Pharmacology & Toxicology

Publications 1971 2020

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18 Citations (Scopus)

Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons

Barbosa, C., Tan, Z. Y., Wang, R., Xie, W., Strong, J. A., Patel, R. R., Vasko, M., Zhang, J. M. & Cummins, T., Sep 25 2015, In : Molecular Pain. 11, 1, 60.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Spinal Ganglia
Sodium
Neurons
Voltage-Gated Sodium Channels
Neuropeptides
Cysteine
Neurotransmitter Agents
Rats
dynorphin (1-8)
10 Citations (Scopus)

Nerve growth factor, sphingomyelins, and sensitization in sensory neurons

Nicol, G., Oct 25 2008, In : Sheng li xue bao : [Acta physiologica Sinica]. 60, 5, p. 603-604 2 p.

Research output: Contribution to journalArticle

Sphingomyelins
Nerve Growth Factor
Sensory Receptor Cells
Ceramides
Sphingosine
5 Citations (Scopus)

Nerve growth factor/p75 neurotrophin receptor-mediated sensitization of rat sensory neurons depends on membrane cholesterol

Zhang, Y. H., Khanna, R. & Nicol, G., Sep 17 2013, In : Neuroscience. 248, p. 562-570 9 p.

Research output: Contribution to journalArticle

Nerve Growth Factor Receptor
Nerve Growth Factor
Sensory Receptor Cells
Cholesterol
Membranes
4 Citations (Scopus)

Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons

Pittman, S. K., Gracias, N. G. & Fehrenbacher, J., May 1 2016, In : Experimental Neurology. 279, p. 104-115 12 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Sensory Receptor Cells
Neurites
Microtubules
Paclitaxel
24 Citations (Scopus)

Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKMζ

Zhang, Y. H., Kays, J., Hodgdon, K. E., Sacktor, T. C. & Nicol, G., Jan 2012, In : Journal of Neurophysiology. 107, 1, p. 315-335 21 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Sensory Receptor Cells
Protein Isoforms
Phosphatidylinositol 3-Kinase
Small Interfering RNA
12 Citations (Scopus)

Nerve growth factor mediates a switch in intracellular signaling for PGE<inf>2</inf>-induced sensitization of sensory neurons from protein kinase A to Epac

Vasko, M., Habashy Malty, R., Guo, C., Duarte, D. B., Zhang, Y. & Nicol, G., Aug 15 2014, In : PLoS One. 9, 8, e104529.

Research output: Contribution to journalArticle

nerve growth factor
cAMP-dependent protein kinase
sensory neurons
Nerve Growth Factor
Sensory Receptor Cells
59 Citations (Scopus)

Neuroprotection against traumatic brain Injury by a peptide derived from the Collapsin Response Mediator Protein 2 (CRMP2)

Brittain, J. M., Chen, L., Wilson, S. M., Brustovetsky, T., Gao, X., Ashpole, N. M., Molosh, A. I., You, H., Hudmon, A., Shekhar, A., White, F., Zamponi, G. W., Broustovetski, N., Chen, J. & Khanna, R., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37778-37792 15 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Brain
Peptides
Neurons
Human Immunodeficiency Virus Proteins
9 Citations (Scopus)

Neuroprotective effect of KB-r7943 against glutamate excitotoxicity is related to mild mitochondrial depolarization

Storozhevykh, T. P., Senilova, Y. E., Brustovetsky, T., Pinelis, V. G. & Broustovetski, N., Feb 2010, In : Neurochemical Research. 35, 2, p. 323-335 13 p.

