Anna De Paoli-Roach

  • 7721 Citations
  • 50 h-Index
1974 …2020

Research output per year

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Publications

  • 7721 Citations
  • 50 h-Index
  • 143 Article
  • 3 Chapter
  • 3 Comment/debate
  • 2 Review article
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Article
2020

Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry

Young, L. E. A., Brizzee, C. O., Macedo, J. K. A., Murphy, R. D., Contreras, C. J., DePaoli-Roach, A. A., Roach, P. J., Gentry, M. S. & Sun, R. C., Feb 15 2020, In : Carbohydrate Polymers. 230, 115651.

Research output: Contribution to journalArticle

1 Scopus citations

Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase

Tang, B., Frasinyuk, M. S., Chikwana, V. M., Mahalingan, K. K., Morgan, C. A., Segvich, D. M., Bondarenko, S. P., Mrug, G. P., Wyrebek, P., Watt, D. S., Depaoli-Roach, A. A., Roach, P. J. & Hurley, T. D., Apr 9 2020, In : Journal of Medicinal Chemistry. 63, 7, p. 3538-3551 14 p.

Research output: Contribution to journalArticle

2019

Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure

Cordero, P., Parikh, V. N., Chin, E. T., Erbilgin, A., Gloudemans, M. J., Shang, C., Huang, Y., Chang, A. C., Smith, K. S., Dewey, F., Zaleta, K., Morley, M., Brandimarto, J., Glazer, N., Waggott, D., Pavlovic, A., Zhao, M., Moravec, C. S., Tang, W. H. W., Skreen, J. & 15 others, Malloy, C., Hannenhalli, S., Li, H., Ritter, S., Li, M., Bernstein, D., Connolly, A., Hakonarson, H., Lusis, A. J., Margulies, K. B., Depaoli-Roach, A. A., Montgomery, S. B., Wheeler, M. T., Cappola, T. & Ashley, E. A., Dec 1 2019, In : Nature communications. 10, 1, 2760.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion

Brewer, M. K., Uittenbogaard, A., Austin, G. L., Segvich, D. M., DePaoli-Roach, A., Roach, P. J., McCarthy, J. J., Simmons, Z. R., Brandon, J. A., Zhou, Z., Zeller, J., Young, L. E. A., Sun, R. C., Pauly, J. R., Aziz, N. M., Hodges, B. L., McKnight, T. R., Armstrong, D. D. & Gentry, M. S., Oct 1 2019, In : Cell Metabolism. 30, 4, p. 689-705.e6

Research output: Contribution to journalArticle

7 Scopus citations
2017

Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice

Irimia, J. M., Meyer, C. M., Segvich, D. M., Surendran, S., Depaoli-Roach, A. A., Morral, N. & Roach, P. J., Jun 23 2017, In : Journal of Biological Chemistry. 292, 25, p. 10455-10464 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Novel method for detection of glycogen in cells

Skurat, A., Segvich, D. M., De Paoli-Roach, A. & Roach, P., May 1 2017, In : Glycobiology. 27, 5, p. 416-424 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Redox switch for the inhibited state of yeast glycogen synthase mimics regulation by phosphorylation

Mahalingan, K. K., Baskaran, S., Depaoli-Roach, A. A., Roach, P. J. & Hurley, T. D., Jan 1 2017, In : Biochemistry. 56, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Incorporation of phosphate into glycogen by glycogen synthase

Contreras, C. J., Segvich, D. M., Mahalingan, K., Chikwana, V. M., Kirley, T. L., Hurley, T. D., DePaoli-Roach, A. A. & Roach, P. J., May 1 2016, In : Archives of Biochemistry and Biophysics. 597, p. 21-29 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Protein targeting to glycogen is a master regulator of glycogen synthesis in astrocytes

Ruchti, E., Roach, P. J., DePaoli-Roach, A. A., Magistretti, P. J. & Allaman, I., Dec 1 2016, In : IBRO Reports. 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease

DePaoli-Roach, A. A., Contreras, C. J., Segvich, D. M., Heiss, C., Ishihara, M., Azadi, P. & Roach, P. J., Jan 1 2015, In : Journal of Biological Chemistry. 290, 2, p. 841-850 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice

Irimia, J. M., Tagliabracci, V. S., Meyer, C. M., Segvich, D. M., Depaoli-Roach, A. A. & Roach, P. J., Sep 11 2015, In : Journal of Biological Chemistry. 290, 37, p. 22686-22698 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Protein degradation and quality control in cells from laforin and malin knockout mice

Garyali, P., Segvich, D. M., Depaoli-Roach, A. A. & Roach, P. J., Jul 25 2014, In : Journal of Biological Chemistry. 289, 30, p. 20606-20614 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver

Ruiz, R., Jideonwo, V., Ahn, M., Surendran, S., Tagliabracci, V. S., Hou, Y., Gamble, A., Kerner, J., Irimia-Dominguez, J. M., Puchowicz, M. A., DePaoli-Roach, A., Hoppel, C., Roach, P. & Morral, N., Feb 28 2014, In : Journal of Biological Chemistry. 289, 9, p. 5510-5517 8 p.

