Pediatric Hematology/Oncology

Publications

2020

A Metabolomics Approach for Early Prediction of Vincristine-Induced Peripheral Neuropathy

Verma, P., Devaraj, J., Skiles, J. L., Sajdyk, T., Ho, R. H., Hutchinson, R., Wells, E., Li, L., Renbarger, J., Cooper, B. & Ramkrishna, D., Jun 15 2020, In : Scientific reports. 10, 1, p. 9659 1 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway (Nature Communications, (2019), 10, 1, (5649), 10.1038/s41467-019-13542-2)

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2020, In : Nature communications. 11, 1, 3856.

Research output: Contribution to journalComment/debate

Open Access

Bcl6 and Blimp1 reciprocally regulate ST2+ Treg–cell development in the context of allergic airway inflammation

Koh, B., Ulrich, B. J., Nelson, A. S., Panangipalli, G., Kharwadkar, R., Wu, W., Xie, M. M., Fu, Y., Turner, M. J., Paczesny, S., Janga, S. C., Dent, A. L. & Kaplan, M. H., 2020, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Open Access

Biomarkers for Allogeneic HCT Outcomes

Adom, D., Rowan, C., Adeniyan, T., Yang, J. & Paczesny, S., Apr 21 2020, In : Frontiers in immunology. 11, 673.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

David A. Boothman, 1958-2019

Criswell, T. L. & Mayo, L. D., Mar 1 2020, In : Radiation research. 193, 3, p. 301-303 3 p.

Research output: Contribution to journalArticle

Early administration of imatinib mesylate reduces plexiform neurofibroma tumor burden with durable results after drug discontinuation in a mouse model of neurofibromatosis type 1

Armstrong, A. E., Rhodes, S. D., Smith, A., Chen, S., Bessler, W., Ferguson, M. J., Jiang, L., Li, X., Yuan, J., Yang, X., Yang, F. C., Robertson, K. A., Ingram, D. A., Blakeley, J. O. & Clapp, D. W., Aug 1 2020, In : Pediatric Blood and Cancer. 67, 8, e28372.

Research output: Contribution to journalArticle

Early high plasma ST2, the decoy IL-33 receptor, in children undergoing hematopoietic cell transplantation is associated with the development of post-transplant diabetes mellitus

Rowan, C. M., Teagarden, A. M., Cater, D. T., Moser, E. A. S., Baykoyannis, G. & Paczesny, S., May 1 2020, In : Haematologica. 105, 5, p. E249-E252

Research output: Contribution to journalLetter

Open Access
2 Scopus citations

Ex vivo culture of mouse skin activates an interleukin 1 alpha-dependent inflammatory response

Zhou, H. M., Slominski, R. M., Seymour, L. J., Bell, M. C., Dave, P., Atumonye, J., Wright, W., Dawes, A., Griesenauer, B., Paczesny, S., Kaplan, M. H., Spandau, D. F. & Turner, M. J., Jan 1 2020, In : Experimental Dermatology. 29, 1, p. 102-106 5 p.

Research output: Contribution to journalArticle

GVHD risk assessment beyond current HLA evaluation

Paczesny, S., Jan 2020, In : The Lancet Haematology. 7, 1, p. e8-e9

Research output: Contribution to journalComment/debate

HLA-B leads survival after HCT

Paczesny, S., Jul 16 2020, In : Blood. 136, 3, p. 267-268 2 p.

Research output: Contribution to journalArticle

How old is too old? In vivo engraftment of human peripheral bloodstem cells cryopreserved for up to 18 years - implications for clinical transplantation and stability programs

Underwood, J., Rahim, M., West, C., Britton, R., Skipworth, E., Graves, V., Sexton, S., Harris, H., Schwering, D., Sinn, A., Pollok, K. E., Robertson, K. A., Goebel, W. S. & Hege, K. M., May 26 2020, In : World Journal of Stem Cells. 12, 5, p. 359-367 9 p.

