Andy Hudmon

  • 3344 Citations
  • 28 h-Index
19952019

Research output per year

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Publications

  • 3344 Citations
  • 28 h-Index
  • 51 Article
  • 3 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2019

Assemblies of calcium/calmodulin-dependent kinase II with actin and their dynamic regulation by calmodulin in dendritic spines

Wang, Q., Chen, M., Schafer, N. P., Bueno, C., Song, S. S., Hudmon, A., Wolynes, P. G., Neal Waxham, M. & Cheung, M. S., Sep 17 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 38, p. 18937-18942 6 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Calcium/calmodulin-dependent protein kinase II regulation of IKs during sustained β-adrenergic receptor stimulation

Shugg, T., Johnson, D. E., Shao, M., Lai, X., Witzmann, F., Cummins, T. R., Rubart-Von-der Lohe, M., Hudmon, A. & Overholser, B. R., Jun 2018, In : Heart Rhythm. 15, 6, p. 895-904 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice

Lee, W. H., Li, L. L., Chawla, A., Hudmon, A., Lai, Y. Y., Courtney, M. J. & Hohmann, A. G., May 1 2018, In : Pain. 159, 5, p. 849-863 15 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Activation State-Dependent Substrate Gating in Ca2+/Calmodulin-Dependent Protein Kinase II

Johnson, D. E. & Hudmon, A., Jan 1 2017, In : Neural Plasticity. 2017, 9601046.

Research output: Contribution to journalArticle

1 Scopus citations

Constitutive regulation of the glutamate/aspartate transporter EAAT1 by Calcium-Calmodulin-Dependent Protein Kinase II

Chawla, A. R., Johnson, D. E., Zybura, A. S., Leeds, B. P., Nelson, R. M. & Hudmon, A., Feb 1 2017, In : Journal of Neurochemistry. 140, 3, p. 421-434 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth

Zhou, D., Springer, M. Z., Xu, D., Liu, D., Hudmon, A., Macleod, K. F. & Meroueh, S. O., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 12, p. 2995-3005 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structure-Based Target-Specific Screening Leads to Small-Molecule CaMKII Inhibitors

Xu, D., Li, L., Zhou, D., Liu, D., Hudmon, A. & Meroueh, S. O., Jan 1 2017, In : ChemMedChem. 12, 9, p. 660-677 18 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016
18 Scopus citations
3 Scopus citations

Novel Roles for Peroxynitrite in Angiotensin II and CaMKII Signaling

Zhou, C., Ramaswamy, S. S., Johnson, D. E., Vitturi, D. A., Schopfer, F. J., Freeman, B. A., Hudmon, A. & Levitan, E. S., Apr 15 2016, In : Scientific reports. 6, 23416.

Research output: Contribution to journalArticle

2 Scopus citations
2015

CaMKII controls whether touch is painful

Yu, H., Pan, B., Weyer, A., Wu, H. E., Meng, J., Fischer, G., Vilceanu, D., Light, A. R., Stucky, C., Rice, F. L., Hudmon, A. & Hogan, Q., Oct 21 2015, In : Journal of Neuroscience. 35, 42, p. 14086-14102 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Differential expression of CaMKII isoforms and overall kinase activity in rat dorsal root ganglia after injury

Bangaru, M. L. Y., Meng, J., Kaiser, D. J., Yu, H., Fischer, G., Hogan, Q. H. & Hudmon, A., Aug 6 2015, In : Neuroscience. 300, p. 116-127 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Excitotoxic insult results in a long-lasting activation of CaMKIIα and mitochondrial damage in living hippocampal neurons

Otmakhov, N., Gorbacheva, E. V., Regmi, S., Yasuda, R., Hudmon, A. & Lisman, J., Mar 20 2015, In : PloS one. 10, 3, e0120881.

Research output: Contribution to journalArticle

6 Scopus citations

Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C during Increased Pacing Frequency or β1-Adrenergic Stimulation

Tong, C. W., Wu, X., Liu, Y., Rosas, P. C., Sadayappan, S., Hudmon, A., Muthuchamy, M., Powers, P. A., Valdivia, H. H. & Moss, R. L., May 4 2015, In : Circulation: Heart Failure. 8, 3, p. 595-604 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egress

Gaji, R. Y., Johnson, D. E., Treeck, M., Wang, M., Hudmon, A. & Arrizabalaga, G., Nov 1 2015, In : PLoS Pathogens. 11, 11, e1005268.

Research output: Contribution to journalArticle

30 Scopus citations

Proteome-wide lysine acetylation in cortical astrocytes and alterations that occur during infection with brain parasite Toxoplasma gondii

Bouchut, A., Chawla, A. R., Jeffers, V., Hudmon, A. & Sullivan, W. J., Mar 18 2015, In : PloS one. 10, 3, e0117966.

Research output: Contribution to journalArticle

12 Scopus citations

Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics

Lee, W. H., Xu, Z., Ashpole, N. M., Hudmon, A., Kulkarni, P. M., Thakur, G. A., Lai, Y. Y. & Hohmann, A. G., Aug 13 2015, In : Neuropharmacology. 97, p. 464-475 12 p., 5884.

Research output: Contribution to journalArticle

28 Scopus citations
2014

Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet β-cells

Ramalingam, L., Lu, J., Hudmon, A. & Thurmond, D. C., Dec 1 2014, In : Biochemical Journal. 464, 2, p. 251-258 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Mitochondrial Ca2+ uniporter and CaMKII in heart

Fieni, F., Johnson, D. E., Hudmon, A. & Kirichok, Y., Sep 25 2014, In : Nature. 513, 7519, p. E1-E2

Research output: Contribution to journalArticle

26 Scopus citations

Regulation of voltage-gated Ca2+ currents by Ca2+/calmodulin-dependent protein kinase II in resting sensory neurons

Kostic, S., Pan, B., Guo, Y., Yu, H., Sapunar, D., Kwok, W. M., Hudmon, A., Wu, H. E. & Hogan, Q. H., Sep 2014, In : Molecular and Cellular Neuroscience. 62, p. 10-18 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP

Ashpole, N. M., Chawla, A. R., Martin, M. P., Brustovetskys, T., Brustovetskys, N. & Hudmon, A., May 17 2013, In : Journal of Biological Chemistry. 288, 20, p. 14599-14611 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases

Adler, J. J., Johnson, D. E., Heller, B. L., Bringman, L. R., Ranahan, W. P., Conwell, M. D., Sun, Y., Hudmon, A. & Wells, C. D., Oct 22 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 43, p. 17368-17373 6 p.

Research output: Contribution to journalArticle

84 Scopus citations
2012

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

Ashpole, N. M., Herren, A. W., Ginsburg, K. S., Brogan, J. D., Johnson, D. E., Cummins, T. R., Bers, D. M. & Hudmon, A., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 19856-19869 14 p.

Research output: Contribution to journalArticle

108 Scopus citations

Ca2+-dependent regulation of Ca2+ currents in rat primary afferent neurons: Role of caMKII and the effect of injury

Tang, Q., Bangaru, M. L. Y., Kostic, S., Pan, B., Wu, H. E., Koopmeiners, A. S., Yu, H., Fischer, G. J., Bruce Mccallum, J., Kwok, W. M., Hudmon, A. & Hogan Dr., Q. H., Aug 22 2012, In : Journal of Neuroscience. 32, 34, p. 11737-11749 13 p.

Research output: Contribution to journalArticle

23 Scopus citations
61 Scopus citations

Quantification of gene expression after painful nerve injury: Validation of optimal reference genes

Bangaru, M. L. Y., Park, F., Hudmon, A., McCallum, J. B. & Hogan, Q. H., Mar 1 2012, In : Journal of Molecular Neuroscience. 46, 3, p. 497-504 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity

Song, W., Xiao, Y., Chen, H., Ashpole, N. M., Piekarz, A. D., Ma, P., Hudmon, A., Cummins, T. R. & Shou, W., Oct 1 2012, In : Journal of Physiology. 590, 20, p. 5123-5139 17 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011

Excitotoxic neuroprotection and vulnerability with CaMKII inhibition

Ashpole, N. M. & Hudmon, A., Apr 1 2011, In : Molecular and Cellular Neuroscience. 46, 4, p. 720-730 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

Neuroprotection against traumatic brain Injury by a peptide derived from the Collapsin Response Mediator Protein 2 (CRMP2)

Brittain, J. M., Chen, L., Wilson, S. M., Brustovetsky, T., Gao, X., Ashpole, N. M., Molosh, A. I., You, H., Hudmon, A., Shekhar, A., White, F. A., Zamponi, G. W., Brustovetsky, N., Chen, J. & Khanna, R., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37778-37792 15 p.

Research output: Contribution to journalArticle

62 Scopus citations

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

Brittain, J. M., Duarte, D. B., Wilson, S. M., Zhu, W., Ballard, C., Johnson, P. L., Liu, N., Xiong, W., Ripsch, M. S., Wang, Y., Fehrenbacher, J. C., Fitz, S. D., Khanna, M., Park, C. K., Schmutzler, B. S., Cheon, B. M., Due, M. R., Brustovetsky, T., Ashpole, N. M., Hudmon, A. & 12 others, Meroueh, S. O., Hingtgen, C. M., Brustovetsky, N., Ji, R. R., Hurley, J. H., Jin, X., Shekhar, A., Xu, X. M., Oxford, G. S., Vasko, M. R., White, F. A. & Khanna, R., Jul 1 2011, In : Nature Medicine. 17, 7, p. 822-829 8 p.

Research output: Contribution to journalArticle

140 Scopus citations
29 Scopus citations
2009

Low doses of estradiol partly inhibit release of GH in sheep without affecting basal levels

Hudmon, A., Davenport, G., Coleman, E. S. & Sartin, J. L., Oct 1 2009, In : Domestic Animal Endocrinology. 37, 3, p. 181-187 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2008

Phosphorylation of sodium channel Nav1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons

Hudmon, A., Choi, J. S., Tyrrell, L., Black, J. A., Rush, A. M., Waxman, S. G. & Dib-Hajj, S. D., Mar 19 2008, In : Journal of Neuroscience. 28, 12, p. 3190-3201 12 p.

Research output: Contribution to journalArticle

122 Scopus citations
2007

Displacement of α-actinin from the NMDA receptor NR1 C0 domain by Ca2+/calmodulin promotes CaMKII binding

Merrill, M. A., Malik, Z., Akyol, Z., Bartos, J. A., Leonard, A. S., Hudmon, A., Shea, M. A. & Hell, J. W., Jul 24 2007, In : Biochemistry. 46, 29, p. 8485-8497 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

Yu, X., Sun, J. P., He, Y., Guo, X., Liu, S., Zhou, B., Hudmon, A. & Zhang, Z. Y., Dec 11 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 50, p. 19767-19772 6 p.

Research output: Contribution to journalArticle

108 Scopus citations
2006

Calmodulin regulates current density and frequency-dependent inhibition of sodium channel Nav1.8 in DRG neurons

Choi, J. S., Hudmon, A., Waxman, S. G. & Dib-Hajj, S. D., Jul 13 2006, In : Journal of Neurophysiology. 96, 1, p. 97-108 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Head Module Control of Mediator Interactions

Takagi, Y., Calero, G., Komori, H., Brown, J. A., Ehrensberger, A. H., Hudmon, A., Asturias, F. & Kornberg, R. D., Aug 4 2006, In : Molecular Cell. 23, 3, p. 355-364 10 p.

Research output: Contribution to journalArticle

94 Scopus citations
2005

A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association

Hudmon, A., LeBel, E., Roy, H., Sik, A., Schulman, H., Waxham, M. N. & De Koninck, P., Jul 27 2005, In : Journal of Neuroscience. 25, 30, p. 6971-6983 13 p.

Research output: Contribution to journalArticle

119 Scopus citations

CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation

Hudmon, A., Schulman, H., Kim, J., Maltez, J. M., Tsien, R. W. & Pitt, G. S., Nov 7 2005, In : Journal of Cell Biology. 171, 3, p. 537-547 11 p.

Research output: Contribution to journalArticle

232 Scopus citations

Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase

Wittmack, E. K., Rush, A. M., Hudmon, A., Waxman, S. G. & Dib-Hajj, S. D., Jul 13 2005, In : Journal of Neuroscience. 25, 28, p. 6621-6630 10 p.

Research output: Contribution to journalArticle

82 Scopus citations
2003

Revised Subunit Structure of Yeast Transcription Factor IIH (TFIIH) and Reconciliation with Human TFIIH

Takagi, Y., Komori, H., Chang, W. H., Hudmon, A., Erdjument-Bromage, H., Tempst, P. & Kornberg, R. D., Nov 7 2003, In : Journal of Biological Chemistry. 278, 45, p. 43897-43900 4 p.

Research output: Contribution to journalArticle

32 Scopus citations
2002

Chemical quenched flow kinetic studies indicate an intraholoenzyme autophosphorylation mechanism for Ca2+/calmodulin-dependent protein kinase II

Michael Bradshaw, J., Hudmon, A. & Schulman, H., Jun 7 2002, In : Journal of Biological Chemistry. 277, 23, p. 20991-20998 8 p.

Research output: Contribution to journalArticle

56 Scopus citations
2001

CaM-kinase II dephosphorylates Thr286 by a reversal of the autophosphorylation reaction

Kim, S. A., Hudmon, A., Volmer, A. & Waxham, M. N., Jan 1 2001, In : Biochemical and Biophysical Research Communications. 282, 3, p. 773-780 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Light scattering and transmission electron microscopy studies reveal a mechanism for calcium/calmodulin-dependent protein kinase II self-association

Hudmon, A., Kim, S. A., Kolb, S. J., Stoops, J. K. & Neal Waxham, M., Mar 19 2001, In : Journal of Neurochemistry. 76, 5, p. 1364-1375 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Molecular Basis of Calmodulin Tethering and Ca2+-dependent Inactivation of L-type Ca2+ Channels

Pitt, G. S., Zühlke, R. D., Hudmon, A., Schulman, H., Reuter, H. & Tsien, R. W., Aug 17 2001, In : Journal of Biological Chemistry. 276, 33, p. 30794-30802 9 p.

Research output: Contribution to journalArticle

233 Scopus citations

Molecular Characterization of Calmodulin Trapping by Calcium/Calmodulin-dependent Protein Kinase II

Singla, S. I., Hudmon, A., Goldberg, J. M., Smith, J. L. & Schulman, H., Aug 3 2001, In : Journal of Biological Chemistry. 276, 31, p. 29353-29360 8 p.

Research output: Contribution to journalArticle

57 Scopus citations
2000
134 Scopus citations
1998

Identification of domains essential for the assembly of calcium/calmodulin-dependent protein kinase II holoenzymes

Kolb, S. J., Hudmon, A., Ginsberg, T. R. & Waxham, M. N., Nov 20 1998, In : Journal of Biological Chemistry. 273, 47, p. 31555-31564 10 p.

Research output: Contribution to journalArticle

57 Scopus citations
1996

Inactivation and self-association of Ca2+/calmodulin-dependent protein kinase II during autophosphorylation

Hudmon, A., Aronowski, J., Kolb, S. J. & Waxham, M. N., Apr 12 1996, In : Journal of Biological Chemistry. 271, 15, p. 8800-8808 9 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations
1995

Ca2+/Calmodulin Kinase II Translocates in a Hippocampal Slice Model of Ischemia

Kolb, S. J., Hudmon, A. & Waxham, M. N., May 1995, In : Journal of Neurochemistry. 64, 5, p. 2147-2152 6 p.

Research output: Contribution to journalArticle

44 Scopus citations