Pediatric Infectious Disease

Publications 1985 2020

21 Citations (Scopus)

Cerebral malaria is associated with long-term mental health disorders: A cross sectional survey of a long-term cohort

Idro, R., Kakooza-Mwesige, A., Asea, B., Ssebyala, K., Bangirana, P., Opoka, R. O., Lubowa, S. K., Semrud-Clikeman, M., John, C. & Nalugya, J., Mar 31 2016, In : Malaria Journal. 15, 1, 184.

Research output: Contribution to journalArticle

Cerebral Malaria
Mental Disorders
Mental Health
Cross-Sectional Studies
Anemia
4 Citations (Scopus)

Cerebral malaria pathogenesis: What can we learn from microarray analysis?

John, C. C., Dec 2007, In : American Journal of Pathology. 171, 6, p. 1729-1732 4 p.

Research output: Contribution to journalComment/debate

Cerebral Malaria
Microarray Analysis
101 Citations (Scopus)

Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria

John, C. C., Panoskaltsis-Mortari, A., Opoka, R. O., Park, G. S., Orchard, P. J., Jurek, A. M., Idro, R., Byarugaba, J. & Boivin, M. J., Feb 1 2008, In : American Journal of Tropical Medicine and Hygiene. 78, 2, p. 198-205 8 p.

Research output: Contribution to journalArticle

Cerebral Malaria
Cerebrospinal Fluid
Cytokines
Tumor Necrosis Factor-alpha
Granulocyte Colony-Stimulating Factor
8 Citations (Scopus)

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Holmberg, D., Franzén-Röhl, E., Idro, R., Opoka, R. O., Bangirana, P., Sellgren, C. M., Wickström, R., Färnert, A., Schwieler, L., Engberg, G. & John, C., Jul 28 2017, In : Malaria Journal. 16, 1, 303.

Research output: Contribution to journalArticle

Kynurenic Acid
Cerebral Malaria
Kynurenine
Coma
Cerebrospinal Fluid
4 Citations (Scopus)

Changes in antigen-specific cytokine and chemokine responses to Plasmodium falciparum antigens in a highland area of kenya after a prolonged absence of malaria exposure

Ochola, L. A., Ayieko, C., Kisia, L., Magak, N. G., Shabani, E., Ouma, C. & John, C. C., 2014, In : Infection and immunity. 82, 9, p. 3775-3782 8 p.

Research output: Contribution to journalArticle

Kenya
Plasmodium falciparum
Chemokines
Malaria
Cytokines
19 Citations (Scopus)

Changes in B Cell Populations and Merozoite Surface Protein-1-Specific Memory B Cell Responses after Prolonged Absence of Detectable P. falciparum Infection

Ayieko, C., Maue, A. C., Jura, W. G. Z. O., Noland, G. S., Ayodo, G., Rochford, R. & John, C. C., Jun 27 2013, In : PLoS ONE. 8, 6, e67230.

Research output: Contribution to journalArticle

Merozoite Surface Protein 1
merozoites
surface proteins
B-lymphocytes
B-Lymphocytes
6 Citations (Scopus)

Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individuals

Nguyen, T. V., Sacci, J. B., De La Vega, P., John, C. C., James, A. A. & Kang, A. S., Dec 28 2009, In : Malaria Journal. 8, 1, 235.

Research output: Contribution to journalArticle

Sporozoites
Plasmodium falciparum
Surface Antigens
Malaria
Immunoglobulin G
3 Citations (Scopus)

Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria NCT01255215 NCT

Conroy, A. L., Hawkes, M. T., Elphinstone, R., Opoka, R. O., Namasopo, S., Miller, C., John, C. & Kain, K. C., Feb 15 2018, In : Malaria Journal. 17, 1, 82.

Research output: Contribution to journalArticle

Chitinases
Acute Kidney Injury
Malaria
Biomarkers
Pediatrics

Chloramphenicol toxicity

Christenson, J. C. & Marks, M. I., Nov 1986, In : The Journal of pediatrics. 109, 5, 1 p.

Research output: Contribution to journalLetter

Drug Synergism
Phenytoin
Chloramphenicol
11 Citations (Scopus)

Clinical comparison of retinopathy-positive and retinopathy-negative cerebral Malaria

Villaverde, C., Namazzi, R., Shabani, E., Opoka, R. O. & John, C., 2017, In : American Journal of Tropical Medicine and Hygiene. 96, 5, p. 1176-1184 9 p.

