Pharmacology & Toxicology

Publications 1970 2020

Filter
Article
1996
147 Citations (Scopus)

Impaired slow inactivation in mutant sodium channels

Cummins, T. R. & Sigworth, F. J., Jul 1996, In : Biophysical Journal. 71, 1, p. 227-236 10 p.

Research output: Contribution to journalArticle

Open Access
Hyperkalemic Periodic Paralysis
Sodium Channels
Mutation
Sodium
Muscles
12 Citations (Scopus)

Lovastatin effects of human breast carcinoma cells. Differential toxicity of an adriamycin-resistant derivative and influence on selenocysteine tRNAs

Diamond, A. M., Jaffe, D., Murray, J. L., Safa, A. R., Samuels, B. L. & Hatfield, D. L., Aug 20 1996, In : Biochemistry and Molecular Biology International. 38, 2, p. 345-355 11 p.

Research output: Contribution to journalArticle

Lovastatin
Doxorubicin
Toxicity
MCF-7 Cells
Cells
20 Citations (Scopus)

Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes

Chen, M. & Zhang, J. T., Jan 1 1996, In : Molecular Membrane Biology. 13, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Membranes
P-Glycoprotein
Signal Recognition Particle
ATP-Binding Cassette Transporters
67 Citations (Scopus)

Membrane integration of in vitro-translated gap junctional proteins: Co- and post-translational mechanisms

Zhang, J. T., Chen, M., Foote, C. I. & Nicholson, B. J., Mar 1996, In : Molecular Biology of the Cell. 7, 3, p. 471-482 12 p.

Research output: Contribution to journalArticle

Connexins
Membranes
Gap Junctions
Proteins
trans-Golgi Network
56 Citations (Scopus)

Methamphetamine pretreatment and the vulnerability of the striatum to methamphetamine neurotoxicity

Stephans, S. & Yamamoto, B., Jun 1996, In : Neuroscience. 72, 3, p. 593-600 8 p.

Research output: Contribution to journalArticle

Methamphetamine
Dopamine
Serotonin
Glutamic Acid
Prefrontal Cortex
12 Citations (Scopus)

Minimal effect of acute experimental hepatitis induced by lipopolysaccharide/D-galactosamine on biotransformation in rats

Omar, H. E. D. M., Sanders, R. A. & Watkins, J. B., Dec 24 1996, In : Biochemical Pharmacology. 52, 12, p. 1921-1924 4 p.

Research output: Contribution to journalArticle

Galactosamine
Biotransformation
Hepatitis
Lipopolysaccharides
Rats
360 Citations (Scopus)

Mitochondrial ADP/ATP carrier can be reversibly converted into a large channel by Ca2+

Brustovetsky, N. & Klingenberg, M., Aug 1 1996, In : Biochemistry. 35, 26, p. 8483-8488 6 p.

Research output: Contribution to journalArticle

ATP Translocases Mitochondrial ADP
Bongkrekic Acid
Ligands
Porins
Cardiolipins
30 Citations (Scopus)

Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii

Gangjee, A., Zhu, Y., Queener, S. F., Francom, P. & Broom, A. D., Apr 26 1996, In : Journal of Medicinal Chemistry. 39, 9, p. 1836-1845 10 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Toxoplasma
Liver
Rats
10 Citations (Scopus)

Pentamidine congeners. 4. DNA binding affinity and anti-Pneumocystis carinii activity of butamidine analogues

Donkor, I. O., Queener, S. F. & Dalton, J. T., Aug 20 1996, In : Bioorganic and Medicinal Chemistry Letters. 6, 16, p. 1967-1970 4 p.

