Ahmad Safa

  • 5695 Citations
  • 42 h-Index
1981 …2020

Research output per year

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Publications

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2020

Regulation of a PRMT5/NF-κB axis by phosphorylation of PRMT5 at serine 15 in colorectal cancer

Hartley, A. V., Wang, B., Jiang, G., Wei, H., Sun, M., Prabhu, L., Martin, M., Safa, A., Sun, S., Liu, Y. & Lu, T., May 2 2020, In : International journal of molecular sciences. 21, 10, 3684.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

A Dose-escalation Study of Recombinant Human Interleukin-18 in Combination with Ofatumumab after Autologous Peripheral Blood Stem Cell Transplantation for Lymphoma

Robertson, M. J., Stamatkin, C. W., Pelloso, D., Weisenbach, J., Prasad, N. K. & Safa, A. R., Jan 1 2018, In : Journal of Immunotherapy. 41, 3, p. 151-157 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases

Prabhu, L., Chen, L., Wei, H., Demir, Ö., Safa, A., Zeng, L., Amaro, R. E., O'Neil, B. H., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Molecular BioSystems. 13, 12, p. 2509-2520 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Wang, H., Nguyen, A., Kamocka, M. M., Cai, W., Cohen-Gadol, A. A., Halum, S. L., Sarkaria, J. N., Pollok, K. E. & Safa, A. R., Dec 2017, In : Journal of neurosurgery. 127, 6, p. 1219-1230 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Microarray analysis gene expression profiles in laryngeal muscle after recurrent laryngeal nerve injury

Bijangi-Vishehsaraei, K., Blum, K., Zhang, H., Safa, A. R. & Halum, S. L., Mar 2016, In : Annals of Otology, Rhinology and Laryngology. 125, 3, p. 247-256 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Resistance to cell death and its modulation in cancer stem cells

Safa, A. R., 2016, In : Critical Reviews in Oncogenesis. 21, 3-4, p. 203-219 17 p.

Research output: Contribution to journalArticle

42 Scopus citations
2015

Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model

Tonsing-Carter, E., Bailey, B. J., Saadatzadeh, M. R., Ding, J., Wang, H., Sinn, A. L., Peterman, K. M., Spragins, T. K., Silver, J. M., Sprouse, A. A., Georgiadis, T. M., Gunter, T. Z., Long, E. C., Minto, R. E., Marchal, C. C., Batuello, C. N., Safa, A. R., Hanenberg, H., Territo, P. R., Sandusky, G. E. & 4 others, Mayo, L. D., Eischen, C. M., Shannon, H. E. & Pollok, K. E., Dec 1 2015, In : Molecular cancer therapeutics. 14, 12, p. 2850-2863 14 p.

Research output: Contribution to journalArticle

14 Scopus citations
2010

4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Huang, S., Murphy, M. P. & Safa, A. R., Sep 1 2010, In : Molecular and Cellular Biochemistry. 342, 1-2, p. 133-142 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
17 Scopus citations
2009

C-FLIP gene silencing eliminates tumor cells in breast cancer xenografts without affecting stromal cells

Day, T. W., Sinn, A. L., Huang, S., Pollok, K. E., Sandusky, G. E. & Safa, A. R., Oct 1 2009, In : Anticancer Research. 29, 10, p. 3883-3886 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells

Shen, F., Bailey, B. J., Chu, S., Bence, A. K., Xue, X., Erickson, P., Safa, A. R., Beck, W. T. & Erickson, L. C., Aug 2009, In : Journal of Pharmacology and Experimental Therapeutics. 330, 2, p. 423-429 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Etoposide induces protein kinase Cδ- and caspase-3-dependent apoptosis in neuroblastoma cancer cells

Day, T. W., Wu, C. H. & Safa, A. R., Sep 1 2009, In : Molecular pharmacology. 76, 3, p. 632-640 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
18 Scopus citations

RNA interference in cancer: Targeting the anti-apoptotic protein c-FLIP for drug discovery

Day, T. W. & Safa, A. R., Sep 21 2009, In : Mini-Reviews in Medicinal Chemistry. 9, 6, p. 741-748 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

The Xpc gene markedly affects cell survival in mouse bone marrow

Fischer, J. L., Kumar, M. A. S., Day, T. W., Hardy, T. M., Hamilton, S., Besch-Williford, C., Safa, A. R., Pollok, K. E. & Smith, M. L., Jul 2009, In : Mutagenesis. 24, 4, p. 309-316 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2008

