Alexander Dent

  • 5060 Citations
  • 35 h-Index
1987 …2019
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Publications 1987 2019

  • 5060 Citations
  • 35 h-Index
  • 82 Article
  • 1 Short survey
2019
1 Citation (Scopus)

BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection

Zhu, B., Zhang, R., Li, C., Jiang, L., Xiang, M., Ye, Z., Kita, H., Melnick, A. M., Dent, A. & Sun, J., Jun 11 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 24, p. 11888-11893 6 p.

Research output: Contribution to journalArticle

Tissue Survival
Virus Diseases
Orthomyxoviridae
Pneumonia
Neutrophils

CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance

Chen, Y., Yu, M., Zheng, Y., Fu, G., Xin, G., Zhu, W., Luo, L., Burns, R., Li, Q. Z., Dent, A. L., Zhu, N., Cui, W., Malherbe, L., Wen, R. & Wang, D., Dec 1 2019, In : Nature communications. 10, 1, 4415.

Research output: Contribution to journalArticle

Open Access
T-cells
Helper-Inducer T-Lymphocytes
B-Lymphocytes
Cells
Autoantibodies
1 Citation (Scopus)

Follicular regulatory T cells inhibit the development of granzyme B-expressing follicular helper T cells

Xie, M. M., Fang, S., Chen, Q., Liu, H., Wan, J. & Dent, A., Aug 22 2019, In : JCI Insight. 4, 16, e128076.

Research output: Contribution to journalArticle

Granzymes
Regulatory T-Lymphocytes
Helper-Inducer T-Lymphocytes
Germinal Center
Antibody Formation

Interleukin-13 Is Unlucky for Allergy Sufferers

Xie, M. M. & Dent, A., Jan 1 2019, (Accepted/In press) In : Trends in Pharmacological Sciences.

Research output: Contribution to journalShort survey

Allergies
Interleukin-13
Immunoglobulin E
Hypersensitivity
T-Lymphocyte Subsets
2018
11 Citations (Scopus)

Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice

Dolence, J. J., Kobayashi, T., Iijima, K., Krempski, J., Drake, L. Y., Dent, A. & Kita, H., Jan 1 2018, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Peanut Hypersensitivity
Helper-Inducer T-Lymphocytes
Interleukin-1
Immunoglobulin E
Flour
1 Citation (Scopus)

Levels of circulating follicular helper T cells, T helper 1 cells, and the prognostic significance of soluble form of CD40 ligand on survival in patients with alcoholic cirrhosis

Hollister, K., Kusumanchi, P., Ross, R. A., Chandler, K., Oshodi, A. P., Heathers, L., Teagarden, S., Wang, L., Dent, A. L. & Liangpunsakul, S., Mar 2018, In : Liver Research. 2, 1, p. 52-59 8 p.

Research output: Contribution to journalArticle

Open Access
Alcoholic Liver Cirrhosis
CD40 Ligand
Helper-Inducer T-Lymphocytes
Survival
Blood Cells
1 Citation (Scopus)

Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-b1 secretion and hematopoiesis in mice

Capitano, M., Zhao, L., Cooper, S., Thorsheim, C., Suzuki, A., Huang, X., Dent, A., Marks, M. S., Abrams, C. S. & Broxmeyer, H., Sep 6 2018, In : Blood. 132, 10, p. 1027-1038 12 p.

Research output: Contribution to journalArticle

Phospholipid Transfer Proteins
Megakaryocytes
Hematopoiesis
Transforming Growth Factors
Hematopoietic Stem Cells
2017
3 Citations (Scopus)

AMP kinase promotes Bcl6 expression in both mouse and human T cells

Xie, M. M., Amet, T., Liu, H., Yu, A. & Dent, A., Jan 1 2017, In : Molecular Immunology. 81, p. 67-75 9 p.

Research output: Contribution to journalArticle

Adenylate Kinase
T-Lymphocytes
Cell Differentiation
Interleukin-2
Glucose
8 Citations (Scopus)

Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice

Xie, M. M., Koh, B. H., Hollister, K., Wu, H., Sun, J., Kaplan, M. & Dent, A., Jul 1 2017, In : European Journal of Immunology. 47, 7, p. 1136-1141 6 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Cell Differentiation
Regulatory T-Lymphocytes
Interleukin-10
Genes
8 Citations (Scopus)

BCL6 represses antiviral resistance in follicular T helper cells

Amet, T., Son, Y. M., Jiang, L., Cheon, I. S., Huang, S., Gupta, S., Dent, A., Montaner, L. J., Yu, A. & Sun, J., Aug 1 2017, In : Journal of Leukocyte Biology. 102, 2, p. 527-536 10 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Antiviral Agents
HIV Infections
R Factors
Genes
34 Citations (Scopus)