Research output: Contribution to journalArticle

Pentamidine
Pneumocystis carinii
DNA
Aromatic compounds
butamidine
33 Citations (Scopus)

Peptidase inhibitors improve recovery of substance P and calcitonin gene-related peptide release from rat spinal cord slices

Chen, J. J., Barber, L. A., Dymshitz, J. & Vasko, M. R., Jan 1 1996, In : Peptides. 17, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
phenylalanylalanine
Substance P
Protease Inhibitors
Rats
81 Citations (Scopus)

Pharmacokinetic modulation of irinotecan and metabolites by cyclosporin A

Gupta, E., Safa, A. R., Wang, X. & Ratain, M. J., Mar 15 1996, In : Cancer Research. 56, 6, p. 1309-1314 6 p.

Research output: Contribution to journalArticle

irinotecan
Cyclosporine
Pharmacokinetics
P-Glycoprotein
71 Citations (Scopus)

pH regulation in single CA1 neurons acutely isolated from the hippocampi of immature and mature rats

Bevensee, M. O., Cummins, T. R., Haddad, G. G., Boron, W. F. & Boyarsky, G., Jul 15 1996, In : Journal of Physiology. 494, 2, p. 315-328 14 p.

Research output: Contribution to journalArticle

Hippocampus
Neurons
Buffers
Acids
Normal Distribution
3 Citations (Scopus)
terminal care
assisted suicide
medical ethics
physician
35 Citations (Scopus)

Reversal of multi-drug resistance in vitro by fatty acid-PEG-fatty acid diesters

Buckingham, L. E., Balasubramanian, M., Safa, A. R., Shah, H., Komarov, P., Emanuele, R. M. & Coon, J. S., Jan 3 1996, In : International Journal of Cancer. 65, 1, p. 74-79 6 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Fatty Acids
P-Glycoprotein
Surface-Active Agents
Ethylene Oxide
7 Citations (Scopus)

Ring-based analogues of pentamidine versus P. carinii pneumonia in culture

Delia, T. J., Nagarajan, A., Queener, S. F. & Bartlet, M. S., Oct 8 1996, In : Bioorganic and Medicinal Chemistry Letters. 6, 19, p. 2367-2370 4 p.

Research output: Contribution to journalArticle

Pentamidine
Benzene
Pneumonia
Molecules
pyridine
50 Citations (Scopus)

Semisynthetic echinocandins affect cell wall deposition of Pneumocystis carinii in vitro and in vivo

Bartlett, M. S., Current, W. L., Goheen, M. P., Boylan, C. J., Lee, C. H., Shaw, M. M., Queener, S. F. & Smith, J. W., Aug 1 1996, In : Antimicrobial Agents and Chemotherapy. 40, 8, p. 1811-1816 6 p.

Research output: Contribution to journalArticle

Echinocandins
Pneumocystis carinii
Cell Wall
anidulafungin
Pneumocystis Pneumonia
30 Citations (Scopus)
P-Glycoprotein
Dissection
Membrane Proteins
Membranes
Amino Acid Sequence
1 Citation (Scopus)

Site-directed mutagenesis by unique site elimination using filamentous phage-derived ssDNA templates for plasmids that are resistant to denaturation

Ogretmen, B., Carpo, C. & Safa, A. R., Aug 1 1996, In : BioTechniques. 21, 2, p. 209-213 5 p.

Research output: Contribution to journalArticle

Genetic Templates
Bacteriophage M13
Nucleic Acid Denaturation
Mutagenesis
Denaturation
5 Citations (Scopus)

Sulfa resistance in mouse-derived Pneumocystis carinii

Lane, B., Hossler, P., Bartlett, M., Queener, S., O'Reelly, T., Smith, J. & Meshnick, S., Sep 1 1996, In : Journal of Eukaryotic Microbiology. 43, 5, p. 39S

Research output: Contribution to journalArticle

Molecular Sequence Data
Dihydropteroate Synthase
Pneumocystis
Sulfamethoxazole
Pneumocystis carinii
17 Citations (Scopus)

Synthesis and anti-Pneumocystis carinii activity of piperidine-linked aromatic diimidazolines

Huang, T. L., Zhang, Q., White, A. T., Queener, S. F., Bartlett, M. S., Smith, J. W. & Donkor, I. O., Sep 3 1996, In : Bioorganic and Medicinal Chemistry Letters. 6, 17, p. 2087-2090 4 p.

