Pharmacology & Toxicology

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1996

Impaired slow inactivation in mutant sodium channels

Cummins, T. R. & Sigworth, F. J., Jul 1996, In : Biophysical journal. 71, 1, p. 227-236 10 p.

Research output: Contribution to journalArticle

Open Access
148 Scopus citations

Lovastatin effects of human breast carcinoma cells. Differential toxicity of an adriamycin-resistant derivative and influence on selenocysteine tRNAs

Diamond, A. M., Jaffe, D., Murray, J. L., Safa, A. R., Samuels, B. L. & Hatfield, D. L., Aug 20 1996, In : Biochemistry and Molecular Biology International. 38, 2, p. 345-355 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes

Chen, M. & Zhang, J. T., Jan 1 1996, In : Molecular Membrane Biology. 13, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Membrane integration of in vitro-translated gap junctional proteins: Co- and post-translational mechanisms

Zhang, J. T., Chen, M., Foote, C. I. & Nicholson, B. J., Mar 1996, In : Molecular Biology of the Cell. 7, 3, p. 471-482 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

Methamphetamine pretreatment and the vulnerability of the striatum to methamphetamine neurotoxicity

Stephans, S. & Yamamoto, B., Jun 1996, In : Neuroscience. 72, 3, p. 593-600 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Minimal effect of acute experimental hepatitis induced by lipopolysaccharide/D-galactosamine on biotransformation in rats

Omar, H. E. D. M., Sanders, R. A. & Watkins, J. B., Dec 24 1996, In : Biochemical Pharmacology. 52, 12, p. 1921-1924 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mitochondrial ADP/ATP carrier can be reversibly converted into a large channel by Ca2+

Brustovetsky, N. & Klingenberg, M., Aug 1 1996, In : Biochemistry. 35, 26, p. 8483-8488 6 p.

Research output: Contribution to journalArticle

361 Scopus citations

Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii

Gangjee, A., Zhu, Y., Queener, S. F., Francom, P. & Broom, A. D., Apr 26 1996, In : Journal of Medicinal Chemistry. 39, 9, p. 1836-1845 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Pentamidine congeners. 4. DNA binding affinity and anti-Pneumocystis carinii activity of butamidine analogues

Donkor, I. O., Queener, S. F. & Dalton, J. T., Aug 20 1996, In : Bioorganic and Medicinal Chemistry Letters. 6, 16, p. 1967-1970 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Peptidase inhibitors improve recovery of substance P and calcitonin gene-related peptide release from rat spinal cord slices

Chen, J. J., Barber, L. A., Dymshitz, J. & Vasko, M. R., Jan 1 1996, In : Peptides. 17, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Pharmacokinetic modulation of irinotecan and metabolites by cyclosporin A

Gupta, E., Safa, A. R., Wang, X. & Ratain, M. J., Mar 15 1996, In : Cancer Research. 56, 6, p. 1309-1314 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

pH regulation in single CA1 neurons acutely isolated from the hippocampi of immature and mature rats

Bevensee, M. O., Cummins, T. R., Haddad, G. G., Boron, W. F. & Boyarsky, G., Jul 15 1996, In : Journal of Physiology. 494, 2, p. 315-328 14 p.

Research output: Contribution to journalArticle

71 Scopus citations
3 Scopus citations

Reversal of multi-drug resistance in vitro by fatty acid-PEG-fatty acid diesters

Buckingham, L. E., Balasubramanian, M., Safa, A. R., Shah, H., Komarov, P., Emanuele, R. M. & Coon, J. S., Jan 3 1996, In : International Journal of Cancer. 65, 1, p. 74-79 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Ring-based analogues of pentamidine versus P. carinii pneumonia in culture

Delia, T. J., Nagarajan, A., Queener, S. F. & Bartlet, M. S., Oct 8 1996, In : Bioorganic and Medicinal Chemistry Letters. 6, 19, p. 2367-2370 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Semisynthetic echinocandins affect cell wall deposition of Pneumocystis carinii in vitro and in vivo

Bartlett, M. S., Current, W. L., Goheen, M. P., Boylan, C. J., Lee, C. H., Shaw, M. M., Queener, S. F. & Smith, J. W., Aug 1 1996, In : Antimicrobial Agents and Chemotherapy. 40, 8, p. 1811-1816 6 p.

