Andrew Saykin

  • 41079 Citations
  • 98 h-Index
1986 …2020

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2020

Association between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease

Raghavan, N. S., Raghavan, N. S., Raghavan, N. S., Raghavan, N. S., Dumitrescu, L., Dumitrescu, L., Mormino, E., Mahoney, E. R., Mahoney, E. R., Lee, A. J., Lee, A. J., Lee, A. J., Gao, Y., Gao, Y., Gao, Y., Bilgel, M., Goldstein, D., Goldstein, D., Goldstein, D., Harrison, T. & 34 others, Engelman, C. D., Saykin, A. J., Saykin, A. J., Whelan, C. D., Liu, J. Z., Jagust, W., Albert, M., Johnson, S. C., Yang, H. S., Yang, H. S., Johnson, K., Johnson, K., Aisen, P., Resnick, S. M., Sperling, R., Sperling, R., De Jager, P. L., De Jager, P. L., De Jager, P. L., De Jager, P. L., De Jager, P. L., Schneider, J., Bennett, D. A., Schrag, M., Vardarajan, B., Vardarajan, B., Vardarajan, B., Vardarajan, B., Hohman, T. J., Hohman, T. J., Mayeux, R., Mayeux, R., Mayeux, R. & Mayeux, R., 2020, (Accepted/In press) In : JAMA Neurology.

Research output: Contribution to journalArticle

Association of Blood Biomarkers With Acute Sport-Related Concussion in Collegiate Athletes: Findings From the NCAA and Department of Defense CARE Consortium

Care Consortium Investigators, Jan 3 2020, In : JAMA Network Open. 3, 1, p. e1919771

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease

The Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2020, In : Scientific reports. 10, 1, 12063.

Research output: Contribution to journalArticle

Open Access

Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs

Niculescu, A. B., Le-Niculescu, H., Roseberry, K., Wang, S., Hart, J., Kaur, A., Robertson, H., Jones, T., Strasburger, A., Williams, A., Kurian, S. M., Lamb, B., Shekhar, A., Lahiri, D. K. & Saykin, A. J., Aug 1 2020, In : Molecular Psychiatry. 25, 8, p. 1651-1672 22 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Brain-wide structural connectivity alterations under the control of Alzheimer risk genes

Yan, J., Vinesh Raja, V., Huang, Z., Amico, E., Nho, K., Fang, S., Sporns, O., Wu, Y. C., Saykin, A., Goñi, J. & Shen, L., 2020, In : International Journal of Computational Biology and Drug Design. 13, 1, p. 58-70 13 p.

Research output: Contribution to journalArticle

Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

The Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2020, In : Scientific reports. 10, 1, 2975.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau

for the Alzheimer's Disease Metabolomics Consortium (ADMC) and the Alzheimer's Disease Neuroimaging Initiative (ADNI), 2020, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Cognitive function prior to systemic therapy and subsequent well-being in older breast cancer survivors: Longitudinal findings from the Thinking and Living with Cancer Study

Kobayashi, L. C., Cohen, H. J., Zhai, W., Zhou, X., Small, B. J., Luta, G., Hurria, A., Carroll, J., Tometich, D., McDonald, B. C., Graham, D., Jim, H. S. L., Jacobsen, P., Root, J. C., Saykin, A. J., Ahles, T. A. & Mandelblatt, J., Jun 1 2020, In : Psycho-Oncology. 29, 6, p. 1051-1059 9 p.

Research output: Contribution to journalArticle

Detecting genetic associations with brain imaging phenotypes in Alzheimer's disease via a novel structured SCCA approach

Du, L., Liu, K., Yao, X., Risacher, S. L., Han, J., Saykin, A. J., Guo, L. & Shen, L., Apr 2020, In : Medical Image Analysis. 61, 101656.

Research output: Contribution to journalArticle

1 Scopus citations

Differential co-expression analysis reveals early stage transcriptomic decoupling in alzheimer's disease

Upadhyaya, Y., Xie, L., Salama, P., Cao, S., Nho, K., Saykin, A. J., Yan, J. & Alzheimer'S Disease Neuroimaging Initiative, F. T., Apr 3 2020, In : BMC Medical Genomics. 13, 53.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Dysregulated Fc gamma receptor–mediated phagocytosis pathway in Alzheimer's disease: network-based gene expression analysis

AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative, Apr 2020, In : Neurobiology of Aging. 88, p. 24-32 9 p.

