Pediatric Infectious Disease

Publications

2020

Associations of childhood exposure to malaria with cognition and behavior outcomes: A systematic review protocol

Ssemata, A. S., Nakitende, J. A., Kizito, S., Whipple, E. C., Bangirana, P., Nakasujja, N., John, C. C. & McHenry, M. S., Aug 9 2020, In : Systematic Reviews. 9, 1, 174.

Research output: Contribution to journalReview article

Open Access

Blackwater Fever in Ugandan Children With Severe Anemia is Associated With Poor Postdischarge Outcomes: A Prospective Cohort Study

Opoka, R. O., Waiswa, A., Harriet, N., John, C. C., Tumwine, J. K. & Karamagi, C., May 23 2020, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 70, 11, p. 2247-2254 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Caring for the child traveler: Results of a practice gaps and educational needs survey

Molitor-Kirsch, S. A., Leshem, E., Fischer, P. R., Christenson, J. C., Kohl, S., Mackell, S., Starr, M. & Hagmann, S. H. F., 2020, (Accepted/In press) In : Travel Medicine and Infectious Disease. 101763.

Research output: Contribution to journalLetter

Central nervous system virus infection in African children with cerebral malaria

Postels, D. G., Osei-Tutu, L., Seydel, K. B., Xu, Q., Li, C., Taylor, T. E., John, C. C., Mallewa, M., Solomon, T., Agbenyega, T., Ansong, D., Opoka, R. O., Khan, L. M., Ramachandran, P. S., Leon, K. E., DeRisi, J. L., Langelier, C. & Wilson, M. R., Jul 2020, In : American Journal of Tropical Medicine and Hygiene. 103, 1, p. 200-205 6 p.

Research output: Contribution to journalArticle

Comparison of Risk of Recrudescent Fever in Children With Kawasaki Disease Treated With Intravenous Immunoglobulin and Low-Dose vs High-Dose Aspirin

Platt, B., Belarski, E., Manaloor, J., Ofner, S., Carroll, A. E., John, C. C. & Wood, J. B., Jan 3 2020, In : JAMA Network Open. 3, 1, p. e1918565

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

COVID-19: Shining the light on Africa

Rosenthal, P. J., Breman, J. G., Djimde, A. A., John, C. C., Kamya, M. R., Leke, R. G. F., Moeti, M. R., Nkengasong, J. & Bausch, D. G., Jun 2020, In : American Journal of Tropical Medicine and Hygiene. 102, 6, p. 1145-1148 4 p.

Research output: Contribution to journalEditorial

Open Access
1 Scopus citations

Delayed iron does not alter cognition or behavior among children with severe malaria and iron deficiency

Ssemata, A. S., Hickson, M., Ssenkusu, J. M., Cusick, S. E., Nakasujja, N., Opoka, R. O., Kroupina, M., Georgieff, M. K., Bangirana, P. & John, C. C., Sep 1 2020, In : Pediatric Research. 88, 3, p. 429-437 9 p.

Research output: Contribution to journalArticle

Delayed iron improves iron status without altering malaria risk in severe malarial anemia

Cusick, S. E., Opoka, R. O., Ssemata, A. S., Georgieff, M. K., John, C. C. & John, C. C., May 1 2020, In : American Journal of Clinical Nutrition. 111, 5, p. 1059-1067 9 p.

Research output: Contribution to journalArticle

Open Access

Endothelial Activation, Acute Kidney Injury, and Cognitive Impairment in Pediatric Severe Malaria

Ouma, B. J., Ssenkusu, J. M., Shabani, E., Datta, D., Opoka, R. O., Idro, R., Bangirana, P., Park, G., Joloba, M. L., Kain, K. C., John, C. C. & Conroy, A. L., Sep 1 2020, In : Critical care medicine. 48, 9, p. e734-e743

Research output: Contribution to journalArticle

Global Pediatric Research Investigator: Andrew Ssemata

Ssemata, A. & John, C., Sep 1 2020, In : Pediatric Research. 88, 3, p. 356 1 p.

