Pharmacology & Toxicology

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Review article
2020

Emerging Therapeutic Targets Against Toxoplasma gondii: Update on DNA Repair Response Inhibitors and Genotoxic Drugs

Angel, S. O., Vanagas, L., Ruiz, D. M., Cristaldi, C., Saldarriaga Cartagena, A. M. & Sullivan, W. J., Jun 12 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 289.

Research output: Contribution to journalReview article

Open Access

Modulating the modulators: regulation of protein arginine methyltransferases by post-translational modifications

Hartley, A. V. & Lu, T., 2020, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalReview article

Open Access

No pain, no gain? The effects of pain-promoting neuropeptides and neurotrophins on fracture healing

Sun, S., Diggins, N. H., Gunderson, Z. J., Fehrenbacher, J. C., White, F. A. & Kacena, M. A., Feb 2020, In : Bone. 131, 115109.

Research output: Contribution to journalReview article

3 Scopus citations
2019

PRMTs and miRNAs: functional cooperation in cancer and beyond

Jin, J., Martin, M., Hartley, A. V. & Lu, T., Aug 3 2019, In : Cell Cycle. 18, 15, p. 1676-1686 11 p.

Research output: Contribution to journalReview article

1 Scopus citations
2018

Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we?

Beebe, J. D., Liu, J. Y. & Zhang, J. T., Nov 2018, In : Pharmacology and Therapeutics. 191, p. 74-91 18 p.

Research output: Contribution to journalReview article

35 Scopus citations
2017

Bromodomains in protozoan parasites: Evolution, function, and opportunities for drug development

Jeffers, V., Yang, C., Huang, S. & Sullivan, W., Mar 1 2017, In : Microbiology and Molecular Biology Reviews. 81, 1, e00047-16.

Research output: Contribution to journalReview article

13 Scopus citations

Targeting survivin for therapeutic discovery: past, present, and future promises

Peery, R. C., Liu, J. Y. & Zhang, J. T., Oct 2017, In : Drug Discovery Today. 22, 10, p. 1466-1477 12 p.

Research output: Contribution to journalReview article

30 Scopus citations

The serine/threonine phosphatases of apicomplexan parasites

Yang, C. & Arrizabalaga, G., Oct 2017, In : Molecular Microbiology. 106, 1, p. 1-21 21 p.

Research output: Contribution to journalReview article

2 Scopus citations

Translational Control in the Latency of Apicomplexan Parasites

Holmes, M. J., Augusto, L. D. S., Zhang, M., Wek, R. C. & Sullivan, W. J., Dec 2017, In : Trends in Parasitology. 33, 12, p. 947-960 14 p.

Research output: Contribution to journalReview article

17 Scopus citations
2016

Emerging targets for glioblastoma stem cell therapy

Safa, A. R., Saadatzadeh, M. R., Cohen-Gadol, A. A., Pollok, K. E. & Bijangi-Vishehsaraei, K., 2016, In : Journal of Biomedical Research. 30, 1, p. 19-31 13 p.

Research output: Contribution to journalReview article

21 Scopus citations

Mutant Huntingtin and Elusive Defects in Oxidative Metabolism and Mitochondrial Calcium Handling

Brustovetsky, N., Jul 1 2016, In : Molecular Neurobiology. 53, 5, p. 2944-2953 10 p.

Research output: Contribution to journalReview article

21 Scopus citations

Targeting microenvironment in cancer therapeutics

Martin, M., Wei, H. & Lu, T., Aug 1 2016, In : Oncotarget. 7, 32, p. 52575-52583 9 p.

Research output: Contribution to journalReview article

31 Scopus citations
2015

Glioblastoma stem cells (GSCs) epigenetic plasticity and interconversion between differentiated non-GSCs and GSCs

Safa, A. R., Saadatzadeh, M. R., Cohen-Gadol, A. A., Pollok, K. E. & Bijangi-Vishehsaraei, K., Jun 1 2015, In : Genes and Diseases. 2, 2, p. 152-163 12 p.

Research output: Contribution to journalReview article

78 Scopus citations

Methamphetamine effects on blood-brain barrier structure and function

Northrop, N. A. & Yamamoto, B. K., Jan 1 2015, In : Frontiers in Neuroscience. 9, MAR, 69.

Research output: Contribution to journalReview article

49 Scopus citations

Role of post-translational modification of the Y box binding protein 1 in human cancers

Prabhu, L., Hartley, A. V., Martin, M., Warsame, F., Sun, E. & Lu, T., Sep 1 2015, In : Genes and Diseases. 2, 3, p. 240-246 7 p.

Research output: Contribution to journalReview article

8 Scopus citations
2014

Critical role of NF-κB in pancreatic cancer

Prabhu, L., Mundade, R., Korc, M., Loehrer, P. J. & Lu, T., Jan 1 2014, In : Oncotarget. 5, 22, p. 10969-10975 7 p.

