Pharmacology & Toxicology

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2004

Role of external pallidal segment in primate parkinsonism: Comparison of the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsionism and lesions of the external pallidal segment

Soares, J., Kliem, M. A., Betarbet, R., Greenamyre, J. T., Yamamoto, B. & Wichmann, T., Jul 21 2004, In : Journal of Neuroscience. 24, 29, p. 6417-6426 10 p.

Research output: Contribution to journalArticle

130 Scopus citations
28 Scopus citations
38 Scopus citations

Taxol induces caspase-10-dependent apoptosis

Park, S. J., Wu, C. H., Gordon, J. D., Zhong, X., Emami, A. & Safa, A. R., Dec 3 2004, In : Journal of Biological Chemistry. 279, 49, p. 51057-51067 11 p.

Research output: Contribution to journalArticle

170 Scopus citations

The Biology and Pharmacology of Calcium Channel α2-δ Proteins Pfizer satellite symposium to the 2003 Society for Neuroscience Meeting Sheraton New Orleans Hotel New Orleans, LA November 10, 2003

Taylor, C. P., Catterall, W. A., Hofmann, F., Luo, Z. D., Wustrow, D. J., Vasko, M., Field, M. & Baron, S., Jun 1 2004, In : CNS Drug Reviews. 10, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

95 Scopus citations
43 Scopus citations
2003

7-Methyl trimethoprim analogues as inhibitors of the folate metabolizing enzymes

Gangjee, A., Lin, X. & Queener, S. F., Jan 1 2003, In : Journal of Heterocyclic Chemistry. 40, 3, p. 507-512 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors

Huang, H., Wu, X., Nicol, G. D., Meller, S. & Vasko, M. R., Sep 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 3, p. 1137-1144 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Calmodulin binds to the C terminus of sodium channels Nav1.4 and Navl.6 and differentially modulates their functional properties

Herzog, R. I., Liu, C., Waxman, S. G. & Cummins, T. R., Sep 10 2003, In : Journal of Neuroscience. 23, 23, p. 8261-8270 10 p.

Research output: Contribution to journalArticle

Open Access
117 Scopus citations

Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats

Maritim, A., Dene, B. A., Sanders, R. A. & Watkins, J. B., Jul 18 2003, In : Journal of Biochemical and Molecular Toxicology. 17, 3, p. 193-199 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

Effects of α-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats

Maritim, A. C., Sanders, R. A. & Watkins, J. B., May 1 2003, In : Journal of Nutritional Biochemistry. 14, 5, p. 288-294 7 p.

Research output: Contribution to journalArticle

189 Scopus citations

EIF3 p170, a mediator of mimosine effect on protein synthesis and cell cycle progression

Dong, Z. & Zhang, J. T., Sep 1 2003, In : Molecular Biology of the Cell. 14, 9, p. 3942-3951 10 p.

Research output: Contribution to journalArticle

80 Scopus citations
36 Scopus citations
15 Scopus citations

Molecular cloning and characterization of an SRCAP chromatin remodeling homologue in Toxoplasma gondii

Sullivan, W. J., Monroy, M. A., Bohne, W., Nallani, K. C., Chrivia, J., Yaciuk, P., Smith, C. K. & Queener, S. F., May 1 2003, In : Parasitology Research. 90, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Oxidative Stress in Rats after 60 Days of Hypergalactosemia or Hyperglycemia

Otsyula, M., King, M. S., Ketcham, T. G., Sanders, R. A. & Watkins, J. B., Jan 1 2003, In : International Journal of Toxicology. 22, 6, p. 423-427 5 p.

Research output: Contribution to journalArticle

14 Scopus citations
275 Scopus citations

Prostaglandin E2 inhibits the potassium current in sensory neurons from hyperalgesic Kv1.1 knockout mice

Jiang, X., Zhang, Y. H., Clark, J. D., Tempel, B. L. & Nicol, G. D., Jun 18 2003, In : Neuroscience. 119, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)

Bhave, G., Hu, H. J., Glauner, K. S., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S. & Gereau IV, R. W., Oct 14 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 21, p. 12480-12485 6 p.

Research output: Contribution to journalArticle

301 Scopus citations

Regulation of constitutive expression of mouse PTEN by the 5′-untranslated region

Han, B., Dong, Z., Liu, Y., Chen, Q., Hashimoto, K. & Zhang, J. T., Aug 14 2003, In : Oncogene. 22, 34, p. 5325-5337 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

Synaptic and membrane properties of neurons in the dorsomedial hypothalamus

Bailey, T. W., Nicol, G. D., Schild, J. H. & DiMicco, J. A., Sep 26 2003, In : Brain research. 985, 2, p. 150-162 13 p.

Research output: Contribution to journalArticle

16 Scopus citations
55 Scopus citations

Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3-d]pyrimidines

Donkor, I. O., Li, H. & Queener, S. F., Jun 1 2003, In : European Journal of Medicinal Chemistry. 38, 6, p. 605-611 7 p.

Research output: Contribution to journalArticle

43 Scopus citations
89 Scopus citations

The exonuclease activity of human apurinic/apyrimidinic endonuclease (APE1). Biochemical properties and inhibition by the natural dinucleotide Gp4G

Chou, K. M. & Cheng, Y. C., May 16 2003, In : Journal of Biological Chemistry. 278, 20, p. 18289-18296 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Tight Control of Platelet-derived Growth Factor B/c-sis Expression by Interplay between the 5′-Untranslated Region Sequence and the Major Upstream Promoter

Han, B., Dong, Z. & Zhang, J. T., Nov 21 2003, In : Journal of Biological Chemistry. 278, 47, p. 46983-46993 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
28 Scopus citations
2002

An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3′ mispaired DNA

Chou, K. M. & Cheng, Y. C., Feb 7 2002, In : Nature. 415, 6872, p. 655-659 5 p.

