Bernardino Ghetti

  • 31980 Citations
  • 87 h-Index
1967 …2021

Research output per year

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Publications

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Article
1997

Decreased IGF-I gene expression during the apoptosis of Purkinje cells in pcd mice

Zhang, W., Ghetti, B. & Lee, W. H., Feb 20 1997, In : Developmental Brain Research. 98, 2, p. 164-176 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Diverse cell death pathways result from a single missense mutation in weaver mouse

Migheli, A., Piva, R., Wei, J., Attanasio, A., Casolino, S., Hodes, M. E., Dlouhy, S. R., Bayer, S. A. & Ghetti, B., Dec 1 1997, In : American Journal of Pathology. 151, 6, p. 1629-1638 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments

Spillantini, M. G., Goedert, M., Crowther, R. A., Murrell, J. R., Farlow, M. R. & Ghetti, B., Apr 15 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 8, p. 4113-4118 6 p.

Research output: Contribution to journalArticle

269 Scopus citations

Familial multiple-system tauopathy with presenile dementia is localized to chromosome 17

Murrell, J. R., Koller, D., Foroud, T., Goedert, M., Spillantini, M. G., Edenberg, H. J., Farlow, M. R. & Ghetti, B., Nov 1997, In : American Journal of Human Genetics. 61, 5, p. 1131-1138 8 p.

Research output: Contribution to journalArticle

64 Scopus citations

Gerstmann-Straussler-Scheinker disease with the PRNP P102L mutation and valine at codon 129

Young, K., Clark, H. B., Piccardo, P., Dlouhy, S. R. & Ghetti, B., Feb 1 1997, In : Molecular Brain Research. 44, 1, p. 147-150 4 p.

Research output: Contribution to journalArticle

47 Scopus citations

In vitro evidence that the reduction in mesencepalic dopaminergic neurons in the weaver heterozygote is not due to a failure in target cell interaction

Won, L., Ghetti, B., Heller, B. & Heller, A., Jul 2 1997, In : Experimental Brain Research. 115, 1, p. 174-179 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
15 Scopus citations

Subacute sclerosing panencephalitis manifesting as viral retinitis: Clinical and histopathologic findings

Park, D. W., Boldt, H. C., Massicotte, S. J., Akang, E. E. U., Roos, K. L., Bodnar, A., Pless, J., Ghetti, B. & Pascuzzi, R. M., Jan 1 1997, In : American Journal of Ophthalmology. 123, 4, p. 533-542 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
1998

Altered responses to potassium in cerebellar neurons from weaver heterozygote mice

Fox, A. P., Dlouhy, S., Ghetti, B., Hurley, J. H., Nucifora, P. G. P., Nelson, D. J., Won, L. & Heller, A., Nov 30 1998, In : Experimental Brain Research. 123, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

An antibody raised against a conserved sequence of the prion protein recognizes pathological isoforms in human and animal prion diseases, including Creutzfeldt-Jakob disease and bovine spongiform encephalopathy

Piccardo, P., Langeveld, J. P. M., Hill, A. F., Dlouhy, S. R., Young, K., Giaccone, G., Rossi, G., Bugiani, M., Bugiani, O., Meloen, R. H., Collinge, J., Tagliavini, F. & Ghetti, B., Jun 1 1998, In : American Journal of Pathology. 152, 6, p. 1415-1420 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Characterization of murine Girk2 transcript isoforms: Structure and differential expression

Wei, J., Hodes, M. E., Piva, R., Feng, Y., Wang, Y., Ghetti, B. & Dlouhy, S. R., Aug 1 1998, In : Genomics. 51, 3, p. 379-390 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Creutzfeldt-Jakob disease in a husband and wife

Brown, P., Cervenáková, L., McShane, L., Goldfarb, L. G., Bishop, K., Bastian, F., Kirkpatrick, J., Piccardo, P., Ghetti, B. & Gajdusek, D. C., Mar 1998, In : Neurology. 50, 3, p. 684-688 5 p.