Research output: Contribution to journalReview article

Open Access
68 Scopus citations

Molecular mechanisms of fatty acid synthase (FASN)-mediated resistance to anti-cancer treatments

Wu, X., Qin, L., Fako, V. & Zhang, J. T., Jan 1 2014, In : Advances in Biological Regulation. 54, 1, p. 214-221 8 p.

Research output: Contribution to journalReview article

34 Scopus citations

Role of ChIP-seq in the discovery of transcription factor binding sites, differential gene regulation mechanism, epigenetic marks and beyond

Mundade, R., Ozer, H. G., Wei, H., Prabhu, L. & Lu, T., Sep 15 2014, In : Cell Cycle. 13, 18, p. 2847-2852 6 p.

Research output: Contribution to journalReview article

53 Scopus citations
2013

MirNAS and their putative roles in the development and progression of Parkinson's disease

Wong, G. & Nass, R., 2013, In : Frontiers in Genetics. 3, JAN, Article 315.

Research output: Contribution to journalReview article

9 Scopus citations

Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain

Salvemini, D., Doyle, T., Kress, M. & Nicol, G., Feb 1 2013, In : Trends in Pharmacological Sciences. 34, 2, p. 110-118 9 p.

Research output: Contribution to journalReview article

31 Scopus citations

The role of TRP channels in migraine

Oxford, G. S. & Hurley, J. H., Apr 18 2013, In : Open Pain Journal. 6, SPEC.ISSUE.1, p. 37-49 13 p.

Research output: Contribution to journalReview article

8 Scopus citations

Translational control in Plasmodium and Toxoplasma parasites

Zhang, M., Joyce, B. R., Sullivan, W. J. & Nussenzweig, V., Feb 1 2013, In : Eukaryotic Cell. 12, 2, p. 161-167 7 p.

Research output: Contribution to journalReview article

40 Scopus citations
2012

c-FLIP, a master anti-apoptotic regulator

Safa, A. R., Sep 1 2012, In : Experimental Oncology. 34, 3, p. 176-184 9 p.

Research output: Contribution to journalReview article

167 Scopus citations

Human ABCG2: Structure, function, and its role in multidrug resistance

Mo, W. & Zhang, J. T., Apr 18 2012, In : International Journal of Biochemistry and Molecular Biology. 3, 1, p. 1-27 27 p.

Research output: Contribution to journalReview article

135 Scopus citations

Mechanisms of Toxoplasma gondii persistence and latency

Sullivan, W. J. & Jeffers, V., May 1 2012, In : FEMS Microbiology Reviews. 36, 3, p. 717-733 17 p.

Research output: Contribution to journalReview article

117 Scopus citations

Toxoplasma histone acetylation remodelers as novel drug targets

Vanagas, L., Jeffers, V., Bogado, S. S., Dalmasso, M. C., Sullivan, W. J. & Angel, S. O., Oct 1 2012, In : Expert Review of Anti-Infective Therapy. 10, 10, p. 1189-1201 13 p.

Research output: Contribution to journalReview article

21 Scopus citations
2011

DNA polymerase eta and chemotherapeutic agents

Chou, K. M., Jun 15 2011, In : Antioxidants and Redox Signaling. 14, 12, p. 2521-2529 9 p.

Research output: Contribution to journalReview article

12 Scopus citations

Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: From discovery to clinical application

Yin, J. & Zhang, J., Oct 1 2011, In : Journal of Central South University (Medical Sciences). 36, 10, p. 927-938 12 p.

Research output: Contribution to journalReview article

24 Scopus citations

Role of interleukins, IGF and stem cells in BPH

McLaren, I. D., Jerde, T. J. & Bushman, W., Nov 1 2011, In : Differentiation. 82, 4-5, p. 237-243 7 p.

Research output: Contribution to journalReview article

33 Scopus citations

Targeting the anti-apoptotic protein c-FLIP for cancer therapy

Safa, A. R. & Pollok, K. E., Jun 1 2011, In : Cancers. 3, 2, p. 1639-1671 33 p.

Research output: Contribution to journalReview article

95 Scopus citations

Translational control gone awry: A new mechanism of tumorigenesis and novel targets of cancer treatments

Yin, J. Y., Dong, Z., Liu, Z. Q. & Zhang, J. T., Feb 1 2011, In : Bioscience Reports. 31, 1, p. 1-15 15 p.

Research output: Contribution to journalReview article

32 Scopus citations

Translation control is critical during acute and chronic stages of toxoplasmosis infection

Joyce, B. R., Konrad, C., Wek, R. C. & Sullivan, W. J., Jan 2011, In : Expert Review of Anti-Infective Therapy. 9, 1, p. 1-3 3 p.

Research output: Contribution to journalReview article

Open Access
10 Scopus citations
2010

A decade of epigenetic research in Toxoplasma gondii

Dixon, S. E., Stilger, K. L., Elias, E. V., Naguleswaran, A. & Sullivan, W. J., Sep 1 2010, In : Molecular and Biochemical Parasitology. 173, 1, p. 1-9 9 p.