Follicular helper T cells mediate IgE antibody response to airborne allergens

Kobayashi, T., Iijima, K., Dent, A. & Kita, H., Jan 1 2017, In : Journal of Allergy and Clinical Immunology. 139, 1, p. 300-313.e7

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Allergens
Immunoglobulin E
Antibody Formation
Cytokines
31 Citations (Scopus)

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

Jandl, C., Liu, S. M., Cañete, P. F., Warren, J., Hughes, W. E., Vogelzang, A., Webster, K., Craig, M. E., Uzel, G., Dent, A., Stepensky, P., Keller, B., Warnatz, K., Sprent, J. & King, C., Mar 17 2017, In : Nature Communications. 8, 14647.

Research output: Contribution to journalArticle

interleukins
T-cells
Cell proliferation
Regulatory T-Lymphocytes
Interleukin-2
2 Citations (Scopus)

Paracrine IL-2 is required for optimal type 2 effector cytokine production

Olson, M. R., Ulrich, B. J., Hummel, S. A., Khan, I., Meuris, B., Cherukuri, Y., Dent, A., Janga, S. C. & Kaplan, M., Jun 1 2017, In : Journal of Immunology. 198, 11, p. 4352-4359 8 p.

Research output: Contribution to journalArticle

Interleukin-2
Cytokines
Interleukin-9
Th2 Cells
Helper-Inducer T-Lymphocytes
2016
126 Citations (Scopus)

CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

Leong, Y. A., Chen, Y., Ong, H. S., Wu, D., Man, K., Deleage, C., Minnich, M., Meckiff, B. J., Wei, Y., Hou, Z., Zotos, D., Fenix, K. A., Atnerkar, A., Preston, S., Chipman, J. G., Beilman, G. J., Allison, C. C., Sun, L., Wang, P., Xu, J. & 17 others, Toe, J. G., Lu, H. K., Tao, Y., Palendira, U., Dent, A., Landay, A. L., Pellegrini, M., Comerford, I., McColl, S. R., Schacker, T. W., Long, H. M., Estes, J. D., Busslinger, M., Belz, G. T., Lewin, S. R., Kallies, A. & Yu, D., Sep 20 2016, In : Nature Immunology. 17, 10, p. 1187-1196 10 p.

Research output: Contribution to journalArticle

Virus Diseases
B-Lymphocytes
T-Lymphocytes
TCF Transcription Factors
Chemokine Receptors
41 Citations (Scopus)

Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice

Wu, H., Chen, Y., Liu, H., Xu, L. L., Teuscher, P., Wang, S., Lu, S. & Dent, A., 2016, (Accepted/In press) In : European Journal of Immunology.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Helper-Inducer T-Lymphocytes
Immunoglobulin G
Cytokines
Germinal Center
42 Citations (Scopus)

Gut microbiota regulates K/BxN autoimmune arthritis through follicular helper T but not Th17 cells

Block, K. E., Zheng, Z., Dent, A., Kee, B. L. & Huang, H., Feb 15 2016, In : Journal of Immunology. 196, 4, p. 1550-1557 8 p.

Research output: Contribution to journalArticle

Th17 Cells
Arthritis
Interleukin-17
Microbiota
Helper-Inducer T-Lymphocytes
21 Citations (Scopus)

STAT3 impairs STAT5 activation in the development of IL-9-secreting T cells

Olson, M. R., Fortino Verdan, F., Hufford, M. M., Dent, A. & Kaplan, M., Apr 15 2016, In : Journal of Immunology. 196, 8, p. 3297-3304 8 p.

Research output: Contribution to journalArticle

Interleukin-9
T-Lymphocytes
Cytokines
Interleukin-2
Interleukin-6
14 Citations (Scopus)

Stat3 Is Important for Follicular Regulatory T Cell Differentiation

Wu, H., Xie, M. M., Liu, H. & Dent, A., 2016, In : PLoS One. 11, 5, p. e0155040

Research output: Contribution to journalArticle

Germinal Center
T-cells
Regulatory T-Lymphocytes
cell differentiation
Cell Differentiation
2015
16 Citations (Scopus)

An inhibitory role for the transcription factor Stat3 in controlling IL-4 and Bcl6 expression in follicular helper T cells

Wu, H., Xu, L. L., Teuscher, P., Liu, H., Kaplan, M. & Dent, A., Sep 1 2015, In : Journal of Immunology. 195, 5, p. 2080-2089 10 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Interleukin-4
Transcription Factors
Peyer's Patches
Germinal Center
23 Citations (Scopus)

IFN-γ and IL-21 Double Producing T Cells Are Bcl6-Independent and Survive into the Memory Phase in Plasmodium chabaudi Infection

Carpio, V. H., Opata, M. M., Montañez, M. E., Banerjee, P. P., Dent, A. & Stephens, R., Dec 1 2015, In : PLoS One. 10, 12, e0144654.

