Pharmacology & Toxicology

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2008

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain II voltage sensor in the closed configuration

Xiao, Y., Bingham, J. P., Zhu, W., Moczydlowski, E., Liang, S. & Cummins, T. R., Oct 3 2008, In : Journal of Biological Chemistry. 283, 40, p. 27300-27313 14 p.

Research output: Contribution to journalArticle

115 Scopus citations
28 Scopus citations

The transcription of bradyzoite genes in Toxoplasma gondii is controlled by autonomous promoter elements

Behnke, M. S., Radke, J. B., Smith, A. T., Sullivan, W. J. & White, M. W., Jun 1 2008, In : Molecular Microbiology. 68, 6, p. 1502-1518 17 p.

Research output: Contribution to journalArticle

70 Scopus citations

Third prize: Effect of hydrocortisone on porcine ureteral contractility in vitro

Bandi, G., Wilkinson, E. A., Cary-Coyle, T. L., Jerde, T. J. & Nakada, S. Y., Jun 1 2008, In : Journal of Endourology. 22, 6, p. 1169-1173 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
24 Scopus citations

TRAIL recombinant adenovirus triggers robust apoptosis in multidrug-resistant HL-60/Vinc cells preferentially through death receptor DR5

Wu, C. H., Kao, C. H. & Safa, A. R., Jul 1 2008, In : Human gene therapy. 19, 7, p. 731-743 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii

Narasimhan, J., Joyce, B. R., Naguleswaran, A., Smith, A. T., Livingston, M. R., Dixon, S. E., Coppens, I., Wek, R. C. & Sullivan, W. J., Jun 13 2008, In : Journal of Biological Chemistry. 283, 24, p. 16591-16601 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

Transposon-based mutagenesis identifies short RIP1 as an activator of NFκB

Dasgupta, M., Agarwal, M. K., Varley, P., Lu, T., Stark, G. R. & Kandel, E. S., Jul 15 2008, In : Cell Cycle. 7, 14, p. 2249-2256 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Use of non-mammalian alternative models for neurotoxicological study

Peterson, R. T., Nass, R., Boyd, W. A., Freedman, J. H., Dong, K. & Narahashi, T., May 2008, In : NeuroToxicology. 29, 3, p. 546-555 10 p.

Research output: Contribution to journalArticle

117 Scopus citations
2007

Aberrant constitutive activation of nuclear factor κB in glioblastoma multiforme drives invasive phenotype

Raychaudhuri, B., Han, Y., Lu, T. & Vogelbaum, M. A., Oct 1 2007, In : Journal of Neuro-Oncology. 85, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I

Zhu, W., Xu, P., Cuascut, F. X., Hall, A. K. & Oxford, G. S., Dec 12 2007, In : Journal of Neuroscience. 27, 50, p. 13770-13780 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

A Nav 1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity

Sheets, P. L., Jackson, J. O., Waxman, S. G., Dib-hajj, S. D. & Cummins, T. R., Jun 1 2007, In : Journal of Physiology. 581, 3, p. 1019-1031 13 p.

Research output: Contribution to journalArticle

126 Scopus citations

A novel comonomer-free light-cured glass-ionomer cement for reduced cytotoxicity and enhanced mechanical strength

Xie, D., Yang, Y., Zhao, J., Park, J. G. & Zhang, J. T., Aug 1 2007, In : Dental Materials. 23, 8, p. 994-1003 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

A rapid oxidation and persistent decrease in the vesicular monoamine transporter 2 after methamphetamine

Eyerman, D. J. & Yamamoto, B. K., Nov 1 2007, In : Journal of Neurochemistry. 103, 3, p. 1219-1227 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

A Toxoplasma gondii mutant defective in responding to calcium fluxes shows reduced in vivo pathogenicity

Lavine, M. D., Knoll, L. J., Rooney, P. J. & Arrizabalaga, G., Oct 1 2007, In : Molecular and Biochemical Parasitology. 155, 2, p. 113-122 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

ATP-sensitive potassium currents reduce the PGE2-mediated enhancement of excitability in adult rat sensory neurons

Chi, X. X., Jiang, X. & Nicol, G. D., May 11 2007, In : Brain research. 1145, 1, p. 28-40 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Augmentation of methamphetamine-induced toxicity in the rat striatum by unpredictable stress: Contribution of enhanced hyperthermia

Tata, D. A., Raudensky, J. & Yamamoto, B. K., Aug 1 2007, In : European Journal of Neuroscience. 26, 3, p. 739-748 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

c-Jun promotes cellular survival by suppression of PTEN

Hettinger, K., Vikhanskaya, F., Poh, M. K., Lee, M. K., de Belle, I., Zhang, J. T., Reddy, S. A. G. & Sabapathy, K., Feb 1 2007, In : Cell Death and Differentiation. 14, 2, p. 218-229 12 p.