Research output: Contribution to journalArticle

Open Access

Influence of health insurance status on childhood cancer treatment outcomes in Kenya

Olbara, G., Martijn, H. A., Njuguna, F., Langat, S., Martin, S., Skiles, J., Vik, T., Kaspers, G. J. L. & Mostert, S., Feb 1 2020, In : Supportive Care in Cancer. 28, 2, p. 917-924 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Investigation of donor KIR content and matching in children undergoing hematopoietic cell transplantation for acute leukemia

Verneris, M. R., Miller, J. S., Hsu, K. C., Wang, T., Sees, J. A., Paczesny, S., Rangarajan, H., Lee, D. A., Spellman, S. R. & Lee, S. J., Apr 14 2020, In : Blood Advances. 4, 7, p. 1350-1356 7 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy

Principe, D. R., Narbutis, M., Kumar, S., Park, A., Viswakarma, N., Dorman, M. J., Kamath, S. D., Grippo, P. J., Fishel, M. L., Hwang, R. F., Thummuri, D., Underwood, P. W., Munshi, H. G., Trevino, J. G. & Rana, A., Aug 1 2020, In : Cancer Research. 80, 15, p. 3101-3115 15 p.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Mdm2-mediated neddylation of pVHL blocks the induction of antiangiogenic factors

Wolf, E. R., Mabry, A. R., Damania, B. & Mayo, L. D., Jul 16 2020, In : Oncogene. 39, 29, p. 5228-5239 12 p.

Research output: Contribution to journalArticle

Megakaryocytes Enhance Mesenchymal Stromal Cells Proliferation and Inhibit Differentiation

Emmakah, A. M., Arman, H. E., Alvarez, M. B., Childress, P. J., Bidwell, J. P., Goebel, W. S., Gabriel Chu, T. M. & Kacena, M., 2020, In : Journal of Cellular Biochemistry.

Research output: Contribution to journalArticle

Phenotypic Screening of Chemical Libraries Enriched by Molecular Docking to Multiple Targets Selected from Glioblastoma Genomic Data

Xu, D., Zhou, D., Bum-Erdene, K., Bailey, B. J., Sishtla, K., Liu, S., Wan, J., Aryal, U. K., Lee, J. A., Wells, C. D., Fishel, M. L., Corson, T. W., Pollok, K. E. & Meroueh, S. O., Jun 19 2020, In : ACS chemical biology. 15, 6, p. 1424-1444 21 p.

Research output: Contribution to journalArticle

Post-haematopoietic cell transplantation outcomes: why ST2 became a ‘golden nugget’ biomarker

Paczesny, S., Jan 1 2020, (Accepted/In press) In : British journal of haematology.

Research output: Contribution to journalReview article

ST2 as checkpoint target for colorectal cancer immunotherapy

Van Der Jeught, K., Sun, Y., Fang, Y., Zhou, Z., Jiang, H., Yu, T., Yang, J., Kamocka, M. M., So, K. M., Li, Y., Eyvani, H., Sandusky, G. E., Frieden, M., Braun, H., Beyaert, R., He, X., Zhang, X., Zhang, C., Paczesny, S. & Lu, X., May 7 2020, In : JCI Insight. 5, 9, e136073.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Successful Allogeneic Stem Cell Transplant in Pediatric Patients with Diminished Left Ventricular Ejection Fractions

Lyon, S. M., Schamberger, M. S., Delgado, D. C., Skiles, J. L., Goebel, W. S., Robertson, K. A. & Parent, J. J., Jan 1 2020, (Accepted/In press) In : Journal of Pediatric Hematology/Oncology. 1792.

Research output: Contribution to journalArticle

The IL-33 Receptor/ST2 acts as a positive regulator of functional mouse bone marrow hematopoietic stem and progenitor cells

Capitano, M. L., Griesenauer, B., Guo, B., Cooper, S., Paczesny, S. & Broxmeyer, H. E., Sep 2020, In : Blood Cells, Molecules, and Diseases. 84, 102435.