Research output: Contribution to journalArticle

Plasmodium chabaudi
T-cells
Malaria
Eragrostis
T-lymphocytes
156 Citations (Scopus)

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A

Bunker, J. J., Flynn, T. M., Koval, J. C., Shaw, D. G., Meisel, M., McDonald, B. D., Ishizuka, I. E., Dent, A., Wilson, P. C., Jabri, B., Antonopoulos, D. A. & Bendelac, A., Sep 15 2015, In : Immunity. 43, 3, p. 541-553 13 p., 3150.

Research output: Contribution to journalArticle

Immunoglobulin A
Bacteria
Humoral Immunity
rRNA Genes
Small Intestine
1 Citation (Scopus)

It takes CK2 to suppress TH2

Sawant, D. V. & Dent, A., Feb 17 2015, In : Nature Immunology. 16, 3, p. 224-225 2 p.

Research output: Contribution to journalArticle

Casein Kinase II
Th2 Cells
Regulatory T-Lymphocytes
46 Citations (Scopus)

MicroRNA 21 Is a homeostatic regulator of macrophage polarization and prevents prostaglandin e2 -mediated M2 generation

Wang, Z., Brandt, S., Medeiros, A., Wang, S., Wu, H., Dent, A. & Serezani, C. H., Feb 23 2015, In : PLoS One. 10, 2, e0115855.

Research output: Contribution to journalArticle

Macrophages
MicroRNAs
microRNA
Dinoprostone
prostaglandins
11 Citations (Scopus)

PU.1 expression in T follicular helper cells limits CD40L-dependent germinal center B cell development

Awe, O., Hufford, M. M., Wu, H., Pham, D., Chang, H. C., Jabeen, R., Dent, A. & Kaplan, M., Oct 15 2015, In : Journal of Immunology. 195, 8, p. 3705-3715 11 p.

Research output: Contribution to journalArticle

CD40 Ligand
Germinal Center
Helper-Inducer T-Lymphocytes
B-Lymphocytes
T-Lymphocytes
26 Citations (Scopus)

Serum MicroRNA-21 as a Biomarker for Allergic Inflammatory Disease in Children

Sawant, D. V., Yao, W., Wright, Z., Sawyers, C., Tepper, R. S., Gupta, S. K., Kaplan, M. H. & Dent, A. L., Jan 1 2015, In : MicroRNA (Shāriqah, United Arab Emirates). 4, 1, p. 36-40 5 p.

Research output: Contribution to journalArticle

MicroRNAs
Eosinophilic Esophagitis
Biomarkers
Serum
Asthma
11 Citations (Scopus)

The transcriptional repressor Bcl6 controls the stability of regulatory T cells by intrinsic and extrinsic pathways

Sawant, D. V., Wu, H., Yao, W., Sehra, S., Kaplan, M. & Dent, A., May 1 2015, In : Immunology. 145, 1, p. 11-23 13 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Inflammation
Interleukin-17
Cytokines
T-Lymphocytes
2014
11 Citations (Scopus)

A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation

Mathew, R., Mao, A. P., Chiang, A. H., Bertozzi-Villa, C., Bunker, J. J., Scanlon, S. T., McDonald, B. D., Constantinides, M. G., Hollister, K., Singer, J. D., Dent, A., Dinner, A. R. & Bendelac, A., 2014, In : Journal of Experimental Medicine. 211, 6, p. 1137-1151 15 p.

Research output: Contribution to journalArticle

Cullin Proteins
B-Cell Lymphoma
Cell Differentiation
Ubiquitin-Protein Ligases
Thymocytes
127 Citations (Scopus)

Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice

Watchmaker, P. B., Lahl, K., Lee, M., Baumjohann, D., Morton, J., Kim, S. J., Zeng, R., Dent, A., Ansel, K. M., Diamond, B., Hadeiba, H. & Butcher, E. C., Jan 2014, In : Nature Immunology. 15, 1, p. 98-108 11 p.