Research output: Contribution to journalArticle

Pentamidine
Pneumocystis carinii
Pharmaceutical Preparations
Growth
piperidine
10 Citations (Scopus)

Synthesis of a Series of Diaminobenzo[f]- And Diaminobenzo[h]pyrimido[4,5-b]quinolines as 5-Deaza Tetracyclic Nonclassical Antifolates

Donkor, I. O., Devraj, R., Queener, S. F., Barrows, L. R. & Gangjee, A., Nov 1 1996, In : Journal of Heterocyclic Chemistry. 33, 6, p. 1653-1660 8 p.

Research output: Contribution to journalArticle

Quinolines
Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Liver
Rats
46 Citations (Scopus)

Topological folding and proteolysis profile of P-glycoprotein in membranes of multidrug-resistant cells: Implications for the drug-transport mechanism

Zhang, M., Wang, G., Shapiro, A. & Zhang, J. T., Sep 25 1996, In : Biochemistry. 35, 30, p. 9728-9736 9 p.

Research output: Contribution to journalArticle

Proteolysis
P-Glycoprotein
Membranes
Pharmaceutical Preparations
Topology
17 Citations (Scopus)

Types of Pneumocystis carinii detected in air samples

Bartlett, M. S., Lu, J. J., Lee, C. H., Durant, P. J., Queener, S. F. & Smith, J. W., Sep 1 1996, In : Journal of Eukaryotic Microbiology. 43, 5, p. 44S

Research output: Contribution to journalArticle

Mycological Typing Techniques
Air Microbiology
Pneumocystis
Pneumocystis carinii
Patients' Rooms
1997
42 Citations (Scopus)

2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Rosowsky, A., Papoulis, A. T. & Queener, S. F., Nov 11 1997, In : Journal of Medicinal Chemistry. 40, 22, p. 3694-3699 6 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
Inhibitory Concentration 50
24 Citations (Scopus)

Action of zolpidem on responses to GABA in relation to mRNAs for GABA(A) receptor alpha subunits within single cells: Evidence for multiple functional GABA(A) isoreceptors on individual neurons

Criswell, H. E., McCown, T. J., Moy, S. S., Oxford, G. S., Mueller, R. A., Morrow, A. L. & Breese, G. R., Jan 1 1997, In : Neuropharmacology. 36, 11-12, p. 1641-1652 12 p.

Research output: Contribution to journalArticle

GABA-A Receptors
gamma-Aminobutyric Acid
Neurons
Messenger RNA
zolpidem
67 Citations (Scopus)

Activation and recovery of the PGE2-mediated sensitization of the capsaicin response in rat sensory neurons

Lopshire, J. C. & Nicol, G. D., Dec 1997, In : Journal of Neurophysiology. 78, 6, p. 3154-3164 11 p.

Research output: Contribution to journalArticle

Capsaicin
Sensory Receptor Cells
Dinoprostone
Cyclic GMP
Protein Kinases

Animation of intestinal absorption, enterohepatic circulation and intestinal and renal elimination

Watkins, J. B., Dec 1 1997, In : FASEB Journal. 11, 3, p. A221

Research output: Contribution to journalArticle

Enterohepatic Circulation
intestinal absorption
Intestinal Absorption
Animation
students
11 Citations (Scopus)

Biochemical and physical parameters of the electrical currents measured with the ADP/ATP carrier by photolysis of caged ADP and ATP

Broustovetsky, N., Bamberg, E., Gropp, T. & Klingenberg, M., Nov 11 1997, In : Biochemistry. 36, 45, p. 13865-13872 8 p.

