Pediatric Infectious Disease

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2020

Blackwater Fever in Ugandan Children With Severe Anemia is Associated With Poor Postdischarge Outcomes: A Prospective Cohort Study

Opoka, R. O., Waiswa, A., Harriet, N., John, C. C., Tumwine, J. K. & Karamagi, C., May 23 2020, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 70, 11, p. 2247-2254 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Central Nervous System Virus Infection in African Children with Cerebral Malaria

Postels, D. G., Osei-Tutu, L., Seydel, K. B., Xu, Q., Li, C., Taylor, T. E., John, C. C., Mallewa, M., Solomon, T., Agbenyega, T., Ansong, D., Opoka, R. O., Khan, L. M., Ramachandran, P. S., Leon, K. E., DeRisi, J. L., Langelier, C. & Wilson, M. R., Jul 1 2020, In : The American journal of tropical medicine and hygiene. 103, 1, p. 200-205 6 p.

Research output: Contribution to journalArticle

Comparison of Risk of Recrudescent Fever in Children With Kawasaki Disease Treated With Intravenous Immunoglobulin and Low-Dose vs High-Dose Aspirin

Platt, B., Belarski, E., Manaloor, J., Ofner, S., Carroll, A. E., John, C. C. & Wood, J. B., Jan 3 2020, In : JAMA Network Open. 3, 1, p. e1918565

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Delayed iron does not alter cognition or behavior among children with severe malaria and iron deficiency

Ssemata, A. S., Hickson, M., Ssenkusu, J. M., Cusick, S. E., Nakasujja, N., Opoka, R. O., Kroupina, M., Georgieff, M. K., Bangirana, P. & John, C. C., Sep 1 2020, In : Pediatric Research. 88, 3, p. 429-437 9 p.

Research output: Contribution to journalArticle

Delayed iron improves iron status without altering malaria risk in severe malarial anemia

Cusick, S. E., Opoka, R. O., Ssemata, A. S., Georgieff, M. K., John, C. C. & John, C. C., May 1 2020, In : American Journal of Clinical Nutrition. 111, 5, p. 1059-1067 9 p.

Research output: Contribution to journalArticle

Open Access

Malaria parasitemia among blood donors in Uganda

Murphy, K. J., Conroy, A. L., Ddungu, H., Shrestha, R., Kyeyune-Byabazaire, D., Petersen, M. R., Musisi, E., Patel, E. U., Kasirye, R., Bloch, E. M., Lubega, I., John, C. C., Hume, H. A. & Tobian, A. A. R., May 1 2020, In : Transfusion. 60, 5, p. 955-964 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Perceived benefits and risks of participation in a clinical trial for Ugandan children with sickle cell anemia

Carman, A. S., Sautter, C., Anyanwu, J. N., Ssemata, A. S., Opoka, R. O., Ware, R. E., Rujumba, J. & John, C. C., Feb 1 2020, In : Pediatric Blood and Cancer. 67, 2, e27830.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Acute kidney injury in Ugandan children with severe malaria is associated with long-term behavioral problems

Hickson, M. R., Conroy, A. L., Bangirana, P., Opoka, R. O., Idro, R., Ssenkusu, J. M. & John, C. C., Dec 2019, In : PloS one. 14, 12, e0226405.

Research output: Contribution to journalArticle

Open Access

Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria

Conroy, A. L., Opoka, R. O., Bangirana, P., Idro, R., Ssenkusu, J. M., Datta, D., Hodges, J. S., Morgan, C. & John, C. C., May 21 2019, In : BMC medicine. 17, 1, 98.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Adherence to clinical guidelines is associated with reduced inpatient mortality among children with severe anemia in Ugandan hospitals

Opoka, R. O., Ssemata, A. S., Oyang, W., Nambuya, H., John, C. C., Karamagi, C. & Tumwine, J. K., Jan 2019, In : PloS one. 14, 1, e0210982.