Research output: Contribution to journalArticle

Open Access

Effects of chemotherapy on aging white matter microstructure: A longitudinal diffusion tensor imaging study

Chen, B. T., Ye, N., Wong, C. W., Patel, S. K., Jin, T., Sun, C. L., Rockne, R. C., Kim, H., Root, J. C., Saykin, A. J., Ahles, T. A., Holodny, A. I., Prakash, N., Mortimer, J., Sedrak, M. S., Waisman, J., Yuan, Y., Li, D., Vazquez, J., Katheria, V. & 1 others, Dale, W., Mar 2020, In : Journal of Geriatric Oncology. 11, 2, p. 290-296 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Elevated Cerebrospinal Fluid Tau Protein Concentrations on Admission Are Associated with Long-term Neurologic and Cognitive Impairment in Ugandan Children with Cerebral Malaria

Datta, D., Conroy, A. L., Castelluccio, P. F., Ssenkusu, J. M., Park, G. S., Opoka, R. O., Bangirana, P., Idro, R., Saykin, A. J. & John, C. C., Mar 3 2020, In : Clinical Infectious Diseases. 70, 6, p. 1161-1168 8 p.

Research output: Contribution to journalArticle

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

The Alzheimer’s Disease Genetics Consortium, Dec 1 2020, In : Nature communications. 11, 1, 667.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

The Alzheimer Disease Neuroimaging Initiative, Dec 1 2020, In : Nature communications. 11, 1, 411.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2020, In : Nature communications. 11, 1, 347.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways

the Alzheimer's Disease Genetics Consortium, Aug 1 2020, In : Alzheimer's and Dementia. 16, 8, p. 1134-1145 12 p.

Research output: Contribution to journalArticle

Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology

Nho, K., Nudelman, K., Allen, M., Hodges, A., Kim, S., Risacher, S. L., Apostolova, L. G., Lin, K., Lunnon, K., Wang, X., Burgess, J. D., Ertekin-Taner, N., Petersen, R. C., Wang, L., Qi, Z., He, A., Neuhaus, I., Patel, V., Foroud, T., Faber, K. M. & 4 others, Lovestone, S., Simmons, A., Weiner, M. W. & Saykin, A. J., 2020, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease

Vasanthakumar, A., Davis, J. W., Idler, K., Waring, J. F., Asque, E., Riley-Gillis, B., Grosskurth, S., Srivastava, G., Kim, S., Kim, S., Nho, K., Nudelman, K. N. H., Nudelman, K. N. H., Faber, K., Sun, Y., Sun, Y., Foroud, T. M., Estrada, K., Estrada, K., Apostolova, L. G. & 3 others, Li, Q. S., Li, Q. S. & Saykin, A. J., Jun 15 2020, In : Clinical Epigenetics. 12, 1, 84.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Identification of functionally connected multi-omic biomarkers for Alzheimer’s disease using modularity-constrained Lasso

Xie, L., Varathan, P., Nho, K., Saykin, A. J., Salama, P. & Yan, J., Jun 2020, In : PloS one. 15, 6, e0234748.

Research output: Contribution to journalArticle

Open Access

Identifying diagnosis-specific genotype-phenotype associations via joint multitask sparse canonical correlation analysis and classification

Alzheimer’s Disease Neuroimaging Initiative, Jul 1 2020, In : Bioinformatics (Oxford, England). 36, 1, p. i371-i379

Research output: Contribution to journalArticle

Open Access

Imaging genomics discovery of a new risk variant for Alzheimer's disease in the postsynaptic SHARPIN gene

Soheili-Nezhad, S., Jahanshad, N., Guelfi, S., Khosrowabadi, R., Saykin, A. J., Thompson, P. M., Beckmann, C. F., Sprooten, E. & Zarei, M., Sep 1 2020, In : Human Brain Mapping. 41, 13, p. 3737-3748 12 p.

Research output: Contribution to journalArticle

Open Access

Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study

Wu, Y. C., Harezlak, J., Elsaid, N. M. H., Lin, Z., Wen, Q., Mustafi, S. M., Riggen, L. D., Koch, K. M., Nencka, A. S., Meier, T. B., Mayer, A. R., Wang, Y., Giza, C. C., DiFiori, J. P., Guskiewicz, K. M., Mihalik, J. P., LaConte, S. M., Duma, S. M., Broglio, S. P., Saykin, A. J. & 2 others, McCrea, M. A. & McAllister, T. W., Aug 18 2020, In : Neurology. 95, 7, p. e781-e792

Research output: Contribution to journalArticle

Open Access

MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties

Chopra, N., Wang, R., Maloney, B., Nho, K., Beck, J. S., Pourshafie, N., Niculescu, A., Saykin, A. J., Rinaldi, C., Counts, S. E. & Lahiri, D. K., 2020, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Multi-modal neuroimaging feature selection with consistent metric constraint for diagnosis of Alzheimer's disease

for the Alzheimer's Disease Neuroimaging Initiative, Feb 2020, In : Medical Image Analysis. 60, 101625.

Research output: Contribution to journalArticle

4 Scopus citations

Neurodegenerative changes in early-and late-onset cognitive impairment with and without brain amyloidosis

Stage, E. C., Svaldi, D., Phillips, M., Canela, V. H., Duran, T., Goukasian, N., Risacher, S. L., Saykin, A. J. & Apostolova, L. G., Aug 5 2020, In : Alzheimer's Research and Therapy. 12, 1, 93.

Research output: Contribution to journalArticle

Open Access

Neurodegenerative Patterns of Cognitive Clusters of Early-Onset Alzheimer's Disease Subjects: Evidence for Disease Heterogeneity

Phillips, M. L., Stage, E. C., Lane, K. A., Gao, S., Risacher, S. L., Goukasian, N., Saykin, A. J., Carrillo, M. C., DIckerson, B. C., Rabinovici, G. D. & Apostolova, L. G., Feb 1 2020, In : Dementia and Geriatric Cognitive Disorders. 48, 3-4, p. 131-142 12 p.

Research output: Contribution to journalArticle

Novel Markers of Angiogenesis in the Setting of Cognitive Impairment and Dementia

Callahan, C. M., Apostolova, L. G., Gao, S., Risacher, S. L., Case, J., Saykin, A. J., Lane, K. A., Swinford, C. G. & Yoder, M. C., Jan 1 2020, In : Journal of Alzheimer's Disease. 75, 3, p. 959-969 11 p.

Research output: Contribution to journalArticle

Regional imaging genetic enrichment analysis

Yao, X., Cong, S., Yan, J., Risacher, S. L., Saykin, A. J., Moore, J. H. & Shen, L., Apr 15 2020, In : Bioinformatics. 36, 8, p. 2554-2560 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Resting-state fMRI metrics in acute sport-related concussion and their association with clinical recovery: A study from the NCAA-DOD CARE consortium

Meier, T. B., Giraldo-Chica, M., España, L. Y., Mayer, A. R., Harezlak, J., Nencka, A. S., Wang, Y., Koch, K. M., Wu, Y. C., Saykin, A. J., Giza, C. C., Goldman, J., Difiori, J. P., Guskiewicz, K. M., Mihalik, J. P., Brooks, A., Broglio, S. P., McAllister, T. & McCrea, M. A., Jan 1 2020, In : Journal of neurotrauma. 37, 1, p. 152-162 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease

for the Dominantly Inherited Alzheimer Network, Aug 2020, In : Neurobiology of Disease. 142, 104960.

Research output: Contribution to journalArticle

Open Access

Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers

Alzheimer's Disease Neuroimaging Initiative and Alzheimer's Disease Metabolomics Consortium, May 19 2020, In : Neurology. 94, 20, p. e2088-e2098

Research output: Contribution to journalArticle

2 Scopus citations

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

Arnold, M., Nho, K., Kueider-Paisley, A., Massaro, T., Huynh, K., Brauner, B., MahmoudianDehkordi, S., Louie, G., Moseley, M. A., Thompson, J. W., John-Williams, L. S., Tenenbaum, J. D., Blach, C., Chang, R., Brinton, R. D., Baillie, R., Han, X., Trojanowski, J. Q., Shaw, L. M., Martins, R. & 10 others, Weiner, M. W., Trushina, E., Toledo, J. B., Meikle, P. J., Bennett, D. A., Krumsiek, J., Doraiswamy, P. M., Saykin, A. J., Kaddurah-Daouk, R. & Kastenmüller, G., Dec 1 2020, In : Nature communications. 11, 1, 1148.

Research output: Contribution to journalArticle

Open Access

Symptom burden among older breast cancer survivors: The Thinking and Living With Cancer (TLC) study

Mandelblatt, J. S., Zhai, W., Ahn, J., Small, B. J., Ahles, T. A., Carroll, J. E., Denduluri, N., Dilawari, A., Extermann, M., Graham, D., Hurria, A., Isaacs, C., Jacobsen, P. B., Jim, H. S. L., Luta, G., McDonald, B. C., Patel, S. K., Root, J. C., Saykin, A. J., Tometich, D. B. & 2 others, Zhou, X. & Cohen, H. J., Mar 15 2020, In : Cancer. 126, 6, p. 1183-1192 10 p.

Research output: Contribution to journalArticle

Systems modeling of white matter microstructural abnormalities in Alzheimer's disease

the Alzheimer's Disease Neuroimaging Initiative (ADNI), 2020, In : NeuroImage: Clinical. 26, 102203.

Research output: Contribution to journalArticle

Open Access

Testing influences of APOE and BDNF genes and heart failure on cognitive function

Jung, M., Apostolova, L. G., Gao, S., Burney, H. N., Lai, D., Foroud, T., Saykin, A. J. & Pressler, S. J., 2020, (Accepted/In press) In : Heart and Lung.

Research output: Contribution to journalArticle

The Association Between Persistent White-Matter Abnormalities and Repeat Injury After Sport-Related Concussion

Brett, B. L., Wu, Y. C., Mustafi, S. M., Saykin, A. J., Koch, K. M., Nencka, A. S., Giza, C. C., Goldman, J., Guskiewicz, K. M., Mihalik, J. P., Duma, S. M., Broglio, S. P., McAllister, T. W., McCrea, M. A. & Meier, T. B., Jan 21 2020, In : Frontiers in Neurology. 10, 1345.

Research output: Contribution to journalArticle

Open Access

The genetic architecture of the human cerebral cortex

Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group, Mar 20 2020, In : Science. 367, 6484, aay6690.

Research output: Contribution to journalArticle

29 Scopus citations

Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data

UK Brain Expression Consortium & Alzheimer's Disease Neuroimaging Initiative, Nov 2020, In : Neurobiology of Aging. 95, p. 81-93 13 p.

Research output: Contribution to journalArticle

Open Access
2019

A blood-based signature of cerebrospinal fluid Aβ 1–42 status

Alzheimer’s Disease Metabolomics Consortium & Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 4163.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium, Jan 2019, In : Alzheimer's and Dementia. 15, 1, p. 76-92 17 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers

Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium, Feb 2019, In : Alzheimer's and Dementia. 15, 2, p. 232-244 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data

The Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 19589.

Research output: Contribution to journalArticle

Open Access

Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers

Alzheimer’s Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium, Jul 3 2019, In : JAMA Network Open. 2, 7, p. e197978

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Associations between Depression, Traumatic Brain Injury, and Cognitively-Defined Late-Onset Alzheimer's Disease Subgroups

the Executive Prominent AD (EPAD) investigators, Jan 1 2019, In : Journal of Alzheimer's Disease. 70, 2, p. 609-617 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Bile acids targeted metabolomics and medication classification data in the ADNI1 and ADNIGO/2 cohorts

Alzheimer’s Disease Neuroimaging Initiative & Alzheimer’s Disease Metabolomics Consortium, Oct 17 2019, In : Scientific Data. 6, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Cerebral blood flow in acute concussion: preliminary ASL findings from the NCAA-DoD CARE consortium

Wang, Y., Nencka, A. S., Meier, T. B., Guskiewicz, K., Mihalik, J. P., Alison Brooks, M., Saykin, A. J., Koch, K. M., Wu, Y. C., Nelson, L. D., McAllister, T. W., Broglio, S. P. & McCrea, M. A., Oct 1 2019, In : Brain Imaging and Behavior. 13, 5, p. 1375-1385 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Correction to: Genetic data and cognitively defined late-onset Alzheimer’s disease subgroups (Molecular Psychiatry, (2018), 10.1038/s41380-018-0298-8)

EPAD Study Group, Investigators from ACT, Investigators from ROS, Investigators from MAP, Investigators from ADNI & Investigators from the University of Pittsburgh ADRC, Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
18 Scopus citations

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Jia, T., Chu, C., Liu, Y., van Dongen, J., Papastergios, E., Armstrong, N. J., Bastin, M. E., Carrillo-Roa, T., den Braber, A., Harris, M., Jansen, R., Liu, J., Luciano, M., Ori, A. P. S., Roiz Santiañez, R., Ruggeri, B., Sarkisyan, D., Shin, J., Sungeun, K., Tordesillas Gutiérrez, D. & 62 others, van’t Ent, D., Ames, D., Artiges, E., Bakalkin, G., Banaschewski, T., Bokde, A. L. W., Brodaty, H., Bromberg, U., Brouwer, R., Büchel, C., Burke Quinlan, E., Cahn, W., de Zubicaray, G. I., Ehrlich, S., Ekström, T. J., Flor, H., Fröhner, J. H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Hoare, J., Ittermann, B., Jahanshad, N., Jiang, J., Kwok, J. B., Martin, N. G., Martinot, J. L., Mather, K. A., McMahon, K. L., McRae, A. F., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Sämann, P. G., Schofield, P. R., Smolka, M. N., Stein, D. J., Strike, L. T., Teeuw, J., Thalamuthu, A., Trollor, J., Walter, H., Wardlaw, J. M., Wen, W., Whelan, R., Apostolova, L. G., Binder, E. B., Boomsma, D. I., Calhoun, V., Crespo-Facorro, B., Deary, I. J., Hulshoff Pol, H., Ophoff, R. A., Pausova, Z., Sachdev, P. S., Saykin, A., Wright, M. J., Thompson, P. M., Schumann, G. & Desrivières, S., 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations