Bernardino Ghetti

  • 31656 Citations
  • 87 h-Index
1967 …2021

Research output per year

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Publications

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2003

Hereditary ferritinopathy

Vidal, R., Delisle, M. B., Rascol, O. & Ghetti, B., Mar 15 2003, In : Journal of the Neurological Sciences. 207, 1-2, p. 110-111 2 p.

Research output: Contribution to journalArticle

32 Scopus citations

Molecular distinction between pathogenic and infectious properties of the prion protein

Chiesa, R., Piccardo, P., Quaglio, E., Drisaldi, B., Si-Hoe, S. L., Takao, M., Ghetti, B. & Harris, D. A., Jul 1 2003, In : Journal of virology. 77, 13, p. 7611-7622 12 p.

Research output: Contribution to journalArticle

115 Scopus citations

Ubiquitination of α-Synuclein in Lewy Bodies Is a Pathological Event Not Associated with Impairment of Proteasome Function

Tofaris, G. K., Razzaq, A., Ghetti, B., Lilley, K. S. & Spillantini, M. G., Nov 7 2003, In : Journal of Biological Chemistry. 278, 45, p. 44405-44411 7 p.

Research output: Contribution to journalArticle

251 Scopus citations

Variable phenotype in a P102L Gerstmann-Sträussler-Scheinker Italian family

De Michele, G., Pocchiari, M., Petraroli, R., Manfredi, M., Caneve, G., Coppola, G., Casali, C., Saccà, F., Piccardo, P., Salvatore, E., Berardelli, A., Orio, M., Barbieri, F., Ghetti, B. & Filla, A., Aug 1 2003, In : Canadian Journal of Neurological Sciences. 30, 3, p. 233-236 4 p.

Research output: Contribution to journalArticle

19 Scopus citations
2002

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301s tau protein

Allen, B., Ingram, E., Takao, M., Smith, M. J., Jakes, R., Virdee, K., Yoshida, H., Holzer, M., Craxton, M., Emson, P. C., Atzori, C., Migheli, A., Anthony Crowther, R., Ghetti, B., Spillantini, M. G. & Goedert, M., Nov 1 2002, In : Journal of Neuroscience. 22, 21, p. 9340-9351 12 p.

Research output: Contribution to journalArticle

420 Scopus citations

A combined immunohistochemical and autoradiographic method to detect midbrain dopaminergic neurons and determine their time of origin

Martí, J., Wills, K. V., Ghetti, B. & Bayer, S. A., Jul 22 2002, In : Brain Research Protocols. 9, 3, p. 197-205 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

A novel mutation (G217D) in the Presenilin 1 gene (PSEN1) in a Japanese family: Presenile dementia and parkinsonism are associated with cotton wool plaques in the cortex and striatum

Takao, M., Ghetti, B., Hayakawa, I., Ikeda, E., Fukuuchi, Y., Miravalle, L., Piccardo, P., Murell, J. R., Glazier, B. S. & Koto, A., Dec 1 2002, In : Acta Neuropathologica. 104, 2, p. 155-170 16 p.

Research output: Contribution to journalArticle

55 Scopus citations

Association between conformational mutations in neuroserpin and onset and severity of dementia

Davis, R. L., Shrimpton, A. E., Carrell, R. W., Lomas, D. A., Gerhard, L., Baumann, B., Lawrence, D. A., Yepes, M., Kim, T. S., Ghetti, B., Piccardo, P., Takao, M., Lacbawan, F., Muenke, M., Sifers, R. N., Bradshaw, C. B., Kent, P. F., Collins, G. H., Larocca, D. & Holohan, P. D., Jun 29 2002, In : Lancet. 359, 9325, p. 2242-2247 6 p.

Research output: Contribution to journalArticle

118 Scopus citations

Clinical and genetic studies of families with the tau N279K mutation (FTDP-17)

Tsuboi, Y., Baker, M., Hutton, M. L., Uitti, R. J., Rascol, O., Delisle, M. B., Soulages, X., Murrell, J. R., Ghetti, B., Yasuda, M., Komure, O., Kuno, S., Arima, K., Sunohara, N., Kobayashi, T., Mizuno, Y. & Wszolek, Z. K., Dec 10 2002, In : Neurology. 59, 11, p. 1791-1793 3 p.