Research output: Contribution to journalArticle

51 Scopus citations
30 Scopus citations

Site-directed mutagenesis by unique site elimination using filamentous phage-derived ssDNA templates for plasmids that are resistant to denaturation

Ogretmen, B., Carpo, C. & Safa, A. R., Aug 1 1996, In : BioTechniques. 21, 2, p. 209-213 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Sulfa resistance in mouse-derived Pneumocystis carinii

Lane, B., Hossler, P., Bartlett, M., Queener, S., O'Reelly, T., Smith, J. & Meshnick, S., Sep 1 1996, In : Journal of Eukaryotic Microbiology. 43, 5, p. 39S

Research output: Contribution to journalArticle

5 Scopus citations

Synthesis and anti-Pneumocystis carinii activity of piperidine-linked aromatic diimidazolines

Huang, T. L., Zhang, Q., White, A. T., Queener, S. F., Bartlett, M. S., Smith, J. W. & Donkor, I. O., Sep 3 1996, In : Bioorganic and Medicinal Chemistry Letters. 6, 17, p. 2087-2090 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Synthesis of a Series of Diaminobenzo[f]- And Diaminobenzo[h]pyrimido[4,5-b]quinolines as 5-Deaza Tetracyclic Nonclassical Antifolates

Donkor, I. O., Devraj, R., Queener, S. F., Barrows, L. R. & Gangjee, A., Jan 1 1996, In : Journal of Heterocyclic Chemistry. 33, 6, p. 1653-1661 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Topological folding and proteolysis profile of P-glycoprotein in membranes of multidrug-resistant cells: Implications for the drug-transport mechanism

Zhang, M., Wang, G., Shapiro, A. & Zhang, J. T., Sep 25 1996, In : Biochemistry. 35, 30, p. 9728-9736 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Types of Pneumocystis carinii detected in air samples

Bartlett, M. S., Lu, J. J., Lee, C. H., Durant, P. J., Queener, S. F. & Smith, J. W., Sep 1 1996, In : Journal of Eukaryotic Microbiology. 43, 5, p. 44S

Research output: Contribution to journalArticle

17 Scopus citations
1997

2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Rosowsky, A., Papoulis, A. T. & Queener, S. F., Nov 11 1997, In : Journal of Medicinal Chemistry. 40, 22, p. 3694-3699 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Action of zolpidem on responses to GABA in relation to mRNAs for GABA(A) receptor alpha subunits within single cells: Evidence for multiple functional GABA(A) isoreceptors on individual neurons

Criswell, H. E., McCown, T. J., Moy, S. S., Oxford, G. S., Mueller, R. A., Morrow, A. L. & Breese, G. R., Jan 1 1997, In : Neuropharmacology. 36, 11-12, p. 1641-1652 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Activation and recovery of the PGE2-mediated sensitization of the capsaicin response in rat sensory neurons

Lopshire, J. C. & Nicol, G. D., Dec 1997, In : Journal of Neurophysiology. 78, 6, p. 3154-3164 11 p.

Research output: Contribution to journalArticle

67 Scopus citations

Animation of intestinal absorption, enterohepatic circulation and intestinal and renal elimination

Watkins, J. B., Dec 1 1997, In : FASEB Journal. 11, 3, p. A221

Research output: Contribution to journalArticle

Biochemical and physical parameters of the electrical currents measured with the ADP/ATP carrier by photolysis of caged ADP and ATP

Broustovetsky, N., Bamberg, E., Gropp, T. & Klingenberg, M., Nov 11 1997, In : Biochemistry. 36, 45, p. 13865-13872 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Characterization of an amino-terminal fragment of the bacteriophage T4 uvsY recombination protein

Yassa, D. S., Chou, K. M. & Morrical, S. W., May 1997, In : Biochimie. 79, 5, p. 275-285 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Circumvention of P-GP MDR as a function of anthracycline lipophilicity and charge

Lampidis, T. J., Kolonias, D., Podona, T., Israel, M., Safa, A. R., Lothstein, L., Savaraj, N., Tapiero, H. & Priebe, W., Mar 4 1997, In : Biochemistry. 36, 9, p. 2679-2685 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate

Cody, V., Galitsky, N., Luft, J. R., Pangborn, W., Gangjee, A., Devraj, R., Queener, S. F. & Blakley, R. L., Jan 1 1997, In : Acta Crystallographica Section D: Biological Crystallography. 53, 6, p. 638-649 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

Conformational changes of P-glycoprotein by nucleotide binding

Wang, G., Pincheira, R., Zhang, M. & Zhang, J. T., Dec 15 1997, In : Biochemical Journal. 328, 3, p. 897-904 8 p.

