Pediatric Infectious Disease

Publications 1991 2019

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2019
1 Citation (Scopus)

Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria

Conroy, A. L., Opoka, R. O., Bangirana, P., Idro, R., Ssenkusu, J. M., Datta, D., Hodges, J. S., Morgan, C. & John, C., May 21 2019, In : BMC medicine. 17, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Chronic Renal Insufficiency
Acute Kidney Injury
Cognition
Malaria
Odds Ratio
1 Citation (Scopus)

Adherence to clinical guidelines is associated with reduced inpatient mortality among children with severe anemia in Ugandan hospitals

Opoka, R. O., Ssemata, A. S., Oyang, W., Nambuya, H., John, C., Karamagi, C. & Tumwine, J. K., Jan 1 2019, In : PLoS One. 14, 1, e0210982.

Research output: Contribution to journalArticle

Child Mortality
anemia
Anemia
Inpatients
Guidelines

Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria

Rivera-Correa, J., Conroy, A. L., Opoka, R. O., Batte, A., Namazzi, R., Ouma, B., Bangirana, P., Idro, R., Schwaderer, A. L., John, C. C. & Rodriguez, A., Dec 1 2019, In : Scientific reports. 9, 1, 14940.

Research output: Contribution to journalArticle

Open Access
Phosphatidylserines
Acute Kidney Injury
Autoantibodies
Malaria
Anemia

Caregivers and community perceptions of blood transfusion for children with severe anaemia in Uganda

Dhabangi, A., Idro, R., John, C., Dzik, W. H., Opoka, R., Siu, G. E., Ayebare, F. & van Hensbroek, M. B., Feb 1 2019, In : Transfusion Medicine. 29, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

Uganda
Blood Transfusion
Caregivers
Anemia
HIV
1 Citation (Scopus)

Case Report: Birth Outcome and Neurodevelopment in Placental Malaria Discordant Twins

Conroy, A. L., Bangirana, P., Muhindo, M. K., Kakuru, A., Jagannathan, P., Opoka, R. O., Liechty, E. A., Nakalembe, M., Kamya, M. R., Dorsey, G. & John, C., Mar 1 2019, In : The American journal of tropical medicine and hygiene. 100, 3, p. 552-555 4 p.

Research output: Contribution to journalArticle

Malaria
Parturition
Pregnancy
Placenta
Language

Community perceptions of paediatric severe anaemia in Uganda

Dhabangi, A., Idro, R., John, C., Dzik, W. H., Siu, G. E., Opoka, R. O., Ayebare, F. & Van Hensbroek, M. B., Jan 1 2019, In : PLoS One. 14, 1, e0209476.

Research output: Contribution to journalArticle

Pediatrics
Uganda
anemia
Anemia
splenomegaly

Comparison of non-magnetic and magnetic beads multiplex assay for assessment of Plasmodium falciparum antibodies

Ondigo, B. N., Park, G. S., Ayieko, C., Nyangahu, D. D., Wasswa, R. & John, C., Jan 1 2019, In : PeerJ. 2019, 1, e6120.

Research output: Contribution to journalArticle

Plasmodium falciparum
Assays
Antigens
antibodies
Antibodies

HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya

Odhiambo, E. O., Datta, D., Guyah, B., Ayodo, G., Ondigo, B. N., Abong'O, B. O., John, C. & Frosch, A. E. P., Aug 30 2019, In : Malaria Journal. 18, 1, 297.

Research output: Contribution to journalArticle

Open Access
Kenya
Plasmodium falciparum
HIV Infections
Immunoglobulin M
Immunoglobulins
Open Access
Microbiology
Malaria
Health
Mortality
2 Citations (Scopus)

Whole-Blood Transcriptional Signatures Composed of Erythropoietic and NRF2-Regulated Genes Differ Between Cerebral Malaria and Severe Malarial Anemia

Nallandhighal, S., Park, G. S., Ho, Y. Y., Opoka, R. O., John, C. & Tran, T., Jan 1 2019, In : The Journal of infectious diseases. 219, 1, p. 154-164 11 p.

Research output: Contribution to journalArticle

Cerebral Malaria
Anemia
Genes
Reticulocytes
Malaria

Zinc for infection prevention in sickle cell anemia (zips): Study protocol for a randomized placebo-controlled trial in ugandan children with sickle cell anemia

Datta, D., Namazzi, R., Conroy, A. L., Cusick, S. E., Hume, H. A., Tagoola, A., Ware, R. E., Opoka, R. O. & John, C., Jul 26 2019, In : Trials. 20, 1, 460.