Research output: Contribution to journalArticle

35 Scopus citations

Clinical features and disease haplotypes of individuals with the N279K tau gene mutation: A comparison of the pallidopontonigral degeneration kindred and a French family

Tsuboi, Y., Uitti, R. J., Delisle, M. B., Ferreira, J. J., Brefel-Courbon, C., Rascol, O., Ghetti, B., Murrell, J. R., Hutton, M., Baker, M. & Wszolek, Z. K., Jan 1 2002, In : Archives of Neurology. 59, 6, p. 943-950 8 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Dementia with Lewy bodies in a Nigerian: A case report

Ogunniyi, A., Akang, E. E. U., Gureje, O., Takao, M., Piccardo, P., Baiyewu, O., Hall, K. S., Ghetti, B. & Hendrie, H. C., Jun 1 2002, In : International Psychogeriatrics. 14, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
22 Scopus citations

Insomnia associated with thalamic involvement in E200K Creutzfeldt-Jakob disease

Taratuto, A. L., Piccardo, P., Reich, E. G., Chen, S. G., Sevlever, G., Schultz, M., Luzzi, A. A., Rugiero, M., Abecasis, G., Endelman, M., Garcia, A. M., Capellari, S., Xie, Z., Lugaresi, E., Gambetti, P., Dlouhy, S. R. & Ghetti, B., Feb 12 2002, In : Neurology. 58, 3, p. 362-367 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

P301L tauopathyconfocal immunofluorescence study of perinuclear aggregation of the mutated protein

Adamec, E., Murrell, J. R., Takao, M., Hobbs, W., Nixon, R. A., Ghetti, B. & Vonsattel, J. P., Aug 15 2002, In : Journal of the Neurological Sciences. 200, 1-2, p. 85-93 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ42 production

Moehlmann, T., Winkler, E., Xia, X., Edbauer, D., Murrell, J., Capell, A., Kaether, C., Zheng, H., Ghetti, B., Haass, C. & Steiner, H., Jun 11 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 12, p. 8025-8030 6 p.

Research output: Contribution to journalArticle

218 Scopus citations

Regional differences in the Purkinje cells settled pattern: A comparative autoradiographic study in control and homozygous weaver mice

Marti, J., Wills, K. V., Ghetti, B. & Bayer, S. A., Jan 1 2002, In : Experimental Neurology. 175, 1, p. 168-181 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
2001

A 7-kDa Prion Protein (PrP) Fragment, an Integral Component of the PrP Region Required for Infectivity, Is the Major Amyloid Protein in Gerstmann-Sträussler-Scheinker Disease A117V

Tagliavini, F., Lievens, P. M. J., Tranchant, C., Warter, J. M., Mohr, M., Giaccone, G., Perini, F., Rossi, G., Salmona, M., Piccardo, P., Ghetti, B., Beavis, R. C., Bugiani, O., Frangione, B. & Prelli, F., Feb 23 2001, In : Journal of Biological Chemistry. 276, 8, p. 6009-6015 7 p.

Research output: Contribution to journalArticle

107 Scopus citations

Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis

Atzori, C., Ghetti, B., Piva, R., Srinivasan, A. N., Zolo, P., Delisle, M. B., Mirra, S. S. & Migheli, A., Jan 1 2001, In : Journal of Neuropathology and Experimental Neurology. 60, 12, p. 1190-1197 8 p.

Research output: Contribution to journalArticle

Open Access
137 Scopus citations

A new PRNP mutation (G131V) associated with Gerstmann-Sträussler-Scheinker disease

Panegyres, P. K., Toufexis, K., Kakulas, B. A., Cernevakova, L., Brown, P., Ghetti, B., Piccardo, P. & Dlouhy, S. R., Jan 1 2001, In : Archives of Neurology. 58, 11, p. 1899-1902 4 p.