Research output: Contribution to journalArticle

31 Scopus citations

Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues

Jiménez-Huete, A., Lievens, P. M. J., Vidal, R., Piccardo, P., Ghetti, B., Tagliavini, F., Frangione, B. & Prelli, F., Nov 1998, In : American Journal of Pathology. 153, 5, p. 1561-1572 12 p.

Research output: Contribution to journalArticle

146 Scopus citations

FDG-PET and MRI in temporal lobe epilepsy: Relationship to febrile seizures, hippocampal sclerosis and outcome

Salanova, V., Markand, O., Worth, R., Smith, R., Wellman, H., Hutchins, G., Park, H., Ghetti, B. & Azzarelli, B., Jun 15 1998, In : Acta Neurologica Scandinavica. 97, 3, p. 146-153 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Frontotemporal dementia and Parkinsonism linked to chromosome 17: A new group of tauopathies

Spillantini, M. G., Bird, T. D. & Ghetti, B., Jan 1 1998, In : Brain Pathology. 8, 2, p. 387-402 16 p.

Research output: Contribution to journalArticle

354 Scopus citations

Hypothalamic-pituitary-gonadal axis in the mutant weaver mouse

Schwartz, N. B., Szabo, M., Verina, T., Wei, J., Dlouhy, S. R., Won, L., Heller, A., Hodes, M. E. & Ghetti, B., Dec 1 1998, In : Neuroendocrinology. 68, 6, p. 374-385 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Lewy bodies contain altered α-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes

Lippa, C. F., Fujiwara, H., Mann, D. M. A., Giasson, B., Baba, M., Schmidt, M. L., Nee, L. E., O'Connell, B., Pollen, D. A., St. George-Hyslop, P., Ghetti, B., Nochlin, D., Bird, T. D., Cairns, N. J., Lee, V. M. Y., Iwatsubo, T. & Trojanowski, J. Q., Nov 1998, In : American Journal of Pathology. 153, 5, p. 1365-1370 6 p.

Research output: Contribution to journalArticle

394 Scopus citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

Spillantini, M. G., Murrell, J. R., Goedert, M., Farlow, M. R., Klug, A. & Ghetti, B., Jun 23 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 13, p. 7737-7741 5 p.

Research output: Contribution to journalArticle

1206 Scopus citations

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation

Chiesa, R., Piccardo, P., Ghetti, B. & Harris, D. A., Dec 1998, In : Neuron. 21, 6, p. 1339-1351 13 p.

Research output: Contribution to journalArticle

261 Scopus citations

Phenotypic variability of Gerstmann-Straussler-Scheinker disease is associated with prion protein heterogeneity

Piccardo, P., Dlouhy, S. R., Lievens, P. M. J., Young, K., Bird, T. D., Nochlin, D., Dickson, D. W., Vinters, H. V., Zimmerman, T. R., Mackenzie, I. R. A., Kish, S. J., Ang, L. C., De Carli, C., Pocchiari, M., Brown, P., Gibbs, C. J., Gajdusek, D. C., Bugiani, O., Ironside, J., Tagliavini, F. & 1 others, Ghetti, B., Oct 1998, In : Journal of Neuropathology and Experimental Neurology. 57, 10, p. 979-988 10 p.

Research output: Contribution to journalArticle

Open Access
168 Scopus citations
1999

A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum

Migheli, A., Piva, R., Casolino, S., Atzori, C., Dlouhy, S. R. & Ghetti, B., Aug 1999, In : American Journal of Pathology. 155, 2, p. 365-373 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Alteration of IGF system gene expression during the postnatal development of pcd mice

Zhang, W., Ghetti, B., Yang, X. L. & Lee, W. H., Jan 1 1999, In : Journal of Endocrinology. 163, 2, p. 191-198 8 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy

Delisle, M. B., Murrell, J. R., Richardson, R., Trofatter, J. A., Rascol, O., Soulages, X., Mohr, M., Calvas, P. & Ghetti, B., Jul 1 1999, In : Acta Neuropathologica. 98, 1, p. 62-77 16 p.

