Anthony Firulli

  • 3185 Citations
  • 33 h-Index
1989 …2020

Research output per year

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Publications

  • 3185 Citations
  • 33 h-Index
  • 60 Article
  • 8 Review article
  • 2 Editorial
  • 1 Chapter
2020

HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure

Firulli, B. A., George, R. M., Harkin, J., Toolan, K. P., Gao, H., Liu, Y., Zhang, W., Field, L. J., Liu, Y., Shou, W., Payne, R. M., Rubart-Von Der Lohe, M. & Firulli, A. B., Mar 1 2020, In : Cardiovascular research. 116, 3, p. 605-618 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects

Durbin, M. D., O'Kane, J., Lorentz, S., Firulli, A. B. & Ware, S. M., Aug 15 2020, In : Developmental Biology. 464, 2, p. 124-136 13 p.

Research output: Contribution to journalArticle

Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function

Vincentz, J. W., Firulli, B. A., Toolan, K. P., Arking, D. E., Sotoodehnia, N., Wan, J., Chen, P. S., De Gier-De Vries, C., Christoffels, V. M., Rubart-Von Der Lohe, M. & Firulli, A. B., 2020, (Accepted/In press) In : Circulation research. p. 575-589 15 p.

Research output: Contribution to journalArticle

Open Access
2019

Hand Factors in Cardiac Development

George, R. M. & Firulli, A. B., Jan 2019, In : Anatomical Record. 302, 1, p. 101-107 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Partially Penetrant Cardiac Neural Crest Defects in Hand1 Phosphomutant Mice: Dimer Choice That Is Not So Critical

Firulli, B. A. & Firulli, A. B., Oct 1 2019, In : Pediatric Cardiology. 40, 7, p. 1339-1344 6 p.

Research output: Contribution to journalArticle

Twist1 inactivation in Dmp1-expressing cells increases bone mass but does not affect the anabolic response to sclerostin neutralization

Lewis, K. J., Choi, R. B. J., Pemberton, E. Z., Bullock, W. A., Firulli, A. B. & Robling, A. G., Sep 2019, In : International journal of molecular sciences. 20, 18, 4427.

Research output: Contribution to journalArticle

Open Access
2018

Notch signaling regulates Hey2 expression in a spatiotemporal dependent manner during cardiac morphogenesis and trabecular specification

Miao, L., Li, J., Li, J., Tian, X., Lu, Y., Hu, S., Shieh, D., Kanai, R., Zhou, B. Y., Zhou, B., Liu, J., Firulli, A. B., Martin, J. F., Singer, H., Xin, H. & Wu, M., Dec 1 2018, In : Scientific reports. 8, 1, 2678.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis

Firulli, B. A., Milliar, H., Toolan, K. P., Harkin, J., Fuchs, R. K., Robling, A. G. & Firulli, A. B., Jan 1 2017, In : Development (Cambridge). 144, 13, p. 2480-2489 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function

Vincentz, J. W., Toolan, K. P., Zhang, W. & Firulli, A. B., Jul 2017, In : PLoS Genetics. 13, 7, e1006922.

Research output: Contribution to journalArticle

13 Scopus citations

Nkx2.5 regulates endothelin converting enzyme-1 during pharyngeal arch patterning

Iklé, J. M., Tavares, A. L. P., King, M., Ding, H., Colombo, S., Firulli, B. A., Firulli, A. B., Targoff, K. L., Yelon, D. & Clouthier, D. E., Mar 1 2017, In : Genesis. 55, 3, e23021.

Research output: Contribution to journalArticle

3 Scopus citations

The HAND1 frameshift A126FS mutation does not cause hypoplastic left heart syndrome in mice

Firulli, B. A., Toolan, K. P., Harkin, J., Millar, H., Pineda, S. & Firulli, A. B., Dec 1 2017, In : Cardiovascular research. 113, 14, p. 1732-1742 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap

Vincentz, J. W., Casasnovas, J. J., Barnes, R. M., Que, J., Clouthier, D. E., Wang, J. & Firulli, A. B., Jul 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 27, p. 7563-7568 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Single-Cell Lineage Tracing Reveals that Oriented Cell Division Contributes to Trabecular Morphogenesis and Regional Specification

Li, J., Miao, L., Shieh, D., Spiotto, E., Li, J., Zhou, B., Paul, A., Schwartz, R. J., Firulli, A. B., Singer, H. A., Huang, G. & Wu, M., Apr 5 2016, In : Cell Reports. 15, 1, p. 158-170 13 p.

Research output: Contribution to journalArticle

24 Scopus citations
2015

Structure-Function Studies of the bHLH Phosphorylation Domain of TWIST1 in Prostate Cancer Cells

Gajula, R. P., Chettiar, S. T., Williams, R. D., Nugent, K., Kato, Y., Wang, H., Malek, R., Taparra, K., Cades, J., Annadanam, A., Yoon, A. R., Fertig, E., Firulli, B. A., Mazzacurati, L., Burns, T. F., Firulli, A., An, S. S. & Tran, P. T., Jan 1 2015, In : Neoplasia. 17, 1, p. 16-31 16 p.

Research output: Contribution to journalArticle

16 Scopus citations
2014

Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis

Firulli, B. A., Fuchs, R. K., Vincentz, J. W., Clouthier, D. E. & Firulli, A. B., Aug 2014, In : Development (Cambridge). 141, 15, p. 3050-3061 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration

Schindler, Y. L., Garske, K. M., Wang, J., Firulli, B. A., Firulli, A. B., Poss, K. D. & Yelon, D., Aug 2014, In : Development (Cambridge). 141, 16, p. 3112-3122 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Hand2 Is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic Endocardium

VanDusen, N. J., Casanovas, J., Vincentz, J. W., Firulli, B. A., Osterwalder, M., Lopez-Rios, J., Zeller, R., Zhou, B., Grego-Bessa, J., DeLaPompa, J., Shou, W. & Firulli, A. B., Dec 24 2014, In : Cell Reports. 9, 6, p. 2071-2083 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death

VanDusen, N. J., Vincentz, J. W., Firulli, B. A., Howard, M. J., Rubart, M. & Firulli, A. B., Apr 15 2014, In : Developmental Biology. 388, 2, p. 149-158 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Recombinant neuregulin 1 does not activate cardiomyocyte DNA synthesis in normal or infarcted adult mice

Reuter, S., Soonpaa, M. H., Firulli, A. B., Chang, A. N. & Field, L. J., Dec 29 2014, In : PloS one. 9, 12, e115871.

Research output: Contribution to journalArticle

35 Scopus citations

The Cardiac Neural Crest and Their Role in Development and Disease

Vincentz, J. W. & Firulli, A. B., Jan 1 2014, Neural Crest Cells: Evolution, Development and Disease. Elsevier Inc., p. 205-229 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2013

A glimpse of Cre-mediated controversies in epicardial signalling

Zhang, W., Firulli, A. B. & Shou, W., Dec 1 2013, In : Cardiovascular research. 100, 3, p. 347-349 3 p.

Research output: Contribution to journalEditorial

Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity

Chen, H., Zhang, W., Sun, X., Yoshimoto, M., Chen, Z., Zhu, W., Liu, J., Shen, Y., Yong, W., Li, D., Zhang, J., Lin, Y., Li, B., VanDusen, N. J., Snider, P., Schwartz, R. J., Conway, S. J., Field, L. J., Yoder, M. C., Firulli, A. B. & 3 others, Carlesso, N., Towbin, J. A. & Shou, W., May 1 2013, In : Development (Cambridge). 140, 9, p. 1946-1957 12 p.