Research output: Contribution to journalArticle

ATP Translocases Mitochondrial ADP
Photolysis
Adenosine Diphosphate
Bongkrekic Acid
Fluxes
22 Citations (Scopus)

Characterization of an amino-terminal fragment of the bacteriophage T4 uvsY recombination protein

Yassa, D. S., Chou, K. M. & Morrical, S. W., May 1997, In : Biochimie. 79, 5, p. 275-285 11 p.

Research output: Contribution to journalArticle

Bacteriophages
Genetic Recombination
Proteins
Genetic Phenomena
Bacteriophage T4
67 Citations (Scopus)

Circumvention of P-GP MDR as a function of anthracycline lipophilicity and charge

Lampidis, T. J., Kolonias, D., Podona, T., Israel, M., Safa, A. R., Lothstein, L., Savaraj, N., Tapiero, H. & Priebe, W., Mar 4 1997, In : Biochemistry. 36, 9, p. 2679-2685 7 p.

Research output: Contribution to journalArticle

Anthracyclines
Mitochondria
Doxorubicin
Modulators
Cytoplasm
44 Citations (Scopus)

Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate

Cody, V., Galitsky, N., Luft, J. R., Pangborn, W., Gangjee, A., Devraj, R., Queener, S. F. & Blakley, R. L., Jan 1 1997, In : Acta Crystallographica Section D: Biological Crystallography. 53, 6, p. 638-649 12 p.

Research output: Contribution to journalArticle

coenzymes
Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Coenzymes
56 Citations (Scopus)

Conformational changes of P-glycoprotein by nucleotide binding

Wang, G., Pincheira, R., Zhang, M. & Zhang, J. T., Dec 15 1997, In : Biochemical Journal. 328, 3, p. 897-904 8 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Nucleotides
Adenosine Triphosphate
Proteolysis
Ligands
48 Citations (Scopus)
Folic Acid Antagonists
Pneumocystis carinii
Purines
Trimethoprim
Toxoplasma

Construction of bivalent vaccine candidate expressing CS3 fimbriae and cholera toxin B subunit

Dong, Z., Li, S. & Zhang, Z., Sep 1 1997, In : Chinese Journal of Microbiology and Immunology. 17, 5, p. 348-351 4 p.

Research output: Contribution to journalArticle

Cholera Toxin
Vaccines
Toxoids
Enterotoxigenic Escherichia coli
Antigens
455 Citations (Scopus)
Axotomy
Tetrodotoxin
Sensory Receptor Cells
Up-Regulation
Down-Regulation
25 Citations (Scopus)
Pneumocystis carinii
Pyrimidines
Tetrahydrofolate Dehydrogenase
Methylation
Toxoplasma
85 Citations (Scopus)
Open Access
Tumor Suppressor Protein p53
MCF-7 Cells
Breast Neoplasms
Codon
Multiple Drug Resistance
15 Citations (Scopus)

Hepatobiliary excretion of bile acids and rose bengal in streptozotocin- induced and genetic diabetic rats

Stone, J. L., Braunstein, J. B., Beaty, T. M., Sanders, R. A. & Watkins, J. B., May 24 1997, In : Journal of Pharmacology and Experimental Therapeutics. 281, 1, p. 412-419 8 p.

Research output: Contribution to journalArticle

Rose Bengal
Streptozocin
Bile Acids and Salts
Bile
Wistar Rats

Identification of vimentin as a primaquine-binding protein from pneumocystis cakinii

Queener, S. F. & Bolvard, L. A., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1269

Research output: Contribution to journalArticle

Pneumocystis
Primaquine
vimentin
Vimentin
binding proteins
30 Citations (Scopus)

IMP dehydrogenase from Pneumocystis carinii as a potential drug target

O'Gara, M. J., Lee, C. H., Weinberg, G. A., Nott, J. M. & Queener, S. F., Jan 1 1997, In : Antimicrobial Agents and Chemotherapy. 41, 1, p. 40-48 9 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Pneumocystis carinii
Pharmaceutical Preparations
Mycophenolic Acid
Escherichia coli
30 Citations (Scopus)

Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone

Isenberg, J. S., Kolaja, K. L., Ayoubi, S. A., Watkins, J. B. & Klaunig, J. E., Aug 1 1997, In : Carcinogenesis. 18, 8, p. 1511-1519 9 p.