Research output: Contribution to journalArticle

Dendritic Cells
Cell Differentiation
Helper-Inducer T-Lymphocytes
Mucosal Immunity
Gene Expression Profiling
9 Citations (Scopus)

Deficiency of the transcriptional repressor B cell lymphoma 6 (Bcl6) is accompanied by dysregulated lipid metabolism

LaPensee, C. R., Lin, G., Dent, A. & Schwartz, J., Jun 3 2014, In : PLoS One. 9, 6, e97090.

Research output: Contribution to journalArticle

B-Cell Lymphoma
lymphoma
Lipid Metabolism
lipid metabolism
B-lymphocytes
15 Citations (Scopus)

The role of follicular helper T cells and the germinal center in HIV-1 gp120 DNA prime and gp120 protein boost vaccination

Hollister, K., Chen, Y., Wang, S., Wu, H., Mondal, A., Clegg, N., Lu, S. & Dent, A., Jul 1 2014, In : Human vaccines & immunotherapeutics. 10, 7, p. 1985-1992 8 p.

Research output: Contribution to journalArticle

Germinal Center
Helper-Inducer T-Lymphocytes
HIV-1
Vaccination
DNA
2013
49 Citations (Scopus)

Cytokine-dependent induction of CD4++ T cells with cytotoxic potential during influenza virus infection

Hua, L., Yao, S., Pham, D., Jiang, L., Wright, J., Sawant, D., Dent, A., Braciale, T. J., Kaplan, M. & Suna, J., 2013, In : Journal of Virology. 87, 21, p. 11884-11893 10 p.

Research output: Contribution to journalArticle

Virus Diseases
Orthomyxoviridae
cytokines
T-lymphocytes
Cytokines
43 Citations (Scopus)

Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model

Hollister, K., Kusam, S., Wu, H., Clegg, N., Mondal, A., Sawant, D. V. & Dent, A., Oct 1 2013, In : Journal of Immunology. 191, 7, p. 3705-3711 7 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Interleukin-10
Cell Differentiation
Immunization
TCF Transcription Factors
52 Citations (Scopus)

The Bcl6 target gene microRNA-21 promotes Th2 differentiation by a T cell intrinsic pathway

Sawant, D. V., Wu, H., Kaplan, M. & Dent, A., Jul 2013, In : Molecular Immunology. 54, 3-4, p. 435-442 8 p.

Research output: Contribution to journalArticle

MicroRNAs
T-Lymphocytes
Genes
Regulatory T-Lymphocytes
Inflammation
17 Citations (Scopus)
Interleukin-6 Receptors
Gene encoding
T-cells
Helper-Inducer T-Lymphocytes
Transcription Factors
2012
36 Citations (Scopus)

Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing gata3 function

Sawant, D. V., Sehra, S., Nguyen, E. T., Jadhav, R., Englert, K., Shinnakasu, R., Hangoc, G., Broxmeyer, H., Nakayama, T., Perumal, N. B., Kaplan, M. & Dent, A., Nov 15 2012, In : Journal of Immunology. 189, 10, p. 4759-4769 11 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Transcriptional Activation
Transcription Factors
Bone Marrow
T-Lymphocytes
1 Citation (Scopus)

Lipids-inverted R-Us: Peroxisome generation of iNKT ligands

Brutkiewicz, R. & Dent, A., May 2012, In : Nature Immunology. 13, 5, p. 435-436 2 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
Peroxisomes
Thymocytes
Thymus Gland
Ligands
69 Citations (Scopus)

The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis

Barish, G. D., Yu, R. T., Karunasiri, M. S., Becerra, D., Kim, J., Tseng, T. W., Tai, L. J., Leblanc, M., Diehl, C., Cerchietti, L., Miller, Y. I., Witztum, J. L., Melnick, A. M., Dent, A., Tangirala, R. K. & Evans, R. M., Apr 4 2012, In : Cell Metabolism. 15, 4, p. 554-562 9 p.

Research output: Contribution to journalArticle

Atherosclerosis
Inflammation
Nuclear Receptor Co-Repressor 2
Bone Marrow
Co-Repressor Proteins
2010
165 Citations (Scopus)

Bcl-6 and NF-κB cistromes mediate opposing regulation of the innate immune response

Barish, G. D., Yu, R. T., Karunasiri, M., Ocampo, C. B., Dixon, J., Benner, C., Dent, A., Tangirala, R. K. & Evans, R. M., Dec 15 2010, In : Genes and Development. 24, 24, p. 2760-2765 6 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Innate Immunity
Chromatin Immunoprecipitation
Toll-Like Receptors
Macrophages
177 Citations (Scopus)

In vivo regulation of Bcl6 and T follicular helper cell development

Poholek, A. C., Hansen, K., Hernandez, S. G., Eto, D., Chandele, A., Weinstein, J. S., Dong, X., Odegard, J. M., Kaech, S. M., Dent, A., Crotty, S. & Craft, J., Jul 1 2010, In : Journal of Immunology. 185, 1, p. 313-326 14 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Up-Regulation
Death Domain Receptors
B-Lymphocytes
Cell Differentiation
35 Citations (Scopus)

Transcriptional repressor BCL6 controls Th17 responses by controlling gene expression in both T cells and macrophages

Mondal, A., Sawant, D. & Dent, A., Apr 15 2010, In : Journal of Immunology. 184, 8, p. 4123-4132 10 p.