Research output: Contribution to journalArticle

Cerebral Malaria
Physical Examination
Retinal Hemorrhage
Uganda
Parasitemia
26 Citations (Scopus)

Clinical manifestations of severe malaria in the highlands of Southwestern Uganda

Idro, R., Bitarakwate, E., Tumwesigire, S. & John, C. C., May 1 2005, In : American Journal of Tropical Medicine and Hygiene. 72, 5, p. 561-567 7 p.

Research output: Contribution to journalArticle

Uganda
Malaria
Confidence Intervals
Splenomegaly
Consciousness
16 Citations (Scopus)

Clinicians' response to computerized detection of infections

Rocha, B. H. S. C., Christenson, J. C., Evans, R. S. & Gardner, R. M., Jan 1 2001, In : Journal of the American Medical Informatics Association. 8, 2, p. 117-125 9 p.

Research output: Contribution to journalArticle

Open Access
Infection
Physician Assistants
Expert Systems
Pediatric Intensive Care Units
Pediatric Hospitals
29 Citations (Scopus)

Cognition, behaviour and academic skills after cognitive rehabilitation in Ugandan children surviving severe malaria: A randomised trial

Bangirana, P., Allebeck, P., Boivin, M. J., John, C. C., Page, C., Ehnvall, A. & Musisi, S., Aug 4 2011, In : BMC Neurology. 11, 96.

Research output: Contribution to journalArticle

Child Behavior
Checklist
Cognition
Malaria
Rehabilitation
147 Citations (Scopus)

Cognitive impairment after cerebral malaria in children: A prospective study

Boivin, M. J., Bangirana, P., Byarugaba, J., Opoka, R. O., Idro, R., Jurek, A. M. & John, C. C., Feb 1 2007, In : Pediatrics. 119, 2, p. e360-e366

Research output: Contribution to journalArticle

Cerebral Malaria
Prospective Studies
Short-Term Memory
Malaria
Cognitive Dysfunction
1 Citation (Scopus)

Community-acquired, non-antibiotic-associated Clostridium difficile colitis in a child

Auletta, J. J. & John, C. C., Jan 1 2002, In : Infectious Diseases in Clinical Practice. 11, 7, p. 397-398 2 p.

Research output: Contribution to journalArticle

Clostridium difficile
Colitis

Community perceptions of paediatric severe anaemia in Uganda

Dhabangi, A., Idro, R., John, C., Dzik, W. H., Siu, G. E., Opoka, R. O., Ayebare, F. & Van Hensbroek, M. B., Jan 1 2019, In : PLoS One. 14, 1, e0209476.

Research output: Contribution to journalArticle

Pediatrics
Uganda
anemia
Anemia
splenomegaly
12 Citations (Scopus)

Comparative efficacy and safety of cefprozil (BMY-28100) and cefaclor in the treatment of acute group A beta-hemolytic streptococcal pharyngitis

Christenson, J. C., Swenson, E., Gooch, W. M. & Herrod, J. N., Jan 1 1991, In : Antimicrobial Agents and Chemotherapy. 35, 6, p. 1127-1130 4 p.

Research output: Contribution to journalArticle

Open Access
Cefaclor
Pharyngitis
Safety
Therapeutics
Nausea
8 Citations (Scopus)

Comparative efficacy and safety of cefprozil and cefaclor in the treatment of acute uncomplicated urinary tract infections

Christenson, J. C., Gooch, W. M., Herrod, J. N. & Swenson, E., Oct 1 1991, In : Journal of Antimicrobial Chemotherapy. 28, 4, p. 581-586 6 p.

Research output: Contribution to journalArticle

Cefaclor
Pathogens
Antibiotics
Urinary Tract Infections
Acute

Comparison of non-magnetic and magnetic beads multiplex assay for assessment of Plasmodium falciparum antibodies

Ondigo, B. N., Park, G. S., Ayieko, C., Nyangahu, D. D., Wasswa, R. & John, C., Jan 1 2019, In : PeerJ. 2019, 1, e6120.

