Ahmad Safa

  • 5616 Citations
  • 42 h-Index
1981 …2018
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Publications 1981 2018

  • 5616 Citations
  • 42 h-Index
  • 120 Article
  • 1 Chapter
  • 1 Review article
2018
1 Citation (Scopus)

A Dose-escalation Study of Recombinant Human Interleukin-18 in Combination with Ofatumumab after Autologous Peripheral Blood Stem Cell Transplantation for Lymphoma

Robertson, M., Stamatkin, C. W., Pelloso, D., Weisenbach, J., Prasad, N. K. & Safa, A., Jan 1 2018, In : Journal of Immunotherapy. 41, 3, p. 151-157 7 p.

Research output: Contribution to journalArticle

Peripheral Blood Stem Cell Transplantation
Interleukin-18
Lymphoma
Intravenous Infusions
Natural Killer Cells
2017
8 Citations (Scopus)

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z-Y. & Lu, T., 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Pancreatic Neoplasms
Colorectal Neoplasms
Adenocarcinoma
Neoplasms
3 Citations (Scopus)

Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases

Prabhu, L., Chen, L., Wei, H., Demir, Ö., Safa, A., Zeng, L., Amaro, R. E., O'Neil, B. H., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Molecular BioSystems. 13, 12, p. 2509-2520 12 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Histones
Methylation
Arginine
Streptavidin
5 Citations (Scopus)

Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Wang, H., Nguyen, A., Kamocka, M., Cai, W., Cohen-Gadol, A., Halum, S. L., Sarkaria, J. N., Pollok, K. & Safa, A., Dec 1 2017, In : Journal of Neurosurgery. 127, 6, p. 1219-1230 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
Stem Cells
Growth
Neoplasms
2016
19 Citations (Scopus)

Emerging targets for glioblastoma stem cell therapy

Safa, A., Saadatzadeh, M. R., Cohen-Gadol, A., Pollok, K. & Bijangi-Vishehsaraei, K., 2016, In : Journal of Biomedical Research. 30, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell- and Tissue-Based Therapy
Stem cells
Stem Cells
Tumors
2 Citations (Scopus)

Microarray analysis gene expression profiles in laryngeal muscle after recurrent laryngeal nerve injury

Bijangi-Vishehsaraei, K., Blum, K., Zhang, H., Safa, A. & Halum, S. L., Mar 1 2016, In : Annals of Otology, Rhinology and Laryngology. 125, 3, p. 247-256 10 p.

Research output: Contribution to journalArticle

Recurrent Laryngeal Nerve Injuries
Laryngeal Muscles
Microarray Analysis
Transcriptome
Wallerian Degeneration
40 Citations (Scopus)

Resistance to cell death and its modulation in cancer stem cells

Safa, A., 2016, In : Critical Reviews in Oncogenesis. 21, 3-4, p. 203-219 17 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Cell Death
Neoplasms
Therapeutics
Radiotherapy
2015
69 Citations (Scopus)

Glioblastoma stem cells (GSCs) epigenetic plasticity and interconversion between differentiated non-GSCs and GSCs

Safa, A., Saadatzadeh, M. R., Cohen-Gadol, A., Pollok, K. & Bijangi-Vishehsaraei, K., Jun 1 2015, In : Genes and Diseases. 2, 2, p. 152-163 12 p.

Research output: Contribution to journalReview article

Glioblastoma
Stem cells
Epigenomics
Plasticity
Stem Cells
12 Citations (Scopus)

Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model

Tonsing-Carter, E., Bailey, B. J., Saadatzadeh, M. R., Ding, J., Wang, H., Sinn, A. L., Peterman, K. M., Spragins, T. K., Silver, J. M., Sprouse, A. A., Georgiadis, T. M., Gunter, T. Z., Long, E. C., Minto, R. E., Marchal, C. C., Batuello, C. N., Safa, A., Hanenberg, H., Territo, P., Sandusky, G. & 4 others, Mayo, L., Eischen, C. M., Shannon, H. E. & Pollok, K., Dec 1 2015, In : Molecular Cancer Therapeutics. 14, 12, p. 2850-2863 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Carboplatin
DNA Damage
Breast
Lung
2012
150 Citations (Scopus)

c-FLIP, a master anti-apoptotic regulator

Safa, A., Sep 2012, In : Experimental Oncology. 34, 3, p. 176-184 9 p.

Research output: Contribution to journalArticle

Apoptosis
Death Domain Receptor Signaling Adaptor Proteins
Neoplasms
Tumor Necrosis Factor-alpha
Effector Caspases
2011
93 Citations (Scopus)

Targeting the anti-apoptotic protein c-FLIP for cancer therapy

Safa, A. & Pollok, K., Jun 2011, In : Cancers. 3, 2, p. 1639-1671 33 p.