Research output: Contribution to journalArticle

Depolarization
Neuroprotective Agents
Glutamic Acid
Kainic Acid
Neurons
Methamphetamine
Dopaminergic Neurons
Alcohols
Drinking
Dopamine Plasma Membrane Transport Proteins
34 Citations (Scopus)

New 2,4-Diamino-5-(2′,5′-substituted benzyl)pyrimidines as Potential Drugs against Opportunistic Infections of AIDS and Other Immune Disorders. Synthesis and Species-Dependent Antifolate Activity

Rosowsky, A., Forsch, R. A., Sibley, C. H., Inderlied, C. B. & Queener, S., Mar 11 2004, In : Journal of Medicinal Chemistry. 47, 6, p. 1475-1486 12 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pyrimidines
Tetrahydrofolate Dehydrogenase
Immune System Diseases
Opportunistic Infections
73 Citations (Scopus)
Pneumocystis
Pneumocystis Pneumonia
Drug Design
Opportunistic Infections
Structure-Activity Relationship
98 Citations (Scopus)

New rat model of Pneumocystis carinii infection

Bartlett, M. S., Fishman, J. A., Queener, S., Durkin, M. M., Jay, M. A. & Smith, J. W., 1988, In : Journal of Clinical Microbiology. 26, 6, p. 1100-1102 3 p.

Research output: Contribution to journalArticle

Pneumocystis Infections
Pneumocystis carinii
Injections
Pneumocystis Pneumonia
Infection
38 Citations (Scopus)

NF-κB: Regulation by methylation

Lu, T. & Stark, G. R., Sep 15 2015, In : Cancer Research. 75, 18, p. 3692-3695 4 p.

Research output: Contribution to journalArticle

Methylation
Lysine
Arginine
Neoplasms
Mutation
67 Citations (Scopus)
Nerve Growth Factor Receptor
Blocking Antibodies
Nerve Growth Factor
Sensory Receptor Cells
Nociceptors
19 Citations (Scopus)

Nitric oxide and cyclic guanosine 3',5'-monophosphate do not alter neuropeptide release from rat sensory neurons grown in culture

Dymshitz, J. & Vasko, M., 1994, In : Neuroscience. 62, 4, p. 1279-1286 8 p.

Research output: Contribution to journalArticle

Guanosine Monophosphate
Cyclic GMP
Sensory Receptor Cells
Neuropeptides
Capsaicin
31 Citations (Scopus)

Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: Activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents

Robson, C., Meek, M. A., Grunwaldt, J. D., Lambert, P. A., Queener, S., Schmidt, D. & Griffin, R. J., 1997, In : Journal of Medicinal Chemistry. 40, 19, p. 3040-3048 9 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Tetrahydrofolate Dehydrogenase
Toxoplasma
Antineoplastic Agents
22 Citations (Scopus)

Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: Synthesis and biological activities

Gangjee, A., Zaveri, N., Kothare, M. & Queener, S., 1995, In : Journal of Medicinal Chemistry. 38, 18, p. 3660-3668 9 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Toxoplasma
Bioactivity
Tumors
30 Citations (Scopus)

Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii

Gangjee, A., Zhu, Y., Queener, S., Francom, P. & Broom, A. D., Apr 26 1996, In : Journal of Medicinal Chemistry. 39, 9, p. 1836-1845 10 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Pneumocystis carinii
Toxoplasma
Liver
Rats
55 Citations (Scopus)

Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases

Gangjee, A., Mavandadi, F., Queener, S. & McGuire, J. J., 1995, In : Journal of Medicinal Chemistry. 38, 12, p. 2158-2165 8 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
Methotrexate
Liver
Rats
49 Citations (Scopus)

Novel boron-containing, nonclassical antifolates: Synthesis and preliminary biological and structural evaluation

Reynolds, R. C., Campbell, S. R., Fairchild, R. G., Kisliuk, R. L., Micca, P. L., Queener, S., Riordan, J. M., Sedwick, W. D., Waud, W. R., Leung, A. K. W., Dixon, R. W., Suling, W. J. & Borhani, D. W., Jul 12 2007, In : Journal of Medicinal Chemistry. 50, 14, p. 3283-3289 7 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Boron
Lactobacillus casei
Tumors
Mycobacterium avium
14 Citations (Scopus)
Folic Acid Antagonists
Pyrimidines
Carbon
Pneumocystis carinii
Mycobacterium avium
9 Citations (Scopus)

Novel serine 176 phosphorylation of YBX1 activates NF-κB in colon cancer

Martin, M., Hua, L., Wang, B., Wei, H., Prabhu, L., Hartley, A. V., Jiang, G., Liu, Y. & Lu, T., Feb 24 2017, In : Journal of Biological Chemistry. 292, 8, p. 3433-3444 12 p.