Research output: Contribution to journalArticle

45 Scopus citations
17 Scopus citations

Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest

Vincentz, J. W., Firulli, B. A., Lin, A., Spicer, D. B., Howard, M. J. & Firulli, A. B., Apr 15 2013, In : PLoS Genetics. 9, 3, e1003405.

Research output: Contribution to journalArticle

27 Scopus citations
2012

A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis

Vincentz, J. W., vanDusen, N. J., Fleming, A. B., Rubart, M., Firulli, B. A., Howard, M. J. & Firulli, A. B., Feb 8 2012, In : Journal of Neuroscience. 32, 6, p. 2110-2120 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Functional screening of intracardiac cell transplants using two-photon fluorescence microscopy

Tao, W., Soonpaa, M. H., Field, L. J., Chen, P. S., Firulli, A. B., Shou, W. & Rubart, M., Aug 1 2012, In : Pediatric Cardiology. 33, 6, p. 929-937 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Ontogeny of cardiac sympathetic innervation and its implications for cardiac disease

Vincentz, J. W., Rubart, M. & Firulli, A. B., Aug 1 2012, In : Pediatric Cardiology. 33, 6, p. 923-928 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Twist1 regulates Ifng expression in Th1 cells by interfering with runx3 function

Pham, D., Vincentz, J. W., Firulli, A. B. & Kaplan, M. H., Jul 15 2012, In : Journal of Immunology. 189, 2, p. 832-840 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Twist factor regulation of non-cardiomyocyte cell lineages in the developing heart

VanDusen, N. J. & Firulli, A. B., Jul 1 2012, In : Differentiation. 84, 1, p. 79-88 10 p.

Research output: Contribution to journalReview article

17 Scopus citations
2011

Hand2 loss-of-function in hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development

Barnes, R. M., Firulli, B. A., Vandusen, N. J., Morikawa, Y., Conway, S. J., Cserjesi, P., Vincentz, J. W. & Firulli, A. B., Apr 15 2011, In : Circulation research. 108, 8, p. 940-949 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Hand factors as regulators of cardiac morphogenesis and implications for congenital heart defects

Vincentz, J. W., Barnes, R. M. & Firulli, A. B., Jun 1 2011, In : Birth Defects Research Part A - Clinical and Molecular Teratology. 91, 6, p. 485-494 10 p.

Research output: Contribution to journalReview article

40 Scopus citations

Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells

Zook, E. C., Krishack, P. A., Zhang, S., Zeleznik-Le, N. J., Firulli, A. B., Witte, P. L. & Le, P. T., Nov 24 2011, In : Blood. 118, 22, p. 5723-5731 9 p.

Research output: Contribution to journalArticle

75 Scopus citations
2010

A bHLH code for cardiac morphogenesis

Conway, S. J., Firulli, B. & Firulli, A. B., Jan 1 2010, In : Pediatric Cardiology. 31, 3, p. 318-324 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability

Firulli, B. A., McConville, D. P., Byers, J. S., Vincentz, J. W., Barnes, R. M. & Firulli, A. B., Oct 1 2010, In : Developmental Dynamics. 239, 10, p. 2748-2760 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives

Barnes, R. M., Firulli, B. A., Conway, S. J., Vincentz, J. W. & Firulli, A. B., Nov 1 2010, In : Developmental Dynamics. 239, 11, p. 3086-3097 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Gene replacement strategies to test the functional redundancy of Basic helix-loop-helix transcription factor

Firulli, A. B., Firulli, B. A., Wang, J., Rogers, R. H. & Conway, S. J., Mar 8 2010, In : Pediatric Cardiology. 31, 3, p. 438-448 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development

Holler, K. L., Hendershot, T. J., Troy, S. E., Vincentz, J. W., Firulli, A. B. & Howard, M. J., May 2010, In : Developmental Biology. 341, 1, p. 291-304 14 p.

Research output: Contribution to journalArticle

41 Scopus citations

Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects

Tang, S., Snider, P., Firulli, A. B. & Conway, S. J., Aug 1 2010, In : Developmental Biology. 344, 1, p. 233-247 15 p.