Research output: Contribution to journalArticle

Plasmodium falciparum
Assays
Antigens
antibodies
Antibodies

Comparison of Risk of Recrudescent Fever in Children With Kawasaki Disease Treated With Intravenous Immunoglobulin and Low-Dose vs High-Dose Aspirin

Platt, B., Belarski, E., Manaloor, J., Ofner, S., Carroll, A. E., John, C. C. & Wood, J. B., Jan 3 2020, In : JAMA Network Open. 3, 1, p. e1918565

Research output: Contribution to journalArticle

Open Access
Mucocutaneous Lymph Node Syndrome
Intravenous Immunoglobulins
Aspirin
Fever
Coronary Vessels
1 Citation (Scopus)

Complex interactions of HIV infection, malaria, and iron deficiency

John, C. C., Dec 1 2013, In : Clinical Infectious Diseases. 57, 11, p. 1635-1637 3 p.

Research output: Contribution to journalComment/debate

Malaria
HIV Infections
Anemia
Acquired Immunodeficiency Syndrome
Iron
13 Citations (Scopus)
Expert Systems
Cross Infection
Newborn Infant
Physicians
Knowledge Bases

Concomitant Fundoplication with Gastrostomy: A Two-State Comparison Showing Continued Use of Reflux Medications

Fox, D., Campagna, E. J., Finnell, S. M., Partrick, D. A. & Kempe, A., Apr 8 2016, (Accepted/In press) In : Journal of Pediatric Gastroenterology and Nutrition.

Research output: Contribution to journalArticle

Fundoplication
Gastrostomy
Medicaid
Observational Studies
Prescriptions
6 Citations (Scopus)

Conversion of a single-facility pediatric antimicrobial stewardship program to multi-facility application with computerized provider order entry and clinical decision support

Webber, E. C., Warhurst, H. M., Smith, S. S., Cox, E. G., Crumby, A. S. & Nichols, K. R., Dec 1 2013, In : Applied Clinical Informatics. 4, 4, p. 556-568 13 p.

Research output: Contribution to journalArticle

Medical Order Entry Systems
Clinical Decision Support Systems
Pediatrics
Health
Workflow
86 Citations (Scopus)

Correlation of high levels of antibodies to multiple pre-erythrocytic Plasmodium falciparum antigens and protection from infection

John, C. C., Moormann, A. M., Pregibon, D. C., Sumba, P. O., McHugh, M. M., Narum, D. L., Lanar, D. E., Schluchter, M. D. & Kazura, J. W., Jul 1 2005, In : American Journal of Tropical Medicine and Hygiene. 73, 1, p. 222-228 7 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Antigens
Antibodies
Infection
Malaria
40 Citations (Scopus)

Cytokine responses to Plasmodium falciparum liver-stage antigen 1 vary in rainy and dry seasons in highland Kenya

John, C. C., Sumba, P. O., Ouma, J. H., Nahlen, B. L., King, C. L. & Kazura, J. W., Sep 14 2000, In : Infection and immunity. 68, 9, p. 5198-5204 7 p.

Research output: Contribution to journalArticle

Kenya
Plasmodium falciparum
Interleukin-10
Cytokines
Antigens
12 Citations (Scopus)

Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya

Frosch, A. E. P., Ondigo, B. N., Ayodo, G. A., Vulule, J. M., John, C. C. & Cusick, S. E., Sep 1 2014, In : American Journal of Clinical Nutrition. 100, 3, p. 968-973 6 p.

Research output: Contribution to journalArticle

Kenya
Malaria
Iron
Hemoglobins
Ferritins
2 Citations (Scopus)
Methicillin-Resistant Staphylococcus aureus
Abscess
Communicable Diseases
Drainage
Cohort Studies
7 Citations (Scopus)

Decreased prevalence of anemia in highland areas of low malaria transmission after a 1-year interruption of transmission

Noland, G. S., Ayodo, G., Abuya, J., Hodges, J. S., Rolfes, M. A. R. & John, C. C., Jan 15 2012, In : Clinical Infectious Diseases. 54, 2, p. 178-184 7 p.

Research output: Contribution to journalArticle

Malaria
Anemia
Confidence Intervals
Kenya
Insecticides
7 Citations (Scopus)

Decrease in numbers of naive and resting B cells in HIV-infected Kenyan Adults leads to a proportional increase in total and plasmodium falciparum-specific atypical memory B cells

Frosch, A. E., Odumade, O. A., Taylor, J. J., Ireland, K., Ayodo, G., Ondigo, B., Narum, D. L., Vulule, J. & John, C., Jun 15 2017, In : Journal of Immunology. 198, 12, p. 4629-4638 10 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
B-Lymphocytes
HIV
HIV-1
Membranes
9 Citations (Scopus)

Delaying Iron therapy until 28 days after antimalarial treatment is associated with greater Iron incorporation and equivalent hematologic recovery after 56 days in children: A randomized controlled trial

Cusick, S. E., Opoka, R. O., Abrams, S. A., John, C., Georgieff, M. K. & Mupere, E., 2016, In : Journal of Nutrition. 146, 9, p. 1769-1774 6 p.

Research output: Contribution to journalArticle

Antimalarials
Iron
Randomized Controlled Trials
Therapeutics
Hemoglobins
1 Citation (Scopus)

Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiency

Jaramillo, E. G., Mupere, E., Opoka, R. O., Hodges, J. S., Lund, T. C., Georgieff, M. K., John, C. & Cusick, S. E., Aug 1 2017, In : PLoS One. 12, 8, e0183977.

Research output: Contribution to journalArticle

antimalarials
Antimalarials
malaria
Malaria
Iron
5 Citations (Scopus)

Detection of vancomycin-resistant enterococci colonization in a children's hospital

Christenson, J. C., Korgenski, E. K., Jenkins, E. & Daly, J. A., Jan 1 1998, In : American Journal of Infection Control. 26, 6, p. 569-571 3 p.

Research output: Contribution to journalArticle

Pediatric Hospitals
Vancomycin
Infection Control
Anti-Infective Agents
Tertiary Care Centers
7 Citations (Scopus)
Mentors
Qualitative Research
mentoring
qualitative research
Students
99 Citations (Scopus)

Development and impact of a computerized pediatric antiinfective decision support program.

Mullett, C. J., Evans, R. S., Christenson, J. C. & Dean, J. M., Oct 2001, In : Pediatrics. 108, 4, p. E75

Research output: Contribution to journalArticle

Pediatric Intensive Care Units
Pediatrics
Anti-Infective Agents
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
39 Citations (Scopus)

Development of a competency-based curriculum in global child health

Howard, C. R., Gladding, S. P., Kiguli, S., Andrews, J. S. & John, C. C., Apr 2011, In : Academic Medicine. 86, 4, p. 521-528 8 p.

Research output: Contribution to journalArticle

Curriculum
curriculum
Internship and Residency
health
resident
12 Citations (Scopus)

Development of clinical immunity to malaria in highland areas of low and unstable transmission

Rolfes, M. A., McCarra, M., Magak, N. G., Ernst, K. C., Dent, A. E., Lindblade, K. A. & John, C. C., Nov 1 2012, In : American Journal of Tropical Medicine and Hygiene. 87, 5, p. 806-812 7 p.

Research output: Contribution to journalArticle

Malaria
Immunity
Incidence
Parasites
Kenya
1 Citation (Scopus)

Diagnosing latent tuberculosis in international adoptees remains challenging

Howard, C. R. & John, C. C., Nov 2011, In : Journal of Pediatrics. 159, 5, p. 873-874 2 p.

Research output: Contribution to journalArticle

Latent Tuberculosis
5 Citations (Scopus)

Differing causes of lactic acidosis and deep breathing in cerebral malaria and severe malarial anemia may explain differences in acidosis-related mortality

Brand, N. R., Opoka, R. O., Hamre, K. E. S. & John, C., Sep 1 2016, In : PLoS One. 11, 9, e0163728.

Research output: Contribution to journalArticle

Cerebral Malaria
Lactic Acidosis
acidosis
Acidosis
anemia
34 Citations (Scopus)

Discriminators between hantavirus-infected and -uninfected persons enrolled in a trial of intravenous ribavirin for presumptive hantavirus pulmonary syndrome

Chapman, L. E., Ellis, B. A., Koster, F. T., Sotir, M., Ksiazek, T. G., Mertz, G. J., Rollin, P. E., Baum, K. F., Pavia, A. T., Christenson, J. C., Rubin, P. J., Jolson, H. M., Behrman, R. E., Khan, A. S., Wilson Bell, L. J., Simpson, G. L., Hawk, J., Holman, R. C. & Peters, C. J., Feb 1 2002, In : Clinical Infectious Diseases. 34, 3, p. 293-304 12 p.

