Ann Hake

  • Associate Professor of Clinical Neurology, Neurology
  • 5441 Citations
  • 26 h-Index
19982020

Research output per year

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Publications

1998
8 Scopus citations
2000

Association of an interleukin 1α polymorphism with Alzheimer's disease

Du, Y., Dodel, R. C., Eastwood, B. J., Bales, K. R., Gao, F., Lohmüller, F., Müller, U., Kurz, A., Zimmer, R., Evans, R. M., Hake, A., Gasser, T., Oertel, W. H., Griffin, W. S. T., Paul, S. M. & Farlow, M. R., Sep 5 2000, In : Neurology. 55, 4, p. 480-483 4 p.

Research output: Contribution to journalArticle

181 Scopus citations

Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene

Murrell, J. R., Hake, A. M., Quaid, K. A., Farlow, M. R. & Ghetti, B., Jun 2000, In : Archives of Neurology. 57, 6, p. 885-887 3 p.

Research output: Contribution to journalArticle

Open Access
70 Scopus citations

Estrogen for Alzheimer's disease in women: Randomized, double-blind, placebo-controlled trial

Henderson, V. W., Paganini-Hill, A., Miller, B. L., Elble, R. J., Reyes, P. F., Shoupe, D., McCleary, C. A., Klein, R. A., Hake, A. M. & Farlow, M. R., Jan 25 2000, In : Neurology. 54, 2, p. 295-301 7 p.

Research output: Contribution to journalArticle

494 Scopus citations

Presymptomatic genetic testing with an APP mutation in Early-onset Alzheimer disease: A descriptive study of sibship dynamics

Quaid, K. A., Murrell, J. R., Hake, A. M., Farlow, M. R. & Ghetti, B., 2000, In : Journal of Genetic Counseling. 9, 4, p. 327-341 15 p.

Research output: Contribution to journalReview article

7 Scopus citations

α2 Macroglobulin and the risk of Alzheimer's disease

Dodel, R. C., Du, Y., Bales, K. R., Gao, F., Eastwood, B., Glazier, B., Zimmer, R., Cordell, B., Hake, A., Evans, R., Gallagher-Thompson, D., Thompson, L. W., Tinklenberg, J. R., Pfefferbaum, A., Sullivan, E. V., Yesavage, J., Altstiel, L., Gasser, T., Farlow, M. R., Murphy, G. M. & 1 others, Paul, S. M., Jan 25 2000, In : Neurology. 54, 2, p. 438-442 5 p.

Research output: Contribution to journalArticle

65 Scopus citations
2001

New concepts in the drug therapy of Alzheimer's disease

Hake, A. M. & Farlow, M. R., Dec 17 2001, In : Expert opinion on pharmacotherapy. 2, 12, p. 1975-1983 9 p.

Research output: Contribution to journalReview article

5 Scopus citations

Response of patients with Alzheimer disease to rivastigmine treatment is predicted by the rate of disease progression

Farlow, M. R., Hake, A., Messina, J., Hartman, R., Veach, J. & Anand, R., Jan 1 2001, In : Archives of Neurology. 58, 3, p. 417-422 6 p.

Research output: Contribution to journalArticle

Open Access
84 Scopus citations

Use of cholinesterase inhibitors for treatment of Alzheimer disease

Hake, A. M., Jul 1 2001, In : Cleveland Clinic Journal of Medicine. 68, 7, p. 608-616 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
2002

A phase I study of AIT-082 in healthy elderly volunteers

Grundman, M., Farlow, M., Peavy, G., Kim, H. T., Capparelli, E., Schultz, A. N., Salmon, D. P., Ferris, S. H., Mohs, R., Thomas, R. G., Schafer, K., Campbell, K., Hake, A. M., Schoos, B. & Thal, L. J., Jan 1 2002, In : Journal of Molecular Neuroscience. 18, 3, p. 283-293 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

The treatment of Alzheimer's disease: The approach from a clinical specialist in the Trenches

Hake, A. M., Aug 1 2002, In : Seminars in Neurology. 22, 1, p. 71-74 4 p.

Research output: Contribution to journalReview article

7 Scopus citations
2003

A multicenter, randomized, placebo controlled, multiple-dose, safety and pharmacokinetic study of AIT-082 (Neotrofin™) in mild Alzheimer's disease patients

Grundman, M., Capparelli, E., Kim, H. T., Morris, J. C., Farlow, M., Rubin, E. H., Heidebrink, J., Hake, A., Ho, G., Schultz, A. N., Schafer, K., Houston, W., Thomas, R. & Thal, L. J., Jun 20 2003, In : Life Sciences. 73, 5, p. 539-553 15 p.