Research output: Contribution to journalArticle

Open Access
56 Scopus citations

A transgenic model of a familial prion disease

Harris, D. A., Chiesa, R., Drisaldi, B., Quaglio, E., Migheli, A., Piccardo, P. & Ghetti, B., Jan 1 2001, In : Archives of Virology, Supplement. 16, p. 103-112 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Biochemical characterization of a neuroserpin variant associated with hereditary dementia

Yazaki, M., Liepnieks, J. J., Murrell, J. R., Takao, M., Guenther, B., Piccardo, P., Farlow, M. R., Ghetti, B. & Benson, M. D., Jan 1 2001, In : American Journal of Pathology. 158, 1, p. 227-233 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Codeposition of cystatin C with amyloid-β protein in the brain of alzheimer disease patients

Levy, E., Sastre, M., Kumar, A., Gallo, G., Piccardo, P., Ghetti, B. & Tagliavini, F., Jan 1 2001, In : Journal of Neuropathology and Experimental Neurology. 60, 1, p. 94-104 11 p.

Research output: Contribution to journalArticle

Open Access
135 Scopus citations

Ectopic white matter neurons, a developmental abnormality that may be caused by the PSEN1 S169L mutation in a case of familial AD with myoclonus and seizures

Takao, M., Ghetti, B., Murrell, J. R., Unverzagt, F. W., Giaccone, G., Tagliavini, F., Bugiani, O., Piccardo, P., Hulette, C. M., Crain, B. J., Farlow, M. R. & Heyman, A., Jan 1 2001, In : Journal of Neuropathology and Experimental Neurology. 60, 12, p. 1137-1152 16 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders

Cataldo, A., William Rebeck, G., Ghetti, B., Hulette, C., Lippa, C., Van Broeckhoven, C., Van Duijn, C., Cras, P., Bogdanovic, N., Bird, T., Peterhoff, C. & Nixon, R., Nov 12 2001, In : Annals of Neurology. 50, 5, p. 661-665 5 p.

Research output: Contribution to journalArticle

63 Scopus citations

Evidence that the loss of Purkinje cells and deep cerebellar nuclei neurons in homozygous weaver is not related to neurogenetic patterns

Martí, J., Wills, K. V., Ghetti, B. & Bayer, S. A., Oct 9 2001, In : International Journal of Developmental Neuroscience. 19, 6, p. 599-610 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Primary myopathy and accumulation of PRPSc-like molecules in peripheral tissues of transgenic mice expressing a prion protein insertional mutation

Chiesa, R., Pestronk, A., Schmidt, R. E., Tourtellotte, W. G., Ghetti, B., Piccardo, P. & Harris, R. E., Jan 1 2001, In : Neurobiology of Disease. 8, 2, p. 279-288 10 p., 90400.

Research output: Contribution to journalArticle

35 Scopus citations

Prion proteins with different conformations accumulate in Gerstmann-Sträussler-Scheinker disease caused by A117V and F198S mutations

Piccardo, P., Liepnieks, J. J., William, A., Dlouhy, S. R., Farlow, M. R., Young, K., Nochlin, D., Bird, T. D., Nixon, R. R., Ball, M. J., DeCarli, C., Bugiani, O., Tagliavini, F., Benson, M. D. & Ghetti, B., Jan 1 2001, In : American Journal of Pathology. 158, 6, p. 2201-2207 7 p.

Research output: Contribution to journalArticle

63 Scopus citations
2000

Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation

Chiesa, R., Drisaldi, B., Quaglio, E., Migheli, A., Piccardo, P., Ghetti, B. & Harris, D. A., May 9 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 10, p. 5574-5579 6 p.

Research output: Contribution to journalArticle

126 Scopus citations

Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene

Murrell, J. R., Hake, A. M., Quaid, K. A., Farlow, M. R. & Ghetti, B., Jun 2000, In : Archives of Neurology. 57, 6, p. 885-887 3 p.

Research output: Contribution to journalArticle

Open Access
67 Scopus citations

Evidence of elevated intracellular calcium levels in weaver homozygote mice

Harkins, A. B., Dlouhy, S., Ghetti, B., Cahill, A. L., Won, L., Heller, B., Heller, A. & Fox, A. P., Apr 15 2000, In : Journal of Physiology. 524, 2, p. 447-455 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Familial Alzheimer's disease: Site of mutation influences clinical phenotype

Lippa, C. F., Swearer, J. M., Kane, K. J., Nochlin, D., Bird, T. D., Ghetti, B., Nee, L. E., St. George-Hyslop, P., Pollen, D. A. & Drachman, D. A., Sep 18 2000, In : Annals of Neurology. 48, 3, p. 376-379 4 p.