Research output: Contribution to journalArticle

56 Scopus citations
49 Scopus citations

Construction of bivalent vaccine candidate expressing CS3 fimbriae and cholera toxin B subunit

Dong, Z., Li, S. & Zhang, Z., Sep 1 1997, In : Chinese Journal of Microbiology and Immunology. 17, 5, p. 348-351 4 p.

Research output: Contribution to journalArticle

456 Scopus citations
25 Scopus citations
Open Access
85 Scopus citations

Hepatobiliary excretion of bile acids and rose bengal in streptozotocin- induced and genetic diabetic rats

Stone, J. L., Braunstein, J. B., Beaty, T. M., Sanders, R. A. & Watkins, J. B., May 24 1997, In : Journal of Pharmacology and Experimental Therapeutics. 281, 1, p. 412-419 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Identification of vimentin as a primaquine-binding protein from pneumocystis cakinii

Queener, S. F. & Bolvard, L. A., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1269

Research output: Contribution to journalArticle

IMP dehydrogenase from Pneumocystis carinii as a potential drug target

O'Gara, M. J., Lee, C. H., Weinberg, G. A., Nott, J. M. & Queener, S. F., Jan 1 1997, In : Antimicrobial Agents and Chemotherapy. 41, 1, p. 40-48 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone

Isenberg, J. S., Kolaja, K. L., Ayoubi, S. A., Watkins, J. B. & Klaunig, J. E., Aug 1 1997, In : Carcinogenesis. 18, 8, p. 1511-1519 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Insertion of a SNS-specific tetrapeptide in S3-S4 linker of D4 accelerates recovery from inactivation of skeletal muscle voltage-gated Na channel μ1 in HEK293 cells

Dib-Hajj, S. D., Ishikawa, K., Cummins, T. R. & Waxman, S. G., Oct 13 1997, In : FEBS Letters. 416, 1, p. 11-14 4 p.

Research output: Contribution to journalArticle

42 Scopus citations
198 Scopus citations

In vitro and in vivo models of Pneumocystis carinii

Bartlett, M. S., Queener, S. F., Shaw, M. M., Durant, P. J., Lee, C. H. & Smith, J. W., Nov 1 1997, In : Journal of Eukaryotic Microbiology. 44, 6, p. 51S

Research output: Contribution to journalArticle

4 Scopus citations

Mechanism of modulation of the voltage-gated skeletal and cardiac muscle sodium channels by fatty acids

Bendahhou, S., Cummins, T. R. & Agnew, W. S., Feb 1 1997, In : American Journal of Physiology - Cell Physiology. 272, 2 41-2, p. C592-C600

Research output: Contribution to journalArticle

55 Scopus citations

Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: Activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents

Robson, C., Meek, M. A., Grunwaldt, J. D., Lambert, P. A., Queener, S. F., Schmidt, D. & Griffin, R. J., Sep 26 1997, In : Journal of Medicinal Chemistry. 40, 19, p. 3040-3048 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases

Olopade, O. I., Adeyanju, M. O., Safa, A. R., Hagos, F., Mick, R., Thompson, C. B. & Recant, W. M., Aug 19 1997, In : Cancer Journal from Scientific American. 3, 4, p. 230-237 8 p.

Research output: Contribution to journalArticle

187 Scopus citations

Oxygen deprivation inhibits Na+ current in rat hippocampal neurones via protein kinase C

O'Reilly, J. P., Cummins, T. R. & Haddad, G. G., Sep 15 1997, In : Journal of Physiology. 503, 3, p. 479-488 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Prostaglandins suppress an outward potassium current in embryonic rat sensory neurons

Nicol, G. D., Vasko, M. R. & Evans, A. R., Jan 1 1997, In : Journal of Neurophysiology. 77, 1, p. 167-176 10 p.

Research output: Contribution to journalArticle

107 Scopus citations

Regulation of opioid receptors in rat sensory neurons in culture

Chen, J. J., Dymshitz, J. & Vasko, M. R., Apr 1997, In : Molecular Pharmacology. 51, 4, p. 666-673 8 p.

Research output: Contribution to journalArticle

36 Scopus citations