Research output: Contribution to journalComment/debate

Open Access

Hydroxyurea dose escalation for sickle cell Anemia in sub-Saharan Africa

John, C. C., Opoka, R. O., Latham, T. S., Hume, H. A., Nabaggala, C., Kasirye, P., Ndugwa, C. M., Lane, A. & Ware, R. E., Jun 25 2020, In : New England Journal of Medicine. 382, 26, p. 2524-2533 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Hydroxyurea to lower transcranial Doppler velocities and prevent primary stroke: The Uganda NOHARM sickle cell anemia cohort

Opoka, R. O., Hume, H. A., Latham, T. S., Lane, A., Williams, O., Tymon, J., Nakafeero, M., Kasirye, P., Ndugwa, C. M., John, C. C. & Ware, R. E., Jun 1 2020, In : Haematologica. 105, 6, p. E272-E275

Research output: Contribution to journalLetter

Open Access
1 Scopus citations

Malaria parasitemia among blood donors in Uganda

Murphy, K. J., Conroy, A. L., Ddungu, H., Shrestha, R., Kyeyune-Byabazaire, D., Petersen, M. R., Musisi, E., Patel, E. U., Kasirye, R., Bloch, E. M., Lubega, I., John, C. C., Hume, H. A. & Tobian, A. A. R., May 1 2020, In : Transfusion. 60, 5, p. 955-964 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Perceived benefits and risks of participation in a clinical trial for Ugandan children with sickle cell anemia

Carman, A. S., Sautter, C., Anyanwu, J. N., Ssemata, A. S., Opoka, R. O., Ware, R. E., Rujumba, J. & John, C. C., Feb 1 2020, In : Pediatric Blood and Cancer. 67, 2, e27830.

Research output: Contribution to journalArticle

1 Scopus citations

Something small that matters

John, C. C., 2020, In : American Journal of Tropical Medicine and Hygiene. 102, 2, p. 253-256 4 p.

Research output: Contribution to journalEditorial

Open Access
2019

Acute kidney injury in Ugandan children with severe malaria is associated with long-term behavioral problems

Hickson, M. R., Conroy, A. L., Bangirana, P., Opoka, R. O., Idro, R., Ssenkusu, J. M. & John, C. C., Dec 2019, In : PloS one. 14, 12, e0226405.

Research output: Contribution to journalArticle

Open Access

Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria

Conroy, A. L., Opoka, R. O., Bangirana, P., Idro, R., Ssenkusu, J. M., Datta, D., Hodges, J. S., Morgan, C. & John, C. C., May 21 2019, In : BMC medicine. 17, 1, 98.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Adherence to clinical guidelines is associated with reduced inpatient mortality among children with severe anemia in Ugandan hospitals

Opoka, R. O., Ssemata, A. S., Oyang, W., Nambuya, H., John, C. C., Karamagi, C. & Tumwine, J. K., Jan 2019, In : PloS one. 14, 1, e0210982.

Research output: Contribution to journalArticle

3 Scopus citations

Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria

Rivera-Correa, J., Conroy, A. L., Opoka, R. O., Batte, A., Namazzi, R., Ouma, B., Bangirana, P., Idro, R., Schwaderer, A. L., John, C. C. & Rodriguez, A., Dec 1 2019, In : Scientific reports. 9, 1, 14940.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Blood use in sub-Saharan Africa: a systematic review of current data

Dhabangi, A., Dzik, W. H., Idro, R., John, C. C., Butler, E. K., Spijker, R. & van Hensbroek, M. B., Jul 2019, In : Transfusion. 59, 7, p. 2446-2454 9 p.

Research output: Contribution to journalReview article

Caregivers and community perceptions of blood transfusion for children with severe anaemia in Uganda

Dhabangi, A., Idro, R., John, C. C., Dzik, W. H., Opoka, R., Siu, G. E., Ayebare, F. & van Hensbroek, M. B., Feb 1 2019, In : Transfusion Medicine. 29, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

Case report: Birth outcome and neurodevelopment in placental malaria discordant twins

Conroy, A. L., Bangirana, P., Muhindo, M. K., Kakuru, A., Jagannathan, P., Opoka, R. O., Liechty, E., Nakalembe, M., Kamya, M. R., Dorsey, G. & John, C. C., Jan 1 2019, In : American Journal of Tropical Medicine and Hygiene. 100, 3, p. 552-555 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Community perceptions of paediatric severe anaemia in Uganda

Dhabangi, A., Idro, R., John, C., Dzik, W. H., Siu, G. E., Opoka, R. O., Ayebare, F. & Van Hensbroek, M. B., Jan 1 2019, In : PLoS One. 14, 1, e0209476.

Research output: Contribution to journalArticle

Comparison of non-magnetic and magnetic beads multiplex assay for assessment of Plasmodium falciparum antibodies

Ondigo, B. N., Park, G. S., Ayieko, C., Nyangahu, D. D., Wasswa, R. & John, C. C., 2019, In : PeerJ. 2019, 1, e6120.