Research output: Contribution to journalArticle

48 Scopus citations

Genetic influence on the structural variations of the abnormal prion protein

Parchi, P., Zou, W., Wang, W., Brown, P., Capellari, S., Ghetti, B., Kopp, N., Schulz-Schaeffer, W. J., Kretzschmar, H. A., Head, M. W., Ironside, J. W., Gambetti, P. & Chen, S. G., Aug 29 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 18, p. 10168-10172 5 p.

Research output: Contribution to journalArticle

Open Access
244 Scopus citations

Guidelines for the diagnosis of dementia and Alzheimer's disease

Sorbi, S., Alberoni, M., Alfieri, P., Amici, S., Antana, D., Appollonio, I., Avanzi, S., Bartoli, A., Bergamasco, B., Bracco, L., Bruni, A., Bugiani, O., Caffarra, P., Caltagirone, C., Carolei, A., Rosa, A., Ciannella, L., Citterio, A., Daniele, A., D'Achille, G. & 59 others, Del Curatolo, G., Dell'Agnello, G., Durante, D., Farina, E., Ferrero, P., Forleo, P., Gainotti, G., Gabriele, P., Galante, E., Gallai, V., Gallassi, R., Gasparini, M., Ghetti, B., Giaccone, G., Girotti, F., Grimaldi, L., Grioli, S., Guarnieri, B. M., Grottoli, S., Iemolo, F., Latorraca, S., Le Pira, F., Lenzi, G. L., Lorusso, S., Mariani, C., Marcon, G., Mascia, V., Mearelli, S., Morante, M., Morbin, M., Musicco, M., Nardelli, E., Nichelli, P., Padovani, A., Paganini, M., Pantieri, R., Parisen, P., Parnetti, L., Passerella, B., Pettenati, C., Piacentini, S., Piccoli, F., Piccolini, C., Pizzolato, G., Provinciali, L., Pugliese, N., Redi, F., Ruggieri, R. M., Ruggiero, U., Saetta, M., Schoenuber, R., Silveri, M. C., Sorrentino, G., Sucapane, P., Stracciari, A., Tabaton, M., Tagliavini, F., Toso, V. & Valluzzi, F., Aug 1 2000, In : Neurological Sciences. 21, 4, p. 187-194 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Maladie neuro-dégénérative associée à une mutation du codon 279 (N279K) de l'exon 10 du gène de la protéine Tau

Translated title of the contribution: Neurodegenerative disease with a mutation at codon 279 (N279 K) in exon 10 of the protein Tau geneDelisle, M. B., Uro-Coste, E., Murrell, J. R., Rascol, O. & Ghetti, B., Dec 1 2000, In : Bulletin de l'Academie Nationale de Medecine. 184, 4, p. 799-809 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Neuropathology of Gerstmann-Straussler-Scheinker disease

Bugiani, O., Giaccone, G., Piccardo, P., Morbin, M., Tagliavini, F. & Ghetti, B., Jul 1 2000, In : Microscopy Research and Technique. 50, 1, p. 10-15 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Neuroserpin mutation S52R causes Neuroserpin accumulation in neurons and is associated with progressive myoclonus epilepsy

Takao, M., Benson, M. D., Murrell, J. R., Yazaki, M., Piccardo, P., Unverzagt, F. W., Davis, R. L., Holohan, P. D., Lawrence, D. A., Richardson, R., Farlow, M. R. & Ghetti, B., Jan 1 2000, In : Journal of Neuropathology and Experimental Neurology. 59, 12, p. 1070-1086 17 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

Presenilin-1 mutations in Alzheimer's disease

Russo, C., Schettini, G., Saido, T. C., Hulette, C., Lippa, C., Lannfelt, L., Ghetti, B., Gambetti, P., Tabaton, M. & Teller, J. K., Jun 1 2000, In : Nature. 405, 6786, p. 531-532 2 p.