Research output: Contribution to journalArticle

Open Access
Sickle Cell Anemia
Zinc
Randomized Controlled Trials
Placebos
Infection
2018
4 Citations (Scopus)

Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes

Postels, D. G., Wu, X., Li, C., Kaplan, P. W., Seydel, K. B., Taylor, T. E., Kousa, Y. A., Idro, R., Opoka, R., John, C. & Birbeck, G. L., May 22 2018, In : Malaria Journal. 17, 1, 208.

Research output: Contribution to journalArticle

Cerebral Malaria
Electroencephalography
Pediatrics
Uganda
Population
1 Citation (Scopus)

Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria NCT01255215 NCT

Conroy, A. L., Hawkes, M. T., Elphinstone, R., Opoka, R. O., Namasopo, S., Miller, C., John, C. & Kain, K. C., Feb 15 2018, In : Malaria Journal. 17, 1, 82.

Research output: Contribution to journalArticle

Chitinases
Acute Kidney Injury
Malaria
Biomarkers
Pediatrics
1 Citation (Scopus)

High rate of inappropriate blood transfusions in the management of children with severe anemia in Ugandan hospitals

Opoka, R. O., Ssemata, A. S., Oyang, W., Nambuya, H., John, C., Tumwine, J. K. & Karamagi, C., Jul 18 2018, In : BMC Health Services Research. 18, 1, 566.

Research output: Contribution to journalArticle

Blood Transfusion
Anemia
Hemoglobins
Inpatients
Uganda
4 Citations (Scopus)

Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial

Bangirana, P., Conroy, A. L., Opoka, R. O., Hawkes, M. T., Hermann, L., Miller, C., Namasopo, S., Liles, W. C., John, C. & Kain, K. C., Jan 1 2018, In : PLoS One. 13, 1, e0191550.

Research output: Contribution to journalArticle

Pediatrics
cognition
malaria
Cognition
Malaria
3 Citations (Scopus)

Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia

Opoka, R. O., Bangirana, P., Idro, R., Shabani, E., Namazzi, R. & John, C., Jan 1 2018, In : Pediatric Blood and Cancer. 65, 1, e26745.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Sickle Hemoglobin
Anemia
Child Mortality
Malaria
6 Citations (Scopus)

Sharing antimicrobial reports for pediatric stewardship (SHARPS): A quality improvement collaborative

SHARPS Collaborative, Jan 1 2018, In : Journal of the Pediatric Infectious Diseases Society. 7, 2, p. 124-128 5 p.

Research output: Contribution to journalArticle

Quality Improvement
Pediatrics
Benchmarking
Learning
Hospitalized Child
1 Citation (Scopus)

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa

Taylor, W. R., Naw, H. K., Maitland, K., Williams, T. N., Kapulu, M., D'Alessandro, U., Berkley, J. A., Bejon, P., Okebe, J., Achan, J., Amambua, A. N., Affara, M., Nwakanma, D., van Geertruyden, J. P., Mavoko, M., Lutumba, P., Matangila, J., Brasseur, P., Piola, P., Randremanana, R. & 24 others, Lasry, E., Fanello, C., Onyamboko, M., Schramm, B., Yah, Z., Jones, J., Fairhurst, R. M., Diakite, M., Malenga, G., Molyneux, M., Rwagacondo, C., Obonyo, C., Gadisa, E., Aseffa, A., Loolpapit, M., Henry, M. C., Dorsey, G., John, C., Sirima, S. B., Barnes, K. I., Kremsner, P., Day, N. P., White, N. J. & Mukaka, M., Jan 18 2018, In : BMC Medicine. 16, 1, 11.

Research output: Contribution to journalArticle

Primaquine
Falciparum Malaria
Africa South of the Sahara
Anemia
Glucosephosphate Dehydrogenase Deficiency
2017
7 Citations (Scopus)

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Holmberg, D., Franzén-Röhl, E., Idro, R., Opoka, R. O., Bangirana, P., Sellgren, C. M., Wickström, R., Färnert, A., Schwieler, L., Engberg, G. & John, C., Jul 28 2017, In : Malaria Journal. 16, 1, 303.

Research output: Contribution to journalArticle

Kynurenic Acid
Cerebral Malaria
Kynurenine
Coma
Cerebrospinal Fluid
10 Citations (Scopus)

Clinical comparison of retinopathy-positive and retinopathy-negative cerebral Malaria

Villaverde, C., Namazzi, R., Shabani, E., Opoka, R. O. & John, C., 2017, In : American Journal of Tropical Medicine and Hygiene. 96, 5, p. 1176-1184 9 p.