Research output: Contribution to journalArticle

Rotenone
Liver
Growth
Diet
DNA
42 Citations (Scopus)

Insertion of a SNS-specific tetrapeptide in S3-S4 linker of D4 accelerates recovery from inactivation of skeletal muscle voltage-gated Na channel μ1 in HEK293 cells

Dib-Hajj, S. D., Ishikawa, K., Cummins, T. R. & Waxman, S. G., Oct 13 1997, In : FEBS Letters. 416, 1, p. 11-14 4 p.

Research output: Contribution to journalArticle

HEK293 Cells
Muscle
Skeletal Muscle
Recovery
Kinetics
198 Citations (Scopus)
Sodium-Hydrogen Antiporter
Proton-Translocating ATPases
Calcineurin
Cell membranes
Yeast
4 Citations (Scopus)

In vitro and in vivo models of Pneumocystis carinii

Bartlett, M. S., Queener, S. F., Shaw, M. M., Durant, P. J., Lee, C. H. & Smith, J. W., Nov 1 1997, In : Journal of Eukaryotic Microbiology. 44, 6, p. 51S

Research output: Contribution to journalArticle

Pneumocystis
Animal Disease Models
Pneumocystis carinii
Pneumocystis Pneumonia
Antifungal Agents
55 Citations (Scopus)

Mechanism of modulation of the voltage-gated skeletal and cardiac muscle sodium channels by fatty acids

Bendahhou, S., Cummins, T. R. & Agnew, W. S., Feb 1 1997, In : American Journal of Physiology - Cell Physiology. 272, 2 41-2, p. C592-C600

Research output: Contribution to journalArticle

Sodium Channels
Oleic Acids
Arachidonic Acids
Muscle
Myocardium
31 Citations (Scopus)

Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: Activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents

Robson, C., Meek, M. A., Grunwaldt, J. D., Lambert, P. A., Queener, S. F., Schmidt, D. & Griffin, R. J., Sep 26 1997, In : Journal of Medicinal Chemistry. 40, 19, p. 3040-3048 9 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
Antineoplastic Agents
186 Citations (Scopus)

Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases

Olopade, O. I., Adeyanju, M. O., Safa, A. R., Hagos, F., Mick, R., Thompson, C. B. & Recant, W. M., Aug 19 1997, In : Cancer Journal from Scientific American. 3, 4, p. 230-237 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Proteins
Proto-Oncogene Proteins c-bcl-2
58 Citations (Scopus)

Oxygen deprivation inhibits Na+ current in rat hippocampal neurones via protein kinase C

O'Reilly, J. P., Cummins, T. R. & Haddad, G. G., Sep 15 1997, In : Journal of Physiology. 503, 3, p. 479-488 10 p.

Research output: Contribution to journalArticle

Protein Kinase C
Oxygen
Neurons
Phosphotransferases
Cyclic AMP-Dependent Protein Kinases
106 Citations (Scopus)

Prostaglandins suppress an outward potassium current in embryonic rat sensory neurons

Nicol, G. D., Vasko, M. R. & Evans, A. R., Jan 1 1997, In : Journal of Neurophysiology. 77, 1, p. 167-176 10 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Prostaglandins
Potassium
Dinoprostone
Neurons
36 Citations (Scopus)

Regulation of opioid receptors in rat sensory neurons in culture

Chen, J. J., Dymshitz, J. & Vasko, M. R., Apr 1997, In : Molecular Pharmacology. 51, 4, p. 666-673 8 p.

Research output: Contribution to journalArticle

Diprenorphine
Opioid Receptors
Sensory Receptor Cells
Ala(2)-MePhe(4)-Gly(5)-enkephalin
Opioid Analgesics