Research output: Contribution to journalArticle

123 Scopus citations

Progress in hereditary tauopathies: A mutation in the Tau gene (G389R) causes a pick disease-like syndrome

Ghetti, B., Murrell, J. R., Zolo, P., Spillantini, M. G. & Goedert, M., Jan 1 2000, In : Annals of the New York Academy of Sciences. 920, p. 52-62 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Senile dementia associated with amyloid β protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-ε4 allele

Vidal, R., Calero, M., Piccardo, P., Farlow, M. R., Unverzagt, F. W., Méndez, E., Jiménez-Huete, A., Beavis, R., Gallo, G., Gomez-Tortosa, E., Ghiso, J., Hyman, B. T., Frangione, B. & Ghetti, B., Jul 1 2000, In : Acta Neuropathologica. 100, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

56 Scopus citations
44 Scopus citations

The weaver gene continues to target late-generated dopaminergic neurons in midbrain areas at P90

Martí, J., Wills, K. V., Ghetti, B. & Bayer, S. A., Aug 30 2000, In : Developmental Brain Research. 122, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

The weaver gene has no effect on the generation patterns of mesencephalic dopaminergic neurons

Martí, J., Wills, K. V., Ghetti, B. & Bayer, S. A., Aug 30 2000, In : Developmental Brain Research. 122, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
1999

A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum

Migheli, A., Piva, R., Casolino, S., Atzori, C., Dlouhy, S. R. & Ghetti, B., Aug 1999, In : American Journal of Pathology. 155, 2, p. 365-373 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Alteration of IGF system gene expression during the postnatal development of pcd mice

Zhang, W., Ghetti, B., Yang, X. L. & Lee, W. H., Jan 1 1999, In : Journal of Endocrinology. 163, 2, p. 191-198 8 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy

Delisle, M. B., Murrell, J. R., Richardson, R., Trofatter, J. A., Rascol, O., Soulages, X., Mohr, M., Calvas, P. & Ghetti, B., Jul 1 1999, In : Acta Neuropathologica. 98, 1, p. 62-77 16 p.

Research output: Contribution to journalArticle

140 Scopus citations

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

Bales, K. R., Verina, T., Cummins, D. J., Du, Y., Dodel, R. C., Saura, J., Fishman, C. E., Delong, C. A., Piccardo, P., Petegnief, V., Ghetti, B. & Paul, S. M., Dec 21 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 26, p. 15233-15238 6 p.

Research output: Contribution to journalArticle

383 Scopus citations

Chapter 5 Human Prion Diseases

Ghetti, B. & Gambetti, P., Dec 1 1999, In : Advances in Cell Aging and Gerontology. 3, C, p. 135-187 53 p.

Research output: Contribution to journalArticle

6 Scopus citations

Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects

Parchi, P., Giese, A., Capellari, S., Brown, P., Schulz-Schaeffer, W., Windl, O., Zerr, I., Budka, H., Kopp, N., Piccardo, P., Poser, S., Rojiani, A., Streichemberger, N., Julien, J., Vital, C., Ghetti, B., Gambetti, P. & Kretzschmar, H., Aug 23 1999, In : Annals of Neurology. 46, 2, p. 224-233 10 p.

Research output: Contribution to journalArticle

1028 Scopus citations

Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau

Bugiani, O., Murrell, J. R., Giaccone, G., Hasegawa, M., Ghigo, G., Tabaton, M., Morbin, M., Primavera, A., Carella, F., Solaro, C., Grisoli, M., Savoiardo, M., Spillantini, M. G., Tagliavini, F., Goedert, M. & Ghetti, B., Jun 1999, In : Journal of Neuropathology and Experimental Neurology. 58, 6, p. 667-677 11 p.

Research output: Contribution to journalArticle

Open Access
301 Scopus citations

Glial cell line-derived neurotrophic factor protects midbrain dopamine neurons from the lethal action of the weaver gene: A quantitative immunocytochemical study

Broome, J. D., Wills, K. V., Lapchak, P. A., Ghetti, B., Camp, L. L. & Bayer, S. A., Aug 5 1999, In : Developmental Brain Research. 116, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

15 Scopus citations