Research output: Contribution to journalArticle

49 Scopus citations
2013

Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase

Chikwana, V. M., Khanna, M., Baskaran, S., Tagliabracci, V. S., Contreras, C. J., DePaoli-Roach, A., Roach, P. J. & Hurley, T. D., Dec 24 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 52, p. 20976-20981 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity

DePaoli-Roach, A. A., Segvich, D. M., Meyer, C. M., Rahimi, Y., Worby, C. A., Gentry, M. S. & Roach, P. J., Apr 1 2012, In : Human molecular genetics. 21, 7, p. 1604-1610 7 p., ddr598.

Research output: Contribution to journalArticle

16 Scopus citations
2011

Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen

Baskaran, S., Chikwana, V. M., Contreras, C. J., Davis, K. D., Wilson, W. A., DePaoli-Roach, A. A., Roach, P. J. & Hurley, T. D., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 33999-34006 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Phosphate incorporation during glycogen synthesis and Lafora disease

Tagliabracci, V. S., Heiss, C., Karthik, C., Contreras, C. J., Glushka, J., Ishihara, M., Azadi, P., Hurley, T. D., Depaoli-Roach, A. A. & Roach, P. J., Mar 2 2011, In : Cell Metabolism. 13, 3, p. 274-282 9 p.

Research output: Contribution to journalArticle

76 Scopus citations

PTG depletion removes lafora bodies and rescues the fatal epilepsy of lafora disease

Turnbull, J., DePaoli-Roach, A. A., Zhao, X., Cortez, M. A., Pencea, N., Tiberia, E., Piliguian, M., Roach, P. J., Wang, P., Ackerley, C. A. & Minassian, B. A., Apr 1 2011, In : PLoS Genetics. 7, 4, e1002037.

Research output: Contribution to journalArticle

66 Scopus citations
2010

Basis for MAP4 dephosphorylation-related microtubule network densification in pressure overload cardiac hypertrophy

Cheng, G., Takahashi, M., Shunmugavel, A., Wallenborn, J. G., DePaoli-Roach, A. A., Gergs, U., Neumann, J., Kuppuswamy, D., Menick, D. R. & Cooper IV, G., Dec 3 2010, In : Journal of Biological Chemistry. 285, 49, p. 38125-38140 16 p.

Research output: Contribution to journalArticle

19 Scopus citations

Genetic depletion of the malin e3 ubiquitin ligase in mice leads to Lafora bodies and the accumulation of insoluble laforin

DePaoli-Roach, A. A., Tagliabracci, V. S., Segvich, D. M., Meyer, C. M., Irimia, J. M. & Roach, P. J., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25372-25381 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice

Irimia, J. M., Meyer, C. M., Peper, C. L., Zhai, L., Bock, C. B., Previs, S. F., McGuinness, O. P., DePaoli-Roach, A. & Roach, P. J., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 12851-12861 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism

Jiang, S., Heller, B., Tagliabracci, V. S., Zhai, L., Irimia, J. M., DePaoli-Roach, A. A., Wells, C. D., Skurat, A. V. & Roach, P. J., Nov 5 2010, In : Journal of Biological Chemistry. 285, 45, p. 34960-34971 12 p.

Research output: Contribution to journalArticle

71 Scopus citations
49 Scopus citations
2009

Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A

Eckerdt, F., Pascreau, G., Phistry, M., Lewellyn, A. L., DePaoli-Roach, A. A. & Maller, J. L., Aug 1 2009, In : Cell Cycle. 8, 15, p. 2413-2419 7 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations
2008

Abnormal metabolism of glycogen phosphate as a cause for Lafora disease

Tagliabracci, V. S., Girard, J. M., Segvich, D., Meyer, C., Turnbull, J., Zhao, X., Minassian, B. A., DePaoli-Roach, A. A. & Roach, P. J., Dec 5 2008, In : Journal of Biological Chemistry. 283, 49, p. 33816-33825 10 p.