Research output: Contribution to journalReview article

43 Scopus citations

Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker

Liu, H., Liu, J. Y., Wu, X. & Zhang, J. T., Dec 1 2010, In : International Journal of Biochemistry and Molecular Biology. 1, 1, p. 69-89 21 p.

Research output: Contribution to journalReview article

86 Scopus citations

Sodium channels in normal and pathological pain

Dib-Hajj, S. D., Cummins, T. R., Black, J. A. & Waxman, S. G., Sep 29 2010, In : Annual Review of Neuroscience. 33, p. 325-347 23 p.

Research output: Contribution to journalReview article

396 Scopus citations
2009

14-3-3σ, the double-edged sword of human cancers

Li, Z., Liu, J. Y. & Zhang, J. T., Sep 18 2009, In : American Journal of Translational Research. 1, 4, p. 326-340 15 p.

Research output: Contribution to journalReview article

46 Scopus citations

Oligomerization of human ATP-binding cassette transporters and its potential significance in human disease

Mo, W. & Zhang, J. T., Sep 1 2009, In : Expert Opinion on Drug Metabolism and Toxicology. 5, 9, p. 1049-1063 15 p.

Research output: Contribution to journalReview article

16 Scopus citations

Peripheral mechanisms of pain and analgesia

Stein, C., Clark, J. D., Oh, U., Vasko, M. R., Wilcox, G. L., Overland, A. C., Vanderah, T. W. & Spencer, R. H., Apr 1 2009, In : Brain Research Reviews. 60, 1, p. 90-113 24 p.

Research output: Contribution to journalReview article

174 Scopus citations

Voltage-gated sodium channels in pain states: Role in pathophysiology and targets for treatment

Dib-Hajj, S. D., Binshtok, A. M., Cummins, T. R., Jarvis, M. F., Samad, T. & Zimmermann, K., Apr 1 2009, In : Brain Research Reviews. 60, 1, p. 65-83 19 p.

Research output: Contribution to journalReview article

101 Scopus citations
2008

Caenorhabditis elegans in Parkinson's disease drug discovery: Addressing an unmet medical need

Nass, R., Merchant, K. M. & Ryan, T., Dec 1 2008, In : Molecular Interventions. 8, 6, p. 284-293 10 p.

Research output: Contribution to journalReview article

31 Scopus citations

Cellular FLICE-like inhibitory protein (C-FLIP): A novel target for cancer therapy

Safa, A. R., Day, T. W. & Wu, C. H., Feb 1 2008, In : Current cancer drug targets. 8, 1, p. 37-46 10 p.

Research output: Contribution to journalReview article

136 Scopus citations
2007

Biochemistry and pharmacology of the human multidrug resistance gene product, ABCG2

Zhang, J. T., Aug 1 2007, In : Journal of Central South University (Medical Sciences). 32, 4, p. 531-541 11 p.

Research output: Contribution to journalReview article

13 Scopus citations

From genes to pain: Nav1.7 and human pain disorders

Dib-Hajj, S. D., Cummins, T. R., Black, J. A. & Waxman, S. G., Nov 1 2007, In : Trends in Neurosciences. 30, 11, p. 555-563 9 p.

Research output: Contribution to journalReview article

193 Scopus citations

Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy

Xu, J., Peng, H. & Zhang, J. T., Mar 1 2007, In : Current Medicinal Chemistry. 14, 6, p. 689-701 13 p.

Research output: Contribution to journalReview article

35 Scopus citations

Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons

Rush, A. M., Cummins, T. R. & Waxman, S. G., Feb 15 2007, In : Journal of Physiology. 579, 1, p. 1-14 14 p.

Research output: Contribution to journalReview article

262 Scopus citations

Painful research: Identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels

Rush, A. M. & Cummins, T. R., Aug 1 2007, In : Molecular Interventions. 7, 4, p. 192-195 4 p.

Research output: Contribution to journalReview article

10 Scopus citations

Role of calcium in volume-activated chloride currents in a mouse cholangiocyte cell line

Chen, B., Nicol, G. & Cho, W. K., Jan 1 2007, In : Journal of Membrane Biology. 215, 1, p. 1-13 13 p.

Research output: Contribution to journalReview article

15 Scopus citations

The roles of sodium channels in nociception: Implications for mechanisms of pain

Cummins, T. R., Sheets, P. L. & Waxman, S. G., Oct 1 2007, In : Pain. 131, 3, p. 243-257 15 p.

Research output: Contribution to journalReview article

340 Scopus citations

Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: On or off the trks?

Nicol, G. D. & Vasko, M. R., Feb 1 2007, In : Molecular Interventions. 7, 1, p. 26-41 16 p.

Research output: Contribution to journalReview article

117 Scopus citations
34 Scopus citations