Research output: Contribution to journalArticle

Macrophages
T-Lymphocytes
Gene Expression
Interleukin-17
Interleukin-4
2009
862 Citations (Scopus)

Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

Johnston, R. J., Poholek, A. C., DiToro, D., Yusuf, I., Eto, D., Barnett, B., Dent, A., Craft, J. & Crotty, S., 2009, In : Science. 325, 5943, p. 1006-1010 5 p.

Research output: Contribution to journalArticle

Cell Differentiation
B-Lymphocytes
Helper-Inducer T-Lymphocytes
T-Lymphocytes
Antibody Formation
7 Citations (Scopus)

BCL6 cooperates with CD40 stimulation and loss of p53 function to rapidly transform primary B cells

Kusam, S., Munugalavadla, V., Sawant, D. & Dent, A., Aug 15 2009, In : International Journal of Cancer. 125, 4, p. 977-981 5 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Oncogenes
Genes
Repressor Proteins
Transformed Cell Line
1 Citation (Scopus)

Going retro on lymphoma

Dent, A., Apr 9 2009, In : Blood. 113, 15, p. 3393-3394 2 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines

Ahyi, A. N. N., Chang, H. C., Dent, A., Nutt, S. L. & Kaplan, M., Aug 1 2009, In : Journal of Immunology. 183, 3, p. 1598-1606 9 p.

Research output: Contribution to journalArticle

Interleukin-10
Th2 Cells
Cytokines
Interleukin-13
Chromatin Immunoprecipitation
2008
15 Citations (Scopus)

T cell regulation of hematopoiesis

Dent, A. & Kaplan, M., May 1 2008, In : Frontiers in Bioscience. 13, 16, p. 6229-6236 8 p.

Research output: Contribution to journalArticle

T-cells
Hematopoiesis
T-Lymphocytes
Helper-Inducer T-Lymphocytes
Cytokines
2007
19 Citations (Scopus)

Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice

Broxmeyer, H., Sehra, S., Cooper, S., Toney, L. M., Kusam, S., Aloor, J. J., Marchal, C. C., Dinauer, M. C. & Dent, A., Aug 2007, In : Molecular and Cellular Biology. 27, 15, p. 5275-5285 11 p.

Research output: Contribution to journalArticle

Hematopoiesis
T-Lymphocytes
Hematopoietic Stem Cells
Stem Cell Factor
Granulocyte-Macrophage Colony-Stimulating Factor
19 Citations (Scopus)

A role for natural killer T cells and CD1d molecules in counteracting suppression of hematopoiesis in mice induced by infection with murine cytomegalovirus

Broxmeyer, H., Dent, A., Cooper, S., Hangoc, G., Wang, Z. Y., Du, W., Gervay-Haque, J., Sriram, V., Renukaradhya, G. J. & Brutkiewicz, R., Apr 2007, In : Experimental Hematology. 35, 4 SUPPL., p. 87-93 7 p.

Research output: Contribution to journalArticle

CD1d Antigen
Muromegalovirus
Natural Killer T-Cells
Hematopoiesis
Adoptive Transfer
11 Citations (Scopus)

Common mechanisms for the regulation of B cell differentiation and transformation by the transcriptional repressor protein BCL-6

Kusam, S. & Dent, A., Mar 2007, In : Immunologic Research. 37, 3, p. 177-186 10 p.

Research output: Contribution to journalArticle

Repressor Proteins
Cell Differentiation
B-Lymphocytes
Germinal Center
Plasmacytoma

Division of labor for oncogene BCL6

Dent, A., Sep 15 2007, In : Blood. 110, 6, p. 1707-1708 2 p.

Research output: Contribution to journalArticle

Oncogenes
2006
10 Citations (Scopus)

Caspase function and the immune system

Sehra, S. & Dent, A., 2006, In : Critical Reviews in Immunology. 26, 2, p. 133-148 16 p.

Research output: Contribution to journalArticle

Caspases
Immune System
Cell Death
Effector Caspases
Cell Proliferation