Research output: Contribution to journalArticle

Hantavirus Pulmonary Syndrome
Hantavirus
Ribavirin
Granulocyte Precursor Cells
Hospitalization
4 Citations (Scopus)

Drug treatment of malaria in children

John, C. C., Jul 1 2003, In : Pediatric Infectious Disease Journal. 22, 7, p. 649-651 3 p.

Research output: Contribution to journalShort survey

Drug Dose Response Relationship
Severity of Illness Index
Drug Administration Schedule
Plasmodium malariae
Vivax Malaria
Protozoan Antibodies
Protozoan Antigens
Protozoan Proteins
Malaria Vaccines
Falciparum Malaria
16 Citations (Scopus)

Effect of transmission intensity and age on subclass antibody responses to Plasmodium falciparum pre-erythrocytic and blood-stage antigens

Noland, G. S., Jansen, P., Vulule, J. M., Park, G. S., Ondigo, B. N., Kazura, J. W., Moormann, A. M. & John, C. C., Feb 1 2015, In : Acta Tropica. 142, p. 47-56 10 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Antibody Formation
Immunoglobulin G
antigens
Antigens
13 Citations (Scopus)

Efficacy model for antibody-mediated pre-erythrocytic malaria vaccines

White, M. T., Griffin, J. T., Riley, E. M., Drakeley, C. J., Moorman, A. M., Sumba, P. O., Kazura, J. W., Ghani, A. C. & John, C. C., Jan 1 2011, In : Proceedings of the Royal Society B: Biological Sciences. 278, 1710, p. 1298-1305 8 p.

Research output: Contribution to journalArticle

Malaria Vaccines
malaria
vaccine
antibody
Thrombospondins
6 Citations (Scopus)

Efficacy of limited cefuroxime prophylaxis in pediatric patients after cardiovascular surgery

Knoderer, C. A., Cox, E. G., Berg, M. D., Webster, A. H. & Turrentine, M. W., May 15 2011, In : American Journal of Health-System Pharmacy. 68, 10, p. 909-914 6 p.

Research output: Contribution to journalArticle

Cefuroxime
Pediatrics
Infection
Biomarkers
Laboratory Infection
8 Citations (Scopus)

Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria

Shabani, E., Ouma, B. J., Idro, R., Bangirana, P., Opoka, R. O., Park, G. S., Conroy, A. L. & John, C., Jul 1 2017, In : Parasite Immunology. 39, 7, e12438.

Research output: Contribution to journalArticle

Cerebral Malaria
Cerebrospinal Fluid
Tumor Necrosis Factor-alpha
Neurologic Manifestations
Central Nervous System
30 Citations (Scopus)

Elevated serum levels of IL-1ra in children with Plasmodium falciparum malaria are associated with increased severity of disease

John, C. C., Park, G. S., Sam-Agudu, N., Opoka, R. O. & Boivin, M. J., Mar 1 2008, In : Cytokine. 41, 3, p. 204-208 5 p.

Research output: Contribution to journalArticle

Interleukin-1 Receptors
Falciparum Malaria
Cerebral Malaria
Chemokine CCL2
Granulocyte Colony-Stimulating Factor
38 Citations (Scopus)

Environmental, socio-demographic and behavioural determinants of malaria risk in the western Kenyan highlands: A case-control study

Ernst, K. C., Lindblade, K. A., Koech, D., Sumba, P. O., Kuwuor, D. O., John, C. C. & Wilson, M. L., Oct 1 2009, In : Tropical Medicine and International Health. 14, 10, p. 1258-1265 8 p.

Research output: Contribution to journalArticle

Malaria
Case-Control Studies
Demography
Wetlands
Eastern Africa

Erratum: A family cluster of five cases of group A Streptococcal pneumonia (Pediatrics (July 2003) 112 (e61-e65))

Roy, S., Kaplan, E. L., Rodriguez, B., Schreiber, J. R., Salata, R. A., Palavecino, E. & John, C. C., Sep 1 2003, In : Pediatrics. 112, 3 I, 1 p.

Research output: Contribution to journalComment/debate

Pneumonia
Pediatrics
Paramyxoviridae Infections
Virus Diseases
Human Influenza
Pediatrics