Research output: Contribution to journalArticle

Apoptosis Regulatory Proteins
Apoptosis
Death Domain Receptor Signaling Adaptor Proteins
TNF-Related Apoptosis-Inducing Ligand
Neoplasms
2010
17 Citations (Scopus)

4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Huang, S., Murphy, M. & Safa, A., Sep 2010, In : Molecular and Cellular Biochemistry. 342, 1-2, p. 133-142 10 p.

Research output: Contribution to journalArticle

Caspase 10
Cells
Apoptosis
Breast Neoplasms
Messenger RNA
16 Citations (Scopus)
Bearings (structural)
TNF-Related Apoptosis-Inducing Ligand Receptors
P-Glycoprotein
Leukemia
Apoptosis
2009
13 Citations (Scopus)

C-FLIP gene silencing eliminates tumor cells in breast cancer xenografts without affecting stromal cells

Day, T. W., Sinn, A. L., Huang, S., Pollok, K., Sandusky, G. & Safa, A., Oct 2009, In : Anticancer Research. 29, 10, p. 3883-3886 4 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Gene Silencing
Stromal Cells
Heterografts
Breast Neoplasms
28 Citations (Scopus)

Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells

Shen, F., Bailey, B. J., Chu, S., Bence, A. K., Xue, X., Erickson, P., Safa, A., Beck, W. T. & Erickson, L. C., Aug 2009, In : Journal of Pharmacology and Experimental Therapeutics. 330, 2, p. 423-429 7 p.

Research output: Contribution to journalArticle

Mitoxantrone
Multiple Drug Resistance
P-Glycoprotein
Neoplasms
valspodar
23 Citations (Scopus)

Etoposide induces protein kinase Cδ- and caspase-3-dependent apoptosis in neuroblastoma cancer cells

Day, T. W., Wu, C. H. & Safa, A., Sep 2009, In : Molecular Pharmacology. 76, 3, p. 632-640 9 p.

Research output: Contribution to journalArticle

Etoposide
Neuroblastoma
Caspase 3
Protein Kinase C
Caspase 8
17 Citations (Scopus)
beta-galactoside alpha-2,3-sialyltransferase
Sialyltransferases
Galactosides
Caspase 8
Paclitaxel
15 Citations (Scopus)

RNA interference in cancer: Targeting the anti-apoptotic protein c-FLIP for drug discovery

Day, T. W. & Safa, A., 2009, In : Mini-Reviews in Medicinal Chemistry. 9, 6, p. 741-748 8 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Apoptosis Regulatory Proteins
Drug Discovery
RNA Interference
Gene Silencing
6 Citations (Scopus)

The Xpc gene markedly affects cell survival in mouse bone marrow

Fischer, J. L., Kumar, M. A. S., Day, T. W., Hardy, T. M., Hamilton, S., Besch-Williford, C., Safa, A., Pollok, K. & Smith, M. L., Jul 2009, In : Mutagenesis. 24, 4, p. 309-316 8 p.

Research output: Contribution to journalArticle

Cell Survival
Bone
Repair
DNA Repair
Nucleotides
2008
8 Citations (Scopus)

Analysis of changes in the proteome of HL-60 promyeloid leukemia cells induced by the proteasome inhibitor PSI

Choi, M. R., Najafi, F., Safa, A. & Drexler, H. C. A., Jun 15 2008, In : Biochemical Pharmacology. 75, 12, p. 2276-2288 13 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Proteome
Leukemia
HL-60 Cells
Cells
134 Citations (Scopus)

Cellular FLICE-like inhibitory protein (C-FLIP): A novel target for cancer therapy

Safa, A., Day, T. W. & Wu, C. H., Feb 2008, In : Current Cancer Drug Targets. 8, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Staphylococcal Protein A
Neoplasms
Death Domain Receptor Signaling Adaptor Proteins
Caspase 8
57 Citations (Scopus)

c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells

Day, T. W., Huang, S. & Safa, A., Dec 15 2008, In : Biochemical Pharmacology. 76, 12, p. 1694-1704 11 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Caspase 9
Caspase 8
MCF-7 Cells
Cells
6 Citations (Scopus)
Death Domain Receptors
HL-60 Cells
Adenoviridae
Apoptosis
Acute Myeloid Leukemia
2007
11 Citations (Scopus)
DNA-Activated Protein Kinase
RNA Helicases
Phosphorylation
Multiple Drug Resistance
P-Glycoprotein
2006
48 Citations (Scopus)