Research output: Contribution to journalArticle

Cerebral Malaria
Physical Examination
Retinal Hemorrhage
Uganda
Parasitemia
5 Citations (Scopus)

Decrease in numbers of naive and resting B cells in HIV-infected Kenyan Adults leads to a proportional increase in total and plasmodium falciparum-specific atypical memory B cells

Frosch, A. E., Odumade, O. A., Taylor, J. J., Ireland, K., Ayodo, G., Ondigo, B., Narum, D. L., Vulule, J. & John, C., Jun 15 2017, In : Journal of Immunology. 198, 12, p. 4629-4638 10 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
B-Lymphocytes
HIV
HIV-1
Membranes
1 Citation (Scopus)

Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiency

Jaramillo, E. G., Mupere, E., Opoka, R. O., Hodges, J. S., Lund, T. C., Georgieff, M. K., John, C. & Cusick, S. E., Aug 1 2017, In : PLoS One. 12, 8, e0183977.

Research output: Contribution to journalArticle

antimalarials
Antimalarials
malaria
Malaria
Iron
5 Citations (Scopus)
Mentors
Qualitative Research
mentoring
qualitative research
Students

Development of research capacity in sickle cell anemia in Uganda: Impact of collaborations

Namazzi, R., John, C. C., Conroy, A. L., Datta, D., Ware, R., Hume, H. & Opoka, R. O., Dec 8 2017, In : Blood Advances. 1, p. 11-13 3 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria

Shabani, E., Ouma, B. J., Idro, R., Bangirana, P., Opoka, R. O., Park, G. S., Conroy, A. L. & John, C., Jul 1 2017, In : Parasite Immunology. 39, 7, e12438.

Research output: Contribution to journalArticle

Cerebral Malaria
Cerebrospinal Fluid
Tumor Necrosis Factor-alpha
Neurologic Manifestations
Central Nervous System
5 Citations (Scopus)

Impact of a national guideline on antibiotic selection for hospitalized pneumonia

Pediatric Research in Inpatient Settings Network, Apr 1 2017, In : Pediatrics. 139, 4, e20163231.

Research output: Contribution to journalArticle

Pneumonia
Guidelines
Anti-Bacterial Agents
Penicillins
Publications
1 Citation (Scopus)

Interferon- γ responses to Plasmodium falciparum vaccine candidate antigens decrease in the absence of malaria transmission

Ayieko, C., Ogola, B. S., Ochola, L., Ngwena, G. A. M., Ayodo, G., Hodges, J. S., Noland, G. S. & John, C., 2017, In : PeerJ. 2017, 1, e2855.

Research output: Contribution to journalArticle

Plasmodium falciparum
interferons
malaria
Interferons
Malaria
25 Citations (Scopus)

Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia

Opoka, R. O., Ndugwa, C. M., Latham, T. S., Lane, A., Hume, H. A., Kasirye, P., Hodges, J. S., Ware, R. E. & John, C., Dec 14 2017, In : Blood. 130, 24, p. 2585-2593 9 p.

Research output: Contribution to journalArticle

Hydroxyurea
Sickle Cell Anemia
Malaria
Placebos
Africa South of the Sahara
9 Citations (Scopus)

Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria

Shabani, E., Hanisch, B., Opoka, R. O., Lavstsen, T. & John, C., Oct 13 2017, In : BMC Medicine. 15, 1, 183.

Research output: Contribution to journalArticle

Cerebral Malaria
Plasmodium falciparum
Protein C
Malaria
Plasmodium falciparum erythrocyte membrane protein 1

Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya

Weber, G. E., White, M. T., Babakhanyan, A., Sumba, P. O., Vulule, J., Ely, D., John, C., Angov, E., Lanar, D., Dutta, S., Narum, D. L., Horii, T., Cowman, A., Beeson, J., Smith, J., Kazura, J. W. & Dent, A. E., Dec 1 2017, In : Scientific Reports. 7, 1, 16821.

Research output: Contribution to journalArticle

Catalytic Antibodies
Kenya
Malaria
Antibodies
Antigens
6 Citations (Scopus)

Supporting global health at the pediatric department level: Why and how

Pitt, M. B., Moore, M. A., John, C., Batra, M., Butteris, S. M., Airewele, G. E., Suchdev, P. S. & Steinhoff, M. C., Jun 1 2017, In : Pediatrics. 139, 6, e20163939.

Research output: Contribution to journalArticle

Pediatrics
Global Health

The Benjamin H. Kean travel fellowship in tropical medicine: Assessment of impact at 15 years

Carman, A. S. & John, C., 2017, In : American Journal of Tropical Medicine and Hygiene. 97, 3, p. 958-963 6 p.