Research output: Contribution to journalArticle

HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya

Odhiambo, E. O., Datta, D., Guyah, B., Ayodo, G., Ondigo, B. N., Abong'O, B. O., John, C. C. & Frosch, A. E. P., Aug 30 2019, In : Malaria Journal. 18, 1, 297.

Research output: Contribution to journalArticle

Open Access

Patterns of traumatic brain injury and six-month neuropsychological outcomes in Uganda

Bangirana, P., Giordani, B., Kobusingye, O., Murungyi, L., Mock, C., John, C. C. & Idro, R., Feb 4 2019, In : BMC Neurology. 19, 1, 18.

Research output: Contribution to journalArticle

2 Scopus citations

Perspective piece malaria: How are we doing and how can we do better?

Rosenthal, P. J., John, C. C. & Regina Rabinovich, N., Jan 1 2019, In : American Journal of Tropical Medicine and Hygiene. 100, 2, p. 239-241 3 p.

Research output: Contribution to journalReview article

4 Scopus citations

Q and A with outgoing ASTMH President Chandy John

John, C. C., 2019, In : American Journal of Tropical Medicine and Hygiene. 101, 6, p. 1202-1203 2 p.

Research output: Contribution to journalComment/debate

Open Access

Risk factors for recurrent severe anemia among previously transfused children in Uganda: An age-matched case-control study

Dhabangi, A., Idro, R., John, C. C., Dzik, W. H., Opoka, R., Ssenyonga, R. & Van Hensbroek, M. B., Jan 18 2019, In : BMC Pediatrics. 19, 1, 27.

Research output: Contribution to journalArticle

What causes severe malaria and its complications in children? Lessons learned over the past

Conroy, A. L., Datta, D. & John, C. C., Mar 7 2019, In : BMC medicine. 17, 1, 52.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Whole-blood transcriptional signatures composed of erythropoietic and NRF2-Regulated genes differ between cerebral malaria and severe malarial anemia

Nallandhighal, S., Park, G. S., Ho, Y. Y., Opoka, R. O., John, C. C. & Tran, T. M., Jan 1 2019, In : Journal of Infectious Diseases. 219, 1, p. 154-164 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Zinc for infection prevention in sickle cell anemia (zips): Study protocol for a randomized placebo-controlled trial in ugandan children with sickle cell anemia

Datta, D., Namazzi, R., Conroy, A. L., Cusick, S. E., Hume, H. A., Tagoola, A., Ware, R. E., Opoka, R. O. & John, C. C., Jul 26 2019, In : Trials. 20, 1, 460.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes

Postels, D. G., Wu, X., Li, C., Kaplan, P. W., Seydel, K. B., Taylor, T. E., Kousa, Y. A., Idro, R., Opoka, R., John, C. C. & Birbeck, G. L., May 22 2018, In : Malaria Journal. 17, 1, 208.

Research output: Contribution to journalArticle

5 Scopus citations

Agents of Eumycotic Mycetoma: Pseudallescheria boydii (Anamorph Scedosporium apiospermum)

Cox, E. G. & Manaloor, J., Jan 1 2018, Principles and Practice of Pediatric Infectious Diseases. Elsevier Inc., p. 1287-1291.e2

Research output: Chapter in Book/Report/Conference proceedingChapter

Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria NCT01255215 NCT

Conroy, A. L., Hawkes, M. T., Elphinstone, R., Opoka, R. O., Namasopo, S., Miller, C., John, C. C. & Kain, K. C., Feb 15 2018, In : Malaria Journal. 17, 1, 82.

Research output: Contribution to journalArticle

4 Scopus citations

High rate of inappropriate blood transfusions in the management of children with severe anemia in Ugandan hospitals

Opoka, R. O., Ssemata, A. S., Oyang, W., Nambuya, H., John, C. C., Tumwine, J. K. & Karamagi, C., Jul 18 2018, In : BMC Health Services Research. 18, 1, 566.

Research output: Contribution to journalArticle

4 Scopus citations

Histoplasma capsulatum (Histoplasmosis)

Christenson, J. C. & Kleiman, M. B., Jan 1 2018, Principles and Practice of Pediatric Infectious Diseases. Elsevier Inc., p. 1259-1266.e2

Research output: Chapter in Book/Report/Conference proceedingChapter

Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial

Bangirana, P., Conroy, A. L., Opoka, R. O., Hawkes, M. T., Hermann, L., Miller, C., Namasopo, S., Liles, W. C., John, C. C. & Kain, K. C., Jan 2018, In : PloS one. 13, 1, e0191550.