Cellular FLICE-like inhibitory protein (c-FLIP): A novel target for Taxol-induced apoptosis

Day, T. W., Najafi, F., Wu, C. H. & Safa, A., May 28 2006, In : Biochemical Pharmacology. 71, 11, p. 1551-1561 11 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Staphylococcal Protein A
Paclitaxel
Protein S
Apoptosis
26 Citations (Scopus)

P-glycoprotein enhances TRAIL-triggered apoptosis in multidrug resistant cancer cells by interacting with the death receptor DR5

Park, S. J., Wu, C. H., Choi, M. R., Najafi, F., Emami, A. & Safa, A., Jul 28 2006, In : Biochemical Pharmacology. 72, 3, p. 293-307 15 p.

Research output: Contribution to journalArticle

Death Domain Receptors
P-Glycoprotein
Cells
Apoptosis
Neoplasms
2004
21 Citations (Scopus)
Caspase 6
Caspase 7
P-Glycoprotein
Doxorubicin
Breast Neoplasms
76 Citations (Scopus)
Multiple Drug Resistance
P-Glycoprotein
Binding Sites
Pharmaceutical Preparations
Carrier Proteins
31 Citations (Scopus)

RNA Helicase A in the MEF1 Transcription Factor Complex Up-regulates the MDR1 Gene in Multidrug-resistant Cancer Cells

Zhong, X. & Safa, A., Apr 23 2004, In : Journal of Biological Chemistry. 279, 17, p. 17134-17141 8 p.

Research output: Contribution to journalArticle

RNA Helicases
Transcription Factors
Up-Regulation
Genes
Cells
169 Citations (Scopus)

Taxol induces caspase-10-dependent apoptosis

Park, S. J., Wu, C. H., Gordon, J. D., Zhong, X., Emami, A. & Safa, A., Dec 3 2004, In : Journal of Biological Chemistry. 279, 49, p. 51057-51067 11 p.

Research output: Contribution to journalArticle

Caspase 10
Paclitaxel
Apoptosis
Death Domain Receptors
Caspase 8
2003
28 Citations (Scopus)
Caspase 8
Caspases
Caspase 3
Reactive Oxygen Species
Leukemia
2002
10 Citations (Scopus)

Irinotecan and gemcitabine in patients with solid tumors: phase I trial.

Lima, C. M. S. R., Leong, S. S., Sherman, C. A., Perkel, J. A., Putman, T., Safa, A. & Green, M. R., May 2002, In : Oncology (Williston Park, N.Y.). 16, 5 Suppl 5

Research output: Contribution to journalArticle

irinotecan
gemcitabine
Maximum Tolerated Dose
Neoplasms
Diarrhea
6 Citations (Scopus)

Mechanism of β2- microglobulin-induced apoptosis in the K562 leukemia cell line, defective in major histocompatibility class 1

Wu, C. H., Gordon, J. D., Zhong, X. & Safa, A., Sep 2002, In : Anticancer Research. 22, 5, p. 2613-2621 9 p.

Research output: Contribution to journalArticle

Histocompatibility
K562 Cells
Leukemia
Apoptosis
Cell Line
14 Citations (Scopus)

Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant

Wu, C. H., Gordon, J., Rastegar, M., Ogretmen, B. & Safa, A., Aug 1 2002, In : Oncogene. 21, 33, p. 5160-5174 15 p.

Research output: Contribution to journalArticle

Myeloblastin
HL-60 Cells
Serine Proteases
Doxorubicin
Leukemia
2001
23 Citations (Scopus)

β2-microglobulin induces apoptosis in HL-60 human leukemia cell line and its multidrug resistant variants overexpressing MRP1 but lacking Bax or overexpressing P-glycoprotein

Wu, C. H., Rastegar, M., Gordon, J. & Safa, A., Oct 25 2001, In : Oncogene. 20, 48, p. 7006-7020 15 p.

Research output: Contribution to journalArticle

HL-60 Cells
P-Glycoprotein
Leukemia
Apoptosis
Cell Line
46 Citations (Scopus)
Videocassette recorders
HL-60 Cells
Myeloid Cells
Acute Myeloid Leukemia
Luciferases
18 Citations (Scopus)
Multidrug Resistance-Associated Proteins
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Messenger RNA
Acute Myeloid Leukemia
Biphenotypic Acute Leukemia
4 Citations (Scopus)

Irinotecan in the management of patients with pancreatic cancer

Green, M. R., Harper, M., Safa, A., Sherman, C. A., Mushtaq, C. M., Bahadori, H., Brescia, F. J. & Rocha Lima, C. M. S. P., 2000, In : Oncology (Williston Park, N.Y.). 14, 12 SUPPL. 14, p. 31-33 3 p.

Research output: Contribution to journalArticle

irinotecan
gemcitabine
Pancreatic Neoplasms
Multicenter Studies
1999
81 Citations (Scopus)
MCF-7 Cells
Electrophoretic mobility
Transcription Factors
Luciferases
Messenger RNA
9 Citations (Scopus)
Multiple Drug Resistance
P-Glycoprotein
Binding Sites
P-Glycoproteins
Pharmaceutical Preparations
16 Citations (Scopus)

Single-agent gemcitabine and gemcitabine/irinotecan combination (IrimoGem) in non-small cell lung cancer

Rocha Lima, C. M. S., Eckardt, J. R., Leong, S. S., Sherman, C. A., Perkel, J. A., Putman, T., Safa, A., Bahadori, H. R. & Green, M. R., 1999, In : Seminars in Oncology. 26, 5 SUPPL. 16, p. 43-50 8 p.

Research output: Contribution to journalArticle

irinotecan
gemcitabine
Non-Small Cell Lung Carcinoma
Type I DNA Topoisomerase
Pancreatic Neoplasms
43 Citations (Scopus)

Synergistic effect of gemcitabine and irinotecan (CPT-11) on breast and small cell lung cancer cell lines

Bahadori, H. R., Rocha Lima, C. M. S., Green, M. R. & Safa, A., Nov 1999, In : Anticancer Research. 19, 6 B, p. 5423-5428 6 p.

Research output: Contribution to journalArticle

irinotecan
gemcitabine
Small Cell Lung Carcinoma
Breast
Cell Line
1998
30 Citations (Scopus)

Cell-specific modulation of drug resistance in acute myeloid leukemic blasts by diphtheria fusion toxin, DT388-GMCSF

Frankel, A. E., Hall, P. D., McLain, C., Safa, A., Tagge, E. P. & Kreitman, R. J., Jul 1998, In : Bioconjugate Chemistry. 9, 4, p. 490-496 7 p.

Research output: Contribution to journalArticle

Diphtheria Toxin
Drug Resistance
Doxorubicin
Fusion reactions
Modulation
32 Citations (Scopus)

Co-ordinated over-expression of the MRP and γ-glutamylcysteine synthetase genes, but not MDR1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines

Ogretmen, B., Bahadori, H. R., Mccauley, M. D., Boylan, A., Green, M. R. & Safa, A., Mar 2 1998, In : International Journal of Cancer. 75, 5, p. 757-761 5 p.

Research output: Contribution to journalArticle

Glutamate-Cysteine Ligase
Multidrug Resistance-Associated Proteins
Mesothelioma
Doxorubicin
Cell Line
54 Citations (Scopus)

Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents

Dolan, M. E., Frydman, B., Thompson, C. B., Diamond, A. M., Garbiras, B. J., Safa, A., Beck, W. T. & Marton, L. J., 1998, In : Anti-Cancer Drugs. 9, 5, p. 437-448 12 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Naphthoquinones
Growth
P-Glycoprotein
Neoplasms
4 Citations (Scopus)
Glutamate-Cysteine Ligase
Multidrug Resistance-Associated Proteins
Polyomavirus Transforming Antigens
Viral Tumor Antigens
Doxorubicin
28 Citations (Scopus)

Molecular mechanisms of loss of β2-microglobulin expression in drug- resistant breast cancer sublines and its involvement in drug resistance

Ogretmen, B., McCauley, M. D. & Safa, A., Aug 18 1998, In : Biochemistry. 37, 33, p. 11679-11691 13 p.

Research output: Contribution to journalArticle

Drug Resistance
Doxorubicin
MCF-7 Cells
Breast Neoplasms
Pharmaceutical Preparations
42 Citations (Scopus)

Photoaffinity labels for characterizing drug interaction sites of P- glycoprotein

Safa, A., 1998, In : Methods in Enzymology. 292, p. 289-307 19 p.

Research output: Contribution to journalArticle

Photoaffinity Labels
Drug interactions
P-Glycoprotein
1997
67 Citations (Scopus)

Circumvention of P-GP MDR as a function of anthracycline lipophilicity and charge

Lampidis, T. J., Kolonias, D., Podona, T., Israel, M., Safa, A., Lothstein, L., Savaraj, N., Tapiero, H. & Priebe, W., Mar 4 1997, In : Biochemistry. 36, 9, p. 2679-2685 7 p.

Research output: Contribution to journalArticle

Anthracyclines
Mitochondria
Doxorubicin
Modulators
Cytoplasm