Cardiothoracic Surgery

2008

VEGF is critical for stem cell-mediated cardioprotection and a crucial paracrine factor for defining the age threshold in adult and neonatal stem cell function

Markel, T. A., Wang, Y., Herrmann, J. L., Crisostomo, P. R., Wang, M., Novotny, N. M., Herring, C. M., Tan, J., Lahm, T. & Meldrum, D. R., Dec 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 295, 6

Research output: Contribution to journal › Article

Adult Stem Cells

Age Factors

Vascular Endothelial Growth Factor A

Stem Cells

Mesenchymal Stromal Cells

7 Citations (Scopus)

Ventricular assist device implantation in the pediatric population: Does pump size selection and associated hemodynamics impact outcomes?

Husain, S. A., Wallis, G., Fricker, F. J., Bleiweis, M. S., Staples, E. D., Klodell, C. T., Brown, J. & Turrentine, M., Sep 2008, In : ASAIO Journal. 54, 5, p. 474-478 5 p.

Research output: Contribution to journal › Article

Pediatrics

Heart-Assist Devices

Hemodynamics

Blood

Pumps

2007

32 Citations (Scopus)

Activation of individual tumor necrosis factor receptors differentially affects stem cell growth factor and cytokine production

Markel, T. A., Crisostomo, P. R., Wang, M., Herring, C. M. & Meldrum, D. R., Oct 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 293, 4

Research output: Contribution to journal › Article

Stem Cell Factor

Tumor Necrosis Factor Receptors

Intercellular Signaling Peptides and Proteins

Vascular Endothelial Growth Factor A

Cytokines

6 Citations (Scopus)

A novel biomarker for the detection of esophageal adenocarcinoma

Hammoud, Z. T., Badve, S., Saxena, R., Kesler, K., Rieger, K., Malkas, L. H. & Hickey, R. J., Jan 2007, In : Journal of Thoracic and Cardiovascular Surgery. 133, 1, p. 82-87 6 p.

Research output: Contribution to journal › Article

Proliferating Cell Nuclear Antigen

Adenocarcinoma

Biomarkers

Neoplasms

Staining and Labeling

1 Citation (Scopus)

A woman with facial papules and pulmonary nodules

Erickson, B. W., Cripe, L., Rieger, K., Cummings, O. & Wilkes, D., Jul 2007, In : Respiration. 74, 4, p. 471-474 4 p.

Research output: Contribution to journal › Article

Lymphomatoid Granulomatosis

X Ray Computed Tomography

Bronchoscopy

Exanthema

Lung Diseases

31 Citations (Scopus)

Deficiency of TNFR1 protects myocardium through SOCS3 and IL-6 but not p38 MAPK or IL-1β

Wang, M., Markel, T., Crisostomo, P., Herring, C., Meldrum, K. K., Lillemoe, K. D. & Meldrum, D. R., Apr 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 4

Research output: Contribution to journal › Article

Receptors, Tumor Necrosis Factor, Type I

p38 Mitogen-Activated Protein Kinases

Interleukin-1

Interleukin-6

Myocardium

9 Citations (Scopus)

Diagnosis of Esophageal Adenocarcinoma by Serum Proteomic Pattern

Hammoud, Z. T., Dobrolecki, L., Kesler, K., Rahmani, E., Rieger, K., Malkas, L. H. & Hickey, R. J., Aug 2007, In : Annals of Thoracic Surgery. 84, 2, p. 384-392 9 p.

Research output: Contribution to journal › Article

Proteomics

Adenocarcinoma

Serum

Biomarkers

Lasers

50 Citations (Scopus)

Endogenous estrogen attenuates pulmonary artery vasoreactivity and acute hypoxic pulmonary vasoconstriction: The effects of sex and menstrual cycle

Lahm, T., Patel, K. M., Crisostomo, P. R., Markel, T. A., Wang, M., Herring, C. & Meldrum, D. R., Sep 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 293, 3

Research output: Contribution to journal › Article

Menstrual Cycle

Vasoconstriction

Pulmonary Artery

Estrogens

Vasoconstrictor Agents

48 Citations (Scopus)

Endothelial STAT3 plays a critical role in generalized myocardial proinflammatory and proapoptotic signaling