Research output: Contribution to journalArticle

Tropical Medicine
Foster Home Care
Professional Practice
Manuscripts
Postal Service
2016
19 Citations (Scopus)

Acute kidney injury is common in pediatric severe malaria and is associated with increased mortality

Conroy, A. L., Hawkes, M., Elphinstone, R. E., Morgan, C., Hermann, L., Barker, K. R., Namasopo, S., Opoka, R. O., John, C., Liles, W. C. & Kain, K. C., Apr 1 2016, In : Open Forum Infectious Diseases. 3, 2, ofw046.

Research output: Contribution to journalArticle

Acute Kidney Injury
Malaria
Pediatrics
Mortality
Cystatin C
11 Citations (Scopus)

Alterations in Systemic Extracellular Heme and Hemopexin Are Associated with Adverse Clinical Outcomes in Ugandan Children with Severe Malaria

Elphinstone, R. E., Conroy, A. L., Hawkes, M., Hermann, L., Namasopo, S., Warren, H. S., John, C., Liles, W. C. & Kain, K. C., Oct 15 2016, In : Journal of Infectious Diseases. 214, 8, p. 1268-1275 8 p.

Research output: Contribution to journalArticle

Hemopexin
Heme
Malaria
Acute Kidney Injury
Hemin
16 Citations (Scopus)

An Evaluation of Various Ventilator-Associated Infection Criteria in a PICU

Beardsley, A. L., Nitu, M., Cox, E. & Benneyworth, B. D., Jan 1 2016, In : Pediatric Critical Care Medicine. 17, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

Mechanical Ventilators
Infection
Ventilator-Associated Pneumonia
Artificial Respiration
Respiratory Tract Infections
18 Citations (Scopus)

Cerebral malaria is associated with long-term mental health disorders: A cross sectional survey of a long-term cohort

Idro, R., Kakooza-Mwesige, A., Asea, B., Ssebyala, K., Bangirana, P., Opoka, R. O., Lubowa, S. K., Semrud-Clikeman, M., John, C. & Nalugya, J., Mar 31 2016, In : Malaria Journal. 15, 1, 184.

Research output: Contribution to journalArticle

Cerebral Malaria
Mental Disorders
Mental Health
Cross-Sectional Studies
Anemia

Concomitant Fundoplication with Gastrostomy: A Two-State Comparison Showing Continued Use of Reflux Medications

Fox, D., Campagna, E. J., Finnell, S. M., Partrick, D. A. & Kempe, A., Apr 8 2016, (Accepted/In press) In : Journal of Pediatric Gastroenterology and Nutrition.

Research output: Contribution to journalArticle

Fundoplication
Gastrostomy
Medicaid
Observational Studies
Prescriptions
9 Citations (Scopus)

Delaying Iron therapy until 28 days after antimalarial treatment is associated with greater Iron incorporation and equivalent hematologic recovery after 56 days in children: A randomized controlled trial

Cusick, S. E., Opoka, R. O., Abrams, S. A., John, C., Georgieff, M. K. & Mupere, E., 2016, In : Journal of Nutrition. 146, 9, p. 1769-1774 6 p.

Research output: Contribution to journalArticle

Antimalarials
Iron
Randomized Controlled Trials
Therapeutics
Hemoglobins
4 Citations (Scopus)

Differing causes of lactic acidosis and deep breathing in cerebral malaria and severe malarial anemia may explain differences in acidosis-related mortality

Brand, N. R., Opoka, R. O., Hamre, K. E. S. & John, C., Sep 1 2016, In : PLoS One. 11, 9, e0163728.

Research output: Contribution to journalArticle

Cerebral Malaria
Lactic Acidosis
acidosis
Acidosis
anemia

Hepatitis A, B, and C

Christenson, J. & Manaloor, J. J., Oct 1 2016, In : Pediatrics in Review. 37, 10, p. 426-438 13 p.

Research output: Contribution to journalArticle

Hepatitis A
Hepatitis C
Hepatitis B
Hepatitis Viruses
Passive Immunization
4 Citations (Scopus)

Host biomarkers are associated with response to therapy and long-term mortality in pediatric severe malaria

Conroy, A. L., Hawkes, M., McDonald, C. R., Kim, H., Higgins, S. J., Barker, K. R., Namasopo, S., Opoka, R. O., John, C., Liles, W. C. & Kain, K. C., 2016, In : Open Forum Infectious Diseases. 3, 3, ofw134.