Research output: Contribution to journalArticle

27 Scopus citations
2009

A twist of insight - The role of Twist-family bHLH factors in development

Barnes, R. M. & Firulli, A. B., Dec 1 2009, In : International Journal of Developmental Biology. 53, 7, p. 909-924 16 p.

Research output: Contribution to journalReview article

89 Scopus citations
2008

An absence of Twist1 results in aberrant cardiac neural crest morphogenesis

Vincentz, J. W., Barnes, R. M., Rodgers, R., Firulli, B. A., Conway, S. J. & Firulli, A. B., Aug 1 2008, In : Developmental Biology. 320, 1, p. 131-139 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons

Hendershot, T. J., Liu, H., Clouthier, D. E., Shepherd, I. T., Coppola, E., Studer, M., Firulli, A. B., Pittman, D. L. & Howard, M. J., Jul 15 2008, In : Developmental Biology. 319, 2, p. 179-191 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development

Vincentz, J. W., Barnes, R. M., Firulli, B. A., Conway, S. J. & Firulli, A. B., Dec 1 2008, In : Developmental Dynamics. 237, 12, p. 3809-3819 11 p.

Research output: Contribution to journalArticle

51 Scopus citations

Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart

Snider, P., Hinton, R. B., Moreno-Rodriguez, R. A., Wang, J., Rogers, R., Lindsley, A., Li, F., Ingram, D. A., Menick, D., Field, L., Firulli, A. B., Molkentin, J. D., Markwald, R. & Conway, S. J., Apr 1 2008, In : Circulation research. 102, 7, p. 752-760 9 p.

Research output: Contribution to journalArticle

220 Scopus citations

Phosphoregulation of twist1 provides a mechanism of cell fate control

Firulli, A. B. & Conway, S. J., Oct 1 2008, In : Current Medicinal Chemistry. 15, 25, p. 2641-2647 7 p.

Research output: Contribution to journalReview article

48 Scopus citations
2007

Cardiovascular development and the colonizing cardiac neural crest lineage

Snider, P., Olaopa, M., Firulli, A. B. & Conway, S. J., Jul 3 2007, In : TheScientificWorldJournal. 7, p. 1090-1113 24 p.

Research output: Contribution to journalReview article

91 Scopus citations

Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer

Lindsley, A., Snider, P., Zhou, H., Rogers, R., Wang, J., Olaopa, M., Kruzynska-Frejtag, A., Koushik, S. V., Lilly, B., Burch, J. B. E., Firulli, A. B. & Conway, S. J., Jul 15 2007, In : Developmental Biology. 307, 2, p. 340-355 16 p.

Research output: Contribution to journalArticle

68 Scopus citations

Mutations within helix I of twist1 result in distinct limb defects and variation of DNA binding affinities

Firulli, B. A., Redick, B. A., Conway, S. J. & Firulli, A. B., Sep 14 2007, In : Journal of Biological Chemistry. 282, 37, p. 27536-27546 11 p.

Research output: Contribution to journalArticle

60 Scopus citations
2005

Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities

Firulli, B. A., Krawchuk, D., Centonze, V. E., Vargesson, N., Virshup, D. M., Conway, S. J., Cserjesi, P., Laufer, E. & Firulli, A. B., Apr 1 2005, In : Nature genetics. 37, 4, p. 373-381 9 p.

Research output: Contribution to journalArticle

127 Scopus citations
2004
9 Scopus citations

Fluorescence resonance energy transfer (FRET) as a method to calculate the dimerization strength of basic Helix-loop-Helix (bHLH) proteins

Centonze, V. E., Firulli, B. A. & Firulli, A. B., May 12 2004, In : Biological Procedures Online. 6, 1, p. 78-82 5 p.

Research output: Contribution to journalArticle

12 Scopus citations