Analysis of changes in the proteome of HL-60 promyeloid leukemia cells induced by the proteasome inhibitor PSI

Choi, M. R., Najafi, F., Safa, A. R. & Drexler, H. C. A., Jun 15 2008, In : Biochemical Pharmacology. 75, 12, p. 2276-2288 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells

Day, T. W., Huang, S. & Safa, A. R., Dec 15 2008, In : Biochemical Pharmacology. 76, 12, p. 1694-1704 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

TRAIL recombinant adenovirus triggers robust apoptosis in multidrug-resistant HL-60/Vinc cells preferentially through death receptor DR5

Wu, C. H., Kao, C. H. & Safa, A. R., Jul 1 2008, In : Human gene therapy. 19, 7, p. 731-743 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2007
12 Scopus citations
2006

Cellular FLICE-like inhibitory protein (c-FLIP): A novel target for Taxol-induced apoptosis

Day, T. W., Najafi, F., Wu, C. H. & Safa, A. R., May 28 2006, In : Biochemical Pharmacology. 71, 11, p. 1551-1561 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

P-glycoprotein enhances TRAIL-triggered apoptosis in multidrug resistant cancer cells by interacting with the death receptor DR5

Park, S. J., Wu, C. H., Choi, M. R., Najafi, F., Emami, A. & Safa, A. R., Jul 28 2006, In : Biochemical Pharmacology. 72, 3, p. 293-307 15 p.

Research output: Contribution to journalArticle

25 Scopus citations
2004
21 Scopus citations

RNA Helicase A in the MEF1 Transcription Factor Complex Up-regulates the MDR1 Gene in Multidrug-resistant Cancer Cells

Zhong, X. & Safa, A. R., Apr 23 2004, In : Journal of Biological Chemistry. 279, 17, p. 17134-17141 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Taxol induces caspase-10-dependent apoptosis

Park, S. J., Wu, C. H., Gordon, J. D., Zhong, X., Emami, A. & Safa, A. R., Dec 3 2004, In : Journal of Biological Chemistry. 279, 49, p. 51057-51067 11 p.

Research output: Contribution to journalArticle

170 Scopus citations
2003
28 Scopus citations
2002

Irinotecan and gemcitabine in patients with solid tumors: phase I trial.

Rocha Lima, C. M., Leong, S. S., Sherman, C. A., Perkel, J. A., Putman, T., Safa, A. R. & Green, M. R., May 2002, In : Oncology (Williston Park, N.Y.). 16, 5 Suppl 5, p. 19-24 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mechanism of β2- microglobulin-induced apoptosis in the K562 leukemia cell line, defective in major histocompatibility class 1

Wu, C. H., Gordon, J. D., Zhong, X. & Safa, A. R., Sep 1 2002, In : Anticancer Research. 22, 5, p. 2613-2621 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant

Wu, C. H., Gordon, J., Rastegar, M., Ogretmen, B. & Safa, A. R., Jan 1 2002, In : Oncogene. 21, 33, p. 5160-5174 15 p.

Research output: Contribution to journalArticle

15 Scopus citations
2001

β2-microglobulin induces apoptosis in HL-60 human leukemia cell line and its multidrug resistant variants overexpressing MRP1 but lacking Bax or overexpressing P-glycoprotein

Wu, C. H., Rastegar, M., Gordon, J. & Safa, A. R., Oct 25 2001, In : Oncogene. 20, 48, p. 7006-7020 15 p.

Research output: Contribution to journalArticle

24 Scopus citations
2000
46 Scopus citations
18 Scopus citations

Irinotecan in the management of patients with pancreatic cancer

Green, M. R., Harper, M., Safa, A., Sherman, C. A., Mushtaq, C. M., Bahadori, H., Brescia, F. J. & Rocha Lima, C. M. S. P., Dec 1 2000, In : ONCOLOGY. 14, 12 SUPPL. 14, p. 31-33 3 p.

Research output: Contribution to journalArticle

4 Scopus citations
1999
83 Scopus citations
9 Scopus citations

Single-agent gemcitabine and gemcitabine/irinotecan combination (IrimoGem) in non-small cell lung cancer

Rocha Lima, C. M. S., Eckardt, J. R., Leong, S. S., Sherman, C. A., Perkel, J. A., Putman, T., Safa, A. R., Bahadori, H. R. & Green, M. R., Dec 14 1999, In : Seminars in oncology. 26, 5 SUPPL. 16, p. 43-50 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Synergistic effect of gemcitabine and irinotecan (CPT-11) on breast and small cell lung cancer cell lines

Bahadori, H. R., Rocha Lima, C. M. S., Green, M. R. & Safa, A. R., Nov 1 1999, In : Anticancer Research. 19, 6 B, p. 5423-5428 6 p.

Research output: Contribution to journalArticle

43 Scopus citations
1998

Cell-specific modulation of drug resistance in acute myeloid leukemic blasts by diphtheria fusion toxin, DT388-GMCSF

Frankel, A. E., Hall, P. D., McLain, C., Safa, A. R., Tagge, E. P. & Kreitman, R. J., Jul 1 1998, In : Bioconjugate Chemistry. 9, 4, p. 490-496 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Co-ordinated over-expression of the MRP and γ-glutamylcysteine synthetase genes, but not MDR1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines

Ogretmen, B., Bahadori, H. R., Mccauley, M. D., Boylan, A., Green, M. R. & Safa, A. R., Mar 2 1998, In : International Journal of Cancer. 75, 5, p. 757-761 5 p.

Research output: Contribution to journalArticle

32 Scopus citations

Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents

Dolan, M. E., Frydman, B., Thompson, C. B., Diamond, A. M., Garbiras, B. J., Safa, A. R., Beck, W. T. & Marton, L. J., Jun 25 1998, In : Anti-Cancer Drugs. 9, 5, p. 437-448 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Lack of correlation of MRP and γ-glutamylcysteine synthetase overexpression with doxorubicin resistance due to increased apoptosis in SV40 large T-antigen-transformed human mesothelial cells

Ogretmen, B., Bahadori, H., McCauley, M., Boylan, A., Green, M. & Safa, A. R., Oct 21 1998, In : Cancer Chemotherapy and Pharmacology. 42, 6, p. 441-446 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Molecular mechanisms of loss of β2-microglobulin expression in drug- resistant breast cancer sublines and its involvement in drug resistance

Ogretmen, B., McCauley, M. D. & Safa, A. R., Aug 18 1998, In : Biochemistry. 37, 33, p. 11679-11691 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Photoaffinity labels for characterizing drug interaction sites of P- glycoprotein

Safa, A. R., Jan 1 1998, In : Methods in Enzymology. 292, p. 289-307 19 p.

Research output: Contribution to journalArticle

42 Scopus citations
1997

Circumvention of P-GP MDR as a function of anthracycline lipophilicity and charge

Lampidis, T. J., Kolonias, D., Podona, T., Israel, M., Safa, A. R., Lothstein, L., Savaraj, N., Tapiero, H. & Priebe, W., Mar 4 1997, In : Biochemistry. 36, 9, p. 2679-2685 7 p.

Research output: Contribution to journalArticle

68 Scopus citations
Open Access
85 Scopus citations

Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases

Olopade, O. I., Adeyanju, M. O., Safa, A. R., Hagos, F., Mick, R., Thompson, C. B. & Recant, W. M., Aug 19 1997, In : Cancer Journal from Scientific American. 3, 4, p. 230-237 8 p.

Research output: Contribution to journalArticle

187 Scopus citations
1996
58 Scopus citations

Effects of sphingosine stereoisomers on P-glycoprotein phosphorylation and vinblastine accumulation in multidrug-resistant MCF-7 cells

Sachs, C. W., Balks, L. M., Mascarella, S. W., Safa, A. R., Lewin, A. H., Loomis, C., Carroll, F. I., Bell, R. M. & Fine, R. L., Jan 1 1996, In : Biochemical Pharmacology. 52, 4, p. 603-612 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Lovastatin effects of human breast carcinoma cells. Differential toxicity of an adriamycin-resistant derivative and influence on selenocysteine tRNAs

Diamond, A. M., Jaffe, D., Murray, J. L., Safa, A. R., Samuels, B. L. & Hatfield, D. L., Aug 20 1996, In : Biochemistry and Molecular Biology International. 38, 2, p. 345-355 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Pharmacokinetic modulation of irinotecan and metabolites by cyclosporin A

Gupta, E., Safa, A. R., Wang, X. & Ratain, M. J., Mar 15 1996, In : Cancer Research. 56, 6, p. 1309-1314 6 p.

Research output: Contribution to journalArticle

81 Scopus citations