Research output: Contribution to journalArticle

Angiopoietin-2
Malaria
Biomarkers
Pediatrics
Mortality
1 Citation (Scopus)

Longevity of genotype-specific immune responses to Plasmodium falciparum merozoite surface protein 1 in Kenyan children from regions of different malaria transmission intensity

Bowman, N. M., Juliano, J. J., Snider, C. J., Kharabora, O., Meshnick, S. R., Vulule, J., John, C. & Moormann, A. M., Sep 1 2016, In : American Journal of Tropical Medicine and Hygiene. 95, 3, p. 580-587 8 p.

Research output: Contribution to journalArticle

Merozoite Surface Protein 1
Plasmodium falciparum
Malaria
Genotype
Interferon-gamma
3 Citations (Scopus)

Long-term behavioral problems in children with severe malaria

Ssenkusu, J. M., Hodges, J. S., Opoka, R. O., Idro, R., Shapiro, E., John, C. & Bangirana, P., Nov 1 2016, In : Pediatrics. 138, 5, e20161965.

Research output: Contribution to journalArticle

Malaria
Cerebral Malaria
Anemia
Problem Behavior
Uganda
2 Citations (Scopus)

Malassezia Pneumonia: A Rare Complication of Parenteral Nutrition Therapy

Baker, R. M., Stegink, R. J., Manaloor, J. J., Schmitt, B., Stevens, J. & Christenson, J., Nov 1 2016, In : Journal of Parenteral and Enteral Nutrition. 40, 8, p. 1194-1196 3 p.

Research output: Contribution to journalArticle

Nutrition Therapy
Malassezia
Parenteral Nutrition
Pneumonia
Tinea Versicolor
2 Citations (Scopus)

Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: Results from a prospective cohort study and randomized double-blind placebo-controlled trial

Conroy, A. L., Hawkes, M., Hayford, K., Hermann, L., McDonald, C. R., Sharma, S., Namasopo, S., Opoka, R. O., John, C., Liles, W. C., Miller, C. & Kain, K. C., Nov 4 2016, In : BMC Pediatrics. 16, 1, 177.

Research output: Contribution to journalArticle

Methemoglobin
Hospitalized Child
Nitric Oxide
Cohort Studies
Fever
31 Citations (Scopus)

Perioperative management and outcomes of esophageal atresia and tracheoesophageal fistula

Lal, D. R., Gadepalli, S. K., Downard, C. D., Ostlie, D. J., Minneci, P. C., Swedler, R. M., Chelius, T., Cassidy, L., Rapp, C. T., Deans, K. J., Fallat, M. E., Finnell, S. M., Helmrath, M. A., Hirschl, R. B., Kabre, R. S., Leys, C. M., Mak, G., Raque, J., Rescorla, F., Saito, J. M. & 4 others, St. Peter, S. D., von Allmen, D., Warner, B. W. & Sato, T. T., Aug 15 2016, (Accepted/In press) In : Journal of Pediatric Surgery.

Research output: Contribution to journalArticle

Infant Care
Vocal Cord Paralysis
Demography
Heart Diseases
Morbidity
10 Citations (Scopus)

Perspective piece successful global health research partnerships: What makes them work?

John, C., Ayodo, G. & Musoke, P., Jan 1 2016, In : American Journal of Tropical Medicine and Hygiene. 94, 1, p. 5-7 3 p.

Research output: Contribution to journalArticle

Research
Uganda
Kenya
Global Health
Communication
12 Citations (Scopus)

Prophylactic antibiotics for prevention of cholangitis in patients with biliary atresia status post-kasai portoenterostomy: A systematic review

Decharun, K., Leys, C. M., West, K. W. & Finnell, S. M., Jan 1 2016, In : Clinical Pediatrics. 55, 1, p. 66-72 7 p.

Research output: Contribution to journalArticle

Biliary Atresia
Cholangitis
Anti-Bacterial Agents
Randomized Controlled Trials
Bibliographic Databases
17 Citations (Scopus)

Selecting measures for the neurodevelopmental assessment of children in low- and middle-income countries

Semrud-Clikeman, M., Romero, R. A. A., Prado, E. L., Shapiro, E. G., Bangirana, P. & John, C., Sep 10 2016, (Accepted/In press) In : Child Neuropsychology. p. 1-42 42 p.

Research output: Contribution to journalArticle

Research Personnel
Micronutrients
Psychometrics
Reproducibility of Results
Malnutrition
5 Citations (Scopus)

The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria

Shabani, E., Opoka, R. O., Bangirana, P., Park, G. S., Vercellotti, G. M., Guan, W., Hodges, J. S., Lavstsen, T. & John, C., Jun 3 2016, In : Scientific Reports. 6, 27084.

Research output: Contribution to journalArticle

Protein C
Malaria
Genotype
Communicable Diseases
Immunologic Factors