Research output: Contribution to journalArticle

117 Scopus citations

A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice

Savage, D. B., Zhai, L., Ravikumar, B., Cheol, S. C., Snaar, J. E., McGuire, A. C., Wou, S. E., Medina-Gomez, G., Kim, S., Bock, C. B., Segvich, D. M., Vidal-Puig, A., Wareham, N. J., Shulman, G. I., Karpe, F., Taylor, R., Pederson, B. A., Roach, P. J., O'Rahilly, S. & DePaoli-Roach, A. A., Jan 1 2008, In : PLoS Medicine. 5, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality

Brüchert, N., Mavila, N., Boknik, P., Baba, H. A., Fabritz, L., Gergs, U., Kirchhefer, U., Kirchhof, P., Matus, M., Schmitz, W., DePaoli-Roach, A. A. & Neumann, J., Oct 1 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 295, 4, p. H1539-H1546

Research output: Contribution to journalArticle

15 Scopus citations
2007

Glycogen metabolism in tissues from a mouse model of Lafora disease

Wang, W., Lohi, H., Skurat, A. V., DePaoli-Roach, A. A., Minassian, B. A. & Roach, P. J., Jan 15 2007, In : Archives of Biochemistry and Biophysics. 457, 2, p. 264-269 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo

Tagliabracci, V. S., Turnbull, J., Wang, W., Girard, J. M., Zhao, X., Skurat, A. V., Delgado-Escueta, A. V., Minassian, B. A., DePaoli-Roach, A. A. & Roach, P. J., Dec 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19262-19266 5 p.

Research output: Contribution to journalArticle

136 Scopus citations

Structural basis for regulation of protein phosphatase 1 by inhibitor-2

Hurley, T. D., Yang, J., Zhang, L., Goodwin, K. D., Zou, Q., Cortese, M., Dunker, A. K. & DePaoli-Roach, A. A., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 28874-28883 10 p.

Research output: Contribution to journalArticle

128 Scopus citations
2006

Relationship between glycogen accumulation and the laforin dual specificity phosphatase

Wang, W., Parker, G. E., Skurat, A. V., Raben, N., DePaoli-Roach, A. A. & Roach, P. J., Nov 24 2006, In : Biochemical and Biophysical Research Communications. 350, 3, p. 588-592 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation

Jeoung, N. H., Wu, P., Joshi, M. A., Jaskiewicz, J., Bock, C. B., DePaoli-Roach, A. A. & Harris, R. A., Aug 1 2006, In : Biochemical Journal. 397, 3, p. 417-425 9 p.

Research output: Contribution to journalArticle

87 Scopus citations
2005

Control of mammalian glycogen synthase by PAS kinase

Wilson, W. A., Skurat, A. V., Probst, B., De Paoli-Roach, A., Roach, P. J. & Rutter, J., Nov 15 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 46, p. 16596-16601 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2

Kirchhefer, U., Baba, H. A., Bokník, P., Breeden, K. M., Mavila, N., Brüchert, N., Justus, I., Matus, M., Schmitz, W., DePaoli-Roach, A. A. & Neumann, J., Oct 1 2005, In : Cardiovascular research. 68, 1, p. 98-108 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase

Pathak, A., Del Monte, F., Zhao, W., Schultz, J. E., Lorenz, J. N., Bodi, I., Weiser, D., Hahn, H., Carr, A. N., Syed, F., Mavila, N., Jha, L., Qian, J., Marreez, Y., Chen, G., McGraw, D. W., Heist, E. K., Guerrero, J. L., DePaoli-Roach, A. A., Hajjar, R. J. & 1 others, Kranias, E. G., Apr 15 2005, In : Circulation research. 96, 7, p. 756-766 11 p.

Research output: Contribution to journalArticle

174 Scopus citations

Exercise capacity of mice genetically lacking muscle glycogen synthase: In mice, muscle glycogen is not essential for exercise

Pederson, B. A., Cope, C. M., Schroeder, J. M., Smith, M. W., Irimia, J. M., Thurberg, B. L., DePaoli-Roach, A. A. & Roach, P. J., Apr 29 2005, In : Journal of Biological Chemistry. 280, 17, p. 17260-17265 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

Glucose metabolism in mice lacking muscle glycogen synthase

Pederson, B. A., Schroeder, J. M., Parker, G. E., Smith, M. W., DePaoli-Roach, A. A. & Roach, P. J., Dec 1 2005, In : Diabetes. 54, 12, p. 3466-3473 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Mice with elevated muscle glycogen stores do not have improved exercise performance

Pederson, B. A., Cope, C. R., Irimia, J. M., Schroeder, J. M., Thurberg, B. L., DePaoli-Roach, A. A. & Roach, P. J., Jun 3 2005, In : Biochemical and Biophysical Research Communications. 331, 2, p. 491-496 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
2004