Research output: Contribution to journalArticle

33 Scopus citations

Visual function in Hungtington's disease patients and presymptomatic gene carriers

O'Donnell, B. F., Wilt, M. A., Hake, A. M., Stout, J. C., Kirkwood, S. C. & Foroud, T., Sep 1 2003, In : Movement Disorders. 18, 9, p. 1027-1034 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2004

Oculomotor control in asymptomatic and recently diagnosed individuals with the genetic marker for Huntington's disease

Blekher, T. M., Yee, R. D., Kirkwood, S. C., Hake, A. M., Stout, J. C., Weaver, M. R. & Foroud, T. M., Oct 1 2004, In : Vision Research. 44, 23, p. 2729-2736 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

On the horizon: Pathways for drug development in Alzheimer's disease

Hake, A. M. & Farlow, M. R., Feb 2004, In : Clinics in Geriatric Medicine. 20, 1, p. 141-152 12 p.

Research output: Contribution to journalReview article

1 Scopus citations
2005

The use of memantine in dementia with Lewy bodies

Sabbagh, M. N., Hake, A. M., Ahmed, S. & Farlow, M. R., Jan 1 2005, In : Journal of Alzheimer's Disease. 7, 4, p. 285-289 5 p.

Research output: Contribution to journalReview article

50 Scopus citations
2007

Efficacy and safety of galantamine in patients with dementia with Lewy bodies: A 24-week open-label study

Edwards, K., Royall, D., Hershey, L., Lichter, D., Hake, A., Farlow, M., Pasquier, F. & Johnson, S., May 1 2007, In : Dementia and Geriatric Cognitive Disorders. 23, 6, p. 401-405 5 p.

Research output: Contribution to journalArticle

61 Scopus citations
2010

Use of anticholinergics and the risk of cognitive impairment in an African American population

Campbell, N. L., Boustani, M. A., Lane, K. A., Gao, S., Hendrie, H., Khan, B. A., Murrell, J. R., Unverzagt, F. W., Hake, A., Smith-Gamble, V. & Hall, K., Jul 13 2010, In : Neurology. 75, 2, p. 152-159 8 p.

Research output: Contribution to journalArticle

95 Scopus citations
2011

Accelerated weight loss and incident dementia in an elderly african-american cohort

Gao, S., Nguyen, J. T., Hendrie, H. C., Unverzagt, F. W., Hake, A., Smith-Gamble, V. & Hall, K., Jan 2011, In : Journal of the American Geriatrics Society. 59, 1, p. 18-25 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Implementing innovative models of dementia care: The Healthy Aging Brain Center

Boustani, M. A., Sachs, G. A., Alder, C. A., Munger, S., Schubert, C. C., Guerriero Austrom, M., Hake, A. M., Unverzagt, F. W., Farlow, M., Matthews, B. R., Perkins, A. J., Beck, R. A. & Callahan, C. M., Jan 1 2011, In : Aging and Mental Health. 15, 1, p. 13-22 10 p.

Research output: Contribution to journalArticle

76 Scopus citations

Incidence and risk factors for cognitive impairment no dementia and mild cognitive impairment in African Americans

Unverzagt, F. W., Ogunniyi, A., Taler, V., Gao, S., Lane, K. A., Baiyewu, O., Gureje, O., Smith-Gamble, V., Hake, A., Hendrie, H. C. & Hall, K. S., Jan 1 2011, In : Alzheimer disease and associated disorders. 25, 1, p. 4-10 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Weight loss and incident dementia in elderly Yoruba Nigerians: A 10-year follow-up study

Ogunniyi, A., Gao, S., Unverzagt, F. W., Baiyewu, O., Gureje, O., Nguyen, J. T., Smith-Gamble, V., Murrell, J. R., Hake, A. M., Hall, K. S. & Hendrie, H. C., Apr 1 2011, In : International Psychogeriatrics. 23, 3, p. 387-394 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2012

Connecting research discovery with care delivery in dementia: The development of the Indianapolis Discovery Network for Dementia

Boustani, M. A., Frame, A., Munger, S., Healey, P., Westlund, J., Farlow, M., Hake, A., Austrom, M. G., Shepard, P., Bubp, C., Azar, J., Nazir, A., Adams, N., Campbell, N. L., Chehresa, A. & Dexter, P., Nov 15 2012, In : Clinical interventions in aging. 7, p. 509-516 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Dementia

Hake, A. & Farlow, M., Oct 22 2012, Practical Neurology: Fourth Edition. Wolters Kluwer Health Pharma Solutions (Europe) Ltd, p. 488-495 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Homocysteine levels and dementia risk in Yoruba and African Americans

Hendrie, H. C., Baiyewu, O., Lane, K. A., Purnell, C., Gao, S., Hake, A., Ogunniyi, A., Gureje, O., Unverzagt, F. W., Murrell, J., Deeg, M. A. & Hall, K., Nov 1 2013, In : International Psychogeriatrics. 25, 11, p. 1859-1866 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

APOE ε4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba

Hendrie, H. C., Murrell, J., Baiyewu, O., Lane, K. A., Purnell, C., Ogunniyi, A., Unverzagt, F. W., Hall, K., Callahan, C. M., Saykin, A. J., Gureje, O., Hake, A., Foroud, T. & Gao, S., Jun 2014, In : International Psychogeriatrics. 26, 6, p. 977-985 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Cognitive function, body mass index and mortality in a rural elderly Chinese cohort

Gao, S., Jin, Y., Unverzagt, F. W., Cheng, Y., Su, L., Wang, C., Ma, F., Hake, A. M., Kettler, C., Chen, C., Liu, J., Bian, J., Li, P., Murrell, J. R., Clark, D. O. & Hendrie, H. C., Jan 1 2014, In : Archives of Public Health. 72, 1, 9.

Research output: Contribution to journalArticle

9 Scopus citations

Comparison of neuroimaging modalities for the prediction of conversion from mild cognitive impairment to alzheimer's dementia

Trzepacz, P. T., Yu, P., Sun, J., Schuh, K., Case, M., Witte, M. M., Hochstetler, H. & Hake, A., Jan 1 2014, In : Neurobiology of Aging. 35, 1, p. 143-151 9 p.

Research output: Contribution to journalArticle

85 Scopus citations
39 Scopus citations

The relationship between cholesterol and cognitive function is homocysteine-dependent

Cheng, Y., Jin, Y., Unverzagt, F. W., Su, L., Yang, L., Ma, F., Hake, A. M., Kettler, C., Chen, C., Liu, J., Bian, J., Li, P., Murrell, J. R., Hendrie, H. C. & Gao, S., 2014, In : Clinical interventions in aging. 9, p. 1823-1829 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2015

Alzheimer's disease progression by geographical region in a clinical trial setting

Henley, D. B., Dowsett, S. A., Chen, Y. F., Liu-Seifert, H., Grill, J. D., Doody, R. S., Aisen, P., Raman, R., Miller, D. S., Hake, A. M. & Cummings, J., Jun 25 2015, In : Alzheimer's Research and Therapy. 7, 1, 43.

Research output: Contribution to journalArticle

14 Scopus citations

Clinical use of amyloid-positron emission tomography neuroimaging: Practical and bioethical considerations

Witte, M. M., Foster, N. L., Fleisher, A. S., Williams, M. M., Quaid, K., Wasserman, M., Hunt, G., Roberts, J. S., Rabinovici, G. D., Levenson, J. L., Hake, A. M., Hunter, C. A., Van Campen, L. E., Pontecorvo, M. J., Hochstetler, H. M., Tabas, L. B. & Trzepacz, P. T., Sep 1 2015, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 1, 3, p. 358-367 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Cognitive and Functional Decline in Patients with Mild Alzheimer Dementia with or Without Comorbid Diabetes

Ascher-Svanum, H., Chen, Y. F., Hake, A., Kahle-Wrobleski, K., Schuster, D., Kendall, D. & Heine, R. J., Jun 18 2015, In : Clinical Therapeutics. 37, 6, p. 1195-1205 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Comparing recruitment, retention, and safety reporting among geographic regions in multinational Alzheimer's disease clinical trials

Grill, J. D., Raman, R., Ernstrom, K., Aisen, P., Dowsett, S. A., Chen, Y. F., Liu-Seifert, H., Hake, A. M., Miller, D. S., Doody, R. S., Henley, D. B. & Cummings, J. L., Jun 25 2015, In : Alzheimer's Research and Therapy. 7, 1, 39.

Research output: Contribution to journalArticle

11 Scopus citations

Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

Alzheimer's Disease Neuroimaging Initiative, May 19 2015, In : Nature communications. 6, 6760.

Research output: Contribution to journalArticle

113 Scopus citations

Florbetapir positron emission tomography and cerebrospinal fluid biomarkers

Alzheimer's Disease Neuroimaging Initiative, Aug 1 2015, In : Alzheimer's and Dementia. 11, 8, p. 986-993 8 p., 1970.

Research output: Contribution to journalArticle

12 Scopus citations

Selenium level and Dyslipidemia in rural elderly Chinese

Su, L., Gao, S., Unverzagt, F., Cheng, Y., Hake, A., Xin, P., Chen, C., Liu, J., Ma, F., Bian, J., Li, P. & Jin, Y., Sep 18 2015, In : PLoS One. 10, 9, e0136706.

Research output: Contribution to journalArticle

12 Scopus citations

Statin use, incident dementia and Alzheimer disease in elderly African Americans

Hendrie, H. C., Hake, A., Lane, K., Purnell, C., Unverzagt, F., Smith-Gamble, V., Murrell, J., Ogunniyi, A., Baiyewu, O., Callahan, C., Saykin, A., Taylor, S., Hall, K. & Gao, S., Jun 1 2015, In : Ethnicity and Disease. 25, 3, p. 345-354 10 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

The association between selenium and lipid levels: A longitudinal study in rural elderly Chinese

Chen, C., Jin, Y., Unverzagt, F. W., Cheng, Y., Hake, A. M., Liang, C., Ma, F., Su, L., Liu, J., Bian, J., Li, P. & Gao, S., Jan 1 2015, In : Archives of Gerontology and Geriatrics. 60, 1, p. 147-152 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Amyloid-related imaging abnormalities from trials of solanezumab for Alzheimer's disease

Carlson, C., Siemers, E., Hake, A., Case, M., Hayduk, R., Suhy, J., Oh, J. & Barakos, J., 2016, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2, p. 75-85 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults

Alzheimer's Disease Neuroimaging Initiative, Jun 2016, In : JAMA Neurology. 73, 6, p. 721-732 12 p.

Research output: Contribution to journalArticle

104 Scopus citations

Dementia incidence declined in African-Americans but not in Yoruba

Gao, S., Ogunniyi, A., Hall, K. S., Baiyewu, O., Unverzagt, F. W., Lane, K. A., Murrell, J. R., Gureje, O., Hake, A. M. & Hendrie, H. C., Mar 1 2016, In : Alzheimer's and Dementia. 12, 3, p. 244-251 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

The Alzheimer's Disease Neuroimaging Initiative, Jun 21 2016, In : Nature communications. 7, 11934.

Research output: Contribution to journalArticle

291 Scopus citations

Effect of diabetes on caregiver burden in an observational study of individuals with Alzheimer's disease

Lebrec, J., Ascher-Svanum, H., Chen, Y. F., Reed, C., Kahle-Wrobleski, K., Hake, A. M., Raskin, J., Naderali, E., Schuster, D., Heine, R. J. & Kendall, D. M., May 3 2016, In : BMC Geriatrics. 16, 1, 93.

Research output: Contribution to journalArticle

6 Scopus citations

Longitudinal association between selenium levels and hypertension in a rural elderly Chinese cohort

Su, L., Jin, Y., Unverzagt, F. W., Liang, C., Cheng, Y., Hake, A. M., Kuruppu, D., Ma, F., Liu, J., Chen, C., Bian, J., Li, P. & Gao, S., Dec 1 2016, In : Journal of Nutrition, Health and Aging. 20, 10, p. 983-988 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Nail Selenium Level and Diabetes in Older People in Rural China

SU, L. Q., JIN, Y. L., Unverzagt, F., CHENG, Y. B., Hake, A., RAN, L., MA, F., LIU, J. Y., CHEN, C., BIAN, J. C., WU, X. P. & Gao, S., Nov 1 2016, In : Biomedical and Environmental Sciences. 29, 11, p. 818-824 7 p.

Research output: Contribution to journalLetter

7 Scopus citations
2017

Assessing quality of life in Alzheimer's disease: Implications for clinical trials

Kahle-Wrobleski, K., Ye, W., Henley, D., Hake, A. M., Siemers, E., Chen, Y. F. & Liu-Seifert, H., 2017, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 6, p. 82-90 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease

Alzheimer's Disease Neuroimaging Initiative, May 2017, In : JAMA Neurology. 74, 5, p. 557-566 10 p.

Research output: Contribution to journalArticle

201 Scopus citations

Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features

Singanamalli, A., Wang, H., Madabhushi, A., Weiner, M., Aisen, P., Petersen, R., Jack, C., Jagust, W., Trojanowki, J., Toga, A., Beckett, L., Green, R., Saykin, A., Morris, J., Shaw, L., Kaye, J., Quinn, J., Silbert, L., Lind, B., Carter, R. & 221 others, Dolen, S., Schneider, L., Pawluczyk, S., Beccera, M., Teodoro, L., Spann, B., Brewer, J., Vanderswag, H., Fleisher, A., Heidebrink, J., Lord, J., Mason, S., Albers, C., Knopman, D., Johnson, K., Doody, R., Villanueva-Meyer, J., Chowdhury, M., Rountree, S., Dang, M., Stern, Y., Honig, L., Bell, K., Ances, B., Carroll, M., Creech, M., Franklin, E., Mintun, M., Schneider, S., Oliver, A., Marson, D., Griffith, R., Clark, D., Geldmacher, D., Brockington, J., Roberson, E., Natelson Love, M., Grossman, H., Mitsis, E., Shah, R., Detoledo-Morrell, L., Duara, R., Varon, D., Greig, M., Roberts, P., Albert, M., Onyike, C., D'Agostino, D., Kielb, S., Galvin, J., Cerbone, B., Michel, C., Pogorelec, D., Rusinek, H., De Leon, M., Glodzik, L., De Santi, S., Doraiswamy, P., Petrella, J., Borges-Neto, S., Wong, T., Coleman, E., Smith, C., Jicha, G., Hardy, P., Sinha, P., Oates, E., Conrad, G., Porsteinsson, A., Goldstein, B., Martin, K., Makino, K., Ismail, M., Brand, C., Mulnard, R., Thai, G., Mc-Adams-Ortiz, C., Womack, K., Mathews, D., Quiceno, M., Levey, A., Lah, J., Cellar, J., Burns, J., Swerdlow, R., Brooks, W., Apostolova, L., Tingus, K., Woo, E., Silverman, D., Lu, P., Bartzokis, G., Graff-Radford, N., Parfitt, F., Kendall, T., Johnson, H., Farlow, M., Marie Hake, A., Matthews, B., Brosch, J., Herring, S., Hunt, C., Dyck, C., Carson, R., MacAvoy, M., Varma, P., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Robin Hsiung, G. Y., Feldman, H., Mudge, B., Assaly, M., Finger, E., Pasternack, S., Rachisky, I., Trost, D., Kertesz, A., Bernick, C., Munic, D., Mesulam, M. M., Lipowski, K., Weintraub, S., Bonakdarpour, B., Kerwin, D., Wu, C. K., Johnson, N., Sadowsky, C., Villena, T., Scott Turner, R., Johnson, K., Reynolds, B., Sperling, R., Johnson, K., Marshall, G., Yesavage, J., Taylor, J., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M., Belden, C., Jacobson, S., Sirrel, S., Kowall, N., Killiany, R., Budson, A., Norbash, A., Lynn Johnson, P., Obisesan, T., Wolday, S., Allard, J., Lerner, A., Ogrocki, P., Tatsuoka, C., Fatica, P., Fletcher, E., Maillard, P., Olichney, J., Decarli, C., Carmichael, O., Kittur, S., Borrie, M., Lee, T. Y., Robbartha, Johnson, S., Asthana, S., Carlsson, C., Potkin, S., Preda, A., Nguyen, D., Tariot, P., Burke, A., Trncic, N., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D., Kataki, M., Adeli, A., Zimmerman, E., Celmins, D., Brown, A., Pearlson, G., Blank, K., Anderson, K., Flashman, L., Seltzer, M., Hynes, M., Santulli, R., Sink, K., Gordineer, L., Williamson, J., Garg, P., Watkins, F., Ott, B., Querfurth, H., Tremont, G., Salloway, S., Malloy, P., Correia, S., Rosen, H., Miller, B., Perry, D., Mintzer, J., Spicer, K., Bachman, D., Pomara, N., Hernando, R., Sarrael, A., Relkin, N., Chaing, G., Lin, M., Ravdin, L., Smith, A., Ashok Raj, B. & Fargher, K., Dec 1 2017, In : Scientific reports. 7, 1, 8137.

Research output: Contribution to journalArticle

3 Scopus citations
3 Scopus citations