal mitochondria

Brustovetsky, T., Shalbuyeva, N. & Broustovetski, N., Oct 1 2005, In : Journal of Physiology. 568, 1, p. 47-59 13 p.

Research output: Contribution to journalArticle

Diazoxide
KATP Channels
Mitochondria
ATP Translocases Mitochondrial ADP
Adenosine Triphosphate
2 Citations (Scopus)
Atovaquone
Toxoplasma
Toxoplasma gondii
Mitochondrial DNA
Plasticity
5 Citations (Scopus)

L-DOPA-induced activation of striatal p38MAPK and CREB in neonatal dopaminergic denervated rat: Relevance to self-injurious behavior

Sivam, S., Pugazhenthi, S., Pugazhenthi, V. & Brown, H., Feb 1 2008, In : Journal of Neuroscience Research. 86, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Self-Injurious Behavior
Dihydroxyphenylalanine
Dopamine
Serotonin
24 Citations (Scopus)

Lidocaine reduces the transition to slow inactivation in Na v1.7 voltage-gated sodium channels

Sheets, P., Jarecki, B. W. & Cummins, T., Sep 2011, In : British Journal of Pharmacology. 164, 2 B, p. 719-730 12 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Lidocaine
Pain
Mutation
Tetrodotoxin
65 Citations (Scopus)

Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+

Cody, V., Galitsky, N., Rak, D., Luft, J. R., Pangborn, W. & Queener, S., Apr 6 1999, In : Biochemistry. 38, 14, p. 4303-4312 10 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
NADP
Folic Acid
Crystal structure
39 Citations (Scopus)

Lipid mediators of sensitivity in sensory neurons

Park, K. A. & Vasko, M., Nov 2005, In : Trends in Pharmacological Sciences. 26, 11, p. 571-577 7 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Neurons
Lipids
Lysophospholipids
Inflammation
55 Citations (Scopus)

Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations

Piper, J. R., Johnson, C. A., Krauth, C. A., Carter, R. L., Hosmer, C. A., Queener, S., Borotz, S. E. & Pfefferkorn, E. R., Mar 15 1996, In : Journal of Medicinal Chemistry. 39, 6, p. 1271-1280 10 p.

Research output: Contribution to journalArticle

Trimetrexate
Folic Acid Antagonists
Pneumocystis carinii
Opportunistic Infections
Toxoplasma
16 Citations (Scopus)

Lithium and haloperidol differentially alter the dynorphin A (1-8) and enkephalin levels in the neurointermediate lobe of rat pituitary

Sivam, S., Smith, D. R., Takeuchi, K. & Hong, J. S., 1987, In : Neuropeptides. 10, 3, p. 291-298 8 p.

Research output: Contribution to journalArticle

dynorphin (1-8)
Enkephalins
Haloperidol
Lithium
Rats
41 Citations (Scopus)

Lithium desensitizes brain mitochondria to calcium, antagonizes permeability transition, and diminishes cytochrome c release

Shalbuyeva, N., Brustovetsky, T. & Broustovetski, N., Jun 22 2007, In : Journal of Biological Chemistry. 282, 25, p. 18057-18068 12 p.

Research output: Contribution to journalArticle

Mitochondria
Cytochromes c
Lithium
Permeability
Brain
35 Citations (Scopus)

Lithium increases dynorphin A(1-8) and prodynorphin mRNA levels in the basal ganglia of rats

Sivam, S., Takeuchi, K., Li, S., Douglass, J., Civelli, O., Calvetta, L., Herbert, E., McGinty, J. F. & Hong, J. S., 1988, In : Molecular Brain Research. 3, 2, p. 155-163 9 p.

Research output: Contribution to journalArticle

dynorphin (1-8)
Basal Ganglia
Lithium
Messenger RNA
Haloperidol
35 Citations (Scopus)

Lithium increases rat striatal beta- and gamma-preprotachykinin messenger RNAs

Sivam, S., Krause, J. E., Takeuchi, K., Li, S., McGinty, J. F. & Hong, J. S., 1989, In : Journal of Pharmacology and Experimental Therapeutics. 248, 3, p. 1297-1301 5 p.

Research output: Contribution to journalArticle

Corpus Striatum
Lithium
Messenger RNA
Substance P
Haloperidol
4 Citations (Scopus)

Local anesthetics: A new hydrophilic pathway for the drug-receptor reaction

Butterworth, J. & Oxford, G. S., Jul 2009, In : Anesthesiology. 111, 1, p. 12-14 3 p.

Research output: Contribution to journalArticle

Drug Receptors
Local Anesthetics
9 Citations (Scopus)

Local Antinociception Induced by Endothelin-1 in the Hairy Skin of the Rat's Back

Shrestha, S., Gracias, N. G., Mujenda, F., Khodorova, A., Vasko, M. & Strichartz, G. R., Jul 2009, In : Journal of Pain. 10, 7, p. 702-714 13 p.

Research output: Contribution to journalArticle

Endothelin-1
Skin
Nimodipine
Subcutaneous Injections
Epinephrine
46 Citations (Scopus)

Long-term diabetes alters the hepatobiliary clearance of acetaminophen, bilirubin and digoxin

Watkins, J. B. & Sherman, S. E., 1992, In : Journal of Pharmacology and Experimental Therapeutics. 260, 3, p. 1337-1343 7 p.

Research output: Contribution to journalArticle

Digoxin
Acetaminophen
Bilirubin
Insulin
Half-Life
3 Citations (Scopus)
Cyclic AMP-Dependent Protein Kinases
Dinoprostone
Eicosanoids
Calcitonin Gene-Related Peptide
Capsaicin