Abnormal cardiac development in the absence of heart glycogen

Pederson, B. A., Chen, H., Schroeder, J. M., Shou, W., DePaoli-Roach, A. A. & Roach, P. J., Aug 1 2004, In : Molecular and cellular biology. 24, 16, p. 7179-7187 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

A protein phosphatase-1γ1 isoform selectivity determinant in dendritic spine-associated neurabin

Carmody, L. C., Bauman, P. A., Bass, M. A., Mavila, N., DePaoli-Roach, A. A. & Colbran, R. J., May 21 2004, In : Journal of Biological Chemistry. 279, 21, p. 21714-21723 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

PKC-α regulates cardiac contractility and propensity toward heart failure

Braz, J. C., Gregory, K., Pathak, A., Zhao, W., Sahin, B., Klevitsky, R., Kimball, T. F., Lorenz, J. N., Nairn, A. C., Liggett, S. B., Bodi, I., Wang, S., Schwartz, A., Lakatta, E. G., DePaoli-Roach, A. A., Robbins, J., Hewett, T. E., Bibb, J. A., Westfall, M. V., Kranias, E. G. & 1 others, Molkentin, J. D., Mar 1 2004, In : Nature Medicine. 10, 3, p. 248-254 7 p.

Research output: Contribution to journalArticle

449 Scopus citations
2003

Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase

Hurley, J. H., Zhang, S., Bye, L. S., Marshall, M. S., DePaoli-Roach, A. A., Guan, K., Fox, A. P. & Yu, L., Jun 9 2003, In : BMC Neuroscience. 4, 10.

Research output: Contribution to journalArticle

17 Scopus citations

Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator)

Isoda, T., Paolocci, N., Haghighi, K., Wang, C., Wang, Y., Georgakopoulos, D., Servillo, G., Della Fazia, M. A., Kranias, E. G., Depaoli-Roach, A. A., Sassone-Corsi, P. & Kass, D. A., Feb 1 2003, In : FASEB Journal. 17, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2002

Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B′ subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest

Bennin, D. A., Arachchige Don, A. S., Brake, T., McKenzie, J. L., Rosenbaum, H., Ortiz, L., Depaoli-Roach, A. A. & Horne, M. C., Jul 26 2002, In : Journal of Biological Chemistry. 277, 30, p. 27449-27467 19 p.

Research output: Contribution to journalArticle

159 Scopus citations
1 Scopus citations

Reversal of diet-induced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1

Gasa, R., Clark, C., Yang, R., Depaoli-Roach, A. A. & Newgard, C. B., Jan 11 2002, In : Journal of Biological Chemistry. 277, 2, p. 1524-1530 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Type 1 phosphatase, a negative regulator of cardiac function

Carr, A. N., Schmidt, A. G., Suzuki, Y., Del Monte, F., Sato, Y., Lanner, C., Breeden, K., Jing, S. L., Allen, P. B., Greengard, P., Yatani, A., Hoit, B. D., Grupp, I. L., Hajjar, R. J., DePaoli-Roach, A. A. & Kranias, E. G., Jun 5 2002, In : Molecular and cellular biology. 22, 12, p. 4124-4135 12 p.

Research output: Contribution to journalArticle

208 Scopus citations
2001

Gene structure and expression of the targeting subunit, RGL, of the muscle-specific glycogen-associated type 1 protein phosphatase, PP1G

Lannér, C., Suzuki, Y., Bi, C. B., Zhang, H., Cooper, L. D., Bowker-Kinley, M. M., DePaoli-Roach, A. A. & Suzuki, Y., Apr 1 2001, In : Archives of Biochemistry and Biophysics. 388, 1, p. 135-145 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase pp1g/rgl

Suzuki, Y., Lanner, C., Kim, J. H., Giuseppe Vilardo, P., Zhang, H., Yang, J., Cooper, L. D., Steele, M., Kennedy, A., Bock, C. B., Scrimgeour, A., Lawrence, J. & Depaoli-Roach, A. A., Apr 10 2001, In : Molecular and cellular biology. 21, 8, p. 2683-2694 12 p.

Research output: Contribution to journalArticle

121 Scopus citations

The Muscle-specific Protein Phosphatase PP1G/RGL(GM) Is Essential for Activation of Glycogen Synthase by Exercise

Aschenbach, W. G., Suzuki, Y., Breeden, K., Prats, C., Hirshman, M. F., Dufresne, S. D., Sakamoto, K., Vilardo, P. G., Steele, M., Kim, J. H., Jing, S. L., Goodyear, L. J. & DePaoli-Roach, A. A., Oct 26 2001, In : Journal of Biological Chemistry. 276, 43, p. 39959-39967 9 p.

Research output: Contribution to journalArticle

92 Scopus citations