Research output: Contribution to journalArticle

100 Scopus citations

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

Juang, S. H., Lung, C. C., Hsu, P. C., Hsu, K. S., Li, Y. C., Hong, P. C., Shiah, H. S., Kuo, C. C., Huang, C. W., Wang, Y. C., Huang, L., Chen, T. S., Chen, S. F., Fu, K. C., Hsu, C. L., Lin, M. J., Chang, C. J., Ashendel, C. L., Chan, T. C. K., Chou, K. M. & 1 others, Chang, J. C., Jan 1 2007, In : Molecular cancer therapeutics. 6, 1, p. 193-202 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino- 5-ethylpyrrolo[2,3-d]pyrimidines as antifolates

Gangjee, A., Zeng, Y., Talreja, T., McGuire, J. J., Kisliuk, R. L. & Queener, S. F., Jun 28 2007, In : Journal of Medicinal Chemistry. 50, 13, p. 3046-3053 8 p.

Research output: Contribution to journalArticle

197 Scopus citations
165 Scopus citations

Dose-dependent cross-talk between the transforming growth factor-β and interleukin-1 signaling pathways

Lu, T., Tian, L., Han, Y., Vogelbaum, M. & Stark, G. R., Mar 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4365-4370 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Doxazosin Relaxes Ureteral Smooth Muscle and Inhibits Epinephrine-Induced Ureteral Contractility In Vitro

Nakada, S. Y., Coyle, T. L. C., Ankem, M. K., Moon, T. D. & Jerde, T. J., Oct 1 2007, In : Urology. 70, 4, p. 817-821 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release

Mark, K. A., Quinton, M. S., Russek, S. J. & Yamamoto, B. K., Jun 20 2007, In : Journal of Neuroscience. 27, 25, p. 6823-6831 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function

Raudensky, J. & Yamamoto, B. K., Mar 2 2007, In : Brain research. 1135, 1, p. 129-135 7 p.

Research output: Contribution to journalArticle

50 Scopus citations
7 Scopus citations

Haloperidol treatment after high-dose methamphetamine administration is excitotoxic to GABA cells in the substantia nigra pars reticulata

Hatzipetros, T., Raudensky, J. G., Soghomonian, J. J. & Yamamoto, B. K., May 30 2007, In : Journal of Neuroscience. 27, 22, p. 5895-5902 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Lithium desensitizes brain mitochondria to calcium, antagonizes permeability transition, and diminishes cytochrome c release

Shalbuyeva, N., Brustovetsky, T. & Brustovetsky, N., Jun 22 2007, In : Journal of Biological Chemistry. 282, 25, p. 18057-18068 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Manipulation of the potassium channel Kv1.1 and its effect on neuronal excitability in rat sensory neurons

Xian, X. C. & Nicol, G. D., Nov 1 2007, In : Journal of Neurophysiology. 98, 5, p. 2683-2692 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Melatonin as a principal component of red light therapy

Yeager, R. L., Oleske, D. A., Sanders, R. A., Watkins, J. B., Eells, J. T. & Henshel, D. S., Jun 1 2007, In : Medical Hypotheses. 69, 2, p. 372-376 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mitochondria-mediated and p53-associated apoptosis induced in human cancer cells by a novel selenophene derivative, D-501036

Shiah, H. S., Lee, W. S., Juang, S. H., Hong, P. C., Lung, C. C., Chang, C. J., Chou, K. M. & Chang, J. Y., Mar 1 2007, In : Biochemical Pharmacology. 73, 5, p. 610-619 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Molecular interactions of the gating modifier toxin ProTx-II with Na v1.5: Implied existence of a novel toxin binding site coupled to activation

Smith, J. J., Cummins, T. R., Alphy, S. & Blumenthal, K. M., Apr 27 2007, In : Journal of Biological Chemistry. 282, 17, p. 12687-12697 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Neurotoxic effects of chronic restraint stress in the striatum of methamphetamine-exposed rats

Quinton, M. S. & Yamamoto, B. K., Aug 1 2007, In : Psychopharmacology. 193, 3, p. 341-350 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Neurotoxic potential of depleted uranium - Effects in primary cortical neuron cultures and in Caenorhabditis elegans