Research output: Contribution to journalArticle

140 Scopus citations

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

Bales, K. R., Verina, T., Cummins, D. J., Du, Y., Dodel, R. C., Saura, J., Fishman, C. E., Delong, C. A., Piccardo, P., Petegnief, V., Ghetti, B. & Paul, S. M., Dec 21 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 26, p. 15233-15238 6 p.

Research output: Contribution to journalArticle

386 Scopus citations

Chapter 5 Human Prion Diseases

Ghetti, B. & Gambetti, P., Dec 1 1999, In : Advances in Cell Aging and Gerontology. 3, C, p. 135-187 53 p.

Research output: Contribution to journalArticle

6 Scopus citations

Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects

Parchi, P., Giese, A., Capellari, S., Brown, P., Schulz-Schaeffer, W., Windl, O., Zerr, I., Budka, H., Kopp, N., Piccardo, P., Poser, S., Rojiani, A., Streichemberger, N., Julien, J., Vital, C., Ghetti, B., Gambetti, P. & Kretzschmar, H., Aug 23 1999, In : Annals of Neurology. 46, 2, p. 224-233 10 p.

Research output: Contribution to journalArticle

1031 Scopus citations

Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau

Bugiani, O., Murrell, J. R., Giaccone, G., Hasegawa, M., Ghigo, G., Tabaton, M., Morbin, M., Primavera, A., Carella, F., Solaro, C., Grisoli, M., Savoiardo, M., Spillantini, M. G., Tagliavini, F., Goedert, M. & Ghetti, B., Jun 1999, In : Journal of Neuropathology and Experimental Neurology. 58, 6, p. 667-677 11 p.

Research output: Contribution to journalArticle

Open Access
302 Scopus citations

Glial cell line-derived neurotrophic factor protects midbrain dopamine neurons from the lethal action of the weaver gene: A quantitative immunocytochemical study

Broome, J. D., Wills, K. V., Lapchak, P. A., Ghetti, B., Camp, L. L. & Bayer, S. A., Aug 5 1999, In : Developmental Brain Research. 116, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17

Varani, L., Hasegawa, M., Spillantini, M. G., Smith, M. J., Murrell, J. R., Ghetti, B., Klug, A., Goedert, M. & Varani, G., Jul 6 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 14, p. 8229-8234 6 p.

Research output: Contribution to journalArticle

187 Scopus citations

Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits

Murrell, J. R., Spillantini, M. G., Zolo, P., Guazzelli, M., Smith, M. J., Hasegawa, M., Redi, F., Crowther, R. A., Pietrini, P., Ghetti, B. & Goedert, M., Dec 1999, In : Journal of Neuropathology and Experimental Neurology. 58, 12, p. 1207-1226 20 p.

Research output: Contribution to journalArticle

Open Access
187 Scopus citations

Tau pathology in a family with dementia and a P301L mutation in tau

Mirra, S. S., Murrell, J. R., Gearing, M., Spillantini, M. G., Goedert, M., Crowther, R. A., Levey, A. I., Jones, R., Green, J., Shoffner, J. M., Wainer, B. H., Schmidt, M. L., Trojanowski, J. Q. & Ghetti, B., Apr 1999, In : Journal of Neuropathology and Experimental Neurology. 58, 4, p. 335-345 11 p.

Research output: Contribution to journalArticle

Open Access
151 Scopus citations
2000

Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation

Chiesa, R., Drisaldi, B., Quaglio, E., Migheli, A., Piccardo, P., Ghetti, B. & Harris, D. A., May 9 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 10, p. 5574-5579 6 p.