Research output: Contribution to journalArticle

175 Scopus citations

cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation

Bhave, G., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S. & Gereau IV, R. W., Aug 15 2002, In : Neuron. 35, 4, p. 721-731 11 p.

Research output: Contribution to journalArticle

418 Scopus citations
132 Scopus citations

Characterization of anthracenediones and their photoaffinity analogs

Chou, K. M., Krapcho, A. P., Horn, D. & Hacker, M., Mar 15 2002, In : Biochemical Pharmacology. 63, 6, p. 1143-1147 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
66 Scopus citations

Cytoplasmic retraction of the amino terminus of human multidrug resistance protein 1

Chen, Q., Yang, Y., Liu, Y., Han, B. & Zhang, J. T., Jul 23 2002, In : Biochemistry. 41, 29, p. 9052-9062 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Dimerization of human XPA and formation of XPA2-RPA protein complex

Yang, Z. G., Liu, Y., Mao, L. Y., Zhang, J. T. & Zou, Y., Oct 29 2002, In : Biochemistry. 41, 43, p. 13012-13020 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Effects of combined Quercetin and coenzyme Q10 treatment on oxidative stress in normal and diabetic rats

Coldiron, A. D., Sanders, R. A. & Watkins, J. B., Oct 23 2002, In : Journal of Biochemical and Molecular Toxicology. 16, 4, p. 197-202 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Effects of β-carotene on oxidative stress in normal and diabetic rats

Maritim, A., Dene, B. A., Sanders, R. A. & Watkins, J. B., Oct 23 2002, In : Journal of Biochemical and Molecular Toxicology. 16, 4, p. 203-208 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs

Kilts, J. D., Connery, H. S., Arrington, E. G., Lewis, M. M., Lawler, C. P., Oxford, G. S., O'Malley, K. L., Todd, R. D., Blake, B. L., Nichols, D. E. & Mailman, R. B., Jun 17 2002, In : Journal of Pharmacology and Experimental Therapeutics. 301, 3, p. 1179-1189 11 p.

Research output: Contribution to journalArticle

66 Scopus citations

Impairment of slow inactivation as a common mechanism for periodic paralysis in dIIS4-S5

Bendahhou, S., Cummins, T. R., Kula, R. W., Fu, Y. H. & Ptácek, L. J., Apr 23 2002, In : Neurology. 58, 8, p. 1266-1272 7 p.

Research output: Contribution to journalArticle

59 Scopus citations
44 Scopus citations

Mechanism of β2- microglobulin-induced apoptosis in the K562 leukemia cell line, defective in major histocompatibility class 1

Wu, C. H., Gordon, J. D., Zhong, X. & Safa, A. R., Sep 1 2002, In : Anticancer Research. 22, 5, p. 2613-2621 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mechanisms of the release of anterogradely transported neurotrophin-3 from axon terminals

Wang, X., Butowt, R., Vasko, M. R. & Von Bartheld, C. S., Feb 1 2002, In : Journal of Neuroscience. 22, 3, p. 931-945 15 p.

Research output: Contribution to journalArticle

53 Scopus citations

Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant

Wu, C. H., Gordon, J., Rastegar, M., Ogretmen, B. & Safa, A. R., Jan 1 2002, In : Oncogene. 21, 33, p. 5160-5174 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regulation of gene expression by internal ribosome entry sites or cryptic promoters: The eIF4G story

Han, B. & Zhang, J. T., Nov 1 2002, In : Molecular and cellular biology. 22, 21, p. 7372-7384 13 p.

Research output: Contribution to journalArticle

95 Scopus citations

Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1

Yang, Y., Chen, Q. & Zhang, J. T., Nov 15 2002, In : Journal of Biological Chemistry. 277, 46, p. 44268-44277 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Structural studies on bioactive compounds. Part 36: Design, synthesis and biological evaluation of pyrimethamine-based antifolates against Pneumocystis carinii

Chan, D. C. M., Laughton, C. A., Queener, S. F. & Stevens, M. F. G., Jul 23 2002, In : Bioorganic and Medicinal Chemistry. 10, 9, p. 3001-3010 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Twenty-four hour exposure to prostaglandin downregulates prostanoid receptor binding but does not alter PGE2-mediated sensitization of rat sensory neurons

Southall, M. D., Bolyard, L. A. & Vasko, M. R., Apr 27 2002, In : Pain. 96, 3, p. 285-296 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2001

Changes in the kinetic parameters of hepatic γ-glutamyltransferase from streptozotocin-induced diabetic rats

Cornwell, P. D. & Watkins, J. B., Feb 9 2001, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1545, 1-2, p. 184-191 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Characterization of oxidative stress in various tissues of diabetic and galactose-fed rats

Strother, R. M., Thomas, T. G., Otsyula, M., Sanders, R. A. & Watkins, J. B., Jan 1 2001, In : International Journal of Experimental Diabetes Research. 2, 3, p. 211-216 6 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Conformationally restricted tricyclic analogues of lipophilic pyrido[2, 3-d]pyrimidine antifolates [1a, b]

Gangjee, A., Mavandadi, F. & Queener, S. F., Jan 1 2001, In : Journal of Heterocyclic Chemistry. 38, 1, p. 213-220 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from pneumocystis carinii

Graffner-Nordberg, M., Kolmodin, K., Åqvist, J., Queener, S. F. & Hallberg, A., Jul 19 2001, In : Journal of Medicinal Chemistry. 44, 15, p. 2391-2402 12 p.

Research output: Contribution to journalArticle

84 Scopus citations