Research output: Contribution to journalArticle

Y-Box-Binding Protein 1
Phosphorylation
Colonic Neoplasms
Serine
Neoplasms
5 Citations (Scopus)

Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth

Li, X., Ma, H., Li, L., Chen, Y., Sun, X., Dong, Z., Liu, J. Y., Zhu, W. & Zhang, J-T., May 1 2018, In : Oncogene. 37, 18, p. 2469-2480 12 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
src Homology Domains
Alkaloids
Heterografts
Transcriptional Activation
60 Citations (Scopus)

N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons

Rimmerman, N., Bradshaw, H. B., Hughes, H. V., Chen, J. S. C., Hu, S. S. J., McHugh, D., Vefring, E., Jahnsen, J. A., Thompson, E. L., Masuda, K., Cravatt, B. F., Burstein, S., Vasko, M., Prieto, A. L., O'Dell, D. K. & Walker, J. M., Jul 2008, In : Molecular Pharmacology. 74, 1, p. 213-224 12 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Glycine
Nitric Oxide
Lipids
Calcium
28 Citations (Scopus)

NPY y 1 receptors differentially modulate gaba a and nmda receptors via divergent signal-transduction pathways to reduce excitability of amygdala neurons

Molosh, A. I., Sajdyk, T. J., Truitt, W., Zhu, W., Oxford, G. S. & Shekhar, A., Jun 2013, In : Neuropsychopharmacology. 38, 7, p. 1352-1364 13 p.

Research output: Contribution to journalArticle

N-Methylaspartate
Amygdala
Signal Transduction
gamma-Aminobutyric Acid
Inhibitory Postsynaptic Potentials
9 Citations (Scopus)

N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1 +/- mice

Duan, J. H., Hodgdon, K. E., Hingtgen, C. M. & Nicol, G., Jun 13 2014, In : Neuroscience. 270, p. 192-202 11 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Calcium
Calcitonin Gene-Related Peptide
Genotype
Substance P
16 Citations (Scopus)

Oligomeric BAX induces mitochondrial permeability transition and complete cytochrome c release without oxidative stress

Li, T., Brustovetsky, T., Antonsson, B. & Broustovetski, N., Nov 2008, In : Biochimica et Biophysica Acta - Bioenergetics. 1777, 11, p. 1409-1421 13 p.

Research output: Contribution to journalArticle

Oxidative stress
Cytochromes c
Alamethicin
Permeability
Mitochondrial Swelling
51 Citations (Scopus)

Oligomerization domain of the multidrug resistance-associated transporter ABCG2 and its dominant inhibitory activity

Xu, J., Peng, H., Chen, Q., Liu, Y., Dong, Z. & Zhang, J-T., May 1 2007, In : Cancer Research. 67, 9, p. 4373-4381 9 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Drug Resistance
ATP-Binding Cassette Transporters
HEK293 Cells
Neoplasms
16 Citations (Scopus)

Oligomerization of human ATP-binding cassette transporters and its potential significance in human disease

Mo, W. & Zhang, J-T., Sep 2009, In : Expert Opinion on Drug Metabolism and Toxicology. 5, 9, p. 1049-1063 15 p.