Research output: Contribution to journalArticle

3 Scopus citations
2019

Antitumor activity and mechanistic characterization of APE1/ReF-1 inhibitors in bladder cancer

Fishel, M. L., Xia, H., McGeown, J., McIlwain, D. W., Elbanna, M., Craft, A. A., Kaimakliotis, H. Z., Sandusky, G. E., Zhang, C., Pili, R., Kelley, M. R. & Jerde, T. J., 2019, In : Molecular cancer therapeutics. 18, 11, p. 1947-1960 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

A proteasome-resistant fragment of NIK mediates oncogenic NF-κ B signaling in schwannomas

Gehlhausen, J. R., Hawley, E., Wahle, B. M., He, Y., Edwards, D., Rhodes, S. D., Lajiness, J. D., Staser, K., Chen, S., Yang, X., Yuan, J., Li, X., Jiang, L., Smith, A., Bessler, W., Sandusky, G., Stemmer-Rachamimov, A., Stuhlmiller, T. J., Angus, S. P., Johnson, G. L. & 4 others, Nalepa, G., Yates, C. W., Wade Clapp, D. & Park, S. J., 2019, In : Human molecular genetics. 28, 4, p. 572-583 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Biomarkers for Early Complications After Hematopoietic Stem Cell Transplantation

Rowan, C. M. & Paczesny, S., Mar 2019, In : Clinics in Laboratory Medicine. 39, 1, p. 61-72 12 p.

Research output: Contribution to journalReview article

4 Scopus citations

Bodyweight-adjusted rivaroxaban for children with venous thromboembolism (EINSTEIN-Jr): results from three multicentre, single-arm, phase 2 studies

EINSTEIN-Jr Phase 2 Investigators, Oct 2019, In : The Lancet Haematology. 6, 10, p. e500-e509

Research output: Contribution to journalArticle

11 Scopus citations

Clinical Proteomics for Post-Hematopoeitic Stem Cell Transplantation Outcomes

Paczesny, S. & Metzger, J., Mar 2019, In : Proteomics - Clinical Applications. 13, 2, 1800145.

Research output: Contribution to journalReview article

3 Scopus citations

Comparison of multi-shot and single shot echo-planar diffusion tensor techniques for the optic pathway in patients with neurofibromatosis type 1

Ho, C. Y., Deardorff, R., Kralik, S. F., West, J. D., Wu, Y. C. & Shih, C. S., Apr 12 2019, In : Neuroradiology. 61, 4, p. 431-441 11 p.

Research output: Contribution to journalArticle

Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1

Trilles, R., Beglov, D., Chen, Q., He, H., Wireman, R., Reed, A., Chennamadhavuni, S., Panek, J. S., Brown, L. E., Vajda, S., Porco, J. A., Kelley, M. R. & Georgiadis, M. M., Feb 28 2019, In : Journal of Medicinal Chemistry. 62, 4, p. 1971-1988 18 p.

Research output: Contribution to journalArticle

1 Scopus citations

Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas

Wan, J., Dai, H., Zhang, X., Liu, S., Lin, Y., Somani, A. K., Xie, J. & Han, J., Jan 1 2019, (Accepted/In press) In : Genes and Diseases.

Research output: Contribution to journalArticle

Open Access

Donor HLA-E Status Associates with Disease-Free Survival and Transplant-Related Mortality after Non In Vivo T Cell-Depleted HSCT for Acute Leukemia

Tsamadou, C., Fürst, D., Wang, T., He, N., Lee, S. J., Spellman, S. R., Fleischhauer, K., Hsu, K. C., Paczesny, S., Verneris, M. R., Schrezenmeier, H. & Mytilineos, J., 2019, (Accepted/In press) In : Biology of Blood and Marrow Transplantation.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Endocrine and Metabolic Disorders in Survivors of Childhood Cancers and Health-Related Quality of Life and Physical Activity