Research output: Contribution to journalArticle

3 Scopus citations

Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria

Rivera-Correa, J., Conroy, A. L., Opoka, R. O., Batte, A., Namazzi, R., Ouma, B., Bangirana, P., Idro, R., Schwaderer, A. L., John, C. C. & Rodriguez, A., Dec 1 2019, In : Scientific reports. 9, 1, 14940.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Caregivers and community perceptions of blood transfusion for children with severe anaemia in Uganda

Dhabangi, A., Idro, R., John, C. C., Dzik, W. H., Opoka, R., Siu, G. E., Ayebare, F. & van Hensbroek, M. B., Feb 1 2019, In : Transfusion Medicine. 29, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

Case report: Birth outcome and neurodevelopment in placental malaria discordant twins

Conroy, A. L., Bangirana, P., Muhindo, M. K., Kakuru, A., Jagannathan, P., Opoka, R. O., Liechty, E., Nakalembe, M., Kamya, M. R., Dorsey, G. & John, C. C., Jan 1 2019, In : American Journal of Tropical Medicine and Hygiene. 100, 3, p. 552-555 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Community perceptions of paediatric severe anaemia in Uganda

Dhabangi, A., Idro, R., John, C., Dzik, W. H., Siu, G. E., Opoka, R. O., Ayebare, F. & Van Hensbroek, M. B., Jan 1 2019, In : PLoS One. 14, 1, e0209476.

Research output: Contribution to journalArticle

Comparison of non-magnetic and magnetic beads multiplex assay for assessment of Plasmodium falciparum antibodies

Ondigo, B. N., Park, G. S., Ayieko, C., Nyangahu, D. D., Wasswa, R. & John, C. C., 2019, In : PeerJ. 2019, 1, e6120.

Research output: Contribution to journalArticle

HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya

Odhiambo, E. O., Datta, D., Guyah, B., Ayodo, G., Ondigo, B. N., Abong'O, B. O., John, C. C. & Frosch, A. E. P., Aug 30 2019, In : Malaria Journal. 18, 1, 297.

Research output: Contribution to journalArticle

Open Access

Patterns of traumatic brain injury and six-month neuropsychological outcomes in Uganda

Bangirana, P., Giordani, B., Kobusingye, O., Murungyi, L., Mock, C., John, C. C. & Idro, R., Feb 4 2019, In : BMC Neurology. 19, 1, 18.

Research output: Contribution to journalArticle

2 Scopus citations

Risk factors for recurrent severe anemia among previously transfused children in Uganda: An age-matched case-control study

Dhabangi, A., Idro, R., John, C. C., Dzik, W. H., Opoka, R., Ssenyonga, R. & Van Hensbroek, M. B., Jan 18 2019, In : BMC Pediatrics. 19, 1, 27.

Research output: Contribution to journalArticle

What causes severe malaria and its complications in children? Lessons learned over the past

Conroy, A. L., Datta, D. & John, C. C., Mar 7 2019, In : BMC medicine. 17, 1, 52.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Whole-blood transcriptional signatures composed of erythropoietic and NRF2-Regulated genes differ between cerebral malaria and severe malarial anemia

Nallandhighal, S., Park, G. S., Ho, Y. Y., Opoka, R. O., John, C. C. & Tran, T. M., Jan 1 2019, In : Journal of Infectious Diseases. 219, 1, p. 154-164 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Zinc for infection prevention in sickle cell anemia (zips): Study protocol for a randomized placebo-controlled trial in ugandan children with sickle cell anemia

Datta, D., Namazzi, R., Conroy, A. L., Cusick, S. E., Hume, H. A., Tagoola, A., Ware, R. E., Opoka, R. O. & John, C. C., Jul 26 2019, In : Trials. 20, 1, 460.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes

Postels, D. G., Wu, X., Li, C., Kaplan, P. W., Seydel, K. B., Taylor, T. E., Kousa, Y. A., Idro, R., Opoka, R., John, C. C. & Birbeck, G. L., May 22 2018, In : Malaria Journal. 17, 1, 208.

Research output: Contribution to journalArticle

5 Scopus citations

Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria NCT01255215 NCT

Conroy, A. L., Hawkes, M. T., Elphinstone, R., Opoka, R. O., Namasopo, S., Miller, C., John, C. C. & Kain, K. C., Feb 15 2018, In : Malaria Journal. 17, 1, 82.

Research output: Contribution to journalArticle

4 Scopus citations

High rate of inappropriate blood transfusions in the management of children with severe anemia in Ugandan hospitals

Opoka, R. O., Ssemata, A. S., Oyang, W., Nambuya, H., John, C. C., Tumwine, J. K. & Karamagi, C., Jul 18 2018, In : BMC Health Services Research. 18, 1, 566.

Research output: Contribution to journalArticle

4 Scopus citations

Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial

Bangirana, P., Conroy, A. L., Opoka, R. O., Hawkes, M. T., Hermann, L., Miller, C., Namasopo, S., Liles, W. C., John, C. C. & Kain, K. C., Jan 2018, In : PloS one. 13, 1, e0191550.

Research output: Contribution to journalArticle

7 Scopus citations

Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia

Opoka, R. O., Bangirana, P., Idro, R., Shabani, E., Namazzi, R. & John, C. C., Jan 2018, In : Pediatric Blood and Cancer. 65, 1, e26745.

Research output: Contribution to journalArticle

3 Scopus citations

Malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less than 5 years in Uganda and Kenya: Study protocol for a multi-centre, two-arm, randomised, placebo-controlled, superiority trial

Kwambai, T. K., Dhabangi, A., Idro, R., Opoka, R., Kariuki, S., Samuels, A. M., Desai, M., Van Hensbroek, M. B., John, C. C., Robberstad, B., Wang, D., Phiri, K. & Ter Kuile, F. O., Nov 6 2018, In : Trials. 19, 1, 610.

Research output: Contribution to journalArticle

4 Scopus citations

Sharing antimicrobial reports for pediatric stewardship (SHARPS): A quality improvement collaborative

SHARPS Collaborative, 2018, In : Journal of the Pediatric Infectious Diseases Society. 7, 2, p. 124-128 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa

Taylor, W. R., Naw, H. K., Maitland, K., Williams, T. N., Kapulu, M., D'Alessandro, U., Berkley, J. A., Bejon, P., Okebe, J., Achan, J., Amambua, A. N., Affara, M., Nwakanma, D., van Geertruyden, J. P., Mavoko, M., Lutumba, P., Matangila, J., Brasseur, P., Piola, P., Randremanana, R. & 24 others, Lasry, E., Fanello, C., Onyamboko, M., Schramm, B., Yah, Z., Jones, J., Fairhurst, R. M., Diakite, M., Malenga, G., Molyneux, M., Rwagacondo, C., Obonyo, C., Gadisa, E., Aseffa, A., Loolpapit, M., Henry, M. C., Dorsey, G., John, C., Sirima, S. B., Barnes, K. I., Kremsner, P., Day, N. P., White, N. J. & Mukaka, M., Jan 18 2018, In : BMC medicine. 16, 1, 11.

Research output: Contribution to journalArticle

1 Scopus citations
2017

A step toward high reliability: Implementation of a daily safety brief in a Children's Hospital

Saysana, M., Mccaskey, M., Cox, E., Thompson, R., Tuttle, L. K. & Haut, P. R., Sep 1 2017, In : Journal of Patient Safety. 13, 3, p. 149-152 4 p.

Research output: Contribution to journalArticle

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Holmberg, D., Franzén-Röhl, E., Idro, R., Opoka, R. O., Bangirana, P., Sellgren, C. M., Wickström, R., Färnert, A., Schwieler, L., Engberg, G. & John, C. C., Jul 28 2017, In : Malaria Journal. 16, 1, 303.

Research output: Contribution to journalArticle

10 Scopus citations

Clinical comparison of retinopathy-positive and retinopathy-negative cerebral Malaria

Villaverde, C., Namazzi, R., Shabani, E., Opoka, R. O. & John, C., 2017, In : American Journal of Tropical Medicine and Hygiene. 96, 5, p. 1176-1184 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Decrease in numbers of naive and resting B cells in HIV-infected Kenyan Adults leads to a proportional increase in total and plasmodium falciparum-specific atypical memory B cells

Frosch, A. E., Odumade, O. A., Taylor, J. J., Ireland, K., Ayodo, G., Ondigo, B., Narum, D. L., Vulule, J. & John, C. C., Jun 15 2017, In : Journal of Immunology. 198, 12, p. 4629-4638 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiency

Jaramillo, E. G., Mupere, E., Opoka, R. O., Hodges, J. S., Lund, T. C., Georgieff, M. K., John, C. C. & Cusick, S. E., Aug 2017, In : PloS one. 12, 8, e0183977.

Research output: Contribution to journalArticle

2 Scopus citations
9 Scopus citations

Effect of transmission intensity on hotspots and micro-epidemiology of malaria in sub-Saharan Africa

on behalf of The Hotspot Group Authors, Jun 30 2017, In : BMC medicine. 15, 1, 121.

Research output: Contribution to journalArticle

13 Scopus citations

Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria

Shabani, E., Ouma, B. J., Idro, R., Bangirana, P., Opoka, R. O., Park, G. S., Conroy, A. L. & John, C. C., Jul 2017, In : Parasite Immunology. 39, 7, e12438.

