Pharmacology & Toxicology

Publications 1971 2020

Filter
Article
2007
50 Citations (Scopus)

Oligomerization domain of the multidrug resistance-associated transporter ABCG2 and its dominant inhibitory activity

Xu, J., Peng, H., Chen, Q., Liu, Y., Dong, Z. & Zhang, J-T., May 1 2007, In : Cancer Research. 67, 9, p. 4373-4381 9 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Drug Resistance
ATP-Binding Cassette Transporters
HEK293 Cells
Neoplasms
9 Citations (Scopus)

Painful research: Identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels

Rush, A. M. & Cummins, T., Aug 2007, In : Molecular Interventions. 7, 4, p. 192-195 4 p.

Research output: Contribution to journalArticle

Aniline Compounds
Sodium Channel Blockers
Furans
Sodium Channels
Neurons
114 Citations (Scopus)

Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1

Zhu, W. & Oxford, G. S., Apr 2007, In : Molecular and Cellular Neuroscience. 34, 4, p. 689-700 12 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Nerve Growth Factor
Mitogen-Activated Protein Kinases
Diagnosis-Related Groups
Capsaicin
11 Citations (Scopus)
DNA-Activated Protein Kinase
RNA Helicases
Phosphorylation
Multiple Drug Resistance
P-Glycoprotein
26 Citations (Scopus)

Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii

Smith, A. T., Livingston, M. R., Mai, A., Filetici, P., Queener, S. & Sullivan, W., Mar 2007, In : Antimicrobial Agents and Chemotherapy. 51, 3, p. 1109-1111 3 p.

Research output: Contribution to journalArticle

Histone Acetyltransferases
Toxoplasma
Apicoplasts
Plastids
Organelles
38 Citations (Scopus)

Regulation of function by dimerization through the amino-terminal membrane-spanning domain of human ABCC1/MRP1

Yang, Y., Liu, Y., Dong, Z., Xu, J., Peng, H., Liu, Z. & Zhang, J-T., Mar 23 2007, In : Journal of Biological Chemistry. 282, 12, p. 8821-8830 10 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Dimerization
Membranes
Chemotherapy
Nucleotides
15 Citations (Scopus)

Role of calcium in volume-activated chloride currents in a mouse cholangiocyte cell line

Chen, B., Nicol, G. & Cho, W. K., Jan 2007, In : Journal of Membrane Biology. 215, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Chlorides
Calcium
Cell Line
Bile Ducts
Chloride Channels
34 Citations (Scopus)

Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development

Liu, Z., Dong, Z., Yang, Z., Chen, Q., Pan, Y., Yang, Y., Cui, P., Zhang, X. & Zhang, J-T., Sep 2007, In : Differentiation. 75, 7, p. 652-661 10 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
Cell Differentiation
Epithelial Cells
Protein Biosynthesis
RNA Interference
24 Citations (Scopus)
Ion Channel Gating
Sodium Channel Blockers
Protein Conformation
Muscle Proteins
Sodium Channels
14 Citations (Scopus)

Suppression of endogenous antioxidant enzymes by 2,3,7,8- tetrachlorodibenzo-p-dioxin-induced oxidative stress in chicken liver during development

Lim, J., DeWitt, J. C., Sanders, R. A., Watkins, J. B. & Henshel, D. S., May 2007, In : Archives of Environmental Contamination and Toxicology. 52, 4, p. 590-595 6 p.

Research output: Contribution to journalArticle

Oxidative stress
Antioxidants
Liver
dioxin
antioxidant
323 Citations (Scopus)

The roles of sodium channels in nociception: Implications for mechanisms of pain

Cummins, T., Sheets, P. & Waxman, S. G., Oct 2007, In : Pain. 131, 3, p. 243-257 15 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Nociception
Sodium Channels
Pain
Sensory Receptor Cells
112 Citations (Scopus)
Nociceptors
Nerve Growth Factor
Sensory Receptor Cells
Neurons
Nerve Growth Factor Receptors
32 Citations (Scopus)
ATP-Binding Cassette Transporters
Drug Resistance
Drug Therapy
Multiple Drug Resistance
Neoplasms
42 Citations (Scopus)

Use of comparative proteomics to identify potential resistance mechanisms in cancer treatment

Zhang, J-T. & Liu, Y., Dec 2007, In : Cancer Treatment Reviews. 33, 8, p. 741-756 16 p.