Wang, M., Zhang, W., Crisostomo, P., Markel, T., Meldrum, K. K., Fu, X. Y. & Meldrum, D. R., Oct 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 293, 4

Research output: Contribution to journal › Article

Endothelial Cells

Knockout Mice

Reperfusion

Ischemia

Apoptosis

66 Citations (Scopus)

Fontan Operation: A Comparison of Lateral Tunnel with Extracardiac Conduit

Fiore, A. C., Turrentine, M., Rodefeld, M., Vijay, P., Schwartz, T. L., Virgo, K. S., Fischer, L. K. & Brown, J., Feb 2007, In : Annals of Thoracic Surgery. 83, 2, p. 622-630 9 p.

Research output: Contribution to journal › Article

Fontan Procedure

montirelin

Nervous System

Heterotaxy Syndrome

Hypoplastic Left Heart Syndrome

87 Citations (Scopus)

Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: Role of the 55 kDa TNF receptor (TNFR1)

Crisostomo, P. R., Wang, M., Herring, C. M., Markel, T. A., Meldrum, K. K., Lillemoe, K. D. & Meldrum, D. R., Jan 2007, In : Journal of Molecular and Cellular Cardiology. 42, 1, p. 142-149 8 p.

Research output: Contribution to journal › Article

Tumor Necrosis Factor Receptors

Mesenchymal Stromal Cells

Vascular Endothelial Growth Factor A

Interleukin-6

Apoptosis

33 Citations (Scopus)

Incidence of and Risk Factors for Pulmonary Autograft Dilation After Ross Aortic Valve Replacement

Brown, J., Ruzmetov, M., Rodefeld, M., Mahomed, Y. & Turrentine, M., May 2007, In : Annals of Thoracic Surgery. 83, 5, p. 1781-1789 9 p.

Research output: Contribution to journal › Article

Autografts

Aortic Valve

Dilatation

Lung

Incidence

65 Citations (Scopus)

In the adult mesenchymal stem cell population, source gender is a biologically relevant aspect of protective power

Crisostomo, P. R., Markel, T. A., Wang, M., Lahm, T., Lillemoe, K. D. & Meldrum, D. R., Aug 2007, In : Surgery. 142, 2, p. 215-221 7 p.

Research output: Contribution to journal › Article

Adult Stem Cells

Mesenchymal Stromal Cells

Population

Intercellular Signaling Peptides and Proteins

Reperfusion

18 Citations (Scopus)

Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF: The roles of p38, ERK, and JNK MAPK signaling

Markel, T. A., Crisostomo, P. R., Wang, M., Herring, C. M., Lahm, T., Meldrum, K. K., Lillemoe, K. D., Rescorla, F. & Meldrum, D. R., Apr 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 4

Research output: Contribution to journal › Article

Vascular Endothelial Growth Factor A

Interleukin-6

Iron

Epithelial Cells

Deferoxamine

21 Citations (Scopus)

Mechanical cavopulmonary assist for the univentricular Fontan circulation using a novel folding propeller blood pump

Throckmorton, A. L., Ballman, K. K., Myers, C. D., Litwak, K. N., Frankel, S. H. & Rodefeld, M., Nov 2007, In : ASAIO Journal. 53, 6, p. 734-741 8 p.

Research output: Contribution to journal › Article

Propellers

Blood

Pumps

Hydraulics

Hydrodynamics

Mediastinal germ cell tumors.

Kesler, K. & Einhorn, L., May 2007, In : Annals of Thoracic Surgery. 83, 5, p. 1915 1 p.

Research output: Contribution to journal › Article

Mediastinal Neoplasms

Germ Cell and Embryonal Neoplasms

53 Citations (Scopus)

Mesenchymal Stem Cells Attenuate Hypoxic Pulmonary Vasoconstriction by a Paracrine Mechanism

Patel, K. M., Crisostomo, P., Lahm, T., Markel, T., Herring, C., Wang, M., Meldrum, K. K., Lillemoe, K. D. & Meldrum, D. R., Dec 2007, In : Journal of Surgical Research. 143, 2, p. 281-285 5 p.

Research output: Contribution to journal › Article

Vasoconstriction

Mesenchymal Stromal Cells

Lung

Pulmonary Artery

Conditioned Culture Medium

5 Citations (Scopus)

Off-Pump Aortic Valve Bypass Using a Valved Apical-Aortic Conduit

Brown, J. & Gammie, J. S., Jun 2007, In : Operative Techniques in Thoracic and Cardiovascular Surgery. 12, 2, p. 85-94 10 p.

Research output: Contribution to journal › Article

Aortic Valve

17 Citations (Scopus)

Postoperative Outpatient Chest Tube Management: Initial Experience With a New Portable System

Rieger, K., Wroblewski, H. A., Brooks, J. A., Hammoud, Z. T. & Kesler, K., Aug 2007, In : Annals of Thoracic Surgery. 84, 2, p. 630-632 3 p.

Research output: Contribution to journal › Article

Chest Tubes

Outpatients

Air

Drainage

Hospital Costs

5 Citations (Scopus)

Prospective evaluation of serum amiodarone concentrations when administered via a nasogastric tube into the stomach conduit after transthoracic esophagectomy

Tisdale, J. E., Wroblewski, H. A., Hammoud, Z. T., Rieger, K., Young, J. V., Wall, D. S. & Kesler, K., Oct 2007, In : Clinical Therapeutics. 29, 10, p. 2226-2234 9 p.

Research output: Contribution to journal › Article

Esophagectomy

Amiodarone

Stomach

Serum

Lung

60 Citations (Scopus)

Right ventricular outflow tract reconstruction with a polytetrafluoroethylene monocusp valve: A twelve-year experience

Brown, J., Ruzmetov, M., Vijay, P., Rodefeld, M. & Turrentine, M., May 2007, In : Journal of Thoracic and Cardiovascular Surgery. 133, 5, p. 1336-1343 8 p.

Research output: Contribution to journal › Article

Polytetrafluoroethylene

Lung

Reoperation

Pathologic Constriction

Pulmonary Atresia

10 Citations (Scopus)

Right ventricular TNF resistance during endotoxemia: The differential effects on ventricular function

Markel, T. A., Crisostomo, P. R., Wang, M., Herrmann, J. L., Abarbanell, A. M. & Meldrum, D. R., Nov 2007, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 293, 5

Research output: Contribution to journal › Article

Endotoxemia

Ventricular Function

Endotoxins

Heart Ventricles

Receptors, Tumor Necrosis Factor, Type II

4 Citations (Scopus)

Selective protein kinase C inhibition attenuates pulmonary artery cytokine expression without affecting hypoxic pulmonary vasoconstriction

Tsai, B. M., Patel, K., Wang, M., Morrell, E. D., Crisostomo, P. R. & Meldrum, D. R., Jan 2007, In : Shock. 27, 1, p. 36-39 4 p.

Research output: Contribution to journal › Article

Vasoconstriction

Protein Kinase C

Pulmonary Artery

Cytokines

Lung

9 Citations (Scopus)

Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation

Wang, M., Zhang, W., Crisostomo, P., Markel, T., Meldrum, K. K., Fu, X. Y. & Meldrum, D. R., Sep 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 293, 3

Research output: Contribution to journal › Article

Endothelial cells

Sex Characteristics

Endothelial Cells

Inflammation

Chemical activation

76 Citations (Scopus)

STAT3 mediates bone marrow mesenchymal stem cell VEGF production

Wang, M., Zhang, W., Crisostomo, P., Markel, T., Meldrum, K. K., Fu, X. Y. & Meldrum, D. R., Jun 2007, In : Journal of Molecular and Cellular Cardiology. 42, 6, p. 1009-1015 7 p.

Research output: Contribution to journal › Article

Mesenchymal Stromal Cells

Vascular Endothelial Growth Factor A

Bone Marrow

p38 Mitogen-Activated Protein Kinases

Knockout Mice

53 Citations (Scopus)

Stem cell mechanisms and paracrine effects: Potential in cardiac surgery

Crisostomo, P. R., Wang, M., Markel, T. A., Lahm, T., Abarbanell, A. M., Herrmann, J. L. & Meldrum, D. R., Oct 2007, In : Shock. 28, 4, p. 375-383 9 p.

Research output: Contribution to journal › Article

Thoracic Surgery

Stem Cells

Heart Diseases

Cytoprotection

Cell- and Tissue-Based Therapy

23 Citations (Scopus)

Stem Cells Improve Right Ventricular Functional Recovery After Acute Pressure Overload and Ischemia Reperfusion Injury

Wairiuko, G. M., Crisostomo, P. R., Wang, M., Morrell, E. D., Meldrum, K. K., Lillemoe, K. D. & Meldrum, D. R., Aug 2007, In : Journal of Surgical Research. 141, 2, p. 241-246 6 p.

Research output: Contribution to journal › Article

Reperfusion Injury

Stem Cells

Ventricular Pressure

Pressure

Heart Ventricles

16 Citations (Scopus)

Surgical Results of Arterial Switch Operation for Taussig-Bing Anomaly: Is Position of the Great Arteries a Risk Factor?

Rodefeld, M., Ruzmetov, M., Vijay, P., Fiore, A. C., Turrentine, M. & Brown, J., Apr 2007, In : Annals of Thoracic Surgery. 83, 4, p. 1451-1457 7 p.

Research output: Contribution to journal › Article

Double Outlet Right Ventricle

Arteries

Thoracic Aorta

Reoperation

Ventricular Outflow Obstruction

42 Citations (Scopus)

The critical role of vascular endothelial growth factor in pulmonary vascular remodeling after lung injury

Lahm, T., Crisostomo, P. R., Markel, T. A., Wang, M., Lillemoe, K. D. & Meldrum, D. R., Jul 2007, In : Shock. 28, 1, p. 4-14 11 p.

Research output: Contribution to journal › Article

Lung Injury

Vascular Endothelial Growth Factor A

Lung

Endothelial Cells

Emphysema

18 Citations (Scopus)

The Effect of Chronic Exogenous Androgen on Myocardial Function Following Acute Ischemia-Reperfusion in Hosts with Different Baseline Levels of Sex Steroids

Nam, U. H., Wang, M., Crisostomo, P. R., Markel, T. A., Lahm, T., Meldrum, K. K., Lillemoe, K. D. & Meldrum, D. R., Sep 2007, In : Journal of Surgical Research. 142, 1, p. 113-118 6 p.

Research output: Contribution to journal › Article

Androgens

Reperfusion

Testosterone

Ischemia

Dihydrotestosterone

40 Citations (Scopus)

The struggle for iron: Gastrointestinal microbes modulate the host immune response during infection

Markel, T. A., Crisostomo, P. R., Wang, M., Herring, C. M., Meldrum, K. K., Lillemoe, K. D. & Meldrum, D. R., Feb 1 2007, In : Journal of Leukocyte Biology. 81, 2, p. 393-400 8 p.

Research output: Contribution to journal › Article

Iron

Infection

Macrophages

Immune Tolerance

Necrotizing Enterocolitis

118 Citations (Scopus)

Treatment of non-small cell lung cancer, stage IIIB: ACCP evidence-based clinical practice guidelines (2nd edition)

Jett, J. R., Schild, S. E., Keith, R. L. & Kesler, K., Sep 2007, In : Chest. 132, 3 SUPPL.

Research output: Contribution to journal › Article

Evidence-Based Practice

Chemoradiotherapy

Practice Guidelines

Non-Small Cell Lung Carcinoma

Radiotherapy

8 Citations (Scopus)

When Reconstruction Fails or is Not Feasible: Valve Replacement Options in the Pediatric Population

Husain, S. A. & Brown, J., 2007, In : Pediatric Cardiac Surgery Annual. 10, 1, p. 117-124 8 p.

Research output: Contribution to journal › Article

Pediatrics

Population

Anatomy

Pathology

Growth

2006

80 Citations (Scopus)

17-β-Estradiol decreases p38 MAPK-mediated myocardial inflammation and dysfunction following acute ischemia

Wang, M., Tsai, B. M., Reiger, K. M., Brown, J. & Meldrum, D. R., Feb 2006, In : Journal of Molecular and Cellular Cardiology. 40, 2, p. 205-212 8 p.

Research output: Contribution to journal › Article

p38 Mitogen-Activated Protein Kinases

Estradiol

Ischemia

Inflammation

Estrogens

3 Citations (Scopus)

AJR teaching file: Right ventricular mass presenting with a heart murmur

Choplin, R. & Turrentine, M., Dec 2006, In : American Journal of Roentgenology. 187, SUPPL. 6

Research output: Contribution to journal › Article

Heart Murmurs

Choristoma

Heart Neoplasms

Myocarditis

Heart Ventricles

45 Citations (Scopus)

Aortic Valve Bypass for the High-Risk Patient With Aortic Stenosis

Gammie, J. S., Brown, J., Brown, J. M., Poston, R. S., Pierson, R. N., Odonkor, P. N., White, C. S., Gottdiener, J. S. & Griffith, B. P., May 2006, In : Annals of Thoracic Surgery. 81, 5, p. 1605-1610 6 p.

Research output: Contribution to journal › Article

Aortic Valve Stenosis

Aortic Valve

Cardiopulmonary Bypass

Thoracic Aorta

Transplants

74 Citations (Scopus)

A prospective analysis of the incidence and risk factors associated with junctional ectopic tachycardia following surgery for congenital heart disease

Batra, A. S., Chun, D. S., Johnson, T., Maldonado, E. M., Kashyap, B. A., Maiers, J., Lindblade, C. L., Rodefeld, M., Brown, J. & Hubbard, J. E., Feb 2006, In : Pediatric Cardiology. 27, 1, p. 51-55 5 p.

Research output: Contribution to journal › Article

Ectopic Junctional Tachycardia

Heart Diseases

Incidence

Bundle of His

Cardiopulmonary Bypass

Biologic versus Mechanical Valve Replacement of the Pulmonary Valve After Multiple Reconstructions of the RVOT Tract

Husain, S. A. & Brown, J., 2006, In : Operative Techniques in Thoracic and Cardiovascular Surgery. 11, 3, p. 207-215 9 p.

Research output: Contribution to journal › Article

Pulmonary Valve

60 Citations (Scopus)

Can pulmonary conduit dysfunction and failure be reduced in infants and children less than age 2 years at initial implantation?

Karamlou, T., Blackstone, E. H., Hawkins, J. A., Jacobs, M. L., Kanter, K. R., Brown, J., Mavroudis, C., Caldarone, C. A., Williams, W. G. & McCrindle, B. W., Oct 2006, In : Journal of Thoracic and Cardiovascular Surgery. 132, 4

Research output: Contribution to journal › Article

Lung

Allografts

Neck

Pulmonary Valve Insufficiency

Heterografts

51 Citations (Scopus)

Caval division technique for sinus venosus atrial septal defect with partial anomalous pulmonary venous connection

Shahriari, A., Rodefeld, M., Turrentine, M. & Brown, J., Jan 2006, In : Annals of Thoracic Surgery. 81, 1, p. 224-230 7 p.

Research output: Contribution to journal › Article

Venae Cavae

Lung

Superior Vena Cava

Veins

Superior Vena Cava Syndrome

13 Citations (Scopus)

Closed transventricular aortic valvotomy for critical aortic stenosis in neonates: Outcomes, risk factors, and reoperations

Brown, J., Ruzmetov, M., Vijay, P., Rodefeld, M. & Turrentine, M., Jan 2006, In : Annals of Thoracic Surgery. 81, 1, p. 236-242 7 p.

Research output: Contribution to journal › Article

Aortic Valve Stenosis

Reoperation

Newborn Infant

Heart Ventricles

Endocardial Fibroelastosis

9 Citations (Scopus)

Disparate IL-1β and iNOS gene expression in the aorta and pulmonary artery after endotoxemia

Tsai, B. M., Wang, M., Pitcher, J. M., Kher, A. & Meldrum, D. R., Feb 2006, In : Surgical Infections. 7, 1, p. 21-27 7 p.