Research output: Contribution to journalArticle

126 Scopus citations

Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene

Murrell, J. R., Hake, A. M., Quaid, K. A., Farlow, M. R. & Ghetti, B., Jun 2000, In : Archives of Neurology. 57, 6, p. 885-887 3 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

Evidence of elevated intracellular calcium levels in weaver homozygote mice

Harkins, A. B., Dlouhy, S., Ghetti, B., Cahill, A. L., Won, L., Heller, B., Heller, A. & Fox, A. P., Apr 15 2000, In : Journal of Physiology. 524, 2, p. 447-455 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Familial Alzheimer's disease: Site of mutation influences clinical phenotype

Lippa, C. F., Swearer, J. M., Kane, K. J., Nochlin, D., Bird, T. D., Ghetti, B., Nee, L. E., St. George-Hyslop, P., Pollen, D. A. & Drachman, D. A., Sep 18 2000, In : Annals of Neurology. 48, 3, p. 376-379 4 p.

Research output: Contribution to journalArticle

48 Scopus citations

Genetic influence on the structural variations of the abnormal prion protein

Parchi, P., Zou, W., Wang, W., Brown, P., Capellari, S., Ghetti, B., Kopp, N., Schulz-Schaeffer, W. J., Kretzschmar, H. A., Head, M. W., Ironside, J. W., Gambetti, P. & Chen, S. G., Aug 29 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 18, p. 10168-10172 5 p.

Research output: Contribution to journalArticle

Open Access
244 Scopus citations

Guidelines for the diagnosis of dementia and Alzheimer's disease

Sorbi, S., Alberoni, M., Alfieri, P., Amici, S., Antana, D., Appollonio, I., Avanzi, S., Bartoli, A., Bergamasco, B., Bracco, L., Bruni, A., Bugiani, O., Caffarra, P., Caltagirone, C., Carolei, A., Rosa, A., Ciannella, L., Citterio, A., Daniele, A., D'Achille, G. & 59 others, Del Curatolo, G., Dell'Agnello, G., Durante, D., Farina, E., Ferrero, P., Forleo, P., Gainotti, G., Gabriele, P., Galante, E., Gallai, V., Gallassi, R., Gasparini, M., Ghetti, B., Giaccone, G., Girotti, F., Grimaldi, L., Grioli, S., Guarnieri, B. M., Grottoli, S., Iemolo, F., Latorraca, S., Le Pira, F., Lenzi, G. L., Lorusso, S., Mariani, C., Marcon, G., Mascia, V., Mearelli, S., Morante, M., Morbin, M., Musicco, M., Nardelli, E., Nichelli, P., Padovani, A., Paganini, M., Pantieri, R., Parisen, P., Parnetti, L., Passerella, B., Pettenati, C., Piacentini, S., Piccoli, F., Piccolini, C., Pizzolato, G., Provinciali, L., Pugliese, N., Redi, F., Ruggieri, R. M., Ruggiero, U., Saetta, M., Schoenuber, R., Silveri, M. C., Sorrentino, G., Sucapane, P., Stracciari, A., Tabaton, M., Tagliavini, F., Toso, V. & Valluzzi, F., Aug 1 2000, In : Neurological Sciences. 21, 4, p. 187-194 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Maladie neuro-dégénérative associée à une mutation du codon 279 (N279K) de l'exon 10 du gène de la protéine Tau

Translated title of the contribution: Neurodegenerative disease with a mutation at codon 279 (N279 K) in exon 10 of the protein Tau geneDelisle, M. B., Uro-Coste, E., Murrell, J. R., Rascol, O. & Ghetti, B., Dec 1 2000, In : Bulletin de l'Academie Nationale de Medecine. 184, 4, p. 799-809 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Neuropathology of Gerstmann-Straussler-Scheinker disease

Bugiani, O., Giaccone, G., Piccardo, P., Morbin, M., Tagliavini, F. & Ghetti, B., Jul 1 2000, In : Microscopy Research and Technique. 50, 1, p. 10-15 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Neuroserpin mutation S52R causes Neuroserpin accumulation in neurons and is associated with progressive myoclonus epilepsy