Research output: Contribution to journalArticle

Proteomics
Drug Resistance
Neoplasms
Cell Line
Therapeutics
42 Citations (Scopus)

Voltage-gated sodium channel blockers for the treatment of neuropathic pain

Cummins, T. & Rush, A. M., Nov 2007, In : Expert Review of Neurotherapeutics. 7, 11, p. 1597-1612 16 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channel Blockers
Neuralgia
Sodium Channel Blockers
Sodium Channels
Pain
2006
14 Citations (Scopus)

670 Nanometer light treatment attenuates dioxin toxicity in the developing chick embryo

Yeager, R. L., Lim, J., Millsap, D. S., Jasevicius, A. V., Sanders, R. A., Whelan, H. T., Watkins, J. B., Eells, J. T. & Henshel, D. S., 2006, In : Journal of Biochemical and Molecular Toxicology. 20, 6, p. 271-278 8 p.

Research output: Contribution to journalArticle

Dioxins
Chick Embryo
Toxicity
Light
Light emitting diodes
282 Citations (Scopus)

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

Rush, A. M., Dib-Hajj, S. D., Liu, S., Cummins, T., Black, J. A. & Waxman, S. G., May 23 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 21, p. 8245-8250 6 p.

Research output: Contribution to journalArticle

Sodium Channels
Neurons
Mutation
Erythromelalgia
Ion Channels
53 Citations (Scopus)

Calcium-dependent spontaneously reversible remodeling of brain mitochondria

Shalbuyeva, N., Brustovetsky, T., Bolshakov, A. & Broustovetski, N., Dec 8 2006, In : Journal of Biological Chemistry. 281, 49, p. 37547-37558 12 p.

Research output: Contribution to journalArticle

Mitochondria
Swelling
Brain
Potassium-Hydrogen Antiporters
Calcium
48 Citations (Scopus)

Cellular FLICE-like inhibitory protein (c-FLIP): A novel target for Taxol-induced apoptosis

Day, T. W., Najafi, F., Wu, C. H. & Safa, A., May 28 2006, In : Biochemical Pharmacology. 71, 11, p. 1551-1561 11 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Staphylococcal Protein A
Paclitaxel
Protein S
Apoptosis
15 Citations (Scopus)

Effects of low-carbohydrate diet and Pycnogenol® treatment on retinal antioxidant enzymes in normal and diabetic rats

Kamuren, Z. T., McPeek, C. G., Sanders, R. A. & Watkins, J. B., Feb 2006, In : Journal of Ocular Pharmacology and Therapeutics. 22, 1, p. 10-18 9 p.

Research output: Contribution to journalArticle

Carbohydrate-Restricted Diet
Pinus
Antioxidants
Cataract
Enzymes
45 Citations (Scopus)

Histone mediated gene activation in Toxoplasma gondii

Sullivan, W. & Hakimi, M. A., Aug 2006, In : Molecular and Biochemical Parasitology. 148, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

Toxoplasma
Histones
Transcriptional Activation
Parasites
Histone Code
60 Citations (Scopus)

Histones and histone modifications in protozoan parasites

Sullivan, W., Naguleswaran, A. & Angel, S. O., Dec 2006, In : Cellular Microbiology. 8, 12, p. 1850-1861 12 p.

Research output: Contribution to journalArticle

Histone Code
Histones
Parasites
Eukaryota
Chromatin
87 Citations (Scopus)

Identification of 14-3-3σ as a contributor to drug resistance in human breast cancer cells using functional proteomic analysis

Liu, Y., Liu, H., Han, B. & Zhang, J-T., Mar 15 2006, In : Cancer Research. 66, 6, p. 3248-3255 8 p.

Research output: Contribution to journalArticle

MCF-7 Cells
Drug Resistance
Proteomics
Breast Neoplasms
Multiple Drug Resistance
13 Citations (Scopus)

Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor

Sheets, P., Gerner, P., Wang, C. F., Wang, S. Y., Ging, K. W. & Cummins, T., Oct 2006, In : Journal of Neurophysiology. 96, 4, p. 1848-1859 12 p.

Research output: Contribution to journalArticle

Trifluoperazine
Sodium Channels
Local Anesthetics
Calmodulin
Inhibition (Psychology)
109 Citations (Scopus)

Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer

Dong, Z. & Zhang, J-T., Sep 2006, In : Critical Reviews in Oncology/Hematology. 59, 3, p. 169-180 12 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
Protein Biosynthesis
Growth
Neoplasms
Carcinogenesis
58 Citations (Scopus)
Sphingosine
Nerve Growth Factor
Sensory Receptor Cells
Ceramides
Action Potentials
6 Citations (Scopus)

Low-carbohydrate diet and oxidative stress in diabetic and nondiabetic rats

Kamuren, Z. T., Sanders, R. & Watkins, J. B., 2006, In : Journal of Biochemical and Molecular Toxicology. 20, 5, p. 259-269 11 p.