Research output: Contribution to journal › Article

Endotoxemia

Nitric Oxide Synthase Type II

Interleukin-1

Pulmonary Artery

Aorta

4 Citations (Scopus)

Does endogenous testosterone mediate the lower preconditioning threshold in males?

Nelson, N. T., Mahomed, A. J., Pitcher, J. M., Tsai, B. M., Wang, M., Mahomed, Y., Brown, J., Crisostomo, P. & Meldrum, D. R., Mar 2006, In : Journal of Surgical Research. 131, 1, p. 86-90 5 p.

Research output: Contribution to journal › Article

Testosterone

Wounds and Injuries

Intraperitoneal Injections

Salmonella typhimurium

Sprague Dawley Rats

14 Citations (Scopus)

Endogenous estrogen mediates a higher threshold for endotoxin-induced myocardial protection in females

Pitcher, J. M., Wang, M., Tsai, B. M., Kher, A., Nelson, N. T. & Meldrum, D. R., Jan 2006, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 290, 1

Research output: Contribution to journal › Article

Endotoxins

Estrogens

Proestrus

Wounds and Injuries

p38 Mitogen-Activated Protein Kinases

124 Citations (Scopus)

Estrogen receptor-α mediates acute myocardial protection in females

Wang, M., Crisostomo, P., Wairiuko, G. M. & Meldrum, D. R., Jun 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 290, 6

Research output: Contribution to journal › Article

Estrogen Receptors

Ischemia

Sex Characteristics

Reperfusion

Cytokines

32 Citations (Scopus)

Evolution of aortic valve replacement in children: A single center experience

Ruzmetov, M., Vijay, P., Rodefeld, M., Turrentine, M. & Brown, J., Nov 10 2006, In : International Journal of Cardiology. 113, 2, p. 194-200 7 p.

Research output: Contribution to journal › Article

Aortic Valve

Reoperation

Heterografts

Prostheses and Implants

Aortic Valve Stenosis

26 Citations (Scopus)

Fate of the autograft and homograft following ross aortic valve replacement: Reoperative frequency, outcome, and management

Brown, J., Ruzmetov, M., Fukui, T., Rodefeld, M., Mahomed, Y. & Turrentine, M., Mar 2006, In : Journal of Heart Valve Disease. 15, 2, p. 253-260 8 p.

Research output: Contribution to journal › Article

Autografts

Aortic Valve

Allografts

Lung

Pediatrics

121 Citations (Scopus)

High passage number of stem cells adversely affects stem cell activation and myocardial protection

Crisostomo, P. R., Wang, M., Wairiuko, G. M., Morrell, E. D., Terrell, A. M., Seshadri, P., Nam, U. H. & Meldrum, D. R., Dec 2006, In : Shock. 26, 6, p. 575-580 6 p.

Research output: Contribution to journal › Article

Mesenchymal Stromal Cells

Stem Cells

Ischemia

Vascular Endothelial Growth Factor A

Lipopolysaccharides

219 Citations (Scopus)

Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF, and IGF-I in response to TNF by a p38 MAPK-dependent mechanism

Wang, M., Crisostomo, P. R., Herring, C., Meldrum, K. K. & Meldrum, D. R., 2006, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 291, 4

Research output: Contribution to journal › Article

Hepatocyte Growth Factor

p38 Mitogen-Activated Protein Kinases

Insulin-Like Growth Factor I

Vascular Endothelial Growth Factor A

Adipose Tissue

70 Citations (Scopus)

JAK/STAT/SOCS signaling circuits and associated cytokine-mediated inflammation and hypertrophy in the heart

Terrell, A. M., Crisostomo, P. R., Wairiuko, G. M., Wang, M., Morrell, E. D. & Meldrum, D. R., Sep 2006, In : Shock. 26, 3, p. 226-234 9 p.

Research output: Contribution to journal › Article

Suppressor of Cytokine Signaling Proteins

Janus Kinases

Cardiomegaly

Transducers

Cytokines