Research output: Contribution to journalArticle

Oligomerization
ATP-Binding Cassette Transporters
Chemotherapy
Multiple Drug Resistance
Pharmaceutical Preparations
14 Citations (Scopus)

One-step synthesis of novel 2,4-diaminopyrimidine antifolates from bridged alicyclic ketones and cyanoguanidine

Rosowsky, A., Papoulis, A. T. & Queener, S., May 1999, In : Journal of Heterocyclic Chemistry. 36, 3, p. 723-728 6 p.

Research output: Contribution to journalArticle

Folic Acid Antagonists
Ketones
Carbon
Tetrahydrofolate Dehydrogenase
Trimethoprim

On the lipolytic action of parathyroid hormone (PTH) in man

Sinha, T. K., Thajchayapong, P. & Queener, S., 1975, In : Clinical Research. 23, 3

Research output: Contribution to journalArticle

Parathyroid Hormone
31 Citations (Scopus)

On the lipolytic action of parathyroid hormone in man

Sinha, T. K., Thajchayapong, P., Queener, S., Allen, D. O. & Bell, N. H., 1976, In : Metabolism: Clinical and Experimental. 25, 3, p. 251-260 10 p.

Research output: Contribution to journalArticle

Lipolysis
Parathyroid Hormone
Pseudohypoparathyroidism
Adenosine
Fats

On the lipolytic action of parathyroid hormone in man

Sinha, T. K., Thajchayapong, P. & Queener, S., 1975, In : Clinical Research. 23, 1

Research output: Contribution to journalArticle

Parathyroid Hormone
13 Citations (Scopus)

Overexpression of asparagine synthetase and matrix metalloproteinase 19 confers cisplatin sensitivity in nasopharyngeal carcinoma cells

Liu, R. Y., Dong, Z., Liu, J., Zhou, L., Huang, W., Khoo, S. K., Zhang, Z., Petillo, D., Teh, B. T., Qian, C. N. & Zhang, J-T., Oct 2013, In : Molecular Cancer Therapeutics. 12, 10, p. 2157-2166 10 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
Cisplatin
Chorionic Gonadotropin
Platinum
Gene Expression Profiling
15 Citations (Scopus)

Oxidative metabolism and Ca2+ handling in isolated brain mitochondria and striatal neurons from R6/2 mice, a model of Huntington's disease

Hamilton, J., Pellman, J. J., Brustovetsky, T., Harris, R. & Broustovetski, N., 2016, In : Human Molecular Genetics. 25, 13, p. 2762-2775 14 p.

Research output: Contribution to journalArticle

Corpus Striatum
Huntington Disease
Mitochondria
Neurons
Brain
6 Citations (Scopus)

Oxidative metabolism and Ca2+ handling in striatal mitochondria from YAC128 mice, a model of Huntington's disease

Hamilton, J., Brustovetsky, T. & Broustovetski, N., Nov 21 2016, (Accepted/In press) In : Neurochemistry International.

Research output: Contribution to journalArticle

Corpus Striatum
Huntington Disease
Mitochondria
Respiration
Pathology
22 Citations (Scopus)

Oxidative metabolism in YAC128 mouse model of Huntington's disease

Hamilton, J., Pellman, J. J., Brustovetsky, T., Harris, R. & Broustovetski, N., 2015, In : Human Molecular Genetics. 24, 17, p. 4862-4878 17 p.

Research output: Contribution to journalArticle

Huntington Disease
Corpus Striatum
Neurons
Mitochondria
Respiration
14 Citations (Scopus)
Monensin
Toxoplasma
Oxidative Stress
Parasites
Antioxidants
14 Citations (Scopus)

Oxidative Stress in Rats after 60 Days of Hypergalactosemia or Hyperglycemia

Otsyula, M., King, M. S., Ketcham, T. G., Sanders, R. A. & Watkins, J. B., Nov 2003, In : International Journal of Toxicology. 22, 6, p. 423-427 5 p.