Takao, M., Benson, M. D., Murrell, J. R., Yazaki, M., Piccardo, P., Unverzagt, F. W., Davis, R. L., Holohan, P. D., Lawrence, D. A., Richardson, R., Farlow, M. R. & Ghetti, B., Jan 1 2000, In : Journal of Neuropathology and Experimental Neurology. 59, 12, p. 1070-1086 17 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

Presenilin-1 mutations in Alzheimer's disease

Russo, C., Schettini, G., Saido, T. C., Hulette, C., Lippa, C., Lannfelt, L., Ghetti, B., Gambetti, P., Tabaton, M. & Teller, J. K., Jun 1 2000, In : Nature. 405, 6786, p. 531-532 2 p.

Research output: Contribution to journalArticle

123 Scopus citations

Progress in hereditary tauopathies: A mutation in the Tau gene (G389R) causes a pick disease-like syndrome

Ghetti, B., Murrell, J. R., Zolo, P., Spillantini, M. G. & Goedert, M., Jan 1 2000, In : Annals of the New York Academy of Sciences. 920, p. 52-62 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Senile dementia associated with amyloid β protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-ε4 allele

Vidal, R., Calero, M., Piccardo, P., Farlow, M. R., Unverzagt, F. W., Méndez, E., Jiménez-Huete, A., Beavis, R., Gallo, G., Gomez-Tortosa, E., Ghiso, J., Hyman, B. T., Frangione, B. & Ghetti, B., Jul 1 2000, In : Acta Neuropathologica. 100, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

56 Scopus citations
44 Scopus citations

The weaver gene continues to target late-generated dopaminergic neurons in midbrain areas at P90

Martí, J., Wills, K. V., Ghetti, B. & Bayer, S. A., Aug 30 2000, In : Developmental Brain Research. 122, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

The weaver gene has no effect on the generation patterns of mesencephalic dopaminergic neurons

Martí, J., Wills, K. V., Ghetti, B. & Bayer, S. A., Aug 30 2000, In : Developmental Brain Research. 122, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2001

A 7-kDa Prion Protein (PrP) Fragment, an Integral Component of the PrP Region Required for Infectivity, Is the Major Amyloid Protein in Gerstmann-Sträussler-Scheinker Disease A117V

Tagliavini, F., Lievens, P. M. J., Tranchant, C., Warter, J. M., Mohr, M., Giaccone, G., Perini, F., Rossi, G., Salmona, M., Piccardo, P., Ghetti, B., Beavis, R. C., Bugiani, O., Frangione, B. & Prelli, F., Feb 23 2001, In : Journal of Biological Chemistry. 276, 8, p. 6009-6015 7 p.

Research output: Contribution to journalArticle

107 Scopus citations

Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis

Atzori, C., Ghetti, B., Piva, R., Srinivasan, A. N., Zolo, P., Delisle, M. B., Mirra, S. S. & Migheli, A., Jan 1 2001, In : Journal of Neuropathology and Experimental Neurology. 60, 12, p. 1190-1197 8 p.

Research output: Contribution to journalArticle

Open Access
137 Scopus citations

A new PRNP mutation (G131V) associated with Gerstmann-Sträussler-Scheinker disease

Panegyres, P. K., Toufexis, K., Kakulas, B. A., Cernevakova, L., Brown, P., Ghetti, B., Piccardo, P. & Dlouhy, S. R., Jan 1 2001, In : Archives of Neurology. 58, 11, p. 1899-1902 4 p.

Research output: Contribution to journalArticle

Open Access
56 Scopus citations

A transgenic model of a familial prion disease

Harris, D. A., Chiesa, R., Drisaldi, B., Quaglio, E., Migheli, A., Piccardo, P. & Ghetti, B., Jan 1 2001, In : Archives of Virology, Supplement. 16, p. 103-112 10 p.

Research output: Contribution to journalArticle

5 Scopus citations