Pradhan, K. R., Chen, Y., Moustoufi-Moab, S., Krull, K., Oeffinger, K. C., Sklar, C., Armstrong, G. T., Ness, K. K., Robison, L., Yasui, Y. & Nathan, P. C., Nov 1 2019, In : The Journal of clinical endocrinology and metabolism. 104, 11, p. 5183-5194 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination

Frossi, B., Antoniali, G., Yu, K., Akhtar, N., Kaplan, M. H., Kelley, M. R., Tell, G. & Pucillo, C. E. M., Mar 29 2019, In : Journal of Biological Chemistry. 294, 13, p. 5198-5207 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Evidence for BCR/ABL1-positive T-cell acute lymphoblastic leukemia arising in an early lymphoid progenitor cell

Ragg, S., Zehentner, B. K., Loken, M. R. & Croop, J. M., Sep 2019, In : Pediatric Blood and Cancer. 66, 9, e27829.

Research output: Contribution to journalArticle

Gene co-expression networks restructured gene fusion in rhabdomyosarcoma cancers

Helm, B. R., Zhan, X., Pandya, P. H., Murray, M. E., Pollok, K. E., Renbarger, J. L., Ferguson, M. J., Han, Z., Ni, D., Zhang, J. & Huang, K., Sep 2019, In : Genes. 10, 9, 665.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Genetic Variants Associated With Vincristine-Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia

Li, L., Sajdyk, T., Smith, E. M. L., Chang, C. W., Li, C., Ho, R. H., Hutchinson, R., Wells, E., Skiles, J. L., Winick, N., Martin, P. L. & Renbarger, J. L., Jun 2019, In : Clinical Pharmacology and Therapeutics. 105, 6, p. 1421-1428 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Graft-versus-host disease–free antitumoral signature after allogeneic donor lymphocyte injection identified by proteomics and systems biology

Liu, X., Yue, Z., Cao, Y., Taylor, L., Zhang, Q., Choi, S. W., Hanash, S., Ito, S., Chen, J. Y., Wu, H. & Paczesny, S., 2019, In : JCO Precision Oncology. 3

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer

Shouksmith, A. E., Shah, F., Grimard, M. L., Gawel, J. M., Raouf, Y. S., Geletu, M., Berger-Becvar, A., De Araujo, E. D., Luchman, H. A., Heaton, W. L., Bakhshinyan, D., Adile, A. A., Venugopal, C., O'Hare, T., Deininger, M. W., Singh, S. K., Konieczny, S. F., Weiss, S., Fishel, M. L. & Gunning, P. T., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2651-2665 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Immune Reconstitution and Infection Patterns after Early Alemtuzumab and Reduced Intensity Transplantation for Nonmalignant Disorders in Pediatric Patients

Bhatt, S. T., Bednarski, J. J., Berg, J., Trinkaus, K., Murray, L., Hayashi, R., Schulz, G., Hente, M., Grimley, M., Chan, K. W., Kamani, N., Jacobsohn, D., Nieder, M., Hale, G., Yu, L., Adams, R., Dalal, J., Pulsipher, M. A., Haut, P., Chaudhury, S. & 5 others, Davis, J., Jaroscak, J., Andreansky, M., Willert, J. & Shenoy, S., Mar 2019, In : Biology of Blood and Marrow Transplantation. 25, 3, p. 556-561 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Impact of socioeconomic markers on parents' retention of pediatric oncology home care education: A pilot study

Hentea, C., Downs, S. M., Tucker Edmonds, B., Vik, T., Wiehe, S. E. & Cheng, E. R., Jan 1 2019, In : Pediatric Blood and Cancer. e27624.

Research output: Contribution to journalArticle

1 Scopus citations

Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway

Codrich, M., Comelli, M., Malfatti, M. C., Mio, C., Ayyildiz, D., Zhang, C., Kelley, M. R., Terrosu, G., Pucillo, C. E. M. & Tell, G., Oct 2019, In : DNA Repair. 82, 102675.