Research output: Contribution to journalArticle

Carbohydrate-Restricted Diet
Oxidative stress
Nutrition
Rats
Glutathione Peroxidase
9 Citations (Scopus)

Mutations in the sodium channel Nav1.7 underlie inherited erythromelalgia

Dib-Hajj, S. D., Rush, A. M., Cummins, T. & Waxman, S. G., 2006, In : Drug Discovery Today: Disease Mechanisms. 3, 3, p. 343-350 8 p.

Research output: Contribution to journalArticle

Erythromelalgia
Sodium Channels
Mutation
Neurons
Sympathetic Ganglia
14 Citations (Scopus)
Folic Acid Antagonists
Pyrimidines
Carbon
Pneumocystis carinii
Mycobacterium avium
37 Citations (Scopus)

Pair of unusual GCN5 histone acetyltransferases and ADA2 homologues in the protozoan parasite Toxoplasma gondii

Bhatti, M. M., Livingston, M., Mullapudi, N. & Sullivan, W., Jan 2006, In : Eukaryotic Cell. 5, 1, p. 62-76 15 p.

Research output: Contribution to journalArticle

Toxoplasma
Toxoplasma gondii
Protozoa
Parasites
Eukaryota
26 Citations (Scopus)

P-glycoprotein enhances TRAIL-triggered apoptosis in multidrug resistant cancer cells by interacting with the death receptor DR5

Park, S. J., Wu, C. H., Choi, M. R., Najafi, F., Emami, A. & Safa, A., Jul 28 2006, In : Biochemical Pharmacology. 72, 3, p. 293-307 15 p.

Research output: Contribution to journalArticle

Death Domain Receptors
P-Glycoprotein
Cells
Apoptosis
Neoplasms
6 Citations (Scopus)
Corpus Striatum
Enkephalins
Oxidopamine
Dopamine Agonists
Substance P
30 Citations (Scopus)

Sensitizing hormone-refractory prostate cancer cells to drug treatment by targeting 14-3-3σ

Han, B., Xie, H., Chen, Q. & Zhang, J-T., Apr 2006, In : Molecular Cancer Therapeutics. 5, 4, p. 903-912 10 p.

Research output: Contribution to journalArticle

Drug Delivery Systems
Prostatic Neoplasms
Androgens
Hormones
Drug Resistance
60 Citations (Scopus)
Sensory Receptor Cells
G-Protein-Coupled Receptors
Architectural Accessibility
GTP-Binding Proteins
Action Potentials
3 Citations (Scopus)

Synthesis of 2,6-diamino-5-[(2-substituted phenylamino)ethyl]pyrimidin- 4(3H)-one as inhibitors of folate metabolizing enzymes

Gangjee, A., Wang, Y., Queener, S. & Kisliuk, R. L., Nov 2006, In : Journal of Heterocyclic Chemistry. 43, 6, p. 1523-1531 9 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Folic Acid
Escherichia coli
Aniline Compounds
Enzymes
19 Citations (Scopus)

The amino terminus of the human multidrug resistance transporter ABCC1 has a U-shaped folding with a gating function

Chen, Q., Yang, Y., Li, L. & Zhang, J-T., Oct 13 2006, In : Journal of Biological Chemistry. 281, 41, p. 31152-31163 12 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Multiple Drug Resistance
Cells
Chemotherapy
Extracellular Space
256 Citations (Scopus)

The Role of Sodium Channels in Chronic Inflammatory and Neuropathic Pain

Amir, R., Argoff, C. E., Bennett, G. J., Cummins, T., Durieux, M. E., Gerner, P., Gold, M. S., Porreca, F. & Strichartz, G. R., May 2006, In : Journal of Pain. 7, 5 SUPPL.

Research output: Contribution to journalArticle

Sodium Channels
Voltage-Gated Sodium Channels
Neuralgia
Chronic Pain
Sodium Channel Blockers
2005
47 Citations (Scopus)

Activation of calcium-independent phospholipase a2 (iPLA 2) in brain mitochondria and release of apoptogenic factors by BAX and truncated BID

Brustovetsky, T., Antonsson, B., Jemmerson, R., Dubinsky, J. M. & Broustovetski, N., Aug 2005, In : Journal of Neurochemistry. 94, 4, p. 980-994 15 p.

Research output: Contribution to journalArticle

Calcium-Independent Phospholipase A2
Mitochondria
Cytochromes c
Phospholipases A2
Brain
79 Citations (Scopus)

Age-dependent changes in the calcium sensitivity of striatal mitochondria in mouse models of Huntington's disease

Broustovetski, N., LaFrance, R., Purl, K. J., Brustovetsky, T., Keene, C. D., Low, W. C. & Dubinsky, J. M., Jun 2005, In : Journal of Neurochemistry. 93, 6, p. 1361-1370 10 p.