Research output: Contribution to journalArticle

Oxidative stress
Hyperglycemia
Rats
Oxidative Stress
Streptozocin
14 Citations (Scopus)

Paclitaxel alters the evoked release of calcitonin gene-related peptide from rat sensory neurons in culture

Pittman, S. K., Gracias, N. G., Vasko, M. & Fehrenbacher, J., Mar 2014, In : Experimental Neurology. 253, p. 146-153 8 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
Sensory Receptor Cells
Paclitaxel
Capsaicin
Peripheral Nervous System Diseases
2 Citations (Scopus)
Calcitonin Gene-Related Peptide
Sensory Receptor Cells
Paclitaxel
Membranes
Phorbol 12,13-Dibutyrate
9 Citations (Scopus)

Painful research: Identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels

Rush, A. M. & Cummins, T., Aug 2007, In : Molecular Interventions. 7, 4, p. 192-195 4 p.

Research output: Contribution to journalArticle

Aniline Compounds
Sodium Channel Blockers
Furans
Sodium Channels
Neurons
37 Citations (Scopus)

Pair of unusual GCN5 histone acetyltransferases and ADA2 homologues in the protozoan parasite Toxoplasma gondii

Bhatti, M. M., Livingston, M., Mullapudi, N. & Sullivan, W., Jan 2006, In : Eukaryotic Cell. 5, 1, p. 62-76 15 p.

Research output: Contribution to journalArticle

Toxoplasma
Toxoplasma gondii
Protozoa
Parasites
Eukaryota
3 Citations (Scopus)

Paracetamol pharmacokinetics are independent of caloric intake and physical activity

Yiamouyiannis, C. A., Harris, A., Sanders, R. A., Martin, B. J. & Watkins, J. B., 1994, In : Drug Investigation. 8, 6, p. 361-368 8 p.

Research output: Contribution to journalArticle

Acetaminophen
Energy Intake
Pharmacokinetics
Exercise
Volunteers
59 Citations (Scopus)

Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control

Sullivan, W., Narasimhan, J., Bhatti, M. M. & Wek, R., Jun 1 2004, In : Biochemical Journal. 380, 2, p. 523-531 9 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Parasites
Phosphotransferases
Apicomplexa
Phosphorylation
85 Citations (Scopus)

Paroxysmal extreme pain disorder M1627K mutation in human Nav 1.7 renders DRG neurons hyperexcitable

Dib-Hajj, S. D., Estacion, M., Jarecki, B. W., Tyrrell, L., Fischer, T. Z., Lawden, M., Cummins, T. & Waxman, S. G., Sep 19 2008, In : Molecular Pain. 4, 37.

Research output: Contribution to journalArticle

Diagnosis-Related Groups
Neurons
Mutation
Pain
NAV1.7 Voltage-Gated Sodium Channel
58 Citations (Scopus)

Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation

Jarecki, B. W., Sheets, P., Jackson, J. O. & Cummins, T., 2008, In : Journal of Physiology. 586, 17, p. 4137-4153 17 p.

Research output: Contribution to journalArticle

Mutation
NAV1.7 Voltage-Gated Sodium Channel
Paroxysmal Extreme Pain Disorder
Somatoform Disorders
Missense Mutation
18 Citations (Scopus)

Pentobarbital sleeping time and waking blood levels in spontaneously hypertensive rats

Willis, L. R. & Queener, S. F., 1977, In : Canadian Journal of Physiology and Pharmacology. 55, 5, p. 1205-1207 3 p.

Research output: Contribution to journalArticle

Metabolic Clearance Rate
Inbred SHR Rats
Pentobarbital
Sleep
Hypertension
33 Citations (Scopus)

Peptidase inhibitors improve recovery of substance P and calcitonin gene-related peptide release from rat spinal cord slices

Chen, J. J., Barber, L. A., Dymshitz, J. & Vasko, M., 1996, In : Peptides. 17, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
phenylalanylalanine
Substance P
Protease Inhibitors
Rats