Research output: Contribution to journalArticle

7 Scopus citations

Laboratory Diagnosis of Infection Due to Bacteria, Fungi, Parasites, and Rickettsiae

Christenson, J. C., Korgenski, E. K. & Relich, R. F., Jan 1 2018, Principles and Practice of Pediatric Infectious Diseases. Elsevier Inc., p. 1422-1434.e3

Research output: Chapter in Book/Report/Conference proceedingChapter

Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia

Opoka, R. O., Bangirana, P., Idro, R., Shabani, E., Namazzi, R. & John, C. C., Jan 2018, In : Pediatric Blood and Cancer. 65, 1, e26745.

Research output: Contribution to journalArticle

3 Scopus citations

Malaria

Bhumbra, S. S. & John, C., Jan 1 2018, The 5-Minute Pediatric Consult, 8th Edition. Wolters Kluwer Health, p. 568-569 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less than 5 years in Uganda and Kenya: Study protocol for a multi-centre, two-arm, randomised, placebo-controlled, superiority trial

Kwambai, T. K., Dhabangi, A., Idro, R., Opoka, R., Kariuki, S., Samuels, A. M., Desai, M., Van Hensbroek, M. B., John, C. C., Robberstad, B., Wang, D., Phiri, K. & Ter Kuile, F. O., Nov 6 2018, In : Trials. 19, 1, 610.

Research output: Contribution to journalArticle

4 Scopus citations

Sharing antimicrobial reports for pediatric stewardship (SHARPS): A quality improvement collaborative

SHARPS Collaborative, 2018, In : Journal of the Pediatric Infectious Diseases Society. 7, 2, p. 124-128 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa

Taylor, W. R., Naw, H. K., Maitland, K., Williams, T. N., Kapulu, M., D'Alessandro, U., Berkley, J. A., Bejon, P., Okebe, J., Achan, J., Amambua, A. N., Affara, M., Nwakanma, D., van Geertruyden, J. P., Mavoko, M., Lutumba, P., Matangila, J., Brasseur, P., Piola, P., Randremanana, R. & 24 others, Lasry, E., Fanello, C., Onyamboko, M., Schramm, B., Yah, Z., Jones, J., Fairhurst, R. M., Diakite, M., Malenga, G., Molyneux, M., Rwagacondo, C., Obonyo, C., Gadisa, E., Aseffa, A., Loolpapit, M., Henry, M. C., Dorsey, G., John, C., Sirima, S. B., Barnes, K. I., Kremsner, P., Day, N. P., White, N. J. & Mukaka, M., Jan 18 2018, In : BMC medicine. 16, 1, 11.

Research output: Contribution to journalArticle

1 Scopus citations

The art of constructive worrying

John, C. C., Jun 12 2018, In : JAMA - Journal of the American Medical Association. 319, 22, p. 2273-2274 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Travelers' diarrhea in children: A blind spot in the expert panel guidelines on prevention and treatment

on behalf of the Pediatric Interest Group, International Society of Travel Medicine, Feb 1 2018, In : Journal of Travel Medicine. 25, 1, tax075.

Research output: Contribution to journalLetter

4 Scopus citations
2017

A step toward high reliability: Implementation of a daily safety brief in a Children's Hospital

Saysana, M., Mccaskey, M., Cox, E., Thompson, R., Tuttle, L. K. & Haut, P. R., Sep 1 2017, In : Journal of Patient Safety. 13, 3, p. 149-152 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Holmberg, D., Franzén-Röhl, E., Idro, R., Opoka, R. O., Bangirana, P., Sellgren, C. M., Wickström, R., Färnert, A., Schwieler, L., Engberg, G. & John, C. C., Jul 28 2017, In : Malaria Journal. 16, 1, 303.

Research output: Contribution to journalArticle

10 Scopus citations

Clinical comparison of retinopathy-positive and retinopathy-negative cerebral Malaria

Villaverde, C., Namazzi, R., Shabani, E., Opoka, R. O. & John, C., 2017, In : American Journal of Tropical Medicine and Hygiene. 96, 5, p. 1176-1184 9 p.

Research output: Contribution to journalArticle

12 Scopus citations