Research output: Contribution to journalArticle

Corpus Striatum
Mitochondria
Huntington Disease
Calcium
Permeability
34 Citations (Scopus)

Age-related changes in regional brain mitochondria from Fischer 344 rats

LaFrance, R., Broustovetski, N., Sherburne, C., DeLong, D. & Dubinsky, J. M., Jun 2005, In : Aging Cell. 4, 3, p. 139-145 7 p.

Research output: Contribution to journalArticle

Inbred F344 Rats
Corpus Striatum
Mitochondria
Brain
Calcium
43 Citations (Scopus)

Cytochrome c release from CNS mitochondria and potential for clinical intervention in apoptosis-mediated CNS diseases

Jemmerson, R., Dubinsky, J. M. & Broustovetski, N., Sep 2005, In : Antioxidants and Redox Signaling. 7, 9-10, p. 1158-1172 15 p.

Research output: Contribution to journalArticle

Mitochondria
Central Nervous System Diseases
Cytochromes c
Apoptosis
Permeability
44 Citations (Scopus)

D2 dopamine receptor activation of potassium channels is selectively decoupled by Gαi-specific GoLoco motif peptides

Webb, C. K., McCudden, C. R., Willard, F. S., Kimple, R. J., Siderovski, D. P. & Oxford, G. S., Mar 2005, In : Journal of Neurochemistry. 92, 6, p. 1408-1418 11 p.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Potassium Channels
Chemical activation
Peptides
GTP-Binding Proteins
50 Citations (Scopus)
Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Substitution reactions
Pneumocystis carinii
Mycobacterium avium
8 Citations (Scopus)
Folic Acid Antagonists
Pyrimidines
Tetrahydrofolate Dehydrogenase
Rats
Addition reactions
32 Citations (Scopus)

Effects of antioxidant treatment on normal and diabetic rat retinal enzyme activities

Dene, B. A., Maritim, A. C., Sanders, R. A. & Watkins, J. B., Feb 2005, In : Journal of Ocular Pharmacology and Therapeutics. 21, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

Antioxidants
Carotenoids
Enzymes
Transferases
Retina
47 Citations (Scopus)

Expression profiling of ABC transporters in a drug-resistant breast cancer cell line using AmpArray

Liu, Y., Peng, H. & Zhang, J-T., Aug 2005, In : Molecular Pharmacology. 68, 2, p. 430-438 9 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
MCF-7 Cells
Multiple Drug Resistance
Breast Neoplasms
Cell Line
15 Citations (Scopus)

Externalization and recognition by macrophages of large subunit of eukaryotic translation initiation factor 3 in apoptotic cells

Nakai, Y., Shiratsuchi, A., Manaka, J., Nakayama, H., Takio, K., Zhang, J-T., Suganuma, T. & Nakanishi, Y., Sep 10 2005, In : Experimental Cell Research. 309, 1, p. 137-148 12 p.

Research output: Contribution to journalArticle

Prokaryotic Initiation Factor-3
Eukaryotic Initiation Factor-3
Eukaryotic Initiation Factors
Macrophages
Cytophagocytosis
305 Citations (Scopus)

Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons

Dib-Hajj, S. D., Rush, A. M., Cummins, T., Hisama, F. M., Novella, S., Tyrrell, L., Marshall, L. & Waxman, S. G., Aug 2005, In : Brain. 128, 8, p. 1847-1854 8 p.

Research output: Contribution to journalArticle

Erythromelalgia
Sensory Receptor Cells
Mutation
Neurons
Pain
31 Citations (Scopus)

Histone acetylase GCN5 enters the nucleus via importin-α in protozoan parasite Toxoplasma gondii

Bhatti, M. M. & Sullivan, W., Feb 18 2005, In : Journal of Biological Chemistry. 280, 7, p. 5902-5908 7 p.

Research output: Contribution to journalArticle

Karyopherins
Histone Acetyltransferases
Toxoplasma
Nuclear Localization Signals
Parasites
122 Citations (Scopus)

Histone-modifying complexes regulate gene expression pertinent to the differentiation of the protozoan parasite Toxoplasma gondii

Saksouk, N., Bhatti, M. M., Kieffer, S., Smith, A. T., Musset, K., Garin, J., Sullivan, W., Cesbron-Delauw, M. F. & Hakimi, M. A., Dec 2005, In : Molecular and Cellular Biology. 25, 23, p. 10301-10314 14 p.

Research output: Contribution to journalArticle

Toxoplasma
Histones
Parasites
Gene Expression
Histone Deacetylases