Research output: Contribution to journalArticle

4 Scopus citations

Integration of genomic copy number variations and chemotherapy-response biomarkers in pediatric sarcoma

Cheng, L., Pandya, P. H., Liu, E., Chandra, P., Wang, L., Murray, M. E., Carter, J., Ferguson, M., Saadatzadeh, M. R., Bijangi-Visheshsaraei, K., Marshall, M., Li, L., Pollok, K. E. & Renbarger, J. L., Jan 31 2019, In : BMC Medical Genomics. 12, 23.

Research output: Contribution to journalArticle

10 Scopus citations

LTMG: a novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data

Wan, C., Chang, W., Zhang, Y., Shah, F., Lu, X., Zang, Y., Zhang, A., Cao, S., Fishel, M. L., Ma, Q. & Zhang, C., Oct 10 2019, In : Nucleic acids research. 47, 18, p. e111

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Multiple functional variants in the IL1RL1 region are pretransplant markers for risk of GVHD and infection deaths

Karaesmen, E., Hahn, T., Dile, A. J., Rizvi, A. A., Wang, J., Wang, T., Haagenson, M. D., Preus, L., Zhu, Q., Liu, Q., Yan, L., Liu, S., Haiman, C. A., Stram, D., Pooler, L., Sheng, X., Van Den Berg, D., Brock, G., Webb, A., McCarthy, P. L. & 5 others, Pasquini, M. C., Spellman, S. R., Lee, S. J., Paczesny, S. & Sucheston-Campbell, L. E., Aug 27 2019, In : Blood Advances. 3, 16, p. 2512-2524 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2019, In : Nature communications. 10, 1, 5649.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development

Nabinger, S. C., Chen, S., Gao, R., Yao, C., Kobayashi, M., Vemula, S., Fahey, A. C., Wang, C., Daniels, C., Boswell, H. S., Sandusky, G. E., Mayo, L. D., Kapur, R. & Liu, Y., Jun 1 2019, In : Leukemia. 33, 6, p. 1535-1539 5 p.

Research output: Contribution to journalLetter

5 Scopus citations

Rorc restrains the potency of ST2+ regulatory T cells in ameliorating intestinal graft-versus-host disease

Yang, J., Ramadan, A., Reichenbach, D. K., Loschi, M., Zhang, J., Griesenauer, B., Liu, H., Hippen, K. L., Blazar, B. R. & Paczesny, S., Mar 7 2019, In : JCI Insight. 4, 5

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction

Bum-Erdene, K., Zhou, D., Gonzalez-Gutierrez, G., Ghozayel, M. K., Si, Y., Xu, D., Shannon, H. E., Bailey, B. J., Corson, T. W., Pollok, K. E., Wells, C. D. & Meroueh, S. O., Mar 21 2019, In : Cell Chemical Biology. 26, 3, p. 378-389.e13

Research output: Contribution to journalArticle

19 Scopus citations

ST2/MyD88 deficiency protects mice against acute graft-versus-host disease and spares regulatory T cells

Griesenauer, B., Jiang, H., Yang, J., Zhang, J., Ramadan, A. M., Egbosiuba, J., Campa, K. & Paczesny, S., May 15 2019, In : Journal of Immunology. 202, 10, p. 3053-3064 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Sustained complete response to palbociclib in a refractory pediatric sarcoma with BCOR-CCNB3 fusion and germline CDKN2B variant

Tramontana, T. F., Marshall, M. S., Helvie, A. E., Schmitt, M. R., Ivanovich, J., Carter, J. L., Renbarger, J. L. & Ferguson, M. J., 2019, In : JCO Precision Oncology. 3, p. 466-471 6 p.

Research output: Contribution to journalArticle

Open Access

The effect of molecular weight on passage of proteins through the blood-aqueous barrier

Ragg, S., Key, M., Rankin, F. & WuDunn, D., Apr 2019, In : Investigative Ophthalmology and Visual Science. 60, 5, p. 1461-1469 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations