Anna De Paoli-Roach

  • 7733 Citations
  • 50 h-Index
1974 …2020

Research output per year

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Publications

  • 7733 Citations
  • 50 h-Index
  • 144 Article
  • 3 Chapter
  • 3 Comment/debate
  • 2 Review article
Article

Abnormal cardiac development in the absence of heart glycogen

Pederson, B. A., Chen, H., Schroeder, J. M., Shou, W., DePaoli-Roach, A. A. & Roach, P. J., Aug 1 2004, In : Molecular and cellular biology. 24, 16, p. 7179-7187 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

Abnormal metabolism of glycogen phosphate as a cause for Lafora disease

Tagliabracci, V. S., Girard, J. M., Segvich, D., Meyer, C., Turnbull, J., Zhao, X., Minassian, B. A., DePaoli-Roach, A. A. & Roach, P. J., Dec 5 2008, In : Journal of Biological Chemistry. 283, 49, p. 33816-33825 10 p.

Research output: Contribution to journalArticle

117 Scopus citations

Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry

Young, L. E. A., Brizzee, C. O., Macedo, J. K. A., Murphy, R. D., Contreras, C. J., DePaoli-Roach, A. A., Roach, P. J., Gentry, M. S. & Sun, R. C., Feb 15 2020, In : Carbohydrate Polymers. 230, 115651.

Research output: Contribution to journalArticle

1 Scopus citations

Age-dependent changes in the sensitivity of the rat to a diabetogenic agent (Streptozotocin)

Masiello, P., de Paoli, A. & Bergamini, E., Mar 1975, In : Endocrinology. 96, 3, p. 787-789 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice

Savage, D. B., Zhai, L., Ravikumar, B., Cheol, S. C., Snaar, J. E., McGuire, A. C., Wou, S. E., Medina-Gomez, G., Kim, S., Bock, C. B., Segvich, D. M., Vidal-Puig, A., Wareham, N. J., Shulman, G. I., Karpe, F., Taylor, R., Pederson, B. A., Roach, P. J., O'Rahilly, S. & DePaoli-Roach, A. A., Jan 2008, In : PLoS Medicine. 5, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

A protein phosphatase-1γ1 isoform selectivity determinant in dendritic spine-associated neurabin

Carmody, L. C., Bauman, P. A., Bass, M. A., Mavila, N., DePaoli-Roach, A. A. & Colbran, R. J., May 21 2004, In : Journal of Biological Chemistry. 279, 21, p. 21714-21723 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Basis for MAP4 dephosphorylation-related microtubule network densification in pressure overload cardiac hypertrophy

Cheng, G., Takahashi, M., Shunmugavel, A., Wallenborn, J. G., DePaoli-Roach, A. A., Gergs, U., Neumann, J., Kuppuswamy, D., Menick, D. R. & Cooper IV, G., Dec 3 2010, In : Journal of Biological Chemistry. 285, 49, p. 38125-38140 16 p.

Research output: Contribution to journalArticle

19 Scopus citations
54 Scopus citations

Ca2+-stimulated phosphorylation of muscle glycogen synthase by phosphorylase b kinase

Roach, P. J., DePaoli-Roach, A. A. & Larner, J., Jan 1 1978, In : Journal of Cyclic Nucleotide Research. 4, 4, p. 245-257 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

Calcium and calmodulin activation of muscle phosphorylase kinase. Effect of tryptic proteolysis

Depaoli-Roach, A. A., Gibbs, J. B. & Roach, P. J., Sep 15 1979, In : FEBS Letters. 105, 2, p. 321-324 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

Calmodulin-stimulated glycogen synthase kinase from rabbit liver

Ahmad, Z., DePaoli-Roach, A. A. & Roach, P. J., Jan 1 1982, In : Federation Proceedings. 41, 4, p. No. 3515

Research output: Contribution to journalArticle

Casein kinase Iγ subfamily: Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes

Zhai, L., Graves, P. R., Robinson, L. C., Italiano, M., Culbertson, M. R., Rowles, J., Cobb, M. H., DePaoli-Roach, A. A. & Roach, P. J., May 26 1995, In : Journal of Biological Chemistry. 270, 21, p. 12717-12724 8 p.

Research output: Contribution to journalArticle

Open Access
88 Scopus citations

CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: Identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase

Healy, A. M., Zolnierowicz, S., Stapleton, A. E., Goebl, M., Depaoli-Roach, A. A. & Pringle, J. R., Nov 1991, In : Molecular and cellular biology. 11, 11, p. 5767-5780 14 p.

Research output: Contribution to journalArticle

Open Access
221 Scopus citations

Cellular mechanisms regulating protein phosphatase-1. A key functional interaction between inhibitor-2 and the type 1 protein phosphatase catalytic subunit

Connor, J. H., Frederick, D., Huang, H. B., Yang, J., Helps, N. R., Cohen, P. T. W., Nairn, A. C., DePaoli-Roach, A., Tatchell, K. & Shenolikar, S., Jun 23 2000, In : Journal of Biological Chemistry. 275, 25, p. 18670-18675 6 p.

Research output: Contribution to journalArticle

50 Scopus citations
49 Scopus citations

Characterization of rabbit skeletal muscle glycogenin. Tyrosine 194 is essential for function

Cao, Y., Mahrenholz, A. M., DePaoli-Roach, A. A. & Roach, P. J., Jan 1 1993, In : Journal of Biological Chemistry. 268, 20, p. 14687-14693 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Characterization of the PP2Aα gene mutation in okadaic acid-resistant variants of CHO-K1 cells

Shima, H., Tohda, H., Aonuma, S., Nakayasu, M., Depaoli-Roach, A. A., Sugimura, T. & Nagao, M., Sep 27 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 20, p. 9267-9271 5 p.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations

Control of glycogen synthase phosphorylation in isolated rat hepatocytes by epinephrine, vasopressin and glucagon

CIUDAD, C., CAMICI, M., AHMAD, Z., WANG, Y., DePAOLI‐ROACH, A. A. & ROACH, P. J., Aug 1984, In : European Journal of Biochemistry. 142, 3, p. 511-520 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Control of mammalian glycogen synthase by PAS kinase

Wilson, W. A., Skurat, A. V., Probst, B., De Paoli-Roach, A., Roach, P. J. & Rutter, J., Nov 15 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 46, p. 16596-16601 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B′ subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest

Bennin, D. A., Arachchige Don, A. S., Brake, T., McKenzie, J. L., Rosenbaum, H., Ortiz, L., Depaoli-Roach, A. A. & Horne, M. C., Jul 26 2002, In : Journal of Biological Chemistry. 277, 30, p. 27449-27467 19 p.

Research output: Contribution to journalArticle

159 Scopus citations

Decreased protein phosphatase 2A activity in hippocampal long-term potentiation

Fukunaga, K., Muller, D., Ohmitsu, M., Bakó, E., DePaoli-Roach, A. A. & Miyamoto, E., Jan 29 2000, In : Journal of Neurochemistry. 74, 2, p. 807-817 11 p.

Research output: Contribution to journalArticle

71 Scopus citations

Dephosphorylation of myosin by the catalytic subunit of a type-2 phosphatase produces relaxation of chemically skinned uterine smooth muscle

Haeberle, J. R., Hathaway, D. R. & DePaoli-Roach, A. A., Dec 1 1985, In : Journal of Biological Chemistry. 260, 18, p. 9965-9968 4 p.

Research output: Contribution to journalArticle

40 Scopus citations

Dephosphorylation of Sp1 by protein phosphatase 1 is involved in the glucose-mediated activation of the acetyl-CoA carboxylase gene

Daniel, S., Zhang, S., DePaoli-Roach, A. A. & Kim, K. H., Jul 2 1996, In : Journal of Biological Chemistry. 271, 25, p. 14692-14697 6 p.

Research output: Contribution to journalArticle

130 Scopus citations

Different changes of glycogen content in rat muscle denervated by different procedures.

De Paoli, A. A., Masiello, P., Villa-Moruzzi, E. & Bergamini, E., Oct 15 1979, In : Bollettino della Societa italiana di biologia sperimentale. 55, 19, p. 1956-1959 4 p.

Research output: Contribution to journalArticle

Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase

Tang, B., Frasinyuk, M. S., Chikwana, V. M., Mahalingan, K. K., Morgan, C. A., Segvich, D. M., Bondarenko, S. P., Mrug, G. P., Wyrebek, P., Watt, D. S., Depaoli-Roach, A. A., Roach, P. J. & Hurley, T. D., Apr 9 2020, In : Journal of Medicinal Chemistry. 63, 7, p. 3538-3551 14 p.

Research output: Contribution to journalArticle

Distinctive regulatory and metabolic properties of glycogen-targeting subunits of protein phosphatase-1 (PTG, G(L), G(M)/R(G1)) expressed in hepatocytes

Gasa, R., Jensen, P. B., Berman, H. K., Brady, M. J., Depaoli-Roach, A. A. & Newgard, C. B., Aug 25 2000, In : Journal of Biological Chemistry. 275, 34, p. 26396-26403 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Diversity in the Regulatory B-Subunits of Protein Phosphatase 2A: Identification of a Novel Isoform Highly Expressed in Brain

Zolnierowicz, S., Csortos, C., Bondor, J., Verin, A., Mumby, M. C. & DePaoli-Roach, A. A., Oct 1 1994, In : Biochemistry. 33, 39, p. 11858-11867 10 p.

Research output: Contribution to journalArticle

92 Scopus citations

Domains of phosphatase inhibitor-2 involved in the control of the ATP-Mg- dependent protein phosphatase

Park, I. K. & DePaoli-Roach, A. A., Jan 1 1994, In : Journal of Biological Chemistry. 269, 46, p. 28919-28928 10 p.

Research output: Contribution to journalArticle

60 Scopus citations

Early changes of protein-kinase (glycogen-synthetase kinase) in denervated muscle

Bergamini, E. & De Paoli, A. A., Jul 1974, In : Experimental Neurology. 44, 1, p. 96-102 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Early effects of the administration of streptozotocin on muscle glycogen

de Paoli, A. A., Masiello, P. & Bergamini, E., Apr 15 1976, In : Biochemical Pharmacology. 25, 8, p. 933-935 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effect of denervation on muscle glycogen synthase kinase activity

DePaoli-Roach, A. A., Villar-Palasi, C. & Bergamini, E., Nov 1978, In : Experimental Neurology. 62, 2, p. 494-496 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2

Kirchhefer, U., Baba, H. A., Bokník, P., Breeden, K. M., Mavila, N., Brüchert, N., Justus, I., Matus, M., Schmitz, W., DePaoli-Roach, A. A. & Neumann, J., Oct 1 2005, In : Cardiovascular research. 68, 1, p. 98-108 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase

Pathak, A., Del Monte, F., Zhao, W., Schultz, J. E., Lorenz, J. N., Bodi, I., Weiser, D., Hahn, H., Carr, A. N., Syed, F., Mavila, N., Jha, L., Qian, J., Marreez, Y., Chen, G., McGraw, D. W., Heist, E. K., Guerrero, J. L., DePaoli-Roach, A. A., Hajjar, R. J. & 1 others, Kranias, E. G., Apr 15 2005, In : Circulation research. 96, 7, p. 756-766 11 p.

Research output: Contribution to journalArticle

174 Scopus citations
1 Scopus citations

Epinephrine control of multiple phosphorylation sites of glycogen synthase in mouse diaphragms

Lee, F. T., Ahmad, Z., DePaoli-Roach, A. A. & Roach, P. J., Jan 1 1985, In : Federation Proceedings. 44, 3, p. No. 1590

Research output: Contribution to journalArticle

Exercise capacity of mice genetically lacking muscle glycogen synthase: In mice, muscle glycogen is not essential for exercise

Pederson, B. A., Cope, C. M., Schroeder, J. M., Smith, M. W., Irimia, J. M., Thurberg, B. L., DePaoli-Roach, A. A. & Roach, P. J., Apr 29 2005, In : Journal of Biological Chemistry. 280, 17, p. 17260-17265 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

Fluorescence Studies on the Interaction of Inhibitor 2 and Okadaic Acid with the Catalytic Subunit of Type 1 Phosphoprotein Phosphatases

Picking, W. D., Kudlicki, W., Kramer, G., Hardesty, B., Vandenheede, J. R., Merlevede, W., Park, I. K. & DePaoli-Roach, A., Oct 1 1991, In : Biochemistry. 30, 42, p. 10280-10287 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Generation by insulin of a chemical mediator that controls protein phosphorylation and dephosphorylation

Larner, J., Galasko, G., Cheng, K., DePaoli-Roach, A. A., Huang, L., Daggy, P. & Kellogg, J., Jan 1 1979, In : Science. 206, 4425, p. 1408-1410 3 p.

Research output: Contribution to journalArticle

224 Scopus citations

Gene structure and expression of the targeting subunit, RGL, of the muscle-specific glycogen-associated type 1 protein phosphatase, PP1G

Lannér, C., Suzuki, Y., Bi, C. B., Zhang, H., Cooper, L. D., Bowker-Kinley, M. M., DePaoli-Roach, A. A. & Suzuki, Y., Apr 1 2001, In : Archives of Biochemistry and Biophysics. 388, 1, p. 135-145 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Genetic depletion of the malin e3 ubiquitin ligase in mice leads to Lafora bodies and the accumulation of insoluble laforin

DePaoli-Roach, A. A., Tagliabracci, V. S., Segvich, D. M., Meyer, C. M., Irimia, J. M. & Roach, P. J., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25372-25381 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

Glucose metabolism in mice lacking muscle glycogen synthase

Pederson, B. A., Schroeder, J. M., Parker, G. E., Smith, M. W., DePaoli-Roach, A. A. & Roach, P. J., Dec 1 2005, In : Diabetes. 54, 12, p. 3466-3473 8 p.

Research output: Contribution to journalArticle

79 Scopus citations

Glycogen metabolism and signal transduction in mammals and yeast

Roach, P. J., Cao, Y., Corbett, C. A., DePaoli-Roach, A. A., Farkas, I., Fiol, C. J., Flotow, H., Graves, P. R., Hardy, T. A., Hrubey, T. W., Viskupic, E. & Zhang, W., 1991, In : Advances in Enzyme Regulation. 31, C, p. 101-120 20 p.

Research output: Contribution to journalArticle

15 Scopus citations

Glycogen metabolism in tissues from a mouse model of Lafora disease

Wang, W., Lohi, H., Skurat, A. V., DePaoli-Roach, A. A., Minassian, B. A. & Roach, P. J., Jan 15 2007, In : Archives of Biochemistry and Biophysics. 457, 2, p. 264-269 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease

DePaoli-Roach, A. A., Contreras, C. J., Segvich, D. M., Heiss, C., Ishihara, M., Azadi, P. & Roach, P. J., Jan 1 2015, In : Journal of Biological Chemistry. 290, 2, p. 841-850 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Glycogen synthase kinase-3β is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation

Wang, Q. M., Fiol, C. J., DePaoli-Roach, A. A. & Roach, P. J., May 20 1994, In : Journal of Biological Chemistry. 269, 20, p. 14566-14574 9 p.

Research output: Contribution to journalArticle

238 Scopus citations
50 Scopus citations
9 Scopus citations
20 Scopus citations

High complexity in the expression of the B′ subunit of protein phosphatase 2A0: Evidence for the existence of at least seven novel isoforms

Csortos, C., Zolnierowicz, S., Bakó, E., Durbin, S. D. & DePaoli-Roach, A. A., Feb 2 1996, In : Journal of Biological Chemistry. 271, 5, p. 2578-2588 11 p.

Research output: Contribution to journalArticle

Open Access
154 Scopus citations