Pharmacology & Toxicology

Publications 1971 2020

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2005
9 Citations (Scopus)

Identification of proteins interacting with Toxoplasma SRCAP by yeast two-hybrid screening

Nallani, K. C. & Sullivan, W., Mar 2005, In : Parasitology Research. 95, 4, p. 236-242 7 p.

Research output: Contribution to journalArticle

two hybrid system techniques
Toxoplasma
Toxoplasma gondii
Yeasts
yeasts
27 Citations (Scopus)

IMP dehydrogenase from the protozoan parasite Toxoplasma gondii

Sullivan, W., Dixon, S. E., Li, C., Striepen, B. & Queener, S., Jun 2005, In : Antimicrobial Agents and Chemotherapy. 49, 6, p. 2172-2179 8 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Toxoplasma
Parasites
Mycophenolic Acid
Inosine Monophosphate
40 Citations (Scopus)

Lack of manifestations of diazoxide/5-hydroxydecanoate-sensitive KATP channel in rat brain nonsynaptosomal mitochondria

Brustovetsky, T., Shalbuyeva, N. & Broustovetski, N., Oct 1 2005, In : Journal of Physiology. 568, 1, p. 47-59 13 p.

Research output: Contribution to journalArticle

Diazoxide
KATP Channels
Mitochondria
ATP Translocases Mitochondrial ADP
Adenosine Triphosphate
39 Citations (Scopus)

Lipid mediators of sensitivity in sensory neurons

Park, K. A. & Vasko, M., Nov 2005, In : Trends in Pharmacological Sciences. 26, 11, p. 571-577 7 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Neurons
Lipids
Lysophospholipids
Inflammation
40 Citations (Scopus)

Modulation of differentiation-related gene 1 expression by cell cycle blocker mimosine, revealed by proteomic analysis

Dong, Z., Arnold, R. J., Yang, Y., Park, M. H., Hrncirova, P., Mechref, Y., Novotny, M. V. & Zhang, J-T., Jul 2005, In : Molecular & cellular proteomics : MCP. 4, 7, p. 993-1001 9 p.

Research output: Contribution to journalArticle

Mimosine
Proteomics
Cell Cycle
Genes
Cells
35 Citations (Scopus)

MYST family histone acetyltransferases in the protozoan parasite Toxoplasma gondii

Smith, A. T., Tucker-Samaras, S. D., Fairlamb, A. H. & Sullivan, W., Dec 2005, In : Eukaryotic Cell. 4, 12, p. 2057-2065 9 p.

Research output: Contribution to journalArticle

Histone Acetyltransferases
Toxoplasma
Toxoplasma gondii
histones
Histones
87 Citations (Scopus)

Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons

Cummins, T., Dib-Hajj, S. D., Herzog, R. I. & Waxman, S. G., Apr 11 2005, In : FEBS Letters. 579, 10, p. 2166-2170 5 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Sensory Receptor Cells
Neurons
Sodium
NAV1.6 Voltage-Gated Sodium Channel
61 Citations (Scopus)

Pharmacological properties of neuronal TTX-resistant sodium channels and the role of a critical serine pore residue

Leffler, A., Herzog, R. I., Dib-Hajj, S. D., Waxman, S. G. & Cummins, T., Dec 2005, In : Pflugers Archiv European Journal of Physiology. 451, 3, p. 454-463 10 p.

Research output: Contribution to journalArticle

Sodium Channels
Saxitoxin
Tetrodotoxin
Serine
Cadmium
5 Citations (Scopus)
Pneumocystis
Sf9 Cells
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Escherichia coli
37 Citations (Scopus)

Regulation of expression by promoters versus internal ribosome entry site in the 5′-untranslated sequence of the human cyclin-dependent kinase inhibitor p27kip1

Liu, Z., Dong, Z., Han, B., Yang, Y., Liu, Y. & Zhang, J-T., 2005, In : Nucleic Acids Research. 33, 12, p. 3763-3771 9 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
5' Untranslated Regions
DNA
RNA
RNA-Binding Proteins
17 Citations (Scopus)

Regulation of ribonucleotide reductase M2 expression by the upstream AUGs

Dong, Z., Liu, Y. & Zhang, J-T., 2005, In : Nucleic Acids Research. 33, 8, p. 2715-2725 11 p.

Research output: Contribution to journalArticle

5' Untranslated Regions
Initiator Codon
Messenger RNA
Cell Proliferation
Deoxyribonucleotides
26 Citations (Scopus)

Sensory neurons from Nf1 haploinsufficient mice exhibit increased excitability

Wang, Y., Nicol, G., Clapp, D. & Hingtgen, C. M., Dec 2005, In : Journal of Neurophysiology. 94, 6, p. 3670-3676 7 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Sensory Receptor Cells
Neurofibromin 1
Neurofibromatosis 1 Genes
Neurons
6 Citations (Scopus)

Synthesis of three carbon atom bridged 2,4-diaminopyrrolo[2,3-d]- pyrimidines as nonclassical dihydrofolate reductase inhibitors

Gangjee, A., Ye, Z. & Queener, S., Sep 2005, In : Journal of Heterocyclic Chemistry. 42, 6, p. 1127-1133 7 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pyrimidines
Tetrahydrofolate Dehydrogenase
Carbon
Atoms
106 Citations (Scopus)

The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress

Vasko, M., Guo, C. & Kelley, M., Mar 2 2005, In : DNA Repair. 4, 3, p. 367-379 13 p.

Research output: Contribution to journalArticle

Multifunctional Enzymes
DNA Repair Enzymes
Oxidative stress
Small Interfering RNA
Neurons
15 Citations (Scopus)

The protozoan parasite Cryptosporidium parvum possesses two functionally and evolutionarily divergent replication protein A large subunits

Rider, S. D., Cai, X., Sullivan, W., Smith, A. T., Radke, J., White, M. & Zhu, G., Sep 9 2005, In : Journal of Biological Chemistry. 280, 36, p. 31460-31469 10 p.

Research output: Contribution to journalArticle

Replication Protein A
Cryptosporidium parvum
Parasites
Single-Stranded DNA
Protozoan Proteins
53 Citations (Scopus)
Receptors, Prostaglandin E, EP2 Subtype
Spinal Ganglia
Prostaglandin-Endoperoxide Synthases
Interleukin-1
Tumor Necrosis Factor-alpha
2004
55 Citations (Scopus)

A developmental switch in acute sensitization of small dorsal root ganglion (DRG) neurons to capsaicin or noxious heating by NGF

Zhu, W., Galoyan, S. M., Petruska, J. C., Oxford, G. S. & Mendell, L. M., Nov 2004, In : Journal of Neurophysiology. 92, 5, p. 3148-3152 5 p.

Research output: Contribution to journalArticle

Capsaicin
Spinal Ganglia
Nerve Growth Factor
Heating
Neurons
21 Citations (Scopus)
Caspase 6
Caspase 7
P-Glycoprotein
Doxorubicin
Breast Neoplasms
307 Citations (Scopus)

Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain

Black, J. A., Liu, S., Tanaka, M., Cummins, T. & Waxman, S. G., Apr 2004, In : Pain. 108, 3, p. 237-247 11 p.

Research output: Contribution to journalArticle

Sodium Channels
Tetrodotoxin
Spinal Ganglia
Neurons
Pain
218 Citations (Scopus)

Characterization of Oligomeric Human Half-ABC Transporter ATP-binding Cassette G2

Xu, J., Liu, Y., Yang, Y., Bates, S. & Zhang, J-T., May 7 2004, In : Journal of Biological Chemistry. 279, 19, p. 19781-19789 9 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Adenosine Triphosphate
Proteins
Nucleotides
Gels
36 Citations (Scopus)
Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Toxoplasma
Mycobacterium avium
Pyrimidines
20 Citations (Scopus)

Design, synthesis, and computational affinity prediction of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii

Graffner-Nordberg, M., Kolmodin, K., Åqvist, J., Queener, S. & Hallberg, A., May 2004, In : European Journal of Pharmaceutical Sciences. 22, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Esters
Inhalation Administration
9 Citations (Scopus)
Chlorides
Cell Line
Bile Ducts
Baths
Glutamic Acid
266 Citations (Scopus)

Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy

Cummins, T., Dib-Hajj, S. D. & Waxman, S. G., Sep 22 2004, In : Journal of Neuroscience. 24, 38, p. 8232-8236 5 p.

Research output: Contribution to journalArticle

Erythromelalgia
Sodium Channels
Spinal Ganglia
Mutation
Neurons
9 Citations (Scopus)

ET - Phone the pain clinic

Nicol, G., Apr 2004, In : Trends in Neurosciences. 27, 4, p. 177-180 4 p.

Research output: Contribution to journalArticle

Pain Clinics
Endothelin-1
Keratinocytes
Pain
Vasoconstrictor Agents
4 Citations (Scopus)

Evaluating metabolic syndrome in a medical physiology laboratory

Martin, B., Watkins, J. B. & Ramsey, J. W., Dec 2004, In : American Journal of Physiology - Advances in Physiology Education. 28, 4, p. 195-198 4 p.

Research output: Contribution to journalArticle

Cholesterol
Meals
Triglycerides
Diet
Dietary Carbohydrates
76 Citations (Scopus)
Multiple Drug Resistance
P-Glycoprotein
Binding Sites
Pharmaceutical Preparations
Carrier Proteins
29 Citations (Scopus)

Influence of treatment of diabetic rats with combinations of pycnogenol, β-carotene, and α-lipoic acid on parameters of oxidative stress

Berryman, A. M., Maritim, A. C., Sanders, R. A. & Watkins, J. B., 2004, In : Journal of Biochemical and Molecular Toxicology. 18, 6, p. 345-352 8 p.

Research output: Contribution to journalArticle

Thioctic Acid
Oxidative stress
Carotenoids
Rats
Oxidative Stress
30 Citations (Scopus)

Isolation and culture of sensory neurons from the dorsal-root ganglia of embryonic or adult rats.

Burkey, T. H., Hingtgen, C. M. & Vasko, M., 2004, In : Methods in molecular medicine. 99, p. 189-202 14 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Sensory Receptor Cells
Physiological Phenomena
Pathologic Processes
Neurons
82 Citations (Scopus)

Loss of 14-3-3σ in Prostate Cancer and Its Precursors

Cheng, L., Pan, C. X., Zhang, J-T., Zhang, S., Kinch, M. S., Li, L., Baldridge, L. A., Wade, C., Hu, Z., Koch, M., Ulbright, T. & Eble, J., May 1 2004, In : Clinical Cancer Research. 10, 9, p. 3064-3068 5 p.

Research output: Contribution to journalArticle

Prostatic Intraepithelial Neoplasia
Prostatic Neoplasms
Prostate
Adenocarcinoma
Epithelium
64 Citations (Scopus)
ATP-Binding Cassette Transporters
Multiple Drug Resistance
Xenobiotics
Topotecan
Drug Therapy
34 Citations (Scopus)

New 2,4-Diamino-5-(2′,5′-substituted benzyl)pyrimidines as Potential Drugs against Opportunistic Infections of AIDS and Other Immune Disorders. Synthesis and Species-Dependent Antifolate Activity

Rosowsky, A., Forsch, R. A., Sibley, C. H., Inderlied, C. B. & Queener, S., Mar 11 2004, In : Journal of Medicinal Chemistry. 47, 6, p. 1475-1486 12 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pyrimidines
Tetrahydrofolate Dehydrogenase
Immune System Diseases
Opportunistic Infections
67 Citations (Scopus)
Nerve Growth Factor Receptor
Blocking Antibodies
Nerve Growth Factor
Sensory Receptor Cells
Nociceptors
58 Citations (Scopus)

Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control

Sullivan, W., Narasimhan, J., Bhatti, M. M. & Wek, R., Jun 1 2004, In : Biochemical Journal. 380, 2, p. 523-531 9 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Parasites
Phosphotransferases
Apicomplexa
Phosphorylation

Preface

Zhang, J-T., 2004, In : Current Medicinal Chemistry - Anti-Cancer Agents. 4, 1

Research output: Contribution to journalArticle

66 Citations (Scopus)
Pneumocystis carinii
Mycobacterium avium
Tetrahydrofolate Dehydrogenase
Trimethoprim
Inhibitory Concentration 50
30 Citations (Scopus)

RNA Helicase A in the MEF1 Transcription Factor Complex Up-regulates the MDR1 Gene in Multidrug-resistant Cancer Cells

Zhong, X. & Safa, A., Apr 23 2004, In : Journal of Biological Chemistry. 279, 17, p. 17134-17141 8 p.

Research output: Contribution to journalArticle

RNA Helicases
Transcription Factors
Up-Regulation
Genes
Cells
84 Citations (Scopus)

Role of eIF3 p170 in controlling synthesis of ribonucleotide reductase M2 and cell growth

Dong, Z., Liu, L. H., Han, B., Pincheira, R. & Zhang, J-T., May 6 2004, In : Oncogene. 23, 21, p. 3790-3801 12 p.

Research output: Contribution to journalArticle

Growth
Mimosine
Eukaryotic Initiation Factors
DNA
Lung Neoplasms
27 Citations (Scopus)
Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Stereochemistry
stereochemistry
38 Citations (Scopus)
Pneumocystis carinii
Mycobacterium avium
Tetrahydrofolate Dehydrogenase
Toxoplasma
Inhibitory Concentration 50
169 Citations (Scopus)

Taxol induces caspase-10-dependent apoptosis

Park, S. J., Wu, C. H., Gordon, J. D., Zhong, X., Emami, A. & Safa, A., Dec 3 2004, In : Journal of Biological Chemistry. 279, 49, p. 51057-51067 11 p.

Research output: Contribution to journalArticle

Caspase 10
Paclitaxel
Apoptosis
Death Domain Receptors
Caspase 8
92 Citations (Scopus)

The Biology and Pharmacology of Calcium Channel α2-δ Proteins Pfizer satellite symposium to the 2003 Society for Neuroscience Meeting Sheraton New Orleans Hotel New Orleans, LA November 10, 2003

Taylor, C. P., Catterall, W. A., Hofmann, F., Luo, Z. D., Wustrow, D. J., Vasko, M., Field, M. & Baron, S., Jun 2004, In : CNS Drug Reviews. 10, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

Calcium Channels
Pharmacology
Pharmaceutical Preparations
Anti-Anxiety Agents
Proteins
43 Citations (Scopus)
Peptide Elongation Factor 1
Proto-Oncogenes
Tumor Suppressor Genes
Non-Small Cell Lung Carcinoma
Proteomics
2003
4 Citations (Scopus)

7-Methyl trimethoprim analogues as inhibitors of the folate metabolizing enzymes

Gangjee, A., Lin, X. & Queener, S., May 2003, In : Journal of Heterocyclic Chemistry. 40, 3, p. 507-512 6 p.

Research output: Contribution to journalArticle

Pyrimidines
Tetrahydrofolate Dehydrogenase
Trimethoprim
Folic Acid
Benzaldehydes
234 Citations (Scopus)

Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes

Southall, M. D., Li, T., Gharibova, L. S., Pei, Y., Nicol, G. & Travers, J., Jan 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 304, 1, p. 217-222 6 p.

Research output: Contribution to journalArticle

Keratinocytes
Capsaicin
Cyclooxygenase 2
Skin
vanilloid receptor subtype 1
35 Citations (Scopus)

ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors

Huang, H., Wu, X., Nicol, G., Meller, S. & Vasko, M., Sep 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 3, p. 1137-1144 8 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Adenosine Triphosphate
Peptides
Capsaicin
Protein Kinase C
114 Citations (Scopus)

Calmodulin binds to the C terminus of sodium channels Nav1.4 and Navl.6 and differentially modulates their functional properties

Herzog, R. I., Liu, C., Waxman, S. G. & Cummins, T., Sep 10 2003, In : Journal of Neuroscience. 23, 23, p. 8261-8270 10 p.

Research output: Contribution to journalArticle

Sodium Channels
Calmodulin
Calcium
Voltage-Gated Sodium Channels
Neuronal Plasticity
1823 Citations (Scopus)

Diabetes, oxidative stress, and antioxidants: A review

Maritim, A. C., Sanders, R. A. & Watkins, J. B., 2003, In : Journal of Biochemical and Molecular Toxicology. 17, 1, p. 24-38 15 p.

Research output: Contribution to journalArticle

Oxidative stress
Medical problems
Oxidative Stress
Diabetes Complications
Antioxidants
73 Citations (Scopus)

Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats

Maritim, A., Dene, B. A., Sanders, R. A. & Watkins, J. B., 2003, In : Journal of Biochemical and Molecular Toxicology. 17, 3, p. 193-199 7 p.

Research output: Contribution to journalArticle

Oxidative stress
Streptozocin
Rats
Oxidative Stress
Body Weight