Research output: Contribution to journalArticle

12 Scopus citations

Impact of a national guideline on antibiotic selection for hospitalized pneumonia

Pediatric Research in Inpatient Settings Network, Apr 2017, In : Pediatrics. 139, 4, e20163231.

Research output: Contribution to journalArticle

7 Scopus citations

Interferon- γ responses to Plasmodium falciparum vaccine candidate antigens decrease in the absence of malaria transmission

Ayieko, C., Ogola, B. S., Ochola, L., Ngwena, G. A. M., Ayodo, G., Hodges, J. S., Noland, G. S. & John, C. C., 2017, In : PeerJ. 2017, 1, e2855.

Research output: Contribution to journalArticle

2 Scopus citations

Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia

Opoka, R. O., Ndugwa, C. M., Latham, T. S., Lane, A., Hume, H. A., Kasirye, P., Hodges, J. S., Ware, R. E. & John, C. C., Dec 14 2017, In : Blood. 130, 24, p. 2585-2593 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Perioperative management and outcomes of esophageal atresia and tracheoesophageal fistula

Lal, D. R., Gadepalli, S. K., Downard, C. D., Ostlie, D. J., Minneci, P. C., Swedler, R. M., Chelius, T., Cassidy, L., Rapp, C. T., Deans, K. J., Fallat, M. E., Finnell, S. M. E., Helmrath, M. A., Hirschl, R. B., Kabre, R. S., Leys, C. M., Mak, G., Raque, J., Rescorla, F. J., Saito, J. M. & 4 others, St. Peter, S. D., von Allmen, D., Warner, B. W. & Sato, T. T., Aug 2017, In : Journal of pediatric surgery. 52, 8, p. 1245-1251 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria

Shabani, E., Hanisch, B., Opoka, R. O., Lavstsen, T. & John, C. C., Oct 13 2017, In : BMC medicine. 15, 1, 183.

Research output: Contribution to journalArticle

14 Scopus citations

Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya

Weber, G. E., White, M. T., Babakhanyan, A., Sumba, P. O., Vulule, J., Ely, D., John, C., Angov, E., Lanar, D., Dutta, S., Narum, D. L., Horii, T., Cowman, A., Beeson, J., Smith, J., Kazura, J. W. & Dent, A. E., Dec 1 2017, In : Scientific reports. 7, 1, 16821.

Research output: Contribution to journalArticle

1 Scopus citations

Supporting global health at the pediatric department level: Why and how

Pitt, M. B., Moore, M. A., John, C. C., Batra, M., Butteris, S. M., Airewele, G. E., Suchdev, P. S. & Steinhoff, M. C., Jun 2017, In : Pediatrics. 139, 6, e20163939.

Research output: Contribution to journalArticle

11 Scopus citations

The Benjamin H. Kean travel fellowship in tropical medicine: Assessment of impact at 15 years

Carman, A. S. & John, C. C., 2017, In : American Journal of Tropical Medicine and Hygiene. 97, 3, p. 958-963 6 p.

Research output: Contribution to journalArticle

2016

Acute kidney injury is common in pediatric severe malaria and is associated with increased mortality

Conroy, A. L., Hawkes, M., Elphinstone, R. E., Morgan, C., Hermann, L., Barker, K. R., Namasopo, S., Opoka, R. O., John, C. C., Liles, W. C. & Kain, K. C., Apr 1 2016, In : Open Forum Infectious Diseases. 3, 2

Research output: Contribution to journalArticle

30 Scopus citations

Alterations in Systemic Extracellular Heme and Hemopexin Are Associated with Adverse Clinical Outcomes in Ugandan Children with Severe Malaria

Elphinstone, R. E., Conroy, A. L., Hawkes, M., Hermann, L., Namasopo, S., Warren, H. S., John, C. C., Liles, W. C. & Kain, K. C., Oct 15 2016, In : Journal of Infectious Diseases. 214, 8, p. 1268-1275 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

An Evaluation of Various Ventilator-Associated Infection Criteria in a PICU

Beardsley, A. L., Nitu, M., Cox, E. & Benneyworth, B. D., Jan 1 2016, In : Pediatric Critical Care Medicine. 17, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Cerebral malaria is associated with long-term mental health disorders: A cross sectional survey of a long-term cohort

Idro, R., Kakooza-Mwesige, A., Asea, B., Ssebyala, K., Bangirana, P., Opoka, R. O., Lubowa, S. K., Semrud-Clikeman, M., John, C. C. & Nalugya, J., Mar 31 2016, In : Malaria Journal. 15, 1, 184.

Research output: Contribution to journalArticle

27 Scopus citations