Jiang, G. C. T., Tidwell, K., Mclaughlin, B. A., Cai, J., Gupta, R. C., Milatovic, D., Nass, R. & Aschner, M., Oct 1 2007, In : Toxicological Sciences. 99, 2, p. 553-565 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Novel boron-containing, nonclassical antifolates: Synthesis and preliminary biological and structural evaluation

Reynolds, R. C., Campbell, S. R., Fairchild, R. G., Kisliuk, R. L., Micca, P. L., Queener, S. F., Riordan, J. M., Sedwick, W. D., Waud, W. R., Leung, A. K. W., Dixon, R. W., Suling, W. J. & Borhani, D. W., Jul 12 2007, In : Journal of Medicinal Chemistry. 50, 14, p. 3283-3289 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Oligomerization domain of the multidrug resistance-associated transporter ABCG2 and its dominant inhibitory activity

Xu, J., Peng, H., Chen, Q., Liu, Y., Dong, Z. & Zhang, J. T., May 1 2007, In : Cancer Research. 67, 9, p. 4373-4381 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1

Zhu, W. & Oxford, G. S., Apr 1 2007, In : Molecular and Cellular Neuroscience. 34, 4, p. 689-700 12 p.

Research output: Contribution to journalArticle

114 Scopus citations
11 Scopus citations

Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT1B receptor

Amato, J. L., Bankson, M. G. & Yamamoto, B. K., Mar 7 2007, In : Neuropsychopharmacology. 32, 4, p. 946-954 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii

Smith, A. T., Livingston, M. R., Mai, A., Filetici, P., Queener, S. F. & Sullivan, W. J., Mar 1 2007, In : Antimicrobial Agents and Chemotherapy. 51, 3, p. 1109-1111 3 p.

Research output: Contribution to journalArticle

27 Scopus citations

Regulation of function by dimerization through the amino-terminal membrane-spanning domain of human ABCC1/MRP1

Yang, Y., Liu, Y., Dong, Z., Xu, J., Peng, H., Liu, Z. & Zhang, J. T., Mar 23 2007, In : Journal of Biological Chemistry. 282, 12, p. 8821-8830 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development

Liu, Z., Dong, Z., Yang, Z., Chen, Q., Pan, Y., Yang, Y., Cui, P., Zhang, X. & Zhang, J. T., Sep 2007, In : Differentiation. 75, 7, p. 652-661 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
25 Scopus citations

Suppression of endogenous antioxidant enzymes by 2,3,7,8- tetrachlorodibenzo-p-dioxin-induced oxidative stress in chicken liver during development

Lim, J., DeWitt, J. C., Sanders, R. A., Watkins, J. B. & Henshel, D. S., May 1 2007, In : Archives of Environmental Contamination and Toxicology. 52, 4, p. 590-595 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
34 Scopus citations

Toxoplasma gondii: Induction of egress by the potassium ionophore nigericin

Fruth, I. A. & Arrizabalaga, G., Dec 1 2007, In : International Journal for Parasitology. 37, 14, p. 1559-1567 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
2006

670 Nanometer light treatment attenuates dioxin toxicity in the developing chick embryo

Yeager, R. L., Lim, J., Millsap, D. S., Jasevicius, A. V., Sanders, R. A., Whelan, H. T., Watkins, J. B., Eells, J. T. & Henshel, D. S., Dec 1 2006, In : Journal of Biochemical and Molecular Toxicology. 20, 6, p. 271-278 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

A novel role of DNA polymerase η in modulating cellular sensitivity to chemotherapeutic agents

Chen, Y. W., Cleaver, J. E., Hanaoka, F., Chang, C. F. & Chou, K. M., Apr 1 2006, In : Molecular Cancer Research. 4, 4, p. 257-265 9 p.

Research output: Contribution to journalArticle

95 Scopus citations

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

Rush, A. M., Dib-Hajj, S. D., Liu, S., Cummins, T. R., Black, J. A. & Waxman, S. G., May 23 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 21, p. 8245-8250 6 p.

Research output: Contribution to journalArticle

287 Scopus citations

Calcium-dependent spontaneously reversible remodeling of brain mitochondria

Shalbuyeva, N., Brustovetsky, T., Bolshakov, A. & Brustovetsky, N., Dec 8 2006, In : Journal of Biological Chemistry. 281, 49, p. 37547-37558 12 p.

Research output: Contribution to journalArticle

53 Scopus citations